Sürdürülebilir Kalkınma Amaçları

• 2

Yazarlar

• Cakilcioglu, Ugur(2)
• Zengin, Gokhan(2)
• Ak, Gunes(1)
• Bahsi, Muammer(1)
• Balos, Maruf(1)
• Custódio, Luísa(1)
• Darendelioglu, Ekrem(1)
• Fernández-Ochoa, Álvaro(1)
• Ferrante, Claudio(1)
• Jiménez, Francisco-Javier Leyva(1)
• Llorent-Martínez, Eulogio J.(1)
• Nilofar(1)
• Orlando, Giustino(1)
• Pereira, Catarina G.(1)
• Polat, Rıdvan(1)
• Rodrigues, Maria João(1)
• Sinan, Kouadio Ibrahime(1)
• Soomro, Sanam Iram(1)
• Uba, Abdullahi Ibrahim(1)
• de la Luz Cádiz-Gurrea, María(1)

• MakaleAçık Erişim2025Scopus SJRQ1/r/munzur/2022
  Incorporating the HPLC-ESI-Q-TOF-MS profiles with the biochemical properties of eight Salvia species

  Llorent-Martínez, Eulogio J.; Nilofar; Sinan, Kouadio Ibrahime; Darendelioglu, Ekrem; Bahsi, Muammer; Polat, Rıdvan; Cakilcioglu, Ugur; Orlando, Giustino; Ferrante, Claudio; Zengin, Gokhan

  Salvia, a widely recognized genus globally esteemed for its traditional and medicinal applications, prompted our investigation into the methanol and water extracts of eight Salvia species native to Turkey. These species included S. aucheri, S. candidissima, S. divaricata, S. virgata, S. multicaulis, S. palestina, S. trichoclada, and S. cerino-pruinosa. Our study aimed to assess their biological properties and chemical composition. Utilizing HPLC-ESI-Q-TOF-MS, we identified chemical constituents in the extracts, while antioxidant (radical quenching, reducing power, and metal chelating) and enzyme inhibitory (amylase, glucosidase, tyrosinase, and cholinesterase) activities were evaluated for biological activities. One hundred thirty-one compounds were characterized in the tested extracts. Although many compounds belonging to different chemical families were identified, the main compounds in all the extracts were rosmarinic and sagerinic acids, along with several salvianolic acid isomers. Notably, the methanol extracts displayed superior antioxidant properties overall, with S. cerino-pruinosa exhibiting the highest activity among them, except for metal chelating. Similar to the antioxidant test results, the methanol extracts were more active than the water extracts in the enzyme inhibition tests. Multivariate analysis further highlighted the distinctiveness of the water extract of S. cerino-pruinosa. In conclusion, our findings underscore the biopharmaceutical potential of the tested Salvia species, suggesting their significance as sources of bioactive agents for health-promoting applications.

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  AtıfScopus17·OpenAlex15

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• MakaleAçık Erişim2024Scopus SJRQ2/r/munzur/2086
  Cytotoxic, antioxidant, and enzyme inhibitory activities of Centaurea stapfiana extracts and their HPLC-ESI-QTOF-MS profiles: Insights into an unexplored Centaurea species

  Zengin, Gokhan; Fernández-Ochoa, Álvaro; de la Luz Cádiz-Gurrea, María; Jiménez, Francisco-Javier Leyva; Uba, Abdullahi Ibrahim; Ak, Gunes; Soomro, Sanam Iram; Balos, Maruf; Cakilcioglu, Ugur; Rodrigues, Maria João

  The members of the genus Centaurea have a great interest in pharmaceutical and nutraceutical fields due to their biological potential. Based on this information, we aimed to evaluate the biological properties (antioxidant, enzyme inhibition and cytotoxicity) and chemical profile of the extract of Centaurea stapfiana, an unstudied species. The highest total phenolic content was found in the ethanol/water extract with 32.17 mg GAE/g. A total of 102 of them were identified by HPLC-ESI-QTOF-MS analysis. These compounds were mainly hydroxybenzoic acid and hydroxycinnamic acid as well as flavonoids. In the antioxidant tests, the ethanol/water extract had the best free radical scavenging and reducing ability. However, in the enzyme inhibition test, the ethanol extract was the most active. The extracts were also tested on two tumour cell lines (RAW 264.7 and HepG2) and one non-tumour cell line (S17). The ethanol extract showed the promising effect on HepG2 (cell viability: 28.6 % at 50 g/ml). Furthermore, we examined the interactions between the compounds and enzymatic and cellular targets. A good interaction was found between quercetin-3-xylosyl-(1- > 6)-glucoside and iNOS. In summary, our results suggest that C. stapfiana can be considered as a versatile raw material for the development of health-promoting applications in the pharmaceutical and cosmeceutical fields.

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  AtıfScopus13·OpenAlex14

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