Sürdürülebilir Kalkınma Amaçları

Yazarlar

  • MakaleYalnız künye2022Scopus SJRQ2
    Fault location method on two-terminal transmission line using synchronized time information of traveling waves

    Akmaz, Düzgün; Mamiş, Mehmet Salih

    In this study, approximate derivative (AD) signal processing method using synchronous voltages data, based on the traveling wave theory, was developed to determine fault locations in transmission lines. The first aerial mode voltage signals were obtained by applying the Clarke transformation to the voltage signals that occur after a short circuit fault. Then, by taking the first AD of the aerial mode voltage signals, the traveling waves were obtained. Finally, the location of the fault was found by using the time difference information of the traveling waves, wave velocity value and transmission line length. The proposed signal processing method was found to be effective in determining the location of faults. It was tested and compared to the discrete wavelet transform (DWT) for various fault conditions. Based on the simulation results, the proposed method was found to have a slightly higher success rate than DWT, in general. Moreover, it can work with low sampling frequencies, and it provides a better resolution than DWT to display the traveling waves in noise conditions.

    • SDG 9 · Sanayi, Yenilikçilik ve Altyapı
    AtıfScopus9WoS8OpenAlex7
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  • MakaleYalnız künye2021Scopus SJRQ1
    Investigation of Some Metal Accumulation Ability of Phragmites australis from Poultry Slaughterhouse Wastewaters

    Topal, Murat

    In this study, the bioaccumulation of some metals by Phragmites australis plants exposed to poultry slaughterhouse wastewater was investigated. For this aim, Mo, As, Cd, Se, Cu, Zn, Cr, Ba, Ti, Fe, Al, and Mn metals were determined in slaughterhouse wastewaters, P. australis plants, and sediment samples. The uptake of metals by P. australis was investigated. Also, BCF and TF values were calculated and compared with reference plant values. The maximum metal accumulation in P. australis plants exposed to poultry slaughterhouse wastewaters was 5900% for Al and 33.5% for Mn when compared with reference plant values. According to the BCF values, P. australis was bioaccumulative for Mo, Se, and Al. As a result, it was determined that P. australis plant can be used in the remediation of metals found in poultry slaughterhouse wastewaters and would be a good accumulator.

    • SDG 2 · Açlığa Son
    • SDG 6 · Temiz Su ve Sanitasyon
    • SDG 12 · Sorumlu Üretim ve Tüketim
    • SDG 15 · Karasal Yaşam
    AtıfScopus2WoS1OpenAlex4
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  • Kitap BölümüYalnız künye2021
    Fine–kinney-based occupational risk assessment using interval-valued pythagorean fuzzy vikor

    Gul, Muhammet; Mete, Suleyman; Serin, Faruk; Celik, Erkan

    This chapter aims at the adaptation of the Fine–Kinney occupational risk assessment concept into the VIKOR multi-attribute decision-making method with an interval-valued Pythagorean fuzzy set. The classical fuzzy set theory has been improved by proposing a number of extended versions. One of them is the Pythagorean fuzzy set. It has been firstly developed by Yager (IEEE Transactions on Fuzzy Systems 22:958–965, [1]). In this chapter, we use this type of fuzzy set with VIKOR since it reflects uncertainty in occupational risk assessment and decision-making better than other fuzzy extensions. To demonstrate the proposed approach applicability, a case study regarding the activities of the surface treatment area in a chrome plating unit of a gun factory is performed. Some additional analysis to test the solidity and validity of the approach is executed. Finally, the Python codes in the implementation of the proposed approach are given for scholars and practitioners for usage in further studies.

    AtıfScopus14OpenAlex5
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  • EditoryalYalnız künye2021
    Preface

    Gul, Muhammet; Mete, Suleyman; Serin, Faruk; Celik, Erkan

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  • MakaleYalnız künye2021Scopus SJRQ1
    Evaluation of the efficiency of chlorpyrifos-ethyl remediation by Methylobacterium radiotolerans and Microbacterium arthrosphaerae using response of some biochemical biomarkers

    Onder Erguven, Gokhan; Tatar, Şule; Serdar, Osman; Yildirim, Nuran Cikcikoglu

    This study reveals out detoxifying and antioxidant enzyme response of Gammarus pulex exposed/polluted to chlorpyrifos-ethyl insecticide before and after biodegradation/bioremediation by Methylobacterium radiotolerans and Microbacterium arthrosphaerae. Cytochrome P450 1A1, glutathione S-transferase, catalase, and superoxide dismutase activities in G. pulex exposed to chlorpyrifos-ethyl before and after bioremediation/biodegradation by these two bacteria during 24 and 96 h tested by using commercial ELISA kits. The activity of catalase enzyme was decreased depending on chlorpyrifos-ethyl before and after bioremediation/biodegradation the enzyme activity was increased repeatedly. Superoxide dismutase activity level increased after chlorpyrifos-ethyl exposure in 96 h (p > 0.05). Following bioremediation, superoxide dismutase enzyme activity decreased again during 24 h (p > 0.05) and increased during 96 h (p < 0.05). Statistical differences were not found in cytochrome P450 1A1 enzyme activity before and after the process (p > 0.05). No significant differences were determined during the activity of glutathione S-transferase in 24 h (p > 0.05). The activities of glutathione S-transferase were increased after exposure of chlorpyrifos-ethyl during 96 h. After bioremediation; the activity of glutathione S-transferase increased even more (p < 0.05). The results determined that activities of G. pulex at superoxide dismutase, catalase, and glutathione S-transferase are common biomarkers for revealing out the efficiency of bioremediation of chlorpyrifos-ethyl with these two types of soil bacteria. [Figure not available: see fulltext.]

    • SDG 6 · Temiz Su ve Sanitasyon
    AtıfScopus15WoS14OpenAlex16
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  • Kitap BölümüYalnız künye2021
    Fine–kinney-based occupational risk assessment using interval type-2 fuzzy vikor

    Gul, Muhammet; Mete, Suleyman; Serin, Faruk; Celik, Erkan

    In this chapter, we improved Fine–Kinney occupational risk assessment approach with interval type-2 fuzzy VIKOR (IT2FVIKOR). VIKOR is a compromise multi-attribute decision-making method proposed by Opricovic (1998). Similar to other compromised solution-based approaches, it considers the solution which is closest to the ideal. In this chapter, we adapted the interval type-2 fuzzy sets (IT2FSs) into VIKOR as it reflects the uncertainty well in decision-making. IT2FVIKOR algorithm under the Fine–Kinney concept provides a useful and solid approach to the occupational health and safety risk assessment. In addition to proposing this new approach, a case study is performed in a gun and rifle barrel external surface oxidation and coloring unit of a gun factory. A validation and a sensitivity analysis is also attached to this study. Finally, the proposed approach is implemented in Python.

    AtıfScopus4OpenAlex5
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  • MakaleYalnız künye2021Scopus SJRQ1
    Assessment of Seismic Behavior Factor of Code-Designed Steel–Concrete Composite Buildings

    Etli, Serkan; Güneyisi, Esra Mete

    In this study, the seismic behavior factor of steel–concrete composite buildings was examined. For this purpose, 5-, 10-, 15- and 20-story composite moment-resisting frame (CMRF) buildings having concrete-filled steel tube columns and composite beams were designed at medium ductility (DCM) and high ductility (DCH) levels as per the regulations of Eurocode 8. Examined DCM structures were designed for a PGA of 0.2 g while DCH structures were designed for a PGA of 0.4 g. SeismoStruct software was utilized in the design and performance assessment of the case study structures. Nonlinear static pushover and incremental dynamic analyses were used. In the pushover analysis, the uniform and triangular load distributions were adopted while 12 earthquake ground motions were employed in the dynamic analysis. The effect of ductility levels and number of stories on the seismic behavior of CMRFs was studied using the results of the nonlinear analysis. To this, the variation in the lateral response, global yielding value, code-based behavior factor and component, and dynamic behavior factor were presented for CMRF structures with DCM and DCH. It was observed that the behavior factor of all CMRFs exhibited well above the design assumptions, especially DCM class CMRFs.

    • SDG 9 · Sanayi, Yenilikçilik ve Altyapı
    • SDG 11 · Sürdürülebilir Şehirler ve Topluluklar
    AtıfScopus16WoS11OpenAlex34
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  • MakaleYalnız künye2021Scopus SJRQ2
    Determination of Optimum Process Conditions by Central Composite Design Method and Examination of Leaching Kinetics of Smithsonite Ore Using Nitric Acid Solution

    Tanaydın, Mehmet Kayra; Bakıcı Tanaydın, Zümra; Demirkıran, Nizamettin

    The leaching behavior of Tunceli smithsonite ore in nitric acid was evaluated in two study steps including optimization of leaching process and kinetics modeling. The individual and synergistic effects of effective parameters such as nitric acid concentration, solid-to-liquid ratio, stirring speed, and temperature on the dissolution rate of zinc were investigated using central composite design. Four factors including temperature (30–50 °C), nitric acid concentration (0.2–0.5 mol/L), stirring speed (350–600 rpm), and solid-to-liquid ratio (0.004–0.01 g/L) were investigated. The dissolution percent of zinc (97%) was obtained in 120 min of leaching time: acid concentration 0.5 mol/L, temperature 50 °C, stirring speed 500 rpm, and solid–liquid ratio 2/500 g/mL at the optimum conditions obtained using the central composite design. The dissolution kinetics of smithsonite was examined according to heterogenous models and it was found that the dissolution rate was controlled by ash layer diffusion process. It was found that the leaching rate increased with increasing temperature, stirring speed, and acid concentration as well as decrescent particle size and solid/liquid ratio. The trial data were analyzed by statistical and graphical methods and the activation energy of this leaching process was determined to be 28.63 kJ·mol−1. Graphical Abstract: [Figure not available: see fulltext.].

    AtıfScopus9WoS9OpenAlex10
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  • Kitap BölümüYalnız künye2021
    Fine–kinney-based occupational risk assessment using fuzzy best and worst method (f-bwm) and fuzzy mairca

    Gul, Muhammet; Mete, Suleyman; Serin, Faruk; Celik, Erkan

    The best-worst method (BWM) proposed by Rezaei (Omega 53:49–57, [1]) is an MCDM method used to achieve the weights of the criteria by making fewer pairwise comparisons and using more consistent decision matrices. In this chapter, instead of crisp numbers, triangular fuzzy numbers that reflect the uncertainty well in real-world problems are used in integration with the BWM method (Guo and Zhao in Knowl Based Syst 121:23–31, [2]) in determining factor weights. Using the fuzzy best and worst method (F-BWM), a model based on Fine–Kinney occupational health and safety risk assessment method was developed for the first time in the literature. Three parameters of Fine–Kinney method are weighted by the mathematical models of F-BWM. Then, the risks are prioritized by fuzzy multi-attribute ideal real comparative analysis (F-MAIRCA). A case study was conducted to demonstrate the feasibility of the approach, and besides this case study, a comparative study was also conducted to test the validity of the proposed approach. This approach led to the conclusion that Fine–Kinney’s method, BWM, MAIRCA, and triangular fuzzy sets make the risk decision-making process more dynamic, taking into account the benefits of these methods individually or in integration.

    AtıfScopus11OpenAlex12
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  • MakaleYalnız künye2021Scopus SJRQ2
    Recovery of Cu(II) by Acorga M5640 After Leaching of Malachite Ore in Perchloric Acid Solutions

    Demirkıran, Nizamettin; Tanaydın, Mehmet Kayra

    Abstract: In the present study, the recovery of Cu2+ from the resulting actual leach solution after the leaching of malachite ore in perchloric acid solutions was examined by applying the solvent extraction method. The organic phase was prepared using Acorga M5640 and kerosene. The effects of the initial pH of solution, extractant concentration, Cu2+ concentration, temperature, and stirring speed on the extraction process were investigated. It was determined that the extraction yield increased with an increase in the extractant concentration, initial pH of aqueous solution, stirring speed, and temperature, and with a decrease in the concentration of Cu2+. To prevent or minimize Zn2+ transfer to the organic phase and to ensure maximum Cu2+ extraction from the aqueous phase, the optimal values for the initial pH of the aqueous phase, initial concentration of Cu2+, extractant concentration, temperature, and stirring speed were selected to be 1, 0.152 g/L, 4% (v/v), 25 °C, and 400 rpm, respectively. The stoichiometry and mechanism of the extraction process were determined applying the equilibrium slope method. The changes in the Gibbs free energy, enthalpy, and entropy were determined. The changes in these thermodynamic parameters were calculated to be − 3.87 kJ/mol, 64.67 kJ/mol, and 0.23 kJ/(mol K), respectively. Graphical Abstract: The extraction percentage of Cu2+ increases substantially when the initial pH of the leach solution increases from 0.1 to 1. The further increase in the initial pH above 1 does not create an increase in the extraction extent of Cu2+. When the initial pH of the leach solution is higher than 1, the amount of Zn2+ transferred from the aqueous phase to the organic phase increases significantly.[Figure not available: see fulltext.].

    • SDG 12 · Sorumlu Üretim ve Tüketim
    AtıfScopus7WoS5OpenAlex9
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  • Kitap BölümüYalnız künye2021
    Fine–kinney-based occupational risk assessment using hexagonal fuzzy multimoora

    Gul, Muhammet; Mete, Suleyman; Serin, Faruk; Celik, Erkan

    Hexagonal fuzzy numbers (HFNs) can be used as a proficient logic to simplify understanding of ambiguity information. HFNs present the usual information in a comprehensive way and also the ambiguity section can be exemplified in a reasonable way. In this chapter, we proposed an improved Fine–Kinney occupational risk assessment approach using a well-known MCDM method Multi-Objective Optimization by Ratio Analysis (MULTIMOORA) using hexagonal fuzzy numbers. Since the mere MULTIMOORA has failed to handle uncertainty and vague information which usually exist in real world problems, we follow integration of HFNs and MULTIMOORA (HFMULTIMOORA). To show the applicability of the novel approach, a case study of risk assessment of a raw mill in cement plant was provided. Comparative analysis with using two aggregation tools as reciprocal rank method and dominance theory are carried out. Finally, the Python implementation of the proposed approach is implemented to be effective for those concerned in the future.

    AtıfScopus7OpenAlex5
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  • MakaleAçık Erişim2021Scopus SJRQ3
    On complex Sasakian manifolds

    Turgut Vanlı, Aysel; Ünal, İnan; Avcu, Keziban

    In this article, we study a class of normal complex contact metric manifold called a complex Sasakian manifolds. This kind of manifolds have a globally defined complex contact form and normal complex contact structure. We define a complex Sasakian manifold by considering the real case and we present general properties. Also, we obtain some useful curvature relations. Finally, we examine flatness conditions for general curvature tensor B.

    AtıfScopus3OpenAlex2
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  • MakaleAçık Erişim2021Scopus SJRQ1
    An integrated interval type 2 fuzzy AHP and COPRAS-G methodologies for supplier selection in the era of Industry 4.0

    Kayapinar Kaya, Sema; Aycin, Ejder

    Supply chain has a very extensive and dynamic structure that incorporates new business models, new customer expectations, market searches and technological developments. With the introduction of Industry 4.0 into supply chain, a rapid and intensive process of digitalization begins to transform every step of supply chain. Supply chain selection is one of the essential decisions in reducing the supply chain cost and improving overall quality of product and services. With the implication of digital technologies and Industry 4.0 on supply chain, the supplier selection process has been significantly changed during the recent years. Companies are willing to need new requirements for their own suppliers in accordance with Industry 4.0 implementations and technologies. This paper aims to identify key criteria to Industry 4.0 technologies and evaluate them to select the right suppliers selection in the era of Industry 4.0. Within the scope of this study attempts to develop an integrated interval type 2 fuzzy AHP and GOPRAS-G methodology to select the appropriate supplier in the face of Industry 4.0 implementations. For this purpose, interval type 2 fuzzy AHP was employed to weight the supplier evaluation criteria and then, Gray COPRAS method has been applied to prioritize suppliers. This paper is to provide practitioners and researchers with insight into how Industry 4.0 strategies influence on supplier selection.

    AtıfScopus63WoS51
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  • MakaleAçık Erişim2021Scopus SJRQ2
    Comparative Toxicity of Alpha and Gamma Iron Oxide Nanoparticles in Rainbow Trout: Histopathology, Hematology, Accumulation, and Oxidative Stress

    Gürkan, Mert; Gürkan, Selin Ertürk; Yılmaz, Sevdan; Ateş, Mehmet

    In this study, alpha and gamma iron oxide nanoparticles, characterizations, toxic effects after being exposed to rainbow trout (Oncorhynchus mykiss) at 0, 1, 10 and 25 mg/L concentrations for 10 days, and then 10-day recovery period without any nanoparticle exposure were examined for histopathological (kidney, liver and gill), hematological, iron accumulation and potential for oxidative stress (TBARS and GSH). Histopathological damages significant at the exposure of increasing concentrations of both nanoparticles (increase in melanomacrophage aggregations, epithelial tissue deformations, cytoplasmic vacuolizations, fatty changes, necrosis, pyknosis, hyperplasia, hypertrophy, lamellar fusions, capillary dilatations). Gamma nanoparticles were determined to accumulate more than the alpha nanoparticles. The most Fe accumulation was detected in the liver. The findings of oxidative stress parameters showed that both nanoparticles have the potential to generate oxidative stress. It was concluded that the exposure of alpha and gamma nanoparticles at specified concentrations and durations had a toxic effect on rainbow trout and the toxicity of these nanoparticles was similar.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus18WoS12OpenAlex16
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  • MakaleAçık Erişim2021Scopus SJRQ1
    Ameliorative effect of Fennel (Foeniculum vulgare) essential oil on chlorpyrifos toxicity in Cyprinus carpio

    Pala, Ayşegül; Serdar, Osman; Mişe Yonar, Serpil; Yonar, Muhammet Enis

    Chlorpyrifos (CPF) is an organophosphate pesticide that is frequently and widely used to control both agricultural and domestic pests worldwide. In this study, the protective effect of Fennel (Foeniculum vulgare) essential oil (FEO) was investigated in carp (Cyprinus carpio) exposed to CPF. The fish were divided into six groups that one control group (no treatment) and five experimental groups (FEO (3ml/100g diet) group, CPF1 (0.023 mg/l) group CPF2 (0.046 mg/l) group, CPF1 (0.023 mg/l) plus FEO (3ml/100g diet) group, CPF2 (0.046 mg/l) plus FEO (3ml/100g diet) group). Blood and tissue (liver, kidney, gill, and brain) samples were taken from the fish at the end of 14 days of application. Hemoglobin (Hb) level, nitoblue tetrazolium (NBT) activity, and total immunoglobulin (TI) level were measured in blood samples of fish. Acetylcholinesterase (AChE) activity was determined in brain tissue while malondialdehyde (MDA) level, reduced glutathione (GSH) level, catalase (CAT), and glutathione peroxidase (GPx) activity were determined in liver, kidney, and gill tissues. The results showed that there was a significant decrease in Hb level, NBT activity, and TI levels in CPF-treated fish compared to the control group. In addition, increased in MDA levels and significant decreases in GSH level, AChE, CAT, and GPx activities were observed in CPF-treated groups. However, FEO-treated was showed a significant improvement in all parameters except AChE activity compared to CPF groups. These study findings showed that FEO could improve CPF-induced toxicity in C. carpio, except inhibition of AChE activity.

    • SDG 2 · Açlığa Son
    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus6WoS6OpenAlex8
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  • MakaleAçık Erişim2021Scopus SJRQ2
    Effects of Aging on Magnetic and Thermal Characteristics of NiMnCoSn Magnetic Shape Memory Alloys

    Kök, Mediha; Aydoğdu, Kumruya; Kanca, M. Sait; Qader, Ibrahim Nazem; Öner, Ecem; Coşkun, Meltem

    Heusler shape memory alloys are important for many applications due to their typical magnetic and shape memory behaviors. In this study, a Ni50Mn36Sn12Co2 (at.%) alloy was manufactured by arc-melting technique, then the ingot cooled to ambient temperature in the natural atmosphere. Three different temperatures, including 500 °C (773 K), 700 °C (973 K), and 900 °C (1173 K), was selected for aging the samples cut from the main ingot. The impact of aging on the crystalline; microstructure; caloric; and magnetic properties of the alloys were investigated through x-ray diffraction (XRD); scanning electron microscope; differential scanning calorimetric (DSC), differential thermal analysis, and thermal gravimetric (TG); and physical property measuring system was investigated, respectively. The aging in different temperatures led to the shift DSC curve, such that the martensitic phase transformation temperatures of the sample aged at 773 K increased, however, the transformation at 973 and 1173 K decreased compared to the as-casted alloy. The different phase transformation behavior showed that the alloy aged at 773 K has the maximum elastic energy, enthalpy and entropy change compared to the reset of samples, on the other hand, its crystallite sized obtained from XRD analysis comparably diminished. Besides, the TG analysis revealed that the mass gain almost occurs at a temperature above 773 K, therefore the magnetization of the alloys aged at 973 and 1173 K decreased due to a thin oxide layer formed on the surface of the alloys.

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  • MakaleYalnız künye2021Scopus SJRQ2
    Failure modes and effects analysis based on neutrosophic analytic hierarchy process: method and application

    Yucesan, Melih; Gul, Muhammet

    Failure modes and effects analysis (FMEA) is a commonly used method in risk evaluation. In this paper, a novel FMEA model based on neutrosophic analytic hierarchy process (NAHP) is proposed to overcome shortcomings of the risk prioritization of classical FMEA. Neutrosophic sets approach real-world decision-making problems from a three-aspect structure (i.e., truthiness, indeterminacy and falsity). Therefore, initially, AHP is merged with neutrosophic sets to assign importance weights to risk parameters in FMEA. The encountered failure modes are then prioritized with respect to the previously weighted risk parameters. Each element in AHP comparison matrices is considered as triangular neutrosophic numbers, and score functions are used to transform NAHP elements to deterministic values. The flexibility of determining the weight to each parameter of FMEA (severity, occurrence and detection) and evaluation of each failure mode against these parameters are more well-suited to the real decision-making condition. Finally, a case study in the textile industry is provided to show the applicability of the novel model. Sensitivity and comparative analysis are also performed to validate the results.

    AtıfScopus42WoS27OpenAlex33
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  • Kitap BölümüYalnız künye2021
    Fine–kinney-based occupational risk assessment using intuitionistic fuzzy todim

    Gul, Muhammet; Mete, Suleyman; Serin, Faruk; Celik, Erkan

    This chapter applies a novel occupational risk assessment approach which merges TODIM with the Fine–Kinney method under the intuitionistic fuzzy set concept. Risk parameters of Fine–Kinney and OHS experts are weighted by an intuitionistic fuzzy weighted averaging (IFWA) aggregation operator. Hence, hazards are quantitatively evaluated and prioritized using the proposed approach. To illustrate the novel risk assessment approach, processes of the gun and rifle assembly line of a factory are handled. A comprehensive risk assessment is carried out to improve operational safety and reliability in the industry. We adapt intuitionistic fuzzy sets in the existing study since they reflect uncertainty with the aid of their membership and nonmembership functions in decision-making better than classical fuzzy extensions. An additional sensitivity analysis by changing the attenuation parameter of TODIM is performed to test the validity of the approach. Finally, the Python codes in the implementation of the proposed approach are given for scholars and practitioners for usage in further studies.

    AtıfScopus5OpenAlex9
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  • Kitap BölümüYalnız künye2021
    Fine–kinney-based occupational risk assessment using single-valued neutrosophic topsis

    Gul, Muhammet; Mete, Suleyman; Serin, Faruk; Celik, Erkan

    Neutrosophic sets are initially recommended by Smarandache (First international conference on neutrosophy, neutrosophic logic, set, probability, and statistics. University of New Mexico, Gallup, NM, pp 338–353, 2002 [1]). These sets reflect uncertainty and vagueness in real-world problems better than classical fuzzy set theory. It takes into consideration three decision-making situations called indeterminacy, truthiness, and falsity. In Zadeh traditional fuzzy set theory, there is just membership function fuzzy set degree. But, in neutrosophic environment, it considers three membership functions. Unlike intuitionistic fuzzy sets, an indeterminacy degree is considered. In this chapter, we applied a special form of neutrosophic set as single-valued neutrosophic set (SVNs) with the technique for order preference by similarity to ideal solution (TOPSIS) under the concept of Fine–Kinney occupational risk assessment. Since the mere TOPSIS has failed to handle imprecise and vague information which usually exist in real-world problems, we follow the integration of SVNs and TOPSIS. To demonstrate the applicability of the novel approach, a case study of risk assessment of a wind turbine in times of operation was provided. Comparative analysis with some similar approaches and sensitivity analysis by changing the weights of Fine–Kinney parameters are carried out. Finally, the Python implementation of the proposed approach is executed to be useful for those concerned in the future.

    AtıfScopus12OpenAlex9
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  • MakaleYalnız künye2021Scopus SJRQ1
    Toxicological effects of di-(2-ethylhexyl) phthalate in Gammarus pulex: a biochemical and histopathological assessment

    Yildirim, Nuran Cikcikoglu; Ak, Tuba Parlak; Samasas, Omer

    This study aimed to reveal the toxic characteristics of di-(2-ethylhexyl) phthalate (DEHP) by examining the biochemical and histopathological changes in Gammarus pulex, exposed to different doses of DEHP. For this purpose, the lethal concentration 50 (LC50) value of the DEHP was determined by using a static test and found to be 0.079 ± 0.01 ppm. Three subletal doses of DEHP were applied to the G. pulex for 24 and 96 h. Superoxide dismutase (SOD), catalase (CAT), cytochrome P450 1A1 (CYP1A1), and glutathione S-transferase (GST) activities were measured using commercial ELISA kits. The caspase method, which is an immunohistochemical analysis method, was used to determine the apoptosis that occurred in the G. pulex. The results showed that the CYP1A1 activities decreased in the groups exposed to different doses of DEHP compared to the control group (p > 0.05). CAT activity was found to increase in the application groups at the 24 and 96 h compared to the control group. In addition, it was found that SOD and GST activities increased at the 96 h compared to the control group. In light of the microscope examination of the model organism, hemolymphatic lacunae filled with hemolymph and reduction or absence of hemolymphatic ducts were observed especially in the G. pulex gills. Collapse of the gills and hyperplasia were observed after 96 h. As a result, it is suggested that changes in SOD, CAT, and GST activities can potentially be used as sensitive biomarkers for risk assessment in the environment and increased immunoreactivity in G. pulex caused by DEHP depending on increased application doses and application times.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus6WoS3OpenAlex5
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