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- MakaleYalnız künye2017Scopus SJRQ2Anticancer and Cytotoxic Activities of [Cu(C6H16N2O2)2][Ni(CN)4] and [Cu(C6H16N2O2) Pd(CN)4] Cyanidometallate Compounds on HT29, HeLa, C6 and Vero Cell Lines
Aydin, Ali; Korkmaz, Sengul Aslan; Demir, Veysel; Tekin, Saban
Background: In cancer, apoptosis relevant proteins-such as CaM kinase, Bcl-2 or P53, topoisomerase I, cell migration feature and DNA/BSA-macromolecules represent significant targets for current chemotherapeutics. Objective: We recently reported two coordination compounds-[Cu(C6H16N2O2)(2)][Ni(CN)(4)] (1) and [Cu(C6H16 N2O2) Pd(CN)(4)] (2)-together with their IR spectra, magnetic properties, thermal analyses and crystal structures. Herein, we describe the ability of these complexes to induce apoptosis in relevant proteins and stimulate topoisomerase I activity, cell migration velocity and DNA/BSA binding properties. Method: The in vitro antiproliferative effects and cell toxicity of both compounds were investigated through pharmacological measurement techniques, and interactions between both compounds and CT-DNA/BSA were studied with UV-Vis spectroscopy and fluorescence spectroscopy. Results & Conclusion: Studies on cells revealed that 2 (i) demonstrated a high antiproliferative effect, which was higher toward HeLa and C6 cancer cells than toward healthy Vero cells; (ii) impaired the migration of HeLa cells; (iii) altered the P53-Bcl-2 ratio in favor of apoptosis; (iv) strongly bound to DNA/BSA macromolecules; and (v) inhibited human topoisomerase I and KpnI or BamHI restriction endonucleases. In conclusion, this preliminary information demonstrates that 2 may represent a promising antiproliferative agent and a potential candidate for a therapeutic approach against HeLa.
AtıfWoS3OpenAlex4
İncele - MakaleYalnız künye2016Scopus SJRQ4Synthesis and Chemical Structure Elucidation of Two Schiff Base Ligands, Their Iron(II) and Zinc(II) Complexes, and Antiradical, Antimicrobial, Antioxidant Properties
Turan, Nevin; Savci, Ahmet; Buldurun, Kenan; Alan, Yusuf; Adigüzel, Ragip
Fe(II) and Zn(II) complex series have been synthesized from Schiff base ligands derived from furan-2-carbaldehyde and thiophene-2-carbaldehyde. Elemental, infrared, ultra-violet- visible, NMR and thermal analysis, also mass spectroscopy and magnetic susceptibility measurements were performed to explain the structures of these synthesized ligands and their metal complexes. The formulas based on analytical, spectral, and magnetic studies, the complexes can be demonstrated as [M(L-1)(2)](H2O)(n), [M(L-2)(2)](H2O)(n), where M = Zn(II) and Fe(II). An octahedral geometry was suggested for the Zn(II) and Fe(II) complexes. The antioxidant, antiradical and antimicrobial properties of the Zn(II) and Fe(II) complexes were investigated using different in vitro assays. Some of the complexes showed reasonable amount of antioxidant and antimicrobial activity.
AtıfWoS19OpenAlex19İncele - DergiANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
- DergiLETTERS IN ORGANIC CHEMISTRY