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- MakaleYayıncıda açık erişim2025Scopus SJRQ4The effect of Dimethoate on oxidative stress and antioxidant responses of Pontastacus leptodactylus; [El efecto del dimetoato sobre el estrés oxidativo y las respuestas antioxidantes de Pontastacus leptodactylus]
Aydın, Ayşe Nur; Bulut, Hilal; Serdar, Osman
Dimethoate (DMT) pesticide is one of the chemicals used to protect some agricultural areas from harmful organisms. DMT residues released directly or indirectly to the environment cause serious problems in nature. DMT residues mixed with the aquatic environment adversely affect aquatic organisms and this effect is carried to humans through the food chain. In this study, oxidative stress responses induced by DMT pesticide in Pontastacus leptodactylus were investigated. For this purpose, oxidative stress and antioxidant parameters Thiobarbituric acid reactive substances (TBARS), Glutathione (GSH), Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) caused by dimethoate (DMT) pesticide in P. leptodactylus at 17.5, 35, and 70 mg·L-1 concentrations at 24 and 96 hours were investigated. Results were determined using ELISA kits. No significant difference was observed in GSH levels and SOD activities compared to control. Statistically significant differences were observed between decreases in CAT and GPx activities and increases in TBARS levels. SPSS 24.0 package program one–way ANOVA (Duncan 0.05) was used in the evaluation of biochemical analyzes. As a result, it was determined that DMT caused oxidative stress formation in P. leptodactylus and caused changes in enzyme activities.
AtıfScopus1WoS1
İncele - MakaleAçık Erişim2025Scopus SJRQ4Protective Effect of Sumac and Terebinth Extracts Against the Negative Effects of Breast Cancer on Cardiac Tissues of in Rats; [Efecto protector de los extractos de zumaque y terebinto contra los efectos negativos del cáncer de mama en los tejidos cardíacos de ratas]
Erişir, Figen Erdem; Aydın, Sevinç; Tuzcu, Zeynep; Yılmaz, Ökkeş
Due to the toxic side effects of chemotherapeutic drugs used in breast cancer, interest in medicinal plants has increased in order to develop alternative cancer drugs. The experimental model of this study was created to observe the remedial impacts of the Terebinth (Pistacia terebinthus L.) and the Sumac (Rhus coriaria L.) plants against the negative effects of 7,12-Dimethylbenz[a]anthracene induced breast cancer on cardiac tissues in rats. For this purpose, the levels of malondialdehyde were analyzed the indicator of the oxidative stress breast cancer will cause on cardiac tissues, the catalase, glutathione transferase and superoxide dismutase enzymes, glutathione, which holds and important place among antioxidant impacts and proteins. At the end of the study, it was determined that there was an increase in malondialdehyde levels, a decrease in glutathione and protein amounts, and a decrease in antioxidant enzyme levels in rats treated with cancer-induced 7,12-Dimethylbenz[a]anthracene.