Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Camas, Anil Sazak(4)
- Camas, Mustafa(4)
- Deng, Hai(4)
- Jaspars, Marcel(4)
- Kwain, Samuel(4)
- Kyeremeh, Kwaku(4)
- Dofuor, Aboagye Kwarteng(3)
- Tetevi, Gilbert Mawuli(3)
- Azerigyik, Faustus Akankperiwen(2)
- Celik, Erkan(2)
- Gul, Muhammet(2)
- Mensah, Thomas(2)
- Aktumsek, Abdurrahman(1)
- Alexandru-Crivac, Cristina-Nicoleta(1)
- Anang, Abraham Kwabena(1)
- Artuğer, Firat(1)
- Ayna, Adnan(1)
- Blaschke, Thomas(1)
- Cakilcioglu, Ugur(1)
- Custodio, Luisa(1)
- Cziáky, Zoltán(1)
- Farooq, Danish(1)
- Gallo, Monica(1)
- Ghorbanzadeh, Omid(1)
- Jekő, József(1)
- Kismet, Yilmaz(1)
- Mahomoodally, Mohamad Fawzi(1)
- Mawuli, Gilbert Tetevi(1)
- Mete, Suleyman(1)
- Montesano, Domenico(1)
- Moslem, Sarbast(1)
- Ohashi, Mitsuko(1)
- Oluwabusola, Emmanuel(1)
- Osei, Enoch(1)
- Owusu, Kofi Baffour-Awuah(1)
- Picot-Allain, Carene(1)
- Polat, Rıdvan(1)
- Rodrigues, Maria João(1)
- Serin, Faruk(1)
- Yucesan, Melih(1)
Yayınlar
- MakaleAçık Erişim2021Scopus SJRQ1Chemical profiling and biological evaluation of nepeta baytopii extracts and essential oil: An endemic plant from turkey
Zengin, Gokhan; Mahomoodally, Mohamad Fawzi; Aktumsek, Abdurrahman; Jekő, József; Cziáky, Zoltán; Rodrigues, Maria João; Custodio, Luisa; Polat, Rıdvan; Cakilcioglu, Ugur; Ayna, Adnan
Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g) and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40 and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and 129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the methanol and water extracts. The results obtained from this study highlighted that the abundance of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and therefore should be investigated further.
AtıfScopus32OpenAlex32
İncele - MakaleAçık Erişim2020Scopus SJRQ2Generalized quasi-einstein manifolds in contact geometry
Ünal, Inan
In this study, we investigate generalized quasi-Einstein normal metric contact pair manifolds. Initially, we deal with the elementary properties and existence of generalized quasi-Einstein normal metric contact pair manifolds. Later, we explore the generalized quasi-constant curvature of normal metric contact pair manifolds. It is proved that a normal metric contact pair manifold with generalized quasi-constant curvature is a generalized quasi-Einstein manifold. Normal metric contact pair manifolds satisfying cyclic parallel Ricci tensor and the Codazzi type of Ricci tensor are considered, and further prove that a generalized quasi-Einstein normal metric contact pair manifold does not satisfy Codazzi type of Ricci tensor. Finally, we characterize normal metric contact pair manifolds satisfying certain curvature conditions related toM-projective, conformal, and concircular curvature tensors. We show that a normal metric contact pair manifold with generalized quasi-constant curvature is locally isometric to the Hopf manifold S2n+1(1) x S1.
AtıfScopus5WoS3OpenAlex4İncele - MakaleAçık Erişim2020Scopus SJRQ2A novel method for performance improvement of chaos-based substitution boxes
Artuğer, Firat; Özkaynak, Fatih
Symmetry plays an important role in nonlinear system theory. In particular, it offers several methods by which to understand and model the chaotic behavior of mathematical, physical and biological systems. This study examines chaotic behavior in the field of information security. A novel method is proposed to improve the performance of chaos-based substitution box structures. Substitution box structures have a special role in block cipher algorithms, since they are the only nonlinear components in substitution permutation network architectures. However, the substitution box structures used in modern block encryption algorithms contain various vulnerabilities to side-channel attacks. Recent studies have shown that chaos-based designs can offer a variety of opportunities to prevent side-channel attacks. However, the problem of chaos-based designs is that substitution box performance criteria are worse than designs based on mathematical transformation. In this study, a postprocessing algorithm is proposed to improve the performance of chaos-based designs. The analysis results show that the proposed method can improve the performance criteria. The importance of these results is that chaos-based designs may offer opportunities for other practical applications in addition to the prevention of side-channel attacks.
AtıfScopus55WoS44OpenAlex56İncele - MakaleAçık Erişim2020Scopus SJRQ2An integrated approach of best-worst method (bwm) and triangular fuzzy sets for evaluating driver behavior factors related to road safety
Moslem, Sarbast; Gul, Muhammet; Farooq, Danish; Celik, Erkan; Ghorbanzadeh, Omid; Blaschke, Thomas
Driver behavior plays a major role in road safety because it is considered as a significant argument in traffic accident avoidance. Drivers mostly face various risky driving factors which lead to fatal accidents or serious injury. This study aims to evaluate and prioritize the significant driver behavior factors related to road safety. In this regard, we integrated a decision-making model of the Best-Worst Method (BWM) with the triangular fuzzy sets as a solution for optimizing our complex decision-making problem, which is associated with uncertainty and ambiguity. Driving characteristics are different in different driving situations which indicate the ambiguous and complex attitude of individuals, and decision-makers (DMs) need to improve the reliability of the decision. Since the crisp values of factors may be inadequate to model the real-world problem considering the vagueness and the ambiguity, and providing the pairwise comparisons with the requirement of less compared data, the BWM integrated with triangular fuzzy sets is used in the study to evaluate risky driver behavior factors for a designed three-level hierarchical structure. The model results provide the most significant driver behavior factors that influence road safety for each level based on evaluator responses on the Driver Behavior Questionnaire (DBQ). Moreover, the model generates a more consistent decision process by the new consistency ratio of F-BWM. An adaptable application process from the model is also generated for future attempts.
AtıfScopus96WoS83OpenAlex93İncele - MakaleAçık Erişim2019Scopus SJRQ4α-D-glucopyranosyl-(1→2)-[6-O-(L-tryptophanyl)-β-D-fructofuranoside]
Kyeremeh, Kwaku; Kwain, Samuel; Tetevi, Gilbert Mawuli; Camas, Anil Sazak; Camas, Mustafa; Dofuor, Aboagye Kwarteng; Deng, Hai; Jaspars, Marcel
The Mycobacterium sp. BRS2A-AR2 is an endophyte of the mangrove plant Rhizophora racemosa G. Mey., which grows along the banks of the River Butre, in theWestern Region of Ghana. Chemical profiling using 1H-NMR and HRESI-LC-MS of fermentation extracts produced by the strain led to the isolation of the new compound, α-D-Glucopyranosyl-(1→2)-[6-O-(L-tryptophanyl)-β- D-fructofuranoside] or simply tortomycoglycoside (1). Compound 1 is an aminoglycoside consisting of a tryptophan moiety esterified to a disaccharide made up of β-D-fructofuranose and α-D-glucopyranose sugars. The full structure of 1 was determined using UV, IR, 1D, 2D-NMR and HRESI-LC-MS data. When tested against Trypanosoma brucei subsp. brucei, the parasite responsible for Human African Trypanosomiasis in sub-Saharan Africa, 1 (IC50 11.25 µM) was just as effective as Coptis japonica (Thunb.) Makino. (IC50 8.20 µM). The extract of Coptis japonica (Thunb.) Makino. is routinely used as laboratory standard due to its powerful antitrypanosomal activity. It is possible that, compound 1 interferes with the normal uptake and metabolism of tryptophan in the T. brucei subsp. brucei parasite.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2019Scopus SJRQ4Digyaindoleacid A: 2-(1-(4-hydroxyphenyl)-3-oxobut-1-en-2-yloxy)-3-(1H-indol-3-yl)propanoic acid, a novel indole alkaloid
Kwain, Samuel; Tetevi, Gilbert Mawuli; Mensah, Thomas; Camas, Anil Sazak; Camas, Mustafa; Dofuor, Aboagye Kwarteng; Azerigyik, Faustus Akankperiwen; Deng, Hai; Jaspars, Marcel; Kyeremeh, Kwaku
Digyaindoleacid A (1) is one of the novel alkaloids produced by the Ghanaian Paenibacillus sp. DE2SH (GenBank Accession Number: MH091697) isolated from the mangrove rhizosphere soils of the Pterocarpus santalinoides tree growing in the wetlands of the Digya National Park, Brong Ahafo Region, Ghana. This compound was isolated on HPLC at tR ≈ 60 min and its structure determined by MS, 1D, and 2D-NMR data. When tested against Trypanosoma brucei subsp. brucei strain 927/4 GUTat10.1, 1 produced a half-maximal inhibitory concentration (IC50) 5.21 µM compared to the standard diminazene aceturate (IC50 = 1.86 µM). In the presence of normal mouse macrophages RAW 264.7, 1 displayed a higher selectivity towards T. brucei subsp. brucei (selectivity indices (SI) = 30.2) with low toxicity. This result is interesting given that the drug diminazene aceturate is considerably toxic and 1 is a natural product isolate. The structure of 1 incorporates the backbone of the amino acid tryptophan which is crucial in the metabolism of Trypanosoma brucei subsp. brucei strain 927/4 GUTat10.1. It is possible that 1, could interfere with the normal uptake and metabolism of tryptophan in the parasite. However, 1 (IC50 = 135.41 µM) produced weak antileishmanial activity when tested against Leishmania donovani (Laveran and Mesnil) Ross (D10).
AtıfScopus4WoS3OpenAlex4İncele - MakaleAçık Erişim2019Scopus SJRQ4Paenidigyamycin g: 1-acetyl-2,4-dimethyl-3-phenethyl-1H-imidazol-3-ium
Tetevi, Gilbert Mawuli; Kwain, Samuel; Mensah, Thomas; Camas, Anil Sazak; Camas, Mustafa; Dofuor, Aboagye Kwarteng; Azerigyik, Faustus Akankperiwen; Oluwabusola, Emmanuel; Deng, Hai; Jaspars, Marcel
The Ghanaian Paenibacillus sp. DE2SH (GenBank Accession Number: MH091697) is a prolific producer of potent antiparasitic alkaloids. Further detailed study of the culture broth of this strain produced the compound Paenidigyamycin G (1), which is a derivative of the known antiparasitic compound Paenidigyamycin A (2). Compound (1) was isolated on HPLC at tR ≈ 37.5 min and its structure determined by IR, UV, MS, 1D, and 2D-NMR data. Compound 1 produced weak to moderate antileishmanial and antitrypanosomal activity when tested against Leishmania donovani (Laveran and Mesnil) Ross (D10) and Trypanosoma brucei subsp. brucei strain GUTat 3.1 with IC50 = 115.41 and 28.75 µM, respectively. This result is interesting since the parent compound 2 is known to possess consistent and potent antiparasitic activity. However, 1 displayed a promising selectivity profile towards T. brucei subsp. brucei due to its relatively low toxicity against normal mouse macrophages RAW 264.7 cells (SI = 8.70). Given that compound 1 is also the main metabolite found in the hexane fraction of all extracts produced by Paenibacillus sp. DE2SH when it is co-cultured with other bacteria strains, it must possess some unique biological functions which should make it an excellent candidate for further biological activity screening in other bioassays.
AtıfScopus4WoS3OpenAlex4İncele - MakaleAçık Erişim2019Scopus SJRQ2Paenidigyamycin A, potent antiparasitic imidazole alkaloid from the ghanaian Paenibacillus sp. De2Sh
Osei, Enoch; Kwain, Samuel; Mawuli, Gilbert Tetevi; Anang, Abraham Kwabena; Owusu, Kofi Baffour-Awuah; Camas, Mustafa; Camas, Anil Sazak; Ohashi, Mitsuko; Alexandru-Crivac, Cristina-Nicoleta; Deng, Hai
A new alkaloid paenidigyamycin A (1) was obtained from the novel Ghanaian Paenibacillus sp. isolated from the mangrove rhizosphere soils of the Pterocarpus santalinoides tree growing in the wetlands of the Digya National Park, Ghana. Compound 1 was isolated on HPLC at tR = 37.0 min and its structure determined by MS, 1D, and 2D-NMR data. When tested against L. major, 1 (IC50 0.75 µM) was just as effective as amphotericin B (IC50 0.31 µM). Against L. donovani, 1 (IC50 7.02 µM) was twenty-two times less active than amphotericin B (IC50 0.32 µM), reinforcing the unique effectiveness of 1 against L. major. For T. brucei brucei, 1 (IC50 0.78 µM) was ten times more active than the laboratory standard Coptis japonica (IC50 8.20 µM). The IC50 of 9.08 µM for 1 against P. falciparum 3d7 compared to artesunate (IC50 36 nM) was not strong, but this result suggests the possibility of using the paenidigyamycin scaffold for the development of potent antimalarial drugs. Against cercariae, 1 showed high anticercaricidal activity compared to artesunate. The minimal lethal concentration (MLC) and minimal effective concentration (MEC) of the compound were 25 and 6.25 µM, respectively, while artesunate was needed in higher quantities to produce such results. However, 1 (IC50 > 100 µM) was not active against T. mobilensis.
AtıfScopus32OpenAlex32İncele - MakaleYayıncıda açık erişim2019Scopus SJRQ3An integrated best-worst and interval type-2 fuzzy TOPSIS methodology for green supplier selection
Yucesan, Melih; Mete, Suleyman; Serin, Faruk; Celik, Erkan; Gul, Muhammet
Supplier selection is one of the most important multi-criteria decision-making (MCDM) problems for decision-makers in the competitive market. Today's organizations are seeking new ways to reduce the negative effects they have on the environment and to achieve a greener system. Currently, the concept of green supplier selection has gained great importance for its ability to incorporate environmental or green criteria into classical supplier selection practices. Therefore, in this study, a multi-phase MCDM model based on the best-worst method (BWM) and the interval type-2 fuzzy technique for order preference by similarity to ideal solution (IT2F TOPSIS) is proposed. A case study in a plastic injection molding facility in Turkey was carried out to show the applicability of the proposed integrated methodology. The paper offers insights into decision-making, methodology, and managerial implications. Results of the case study are examined and suggestions for future research are provided.
AtıfScopus93WoS85OpenAlex98İncele - MakaleAçık Erişim2017Scopus SJRQ1Change of mechanical properties of powder recyclate reinforced polyolefin based on gamma radiation
Kismet, Yilmaz
In this study, the changes observed in the mechanical properties of standard test specimens that were produced with powder coating reinforced polyolefin (polyethylene and polypropylene) due to gamma radiation were examined. Matrix material of these specimens included low density polyethylene and polypropylene and 5%, 10%, 20%, 30%, 40% and 50% electrostatic powder coating waste by weight, and the samples were exposed to 44 kGry gamma-radiation for twenty four hours. Mechanical tests applied to the specimens after radiation demonstrated that the physical bonding mechanism between matrix material and filler material was reinforced. In the mechanical tests, tensile strength, three-point bending strength, and Izod impact strength of the samples were investigated and the results were compared to the results obtained in the mechanical tests when they were not radiated. Thus, the effects of gamma radiation on the mechanical properties of the filler material, and the electrostatic powder coating reinforced polyethylene and polypropylene were determined. Furthermore, section images of the radiated samples were taken with a scanning electron microscope and compared to the section images of irradiated samples to observe the physical bonding mechanism.
AtıfScopus12WoS12OpenAlex15İncele - DergiPolymers
- DergiMolBank
- DergiMarine Drugs