Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Zengin, Gokhan(4)
- Ak, Gunes(2)
- Angeloni, Simone(2)
- Caprioli, Giovanni(2)
- Mahomoodally, Mohamad Fawzi(2)
- Sinan, Kouadio Ibrahime(2)
- Acar, Mikail(1)
- Aglar, Erdal(1)
- Akan, Hasan(1)
- Aydin, Sevinc(1)
- Bouyayha, Abdelhakim(1)
- Cakilcioglu, Ugur(1)
- Cakılcıoglu, Ugur(1)
- Custodio, Luisa(1)
- Cziáky, Zoltán(1)
- Eldahshan, Omayma(1)
- Fahmy, Nouran(1)
- Fayez, Shaimaa(1)
- Glamocilja, Jasmina(1)
- Guler, Osman(1)
- Jekő, József(1)
- Kaplan, Alevcan(1)
- Karakavuk, Emrah(1)
- Kucuker, Emine(1)
- Kurt-Celep, İnci(1)
- Maggi, Filippo(1)
- Mahomoodally, Mohamad F.(1)
- Mollica, Adriano(1)
- Mustafa, Ahmed M.(1)
- Nilofar, Nilofar(1)
- Ogurlu, Ferhat(1)
- Ozcengiz, Ceyda Kizgin(1)
- Paksoy, Mehmet Yavuz(1)
- Pereira, Catarina G.(1)
- Picot-Allain, Carene(1)
- Polat, Rıdvan(1)
- Rodrigues, Maria João(1)
- Sabancı, Serdal(1)
- Sadeer, Nabeelah(1)
- Sevim, Esra(1)
Yayınlar
- MakaleYalnız künye2026Scopus SJRQ1Quality Enhancement of Rhubarb (Rheum ribes L.) Jam by Ohmic Heating
Özdede, Gizem Merve; Özakdağ, Işılay; Sevim, Esra; Karakavuk, Emrah; Sabancı, Serdal
This study aims to comparatively investigate the production of jam from Rheum ribes L., a plant known for its functional properties, using both conventional and ohmic heating methods, and to evaluate the effects of these methods on quality parameters. Ohmic heating was applied at three different voltage gradients (25, 30, and 35 V/cm) and compared with conventional heating. In both methods, jam samples were produced until they reached a total soluble solids (TSS) content of 66%, after which total phenolic content (TPC), antioxidant activity, ascorbic acid (vitamin C), hydroxymethylfurfural (HMF), and individual phenolic compounds were analyzed. According to the results, the highest TPC (488.37 mg gallic acid equivalent [GAE]/kg), antioxidant activity (595.6 mg ascorbic acid equivalent [AAE]/kg), and vitamin C content (23.6 ppm) were obtained at 35 V/cm. In contrast, the conventional method yielded significantly lower values for these parameters and a higher HMF content (29.9 ppm). Ohmic heating enabled a much shorter processing time, reducing energy consumption by approximately sixfold and contributing to better retention of nutritional components. Additionally, higher voltage gradients resulted in improved preservation of individual phenolic compounds (such as gallic acid, catechin, and rutin). The findings indicate that, compared to the conventional method, ohmic heating offers higher efficiency, better retention of bioactive compounds, and a more sustainable production approach due to its lower energy requirement.
- MakaleYalnız künye2025Scopus SJRQ2Influence of putrescine treatment on quality and biochemical characteristics of hawthorn fruit during cold storage
Kucuker, Emine; Aglar, Erdal; Ogurlu, Ferhat; Ozcengiz, Ceyda Kizgin; Sumbul, Ahmet
Post-harvest quality and product losses are significant for hawthorn fruits, which have a short shelf life and limited marketing period. This study examined the effects of putrescine applications to maintain the physical quality and biochemical contents of hawthorn fruits and extend their shelf life during cold storage. Hawthorn fruits were treated with different doses of putrescine (0.5 mM, 1 mM, and 2 mM) and stored for 30 days. The effects of putrescine applications on weight loss, decay rate, fruit firmness, soluble solids content (SSC), titratable acidity (TA), total phenolic content, total antioxidant content, individual phenolic compounds, and organic acid properties were evaluated on the 10th, 20th, and 30th days of storage. At the end of the cold storage, the lowest weight loss and decay rate and the highest fruit firmness were observed in the 1 mM putrescine application. In general, putrescine applications maintained total phenolic content, with the increase in total antioxidant content continuing until the 20th day. The highest increase in total phenolic and total antioxidant content was observed with the 1 mM putrescine application. Succinic acid, a decreasing phenolic compound, was identified as the primary acid in hawthorn fruits throughout storage. The storage period and putrescine application dose caused increases and decreases in phenolic compounds. Gallic acid was determined as the highest phenolic compound in hawthorn fruit. The 1 mM putrescine application was found to be the most effective application for organic acids and phenolic compounds. Putrescine, one of the main polyamines, was shown to be an effective method for maintaining the quality and shelf life of hawthorn fruit. Additionally, this study is expected to serve as a foundation for future similar studies.
AtıfScopus4WoS4OpenAlex3
İncele - MakaleYalnız künye2024Scopus SJRQ3Assessing the Chemical Composition, Antioxidant and enzyme Inhibitory Effects of Pentapleura subulifera and Cyclotrichium glabrescens Extracts
Nilofar, Nilofar; Zengin, Gokhan; Acar, Mikail; Bouyayha, Abdelhakim; Youssra, Aalilou; Eldahshan, Omayma; Fayez, Shaimaa; Fahmy, Nouran
The Lamiaceae family, encompassing diverse plant species, holds significant value in food, medicine, and cosmetics. Within this family, Pentapleura subulifera and Cyclotrichium glabrescens, relatively unexplored species, were investigated for their chemical composition, antioxidant capacity, and enzyme-inhibiting effects. The chemical composition of hexane, methanolic, and aqueous extracts from P. subulifera and C. glabrescens were analyzed using LC-ESI-MS/MS and the non-polar hexane fraction was investigated via GC-MS. The antioxidant potential of the extracts was determined through radical scavenging, reducing power and metal chelating assays. Additionally, inhibitory activity against six enzymes – acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, amylase, and glucosidase – was examined. The aqueous extract of P. subulifera and the methanolic extract of C. glabrescens exhibited elevated phenolic content at 129.47 mg gallic acid equivalent (GAE)/g and 55.97 mg GAE/g, respectively. Chemical profiling of the constituents of the two plant species resulted in the identification of a total of twenty compounds. The majority of which belonged to flavonoids and quinic acid derivatives, primarily concentrated in the methanol and aqueous extracts. Among all antioxidant assays, the aqueous extracts of P. subulifera demonstrated superior antioxidant activity, with the highest recorded activity of 404.93 mg trolox equivalent (TE)/g in the cupric reducing antioxidant capacity (CUPRAC) test. Meanwhile, the hexane extract of C. glabrescens exhibited the highest AChE inhibitory activity at 2.71 mg galanthamine equivalent (GALAE)/g, followed by the methanol extract of P. subulifera at 2.41 mg GALAE/g. These findings unequivocally establish the notable antioxidant and enzyme inhibitory activity of P. subulifera and C. glabrescens extracts, underscoring their potential as a source of valuable natural antioxidants.
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İncele - Kitap BölümüYalnız künye2024Effect of ecosystems and agricultural practices on Physalis peruviana phytochemicals
Aydin, Sevinc
As a result of the gradual decrease in natural resources and the increase in chronic diseases caused by unhealthy nutrition, the inclination among consumers toward food products that are both biologically active and beneficial, and environmentally friendly, is increasing. Therefore, environmental factors and agricultural practices that affect the amount of biologically active ingredients in these products have gained importance and become the subject of numerous scientific studies. Goldenberry (Physalis peruviana) is a yearly plant that is grown in mild climates, and it is a plant that is first planted in seed trays for primary development and then in the field for fruit production. Both its leaves, trunk, and roots have medicinal properties and its fruit is rich in components such as vitamins A and C, iron and phosphorus, flavonoid, and carotenoid which have made this plant, and particularly its fruit, more attractive. The amount and biological effect of these components, which are known as secondary metabolites, vary depending on the soil and the climate where this plant is grown and agricultural practices. With this compilation study, our aim is to summarize the studies that examined the positive or negative effects of environmental conditions that affect goldenberry cultivation and agricultural practices applied to increase the yield of the bioactive phytochemical ingredients of this plant, and thus to provide insight for relevant studies to be conducted.
AtıfScopus6OpenAlex5İncele - MakaleAçık Erişim2023Scopus SJRQ2Unraveling the chemical profile, antioxidant, enzyme inhibitory, cytotoxic potential of different extracts from Astragalus caraganae
Kurt-Celep, İnci; Zengin, Gokhan; Uba, Abdullahi I.; Caprioli, Giovanni; Mustafa, Ahmed M.; Angeloni, Simone; Cakilcioglu, Ugur; Guler, Osman; Kaplan, Alevcan; Sharmeen, Jugreet
Six extracts (water, ethanol, ethanol-water, ethyl acetate, dichloromethane, and n-hexane) of Astragalus caraganae were studied for their biological activities and bioactive contents. Based on high-performance liquid chromatography-mass spectrometry (HPLC-MS), the ethanol-water extract yielded the highest total bioactive content (4242.90 µg g−1), followed by the ethanol and water extracts (3721.24 and 3661.37 µg g−1, respectively), while the least total bioactive content was yielded by the hexane extract, followed by the dichloromethane and ethyl acetate extracts (47.44, 274.68, and 688.89 µg g−1, respectively). Rutin, p-coumaric, chlorogenic, isoquercitrin, and delphindin-3,5-diglucoside were among the major components. Unlike the dichloromethane extracts, all the other extracts showed radical scavenging ability in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay (8.73–52.11 mg Trolox equivalent [TE]/g), while all extracts displayed scavenging property in the 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging assay (16.18–282.74 mg TE/g). The extracts showed antiacetylcholinesterase (1.27–2.73 mg galantamine equivalent [GALAE]/g), antibutyrylcholinesterase (0.20–5.57 mg GALAE/g) and antityrosinase (9.37–63.56 mg kojic acid equivalent [KAE]/g) effects. The molecular mechanism of the H2O2-induced oxidative stress pathway was aimed to be elucidated by applying ethanol, ethanol/water and water extracts at 200 µg/mL concentration to human dermal cells (HDFs). A. caraganae in HDF cells had neither a cytotoxic nor genotoxic effect but could have a cytostatic effect in increasing concentrations. The findings have allowed a better insight into the pharmacological potential of the plant, with respect to their chemical entities and bioactive contents, as well as extraction solvents and their polarity.
AtıfScopus31OpenAlex36İncele - MakaleAçık Erişim2021Scopus SJRQ2Evaluation of chemical constituents and biological properties of two endemic Verbascum species
Zengin, Gokhan; Mahomoodally, Mohamad Fawzi; Sinan, Kouadio Ibrahime; Sadeer, Nabeelah; Maggi, Filippo; Caprioli, Giovanni; Angeloni, Simone; Mollica, Adriano; Stefanucci, Azzurra; Ak, Gunes
Members from the Verbascum genus are well appraised for their traditional uses against a variety of ailments including anti-inflammatory related disorders. This study thus attempts at validating the biological properties of two underexplored Verbascum members namely Verbascum euphraticum Benth. (V. euphraticum) and Verbascum oocarpum Murb. (V. oocarpum) in terms of their antioxidant and enzymatic inhibitory activities. Concentration of specific bioactive compounds was also established and molecular dynamic analysis were conducted on amassed data. Results showed that total phenolic and total flavonoid contents were higher for the methanolic extract of V. oocarpum compared to the methanolic extract of V. euphraticum. Phytochemical quantification revealed that the extraction solvents influenced the phytochemical composition of the extracts. Derivatives of phenolic acids such as 3-caffeoylquinic acid and 3,5-dicaffeoylquinic acid together with some phenolic acids i.e., gallic, vanillic, caffeic, syringic, p-coumaric and ferulic acid, have been detected in the extracts of both Verbascum species. Methanolic extracts of V. euphraticum and V. oocarpum yielded the highest total content of monitored compounds resulting in 162.758 and 3716.861 μg/g of dried weight extract, respectively. The methanolic extracts of both plants showed highest antioxidant potential while the ethyl acetate and hexane extracts were potent inhibitors of cholinesterase, α-amylase and α-glucosidase. Molecular dynamic results indicated that vanillic acid is able to make strong interactions with copper ions of tyrosinase, resulting into an effective anti-tyrosinase activity. In light of the above, both Verbascum species could be considered for future phytopharmaceutical development.
AtıfScopus36OpenAlex36İncele - MakaleYalnız künye2020Scopus SJRQ1Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study
Zengin, Gokhan; Sinan, Kouadio Ibrahime; Ak, Gunes; Mahomoodally, Mohamad Fawzi; Paksoy, Mehmet Yavuz; Picot-Allain, Carene; Glamocilja, Jasmina; Sokovic, Marina; Jekő, József; Cziáky, Zoltán
Several Apiaceae species, used as both food and in complementary and alternative medicine, represents a rich source of potential valuable phytopharmaceuticals which necessitates scientific contemplation. In the present study, the antioxidant, enzyme inhibitory, antimicrobial, and cytotoxic properties of methanol extracts of seven Apiaceae species, (Chaerophyllum macrospermum (Willd. ex Spreng.) Fisch. & C.A.Mey. ex Hohen, Ferula rigidula Fisch. ex DC., Ferula orientalis L., Prangos ferulacea Lindl., Prangos peucedanifolia Fenzl., Ferulago setifolia K. Koch, and Pimpinella anthriscoides Boiss.) were evaluated. Species belonging to the Prangos genus exhibited the highest total phenolic content, namely P. peucedanifolia and P. ferulacea, with values of 47.90 and 44.44 mg gallic acid equivalent/g extract, respectively. P. peucedanifolia also displayed the highest radical scavenging capacity (81.53 and 102.70 mg Trolox equivalent [TE]/g extract for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), respectively) and reducing power (165.87 and 100.09 mg TE/g extract for cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP), respectively). C. macrospermum showed the most potent inhibition against Alzheimer's disease related enzymes, namely acetylcholinesterase (4.53 mg galantamine equivalent [GALAE]/g extract) and butyrylcholinesterase (3.22 mg GALAE/g extract). P. ferulacea (131.94 mg kojic acid (KAE) equivalent/g extract) and P. peucedanifolia (4.97 mmol acarbose equivalent (ACAE)/g extract) were potent inhibitors of tyrosinase and α-glucosidase, respectively. In general, studied species were able to reduce cellular viabilities. P. peucedanifolia possessed promising antibacterial potential against Bacillus cereus (Minimum inhibition concentration (MIC): 0.37 mg/mL), L. monocytogenes (MIC: 0.56 mg/mL), P. aeruginosa and Escherichia coli (MIC: 0.27 mg/mL), Salmonella typhimurium and Enterobacter cloacae (MIC: 0.75 mg/mL). F. rigidula showed the highest antifungal effect against Aspergillus ochraceus and Trichoderma viride (MIC: 0.10 mg/mL). The present findings could be the scientific starting point towards the pharmaceutical and/or commercial utilization of these Apiaceae species.
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