Yazarlar
- Buldurun, Kenan(3)
- Turan, Nevin(3)
- Adiguzel, Ragip(2)
- Adigüzel, Ragip(2)
- Körkoca, Hanifi(2)
- Çolak, Naki(2)
- Adiguzel, R.(1)
- Aras, Abdülmelik(1)
- Bursal, Ercan(1)
- Colak, Naki(1)
- Donmez, Melike(1)
- Ergin, Z.(1)
- Gündüz, Bayram(1)
- Oğuz, Ercan(1)
- Sekerci, M.(1)
- Sekerci, Memet(1)
- Turkan, Fikret(1)
- Türkan, Fikret(1)
- Yildiko, Umit(1)
Yayınlar
- MakaleAçık Erişim2025Scopus SJRQ2Synthesis and characterization of novel bis(thiosemicarbazone) complexes and investigation of their acetylcholinesterase and glutathione S-transferase activities with in silico and in vitro studies
Donmez, Melike; Sekerci, Memet; Adiguzel, Ragip; Oğuz, Ercan; Türkan, Fikret; Yildiko, Umit; Colak, Naki
In this study, firstly, bis(thiosemicarbazone) ligand [L: 2,2′-(2-(2-(4-methoxyphenyl)hydrazineylidene)cyclohexane-1,3-diylidene)bis(hydrazine-1-carbothioamide)] was synthesized by the condensation reaction of thiosemicarbazide and ketone compound (2-(2-(4-methoxyphenyl)hydrazone)cyclohexane-1,3-dione). The metal complexes were synthesized by the reaction of obtained ligand (L) with CuCl2·2H2O, NiCl2·6H2O, CoCl2·6H2O, and MnCl2·4H2O salts. The structures of synthesized ligand and their complexes were characterized using elemental analysis, IR, UV–Vis, 1H-NMR spectra, 13C-NMR spectra, magnetic susceptibility, mass spectra (LC–MS), thermogravimetry analysis-differential thermal analysis (TGA-DTA), and differential scanning calorimetry techniques. According to the results of the analysis, square plane geometry was suggested for Cu and Co complexes. However, the structures of Ni and Mn complexes were in agreement with octahedral geometry. Molecular docking analysis and pharmacological potential of the compound were evaluated to determine the inhibitory potential against acetylcholinesterase (AChE) and Glutathione-S-transferases (GST) enzymes. The compound exhibited strong binding/docking indices of − 5.708 and − 5.928 kcal/mol for the respective receptors. In addition, L–Ni(II) complex was found to be the most effective inhibitor for AChE enzyme with a Ki value of 0.519. However, with a Ki value of 1.119, L–Cu(II) complex was also found to be an effective inhibitor for the GST enzyme.
AtıfScopus21OpenAlex19
İncele - MakaleAçık Erişim2021Scopus SJRQ2Investigation of spectroscopic, thermal, and biological properties of FeII, CoII, ZnII, and RuII complexes derived from azo dye ligand
Turan, Nevin; Buldurun, Kenan; Adiguzel, Ragip; Aras, Abdülmelik; Turkan, Fikret; Bursal, Ercan
In this study, the novel azo dye FeII, CoII, ZnII, and RuII complexes with an azo dye ligand (L: (E)-4-((4-methoxyphenyl)diazenyl)-3-methyl-1H-pyrazol-5-amine) were synthesized. The structures of the complexes were characterized by FT-IR, elemental analysis, UV-Vis, mass spectra (FeII and CoII), NMR spectra (only diamagnetic ZnII and RuII), thermogravimetric and differential thermal analysis (TGA-DTA). All of the newly synthesized compounds were tested for their biochemical properties, including enzyme inhibitory and antioxidant activities. According to the in vitro ABTS, DPPH, CUPRAC, and FRAP antioxidant methods, the ligand and its metal complexes showed close antioxidant activities to the standards (BHA, BHT, ascorbic acid, and α-tocopherol). Enzyme inhibitions of the metal complexes were investigated against glutathione S-transferase (GST), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. The best inhibition values (Ki) were observed for Ru(II) complex against GST (14.36 ± 2.16 µM), AChE (16.86 ± 2.74 µM), and BChE (14.12 ± 2.04 µM).
AtıfScopus45WoS45OpenAlex45İncele - MakaleAçık Erişim2015Scopus SJRQ2Synthesis, Structural Characterization and Biological Activity of Novel Cyclohexane-1,3-dione Ligands and Their Metal Complexes
Turan, Nevin; Körkoca, Hanifi; Adigüzel, Ragip; Çolak, Naki; Buldurun, Kenan
Some new Zn(II) and Cu(II) complexes [Cu(L-1)(OAc)(2)].H2O, [Cu(L-1)(NO3)H2O].NO3.3.5H(2)O, [Zn(L-1)(NO3)(2)].4.5H(2)O, [Zn(L-1)(OAc)(2)(H2O)(2)].3H(2)O, [Cu-2(L-2)(OAc)(4)].2H(2)O.2DMF, [Cu(L-2)(2)].2NO(3).1.5DMF.H2O, [Zn(L-2)(2)(NO3)(2)].DMF and [Zn-2(L-2)(OAc)(4)(H2O)(4)].5H(2)O; L-1 = 2-[2-(2-methoxyphenyl)hydrazono]cyclohexane-1,3-dione and L-2 = 2-[2-(3-nitrophenyl)hydrazono]cyclohexane-1,3-dione were synthesized and characterized by IR, H-1-NMR,C-13-NMR and ultraviolet (UV-Vis.) spectroscopy, elemental analysis, magnetic susceptibility, mass spectrometry and thermogravimetry-differential thermal analysis (TGA-DTA). The synthesized ligands and their complexes were tested for antibacterial activity against Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, and Salmonella typhimurium CCM 583. Some of complexes showed medium-level antibacterial activity against the test bacteria compared with ampicillin.
AtıfWoS20OpenAlex18İncele - MakaleYalnız künye2014Scopus SJRQ3Study of Structure and Spectral Characteristics of the Zinc(II) and Copper(II) Complexes With 5,5-Dimethyl-2-(2-(3-nitrophenyl) hydrazono)cyclohexane-1,3-dione and Their Effects on Optical Properties and the Developing of the Energy Band Gap and Investigation of Antibacterial Activity
Turan, Nevin; Gündüz, Bayram; Körkoca, Hanifi; Adigüzel, Ragip; Çolak, Naki; Buldurun, Kenan
A new chelating ligand, 5,5-dimethyl-2-(2-(3-nitrophenyl)hydrazono)cyclohexane-1,3-dione (L), and four transition metal complexes were synthesized. The ligand and its complexes were characterized by IR, H-1 and C-13-NMR spectra, elemental analyses, magnetic susceptibility, mass spectra, UV-Vis. and thermogravimetry-differential thermal analysis (TGA-DTA). The metal complexes showed different geometric structures. Antibacterial tests of the ligand and complexes were also done. The Zn(II) complexes showed antibacterial activity against Staphylococcus aureus ATCC-25923 at middle level. The optical properties of the ligand and its complexes were extensively investigated by optical measurements. The average transmittance value of the ligand was the highest value, while the average transmittance value of the [CuL2(NO3)(2)]center dot 6H(2)O complex was the lowest value. The optical band gap of the ligand, [(Zn)(2)L(OH)(4)]center dot 2DMF, [ZnL(NO3)(2)(H2O)(2)]center dot 5H(2)O, [CuL2(OAc)]center dot OAc center dot 3.5H(2)O and [CuL2(NO3)(2)]center dot 6H(2)O complexes were calculated and 3.121 eV, 2.180 eV, 1.551 eV, 2.489 eV and 1.556 eV values were found, respectively. The complexes decreased the optical band gap of the ligand. The optical band gap value of the [ZnL(NO3)(2)(H2O)(2)]center dot 5H(2)O complex is the lowest value. The optical band gap value of the ligand is the highest value. The complexes decrease the angle of incidence of the ligand, while complexes increase the angle of refraction of the ligand. The electric susceptibility of the ligand decreases with its complexes.
AtıfWoS28İncele - MakaleYalnız künye2010Scopus SJRQ3Synthesis and Structural Characterization of Ni(II), Cu(II), Zn(II) and Cd(II) Complexes of Bis(2-amino-1,3,4-thiadiazole)
Adiguzel, R.; Ergin, Z.; Sekerci, M.
In this study, the ligand bis(2-amino-1,3.4-thiadiazole) (L) has been synthesized by the reactions of oxalic acid with thiosemicarbazide The ligand and Ni(II), Cu(II), Zn(II), Cd(II) complexes have been synthesized and its structures of these compounds have been deter-mined by elemental analysis. spectrometric and TGA/DTA, magnetic susceptibility and molar conductivity measurements. Coordination numbers of monomeric Ni(I I) and Cd(II) complexes are six and four, respectively. The coordination numbers of dimeric Cu(II) and Zn(II) complexes are live and four. From the elemental analysis and mass spectral data, the complexes were pi posed to have the formula[Ni(L)(2)(SO4)H2O]0 5DMF 2H(2)O center dot[Cu(L)(SO4)H2O](2)center dot DMF 2H(2)O, [Zn(L)(NO3)](2) 2NO(3)center dot 2DMF center dot H2O and [Cd(L)(2)] 2NO(3)center dot 1.5DMF center dot H2O. Ni (II) and Cu(II) complexes are paramagnetic and non-electrolytes. The molar conductance data revealed that zinc(II) and cadmium(II) complexes are 1 2 electrolytes.
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