Sürdürülebilir Kalkınma Amaçları

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• Derleme MakaleAçık Erişim2022Scopus SJRQ4/r/munzur/2927
  Multifunctional role of Nobiletin in cancer chemoprevention

  Malik, Durr-E-Shahwar; Attar, Rukset; Ozbey, Ulku; Romero, Mirna Azalea; Yulaevna, Ishmuratova Margarita; Purenovic, Jelena

  The diversity of highly bioactive and pharmacologically active natural products which recognize essential biological targets having exquisite specificity, constitutes a massive pharmacological database for discovery of valuable drugs. The rapid accumulation of information has revealed chemopreventive role of nobiletin against wide variety of cancers. Recent efforts are now being expanded and new integrative omics technologies have illuminated continuously upgrading list of molecular mechanisms which underlie carcinogenesis and metastasis. In this mini-review, we explore the progress that has been made in the identification of promising molecular targets of nobiletin.

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  AtıfScopus5·OpenAlex4

  İncele
• Kitap BölümüYalnız künye2022/r/munzur/2425
  Metastasis inhibitory role of blueberries: time to play gooseberry with oncogenic cascades and metastasis

  Farooqi, Ammad Ahmad; Ozbey, Ulku; Pimentel, Tatiana Colombo; Attar, Rukset

  The magical little fruits have started to gain attention because of their cancer chemopreventive roles against different cancers. More recently, cancer inhibitory properties of blueberry extracts and isolated bioactive constituents have been described that provide new mechanistic insights. However, there are visible knowledge gaps in our understanding about metastasis inhibitory role of blueberries in xenografted mice. Despite mainstream popularization of cancer chemopreventive role of blueberries, many questions remain about their precise role in the regulation of deregulated oncogenic cascades in metastasis. It will be really exciting to consider how new scientific breakthroughs in future might propel the science of nutrigenomics to a more sophisticated level of inquiry.

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  AtıfScopus2·OpenAlex1

  İncele
• MakaleAçık Erişim2021Scopus SJRQ4/r/munzur/3592
  Regulation of cell signaling pathways by Wogonin in different cancers: Mechanistic review

  Butt, Ghazala; Ozbey, Ulku; Malik, Durrshahwar; Attar, Rukset; Youssef, Lara; Farooqi, Ammad Ahmad

  Natural products have historically been invaluable as a premium source of therapeutic agents. Recent advancements in genomics and structural biology have portrayed a high-resolution landscape of the diversity of proteins targeted by pharmacologically active products from natural sources. Natural product research has generated valuable wealth of information and cutting-edge research-works have leveraged our conceptual knowledge altogether to a new level. Wogonin (5,7-dihydroxy-8-methoxyflavone) is an O-methylated flavone and has attracted noteworthy appreciation because of its ability to pharmacologically target plethora of cell signaling pathways in different cancers. In this mini-review, we have gathered scattered pieces of available scientific evidence to summarize how wogonin pharmaceutically targeted Wnt/β-catenin, JAK/STAT, VEGF/VEGFR and TRAIL-driven apoptotic pathways in wide variety of cancers. We have also critically analyzed how wogonin prevented carcinogenesis and metastasis in tumor-bearing mice. Although researchers have uncovered pleiotropic role of wogonin in the regulation of different oncogenic signaling cascades but there are visible knowledge gaps in our understanding related to regulation of non-coding RNAs by wogonin. Future studies must converge on the unraveling of additional drug targets for wogonin to achieve a fuller and realistic understanding of the chemopreventive properties of wogonin.

  AtıfScopus5·WoS6

  İncele
• MakaleYalnız künye2019Scopus SJRQ2/r/munzur/3687
  Regulation of signaling pathways by β-elemene in cancer progression and metastasis

  Qureshi, Muhammad Z.; Attar, Rukset; Romero, Mirna A.; Sabitaliyevich, Uteuliyev Y.; Nurmurzayevich, Sadykov B.; Ozturk, Ozlem; Wakim, Lara H.; Lin, Xiukun; Ozbey, Ulku; Yelekenova, Armida Bakhytbekovna

  Entry of β-elemene into various phases of clinical trials advocates its significance as a premium candidate likely to gain access to mainstream medicine. Based on the insights gleaned from decades of research, it seems increasingly transparent that β-elemene has shown significant ability to modulate multiple cell signaling pathways in different cancers. We partition this multicomponent review into how β-elemene strategically modulates various signal transduction cascades. We have individually summarized regulation of tumor necrosis factor related apoptosis-inducing ligand, signal transducers and activators of transcription, transforming growth factor/SMAD, NOTCH, and mammalian target of rapamycin pathways by β-elemene. Last, we will discuss the results of clinical trials of β-elemene and how effectively we can use these findings to stratify patients who can benefit most from β-elemene.

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  AtıfScopus33·OpenAlex33

  İncele
• MakaleYalnız künye2019Scopus SJRQ2/r/munzur/3654
  Apigenin as an effective anticancer natural product: Spotlight on TRAIL, WNT/β-catenin, JAK-STAT pathways, and microRNAs

  Ozbey, Ulku; Attar, Rukset; Romero, Mirna Azalea; Alhewairini, Saleh S; Afshar, Behnaz; Uteuliev, Yerzhan Sabitaliyevich; Hanna-Wakim, Lara; Ozcelik, Beraat; Farooqi, Ammad Ahmad

  Wealth of information gleaned from decades of high-impact research work; scientists have disentangled the complicated web of versatile regulators that underlie cancer development and progression. Use of structural biology approaches and functional genomics have helped us to gain new insights into complex nature of cancer, and it is now clear that genetic/epigenetic mutations, overexpression of oncogenes, inactivation of tumor suppressors, loss of apoptosis, and versatility of protein binding partners have contributory roles in carcinogenesis and metastatic spread. It is becoming progressively more understandable that reprogramming of gene expression during and nontranscriptional changes during cancer development and progression are initiated and controlled by deregulated signal transduction cascades, all of which collectively create an incalculable complexity. Data obtained through preclinical and clinical trials revealed that alterations in the targeted oncogenes and other downstream, and parallel pathways played a central role in the development of resistance against different therapeutics. Phytochemicals have regained limelight, and different natural products are currently being tested for efficacy in preclinical studies. Apigenin, a plant-derived flavonoid has considerable pharmacological value and is reportedly involved in the regulation of different signaling cascades. In this review, we have attempted to summarize rapidly evolving understanding of molecular biologists and pharmacologists about the potential of apigenin in the regulation of deregulated signaling pathways in different cancers. We have emphasized on the regulation of WNT/β-catenin and janus kinase/signal transducers and activators of transcription (JAK-STAT) pathways. We also comprehensively discuss how apigenin restored apoptosis in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant cancers. The review also gives a snapshot of microRNAs (miRNAs) that regulate wide-ranging biological processes, and it is now clear that each miRNA can control hundreds of gene targets. Apigenin was noted to upregulate miR-520b and miR-101 in different cancers to inhibit tumor growth. Moreover, apigenin-induced apoptotic rate was significantly higher when used in combination with miR-423-5p inhibitors or miR-138 mimics. Better comprehension of linear and integrated signaling pathways will be helpful in effective therapeutic targeting of deregulated signaling pathways to inhibit/prevent cancer.

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  AtıfScopus65·OpenAlex66

  İncele
• Kitap BölümüYalnız künye2019Scopus SJRQ2/r/munzur/3264
  TRAIL Mediated Signaling in Breast Cancer: Awakening Guardian Angel to Induce Apoptosis and Overcome Drug Resistance

  Yin, Ning; Yi, Liu; Khalid, Sumbul; Ozbey, Ulku; Uteuliev, Yerzhan Sabitaliyevich; Farooqi, Ammad Ahmad

  Sequencing technologies have allowed us to characterize highly heterogeneous molecular landscape of breast cancer with unprecedented details. Tremendous breakthroughs have been made in unraveling contributory role of signaling pathways in breast cancer development and progression. It is becoming progressively more understandable that deregulation of spatio-temporally controlled pathways underlie development of resistance against different drugs. TRAIL mediated signaling has attracted considerable appreciation because of its characteristically unique ability to target cancer cells while leaving normal cells intact. Discovery of TRAIL was considered as a paradigm shift in molecular oncology because of its conspicuous ability to selectively target cancer cells. There was an exponential growth in the number of high-quality reports which highlighted cancer targeting ability of TRAIL and scientists worked on the development of TRAIL-based therapeutics and death receptor targeting agonistic antibodies to treat cancer. However, later studies challenged simplistic view related to tumor targeting ability of TRAIL. Detailed mechanistic insights revealed that overexpression of anti-apoptotic proteins, inactivation of pro-apoptotic proteins and downregulation of death receptors were instrumental in impairing apoptosis in cancer cells. Therefore researchers started to give attention to identification of methodologies and strategies to overcome the stumbling blocks associated with TRAIL-based therapeutics. Subsequent studies gave us a clear picture of signaling cascade of TRAIL and how deregulation of different proteins abrogated apoptosis. In this chapter we have attempted to provide an overview of the TRAIL induced signaling, list of proteins frequently deregulated and modern approaches to strategically restore apoptosis in TRAIL–resistant breast cancers.

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  AtıfScopus6·WoS7·OpenAlex7

  İncele
• MakaleAçık Erişim2018Scopus SJRQ3/r/munzur/3565
  Maslinic acid as an effective anticancer agent

  Lin, Xiukun; Ozbey, Ulku; Uteuliyev, Yerzhan Sabitaliyevich; Attar, Rukset; Ozcelik, Beraat; Zhang, Yuanyan; Guo, Mingyue; Liu, Minghua; Alhewairini, Saleh S.; Farooqi, Ammad Ahmad

  Maslinic acid (2α,3β-dihydroxyolean-12-en-28-oic acid) is a naturally occurring pentacyclic triterpenic compound. Maslinic acid is gradually gaining attention as an excellent pharmacologically active product because of its premium biological properties. In this review we will focus on chemopreventive properties of Maslinic acid against different cancers. Seemingly, available data is limited and we have yet to unravel how Maslinic acid therapeutically targeted oncogenic cell signal transduction cascades in different cancers. Moreover, there are visible knowledge gaps about the ability of Maslinic acid to modulate oncogenic and tumor suppressor microRNAs in various cancers.

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  AtıfScopus20·OpenAlex17

  İncele
• MakaleYalnız künye2017Scopus SJRQ2/r/munzur/3872
  Investigation of blood antioxidant enzyme levels and glutathione peroxidase, catalase, and superoxide dismutase gene polymorphism in sheep with fluorosis

  Ozbey, Ulku; Deger, Yeter; Yur, Fatmagul; Çambay, Zafer; Ozbeye, Gokben

  Reactive oxygen species have been considered to play a significant part in the development of fluorosis, a critical public health issue in many parts of the world. OBJECTIVES: The aims of this study, conducted on two groups of sheep, with and without fluorosis, was (i) to determine the effect of fluorosis on antioxidant enzymes, such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and on malondialdehyde (MDA); and (ii) to investigate the relationship between the SOD, CAT, and GSH-Px genotypes and the antioxidant enzyme levels. METHODS: The two groups of sheep were: (i) 24 Akkaraman sheep with fluorosis living in Dogubeyazit province of Agri and (ii) 20 Akkaraman sheep with no signs of fluorosis living in Van. The MDA level and the antioxidant enzyme activities were identified spectrophometrically. The genotype characteristics were determined by the PCR-RFLP method using DNA extracted from blood. RESULTS: Compared to the control sheep without fluorosis, we found in the fluorotic sheep: (i) an increase in plasma MDA levels and GSH-Px-1 activity (p<0.05), and (ii) a decrease in SOD and CAT activities (p<0.01). There were significant differences found in the genotype and allele frequencies in both groups (p<0.01). CONCLUSIONS: Fluoride-induced oxidative stress affected the membrane structure resulting in elevated erythrocyte MDA levels and reduced enzyme activity of the enzymes SOD and CAT. According to our data, the gene polymorphisms show a tendency towards fluorosis for our local sheep population.

  AtıfScopus5

  İncele
• Derleme MakaleYayıncıda açık erişim2017Scopus SJRQ3/r/munzur/3844
  Regulation of signaling pathways by tanshinones in different cancers

  Lin, X.; Qureshi, M.Z.; Romero, M.A.; Khalid, S.; Aras, A.; Ozbey, U.; Farooqi, A.A.

  Past several years have witnessed dramatic leaps in our understanding of rewiring of gene expression at the translation level during cancer developmentthat provides linchpin support to the transformed phenotype. Most recent and ground-breaking developments in the field of molecular oncology aredriven by an explosion in technological advancements and have started to reveal previously unimagined regulatory mechanisms and how they intricately co-ordinate to modulate cancer progression, loss of apoptosis and development of resistance against different therapeutics. However, the insights gained from work in this natural product research have far-reaching impact because of rapidly increasing repertoire of medicinally and biologically efficient phytochemicals. How Tanshinones mediate targeting of JAK-STAT, ER stress associated signaling cascade,PI3K/AKT/mTOR pathway,autophagy, TRAIL pathway and microRNAs are being discovered and will prove to be helpful in getting a step closer to personalized medicine.

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  AtıfScopus12·OpenAlex12

  İncele
• MakaleYalnız künye2017Scopus SJRQ2/r/munzur/3843
  Seasonal prevalence of Escherichia coli O157:H7, Listeria spp. and Salmonella spp. in fermented sausages, sosis and salami in eastern Turkey

  Ozbey, Gokben; Ozbey, Ulku; Kok, Filiz

  The goal of our study was to characterize the proportions and seasonal prevalence of Escherichia coli (E. coli) O157:H7, Listeria spp. and Salmonella spp. in fermented sausages, sosis and salami. A total of 192 samples consisting of sausage (n=96), sosis (n=48) and salami (n=48) purchased from different butcher shops and markets in the Elazig Province of eastern Turkey for one year duration were processed and tested by culture and polymerase chain reaction (PCR) for the presence of E. coli O157:H7, Listeria spp. and Salmonella spp. L. innocua was found to be the most predominant Listeria spp. in fermented sausages and sosis whereas, L. monocytogenes (1.04%) and Salmonella spp. (1.04%) were detected at much lower prevalence in fermented sausage. No L. monocytogenes and Salmonella spp. were determined in salami samples. In addition, no Salmonella spp. was detected in sosis samples. L. welshimeri (12.5%) was observed most frequently on salami samples. No E. coli O157:H7 was isolated in any samples of fermented sausage, sosis and salami. Seasonal prevalence of Listeria spp. in fermented sausages, sosis and salami was highest in July, with no L. monocytogenes and Salmonella spp. being isolated during autumn, winter and spring months of the year. Although the proportion of L. monocytogenes in fermented sausages and sosis is much lower in the current study, the presence of L. monocytogenes in these samples in the Elazig Province of eastern Turkey could still present a major public health threat.

  AtıfScopus3

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