Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Gul, Muhammet(102)
- Güler, Ömer(69)
- Akkurt, Nevzat(68)
- Tekin, H.O.(52)
- ALMisned, Ghada(49)
- Yucesan, Melih(49)
- Celik, Erkan(45)
- Zengin, Gokhan(40)
- Serdar, Osman(39)
- Kocabaş, Mehmet(37)
- Aslan, Naim(31)
- Baskonus, Haci Mehmet(31)
- Bulut, Hasan(31)
- Mete, Suleyman(31)
- Paksoy, Mehmet Yavuz(30)
- Kök, Mediha(27)
- Ince, Muharrem(26)
- Yildirim, Ozal(26)
- Özkul, İskender(26)
- Sulaiman, Tukur Abdulkadir(25)
- Topal, Murat(25)
- Guler, Omer(24)
- Serin, Faruk(23)
- Benzer, Fulya(22)
- Erten, Fusun(22)
- Alataş, Mevlüt(21)
- Güler, Seval Hale(21)
- Baykal, Duygu Sen(20)
- Taşgın, Yahya(20)
- Kutlu, Banu(19)
- Onat, Onur(19)
- Sahin, Kazim(19)
- Tanyol, Mehtap(19)
- Torğut, Gülben(19)
- Yildirim, Numan(19)
- Kahraman, Gökhan(18)
- Orhan, Cemal(18)
- Say, Yakup(18)
- Susam, Selim Orhun(18)
- Utku, Anıl(18)
Yayınlar
- MakaleAçık Erişim2023Scopus SJRQ2Modeling the electrical conductivity value of the model solution
Sabanci, Serdal; Kaya, Kübra; Göksu, Ali
The ohmic heating process is one of the novel electrical heating methods that are considered as fast, homogeneous and efficient heating. In this study, the details of the relationship between electrical conductivity (EC)-Temperature (Temp) and EC-pH-Temp at different Total Soluble Solid Content (TSSC) and different pH values were examined. Especially, the study explains details of the electrical conductivity value due to pH change (2, 2.5, 3, 3.5) and expressing EC change depending on the pH value of fruit and vegetable juices. At constant pH, EC values decrease with increasing TSSC values (10%, 20%, 30%, 40%, 50%, 60%) and decrease with increasing pH at constant TSSC value. When the relationship between Temp-EC is analyzed that the EC value increases as Temp increases in all cases and this increase is linear. It was found that the Temp-EC relationship was in high compatibility with an R2 value above 0.97. Also, in the Temp-EC-pH relationship, the R2 value was found to be an acceptable value above 0.95.
AtıfScopus4WoS3
İncele - MakaleYalnız künye2023Scopus SJRQ3Green Synthesis and Encapsulation of Superparamagnetic Magnetite for Mercury (II) Removal: Adsorption Isotherms, Adsorption Kinetics, and Thermodynamic Studies
Alp Kavlo, Hevidar; Ince, Muharrem; Kaplan Ince, Olcay; Aydogdu, Burcu; Ozcan, Cemile
Mercury (II) ions have significant ecological impacts. In the current study, magnetized iron oxide (Fe3O4) nanoparticles were green synthesized and encapsulated with alginate (ALG). The nanoparticles were converted into a composite (Fe3O4/ALG). The Fe3O4/ALG beads were used to remove Hg (II) from industrial wastewater. Characterization was performed by X-ray diffraction (XRD), scanning electron microscopy—energy dispersive spectroscopy (SEM-EDS), Fourier transform infrared spectroscopy (FT-IR), and thermogravimetric analysis-differential thermal analysis (TGA-DTA). A central composite design (CCD) approach was performed to define the experimental conditions providing the highest global adsorption efficiency and to optimize the pH, temperature and adsorbent mass. Hg (II) concentrations were determined by flame and electrothermal atomic absorption spectrometry (FAAS and ETAAS). The limits of detection (LOD) and quantification (LOQ) were 1.2 mg L−1 and 3.5 mg L−1 for FAAS and 0.2 µg L−1 and 0.5 µg L−1 for ETAAS, respectively. Additionally, Langmuir, Freundlich, and Temkin isotherm models were employed to determine the adsorption mechanism. The adsorption capacity of Fe3O4/ALG was determined to be 49.18 mg g−1 by the Langmuir model. Kinetic studies revealed that the adsorption of Hg (II) best fitted the pseudo-second order model. The Gibb’s free energy (ΔG°) values showed that the adsorption of Hg (II) on Fe3O4/ALG occurred spontaneously.
AtıfScopus8WoS8OpenAlex10İncele - MakaleYalnız künye2023Scopus SJRQ1Region Specific Ground-Motion Predictive Models for Shallow Active Regions
İçen, Abdullah; Sandikkaya, M. Abdullah
Using a global dataset, we propose a series of ground-motion predictive models for acceleration response spectra. The proposed models include regional adjustments to source, path, and site terms with nonlinear soil behavior. The regression coefficients are computed using linear and nonlinear mixed-effect regression algorithms. Furthermore, we develop heteroscedastic variability models for between-event, site-to-site, and single-site standard deviations. The between-event sigma model depends solely on magnitude, but the single-site standard deviation model depends on both magnitude and distance. Finally, the site-to-site standard deviation model is given in terms of VS30 and spectral acceleration at rock site condition.
AtıfScopus7WoS7OpenAlex9İncele - MakaleAçık Erişim2023Scopus SJRQ3Effect of glass sand used as aggregate on micro-concrete properties; [Učinak recikliranog stakla kao agregata na svojstva mikrobetona]
Etli, Serkan
Micro-concrete (MC) can be defined as a high-performance cement-based material produced using microaggregates and cement in the required proportions. Owing to its high performance, it has the potential to be used in the structural repairs of existing building elements. Within the scope of this study, an evaluation was conducted by creating a usage scenario under which glass, which is a waste product, can be reduced and applied in a way that provides a sufficient MC performance. There are four different binder contents in the mixtures within the scope of the present study, i.e., 570, 580, 599, and 658 kg/m3. From these mixtures, together with the control mixture, 12 %, 27 %, and 50 % microaggregates were replaced with glass sand and 16 different mixtures with a total of 4 different aggregate contents were produced. For the mechanical, physical, and durability tests, 40 × 40 × 160 mm sized prisms and 50 × 50 × 50 mm sized cubes were produced. For the purposes of this research, mechanical tests were carried out on 144 7-, 28- and 56-day old prismatic specimens. In addition, the effects of a freeze-thaw and temperature on the mechanical properties were investigated on 192 prismatic samples. In determination of the durability, physical properties such as the porosity, sorptivity, and specific gravity were tested and determined using cubic samples. The test results show that the replacement of MA with GS has positive effects on all mechanical behaviours of MC.
AtıfScopus7OpenAlex12İncele - MakaleAçık Erişim2023Scopus SJRQ3Seasonal changes in fatty acid profile of the freshwater snail Viviparus contectus (Millet, 1813) from lake habitat
Özçiçek, Esin; Kutluyer Kocabaş, Filiz; Kocabaş, Mehmet; Yilmaz, Ökkeş
The freshwater snail, Viviparus contectus, is an important shellfish owing to its nutritional composition (i.e., high amounts of protein, essential amino acids, fatty acid profile and minerals) and its promise as a candidate for the treatment of some diseases in traditional medicine. Hence, the seasonal changes in the fatty acid (FA) profile of Viviparus contectus caught from Demirköprü Dam Lake were determined in this study. Saturated fatty acid (SFAs) (64.54–80.39% of total fatty acids) had the highest concentration followed by polyunsaturated fatty acids (PUFAs) (10.63–21.83%) and monounsaturated fatty acids (MUFAs) (6.57–10.13%). Stearic acid (C18:0) was the major SFA while arachidonic acid (C20:4 n−6) was the major PUFA. The season significantly affected the FA profile of V. contectus while no significant difference was determined between seasons with respect to tissue MUFAs levels. A higher level of total SFAs was detected during spring (80.39%) while a higher proportion of MUFAs was detected during the winter (10.13%). The total amounts of PUFAs were highest in winter (21.83%). Overall, V. contectus has nutritional value. However, V. contectus caught in autumn may be nutritionally the most valuable for human consumption due to higher eicosapentaenoic acid 20:5 n−3 and docosahexaenoic acid contents.
AtıfScopus3WoS1OpenAlex4İncele - MakaleAçık Erişim2023Scopus SJRQ2Effects of İnclined Plate in a Channel to Control Melting of PCM in a Body İnserted on the Bottom Wall
Öztop, H.F.; Bakır, E.; Selimefendigil, F.; Gür, M.; Coşanay, H.
A two-dimensional time-dependent computational analysis was carried out to examine the effects of inclined plate on melting time of Phase Change Material (PCM) filled square block on the bottom wall of a channel. Solution of the governing equations are performed by using finite volume method. The RT25HC material is chosen as PCM. The study is done for different parameters of inclination angle of the plate and Reynolds number. It is observed that the inclined plate can be used to control of melting time of PCM in a block as well as flow field and temperature distribution in the channel. Using of acceleration angle as θ = 110° accelerates the melting time of PCM inside the block. Thus, mass fraction rate increases 4 times with application of inclined thin plate.
AtıfScopus31WoS27OpenAlex29İncele - MakaleAçık Erişim2023Scopus SJRQ4The Assessment of Health Risk from Heavy Metals with Water Indices for Irrigation and the Portability of Munzur Stream: A Case Study of the Ovaclk Area (Ramsar Site), Türkiye
Kutlu, Banu; Sarlgül, Ali
Surface water samples from the area of Munzur Stream in Türkiye (a Ramsar site) were evaluated for their suitability for irrigation and drinking purposes using different water quality indices. The human health risks were assessed as well. The study was conducted over a period of 24 months from January 2019 to December 2021 by taking samples from nine stations every month in order to determine the water quality of Munzur Stream, located in Tunceli. According to the results, Munzur Stream is in good condition in terms of the quality of drinking water and irrigation water. The concentrations of heavy metals such as Cu, Ni, Fe and Hg were high, though the water quality parameter according to Türkiye Ministry of Forestry and Water Affairs Surface Water Quality Regulations (TSWQR) was significantly lower than the permitted limits. In Munzur Stream, the irrigation water for all stations was reported to be excellent, good and suitable in terms of SAR, Na% and MH, respectively. The principal component analysis data formed the four principal components, explaining 98.22% of the total variance. The sources of pollution in this area include the rock types of the basin, soil erosion, domestic waste water discharge and agricultural flow of inorganic fertilisers.
AtıfWoS1OpenAlex3İncele - MakaleYalnız künye2023Scopus SJRQ2Physicochemical Properties for Food Packaging and Toxicity Behaviors Against Healthy Cells of Environmentally Friendly Biocompatible Starch/Citric Acid/Polyvinyl Alcohol Biocomposite Films
Gürler, Nedim; Paşa, Salih; Erdoğan, Ömer; Cevik, Ozge
The current study focuses on the fabrication, characterization, and cytotoxic effects of polymeric biocomposite films composed of starch, various concentrations of citric acid (3%, 6%, and 9%), and polyvinyl alcohol. The cross-linked corn starch (S)-polyvinyl alcohol (P) biocomposite films are prepared by casting technique using glucose (G) and fructose (F) as plasticizers. The chemical structure of obtained films is characterized by Fourier transform infrared and x-ray diffraction. Physicochemical parameters of the films such as solubility, swelling capacity, and water vapor permeability, optical and mechanical properties are investigated. Furthermore, the cytotoxicity is evaluated to determine the biocompatibility of samples. The physicochemical properties of S-P(Starch-Polyvinyl alcohol) films improve with the addition of citric acid during the esterification reaction. The tensile strength for Starch-Polyvinyl alcohol-Glucose blend composition with 3% citric acid (SPG3) and Starch-Polyvinyl alcohol-Fructose blend composition with 3% citric acid (SFG3) biocomposite films is determined as 10.17 and 8.24 MPa, respectively, compared to 8.16 and 7.94 MPa for without citric acid, respectively. The cell viability values of biocomposite films towards NIH-3T3 and L929 cells are calculated 90% compared to the control group. Thus, it demonstrates that they are also quite biocompatible materials.
AtıfScopus34WoS37OpenAlex37İncele - MakaleAçık Erişim2023Scopus SJRQ3Structural, physical, and radiation absorption properties of a significant nuclear power plant component: A comparison between REX-734 and 316L SS austenitic stainless steels
Say, Yakup; Güler, Ömer; Kavaz, Esra; ALMisned, Ghada; Ene, Antoaneta; Tekin, Huseyin Ozan
Austenitic stainless steels (SSs) are commonly used as in-core and surrounding structural materials in today’s industrial BWR and PWR systems. Such adaptable steels have also been the primary materials studied and used in several advanced nuclear reactor technologies, such as fast breeding and magnetic fusion reactors. In this study, some critical material properties, such as structural, physical, and radiation-shielding properties of REX-734 and 316L SS, were experimentally evaluated and compared to those of a number of other alloys. In addition to homogeneous element distribution, both alloys exhibit strong crystal orientation. The REX-734 alloy has a tensile strength of 1,259 MPa, whereas the 316L SS alloy has a tensile strength of 495 MPa. Moreover, nitrogen in the REX-734 alloy formed ultra-hard nitrides with Cr, Nb, and Si and precipitated into the structure and increased the strength. According to our findings, the mass attenuation coefficient values of the 316L SS sample were slightly higher than those of the REX-734 sample at all energies. It can be concluded that the REX-734 sample, with its exceptional strength qualities and excellent radiation attenuation capabilities, may be a viable nuclear power plant material for future investigations.
AtıfScopus7İncele - MakaleYalnız künye2023Scopus SJRQ2Analysis of awareness of gynaecological cancers İn women using social media
Alp Dal, Nursel; Gümüşsoy, Süreyya; Ertem, Gül
This study aimed to use social media to investigate the relationship between the demographic, obstetric and gynaecological characteristics and the awareness of gynaecological cancer among women. The data were collected between 1st March and May 2018 using an internet-baseline survey/surveymonkey/google form. The sample was consisted of 1227 women who were literate, active social media users and had volunteered to participate in the study via social media. The GCAS scores of women who were in the age range 20–24 years, primary school graduates, no social security, were not pregnant, had a miscarriage, did not examine their external genital organs, had not entered the menopause and who did not use any family planning methods, were lower than the other women. The GCA of the women was found to be high.
AtıfScopus3WoS2OpenAlex5İncele - MakaleAçık Erişim2023Scopus SJRQ3Investigation of thermophysical properties of synthesized SA and nano-alumina reinforced polyester composites
Şahal, Hakan; Aydoğmuş, Ercan; Arslanoğlu, Hasan
Synthesis and characterization of 4-[(E)-(5-bromo-2-hydroxybenzylidene) amino]-N-(4-methylpyrimidin-2-yl) benzenesulfonamide (SA) has been performed. Alumina (Al2O3) and SA reinforced polyester composites are synthesized, and characterization processes are carried out. SA formed has been characterized by Fourier transform infrared (FTIR) spektrofotometre and nuclear magnetic resonance (NMR) spectroscopy. The thermal decomposition behavior of the nanocomposites in a nitrogen environment under non-isothermal conditions from 298 to 973 K is investigated with proportional-integral-derivative (PID) system. Thermal conductivity, Shore D hardness, and thermal decomposition behaviors of the nanocomposites that are added with alumina filler and synthesized with SA reinforcement have been compared. Nano-alumina filler raises the thermal conductivity coefficient and Shore D hardness of the polyester composites. The addition of synthesized SA reduces both the thermal conductivity coefficient and Shore D hardness. The thermal conductivity coefficient has been measured at the lowest in the pure polyester (0.056 W/m·K), and highest in the nano-alumina reinforced composite (0.072 W/m·K). The lowest Shore D hardness (nearly 68) is determined in the synthesized SA reinforced composite. Also, the experimental study has been optimized with the help of response surface methodology (RSM), and the improved theoretical models have been evaluated by statistical analysis.
AtıfScopus5WoS6OpenAlex13İncele - MakaleYayıncıda açık erişim2023Scopus SJRQ4Family Physician’s Opinions and Recommendations on the Family Medicine Practices
Baş, Kazım
Objectives: This study aims to evaluate the opinions and recommendations of family physicians working in family health centers regarding the practices of family medicine. Methods: This descriptive research was conducted with 307 family physicians working in family health centers of Elazığ and Muş provinces located in the east of Turkey between September and November 2021. The sample of this study was comprised of 193 (62.9%) family physicians who were available during the study period. The questionnaire created by the researcher was used to collect with the face-to-face interview technique and/or Google Forms data. Results: A total of 193 family physicians were included in the study. The mean age of the family physicians was 41.4±8.5 years, and their mean population was 3138.1±534.1 people. Of the family physicians, 184 (95.3%) stated professional devaluation, 179 (92.7%) excessive workload, the problems arising from the legislation, 173 (89.6%) performance, 158 (81.9%) the excess of the population to be served, 155 (80.3%) financial problems, coordination problems with senior management, 132 (68.4%) inadequate with the physical structure of the building and equipment, and 125 (64.8%) stated the insufficient number of non-physician personnel were among the factors negatively affecting work in family health centers. In addition, 180 (93.2%) family physicians stated that changes are needed in existing family medicine practices. Conclusion: According to the study results, there are negative situations that affect the effective and efficient implementation of family medicine practices. The current policy needs to be revised to carry out family medicine practices effectively and efficiently.
AtıfScopus2OpenAlex2TR Dizin2
İncele - MakaleYalnız künye2023Scopus SJRQ1Mathematical modeling of vibration failure caused by balancing effect in hydraulic turbines
Kahraman, Gökhan; Özdemir, Osman
This article discusses the causes of vibrations depending on unbalanced hydraulic forces in rotating and non-rotating equipment in hydraulic plants within the scope of vibration measurement standards. The radial and axial positions of the turbine shaft, normal operating conditions, the absolute vibration of the signal output velocity during startup and shutdown during unbalance condition of the turbine, the proximity probes have been measured by TMO 793 accelerometer sensor and TMO 793 velocity sensor. The results obtained from the monitoring are analyzed and the first discussion is over the comparison of the current operating levels and vibration standards. Secondly, the comparison is analyzed in order to examine the improvement in vibration level of the elimination of hydraulic imbalance more comprehensively, considering the stability of the hydro turbine-generator unit, a proportional row damping force, proportional-order oil-film force and a hydraulic force and by creating a new non-linear proportional-order mathematical model. Changes in vibration levels and spectral bands for failure types are stated as well. The solution of this integrated and accurate mathematical model shows that it is useful and concise in the diagnosis and prediction of faults in hydropower plants.
AtıfScopus13WoS13OpenAlex16İncele - MakaleYayıncıda açık erişim2023Scopus SJRQ3Potassium chloride recovery from mechanically activated microcline through the chlorination roasting and leaching route
Alyosif, Bahaa; Uysal, Turan; Erdemoğlu, Murat
In this study, effects of mechanical activation in the chlorination roasting and water leaching route known as CaCl2 process and developed for the production of potassium chloride (KCl) from potassium feldspar ores were studied. A microcline containing K-feldspar ore with 10.89% K2O was first intensively dry milled by a planetary ball mill and mixed with calcium chloride (CaCl2) and then roasted at temperatures up to 1000 °C to obtain KCl that will be finally dissolved by the water leaching. Potassium recovery by water leaching increased rapidly up to 800 °C. At higher temperatures, the recovery decreased fast due to the evaporation of KCl. According to the K recovery values per unit energy consumed, the optimum roasting temperature was determined as 750 °C and the milling time was 15 min. It was concluded that intensive milling causes mechanical activation of the microcline to reduce the chlorination roasting temperature, which triggers a rise in the K recovery by the water leaching.
AtıfScopus9WoS8OpenAlex7İncele - MakaleYalnız künye2023Scopus SJRQ4Relationship between loneliness, hopelessness and social support experienced by mothers with disabled children
Baş, Nazan Gürarslan; Karatay, Gülnaz; Baş, Kazım
The aim of the study was to evaluate the relationship between loneliness, hopelessness and social support experienced by mothers with disabled children. This cross-sectional study was conducted with 106 mothers with disabled children. The data was collected by compiling the Personal Information Form and by applying three main scales: the UCLA Loneliness Scale (UCLA-LS), the Beck Hopelessness Scale (BHS) and the Multidimensional Scale of Perceived Social Support (MSPSS). The data obtained was analyzed using the number, percentage, mean, correlation, T test, Anova and Mann Whitney U tests. The UCLA-LS mean score of the mothers was 50.56 ± 11.94, the BHS mean score was 10.78 ± 4.93 and the MSPSS mean score was 40.97 ± 13.86. The results showed a positive correlation between the mean scores of the loneliness and hopelessness scale, and a negative correlation between the mean scores of the loneliness and hopelessness scale and the mean MSPSS score (p <.05). As a result of the research findings, mothers with disabled children experienced loneliness and hopelessness and did not receive sufficient social support.
AtıfScopus2WoS2İncele - BildiriYalnız künye2023Investigation of corrosion behavior of ZrN-based PVD coatings on Ti-29Nb-13Ta-4.6Zr alloy in Hank's solution
Ali, Leila Ait; Aslan, Naim; Yilmazer, Hakan; Niinomi, Mitsuo; Sen, Anil; Dikici, Burak; Benhala, B.; Raihani, A.; Mansouri, K.; Qbadou, M.
In this study, the TiNbTaZr (TNTZ) alloys, which do not contain toxic and allergic elements, have been coated with hard ZrN physical vapor deposition (PVD) coatings to increase their in-vitro corrosion resistance. In-vitro electrochemical behavior of the ZrN coating and uncoated TNTZ alloy was evaluated using open circuit potential (OCP) and potentiodynamic polarization (PDS) techniques, respectively. The characterizations of the coatings were carried out using scanning electron microscopy (SEM), energy dispersion spectroscopy (EDS), and X-ray diffraction (XRD). The SEM examinations showed that ZrN coating is homogeneous. Besides, ZrN coating had a higher corrosion resistance than uncoated TNTZ alloy in Hank's solution.
- MakaleAçık Erişim2023Scopus SJRQ3The effect of different boron compounds on nutrient digestibility, intestinal nutrient transporters, and liver lipid metabolism
Şahin, Emre; Orhan, Cemal; Erten, Füsun; Şahin, Fikrettin; Şahin, Nurhan; Şahin, Kazim
Background/aim: Gastrointestinal health is essential for maintaining a healthy lifestyle. Improving nutrient absorption and energy metabolism are the critical targets for intestinal health. This study aimed to determine the effects of different boron (B) derivatives on nutrient digestibility, intestinal nutrient transporters, and lipid metabolism in rats. Materials and methods: Twenty-one rats were allocated to three groups (n = 7) as follows: (i) Control, (ii) Sodium pentaborate pentahy-drate (SPP), and (iii) boric acid (BA). The rats were fed a chow diet (AIN-93M) and supplemented with 8 mg/kg elemental B from SPP (45.2 mg/kg BW) and BA (42.7 mg/kg BW) via oral gavage every other day for 12 weeks. The nutrient digestibility of rats in each group was measured using the indigestible indicator (chromium oxide, Cr2 O3, 0.20%). At the end of the experiment, animals were decapitated by cervical dislocation and jejunum, and liver samples were taken from each animal. The nutrient transporters and lipid-regulated transcription factors were determined by RT-PCR. Results: The nutrient digestibility (except for ash) was increased by SPP and BA supplementation (p < 0.05). SPP and BA-supplemented rats had higher jejunal glucose transporter 1 (GLUT1), GLUT2, GLUT5, sodium-dependent glucose transporter 1 (SGLT1), fatty acid transport protein-1 (FATP1), and FATP4 mRNA expression levels compared to nonsupplemented rats (p < 0.0001). BA-supplemented rats had remarkably higher peroxisome proliferator-activated receptor gamma (PPARγ) levels than nonsupplemented rats (p < 0.0001). In contrast, sterol regulatory element-binding protein 1c (SREBP-1c), liver X receptor alpha (LxR-α), and fatty acid synthase (FAS) levels decreased by SPP supplementation compared to other groups (p < 0.05). Conclusion: SPP and BA administration enhanced nutrient digestibility, intestinal nutrient transporters, and liver lipid metabolism in rats.
AtıfScopus8WoS7OpenAlex9TR Dizin1İncele - MakaleAçık Erişim2023Scopus SJRQ2Expression of phoenixin-14 and nesfatin-1 in the hypothalamo–pituitary–gonadal axis in the phases of the estrous cycle
Parlak Ak, Tuba; Yaman, Mine; Bayrakdar, Ali; Bulmus, Ozgur
Phoenixin-14 (PNX-14) and nucleobindin 2 (NUCB2)/nesfatin-1 are regulatory neuropeptides expressed in the hypothalamus. These neuropeptides can be effective in hormonal regulation of the hypothalamo–pituitary–gonadal (HPG) axis and reproductive functions. In the present study, the distribution of PNX-14 and NUCB2/nesfatin-1 in the hypothalamus, pituitary, ovary, and uterus tissues during the phases of the estrous cycle in female rats was investigated. Eighteen Wistar Albino rats determined among animals showing regular estrous cycle by vaginal smear method were divided into three groups: proestrus (Group I), estrus (Group II) and diestrus (Group III). Serum gonadotropin-releasing hormone (GnRH), plasma PNX-14, and NUCB2/nesfatin-1 concentrations were the highest, moderate, and lowest in estrus, diestrus, and proestrus phases, respectively. PNX-14 immunoreactivity in the supraoptic and arcuate nuclei of the hypothalamus and NUCB2/nesfatin-1 immunoreactivity in the paraventricular nuclei were particularly evident in the estrus phase. These neuropeptide immunoreactivities were decreased in different cells of anterior pituitary during proestrus compared with those during estrus and diestrus. PNX-14 immunoreactivity in the ovary, especially during the estrus phase, was diffuse and intense in the granulosa and luteal cells and oocytes, and it was few and weak in theca cells. In addition, NUCB2/nesfatin-1 immunoreactivity was abundant and strong in granulosa and luteal cells, theca and interstitial cells, and oocytes during estrus. In the estrus phase, PNX-14 immunoreactivity was strong in the glandular epithelial cells and stromal cells of the endometrium, also NUCB2/nesfatin-1 immunoreactivity was strong in the epithelial and glandular epithelial cells. As a result, when the estrous cycle was evaluated, it was concluded that the changes in the distribution of PNX-14 and NUCB2/nesfatin-1 at all phases were related to GnRH and that these neuropeptides showed the highest immunoreactivity especially in the HPG axis and uterus tissues of estrus rats.
AtıfScopus21OpenAlex22İncele - MakaleYalnız künye2023Scopus SJRQ2A novel electrochemical sensor for metoprolol analysis based on glutardialdehyde–zinc oxide modified boron doped diamond electrode
Koçak, Berna; İpek, Yeliz; Keçeci, Ali
In this study, glutardialdehyde–zinc oxide modified boron doped diamond electrode (GA2–ZnO/BDDE) was developed as a new electrochemical sensor for the rapid, sensitive and selective determination of metoprolol (MTP). By using boron doped diamond electrode (BDDE), glutardialdehyde modified boron doped diamond electrode (GA2/BDDE) and glutardialdehyde–zinc oxide modified boron doped diamond electrode (GA2–ZnO/BDDE) separately, the electrochemical behavior of MTP on the surfaces of these electrodes was determined by applying cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. According to the results, the linear working range was 9.99 × 10−7–3.85 × 10−5 mol·L−1 and the limit of detection (LOD) was 7.53 × 10−8 mol·L−1 in pH 7 Britton–Robinson buffer solution. In addition, intraday reproducibility of peak current and peak potential were measured on the GA2–ZnO/BDDE surface and the results were calculated as 0.56 and 1 (RSD%), respectively. In order to investigate the reproducibility of GA2–ZnO/BDDE, 5 different modified electrodes were prepared with the same composition and conditions. The interday repeatability of the modified electrode was calculated as 3.13 (RSD%) and 1.05 (RSD%) for interday peak current and peak potential, respectively. The applicability of this method was confirmed by analysis of commercial drug tablets containing MTP as active ingredient. The mean recovery of the developed sensor was 95.6 % ± 1.7.
AtıfScopus14WoS12OpenAlex13İncele - MakaleAçık Erişim2023Scopus SJRQ3Bioremediation of herbicide diquat dibromide from aqueous solution with white rot fungus Phanerochaete chrysosporium
Yildirim, Numan; Ciftci, Emine; Erguven, Gokhan Onder; Durmus, Barbaros
In this study, the fungal bioremediation of herbicide diquat dibromide (DD) by white rot fungus Phanerochaete chrysosporium was studied. After bioremediation, the reduction in toxicity of the remediated media was evaluated by Daphnia magna as a model organism. For bioremediation studies, flask-level batch experiments were performed at different DD concentrations (10, 20 and 50 ppm) under static and agitated conditions. The highest reduction rates of chemical oxygen demand and total organic carbon were determined as 85.92 (for 20 ppm DD) and 87.46% (for 10 ppm DD), respectively under agitated conditions. After bioremediation, D. magna bioassay was used for toxicity assessment during 24, 48 and 72-h periods. In current study, it was observed that P. chrysosporium has very effective bioremediation capacity for diquat dibromide. The D. magna bioassay revealed that P. chrysosporium provides effective reduction in toxicity of diquat dibromide.