Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Erten, Fusun(2)
- Akay, Mehmet(1)
- Aksoy Derya, Yeşim(1)
- Aybek, Hasan(1)
- Bozoğlu, Ömer(1)
- Doğan, Runida(1)
- Durmaz, Yadigar Çevik(1)
- Er, Besir(1)
- Gonenci, Ramazan(1)
- Güler, Osman(1)
- Gürarslan Baş, Nazan(1)
- Karadag, Abdullah(1)
- Karadağ, Ezgi(1)
- Karatay, Gülnaz(1)
- Kilig, Nazli(1)
- Kunduraci, Ersin(1)
- Kutlu, Banu(1)
- Kuzu, Ayşe(1)
- Küçükgül, Altuğ(1)
- Küçükgül, Azime(1)
- Oltuluoğlu, Hatice(1)
- Orhan, Ilksen(1)
- Otay, Tuba(1)
- Polat, Hilal Türkben(1)
- Sahin, Kazim(1)
- Türk, Ahmet(1)
- Uzun, Ela(1)
- Yüksekol, Özlem Doğan(1)
- Yılmaz, Ayşe Nur(1)
- Zencirci, Büşra(1)
- Çevik Durmaz, Yadigar(1)
- Önder, Eylem Yalçınkaya(1)
- Özay, Yusuf(1)
- Özsoy, Şule Yurdagül(1)
- Şakar, Hüseyin(1)
Yayınlar
- MakaleAçık Erişim2023Investigation of the Effects of Ghrelin and Kisspeptin Levels in Liver Tissue of Rats Fed with High Fructose Diet -A Histological Study
Özay, Yusuf; Güler, Osman; Türk, Ahmet; Karadag, Abdullah; Zencirci, Büşra
Purpose: High fructose corn syrup (HFCS) is used commonly in the food industry and has been associated with various diseases including obesity, diabetes and fatty liver. Ghrelin, an orexigenic hormone with widespread receptors in many tissues, exerts various central and peripheral effects. Food intake may reduce its synthesis. Kisspeptin plays a major role in reproductive hormones and its receptors are expressed in tissues with high metabolic activity, such as the liver. This study aims to investigate the effects of HFCS consumption on liver tissue and its relationship with Kisspeptin and Ghrelin levels. Materials and Methods: Fourteen adult male Wistar albino rats, aged eight to ten weeks, were used in this study and divided into two groups; Control and HFCS (n=7). Tumor Necrosis Factor-alpha (TNF-α), Ghrelin, and Kisspeptin levels in the liver tissues of the rats were measured using an immunohistochemical method and subsequently analyzed through histoscoring. Results: Our data revealed a significant increase in Kisspeptin, Caspase 3, and TNF-α levels and a decrease in Ghrelin levels in the HFCS group compared to the Control group. Conclusion: In conclusion, our study demonstrates, for the first time, changes in liver Kisspeptin levels induced by a high fructose diet. Furthermore, the consumption of HFCS in food led to inflammatory activation, tissue damage, and reduced Ghrelin levels.
- MakaleYalnız künye2022Fucus vesiculosus ve Laminaria digitata Ekstraktlarının \rProstat ve Seminal Vezikül p-PDE5, cGMP, eNOS ve ET-1 \rDüzeyleri Üzerine Etkileri
Sahin, Kazim; Er, Besir; Erten, Fusun
Üreme sağlığı yaşam kalitesinin önemli belirteçlerinden biridir. Günümüzde erkek bireylerde düşük \rlibido, erektil disfonksiyon, prematür ejakülasyon, gecikmiş veya inhibe orgazm gibi cinsel işlev \rbozuklukları giderek yaygın hale gelmektedir. Cinsel işlev bozukluklarının tedavisi için destek \rtedaviler arasında fito ve etnoterapiler günümüz dünyasında popülerlik kazanmaktadır. Fucus \rvesiculosus (FV) ve Laminaria digitata (LD), antioksidan, anti-tümör, antikoagülan, anti obezitik, \ranti inflamatuar, antiviral ve antibakteriyel aktivitelere sahiptirler. Bu çalışmanın amacı, FV ve LD\rekstraktlarının üzerine prostat ve seminal vezikül dokularında fosfodiesteraz tip 5 (p-PDE5), siklik \rguanozin monofosfat (cGMP), endotel nitrik oksit sentaz (eNOS) ve endotelin‑1 (ET-1) protein \rdüzeyleri üzerine etkilerini araştırmaktır. Çalışmada, toplam 21 adet erkek 12 haftalık SpragueDawley ırkı sıçan kullanıldı. Sıçanlar üç gruba ayrıldı: 1) Kontrol grubu, 2) FV grubu ve 3) LD \rgrubu. FV ve LD 300 mg/kg CA dozunda gavaj yoluyla 52 gün boyunca günlük olarak hayvanlara \rverildi. Prostat dokusunda kontrol grubuna göre, FV ve LD verilen gruplarda p-PDE5 (P<0.01), \rcGMP (P<0.001) ve eNOS (P<0.05) düzeylerinde artış gözlenirken, ET-1 (P<0.01) protein \rdüzeyinde düşüş tespit edildi. Benzer şekilde seminal vezikül dokusunda da p-PDE5 (P<0.001) ve \reNOS (P<0.001) artış, cGMP (P<0.01) ise sadece LD verilen grupta artış gözlendi. Seminal vezikül \rET-1 (P<0.001) düzeyinde ise prostat dokusuyla benzer şekilde düşüş görüldü. Sonuç olarak, FV\rve LD ekstraktlarının p-PDE5, cGMP ve eNOS, ET-1 sinyal yolaklarını regüle ederek cinsel işlev \rbozuklukları üzerine yararlı etkiler gösterebileceği düşünülmektedir.
- MakaleYalnız künye2022Effects of Maca Root Extract on Some Molecular Parameters of Kidney Tissue in Rats Fed a High-Fat Diet
Erten, Fusun
Maca (Lepidium meyenii) has been used as a dietary supplement in ethnomedicine for centuries.\rMaca has recently become a high-functional food globally, due to its numerous biological benefits.\rThe high-fat diet (HFD) is closely related to the occurrence of obesity. Obesity is a common cause\rfor chronic kidney disease. The aim of this study was to investigate the effects of maca on organic\ranion transporters-3 (OAT-3), organic cation transporter-1 (OCT-1), organic cation transporter-2\r(OCT-2), insulin receptor substrate-1(IRS-1), vascular adhesion molecule-1 (VCAM-1) and\rvascular endothelial growth factor (VEGF) protein levels. In the study, 28 Sprague-Dawley male\rrats were randomly allocated into four groups (n=7); i) Control group (fed with standard diet); ii)\rGroup fed with standard diet and supplemented with Maca (40mg/kg/day) group; iii) Group fed a\rHFD; iv) Group fed with Maca+HFD. After the 60-day of study, kidney OCT-1, OCT-2 and IRS-1\rprotein levels showed a significant increase in the HFD+Maca treated group compared to the HFD\rgroup (P<0.05). Renal OAT-3 level was found to be significantly lower in the HFD group compared\rto the control group (P<0.0001). In addition, a significant decrease in VCAM-1 and VEGF protein\rlevels was observed in the HFD+Maca group compared to the HFD group (P<0.0001). These\rresults show the protective and regulatory activity in the Maca's kidney tissue when both normally\rand the HFD diet is fed
- MakaleAçık Erişim2021Ebelik ve Hemşirelik Öğrencilerinin Covid 19 Salgını Hakkındaki Bilgileri ve Korunmaya Yönelik Aldıkları Önlemler
Orhan, Ilksen; Yılmaz, Ayşe Nur; Yüksekol, Özlem Doğan
Amaç: Bu araştırma ebelik ve hemşirelik öğrencilerinin Covid 19 ile ilgili bilgi düzeyleri ve korunmaya yönelik aldıkları önlemleri belirlemek amacıyla tanımlayıcı olarak yapıldı. Gereç ve Yöntemler: Araştırmanın evrenini bir ilin Sağlık Bilimleri Fakültesi Ebelik bölümünde okuyan 315 ve başka bir ilin hemşirelik bölümünde okuyan 200 öğrenci olmak üzere toplam 515 öğrenci oluştururken, araştırmanın örneklemini 395 öğrenci oluşturdu. Veriler 5-15 Mayıs tarihleri arasında, araştırmacılar tarafından hazırlanan anket formu ile online olarak toplandı. Araştırmada yüzde, frekans ve ki kare analizleri kullanıldı. Bulgular: Araştırmada öğrencilerin %90.09 oranında bilgi sahibi oldukları, %99’unun Covid 19 hastalığının belirtilerini doğru tanımladığı, %97.7’si hastalığı önlemek için alınabilecek tedbirleri doğru tanımladığı bulundu. Ayrıca öğrencilerin %93.66’sının korunma için çeşitli önlemler aldığı bulundu. Araştırmada Covid 19 virüsünün kuluçka süresi ortalama 4-14 gündür değişkenine doğru cevap verenler ile yanlış cevap verenler arasında okudukları bölümü isteyerek tercih etme ve okudukları bölümlere göre istatistiksel olarak anlamlı farklılık saptandı (p<0.05, Tablo 4). Önlem olarak yetkililerin yaptığı açıklamaları takip ettiklerini ve mümkün olduğunca bu önerilere uymaya çalıştıklarını ifade eden öğrenciler ile bu değişkene hayır cevabı veren öğrenciler arasında okudukları bölüme göre istatistiksel olarak anlamlı farklılık bulundu (p<0.05, Tablo 5). Sonuç: Öğrencilerin %66.6’sının Covid 19 ile ilgili tedavi konusunda yanlış bilgiye sahip oldukları saptandı. Ebelik ve hemşirelik bölümü öğrencilerine Covid 19 tedavisi konusunda eğitim verilmesi önerilebilir.Anahtar Kelimeler: Ebelik; Hemşirelik, Öğrenciler; Covid 19
AtıfOpenAlex6TR Dizin5
İncele - MakaleAçık Erişim2020Üniversite öğrencilerine verilen meme kanseri ve kendi kendine meme muayenesine yönelik eğitimin öğrencilerin kaygı düzeyine ve sağlık inançlarına etkisi
Durmaz, Yadigar Çevik; Doğan, Runida; Polat, Hilal Türkben; Uzun, Ela; Şakar, Hüseyin; Önder, Eylem Yalçınkaya
Amaç: Araştırmanın amacı meme kanseri ve kendi kendine meme muayenesi eğitiminin öğrencilerin kaygı seviyesi ve sağlıkinançları üzerine etkisini incelemektir.Yöntem: Bu çalışma tek grup öntest-sontest desenli, yarı deneysel türde bir çalışmadır. Örneklem seçiminde kolay ulaşılabilirdurum örneklemesi yöntemi kullanılmıştır. Araştırmanın evrenini Türkiye’nin Doğu Anadolu Bölgesi’nde bulunan bir devletüniversitesinin kız öğrencileri, örneklemini ise bu öğrencilerden araştırmaya katılmayı kabul edenler oluşturmuştur.Çalışmaya gönüllülük esasıyla toplamda 126 öğrenci katılmıştır. Veri toplama araçları olarak; “Kişisel Bilgi Formu”,“Champion’un Sağlık İnanç Modeli Ölçeği” ve “Hamilton Anksiyete Derecelendirme Ölçeği” kullanılmıştır.Bulgular: Öğrencilerin % 84.1’inin kendi sağlığını iyi olarak değerlendirdiği, % 93.7’sinin ailesinde meme kanseri olmadığıbelirlenmiştir. Eğitim sonrasında, öğrencilerin sağlık inançlarında gelişme görülürken, kaygı düzeylerinde azalma tespitedilmiştir. Sağlık İnanç Modeli Ölçeğinin alt boyut toplam puanları incelendiğinde, eğitim sonrasında, algılanan duyarlılık vealgılanan güven alt boyut puanlarının istatistiksel olarak anlamlı düzeyde arttığı, algılanan engel puanının istatistiksel olarakanlamlı düzeyde azaldığı görülmüştür (p˂0.05).Sonuç: Meme kanseri ve kendi kendine meme muayenesi eğitiminin öğrencilerin kaygı düzeyi ve sağlık inançları üzerinde etkiliolduğu belirlenmiştir. Eğitim sonrasında öğrencilerin kaygı düzeyinde düşme gözlenirken, sağlık inançlarının geliştiğibelirlenmiştir.
AtıfOpenAlex5TR Dizin2İncele - MakaleYalnız künye2020Determination of Effect of Working Conditions on Obsessive Compulsive Disorder and Anxiety in Midwives and Nurses
Çevik Durmaz, Yadigar; Kuzu, Ayşe; Kilig, Nazli
Aim: This study was carried out to determine the effect of certain characteristics of midwives and nurses for work life on obsessive-compulsive sign and anxiety levels. Materials and Methods: This is a descriptive study. The population of the study consisted of 157 midwives and nurses working in Tunceli State Hospital, Tunceli Dental Hospital and 3 Family Health Centers located in Center of Tunceli Data of the research was collected by Personal Information Form, Maudsley Obsessive Compulsive Questionnaire (MOCQ) and Beck Anxiety Inventory (BAI). For data evaluation, descriptive statistics, Mann-Whitney U test, KruskalWallis test, Spearman's correlation analysis were used. Results: The mean MOCQ score of midwives and nurses participating the study was 29.34 ± 6.01, their mean BAI score was 8.20±8.64. When MOCQ and BAI scores and sociodemographic data were compared, the difference in the gender variable was determined (p<0.05). A significant difference was found between MOCQ and BAI scores, according to the working positions and the presence of obsessive thoughts among family and colleagues. A significant difference was determined, between MOCQ scores according to the profession and BAI scores according to the weekly working hours (p>0.05). There wasn’t significant difference between the scales scores according to suitability of the profession. MOCQ and BAI scores were moderately and negatively correlated. Conclusion: The results of the study indicate that the obsessive-compulsive signs of midwives and nurses are high, their level of anxiety is moderate and these signs are affected by variables such as occupation, working position, weekly working hours.
AtıfTR Dizin3İncele - Proje2017Yersinia ruckeri ile Enfekte Gökkuşağı Alabalığı Makrofajlarında Ozonoterapinin Antiapoptotik Etkinliğinin Araştırılması
Otay, Tuba; Küçükgül, Altuğ; Küçükgül, Azime; Özsoy, Şule Yurdagül; Kutlu, Banu; Gonenci, Ramazan
Yersiniosis is a systemic disease caused by Yersinia ruckeri, which is particularly affecting Enteric red mite (ERM) disease in trout. There are still many issues regarding the mechanism of apoptosis and necrosis that play a role in the pathogen-host relationship in the disease. In the project, it was aimed to maintain the life of the cells and killing the bacteria by providing anti-apoptotic and anti-necrotic effect via application of therapeutic concentration of ozone to the macrophages infected with Y. ruckeri. In this study, the cells of the rainbow trout-originated cell line (RTS-11, mononuclear / macrophage) were exposed to the appropriate number of bacteria (Yersinia ruckeri, ATCC- 29473, serotype 1) for 24 hours after being incubated with ozonized medium (30 min) at the nontoxic concentration. For this purpose, effective concentrations of nontoxic ozone and bacteria were demonstrated by viability tests (3 Gamma, 1.5x108, respectively). After incubation times, the expression levels of caspases 1,3,8 and 12 were determined by realtime polymerase chain reaction and protein levels were investigated by ELISA method from the obtained lysates. In addition, apoptotic-necrotic cell ratios were determined in acridine orange and ethidium bromide staining in experimental groups. According to the findings, bacterial infection caused 47% loss of cells, while nontoxic ozone was found to protect the cells by 27%. Again, while bacterial infection increased apoptotic cells in different processes, ozone was found to significantly reduce this rate. At the same time, ozone suppressed the rate of necrosis caused by bacteria. It was also found that bacterial stimulation of caspases (1, 3, 8 and 12), which were effective in the initiation of apoptosis and necrotic processes and in the formation of cell loss, were suppressed by ozone pre-administration and mostly at the level of protein translation. According to the obtained data, Yersinia ruckeri infection caused cell loss in the macrophages of rainbow trout by stimulating both apoptosis and necrosis. However, nontoxic ozone significantly improved this negative situation. In this context, it has come to the conclusion that nontoxic ozone can be used as a safe and effective treatment alternative for increasing host defenses and eliminating the infection in the case of yersiniosis in fishes. However, in order for this argument to be fully understood, it is inevitable to support it with advanced molecular and in vivo studies.
- MakaleYalnız künye2016Postoperative Pain Management: Nursing Practices
Kunduraci, Ersin; Bozoğlu, Ömer; Akay, Mehmet; Aybek, Hasan; Karatay, Gülnaz; Gürarslan Baş, Nazan
Aim: The aim of the research was to evaluate the interventions of the nurses working in a state hospital for postoperative pain. Material and Methods: The data of this descriptive study was collected between March 9-13th, 2015. The sample of the study consisted of 99 nurses working in a state hospital. “The Pain Management in Postoperative Period Questionnaire” consisting of 24 questions was used for data collection. Data was analyzed by using SPSS database with numbers, percentages, and chi-square tests. Results: Less than half of the nurses (44.4%) had undergraduate level of education, 89.0% of them stated that nurses had responsibility in pain management, and 84.0% of them reported that they assessed the pain. The assessment of facial expression (39.3%), asking patients (27.4%), and pain scale applications (26.2%) were preferred mostly by nurses among pain assessment methods. Analgesic administration (50.5%), informing the physician (21.2%), and giving position (14.1%) were mostly preferred pain management methods respectively. Also, 96.0% of the nurses reported that the institution they work for did not have a pain management policy. Conclusion: According to the findings, the nurses employed in this state hospital did not have a standard practice for pain management
AtıfTR Dizin9İncele - MakaleYalnız künye2012Assessment of health status management in women with gestational diabetes
Aksoy Derya, Yeşim; Karadağ, Ezgi; Oltuluoğlu, Hatice
Objective: The aim of the study is to assess the health management in women with gestational diyabetes mellitus. Method: Designed as descriptive and crosssectional, the study was performed in the pregnancy clinic of a university hospital between 1st January and 31st August 2010. All patients applying to the clinic during the study with gestational diyabetes via oral glucose tolerance testing (n=149) constituted the universe of the study. Not using insulin, pregnant were included in the study that participating in the educational program at least for two months between the weeks 24 and 38 during their pregnancies. Totally 120 individuals were recruited, 60 as insulin-diet-exercise health management program, and 60 in only diet-exercise health management program. Findings: The mean age of the women were 32,8±5,1 and 47,5% were primary school graduates. Of the women, 80.8% were housewives. It was determined that the mean HbA1c (p=0,016) and postprandial blood glucose levels (p=0,034) of women in insulin-diet-exercise health management program were statistically and significantly lower and controlled than those in onlydiet-exercise health management program. The mean fasting blood glucose level was lower in those using insulin, but this score was statistically insignificant (p=0,131). The comparison of the two groups revealed that the rate of compliance with the diet (p=0,003) and exercise (p=0.269) programs prescribed was lower in those using insulin. Conclusion: Forming life style changes by involving women into health management programs effectively plays a key role in decreasing the negative effects of gestational diyabetes mellitus to the lowest levels for both the mothers and the newborns.
AtıfTR Dizin1İncele