Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Karaaslan Ayhan, Nagihan(2)
- Karaaslan, Nagihan M.(2)
- Yaman, Mehmet(2)
- Angeloni, Simone(1)
- Ates, Burhan(1)
- Aydin, Çağlar Mert(1)
- Aydın, Çağlar Mert(1)
- Ayhan, Nagihan Karaaslan(1)
- Barroso, Joaquim Jose(1)
- Buldu, Gul(1)
- Cakilcioglu, Ugur(1)
- Caprioli, Giovanni(1)
- Goksin Karaaslan, Merve(1)
- Goksu, Ali(1)
- Guler, Osman(1)
- Hasar, Ugur Cem(1)
- Hayaloğlu, Ali Adnan(1)
- Ince, Muharrem(1)
- Kaplan Ince, Olcay(1)
- Kaplan, Alevcan(1)
- Kaplan, Olcay(1)
- Karaaslan Tunc, Merve Goksin(1)
- Kaya, Gokce(1)
- Kurt-Celep, İnci(1)
- Kurucay, Ali(1)
- Mahomoodally, Mohamad F.(1)
- Mustafa, Ahmed M.(1)
- Noma, Samir Abbas Ali(1)
- Rosenberg, Erwin(1)
- Sabanci, Serdal(1)
- Sharmeen, Jugreet(1)
- Uba, Abdullahi I.(1)
- Zengin, Gokhan(1)
- Çelikbıçak, Ömür(1)
- Çilingir, Seda(1)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ2Ultrasound assisted extraction of phenolic compounds from Tunceli walnut varieties using deep eutectic solvents
Aydin, Çağlar Mert
This study aimed to improve a green way to enhance extraction of bioactive compounds from walnut, and to evaluate the effect of altitude on walnut bioactive content. Total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity were evaluated as bioactive compounds of walnut. In comparison with conventional solvents (water, ethanol and methanol), three DESs (Deep eutectic solvents) were formed from choline chloride, zinc chloride, and sorbitol as HBA and ethylene glycerol as HBD. The DESs (DES-1 and DES-2) generated from choline chloride and zinc chloride exhibited better extraction efficiencies for any bioactive compound than that of conventional solvents. Especially, the DES formed from the choline chloride: ethylene glycerol demonstrated the highest extraction efficiency. However, sugar-based DES showed the worst extraction efficiency. The altitude significantly affected extracted bioactive contents from walnuts (Hozat 1000m, Ovacik 1300m and Nazimiye 1550m). Walnut’s extracted bioactive content ordinarily decreased as the altitude increased, regardless of solvent type used in extraction. The result is a light to enhancing knowledge as to DES usage and its extraction efficiency of bioactive compounds for food applications. In addition, it gives better understanding of altitude effect on the content of bioactive compounds in walnuts.
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İncele - MakaleAçık Erişim2024Scopus SJRQ1Evaluation of antioxidant, antimicrobial, and bioactive properties and peptide sequence composition of Malatya apricot kernels
Aydın, Çağlar Mert; Çelikbıçak, Ömür; Hayaloğlu, Ali Adnan
BACKGROUND: This study used four different apricot (Prunus armeniaca) kernels cultivated in Malatya during two consecutive years. The varieties were Hacihaliloglu, Hasanbey, Kabaasi, and Zerdali. The physicochemical properties of the kernels were determined, and the bioactive content of the kernels was evaluated using kernel hydrolysates prepared using trypsin. RESULTS: With regard to the physicochemical properties of the kernels, the dry matter ratio and protein content were the highest in the Hacihaliloglu variety; the ash ratio was the highest in the Kabaasi variety, and the free oil ratio was the highest in the Hasanbey variety. The bioactive compound content changed according to kernel variety. Angiotensin-converting enzyme inhibitors activity was found to be the highest in the Hacihaliloglu and Hasanbey varieties, which had the lowest amygdalin content, and Zerdali had the highest amygdalin content. The antioxidant and antimicrobial effects of the kernels varied, with Hasanbey and Kabaasi generally having the highest content in both analyses. Moreover, a concentration of 20 mg mL−1 of the hydrolysate was determined to have a destructive effect for the microorganisms used in this study. The storage protein of the kernels, except Hacihaliloglu, was found to be Prunin 1, with the longest matching protein chain in the kernels being R.QQQGGQLMANGLEETFCSLRLK.E. CONCLUSION: The results suggest that the peptide sequences identified in the kernels could have antihypertensive, antioxidative, and Dipeptidyl peptidase IV (DPP-IV) inhibitory effects. Consequently, apricot kernels show potential for use in the production of functional food products. Of the kernels evaluated in this study, Hacihaliloglu and Hasanbey were deemed the most suitable varieties due to their higher bioactive content and lower amygdalin content.
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İncele - MakaleAçık Erişim2023Scopus SJRQ2Unraveling the chemical profile, antioxidant, enzyme inhibitory, cytotoxic potential of different extracts from Astragalus caraganae
Kurt-Celep, İnci; Zengin, Gokhan; Uba, Abdullahi I.; Caprioli, Giovanni; Mustafa, Ahmed M.; Angeloni, Simone; Cakilcioglu, Ugur; Guler, Osman; Kaplan, Alevcan; Sharmeen, Jugreet
Six extracts (water, ethanol, ethanol-water, ethyl acetate, dichloromethane, and n-hexane) of Astragalus caraganae were studied for their biological activities and bioactive contents. Based on high-performance liquid chromatography-mass spectrometry (HPLC-MS), the ethanol-water extract yielded the highest total bioactive content (4242.90 µg g−1), followed by the ethanol and water extracts (3721.24 and 3661.37 µg g−1, respectively), while the least total bioactive content was yielded by the hexane extract, followed by the dichloromethane and ethyl acetate extracts (47.44, 274.68, and 688.89 µg g−1, respectively). Rutin, p-coumaric, chlorogenic, isoquercitrin, and delphindin-3,5-diglucoside were among the major components. Unlike the dichloromethane extracts, all the other extracts showed radical scavenging ability in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay (8.73–52.11 mg Trolox equivalent [TE]/g), while all extracts displayed scavenging property in the 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging assay (16.18–282.74 mg TE/g). The extracts showed antiacetylcholinesterase (1.27–2.73 mg galantamine equivalent [GALAE]/g), antibutyrylcholinesterase (0.20–5.57 mg GALAE/g) and antityrosinase (9.37–63.56 mg kojic acid equivalent [KAE]/g) effects. The molecular mechanism of the H2O2-induced oxidative stress pathway was aimed to be elucidated by applying ethanol, ethanol/water and water extracts at 200 µg/mL concentration to human dermal cells (HDFs). A. caraganae in HDF cells had neither a cytotoxic nor genotoxic effect but could have a cytostatic effect in increasing concentrations. The findings have allowed a better insight into the pharmacological potential of the plant, with respect to their chemical entities and bioactive contents, as well as extraction solvents and their polarity.
AtıfScopus31OpenAlex36İncele - MakaleYalnız künye2022Scopus SJRQ3Characterization of the antioxidant activity, total phenolic content, enzyme inhibition, and anticancer properties of Achillea millefolium L. (yarrow)
Karaaslan Ayhan, Nagihan; Karaaslan Tunc, Merve Goksin; Noma, Samir Abbas Ali; Kurucay, Ali; Ates, Burhan
The antioxidant activity, total phenolic content, enzyme inhibition, anticancer properties of Achillea millefolium L. (yarrow), which is generally consumed by humans as herbal tea, were investigated. Yarrow extracts were prepared with different extraction techniques and solvents and the optimum conditions were determined. When the antioxidant activity and total phenolic content results were evaluated, the best yield was obtained with ultrasound-assisted extraction for all solvents. Moreover, the yields from highest to lowest were methanol, water, and acetonitrile. The enzyme inhibition and anticancer of Achillea millefolium L. extracts using methanol were evaluated. The IC50 values for the inhibition of xanthine oxidase and acetylcholinesterase were 4.974 ± 0.54 and 21.891 ± 1.118 µg/mL, respectively. The extract concentration was determined to be 23.85 μg/mL for 50% reduction in growth inhibitory activity cell viability (IC50) against breast cancer (MCF-7).
AtıfScopus7OpenAlex9İncele - MakaleYalnız künye2021Scopus SJRQ1Production of Pectin from Lemon Peel Powder Using Ohmic Heating-Assisted Extraction Process
Çilingir, Seda; Goksu, Ali; Sabanci, Serdal
The ohmic heating process is known as homogeneous, efficient, and rapid heating. In the present study, it was aimed to analyze the extraction of pectin from lemon peel using ohmic heating, to evaluate the specific pectin production coefficient (SPPC, mg/kJ) and compared it with traditional pectin production (TPP). The extraction process was carried out at 3 different temperatures (70–90 °C), 3 different solid:liquid ratios (1:30, 1:40, 1:50 g/ml), 3 different extraction holding times (0–30 min), and a constant pH (pH 2 that adjusted with citric acid). From the results, extraction conditions affected the pectin yield. As the temperature and extraction holding time increased, the pectin yields increased. In general, the 30-min pectin yields of the ohmic heating-assisted extraction (OHAE) process were similar to the pectin yields obtained from the TPP under the same conditions. Performance evaluation of pectin production was made for 90 °C, and energy efficiency was found to be over 69% for 3 different solid to liquid ratios. It has been stated that as an alternative to the TPP method, the OHAE process can be applied.
AtıfScopus50WoS44OpenAlex53İncele - MakaleYalnız künye2021Scopus SJRQ1Development of comprehensive liquid chromatography with diode array and mass spectrometric detection for the characterization of (poly-)phenolic and flavonoid compounds and application to asparagus
Karaaslan Ayhan, Nagihan; Rosenberg, Erwin
The main objective of the present work was to develop a method for the simultaneous and comprehensive analysis of (poly-)phenolic and flavonoid compounds with liquid chromatography with diode array and mass spectrometric detection and its application to green asparagus samples. To this end, a representative set of polyphenols was used to develop the method. A through method validation was carried out with these. The method was applied to asparagus samples known as a healthy vegetable being rich in bioactive compounds. Polyphenol contents of asparagus samples were determined by carrying out quantitative and qualitative analyses by LC-DAD-ESI/MS. In this context asparagus sample extracts were obtained using solvents of different polarity. The results were evaluated statistically and showed that rutin is the major phenolic compound in asparagus. This demonstrates the versatility of this rapid and sensitive method for the simultaneous analysis of (poly-)phenolic and flavonoid compounds which was successfully applied to asparagus samples.
AtıfScopus15WoS15OpenAlex17İncele - MakaleYayıncıda açık erişim2020Scopus SJRQ4Assessment of elemental content, antioxidant activity, and total phenolic content of vitis sylvestris gmelin
Ayhan, Nagihan Karaaslan
In this study, we determined the Cu, Fe, Mn, and Zn contents of Vitis sylvestris Gmelin using flame atomic absorption spectrometry (FAAS), and examined the antioxidant properties of Vitis sylvestris Gmelin using radical scavenging capacities and total phenolic content tests. We found the average elemental contents; Cu, Fe, Mn, and Zn as 1.506 ± 0.042 mg/kg, 0.796 ± 0.020 mg/kg, 2.333 ± 0.033 mg/kg, and 3.191 ± 0.262 mg/kg, respectively. When we examined the antioxidant activity tests applied to different extracts, we determined the highest extraction yield with the methanol extract. DPPH radical scavenging activity, ABTS radical scavenging activity, and total phenolic content values in methanol extract were determined to be respectively 3.957 ± 0.146 mg TEAC/g fw, 9.062 ± 0.273 mg TEAC/g fw, and 2.365 ± 0.028 mg GAE/g fw. When we evaluated the antioxidant activity and total phenolic content results for all extracts statistically, we determined that there was generally a statistically significant difference between each extract (p < 0.01). Vitis sylvestris Gmelin has high antioxidant content when considering the data obtained. Also, we determined that it is an effective candidate in the protection against reactive oxygen species.
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İncele - MakaleYalnız künye2019Scopus SJRQ3Determination of antioxidant capacity using different acidified solvents and element contents of Allium tuncelianum: A regional and varietal study on endemic edible garlic
Karaaslan, Nagihan M.; Ince, Muharrem; Kaplan Ince, Olcay; Goksin Karaaslan, Merve
Allium tuncelianum (Tunceli garlic), an endemic and threatened plant species in the Tunceli province of Eastern Turkey, is an important native source for local people. The antioxidant activities of the acidified extracts of water, acetonitrile, methanol, and ethanol of Allium tuncelianum were investigated using five antioxidant capacity tests. The results indicated that methanol extract efficiencies of garlic samples using the ABTS, CUPRAC, and reducing power capacities were higher than the other extracts. Water extract and acetonitrile extract values were highest for total phenolic content and metal chelating activities, respectively. Moreover, the element contents such as calcium (Ca), copper (Cu), iron (Fe), potassium (K), magnesium (Mg), manganese (Mn), sodium (Na), and zinc (Zn) of Allium tuncelianum samples digested by microwave and ashing ovens were determined by flame atomic absorption spectrophotometry and the results were compared statistically. The Ca, Cu, K, Mg, and Zn concentrations using the microwave method were found to be higher than the ashing procedure. However, the Fe, Mn, and Na concentrations using the ashing method were found to be higher than those using the the microwave protocol.
AtıfScopus7WoS6OpenAlex7İncele - MakaleAçık Erişim2018Scopus SJRQ2Anthocyanin profile of strawberry fruit as affected by extraction conditions
Karaaslan, Nagihan M.; Yaman, Mehmet
The purpose of the study was to investigate the effect of extraction conditions to determine anthocyanin compounds in strawberry fruit. Anthocyanin profile of this fruit were determined via high-performance liquid chromatography-electrospray ionization-mass spectrometry. Flow rate of mobile phase, fragmentor potential, injection volume, and column temperature were applied to be optimum values as 0.5 mL min−1, 110 V, 5 µL, and 30°C, respectively. The extraction process was the important step in the isolation and identification of anthocyanins. For this purpose, anthocyanin contents in strawberry fruit were examined in terms of solvent type, extraction time, and liquid:solid ratio (v:w). The best extraction conditions in this fruit were found to be methanol as solvent, 30 min as extraction time and 1:1 as liquid:solid ratio (v:w). The results showed that the anthocyanin contents of strawberry fruit change by altering extraction conditions.
AtıfScopus50WoS39OpenAlex48İncele - BildiriYalnız künye2017Retrieval of electromagnetic properties of metamaterials with weak-coupling
Hasar, Ugur Cem; Buldu, Gul; Barroso, Joaquim Jose
Metamaterials (MMs) are engineered material with electromagnetic properties not commonly seen by natural materials such as negative refraction and near-zero permittivity. These materials have interesting applications ranging from perfect lens and electromagnetic cloaks to leaky-wave antennas and shifters. For such applications, electromagnetic properties of MMs are needed to be known. In this study, we propose a waveguide method for accurate electromagnetic parameter retrieval of weakly-coupled MM slabs (the wavevector is normal to the plane of the metallic inclusions). To achieve our goal, new expressions for effective permittivity and permeability as well as the magnetoelectric coupling coefficient are derived. For validation of our waveguide method, we used the simulated scattering parameters of a MM slab composed of split-ring-resonator unit cells by using a commercial 3D electromagnetic simulation program.
AtıfScopus1OpenAlex3İncele - MakaleAçık Erişim2011Scopus SJRQ2Sequential and Selective Extraction of Copper in Different Soil Phases and Plant Parts from Former Industrialized Area
Kaplan, Olcay; Kaya, Gokce; Yaman, Mehmet
Copper (Cu) is an essential trace element for all living organisms; however, excess amounts in soil, plants, and food have negative impacts on the environment and human health. The aim of this study was to determine Cu levels in different chemical phases of soils and the relationship between Cu levels in soil phases and concentrations in plants. Soils and plants grown in these soils from an industrialized area in Turkey were analyzed using a selective and four-stage sequential extraction procedure. Copper levels in exchangeable fractions were found up to 658 mg kg(-1) while total levels were in the range of 133-5609 mg kg(-1). Copper concentrations in plant parts (roots and stem) were in the range of 2.6-240 mg kg(-1). The exchangeable forms of Cu were in the range of 3-22% of total Cu concentrations. The relationships were observed between soil Cu and Rumex plant Cu, and soil Cu and root of Brassicasea plant Cu.
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