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- MakaleYalnız künye2017Scopus SJRQ3Synthesis and characterization of Bioglass-based bone grafts with Gelatine substitution for biomedical applications
Aksakal, B.; Demirel, M.
Background: Syntesizing alternative bone graft materials are important in biomedical applications. Their morphology, mechanical properties and cell viability plays an important role in tissue engineering. OBJECTIVE: Bioglass (B) based bone grafts with Gelatin (G) substitution were syntesized via the sol-gel method and were compared with various Gelatin and Bioglass concentrations (wt%). METHODS: Syntesized bone grafts were characterized by Scanning Electron Microscopy (SEM) and X-ray diffraction (XRD) to show the structural and morphological changes of the fabricated B-based bone grafts. RESULTS: It was demonstrated that the concentration of pore size increased with increasing amounts of Gelatin in wt%. The biograft-B40G20 produced the highest flexture strength and hardness. Increasing the pore size caused a decrease in hardness and flexture stress of B-based biografts. CONCLUSIONS: Cell viability tests were conducted on the fabricated biografts and it was shown that the cell viability increased in fabricated B-based bone grafts.
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İncele - MakaleYalnız künye2017Scopus SJRQ1The effect of Zirconia/Yttria/Silver substitutions on mechanostructure and cell viability of the synthesized bioceramic bone grafts
Aksakal, Bunyamin; Demirel, Mehtap
Hydroxyapatite (HA) based biografts were synthesized by substitution of Zirconia (Zr), Yttria (Y2O3) and Silver (Ag) using the sol-gel method. Fabricated bone grafts (H40ZrYt and H50Yt10) were compared with a control biograft. The effects of Zr and Y2O3 and Ag additions on the morphological, mechanical and cell viability of the synthesized biografts were analyzed. The biografts were characterized by X-ray Diffractometer (XRD) and Scanning Electron Microscope (SEM). All biografts were then embedded into the drilled holes (D=3.2 mm) in rabbit femurs. The rabbits were then sacrificed after twelve weeks. Three-point bending (3-PB) tests were conducted on defected and grafted regions. Flexural strength values were found to be 347, 149 and 180 MPa, for the H40ZrYt, H50Yt10 and the control/commercial graft, respectively. Cell viability results indicated that the percentage viability ratios slightly increased after the substitution of Ag into the H50Yt10 biograft at 0.1 and 0.3 µg/ml concentrations and into the H40ZrYt biograft at a 0.1 µg/ml concentration. Although the cell viability was a bit lower in the H50Yt10 graft, the H40ZrYt graft achieved better results compared to the counterpart grafts. Furthermore, the hardness of both of the novel fabricated grafts were found to be higher than the control/commercial graft, however, as the flexture strength of H40ZrYt was higher but H50Yt10 was lower than the control/commercial graft.
AtıfScopus11WoS10OpenAlex13İncele - MakaleYalnız künye2017Scopus SJRQ2The effect and characterization of newly synthesized SrBr2 reinforced bone grafts on structure and cell viability
Demirel, Mehtap; Aksakal, Bünyamin; Kaya, Ali İhsan
Abstract: In this study, a highly durable SrBr2 compound was added to Ca(NO3)2·4H2O, KOH, NaNO3, P2O5, and urea (CO(NH2)2) compounds at different ratios (wt 10–30%); biografts were synthesized in different compositions using the sol gel method They were characterized using X-ray diffraction, Fourier transform infrared spectrometer, scanning electron microscope, and mechanical tests e.g. hardness and compression. Structural, mechanical properties and cell viabilities of the synthesized biografts were comparatively examined. Fourier transform infrared spectrometer and X-ray diffraction analysis results showed that, including SrBr2, hydroxyapatite had formed in the biografts. Also, hardness and compression tests revealed that compressive stress and hardness values of the grafts increased as the amount of SrBr2 increased. The cell viability ratios also enhanced with the amount of SrBr2 increased in the synthesized biografts. Graphical Abstract: [InlineMediaObject not available: see fulltext.]
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