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Koleksiyondaki öğeler
- MakaleYalnız künye2012Scopus SJRQ3HATCHING PERFORMANCES AND YOLK SAC ABSORPTIONS OF CASPIAN BROWN TROUT (SALMO TRUTTA CASPIUS T., 1954)
Kocabas, M.; Basçinar, N.; Sahin, S. A.; Kutluyer, F.
Salmo trutta caspius T., 1954 is a native to Caspian Sea and is an important fish species due to its aquaculture potential, economic value and high marketability. The aims of this study were to determine hatching rate, body and yolk weight at hatching, the growth rate during the yolk absorption and yolk conversion efficiency of S. I. caspius larvae. Studies were further extended to determine the relationships between length, total wet weight, dry yolk body weights of alevins and degree-days. Results revealed that the mean wet weight was 16.78 +/- 2.17 mg (n = 10) at hatching and reached 52.62 +/- 3.55 mg just before the swim-up stage. The mean dry weights of the body and yolk sac were 2.36 +/- 0.28 mg and 10.67 +/- 0.67 mg at hatching and 7.21 +/- 0.71 mg and 2.57 +/- 0.62 mg at swim-up stages, respectively. The mean body dry matter and water content of the larvae were 33.10% and 66.90% at hatching and 15.46% and 84.54% of the total biomass at swim-up stages, respectively. Our results indicated that dry yolk, total larval weights and dry matter of the larvae decreased, while body weight and water content increased with degree-days. The growth of larva, yolk sac absorption and yolk conversion efficiency were calculated as 0.18 mg/day, 0.23 mg/day and 0.60, respectively. The data collected during these studies contribute to the management practices of the stocks of this species.
AtıfWoS2
İncele - MakaleYalnız künye2016Scopus SJRQ3ANTIMONY INDUCED GLUTATHIONE EFFLUX FROM HUMAN ERYTHROCTES
Sahilli, Yeliz Cakir; Akgun, Mehmet Hanifi; Yildiz, Deniz
Antimony is a trace element which has wide variety of industrial application. Antimony has recently been considered as an environmental pollutant. Among the inorganic forms, SbIII is the more toxic form. SbIII is ten times more toxic compared to the SbV. Consuming plants that are grown in antimony contaminated soil is one of the way by which humans are exposed to antimony. AsIII and SbIII forms strong bonds with free-SH groups. When SbIII or SbV interacts with proteins that contain free-SH groups, protein inactivation usually results in. Antimony may also result in free radical generation and induction of oxidative stress. Even though antimony has some applications in health as a drug, its biological effects have not been investigated in detail. In the present study we investigated the effects of SbIII on glutathione efflux in human erythrocytes. The effects of N-acetyl-L-cysteine on antimony induced glutathione oxidation and glutathione efflux were also investigated. Extracellular glutathione concentration significantly increased and reached to 0.033 +/- 0.0034 micromole/ml erythrocyte with 1 mM of potassium antimony tartrate in four hours. The control value of extracellular glutathione was 0.020 +/- 0.0035 micromole/ml erythrocyte. Our results show that SbIII treatment of erythrocyte results in glutathione efflux.
AtıfWoS2İncele - MakaleAçık Erişim2017Scopus SJRQ1Evaluation of physical and mechanical characteristics of siderite concrete to be used as heavy-weight concrete
Esen, Yuksel; Dogan, Zulfu Murat
The objective of this study is to investigate the usability of siderite aggregates mentioned above as a heavy-weight aggregate in the heavy-weight concrete production and their effects on physical properties of the heavy-weight concrete mixture. For this purpose, normal-weight aggregate content was decreased at the rate of 20%, 40%, 60%, 80% and 100% by volume of the concrete mixture prepared and mixtures were prepared by its substitution with siderite aggregate at the same rates. Based on the increase in siderite aggregate in the concrete mixture, a considerable increase in unit weight, compressive strength and tensile strength of concrete was obtained. Plate-shaped concrete specimens obtained from combined normal-weight and heavy-weight aggregates were exposed to radiation with different X-ray source (118 keV, 164 keV) and Co-60 (1250 keV) beam source at cekmece Nuclear Facility. It is clearly seen that the concrete mixture containing siderite aggregate improved 70% radiation absorption characteristics compared to that of the concrete mixture without siderite aggregate. (C) 2017 Elsevier Ltd. All rights reserved.
AtıfWoS53OpenAlex51İncele - MakaleYalnız künye2021Factors Affecting Parents' Share on Social Media about Their Children
Turgut, Yigit Emrah; Kopuz, Tuba; Aslan, Alper; Toksoy, Seyhan Eryilmaz
In this study, it was aimed to determine the factors affecting parents' share on social media about their children. This is a qualitative study which was conducted with the participation of 88 parents. Data were collected through an online questionnaire consisting of open-ended questions. It was revealed that most of parents participating in the study posted about their children on social media. It was determined that parents mostly pay attention to the children's appearance and privacy while sharing posts regarding their children on social media. It has been observed that among the factors affecting sharing, the factor of staying in contact with the social environment of the parents stands out. Besides, some parents' desire to make special days permanent and the fact that their shares make them feel happy were other factors which draw attention. It was concluded that the parents did not have sufficient knowledge about the legal processes that may arise from their social media posts.
AtıfWoS4TR Dizin6
İncele - MakaleAçık Erişim2026A Consensus-Edge Initializer for Multi-start 2-opt on the Symmetric Euclidean Travelling Salesman Problem
Saygili, Ahmet Caglar; Kazan, Halim
We study a one-shot consensus-based initializer for multi-start 2-opt on symmetric Euclidean Travelling Salesman Problem (TSP) instances. Given the M local minima from best-of-M 2-opt, we count undirected edge frequencies, greedily assemble a tour from the most frequent edges with a length-biased tie-break, and run a single additional 2-opt descent from this seed. The local search operator is unchanged; the consensus stage reuses existingtours and adds only a small overhead beyond the M descents, and we characterise this overhead analytically while focusing evaluation on tour length improvements. On synthetic Euclidean instances from three generators, we evaluate performance over a grid of problem sizes n and restart budgets M. The consensus + 2-opt pipeline improves best-of-M 2-opt by roughly 3-6% in median tour length with high win rates for n >= 500 and moderate M, while for small n and large M the baseline saturates and gains shrink to zero or slightly negative values. Thus, even a single aggregation step over 2-opt local minima yields a simple, reproducible seed that is beneficial in the practically relevant regime of moderate budgets and larger instances and approximately neutral elsewhere.
- MakaleYalnız künye2014Scopus SJRQ2EFFECT OF COPPER OXIDE NANOPARTICLES TO SHEEPSHEAD MINNOW (CYPRINODON VARIEGATUS) AT DIFFERENT SALINITIES
Ates, M.; Dugo, M. A.; Demir, V.; Arslan, Z.; Tchounwou, P. B.
Nanotechnologies research has become a significant priority worldwide. Many engineered nano-sized materials have been increasingly used in consumer products. But the adverse effects of these nanoparticles on the environment and organisms have recently drawn much attention. The present study investigated the effects of different concentrations of copper oxide nanoparticles (CuO NPs) on the sheepshead minnow (Cyprinodon variegatus) at different salinity regimes, since it is able to withstand a wide range of salinities. The results indicated that CuO NPs could cause behavioral changes in the fish, such as increased mucus secretion, less general activity and loss of equilibrium. No mortality was observed at the presence of CuO NPs during the experiments. But higher oxidative stress was determined at half strength seawater than seawater exposure medium, which can be associated with the decreasing toxicity of CuO NPs as salinity increases. In addition, Cu contents in the tissues of the fish were significantly higher (p<0.05) in the low salinity. The order of Cu accumulation in the fish's organs was intestine > gills > liver.
AtıfWoS25İncele - MakaleAçık Erişim2026Scopus SJRQ3Ten-Year Trends in Kidney Transplantation by Donor Type, Age, Dialysis, and Sex/Gender Inequality in Turkiye
Ordin, Yaprak Sarigol; Kankaya, Eda Ayten; Celik, Buket
Introduction: Gender disparity remains a global issue in access to renal replacement therapy and kidney transplantation among patients with end-stage kidney disease. Aim: This study examined trends in donor type, recipient age, and dialysis modality in kidney transplantation in T & uuml;rkiye from 2013 to 2022. A secondary aim was to explore gender disparities in kidney transplantation and treatment modalities for end-stage kidney disease using registry data. Methods: This descriptive and cross-sectional study analyzed the distribution and trends of kidney transplants in T & uuml;rkiye between 2013 and 2022. The data were obtained from the publicly accessible Registry of Nephrology, Dialysis, and Transplantation reports in Turkiye. Per million population increase/decrease rate, chi(2) linear trend, and chi(2) R by C were used. Results: Overtime, transplants from living donors increased, while deceased donor transplants decreased. The highest rates of living donor transplants were in 2022, 2021, and 2019. Transplants in high-risk age groups increased significantly. There were differences in donor type among patients receiving hemodialysis, peritoneal dialysis, or preemptive transplantation (p < .001). Preemptive transplants showed the most significant increase, especially from living donors in 2022. Between 2013 and 2022, kidney transplantation increased by 24.67% in men and 19.94% in women. Female transplant rates were lowest in 2016, 2020, and 2021, indicating a persistent gender gap. There was no significant gender difference in the incidence of hemodialysis or peritoneal dialysis. Conclusion: Living donor transplants, especially preemptive ones, increased markedly over the past decade. Gender disparities persist, and efforts should focus on improving access for women and promoting deceased donor programs to ensure equity.
AtıfWoS1OpenAlex1
İncele - MakaleYalnız künye2010Scopus SJRQ3The effects of commercial diets supplemented with mannanoligosaccharide (MOS) and vitamin B12 on the growth and body composition of the shabbout fries (Tor grypus H. 1843)
Atar, Hasan Huseyin; Ates, Mehmet
Four hundred shabbout fries (Tor grypus L. 1758), with average initial weight of 0.95+/-0.02 g and total average length of 4.10+/-0.05 cm, were fed for a period of 90 days commercial feed with addition of mannanoligosaccharide (MOS) and vitamin B-12. The shabbouts were divided into four different groups and fed by different feeds (Control, Group A with MOS, Group B with vitamin B-12, Group C with the combination of MOS + vitamin B-12). The effects of feeding through MOS and vitamin B-12 in different proportions on growth in view of live weight and total length, survival rate, feed conversion, condition factor and protein efficacy were studied. The best growth in view of live weight of 4.51+/-0.16 g and length of 7.71+/-0.08 cm was maintained through vitamin B-12 in Group B. As a consequence, the growth parameters of the shabbout fries fed through commercial feeds with the addition of MOS and vitamin B-12 in different doses under empirical conditions showed affirmative effects on the survival rate, feed assessment, condition factor and protein efficacy.
- MakaleAçık Erişim2010Scopus SJRQ2Flame Atomic Absorption Spectrometric Determination of Pb, Cd, and Cu in Pinus nigra L. and Eriobotrya japonica Leaves Used as Biomonitors in Environmental Pollution
Kaya, Gokce; Ozcan, Cemile; Yaman, Mehmet
The assessment of trace metal pollution in Gaziantep city-Turkey has been studied using plant leaves of Pinus nigra L. and Eriobotrya japonica as biomonitor. The concentrations up to 3,056 mg Pb kg(-1) in the needles of Pinus nigra L., and 367 ng Cd g(-1) in the leaves of Eriobotrya japonica were determined. The observed Cu concentrations were in range of 1.6-7.1 mg kg(-1). The Pb, Cd, and Cu levels in soils were determined to be in the range of 17-602, 0.142-0.656, and 12-38 mg kg(-1), respectively. It was concluded that Pinus nigra L. can be considered as both biomonitor of atmospheric Pb pollution and hyperaccumulator plant.
AtıfWoS41OpenAlex37İncele - MakaleYalnız künye2017Scopus SJRQ3SPATIAL AND TEMPORAL DISTRIBUTION OF PHYTOPLANKTON IN KARKAMIS DAM LAKE (SANLIURFA/TURKEY)
Sonmez, Feray; Kutlu, Banu; Sesli, Ahmet
The environmental factors that affect the seasonal change of the phytoplankton community and composition in Karkamis Dam Lake were investigated on samples taken from five stations between January 2015 and December 2015. It was found that the phytoplankton of Karkamis Dam Lake consisted of 85 taxa belonging to Bacillariophyta (56 taxa), Chlorophyta (15 taxa), Chrysophyta (1 taxon), Cyanophyta (10 taxa), Dinophyta (2 taxa) and Euglenophyta (1 taxon). Members of Bacillariophyta and Chrysophyta increased well during spring, summer and also at the end of fall whilst Chlorophyta grew well only in summer and fall. Cyanophyta became dominant at the end of spring and in summer. However Dinophyta was remarkably conspicuous in winter as well as in spring and fall in terms of prevalence. Excessive reproduction of Cyanobacteria, which is a characteristic aspect of mesotrophic lakes, was observed in Karkamis Dam Lake in both May and July. Results of physical and chemical measurements and analysis indicated that the lake was mesotrophic based on PCA and Carlson trophic state index. Phytoplankton composition was found to be affected by environmental factors such as temperature, pH, dissolved oxygen, phosphate and nitrate through the year. Using these data, a strong model was developed for sustainable management in Karkamis Dam Lake.
AtıfWoS3İncele - MakaleYayıncıda açık erişim2018Scopus SJRQ1Investigation of usability of limonite aggregate in heavy-weight concrete production
Esen, Yuksel; Dogan, Zulfu Murat
Limonite (Fe2O3.xH(2)O) is a soft or brown, hard iron mineral, usually in yellow colour. It is also used as a pigment since it contains iron ore. It is believed that it can also be used in the production of heavy concrete due to its 60% iron ore content. In this paper, an experimental study was carried out on radiation shielding properties and certain physical and mechanical properties of normal and limonite reinforced concrete. For this purpose, with the normal concretes prepared according to standards, amounts of aggregates were reduced at the rates of 20%, 40%, 60%, 80% and 100% by volume respectively, and heavy concrete mixes were prepared that were obtained by adding limonite at the same rates in their place. With limonite reinforcement, compressive and flexural strength of the concrete produced decreased, water absorption amount increased and their radiation permeability significantly decreased.
AtıfWoS54OpenAlex56İncele - MakaleYalnız künye2010Scopus SJRQ3Synthesis and Structural Characterization of Ni(II), Cu(II), Zn(II) and Cd(II) Complexes of Bis(2-amino-1,3,4-thiadiazole)
Adiguzel, R.; Ergin, Z.; Sekerci, M.
In this study, the ligand bis(2-amino-1,3.4-thiadiazole) (L) has been synthesized by the reactions of oxalic acid with thiosemicarbazide The ligand and Ni(II), Cu(II), Zn(II), Cd(II) complexes have been synthesized and its structures of these compounds have been deter-mined by elemental analysis. spectrometric and TGA/DTA, magnetic susceptibility and molar conductivity measurements. Coordination numbers of monomeric Ni(I I) and Cd(II) complexes are six and four, respectively. The coordination numbers of dimeric Cu(II) and Zn(II) complexes are live and four. From the elemental analysis and mass spectral data, the complexes were pi posed to have the formula[Ni(L)(2)(SO4)H2O]0 5DMF 2H(2)O center dot[Cu(L)(SO4)H2O](2)center dot DMF 2H(2)O, [Zn(L)(NO3)](2) 2NO(3)center dot 2DMF center dot H2O and [Cd(L)(2)] 2NO(3)center dot 1.5DMF center dot H2O. Ni (II) and Cu(II) complexes are paramagnetic and non-electrolytes. The molar conductance data revealed that zinc(II) and cadmium(II) complexes are 1 2 electrolytes.
AtıfWoS5İncele - MakaleYayıncıda açık erişim2014Scopus SJRQ3Temporal Changes in Concentrations of Some Trace Elements in Muscle Tissue of Crayfish, Astacus leptodactylus (Eschscholtz, 1823), from Keban Dam Lake
Aksu, Onder; Adiguzel, Ragip; Demir, Veysel; Yildirim, Numan; Danabas, Durali; Seker, Sebahat; Can, Safak Seyhaneyildiz; Ates, Mustafa
Crayfish (Astacus leptodactylus Eschscholtz, 1823) is the native crayfish species in Turkey. It was exported regularly to Western Europe. In this study, bioaccumulation and temporal trends of some trace elements (arsenic: As, cadmium: Cd, copper: Cu, mercury: Hg, lead: Pb, and zinc: Zn) in edible abdomenmuscle of crayfish from Keban Dam Lake (Elazig, Turkey) were investigated for the 2006-2012 period. Sequence of metal concentration levels was Zn > Cu > Hg > Pb > Cd > As in muscle tissues. The highest concentration of Zn (21.69mg kg(-1)) was detected in 2006, while the lowest (4.35mg kg(-1)) in 2009. In general, it was found that the concentrations of trace elements investigated were lower than the maximum permissible limits of the food regulations of the Ministry of Food, Agriculture, and Livestock (MFAL), the Turkish Food Codex and Commission Regulation (EC). If the crayfish selected for the study are recognized as bioindicators of environmental pollution, then it is possible to conclude that the changes in studied trace elements concentrations in the Keban Dam Lake are being steady.
AtıfWoS5OpenAlex8İncele - MakaleYalnız künye2018Scopus SJRQ4Effect of Water Quality on Monthly Density Variation of the Endangered Southern Medicinal Leech Hirudo verbana Carena, 1820 (Hirudinea: Arhynchobdellida: Hirudinidae)
Saglam, Naim; Özbay, Ozkan; Demir, Timur; Balci, Mustafa; Pala, Aysegul; Kiliç, Ali
The species of the genus Hirudo are threatened but still used worldwide in human treatment. We studied the density changes of southern medicinal leech Hirudo verbana and some water quality parameters monthly during a year in the Akpinar Marsh, Eastern Anatolia, Turkey. Samples of H. verbana were collected using a modified unit square design and unit time collecting method as an indicator for population density. Some water parameters such as water temperature, dissolved oxygen, pH, some cationic elements (lithium, sodium, ammonium, potassium, magnesium, calcium) and anionic elements (fluoride, chloride, sulphate, nitrate, phosphate, bromide) were determined. These parameters were analysed to detect their impact on population density of this medicinal leech. The populations of H. verbena were most dense in May-June; the species was found in smallest numbers in November and hibernating in December-March. A significant correlation (p<0.05) between the number of medicinal leeches in the unit area and monthly water temperature, amount of ammonium and fluoride was determined using the Pearson correlation coefficient. In the Akpinar Marsh, the largest adult medicinal leeches (>5 g) in the fourth size group formed 12.50-27.50% of the population and the smallest (<1.0 g) in the first size group formed 7.50-38.24%.
AtıfWoS3İncele - MakaleYalnız künye2010Scopus SJRQ4Is it Possible to Transform Hatchery-Reared Abnormal Juveniles of Sea Bass (Dicentrarchus labrax L. 1758) into Normal Individuals?
Kayim, M.; Can, E.; Güner, Y.
Lordosis, which is one of the skeletal deformations, was frequently encountered in the culture of sea bass (Dicentrarchus labrax L. 1758) and it affects the biological performance and marketing image of the fish negatively. Thus it causes big economic losses. In larger natural environments, this abnormality in wild-caught individual is rare, whereas the case is the other way round in hatchery-reared sea bass. This problem can be caused by swim bladder malformations, environmental conditions, bacterial factors, water flow rate and swimming activity. However, many researchers reported that all of these factors cause these malformations in different regions of the skeletal system, commonly known as V-shaped curvatures. But in this study, it is not aimed to investigate the possible causes of the observed abnormalities. We focused on whether the abnormal individuals can be transformed into individuals with normal skeletal systems. In this study, a total number of 5636 juvenile individuals (0.09-1.93 g of live weight) were used. Lordosis rates were identified between the days 54 and 110 by randomly taking at least 30 samples from every group on a weekly basis, at triplicate. In this study, 100% of the individuals with this type of deformation were successfully transformed into individuals with the normal skeletal system in a large volume and rectangular ponds with semi-intensive rearing method.
AtıfWoS9İncele - MakaleYalnız künye2011Scopus SJRQ3Physico-chemical and Microbiological Water Quality Assessment of Perisuyu River, Tunceli, Turkey
Kaplan, O.; Yildirim, N. C.; Yildirim, N.; Akyol, E. A.
Generally, the water quality depends on its chemical and microbiological conditions. So, in this study, the chemical and microbiological characteristics of the Perisuyu River through 4 year long surveillance in Tunceli. Turkey were studied. Sampling was carried out four times during the year. Nitrate, nitrite, ammonium concentrations, total dissolved solid, total coliform counts were determined and the presence of Escherichia coli, important water quality indicator, was tested. Generally in water samples E. coli and total coliform were found very high and nitrate, nitrite and ammonium concentrations were low. In 2008 August and 2009 February water pH was higher than the World Health Organization limit value. Electrical conductivity was higher in 2004 May, December and 2008 February.
AtıfWoS3İncele - MakaleAçık Erişim2011Scopus SJRQ3Comparison of the survival and growth performance in rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta fario) fry
Kizak, Volkan; Guner, Yusuf; Turel, Murat; Can, Erkan; Kayim, Murathan
Rainbow trout is an intensively cultured species because of their more cultivable character than brown trout. Culture of brown trout could not be expanded due to low growth performance of brown trout compared to rainbow trout. This experiment was conducted in a commercial trout farm, Aegean area (Turkey). Growth performances and survivals of rainbow and brown trouts from fry to fingerling was observed for 155 days. Growth performances, feed conversion rates (FCR) and survivals were determined. Initial weights of rainbow and brown trouts were 0.1 +/- 0.01 g. Final weights were 26.5 +/- 5.19 and 12.97 +/- 2.74 g, respectively at the end of the experiment. Survival and FCR of rainbow and brown trouts were 83.9, 80 and 0.59, 0.61% respectively. As a result, there is a similarity between these two trout species in point of survivals and FCR's although, growth performance was obviously better than brown trout in early development of rainbow trout.
AtıfWoS5OpenAlex16İncele - MakaleAçık Erişim2016Scopus SJRQ2Essential Oil Composition of Two Grammosciadium DC Species, G. platycarpum (Boiss et Hausskn) Schischk and G. macrodon Boiss (Apiaceae), from Turkey
Yüce, Ebru; Paksoy, Mehmet Yavuz; Bagci, Eyup
Purpose: To investigate and compare the essential oil composition of two Grammosciadium species obtained by hydrodistillation Methods: The essential oil of the aerial parts of two species was obtained by hydrodistillation and analyzed by gas chromatography (GC) and gas chromatography - mass spectrometry (GC-MS). Results: In G. platycarpum, twenty-seven compounds were identified representing 99.3 % of the total oil. The major constituents of the oil were limonene (28.4 %), beta-pinene (16.1 %), beta-selinene (15.9 %), delta-3-carene (11.2 %), alpha-farnesene (6.0 %) and p - cymene (4.7 %). The oil of G. macrodon contained thirty-seven components representing 94.4 % of the total oil, with caryophyllene oxide (15.9 %), germacrene - D (12.4 %), beta-caryophyllene (11.5 %), delta-3 - carene (10.1 %) and cyclohexane (4.6 %) as the main constituents. Conclusion: The essential oil composition of G. macrodon was analysed for the first time, the most abundant constituents being caryophyllene oxide, and cyclohexane.
AtıfWoS4OpenAlex3İncele - MakaleYalnız künye2017Scopus SJRQ3MONTHLY VARIABILITY OF OXIDANT AND ANTIOXIDANT BIOMARKERS OF FRESHWATER CRAYFISH (ASTACUS LEPTODACTYLUS ESCH., 1823)
Barim-Oz, Ozden; Yilmaz, Seval; Sahin, Hulya; Benzer, Fulya
In the present study was determined the effects of monthly variability on enzymatic antioxidant (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px)), antioxidant (reduced glutathione (GSH)) and the oxidant status (nitric oxide (NO), lipid peroxidation (MDA)) in hepatopancreas, muscle, gills and gonad tissues of freshwater crayfish (A. leptodactylus) the monthly collected throughout the year from Keban Dam Lake of Turkey. Results indicate that variations in oxidants and antioxidants with relation to month were not only tissue specific but also were gender specific. The levels of oxidant parameters were generally higher in hepatopancreas in comparison to muscle, gills and gonad of crayfish. Moreover, in tissues were also determined the different oxidants and antioxidants responses in moulting, mating, breeding and egg laying periods.
AtıfWoS5İncele - MakaleYalnız künye2010Scopus SJRQ3Investigation of Some Antioxidant Enzymes Activities Depending on Adrenomedullin Treatment and Cold Stress in Rat Liver Tissue
Yildirim, Nuran Cikcikoglu; Yürekli, Muhittin; Yildirim, Numan
Purpose: The aim of this study is to investigate the compensating effects of adrenomedullin on liver tissue after cold stress treatment. Materials and Methods: Male Wistar rats were divided into four groups as control, adrenomedullin, cold stress and cold stress + adrenomedullin treated. Adrenomedullin was given by intraperitoneal injection (2 mg/g body weight) once a day for a week. For cold stress the rats were kept at 10 C for a week. Catalase, glutathione peroxidase and superoxide dismutase activities were measured in liver tissue. Results: Catalase activity was decreased significantly as compared to control in adrenomedullin treated group (p<0.05). There was no significant difference in superoxide dismutase activity (p>0.05). Glutathione peroxidase activity was increased in adrenomedullin treated group but this was statistically insignificant (p>0.05). All enzyme activities were decreased by cold stress (p<0.05). In Adrenomedullin+cold stress group, only the glutathione peroxidase activity was significantly decreased (p<0.05). Conclusion: It is concluded that cold stress induces decrease in catalase, superoxide dismutase and glutathione peroxidase activities in rat liver. Adrenomedullin treatment corrected only glutathione peroxidase activity while decreasing catalase and superoxide dismutase activities further. The discrepancy may be explained by different responses of antioxidant systems to oxidative stress. It can be concluded that oxidative factors may display unexpected effects on the regulation of glutathione peroxidase activities in the adrenonmedullin case.
AtıfWoS8İncele
