Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleAçık Erişim2021Scopus SJRQ2Pollen morphology of eight endemic Inula L. (Asteraceae) species in Turkey
Karlıoğlu Kılıç, Nurgül; Yılmaz Dağdeviren, Rüya; Paksoy, Mehmet Yavuz; Tuncalı Yaman, Tutku
The pollen morphology of eight endemic species of the genus Inula L. (Asteraceae)–I. helenium subsp. orgyalis (Boiss.) Grierson, I. helenium subsp. vanensis Grierson, I. macrocephala Boiss. & Kotschy ex Boiss., I. discoidea Boiss., I. sarana Boiss., I. fragilis Boiss. & Hausskn., I. anatolica Boiss. and I. sechmenii Hartvig & Strid–distributed in Turkey was studied with light microscopy and scanning electron microscopy. We found that the pollen of these Inula taxa are prolate-spheroidal in shape (except in Inula discoidea), with the polar axis ranging from 19.18 to 33.14 µm and the equatorial diameter ranging from 18.54 to 32.92 µm. The pollen grains are tricolporate and their ornamentation is echinate. The exine thickness ranges from 0.87 to 2.07 µm. As this study demonstrates, results of Principal Component Analysis are revealed that some of the pollen characters, such as spine length and width, are significant morphological characters for taxonomic discrimination of the eight endemic Inula taxa. According to cluster analysis, two main groups of examined taxa are constituted.
AtıfScopus9WoS9OpenAlex10
İncele - MakaleYalnız künye2021Scopus SJRQ3Enzyme inhibition and antioxidant functionality of eleven Inula species based on chemical components and chemometric insights
Ceylan, Ramazan; Zengin, Gokhan; Mahomoodally, Mohamad Fawzi; Sinan, Kouadio Ibrahime; Ak, Gunes; Jugreet, Sharmeen; Cakır, Oguz; Ouelbani, Rayene; Paksoy, Mehmet Yavuz; Yılmaz, Mustafa Abdullah
The members of the genus Inula have been widely used in traditional medicinal. In the present study, 11 Inula species were investigated for their phytochemical composition, antioxidant and enzyme inhibitory effects. While quinic acid was the principal compound in I. anatolica, I. britannica, I. inuloides, I. oculus-christi, I. peacockiana, I. sechmenii, I. thapsoides and I. viscidula extracts (22.43–42.02 mg/g dry extract (DE)), I. aucheriana and I. discoidea extracts contained rutin as their most abundant compound (23.28 and 79.10 mg/g extract, respectively). Interestingly, all the Inula extracts were active inhibitors of the five key clinical enzymes (acetylcholinesterase (3.56–5.13 mg galantamine equivalent (GALAE)/g), butyrylcholinesterase (1.49–7.34 mg GALAE/g), tyrosinase (112.31–122.13 mg kojic acid equivalent (KAE)/g), α-glucosidase (0.77–2.08 mmol acarbose equivalent (ACAE)/g) and α-amylase (0.73–0.90 mmol ACAE/g)). Furthermore, the extracts were observed to exhibit substantial antioxidant capacity (1,1-diphenyl-2-picrylhydrazyl (DPPH): 58.99–188.22 mg trolox equivalent (TE)/g); 2,2-azino-bis(3-ethylbenzo-thiazoline-6-sulfonic acid) (ABTS): 90.51–220.97 mg TE/g; cupric reducing antioxidant capacity (CUPRAC): 169.88–460.53 mg TE/g; ferric reducing antioxidant power (FRAP): 81.57–237.99 mg TE/g; metal chelating activity: 8.31–25.39 mg ethylenediamine tetraacetate equivalent (EDTAE)/g; phosphomolybdenum: 1.55–2.49 mmol TE/g). In conclusion, the Inula species studied herein showed promising pharmacological potentials justified by the presence of a panoply of bioactive compounds.
AtıfScopus60OpenAlex60İncele - MakaleAçık Erişim2021Scopus SJRQ2In vitro biological activity of Salvia fruticosa Mill. infusion against amyloid β-peptide-induced toxicity and inhibition of GSK-3β, CK-1δ, and BACE-1 enzymes relevant to Alzheimer's disease
Gürbüz, Perihan; Dokumacı, Alim Hüseyin; Gündüz, Miyase Gözde; Perez, Concepcion; Göger, Fatih; Paksoy, Mehmet Yavuz; Yerer, Mükerrem Betül; Ömür Demirezer, L.
Salvia species have been traditionally used to improve cognition and have been proved to be a potential natural treatment for Alzheimer's disease. Salvia fruticosa Mill. (Turkish sage or Greek sage) demonstrated to have anticholinergic effects in vitro. The aim of this study was to understand the mechanism underlying the neuroprotective effects of S. fruticosa infusion and its representative compound rosmarinic acid, which was detected by LC-DAD-ESI-MS/MS. The protective effects of the S. fruticosa infusion (SFINF) and its major substance rosmarinic acid (RA) on amyloid beta 1–42 -induced cytotoxicity on SH-SY5Y cells together with p-GSK-3β activation were investigated. Their in vitro inhibitory effects against glycogen synthase kinase 3β, β-secretase, and casein kinase 1δ enzymes were also evaluated. The results showed that treatment with the all tested concentrations, SFINF significantly decreased Aβ 1–42-induced cytotoxicity and exhibited promising in vitro glycogen synthase kinase 3β inhibitory activity below 10 µg/mL (IC50 6.52 ± 1.14 µg/mL), in addition to β-secretase inhibition (IC50 86 ± 2.9 µg/mL) and casein kinase 1δ inhibition (IC50 121.57 ± 4.00). The SFINF (100 µg/mL and 250 µg/mL) also activated the expression of p-GSK-3β in amyloid beta 1–42 treated SH-SY5Y cells. The outcomes of this study demonstrated that the S. fruticosa infusion possessed activity to prevent amyloid beta 1–42 -induced neurotoxicity and provided proof that its mechanism may involve regulation of p-GSK-3β protein.
AtıfScopus18OpenAlex17
İncele - MakaleAçık Erişim2021Scopus SJRQ1Comprehensive biological and chemical evaluation of two seseli species (S. gummiferum and s. transcaucasicum)
Zengin, Gokhan; Stojković, Dejan; Mahomoodally, Mohamad Fawzi; Jugreet, Bibi Sharmeen; Paksoy, Mehmet Yavuz; Ivanov, Marija; Gašić, Uroš; Gallo, Monica; Montesano, Domenico
Seseli L. is one of the largest genera of the Apiaceae family widely known for their traditional uses as herbal remedies. In the present study, the methanolic and water extracts of two Seseli species, S. gummiferum and S. transcaucasicum were evaluated for their bioactive contents and biological activities. The total phenolic and flavonoid contents in the extracts ranged from 19.09 to 24.33 mg GAE/g and from 0.45 to10.09 mg RE/g, respectively. Moreover, while narcissin was detected as the most abundant component in the methanolic extract of S. transcaucasicum (261.40 µg/g), chlorogenic acid was identified as the major component in all the other extracts, although a high amount was also present in the methanolic S. transcaucasicum extract (107.48–243.12 µg/g). The total antioxidant capacity was also determined by the phosphomolybdenum assay (0.66–1.18 mM TE/g). Other antioxidant assays such as the radical scavenging assays (DPPH: 5.51–11.45 mg TE/g; ABTS: 43.46–51.91 mg TE/g), reducing assays (CUPRAC: 41.67–53.20 mg TE/g; FRAP: 31.26–34.14 mg TE/g), as well as the metal chelating activity assay (14.38–38.57 mg EDTAE/g) were conducted. All the extracts showed inhibitory potential against the enzyme’s amylase (0.12–0.78 mM ACAE/g), acetyl-and butyryl-cholinesterase (0.15–9.71 mg GALAE/g), while only the methanolic extracts acted as inhibitors of tyrosinase (107.15 and 109.37 mg KAE/g) and only the water extract of S. gummiferum displayed anti-glucosidase activity (0.13 mM ACAE/g). Interestingly, the methanolic extracts of both Seseli species showed lower cytotoxicity towards HaCaT cells (IC50: >500 µg/mL), compared to the water extracts (IC50: 267.8 and 321.41 µg/mL). Besides, only the methanolic extracts showed a slight wound healing effect (28.21 and 31.23%). All extracts showed antibacterial action against Staphylococcus lugdunensis (minimum inhibitory and bactericidal concentrations: 0.025–2 mg/mL). S. gummiferum methanolic extract, which exhibited the highest antibacterial potency was found to inhibit adhesion and invasion of S. lugdunensis to HaCaT cells as well. Taken together, this study demonstrated the two Seseli species to harbour interesting bioactive components, in particular polyphenolics and to exhibit several biological properties that could be further investigated for their potential exploitation as healing agents as supported by various traditional medicinal uses.
AtıfScopus16OpenAlex15İncele - MakaleAçık Erişim2020Scopus SJRQ3Genetic variation and molecular relationships taxa of conringia heist. EX FABR. (BRASSICACEAE) Based on rapd markers in Turkey
Sevgndgk, Emre; Paksoy, Mehmet Yavuz; Aydoğan, Melike; Topseçer, Feyzanur
In this study, genetic variation and phylogenetic analysis of 13 populations of 6 species belonging to Conringia genus spreading in Turkey were performed using RAPD markers. Genomic DNA isolation from the leaves of the Conringia plant samples was performed via using a commercial kit. Seven RAPD primers were used to identify the genetic diversity between the populations. Polymerase Chain Reaction (PCR) was performed using DNA samples and primers. PCR products were resolved using agarose gel electrophoresis and visualized under UV light. All gel images were analyzed, and the absence and presence of polymorphic bands were scored. The total of 34 DNA bands were detected by seven RAPD primers. PAUP 4.0b10 analysis program was used to calculate phylogenetic tree and genetic distances between the species. The phylogenetic tree was obtained using the UPGMA algorithm and it was composed of two clades. According to the PAUP analysis, the species having the closest distance between each other are C. planisiliqua (Ankara-AyaG) and C. planisiliqua (Ankara-Nallihan) with the value of 0.000 and those having the longest distance are C. grandiflora (Akseki Cukurkoy) and C. orientalis (Elazig-Baskil) with the value of 0.6000. The results suggest that the RAPD markers are useful tools to demonstrate the genetic relationships between populations of the Conringia species.
AtıfScopus6WoS3OpenAlex6İncele - MakaleYalnız künye2020Scopus SJRQ1Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study
Zengin, Gokhan; Sinan, Kouadio Ibrahime; Ak, Gunes; Mahomoodally, Mohamad Fawzi; Paksoy, Mehmet Yavuz; Picot-Allain, Carene; Glamocilja, Jasmina; Sokovic, Marina; Jekő, József; Cziáky, Zoltán
Several Apiaceae species, used as both food and in complementary and alternative medicine, represents a rich source of potential valuable phytopharmaceuticals which necessitates scientific contemplation. In the present study, the antioxidant, enzyme inhibitory, antimicrobial, and cytotoxic properties of methanol extracts of seven Apiaceae species, (Chaerophyllum macrospermum (Willd. ex Spreng.) Fisch. & C.A.Mey. ex Hohen, Ferula rigidula Fisch. ex DC., Ferula orientalis L., Prangos ferulacea Lindl., Prangos peucedanifolia Fenzl., Ferulago setifolia K. Koch, and Pimpinella anthriscoides Boiss.) were evaluated. Species belonging to the Prangos genus exhibited the highest total phenolic content, namely P. peucedanifolia and P. ferulacea, with values of 47.90 and 44.44 mg gallic acid equivalent/g extract, respectively. P. peucedanifolia also displayed the highest radical scavenging capacity (81.53 and 102.70 mg Trolox equivalent [TE]/g extract for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), respectively) and reducing power (165.87 and 100.09 mg TE/g extract for cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP), respectively). C. macrospermum showed the most potent inhibition against Alzheimer's disease related enzymes, namely acetylcholinesterase (4.53 mg galantamine equivalent [GALAE]/g extract) and butyrylcholinesterase (3.22 mg GALAE/g extract). P. ferulacea (131.94 mg kojic acid (KAE) equivalent/g extract) and P. peucedanifolia (4.97 mmol acarbose equivalent (ACAE)/g extract) were potent inhibitors of tyrosinase and α-glucosidase, respectively. In general, studied species were able to reduce cellular viabilities. P. peucedanifolia possessed promising antibacterial potential against Bacillus cereus (Minimum inhibition concentration (MIC): 0.37 mg/mL), L. monocytogenes (MIC: 0.56 mg/mL), P. aeruginosa and Escherichia coli (MIC: 0.27 mg/mL), Salmonella typhimurium and Enterobacter cloacae (MIC: 0.75 mg/mL). F. rigidula showed the highest antifungal effect against Aspergillus ochraceus and Trichoderma viride (MIC: 0.10 mg/mL). The present findings could be the scientific starting point towards the pharmaceutical and/or commercial utilization of these Apiaceae species.
AtıfScopus65OpenAlex64İncele - MakaleAçık Erişim2020Scopus SJRQ3ANTI-UREASE, TOTAL PHENOLIC CONTENT AND ANTIOXIDANT ACTIVITIES OF SOME Inula L. (ASTERACEAE) TAXA IN TURKEY
Sevindik, Emre; Aydin, Sinem; Paksoy, Mehmet Yavuz; Sokmen, Bahar Bilgin
The genus Inula belongs to family Asteraceae and it is medicinally important because it possesses cytotoxic, anticancer, hepatoprotective, antibacterial and anti-inflammatory properties. The aim of this research was to explore antioxidant and anti-urease activities of fifteen Inula taxa in Turkey. Ethanol extracts of Inula taxa were obtained by Soxhlet extraction. Antioxidant activity was determined through total antioxidant activity, total phenolic content and copper reducing antioxidant capacity (CUPRAC) analyses. The highest total phenolic content and total antioxidant capacity were found in I. orientalis (158.54±0.002 µg GAE/mL) and I. macrocephala (189.16±0.002 µg AAE/mL). CUPRAC activity increases with the increasing concentration of the extracts and the standard. Moreover, all the tested plants exhibited better anti-urease activity than standard thiourea except for I. anatolica and I. thapsoides subsp. thapsoides. Results obtained from this study demonstrate that Inula species might be utilized as a probable natural source in the pharmaceutical and food industries but further and more specific studies are needed to determine active antioxidative and anti-urease compounds in the extracts.
AtıfScopus8WoS7OpenAlex10İncele - MakaleYalnız künye2019Genetic Diversity Analysis of Aydın/Turkey Dittrichia viscosa (L). Greuter (Asteraceae) Populations Using RAPD Markers
Paksoy, Mehmet Yavuz; Sevindik, Emre; Uzun, Sefa
In this study, we performed a genetic diversity using RAPD markers for some Dittrichia viscosa populations grown in the Aydın region of Turkey. Total genomic DNA isolation from the leaves of Dittrichia viscosa was performed using commercial kit. eight RAPD primers were used to determine genetic diversity among populations. Polymerase Chain Reaction (PCR) was performed with all DNA samples and primers with ability of scoreing band. PCR products were run in agarose gel and visualized under UV light. They scored as there were bands (1) and no bands (0) at all gel images and their files were created. A total of 50 characters were obtained from the primers. Phylogenetic relationships and genetic distances between the cultivars were calculated by using the PAUP* 4.0b10 analysis program. According to the PAUP data, the closest genetic distance was determined 0.20000 and between Central and İncirliova populations, the most distant genetic distance were determined 0.36842 between İncirliova and Koçarlı populations. In the phylogenetic analysis has been obtained using UPGMA algorithms and phylogenetic tree consist of two clades. The results also propose that RAPD markers are useful tools for indicating genetic relationships among Dittrichia viscosa populations.
- MakaleAçık Erişim2019Phylogenetic Analysis of Chrysochamela (Fenzl) Boiss. (Brassicaceae) Taxa Growing in Turkey
Paksoy, Mehmet Yavuz; Sevindik, Emre; Topseçer, Feyzanur; Aydoğan, Melike
In this study, we performed a genetic diversity analysis using RAPD (Random AmplifiedPolymorphic DNA) and ISSR (Inter simple sequence repeat) markers for some Chrysochamelaspecies growing in Turkey. PCR was performed using RAPD and ISSR primers and genomic DNAsamples from each specimen, and the resulting bands were scored. Phylogenetic relationships andgenetic distances between the studied taxa were calculated using the PAUP analysis program.According to the RAPD analysis, the closest genetic distance was found to be 0.20000 between C.noeana populations, while the most distant values were found as 0.60000 between C. noeana and C.elliptica. The ISSR analysis also revealed the closest genetic distance as 0.34043 between C. noeanapopulations, while the most distant values were found to be 0.55319 between C. noeana and C.elliptica. UPGMA (unweighted pair group method with arithmetic mean) dendrogram generated forboth RAPD and ISSR analyses consisted of two groups. As a result, it was found that RAPD datawere more appropriate for comparison with the previous anatomical and morphological data of the studied taxa.
AtıfOpenAlex1TR Dizin1
İncele - MakaleYalnız künye2019Scopus SJRQ4MICROMORPHOLOGICAL AND ANATOMICAL INVESTIGATIONS ON CONRINGIA HEIST. EX FABR.
Selvi, Selami; Aladi, Hatice Inci; Paksoy, Mehmet Yavuz
The micromorphological and anatomical investigations on 6 taxa of Conringia Heist. ex Fabr. growing in Turkey were carried out. The anatomy of root, stem and leaves was examined in detail. In micromorphological studies stem and leaf surface of species was examined. Mesophyll type of lamina is dorsiventral (Conringia planisiliqua, C. persica, C. austriaca) and equifacial (C. clavata, C.grandiflora, C. orientalis). Stomata situated on both surfaces, are anisocytic and rarely anomocytic types. Crystals of calcium oxalate observed in only one species (C. grandiflora) was found to have cubic type parenchyma cells of the stem and leaf In micromorphological studies the surface of the stem and leaves were found to be glabrous. Epidermal surface of leaves was observed to be covered with waxy cuticular particles. Anticlinal walls of the adaxial cells are undulate and rarely straight and anticlinal walls of abaxial epidermis are undulate and rarely sinuate. Periclinal walls were found to be covered with upper waxy layer which was flat. A diagnostic key based on combined stem, leaf and leaf epidermal characteristics are presented. The leaf mesophyll structures, stem vascular bundles number, lignified or unlignified of sclerenchyma, epidermal surface and absence or presence of crystals were found to be important characters for the identification of Conringia species.
AtıfWoS1İncele - MakaleYalnız künye2019Scopus SJRQ2Pollen morphology of three Chrysophthalmum schultz bip. (Asteraceae) species in Turkey
Karlıoǧlu Kılıç, Nurgül; Paksoy, Mehmet Yavuz; Özdemir, Emrah
The pollen morphology of three species of the genus Chrysophthalmum Schultz Bip. (Asteraceae) found in Turkey were studied with light microscope (LM) and scanning electron microscope (SEM). The three species were C. dichotomum Boiss. & Heldr., C. gueneri Aytac & Anderb., and C. montanum (DC.) Boiss. Pollen grains of the Chrysophthalmum species were identified as spheroidal and their apertures were shown to be tricolporate. The polar and equatorial axes, distance between colpus apices, length/width of colpus, length/width of porus, exine thickness, and length/base of spine were measured on the pollen grains. Pollen ornamentation of the three species was identified as echinate in LM and echinate-microperforate in SEM. These studied species were distinguished from each other using Kruskal–Wallis and Dunn’s test. The results indicate that pollen characteristics could be useful for distinguishing the examined species.
AtıfWoS1OpenAlex1İncele - MakaleAçık Erişim2019Scopus SJRQ3Bioactivity-guided isolation of anti-inflammatory principles from Cistus parviflorus Lam.
Gürbüz, Perihan; Doğan, Şengül Dilem; Çelik, Gizem Nur; Bekci, Hatice; Cumaoğlu, Ahmet; Gündüz, Miyase Gözde; Paksoy, Mehmet Yavuz
Bioactivity-guided fractionation and purification of Cistus parviflorus led to the isolation of two flavan-3-ol derivatives; gallocatechin (1) and epigallocatechin (2) and two flavonoid glycosides; avicularin (3) and trans-tiliroside (4). The structures of the compounds were elucidated on the basis of NMR and ESIMS data. All compounds were isolated from C. parviflorus for the first time. Compounds 2 and exhibited antiinflammatory activity through decreasing the NOS2 and COX2 levels on LPS+IFN-γ treated RAW 264.7 cells. Molecular docking studies of avicularin, the most potent compound, were carried out in the active sites of NOS2 and COX2 to predict the most plausible binding modes and support the experimental data.
AtıfScopus7OpenAlex8TR Dizin2İncele - MakaleAçık Erişim2019Scopus SJRQ1New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species
Zengin, Gokhan; Paksoy, Mehmet Yavuz; Aumeeruddy, Muhammad Zakariyyah; Glamocilja, Jasmina; Sokovic, Marina; Diuzheva, Alina; Jekő, József; Cziáky, Zoltán; Rodrigues, Maria João; Custodio, Luisa
Bunium species have been reported to be used both as food and in traditional medicines. The scientific community has attempted to probe into the pharmacological and chemical profiles of this genus. Nonetheless, many species have not been investigated fully to date. In this study, we determined the phenolic components, antimicrobial, antioxidant, and enzyme inhibitory activities of aerial parts of four Bunium species (B. sayai, B. pinnatifolium, B. brachyactis and B. macrocarpum). Results showed that B. microcarpum and B. pinnatifolium were strong antioxidants as evidenced in the DPPH, ABTS, CUPRAC, and FRAP assays. B. brachyactis was the most effective metal chelator, and displayed high enzyme inhibition against cholinesterase, tyrosinase, amylase, glucosidase, and lipase. The four species showed varied antimicrobial activity against each microorganism. Overall, they showed high activity against P. mirabilis and E. coli (MIC and MBC <1 mg mL−1). B. brachyactis was more effective against Aspergillus versicolor compared to the standard drug ketoconazole. B. brachyactis was also more effective than both ketoconazole and bifonazole against Trichoderma viride. B. sayai was more effective than ketoconazole in inhibiting A. fumigatus. B. sayai was most non-toxic to HEK 293 (cellular viability = 117%) and HepG2 (cellular viability = 104%). The highest level of TPC was observed in B. pinnatifolium (35.94 mg GAE g−1) while B. microcarpum possessed the highest TFC (39.21 mg RE g−1). Seventy four compounds were detected in B. microcarpum, 70 in B. brachyactis, 66 in B. sayai, and 51 in B. pinnatifolium. Quinic acid, chlorogenic acid, pantothenic acid, esculin, isoquercitrin, rutin, apigenin, and scopoletin were present in all the four species. This study showed that the four Bunium species are good sources of biologically active compounds with pharmaceutical and nutraceutical potential.
AtıfScopus22OpenAlex23İncele - MakaleAçık Erişim2019Scopus SJRQ1Phytochemical characterization and bioactivities of five Apiaceae species: Natural sources for novel ingredients
Zengin, Gokhan; Mahomoodally, Mohamad Fawzi; Paksoy, Mehmet Yavuz; Picot-Allain, Carene; Glamocilja, Jasmina; Sokovic, Marina; Diuzheva, Alina; Jekő, József; Cziáky, Zoltán; Rodrigues, Maria João
Several species of the Apiaceae family have been employed in traditional cultures for their curative virtues. The present study focused on five Apiaceae species, (Falcaria vulgaris (FV), Smyrniopsis aucheri (SA), Smyrniopsis munzurdagensis (SM), Smyrnium cordifolium (SC), and Actinolema macrolema (AM)). The antioxidant, enzyme inhibitory (α-amylase, α-glucosidase, acetyl- and butyrylcholinesterase, lipase, and tyrosinase), antimicrobial, phytochemical, and cytotoxicity profiles of the methanol extracts of the selected Apiaceae species were determined. SC extract (35.68 mg gallic acid equivalent/g extract) possessed the highest phenolic content while the AM extract (56.79 mg rutin equivalent/g extract) had the highest flavonoid content. HPLC-ESI-MS (High performance liquid chromatography-electrospray tandem mass spectrometry) analyses showed presence of ferulic acid in all the five species. SC extract exhibited high radical scavenging (59.28 and 94.31 mg Trolox equivalent [TE]/g extract, DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid), respectively) and reducing activity (161.44 and 113.62 mg TE/g extract, for CUPRAC (cupric reducing antioxidant capacity) and FRAP (ferric reducing antioxidant power), respectively). SM extract exhibited the highest cholinesterase's inhibitory action (3.82 and 4.76 mg galantamine equivalent/g extract, for acetyl- and butyrylcholinesterase, respectively). The extracts showed higher inhibition against α-glucosidase (7.32-11.99 mmol acarbose equivalent [ACAE]/g extract) compared to α-amylase (0.51-0.55 mmol ACAE/g extract). SC extract was the most active (137.54 mg kojic acid equivalent/g extract) tyrosinase inhibitor and FV extract (113.75 mg Orlistat equivalent/g) the best lipase inhibitor. SM extract showed potent antibacterial effect against B. cereus (MIC (minimum inhibitory concentration) 0.180 mg/mL), P. mirabilis (MIC 0.180 mg/mL), M. flavus (MIC 0.560 mg/mL), P. aeruginosa (MIC 0.275 mg/mL), and S. typhimurium (MIC 1.500 mg/mL). FV extract (MIC 0.140 mg/mL) suppressed A. fumigatus growth. Cytotoxicity was assessed on murine macrophage (RAW 264.7), human embryonic kidney (HEK 293), and human hepatocellular carcinoma (HepG2) cell lines. FV (60.3%) and SM (57.4%) showed the highest reduction on RAW 264.7 cellular viability, whereas SM (74.1%) showed toxicity against HepG2. This study supports that the Apiaceae species could be considered as promising candidates for the development of novel pharmacophores for the management of several human ailments.
AtıfScopus51OpenAlex47İncele - MakaleAçık Erişim2018Scopus SJRQ2Chemical Composition of the Essential Oil and Antimicrobial Activity of Scaligeria DC. Taxa and Implications for Taxonomy
Baldemir, Ayse; Demirci, Betul; Paksoy, Mehmet Yavuz; Ilgün, Selen; Kosar, Mberra; Baser, Kemal Husnu Can; Demirci, Fatih
AtıfOpenAlex5İncele - MakaleAçık Erişim2018Scopus SJRQ2Pollen morphology of Scaligeria DC. (Apiaceae) in Turkey
Baldemir, Ayse; Alan, Senol; Sahien, Aydan Acar; Paksoy, Mehmet Yavuz; Pinar, N. Munevver
In this study, the pollen morphology of all Scaligeria DC. species distributed in Turkey were studied with light and scanningelectron microscopy for the first time. The aim is to contribute to knowledge of the variation among seven Scaligeria species, which havetaxonomic problems, based on pollen morphological characteristics by population analysis. The pollen is radially symmetrical, isopolar,and tricolporate in all examined species. Pollen grains are prolate and subprolate with the polar axes ranging from 18.4 to 37 μm andthe equatorial axes from 9.8 to 30 μm. Their polar shapes are triangular, triangular to subcircular, circular to subcircular, or triangularto subtriangular. Several types of exine ornamentations have been observed on pollen by scanning electron microscopy. Numericalanalysis showed that pore structure, the ratio of P/E, and ornamentation in the polar and equatorial views are most valuable variablesfor separating the Scaligeria species. All S. lazica taxa were grouped together and S. capillifolia and S. tripartita were the external taxadue to cluster and PCA analysis.
AtıfOpenAlex13TR Dizin2İncele - MakaleYalnız künye2018Scopus SJRQ2Survey of wild food plants for human consumption in Karaisalı (Adana-Turkey)
Güneş, Suzan; Savran, Ahmet; Paksoy, Mehmet Yavuz; Çakılcıoğlu, Uğur
This study identified not only the wild plants collected for food purposes by local people of Karaisalı County in the Mediterranean Region, but also the uses and local names of these plants. Field study was carried out over a period of approximately 2 years (2008–2010). During this period, 76 vascular plant specimens were collected. Demographic characteristics of participants, vernacular plant names, edible parts and utilization methods of the plants were investigated and recorded. In the scope of the study, the plant species were collected; herbarium materials were prepared; and the specimens were entitled. In addition, the use-value of the species was determined and was calculated for the food plants included in the study. A total of 76 food plants belonging to 30 families were identified in the region. The most common families are: Asteraceae (12 plants), Lamiaceae (10 plants), Rosaceae (9 plants), Polygonaceae (5 plants), Apiaceae (4 plants). The study showed that the plants used are either eaten raw or ripe, cooked as vegetable dish, consumed as jam, consumed as coffee, as spice, frying in oil or baked to be served as dishes such as stew, pie made by roasting the leaves, prepared sour souce is added to food. During this ethnobotanical research, it was verified that wild edible plants play an important role in diet in Karaisalı. We examined whether the plants used had literature records or not. Varied usages of a number of plants have been recorded for the first time by us. Tree of those plant are endemic. The plant flora of Karaisalı is threatened by such factors as grazing, expansion of new agricultural lands, and unsustainable picking of plants to generate income. Steps should be taken immediately to ensure the inclusion of relevant flora within conservation designations.
AtıfScopus40İncele - MakaleYalnız künye2017Aydın/Türkiye’de Yayılış Gösteren Dittrichia L. (Asteraceae) Cinsinin Kimyasal Kompozisyonunun Değerlendirilmesi
Paksoy, Mehmet Yavuz; Sevindik, Emre
Küçük bir cins olarak Greuter tarafından tanımlanan Dittrichia (Asteraceae) cinsi, önceden Inula’nın bir bölümü olarak biliniyordu ve Atlantik Avrupa ülkelerinde, Ortadoğu ve Akdeniz bölgesinde yayılış göstermektedir. Bu çalışma da Dittrichia cinsine ait bitkilerden elde edilen uçucu yağların kimyasal bileşimi incelenmiştir. Çalışma materyali Dittrichia viscosa (L). Greuter ve Dittrichia graveolens (L.) Greuter Eylül-Ekim 2015 tarihinde Batı Anadolu (Aydın/Türkiye) ekolojik koşullarında toplanmıştır. Yaprakların uçucu yağları Clevenger cihazıyla ekstrakte edildi. Esansiyel yağ bileşimleri Gaz Kromatografisi-Kütle Spektrometresi (GC-MS) cihazı ile belirlendi. Gaz kromatografisi-kütle spektrometresi analizinin sonuçları, D. graveolens bitkisinden elde edilen uçucu yağda levo-bornyl acetate en yüksek düzeyde (% 25.23) olduğunu gösterdi. D. viscosa bitkisinde ise 2,4-diokso-3-metil6-izopropil pirido [2,3-b]- [1,4] pirazin en yüksek düzeyde (% 29.02) olduğu belirlendi.
AtıfTR Dizin1İncele - MakaleYalnız künye2017Tanacetum zahlbrucknerı (náb.) grıerson' nun sekonder metabolitleri ve antioksidanetkileri*
Paksoy, Mehmet Yavuz; Gürbüz, Perihan; Karatoprak, Gökçe Şeker; Koşar, Müberra; Eroğlu, Duygu; Doğan, Şengül
Bu çalışma kapsamında Asteraceae familyasına dahilendemik bir tür olan Tanacetum zahlbruckneri (Náb.)Grierson bitkisinin toprak üstü kısımlarından hazırlananmetanol ekstresinin DPPH?, ABTS?+süpürücü aktivitesi ve ?-karoten-linoleik asitle oksidasyon yöntemi ile antioksidan aktiviteleri, Folin- Ciocalteuyöntemiyle toplam fenol, flavonit ve flavonol içeriğiincelenmiştir. Metanol ekstresinden sıvı-sıvı partisyonyöntemiyle n-hekzan, dietil eter, diklorometan ve nbutanol ekstreleri hazırlanmış, n-butanol ekstresindençeşitli kromatografik yöntemler kullanılarak, klorojenikasit (1), rutin (2) ve konduritol F (3) izole edilmiştir.Elde edilen bileşiklerin yapıları spektroskopik yöntemler (IR,1H-NMR,13C-NMR, 2D-NMR, IR, MS) kullanılarakaydınlatılmıştır. Bu çalışma ile Konduritol F Tanacetumtürlerinden ilk defa izole edilmiştir. Klorojenik asit verutinin bitkinin metanol ekstresindeki kantitatif tayiniYüksek Basınçlı Sıvı Kromatografisi ile gerçekleştirilmiştir. İzole edilen bileşiklerin antioksidan aktiviteleri ölçülmüş ve klorojenik asitin aktivitesi, rutin vemetanol ekstresinden daha yüksek bulunmuştur.
AtıfTR Dizin1İncele - MakaleYalnız künye2017Scopus SJRQ4COMPARATIVE VEGETATIVE ANATOMY AND FRUIT MICROMORPHOLOGY OF THE GENUS KUNDMANNIA SCOP. AND THEIR TAXONOMICAL SIGNIFICANCE
Paksoy, Mehmet Yavuz; Polat, Ridvan; Çakilcioglu, Ugur
Kundmannia Scop. is a genus of the Apiaceae (Umbelliferae) family which consists of 463 genera and ca. 3500 species. Kundmannia belongs to the Oenantheae tribe and are well represented in Spain, France, Italy, Turkey, Syria and North Africa where they grow on calcareous or siliceous soils. In this study; fruit micromorphology and the vegetative anatomy of the Kundmannia species growing in Turkey were compratively examined for the first time. The anatomical sections were taken from the stem, ray, leaf and and petiole of the plants for taxonomic deduction. Various tissues of taxa were given comparative micro anatomical measurements according to the anatomical studies, lignified or non-lignified medullary rays in stems, stomata types (diacytic and anomocytic), stomata index ratio (0.58 - 0.7), fruit shape and fruit epidermal surface are considered as important anatomical characters. In the fruit micromorphology, the cells on the mericarp surface have seen as striate and rugulate while the surface between the two ribs in the species have observed rugulate or striate. Fruit micromorphology and vegetative anatomy of the genus Kundmannia has not been studied before. However, the anatomical structure of the genus has been elucidated in this study, for the first time.
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