Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Susam, Selim Orhun(9)
- Alataş, M.(8)
- Ezer, T.(7)
- Gul, Muhammet(7)
- Batan, N.(6)
- Ellis, L.T.(6)
- Erata, H.(6)
- Hudaverdi, Burcu(6)
- Kocabaş, Mehmet(6)
- Topal, Murat(6)
- Öbek, Erdal(6)
- Arslan Topal, E. Işıl(5)
- Sen Baykal, Duygu(5)
- Serdar, Osman(5)
- Yeşiltepe, Akgün(5)
- ALMisned, Ghada(4)
- Celik, Erkan(4)
- Cikcikoglu Yildirim, Nuran(4)
- Czernyadjeva, I.V.(4)
- Graulich, A.(4)
- Güler, Ömer(4)
- Ince, Muharrem(4)
- Kučera, J.(4)
- Schäfer-Verwimp, A.(4)
- Afonina, O.M.(3)
- Aksu, Önder(3)
- Alkarrani, Hessa(3)
- Almisned, Ghada(3)
- Boiko, M.(3)
- Cano, M.J.(3)
- Erzberger, P.(3)
- Fedosov, V.E.(3)
- Gradstein, S.R.(3)
- Kiebacher, T.(3)
- Kilic, Gokhan(3)
- Kutluyer, Filiz(3)
- Natcheva, R.(3)
- Ochyra, R.(3)
- Porley, R.D.(3)
- Sabovljević, M.S.(3)
Yayınlar
- MakaleYalnız künye2022Scopus SJRQ3Characterization of the antioxidant activity, total phenolic content, enzyme inhibition, and anticancer properties of Achillea millefolium L. (yarrow)
Karaaslan Ayhan, Nagihan; Karaaslan Tunc, Merve Goksin; Noma, Samir Abbas Ali; Kurucay, Ali; Ates, Burhan
The antioxidant activity, total phenolic content, enzyme inhibition, anticancer properties of Achillea millefolium L. (yarrow), which is generally consumed by humans as herbal tea, were investigated. Yarrow extracts were prepared with different extraction techniques and solvents and the optimum conditions were determined. When the antioxidant activity and total phenolic content results were evaluated, the best yield was obtained with ultrasound-assisted extraction for all solvents. Moreover, the yields from highest to lowest were methanol, water, and acetonitrile. The enzyme inhibition and anticancer of Achillea millefolium L. extracts using methanol were evaluated. The IC50 values for the inhibition of xanthine oxidase and acetylcholinesterase were 4.974 ± 0.54 and 21.891 ± 1.118 µg/mL, respectively. The extract concentration was determined to be 23.85 μg/mL for 50% reduction in growth inhibitory activity cell viability (IC50) against breast cancer (MCF-7).
AtıfScopus7OpenAlex9
İncele - MakaleYalnız künye2021Scopus SJRQ2Homoploid hybrids of Origanum (Lamiaceae) in Turkey: morphological and molecular evidence for a new hybrid
Arabaci, Turan; Çelenk, Sevcan; Özcan, Taner; Martin, Esra; Yazici, Türker; Açar, Mikail; Üzel, Devrim; Dirmenci, Tuncay
In this study, three hybrids of Origanum (Lamiaceae) were examined in detail using morphological, karyological, palynological and molecular approaches. One of the three hybrids, O. × aytacii, is here described for the first time, and is compared with its putative parents, O. sipyleum and O. vulgare subsp. hirtum. In addition to morphological, karyological and palynological features, we also examined nuclear ribosomal DNA (ITS) sequences of O. × intermedium (O. onites × O. sipyleum), O. × intercedens (O. onites × O. vulgare subsp. hirtum) and their purported parental species that share the same area with the new hybrid. Pollen grains were hexacolpate and isopolar. The range of Polar/Equatorial ratio (P/E) of pollen for investigated taxa varied from 0.74 to 0.99. All investigated taxa are diploid with a chromosome number as 2n = 30. According to molecular results, O. × aytacii was the most polymorphic taxon. In addition, DNA sequences showed that O. × intercedens was more similar to O. vulgare subsp. hirtum than to O. onites, and O. × intermedium was more similar to O. onites than to O. sipyleum. Furthermore, O. onites and O. vulgare subsp. hirtum have many different ITS haplotypes, probably resulting from backcrossing with different individuals. Results obtained in this study demonstrate that hybridization has played a major role in the process of Origanum speciation.
AtıfScopus21OpenAlex18İncele - MakaleAçık Erişim2021Scopus SJRQ2New national and regional bryophyte records, 67
Ellis, L.T.; Alataş, M.; Álvaro Alba, W.R.; Charry Giraldo, A.M.; Amatov, V.; Batan, N.; Becerra Infante, D.A.; Burghardt, M.; Czernyadjeva, I.V.; Yu. Kuzmina, E.
AtıfScopus19OpenAlex19İncele - MakaleYalnız künye2021Scopus SJRQ2New national and regional bryophyte records, 66
Ellis, L.T.; Alataş, M.; Aleffi, M.; Álvaro Alba, W.R.; Becerra Infante, D.A.; Cárdenas Espinosa, K.A.; Aziz, Md N.; Bakalin, V.A.; Bergamo Decarli, G.; Boiko, M.
AtıfScopus12OpenAlex16İncele - MakaleYalnız künye2021Determination of Antioxidant Capacity, Phenolic and Elemental Composition in Syriac (Mardin) Wines by using Chromatographic and Spectrophotometric Methods
Sanyurek, Nesrin Karaca; Ince, Olcay Kaplan; Aydogdu, Burcu; Ince, Muharrem
Free radicals are responsible for many health problems, especially oxidative stress-related diseases. With conscious nutrition and the use of natural antioxidants, it is now possible to cope with these diseases or minimize their effects. The aim of this study was to determine pH, total acidity, total SO2, free SO2, relative SO2, dry matter, density, alcohol content, reducing sugar, ash, CUPRAC, DPPH free radical scavenging capacity, total phenolic content, elemental composition, and some phenolic compounds of Syriac (Mardin) wines. Estimated daily intake (EDI), target hazard quotients (THQ), total target hazard quotients (TTHQ), and relative risk (RR) were calculated, to assess a health risk resulting from regular consumption of Syriac wines. The elements EDI values through consumption of wines were less than the recommended dietary allowance values. Obtained THQ values were less than 1. When the obtained results are compared with the levels set by regulatory authorities, the investigated wine consumption does not pose a toxicological risk based on EDI, THQ, TTHQ, and RR values. In addition, this study showed that the Syriac wine’s antioxidant capacities are high and rich in phenolic compounds and elements.
AtıfScopus1WoS1OpenAlex3İncele - MakaleYalnız künye2021Scopus SJRQ2The assessment of basic blue 41 textile dye decolorisation using the Fenton process: response surface methodology optimisation and toxicity evaluation
Tanyol, Mehtap; Cikcikoglu Yildirim, Nuran; Tatar, Sule; Serdar, Osman; Yildirim, Numan
The biochemical biomarkers (Catalase (CAT), glutathione s-transferase (GST), cytochrome P4501A1 (CYP1A1450) activities and glutathione (GSH), malondialdehyde (MDA) levels) of D. polymorpha exposed to the basic blue 41 (BB41) solutions for 24 and 96 h before and after the Fenton process (FTP) were evaluated to investigate the efficiency of the FTP. The optimum conditions for the removal of BB41 were set using central composite design (CCD), which is a response surface methodology (RSM) module in the Design-Expert® software. The optimal conditions were found to be 27.87 min, 3.49 mg/L, and 0.04 for reaction time, initial BB41 concentration, and Fe2+/H2O2 molar ratio, respectively, resulting in maximum (99%) removal efficiency. After FTP, the MDA and GSH levels decreased significantly during the 24 and 96 h. CAT activities were increased after treatment. No statistically significant changes were observed in the CYP1A1 levels after FTP. GST activities decreased during 24 h but increased during 96 h after FTP. CYP1A1450, catalase, GST activities and MDA, GSH levels of D. polymorpha are useful biomarkers to evaluate the efficiency of FTP. This study suggests that BB41 dye must be further treated after the FTP to minimise the ecotoxicological risk.
AtıfScopus8WoS6OpenAlex8İncele - MakaleAçık Erişim2021Scopus SJRQ3Determination of fatty acids in Allium tuncelianum (Tunceli garlic) by gas chromatography with flame ionization detection (GC–FID)
Ugur, Yilmaz; Karaaslan-Ayhan, Nagihan; Icen, M. Sina; Bicim, Tulin; Erdogan, Selim; Yaman, Mehmet
Garlic has an important place in daily nutrition. It is consumed by people because of its antimicrobial, antibacterial, and antioxidant properties, and it is also known to be good for many diseases. Along with these properties of garlic, its fatty acid content is also important. The goal of this study is to determine the fatty acids in Allium tuncelianum (Tunceli garlic), which grows naturally in Tunceli, Turkey, by gas chromatography with flame ionization detection (GC–FID). Fifteen of 37 fatty acids studied were detected in Allium tuncelianum, and the primary fatty acids in the sample extracts were determined to be the polyunsaturated fatty acid (PUFA) linoleic acid (C18:2n6c, 41.595%) and the monounsaturated fatty acid (MUFA) oleic acid (C18:1n9c, 33.302%). Small quantities of saturated fatty acids (SAFAs) were also present, including palmitic acid (C16:0, 11.739%), henoicosanoic acid (C21:0, 6.946%), and stearic acid (C18:0, 2.362%).
AtıfScopus12WoS8OpenAlex11İncele - MakaleAçık Erişim2021Scopus SJRQ3Determination of anthocyanins and anthocyanidins in the wild grape (Vitis sylvestris Gmelin) by high-performance liquid chromatography-diode array detection (HPLC-DAD)
Karaaslan-Ayhan, Nagihan; Yaman, Mehmet
The determination of anthocyanins and anthocyanidins in wild grapes (Vitis sylvestris Gmelin) from Tunceli-Turkey are reported together with the influence of the extraction conditions on the results. Representative sets of anthocyanins (delphinidin-3-o-glucoside, cyanidin-3-o-glucoside, pelargonidin-3-o-glucoside, malvidin-3-o-glucoside) and anthocyanidins (delphinidin, cyanidin, pelargonidin, malvidin) were simultaneously determined by high performance liquid chromatography with diode array detection (HPLC-DAD). The extraction conditions including the solvent type, extraction time and liquid:solid ratio (v:w) were optimized. The anthocyanin and anthocyanidin contents changed significantly depending on the extraction conditions. Malvidin-3-o-glucoside was identified to be the primary compound.
AtıfScopus10WoS8OpenAlex11İncele - MakaleYalnız künye2021Scopus SJRQ3Glyphosate disrupts sperm quality and induced DNA damage of rainbow trout (Oncorhynchus mykiss) sperm
Akça, Ayşe; Kocabaş, Mehmet; Kutluyer, Filiz
As a widespread pollutant, glyphosate (GLY) adversely affects the aquatic environment and can impair the reproductive ability and functions of fish. The purpose of the current study was to assess in vitro effect of GLY on rainbow trout (Oncorhynchus mykiss) sperm cells. The sperm cells were exposed to different GLY concentrations (2.5, 5, 10 mg/L). Sperm motility parameters were analyzed with computer assisted sperm analysis. DNA fragmentation (%) was measured by the comet assay using fluorescence microscopy. With increased GLY concentration, sperm motility and duration decreased after exposure. DNA fragmentation (% DNA in tail) in sperm cells was higher in treatments containing GLY than control (p < 0.05). Consequently, sperm cells are sensitive to low doses of GLY, and this can negatively affect natural populations.
AtıfScopus8WoS4OpenAlex5
İncele - MakaleAçık Erişim2021Scopus SJRQ1Investigation of perceived fear of COVID-19 and vaccine hesitancy in nursing students
Yeşiltepe, Akgün; Aslan, Sinan; Bulbuloglu, Semra
This study aims to investigate the perceived fear of COVID-19 and vaccine hesitancy in nursing students. This study was conducted as a cross-sectional study with the participation of 1167 nursing students. Personal Information Form, Vaccine Hesitancy Scale and Fear of COVID-19 Scale were used for data collection. The reasons for the vaccine hesitancy of the students were listed as follows: 57.6% of them stated that it had side effects, 17.7% stated there was no conclusive evidence that the vaccine was effective, and 12.6% stated it was not reliable. A positive correlation was found between fear of COVID-19 and vaccine hesitancy.
AtıfScopus19WoS19OpenAlex30İncele - MakaleAçık Erişim2020Scopus SJRQ2New national and regional bryophyte records, 63
Ellis, L.T.; Afonina, O.M.; Czernyadjeva, I.V.; Konoreva, L.A.; Potemkin, A.D.; Kotkova, V.M.; Alataş, M.; Blom, H.H.; Boiko, M.; Cabral, R.A.
AtıfScopus21OpenAlex23İncele - MakaleYalnız künye2020Scopus SJRQ1Emergency department network under disaster conditions: The case of possible major Istanbul earthquake
Gul, Muhammet; Fuat Guneri, Ali; Gunal, Murat M.
Emergency departments (EDs) provide health care services to people in need of urgent care. Their role is remarkable when extraordinary events that affect the public, such as earthquakes, occur. In this paper, we present a hybrid framework to evaluate earthquake preparedness of EDs in cities. Our hybrid framework uses artificial neural networks (ANNs) to estimate number of casualties and discrete event simulation (DES) to analyse the effect of surge in patient demand in EDs, after an earthquake happens. At the core of our framework, Earthquake Time Emergency Department Network Simulation Model (ET-EDNETSIM) resides which can simulate patient movements in a network of multiple and coordinated EDs. With the design of simulation experiments, different resource levels and sharing rules between EDs can be evaluated. We demonstrated our framework in a network of five EDs located in a region of which is estimated to have the highest injury rate after an earthquake in Istanbul, Turkey. Results of our study contributed to the planning for expected earthquake in Istanbul. Simulating a network of EDs extends the individual ED studies in the literature and furthermore, our hybrid framework can help increase earthquake preparedness in cities around the world. On the methodological side, the use of ANN, which is a member of machine learning (ML) algorithms family, in our hybrid framework also shows the close links between ML and DES.
AtıfScopus30WoS31OpenAlex40İncele - MakaleYalnız künye2020Scopus SJRQ2Application of Pythagorean fuzzy AHP and VIKOR methods in occupational health and safety risk assessment: the case of a gun and rifle barrel external surface oxidation and colouring unit
Gul, Muhammet
The field of occupational health and safety (OHS) focuses on reducing occupational accidents to an acceptable level. OHS covers systematic efforts aimed at providing employee health, safety and welfare in the workplace. This study proposes a new approach for risk assessment in the field of OHS. It integrates the Pythagorean fuzzy analytic hierarchy process (PFAHP) and fuzzy VlseKriterijumska Optimizacija I Kompromisno Resenje (FVIKOR) into a risk assessment process. The PFAHP is used in weighting the risk parameters. FVIKOR is then applied to prioritize the hazards. To demonstrate the applicability and validity of the proposed approach, a case study of a barrel external surface oxidation and colouring unit of a gun and rifle production facility is performed. A comparison is also provided between the proposed approach and an intuitionistic fuzzy sets-based approach. The proposed approach is found to produce reliable outcomes that better represent the vagueness of the decision-making process.
AtıfScopus99WoS100OpenAlex133İncele - MakaleYalnız künye2020Scopus SJRQ4Spermatologic characteristics and sperm motility alterations caused by short-term copper exposure in Brook Trout Salvelinus fontinalis
Kutluyer, Filiz; Kocabaş, Mehmet; Başçınar, Nadir
Spermatozoa movement in many aquatic animals with external fertilization is directly related to the external aqueous environment. In particular, environmental toxic metals can cause harmful effects and impair sperm cell functions. The high concentrations of copper (Cu) may be harmful for aquatic animals, while low levels are required for metabolic interactions. Herein, we investigated the effect of different copper concentration [0 mg L−1 (Control),.5 mg L−1, 1 mg L–1, and 2 mg L−1] on spermatozoa of brook trout Salvelinus fontinalis. Motility and survival of sperm cells were assessed. Our results indicated that Cu exposure caused to an evident decrease in motility and longevity of spermatozoa with increasing concentrations (p <.05). Overall, we showed that Cu exposure can impair sperm motility of S. fontinalis. Our study suggested that sperm motility has the potential to be a sensitive bioindicator of freshwater environmental pollution.
AtıfScopus3WoS3OpenAlex3İncele - MakaleYalnız künye2020Scopus SJRQ2Modeling and optimization of indigo carmine adsorption from aqueous solutions using a novel polymer adsorbent: RSM-CCD
Torğut, Gülben; Tanyol, Mehtap; Meşe, Zeynep
A novel adsorbent was prepared via the free radical copolymerization of 2-(dimethylamino) ethyl methacrylate (DMAEMA) and acrylonitrile (AN) using 2,2′-azobisizobutyronitrile (AIBN) as an initiator at 65 °C. Poly(DMAEMA-co-AN) was characterized by FT-IR, 1H-NMR, and SEM techniques. Its thermal properties were determined by TGA and DSC. The copolymer was used to remove indigo carmine (IC) from aqueous solutions. The optimum IC removal percentage was determined to be 99.53% with poly(DMAEMA-co-AN) of 0.10 g/100 mL, contact time of 31.37 min, 46.58 mg/L initial concentration of IC using a central composite design in response surface methodology. The high maximum adsorption capacity (196.07 mg/g) proved that poly(DMAEMA-co-AN) can be used as a promising adsorbent for the removal of IC from wastewaters.
AtıfScopus20WoS19OpenAlex21İncele - MakaleYalnız künye2020Scopus SJRQ2A multi-method patient arrival forecasting outline for hospital emergency departments
Yucesan, Melih; Gul, Muhammet; Celik, Erkan
Patient arrivals at the emergency department (ED) of hospitals has an unpredictable behavior. So that, adequate forecasting of this process can serve a management baseline to better allocate ED human resources and medical equipment. In this paper, a multi-method patient arrival forecasting outline for EDs is developed. The methods followed within this study include single methods as linear regression (LR), autoregressive integrated moving average (ARIMA), artificial neural network (ANN), exponential smoothing and hybrid methods as ARIMA–ANN and ARIMA-LR. As the subject of the study, a private hospital ED case in Turkey is carried out. Data of ED patient arrivals for the year of 2016 was used to set up models. Forecasting performance of the multi-method outline was measured using mean absolute percentage error. The ARIMA–ANN hybrid model is shown to outperform in terms of forecasting accuracy. In order to contribute to the current knowledge, this paper is a novel attempt of applying these methods to model ED patient arrivals and making an overall assessment among them. The results can be used to aid in strategic decision-making on ED staffing and scheduling policy planning in response to predictable arrival variations.
AtıfScopus29WoS26OpenAlex37İncele - MakaleYalnız künye2020Scopus SJRQ3Inhibitory effect of Tunceli garlic (Allium tuncelianum) on blastocystis subtype 3 grown in vitro
Aykur, Mehmet; Karakavuk, Emrah; Karakavuk, Muhammet; Akıl, Mesut; Can, Hüseyin; Döşkaya, Mert; Gürüz, Yüksel; Dağcı, Hande
Objective: Blastocystis is a common protozoan parasite detected worldwide. This study aims to investigate the in vitro inhibitory effect of ethyl alcohol extracts of Tunceli garlic (Allium tuncelianum) on growth of Blastocystis ST3 subtype. Methods: Blastocystis ST3 were grown in 3 ml Jones’s medium containing A. tuncelianum prepared at five different concentrations for 72 hours at 37°C. Distilled water was used as negative control whereas metronidazole (MTZ) and trimethoprim-sulfamethoxazole (TMP-SMX) prepared in 0.1, 0.5 and 1 mg/ml of concentrations was used as the positive control. Results: According to the results, the MIC90 of the A. tuncelianum was 115 mg/ml at 72 hours. MIC90 of MTZ was 1 mg/ml at 72 hours (94.96%). TMP-SMX had the highest growth MIC90 effect which was reached at 1 mg/ml concentration during 24 hours (88.18%). The growth inhibitory effect of A. tuncelianum extract increased gradually in all doses and timepoints. Conclusion: In this study, obtained findings show the potential inhibitory effect of A. tuncelianum plant extract against Blastocystis ST3 which causes symptomatic diarrhea in humans. It may be recommended to consume the whole A. tuncelianum plant as food supplement. A. tuncelianum extract could be considered as an alternative for the potential treatment of Blastocystis infection.
AtıfScopus6OpenAlex7İncele - MakaleYalnız künye2020Scopus SJRQ3A fuzzy-based occupational health and safety risk assessment framework and a case study in an international port authority
Gul, Muhammet
Ports are complex systems that play a crucial role in the transportation of maritime-related products and services. Since ports face various safety issues in design, installation, operation and maintenance processes, there are many aspects open for improvement in Occupational Health and Safety risk assessment and it is required to deal with risks, reduce them to an acceptable level and control. To struggle with emerging risks and manage this process better, a risk assessment framework is proposed for ports in this study. A case study is performed in a Turkish international port authority using the proposed framework. Fuzzy Analytic Hierarchy Process (FAHP), which is a commonly used fuzzy multi-criteria decision-making method, was used in weighting two risk factors: likelihood and severity. The orders of priority of hazards were then determined by a fuzzy-based VIKOR method based on the output of FAHP. The proposed framework overcomes some drawbacks, including a lack of assignment on the weight to two risk assessment factors and lack of the high dependence of the prioritisation on the experts’ opinions. To validate the results, a sensitivity analysis was conducted. In conclusion, the study contributes to the applicability of the proposed framework to assess the risks in ports and provides a distinct risk prioritisation.
AtıfScopus43WoS39OpenAlex49İncele - MakaleYalnız künye2019Scopus SJRQ2The usability of oxidative stress and detoxification biomarkers in Gammarus pulex for ecological risk assessment of textile dye methyl orange
Cikcikoglu Yildirim, Nuran; Yaman, Metin
The present study was undertaken to determine the toxicity of the methyl orange by using the changes of some antioxidant and detoxification enzyme activities in Gammarus pulex. Lethal Concentration (LC) value of Methyl Orange (MO) was determined. Three sublethal doses of MO (1/4; 1/8 and 1/16 of LC value) were exposed to G. pulex for 24 and 96 h. Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GSH-P X ), Cytochrome p450 (CYP1A1), Glutathione S-transferase (GST) activities as well as Glutathione (GSH) and Malondialdehyde (MDA) levels were determined by using The enzyme-linked immunosorbent assay (ELISA) kit. The CAT and CYP1A1 activities were decreased in all the groups exposed to different doses of MO. GST activity and GSH, MDA levels were increased all the groups exposed to different doses of MO. The GSH-P X activities were changed in all the groups. MO affected SOD activity at different levels and in different concentrations. In our study, it has been found that exposure duration didn’t significantly affect the biochemical biomarkers except for GST and GSH. In conclusion, alterations in antioxidant and detoxification enzymes and lipid peroxidation may potentially be used as sensitive biomarkers for risk assessment of dyes in the environment and may contribute to the establishment of discharge regulations.
AtıfScopus17WoS18OpenAlex18İncele - MakaleYalnız künye2019Scopus SJRQ2Modelling cadmium bioaccumulation in Gammarus pulex by using experimental design approach
Serdar, Osman; Pala, Aysegul; Ince, Muharrem; Onal, Ali
Recently, although dynamic approaches have been used increasingly to describe metal bioaccumulation in aquatic organisms, the validation of such laboratory-derived modelling is rarely assessed under environmental conditions. The present study aims to evaluate and verify statistical and mathematical models for the bioaccumulation of cadmium (Cd) and to evaluate the suitability of Gammarus pulex as a biomonitor for Cd. To optimise Cd2+ ion bioaccumulation conditions a Box–Behnken design was used and whether G. pulex can be used as an estimated tool to assess aquatic quality was investigated. A Box–Behnken experimental design combined with response surface modelling (RSM) was employed for Cd2+ bioaccumulation in G. pulex. Independent variables including temperature, contact time and Cd2+ ion concentration significance and their interactions were tested using analysis of variance. The selected variables’ optimum values were obtained by solving the quadratic regression model along with by analysing the response surface contour plots. Based on Box–Behnken design, the applied model is significant because model F-value and R2 were obtained as 5121.49, 0.9998, respectively. Bioaccumulation of Cd amount was analysed using electrothermal atomic absorption spectrophotometer. The obtained data suggest that G. pulex can be evaluated as Cd biomonitor.
AtıfScopus3WoS3OpenAlex6İncele