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The use of Gammarus pulex as a model organism for ecotoxicological assessment of ibuprofen and propranolol at environmental relevant concentrations

MakaleYalnız künyeScopus SJRQ2
  • SDG 3 · Sağlık ve Kaliteli Yaşam

Özet

The aim of this study is to assess the toxicity of ibuprofen (IBU) and propranolol (PRO) drugs usingGammarus pulex as a model organism. Firstly, the 96 h LC50 values of IBU and PRO were determined and then three sublethal concentrations of the drugs were exposed to G. pulex. The activities of superoxide dismutase (SOD), catalase (CAT) and acetylcholinesterase (AChE) were evaluated. SOD activity decreased in G. pulex exposed to IBU and PRO compared to control. In all groups exposed to IBU, CAT activity increased at different concentrations at 24 and 96 h. In the groups exposed to different PRO concentrations, CAT activities increased after 24 h compared to the control group (p < 0.05). AChE activities increased in all application groups exposed to IBU for 96 hours (p < 0.05). In conclusion, exposure to IBU and PRO resulted in increased oxidative damage. PRO has been found to cause neurotoxicity.

Anahtar Kelimeler

biomarkersgammarus pulexIbuprofenpropranolol
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7
WoS
5
OpenAlex
7
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Tam Kayıt
AlanDeğerDil
dc.contributor.authorCikcikoglu Yildirim, Nuran
dc.contributor.authorSerdar, Osman
dc.contributor.authorBasaran, Senay
dc.date.accessioned2026-10-28T14:55:41.655569076Z
dc.date.available2026-10-28T14:55:41.655569076Z
dc.date.issued2022
dc.description.abstractThe aim of this study is to assess the toxicity of ibuprofen (IBU) and propranolol (PRO) drugs usingGammarus pulex as a model organism. Firstly, the 96 h LC50 values of IBU and PRO were determined and then three sublethal concentrations of the drugs were exposed to G. pulex. The activities of superoxide dismutase (SOD), catalase (CAT) and acetylcholinesterase (AChE) were evaluated. SOD activity decreased in G. pulex exposed to IBU and PRO compared to control. In all groups exposed to IBU, CAT activity increased at different concentrations at 24 and 96 h. In the groups exposed to different PRO concentrations, CAT activities increased after 24 h compared to the control group (p < 0.05). AChE activities increased in all application groups exposed to IBU for 96 hours (p < 0.05). In conclusion, exposure to IBU and PRO resulted in increased oxidative damage. PRO has been found to cause neurotoxicity.
dc.description.sponsorshipMunzur University, (YLMUB018-18)
dc.description.sponsorshipMunzur Üniversitesi, MU
dc.identifier.doi10.1080/09603123.2021.1967888
dc.identifier.eissn1369-1619
dc.identifier.endpage2395
dc.identifier.issn0960-3123
dc.identifier.issue11
dc.identifier.pmid34404301
dc.identifier.scopus2-s2.0-85113166293
dc.identifier.startpage2385
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/munzur/2688
dc.identifier.volume32
dc.identifier.wosWOS:000685973400001
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofInternational Journal of Environmental Health Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbiomarkers
dc.subjectgammarus pulex
dc.subjectIbuprofen
dc.subjectpropranolol
dc.subject.classificationEnvironmental Sciences
dc.subject.classificationPublic, Environmental & Occupational Health
dc.subject.classificationEnvironmental Sciences & Ecology
dc.subject.otherAcetylcholinesterase
dc.subject.otherAmphipoda
dc.subject.otherAnimals
dc.subject.otherAntioxidants
dc.subject.otherCatalase
dc.subject.otherIbuprofen
dc.subject.otherPropranolol
dc.subject.otherSuperoxide Dismutase
dc.subject.otherWater Pollutants, Chemical
dc.subject.otherantioxidant
dc.subject.otherbiomarker
dc.subject.otherecotoxicology
dc.subject.othermodel
dc.subject.othertoxicity
dc.subject.otherArticle
dc.subject.othercontrolled study
dc.subject.otherenzyme activity
dc.subject.otherGammarus pulex
dc.subject.otherLC50
dc.subject.otherneurotoxicity
dc.subject.othernonhuman
dc.subject.otheroxidative stress
dc.subject.othersublethal concentration
dc.subject.otheranimal
dc.subject.otherwater pollutant
dc.titleThe use of Gammarus pulex as a model organism for ecotoxicological assessment of ibuprofen and propranolol at environmental relevant concentrations
dc.typeArticle
rdl.citation.openalex7
rdl.citation.scopus7
rdl.citation.wos5
rdl.departmentPertek Sakine Genç Vocational School/Department of Veterinary Medicine/Laboratorian and Veterinarian Health Programme
rdl.departmentMunzur University, Fisheries Faculty, Tunceli, Turkey
rdl.departmentMunzur University, Department of Environmental Engineering, Tunceli, Turkey
rdl.oa.statusclosed
rdl.scopus.quartileQ2
rdl.sdgSDG03
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)