Yazarlar
Yayınlar
- MakaleAçık Erişim2023Scopus SJRQ3Synthesis, Characterization, Antimicrobial and Time Killing Activities of New SulfaDerived Schiff Bases Coordinated with Cu(II)
İdil, Önder; Şahal, Hakan; Canpolat, Erdal; Özkan, Mustafa
Synthesis of three Schiff bases of 5-bromo-3-nitro salicylaldehyde containing different sulfonamide group antibiotic compounds and their Cu(II) complexes was carried out. Structures of all compounds were characterized with spectroscopic methods, including Fourier transform infrared, proton nuclear magnetic resonance, and elemental analysis. The in vitro antimicrobial activity of ligands and complexes against Gramnegative and Gram-positive bacteria and the yeast Candida albicans was evaluated. It was determined that the ligand and complexes showed outstanding antimicrobial activity against almost all of the microorganisms tested. It has been observed that the newly synthesized complexes have more antimicrobial effects than the corresponding ligands. It has been determined that the newly synthesized complexes have more antimicrobial effects than the others (E. coli, L. monocytogenes, and C. albicans), especially on Staphylococcus aureus and Pseudomonas aeruginosa.
AtıfScopus4WoS3OpenAlex2
İncele - MakaleAçık Erişim2023Scopus SJRQ4Cu(II) Complexes of New Sulfa Drug Schiff Base Ligands: Synthesis, Structural Characterization, Antimicrobial Activities, and Time-Killing Kinetics
Şahal, Hakan; İdil, Önder; Canpolat, Erdal; Özkan, Mustafa
Abstract: Synthesis of three different new sulfonamide compounds (L1–L3) and their Cu(II) complexes were carried out. Their structures were characterized by spectroscopic methods such as Fourier transform infrared, Proton nuclear magnetic resonance and elemental analysis. Cu(II) complexes were screened for Gram-positive, Gram-negative bacteria and against yeast using the microdilution method. In particular, CuL2 was found to have significant antimicrobial effects on Gram (–), Gram (+) and eukaryotic yeast. The results showed that CuL2 exhibited better antimicrobial activity than other complexes. Depending on the antimicrobial activity results, time killing experiments of CuL2, the most effective complex, were performed.
AtıfScopus3WoS2OpenAlex2İncele - MakaleYalnız künye2013Scopus SJRQ2Micelle nano-reactors as mediators of water-insoluble ligand complexation with Cu(II) ions in aqueous medium
Adigüzel, Ragip; Tascioglu, Senay
Complexation reactions between water-soluble and -insoluble reactants were shown to occur in aqueous media in the presence of normal or reverse surfactant micelles, in significantly higher yields at lower temperatures compared to those achieved in neat organic solvents. The highest yield enhancement in the complexation of novel water-insoluble bis(2-amino-1,3,4-thiadiazolyl)methane and 1,4-bis(2-amino-1,3,4-thiadiazolyl)benzene ligands with Cu(II) ions was achieved in the sodium bis(2-ethylhexyl)sulfosuccinate (AOT)-heptane-water reverse micellar system at the hydration ratio of 15. The results revealed that AOT normal micelles cause a change in the reaction mechanism together with the enhancement of the complex formation. The observed micellar effects were rationalized on basis of the properties of bulk solvents, surfactants and ligands, considering the solvation and hydration ratios of reverse micelles. The results have proved the dependence of complex yield on the amount and accordingly also on the properties of water in the micellar core, indicating that the yield can be maximized by the optimization of the hydration ratio.
AtıfWoS4OpenAlex5İncele