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- MakaleAçık Erişim2026Scopus SJRQ2Cadmium-induced changes in haemato-immunological, oxidative stress and antioxidant parameters of Cyprinus carpio: Protective role of curcumin
Pala, Ayşegül; Eroğlu, Mücahit; Mişe Yonar, Serpil; İspir, Ünal; Yonar, Muhammet Enis
This study examined the adverse effects of sublethal concentrations of cadmium (Cd) and the potential of curcumin (CUR) to mitigate Cd-induced toxicity. We administered 1.5 and 3 mg/L of Cd and 100 mg/kg of CUR to fish (Cyprinus carpio) separately and in combination over 14 days. At the end of the experiments, various haematological and immunological parameters, oxidative stress levels and antioxidant parameters of fish were measured, and the differences between the groups were evaluated. Simultaneous CUR treatment with Cd reversed the changes in haematological parameters in fish, increased immune responses, reduced oxidative stress and normalized the impaired antioxidant enzyme activities. In summary, our study showed that dietary supplementation with CUR may be an effective strategy to reduce the toxic effects of Cd in carp.
- MakaleYalnız künye2014Scopus SJRQ1Effect of ellagic acid on some haematological, immunological and antioxidant parameters of rainbow trout (Oncorhynchus mykiss)
Yonar, S. Mise; Yonar, M. E.; Yöntürk, Y.; Pala, A.
In this study, effect of ellagic acid on some haematological, immunological and antioxidant parameters in the blood and various tissues of rainbow trout (Oncorhynchus mykiss) were examined. Four groups of rainbow trout were fed experimental diets containing either no ellagic acid (control) or supplemented with ellagic acid at 50mg/kg diet (EA-50), 100mg/kg diet (EA-100) or 150mg/kg diet (EA-150) for 21days. Samples of the blood and tissue (liver, kidney and spleen) were collected at the end of the experiment and analysed for their haematological profile (the red blood cell count, the haemoglobin concentration and the haematocrit level), immune response (the white blood cell count, the oxidative radical production (NBT activity), the total plasma protein and total immunoglobulin level) and oxidant/antioxidant status (the malondialdehyde level, the superoxide dismutase, catalase and glutathione peroxidase activity as well as the reduced glutathione concentration). The findings of this study demonstrated that ellagic acid had a positive effect on the haematological parameters, the immune response and the antioxidant enzyme activities of the fish.
AtıfWoS35OpenAlex37
İncele - MakaleYalnız künye2011Scopus SJRQ2Immunostimulating Effect of Levamisole on Spleen and Head-Kidney Leucocytes of Rainbow trout (Oncorhynchus mykiss, Walbaum 1792)
Seker, Engin; Ispir, Unal; Dörücü, Mustafa
An in vitro cultivation method for spleen and head kidney organ section were used to investigate the effects of levamisole on the immune response. After 10 days of culture with 10 mu g/ml, 50 mu g/ml and 100 mu g/ml or no levamisole in the culture media, the non specific defense reaction were measured by glass-adherent NBT (nitroblue tetrazolium) positive cells activation and phagocytic activity. Elevation in phagocytic activity was found for 10 mu g/ml and 50 mu g/ml levels of levamisole (P < 0.001), but no differences were found at levels of phagocytic activity in between 100 mu g/ml levamisole groups and control groups (P > 0.05). In the spleen and head kidney leucocytes, increased response to levamisole was shawn for all doses in the glass-adherent NBT positive cells activation.
AtıfWoS7İncele
