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- MakaleAçık Erişim2020Scopus SJRQ4Investigation of curcumin role on doxorubicin-induced tissue damage in terms of trace metal levels using etaas
Ince, Olcay Kaplan; Kandemir, Fatih Mehmet; Ince, Muharrem; Benzer, Fulya; Onal, Ali; Kucukler, Sefa
Doxorubicin (DXR) is one of the commonly used chemotherapeutic agents, which is highly toxic and causes gastrointestinal and cardiac toxicity. Curcumin is used as a spice and coloring agent in food, but also possesses anti-proliferating, potent antioxidant, antitumor-promoting and anti-carcinogenic properties in vitro and in vivo. In this study, the change in element concentrations in the tissues of healthy animals was examined by administering doxorubicin and curcumin separately, or both at the same time. For this purpose, 35 wistar albino male rats were selected and randomly divided into five groups of seven each. The objective of this study was to assess and compare the levels of copper, iron, zinc and selenium in the liver, kidney, heart, and testis of the control group and in the doxorubicin-induced tissues. According to the results, the Cu, Fe, Zn, Se amounts and the Cu/Fe, Cu/Zn, and Cu/Se ratios were present at different levels in each of the five groups. In terms of element concentration, the most affected tissue by doxorubicin application is the heart, and the least affected is the kidney. The ratios of Cu/Fe and Cu/Se in the liver and the heart were highest in Group II and Group III, respectively.
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İncele - MakaleYalnız künye2019Scopus SJRQ4Application of response surface methodological approach to optimize removal of Cr ions from industrial wastewater
Ince, Muharrem; Ince, Olcay Kaplan
In the present study, the adsorption of chromium (Cr) onto clay using response surface methodology (RSM) was investigated as an efficient approach for examining predictive model building and optimization. To optimize experimental variables and predictive regression models, statistical design models were carried out. A five-level four-fac-tor central composite design (CCD) combined with RSM was performed with synthetic aqueous solutions on natural clay. The experimental variables included pH and agitation speed and were selected for optimization. The Cr ions ideal removal conditions were obtained using pH 5.0, contact time 23.0 minutes, adsorbent dosage of 69.4 mg, and agitation speed of 135 rpm. Chromium removal efficiency was found at 23.16 mg g-1. The independent variables significance and their interactions were verified by means of the analysis of variance (ANOVA). These results were justified by the relatively high correlation coefficients (R2 = 0.9902) of the statistical prediction. Clay and Cr loaded clay were characterized by X-ray dif-fractometer (XRD) and energy dispersive spectroscopy (EDS). The proposed adsorption process efficiently removed the Cr ions present in various aqueous media and was also applied to various industrial wastewaters.
AtıfScopus5İncele - MakaleAçık Erişim2019Scopus SJRQ4Modeling approach with Box-Behnken design for optimization of Pb bioaccumulation parameters in Gammarus pulex (L., 1758)
Pala, Aysegul; Serdar, Osman; Ince, Muharrem; Onal, Ali
The aim of this research was to evaluate the suitability of Gammarus pulex (L., 1758), an amphipod crustacean, as a bio-monitor for lead (Pb). A Box– Behnken experimental approach combined with response surface modeling (RSM) and quadratic programming was employed to increase the knowledge about Pb2+ bioaccumulation in Gammarus pulex (L., 1758). Independent variables, such as temperature ranging from 18 to 22 ºC, contact time from 8 to 48 hours, and Pb2+ ion solution concentrations from 50 to 100 µg L-1, were studied and tested using analysis of variance (ANOVA). The standardized effects of the independent variables and their interactions on the dependent variable were also investigated according to a Pareto chart. The selected variables' optimum values were obtained by solving the quadratic regression model along with analyzing the response surface contour plots. Optimum experimental conditions were obtained at 22.0 ºC, contact time of 8 hours, and Pb concentration at 69.5 µg L-1. Based on the Box-Behnken design, the applied model is significant because the model F-value and R2 were obtained at 77.80 and 0.9901, respectively. Bioaccumulation of Pb was determined using electrothermal atomic absorption spectrometry (ETAAS). The obtained data suggest that G. pulex can be used as a Pb biomonitor.
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