Yazarlar

• Arslan, Zikri(1)
• Ates, Mehmet(1)
• Aydin, Ayşe Nur(1)
• Bogatu, Corneliu(1)
• Daniels, James(1)
• Demir, Veysel(1)
• Farah, Ibrahim O.(1)
• Serdar, Osman(1)
• Çimen, Isıl Canan Çiçek(1)

• MakaleAçık Erişim2024Scopus SJRQ1/r/munzur/1924
  Determination of oxidative stress responses caused by aluminum oxide (γ-Al2O3 and α-Al2O3) nanoparticles in Gammarus pulex

  Serdar, Osman; Aydin, Ayşe Nur; Çimen, Isıl Canan Çiçek

  The rapid growth in the use of aluminum oxide nanoparticles (Al2O3 NPs) in various fields such as medicine, pharmacy, cosmetics industries and engineering, and the fact that these NPs and their wastes mix with the aquatic environment and damage the aquatic ecosystem, affect the organisms in the water, enter the food chain and reach humans is a major problem is cause for concern. The aim of this study is to investigate the oxidative stress caused by two separate forms of aluminum oxide, γ-Al2O3 and α-Al2O3, in Gammarus pulex, which is a good indicator species, with biochemical parameters. For this purpose, G. pulex was exposed to different concentrations (0, 10, 20, 40 ppm) of γ-Al2O3 and α-Al2O3 separately. The experiments were carried out for 24 and 96 h by creating 3 repeated experimental groups consisting of 4 groups. For biomarker analysis, superoxide dismutase (SOD), catalase (CAT) activities and glutathione (GSH) and thiobarbituric acid (TBARS) levels were performed using an ELISA kit. As a result of the in experimental study, it was observed that both nanoparticles affected oxidative stress and antioxidant parameters after 96 h compared to the control group. Increases in SOD activity were observed, γ-Al2O3 caused a decrease in CAT activity at 24 h, and α- Al2O3 caused increases in CAT activity at 96 h. Decreases in GSH levels and increases in TBARS levels have been observed.

  AtıfScopus14·OpenAlex14

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• MakaleÖn baskısı açık2015Scopus SJRQ2/r/munzur/4100
  Evaluation of Alpha and Gamma Aluminum Oxide Nanoparticle Accumulation, Toxicity, and Depuration in Artemia salina Larvae

  Ates, Mehmet; Demir, Veysel; Arslan, Zikri; Daniels, James; Farah, Ibrahim O.; Bogatu, Corneliu

  In this study, Artemia salina (crustacean filter feeders) larvae were used as a test model to investigate the toxicity of aluminum oxide nanoparticles (Al2O3 NPs) on marine microorganisms. The uptake, toxicity, and elimination of -Al2O3 (50 nm and 3.5 m) and -Al2O3 (5 nm and 0.4 m) NPs were studied. Twenty-four and ninety-six hour exposures of different concentrations of Al2O3 NPs to Artemia larvae were conducted in a seawater medium. When suspended in water, Al2O3 NPs aggregated substantially with the sizes ranging from 6.3 nm to >0.3 mu m for spherical NPs and from 250 to 756 nm for rod-shaped NPs. The phase contrast microscope images showed that NPs deposited inside the guts as aggregates. Inductively coupled plasma mass spectrometry analysis showed that large particles (3.5 m -Al2O3) were not taken up by Artemia, whereas fine NPs (0.4 m -Al2O3) and ultra-fine NPs (5 nm -Al2O3 and 50 nm -Al2O3) accumulated substantially. Differences in toxicity were detected as changing with NP size and morphology. The malondialdehyde levels indicated that smaller -Al2O3 (5 nm) NPs were more toxic than larger -Al2O3 (0.4 mu m) particulates in 96 h. The highest mortality was measured as 34% in 96 h for -Al2O3 NPs (5 nm) at 100 mg/L (LC50 > 100 mg/L). -Al2O3 NPs were more toxic than -Al2O3 NPs at all conditions. (c) 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 109-118, 2015.

  AtıfWoS65·OpenAlex84

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