Sürdürülebilir Kalkınma Amaçları
Araştırmacılar(8)
Birim yayınları
68 →- MakaleYalnız künye2026Scopus SJRQ3A new lectin from Amanita vaginata mushroom with potent anti-inflammatory activity
Seliman, Thoiba Mogahid Hussein; Ozsoy, Nurten; Altiparmak-Ulbegi, Gulsum; Alp-Kavlo, Hevidar; Arcan, Gulsah Gamze; Akev, Nuriye; Can, Ayse; Aksoy-Sagirli, Pinar
This study used 80% ammonium sulphate fractional precipitation, followed by affinity chromatography to purify a new lectin (AVL) from the crude extract of the Amanita vaginata mushroom. The purification procedure achieved a 20% yield, a specific activity of 5120 HU/mg protein, and a 16-fold increase in purity. SDS-PAGE analysis showed a single band of 45 kDa. We assessed AVL's anti-inflammatory effect by measuring levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), induced by lipopolysaccharide (LPS), in RAW 264.7 macrophages. Western blot analysis showed that iNOS and COX-2 protein levels were barely detectable in the control groups, but markedly elevated in the LPS-treated groups. However, AVL treatment significantly inhibited the expression of both iNOS and COX-2 in LPS-stimulated cells. This effect was dose-dependent. These findings suggest that AVL's anti-inflammatory effects are mediated through the suppression of iNOS and COX-2 expression.
AtıfScopus2WoS1OpenAlex2
İncele - MakaleAçık Erişim2026Scopus SJRQ2Multifunctional PLA/PHA-Based films incorporating Moluccella spinosa extract for sustainable and antimicrobial food packaging applications
Selcuk Pekdemir, Sibel; Gurler, Nedim; Yilmaz Sancar, Pelin; Karagulle, Burcu; Kok, Mediha; Pekdemir, Mustafa Ersin; Qader, Ibrahim Nazem
In this study, a novel plant-based shape memory biocomposite was developed for sustainable food packaging applications. A poly(lactic acid)/poly(hydroxyalkanoate) (PLA/PHA) blend was reinforced with the ethanolic extract of Moluccella spinosa, a plant recognized for its bioactive constituents. Structural and thermal analyses confirmed the successful incorporation of the extract without compromising the polymer matrix integrity. The results demonstrated improved barrier performance, characterized by lower water vapor permeability, reduced moisture content, and slightly increased opacity with increasing concentrations of M. spinosa extract. In addition, the composite films exhibited enhanced shape memory behavior, which became more pronounced at higher extract concentrations. Antimicrobial assays revealed a limited and selective inhibitory effect, primarily against Gram-positive bacteria (Enterococcus faecalis and Clostridium perfringens), while no notable activity was observed against Escherichia coli and Staphylococcus aureus. These findings indicate a preliminary antimicrobial potential, likely associated with a sustained-release mechanism rather than strong bactericidal activity. Overall, the integration of M. spinosa extract into the PLA/PHA matrix offers a promising route to design multifunctional, biodegradable packaging materials with shape memory capability, where antimicrobial functionality serves as a complementary feature, contributing to the advancement of environmentally friendly and active food packaging technologies.
- MakaleYalnız künye2026Scopus SJRQ2Development and Characterization of Starch/Microcrystalline Cellulose/Bentonite Intelligent Packaging Films Incorporated With Red Beet Peel Extract for Monitoring Chicken Freshness
Gürler, Nedim
This study presents the physical, mechanical, antioxidant, and application properties of films prepared by adding red beet peel extract to the starch/microcrystalline cellulose/bentonite clay polymer composites by casting method to monitor chicken breast freshness. The effects of bentonite in different proportions (0%, 1%, 5%, and 10%) were investigated. The structure of the films was elucidated by XRD, FTIR spectroscopy, and SEM for surface morphology of films. Regarding mechanical testing, the highest tensile strength starch/microcrystalline cellulose-1% bentonite film was 0.88 MPa. It was noticed that water vapor permeability (WVP) improved with the addition of bentonite. Films containing 10% bentonite clay showed a 27% decrease in water vapor permeability compared to films without clay. However, the swelling power of composites increased as the bentonite content increased. Additionally, with the addition of clay the films exhibited more opaque properties. Red beet peel extract was also incorporated to the polymer composite to monitor chicken breast freshness. The antioxidant properties of the films were accomplished using DPPH method. When red beet peel extract was incorporated into the polymer film, the highest DPPH scavenging activity increased by 50%. In summary, starch/microcrystalline cellulose/bentonite films can be used as pH-sensitive intelligent packaging for controlling the freshness of chicken breast.
- Derleme MakaleYalnız künye2026Scopus SJRQ1Assessing the Impact of Climate Change on the Sustainability of Sorghum Production: A Bibliometric Analysis
Zheng, Mingke; Tutar, Halit; Shaghaleh, Hiba; Alhaj Hamoud, Yousef; Er, Hasan; Omac, Basri; Yildirim, Gokhan; Eren, Ömer; Khalifa, Muhammad; Mwamahonje, Andekelile
Sorghum is a crucial crop for sustainable agriculture due to its drought resistance, low carbon footprint, and diverse applications in food, feed, and bioenergy. However, understanding the impact of climate change on sorghum production is essential for ensuring its future sustainability. This study conducts a comprehensive bibliometric analysis of scientific publications related to sorghum and climate change using the Web of Science (WoS) database, covering the period from 1984 to 2024. A total of 1053 relevant papers were analyzed, revealing an average annual growth rate of 12.73% and an average citation count of 32.02 per document. Most of the publications (83.5%) were research articles, while 9.7% were review papers. Among the contributing researchers, Prasad PVV emerged as the most productive author based on an h-index of 13, whereas the United States was identified as the most influential country, contributing 235 documents and 13,750 citations. Keyword clustering analysis identified five major research themes, including sustainable energy and environmental impacts, climate resilience, socioeconomic effects of climate change, and key crops. The findings of this study offer valuable scientific insights to guide future research and policymaking on climate change and sorghum sustainability.
AtıfScopus4OpenAlex3İncele - MakaleAçık Erişim2026Scopus SJRQ2Ultrasound assisted extraction of phenolic compounds from Tunceli walnut varieties using deep eutectic solvents
Aydin, Çağlar Mert
This study aimed to improve a green way to enhance extraction of bioactive compounds from walnut, and to evaluate the effect of altitude on walnut bioactive content. Total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity were evaluated as bioactive compounds of walnut. In comparison with conventional solvents (water, ethanol and methanol), three DESs (Deep eutectic solvents) were formed from choline chloride, zinc chloride, and sorbitol as HBA and ethylene glycerol as HBD. The DESs (DES-1 and DES-2) generated from choline chloride and zinc chloride exhibited better extraction efficiencies for any bioactive compound than that of conventional solvents. Especially, the DES formed from the choline chloride: ethylene glycerol demonstrated the highest extraction efficiency. However, sugar-based DES showed the worst extraction efficiency. The altitude significantly affected extracted bioactive contents from walnuts (Hozat 1000m, Ovacik 1300m and Nazimiye 1550m). Walnut’s extracted bioactive content ordinarily decreased as the altitude increased, regardless of solvent type used in extraction. The result is a light to enhancing knowledge as to DES usage and its extraction efficiency of bioactive compounds for food applications. In addition, it gives better understanding of altitude effect on the content of bioactive compounds in walnuts.
AtıfScopus1WoS1İncele - MakaleAçık Erişim2025Effects of molar ratio, temperature and water content on acidity and viscosity of deep eutectic solvent formed from Choline Chloride-Ethylene Glycerol
Aydın, Çağlar Mert
Deep eutectic solvents (DESs) become preferred solvents owing to unique features and promising environmentally friendly nature they have. Evaluation their properties is essential in order to use them effectively. Even though DESs are a good alternative to classic solvents, their viscosity is high, limiting their usage in industrial applications. However, this can be overcome by adding cosolvent or varying application conditions. In this study, the effect of temperature ranging from 200C to 600C (293.15- 333.15 K), molar ratio (1:1 to 1:9) and cosolvent addition (water) on acidity and viscosity of DES were investigated. Overall, as a result of this study, operation conditions had a significant effect on acidity and viscosity of DESs. Acidity and viscosity of DESs were on decrease as molar ratio increased, and the increase in temperature negatively affected viscosity of DESs. Dynamic viscosity of DESs were temperature dependence, following Vogel-Fulcher-Tammann (VFT) equality. Cosolvent addition decreased viscosity of DESs. Addition of water higher than 25% did not have a significant effect on viscosity. In addition, water addition decreased acidity of DES up to 1:5 molar ratio, but no significant effect regardless of the amount of water addition on the acidity was determined. These results provide a new perceptive about the mechanism of DES designed for usage in food applications.
- MakaleAçık Erişim2025Comparison of Secondary Models for Modelling the Growth of Salmonella in Leafy Greens
Omaç, Basrı
This study evaluated the performance of three mathematical models—the Ratkowsky square-root, Arrhenius-type, and Cardinal models—in describing the temperature-dependent growth of Salmonella in leafy greens. Therefore, data on the maximum growth rate (μmax) of Salmonella enterica in leafy greens under different temperature conditions were collected from peer-reviewed scientific publications available in databases. The Integrated Pathogen Modeling Program (IPMP) software was then used for modelling and analysis. The results indicated that the sub-optimal Ratkowsky model most accurately captured growth rates below the organism’s optimum temperature, with parameters a=0.02 and Tmin=7.3°C estimated with high precision. In contrast, the model’s supra-optimal parameters were weakly constrained due to limited high-temperature data. Despite achieving strong explanatory power (R2=0.90), the Arrhenius-type and Cardinal models had significant parameter uncertainty over the whole temperature range, which limited their usefulness. These findings support the use of simpler, empirically grounded models in predictive microbiology when thermal data are incomplete. Future research should prioritize gathering data at higher temperatures to better characterize growth decline in the supra-optimal range.
- MakaleAçık Erişim2025Scopus SJRQ2Evaluation effect of physicochemical properties of deep eutectic solvents on phenolic compounds extraction yield from Kultik seed
Aydin, Çağlar Mert
The aim of this study is to achieve maximum phenolic component extraction efficiency by using deep eutectic solvent, and to gain higher extraction efficiency than that obtained using conventional solvent from fruit waste, namely Kultik seed (Cucumis melo L.). Six DES (deep eutectic solvent) combination were formed using zinc chloride, ethylene glycerol, lactic acid, choline chloride, sorbitol and glucose. The evaluated DES properties were viscosity, pH, %brix and refractometric index, and their effect on phenolic extraction. Overall, the forming components significantly influence DES properties, indicating importance of choosing proper components in DES formation to receive desired extraction result. There was a correlation between extraction yield and DES properties (brix%, pH and viscosity), showing adjusting these properties are crucial in yield of desired phenolic extraction yield, r > 0.5. Alcohol based DESs had lower viscosity, higher brix% and pH in the range of 3–5. Sugar based DESs had higher viscosity, lower brix% and pH other than the range of 3–5. The highest phenolic extraction efficiency was obtained in extraction using alcohol based DESs as solvent, while the extraction using sugar and carboxylic acid based DESs underperformed. Furthermore, the extractions using some DES types (zinc chloride: ethylene glycerol (149.5 mg GAE 100 g−1), choline chloride: ethylene glycerol (161.5 mg GAE 100 g−1)) achieved better phenolic yield than that obtained using conventional solvents (water (7,6 mg GAE 100 g−1), methanol (80.2 mg GAE 100 g−1), ethanol (138.7 mg GAE 100 g−1)). These results indicate that DESs, as a green solvent, provide excellent alternative to organic solvents for green chemistry, and have a great potential to use in industrial applications involving extraction of bioactive compounds from plant sources.
- MakaleYalnız künye2025Scopus SJRQ1Effect of Ohmic Heating on the Quality and Nutrient Preservation of Plum Marmalade: A Comparison With Conventional Heating
Ekici, Seymanur; Omac, Basri; Sabanci, Serdal
In this study, plum marmalade was prepared using the ohmic heating method at three distinct voltage gradients (30, 35, and 40 V/cm). The quality properties of the marmalade prepared this way were contrasted with those prepared using the conventional heating method. Total phenolic content (TPC), antioxidant activity (AA), vitamin C content, total color change (ΔE), hydroxymethylfurfural (HMF), and the amount of time needed for the process, including heating and evaporation, were all measured as part of the study. According to the findings, ohmic heating—specifically, a voltage gradient of 40 V/cm—significantly reduced the heating time when compared to the traditional method, which raised the stability of vitamin C, AA, and phenolic compounds. When ohmic heating was used instead of conventional heating, the amounts of TPC, AA, and vitamin C increased by 19.50%, 33.90%, and 149.12%, respectively. In comparison to traditional heating under atmospheric conditions, the results also showed that ohmic heating increased the amounts of gallic acid (40.61%), catechin (40.98%), chlorogenic acid (25.05%), and rutin (24.67%). Furthermore, the results showed that ohmic heating reduced the amount of HMF (34.34%) and ΔE (2.27%) in comparison to conventional heating. TPC, AA, vitamin C, gallic acid, catechin, chlorogenic acid, and rutin were higher than conventional heating; nevertheless, HMF and ΔE were lower than conventional heating at the applied ohmic heating process. The results obtained indicate a strong potential for an ohmic heating system as a rapid heating method for preserving nutritional value.
AtıfScopus6WoS5OpenAlex6İncele - MakaleYalnız künye2025Scopus SJRQ2Evaluation of Nano-Zinc Borate Effects on Thermal Properties, Morphology, Antibacterial Activity, and Drug Release Behavior of Starch/Gelatin Hydrogel Films for Biomedical Applications
Koçak, Berna; Gürler, Nedim; İpek, Yeliz; Yazdıç, Ferit Can; Karaman, Altuğ
Starch and gelatin offer opportunities for use due to their non-toxicity, biocompatibility, physical and functional properties. In this study, different amounts of nano-zinc borate were added to starch/gelatin composition for biological applications and their properties were studied. The structure of the films was investigated by various techniques. Nanostructured zinc borate was synthesized using a chemical method and particle sizes were determined as 196 nm. The atenolol drug was doped into the polymer composite. The atenolol release was performed at pH 7.4 and in phosphate-buffered saline solution medium. Cumulative drug release was 76% with the inclusion of nano-zinc borate in the polymer mixture. The atenolol release was approximately 50%–70% in films with nano-zinc borate added after 300 min. Furthermore, thermal resistance of the films improved with the addition of nano-zinc borate. The investigated chemical compound exhibited pronounced antibacterial activity against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus), with significantly greater potency compared to Gram-negative bacteria (E. coli and Pseudomonas aeruginosa). Notably, the formulation containing 1.5% starch, 0.5% gelatin, and 1% nano-zinc borate demonstrated broad-spectrum efficacy against all tested pathogens, highlighting its potential as a promising antibacterial agent. The observed differential activity against bacterial strains suggests that fine-tuning the concentrations of starch, gelatin, and nano-zinc borate may optimize antibacterial efficacy and broaden the spectrum. The results showed us that non-toxic and biocompatible polymer films can be realized in pharmaceutical industry systems and biomedical applications.
Tam Kayıt
| Alan | Değer | Dil |
|---|---|---|
| dc.date.accessioned | 2026-10-28T14:33:31.206020857Z | |
| dc.date.available | 2026-10-28T14:33:31.206020857Z | |
| dc.identifier.uri | https://rdlopen.rawdatalibrary.net/r/munzur/116 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.title | Gıda İşleme Bölümü | tr |
| dc.title | Department of Food Processing | en |
| organization.identifier.code | munzur-tunceli-gida-isleme | |
| organization.unitType | department | |
| rdl.unit.alias | \bgida isleme bolumu\b | |
| rdl.unit.alias | \bfood process(ing)?\b |