Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Attar, Rukset(7)
- Ozbey, Ulku(7)
- Farooqi, Ammad Ahmad(5)
- Ozcelik, Beraat(3)
- Butt, Ghazala(2)
- Lin, Xiukun(2)
- Romero, Mirna Azalea(2)
- Afshar, Behnaz(1)
- Alaaeddine, Nada(1)
- Aleksic, Ivana(1)
- Alhewairini, Saleh S(1)
- Alhewairini, Saleh S.(1)
- Aras, A.(1)
- Aras, Aliye(1)
- Arslan Topal, E. Işıl(1)
- Başpınar, Yasemin(1)
- Dilem Doğan, Şengül(1)
- Farooqi, A.A.(1)
- Farooqi, Ammad A.(1)
- Guo, Mingyue(1)
- Gözde Gündüz, Miyase(1)
- Gürbüz, Perihan(1)
- Hanna-Wakim, Lara(1)
- Khalid, S.(1)
- Lin, X.(1)
- Liu, Minghua(1)
- Malik, Durr-E-Shahwar(1)
- Malik, Durrshahwar(1)
- Nikodinovic-Runic, Jasmina(1)
- Nurmurzayevich, Sadykov B.(1)
- Ozbey, U.(1)
- Ozturk, Ozlem(1)
- Pimentel, Tatiana Colombo(1)
- Purenovic, Jelena(1)
- Qadir, Muhammad Imran(1)
- Qureshi, M.Z.(1)
- Qureshi, Muhammad Z.(1)
- Romero, M.A.(1)
- Romero, Mirna A.(1)
- Sabitaliyevich, Uteuliyev Y.(1)
Yayınlar
- MakaleAçık Erişim2025Scopus SJRQ3Gynaecological cancer awareness and healthy lifestyle behaviors of women aged 20-65 years: A descriptive cross-sectional study
Yaşar, Beril Nisa; Şeker, Sevda Arslan
For both individual and community health, women's health is vital. In particular, gynecological cancers can be prevented or treated by adopting healthy lifestyles, raising awareness, and detecting them early. This study aimed to identify levels of gynecological cancer awareness and healthy lifestyle behaviors among women aged 20-65 years. There were 251 women in the descriptive cross-sectional study. The Gynecological Cancers Awareness Scale (GCAS), the Descriptive Characteristics Form, and the Healthy Lifestyle Behavior Scale-II (HLBS-II) were used to gather data. The data was analyzed using the Pearson's correlation test, multiple linear regression, and descriptive statistics. The average HLBS-II score was 123.53±20.75, while the average GCAS score was 149.64±21.30. The HLBS-II and GCAS scores showed a statistically significant positive correlation. Women knowledgeable about early diagnosis methods scored 10.758 times higher on the GCAS, while women familiar with vulvar self-examination scored 11.016 times higher. Employed women had a mean HLBS-II score 6.124 times higher than non-employed women (p<0.05). Women's awareness of gynecological cancer was high, but they also had moderately good lifestyle choices. To raise awareness and promote healthy lifestyle choices, healthcare professionals are advised to take part in health-promoting initiatives.
AtıfScopus2WoS2OpenAlex2
İncele - MakaleAçık Erişim2024Scopus SJRQ2Is Cladophora fracta an efficient tool of accumulating critical raw materials from wastewater and there a potential health risk of use of algae as organic fertilizer?
Arslan Topal, E. Işıl; Öbek, Erdal; Topal, Murat
In this study investigation of accumulations of critical raw materials (cobalt (Co), antimony (Sb), vanadium (V), lanthanum (La) and tungsten (W)) from wastewater by using C. fracta were aimed. Besides, assessment of the potential health risks in terms of the use of organic fertilizer obtained from the macroalga to be harvested from the treatment were also aimed. Highest Co, Sb, V, La and W accumulations by algae in reactor were 125±6.2%, 201.25±10%, 318.18±15%, 357.97±18%, and 500±25%, respectively. When compared with control, Co, Sb, V, La and W in algae increased 2.25, 3.01, 4.18, 4.58, and 6 times, respectively. The algae was very high bioaccumulative for Co and La. Highest MPI was calculated as 3.94. Non-carcinogenic risk of CRMs according to different exposure types (ingestion, inhalation, and dermal) were calculated for man, woman and child. There is not any non-carcinogenic risk from the investigated exposure ways of algae as organic fertilizer.
AtıfScopus2WoS2OpenAlex2İncele - MakaleYalnız künye2023Scopus SJRQ2Investigation of Antimicrobial, Anti-Quorum Sensing, and Cytotoxic Activities of Flavonoids Isolated from Pulicaria armena Boiss. & Kotschy ex Boiss. (Asteraceae)
Başpınar, Yasemin; Gürbüz, Perihan; Dilem Doğan, Şengül; Gözde Gündüz, Miyase; Aleksic, Ivana; Vojnovic, Sandra; Nikodinovic-Runic, Jasmina; Yavuz Paksoy, Mehmet
This is the first report on the separation and biological assessment of all metabolites derived from Pulicaria armena (Asteraceae) which is an endemic species narrowly distributed in the eastern part of Turkey. The phytochemical analysis of P. armena resulted in the identification of one simple phenolic glucoside together with eight flavon and flavonol derivatives whose chemical structures were elucidated by NMR experiments and by the comparison of the spectral data with the relevant literature. The screening of all molecules for their antimicrobial, anti-quorum sensing, and cytotoxic activities revealed the biological potential of some of the isolated compounds. Additionally, quorum sensing inhibitory activity of quercetagetin 5,7,3’ trimethyl ether was supported by molecular docking studies in the active site of LasR which is the primary regulator of this cell-to-cell communication system in bacteria. Lastly, the critical molecular properties indicating drug-likeness of the compounds isolated from P. armena were predicted. As microbial infections can be a serious problem for cancer patients with compromised immune systems, this comprehensive phytochemical research on P. armena with its anti-quorum sensing and cytotoxic compounds can provide a new approach to the treatment.
AtıfScopus1OpenAlex1İncele - Derleme MakaleAçık Erişim2022Scopus SJRQ4Multifunctional role of Nobiletin in cancer chemoprevention
Malik, Durr-E-Shahwar; Attar, Rukset; Ozbey, Ulku; Romero, Mirna Azalea; Yulaevna, Ishmuratova Margarita; Purenovic, Jelena
The diversity of highly bioactive and pharmacologically active natural products which recognize essential biological targets having exquisite specificity, constitutes a massive pharmacological database for discovery of valuable drugs. The rapid accumulation of information has revealed chemopreventive role of nobiletin against wide variety of cancers. Recent efforts are now being expanded and new integrative omics technologies have illuminated continuously upgrading list of molecular mechanisms which underlie carcinogenesis and metastasis. In this mini-review, we explore the progress that has been made in the identification of promising molecular targets of nobiletin.
AtıfScopus5OpenAlex4İncele - Kitap BölümüYalnız künye2022Metastasis inhibitory role of blueberries: time to play gooseberry with oncogenic cascades and metastasis
Farooqi, Ammad Ahmad; Ozbey, Ulku; Pimentel, Tatiana Colombo; Attar, Rukset
The magical little fruits have started to gain attention because of their cancer chemopreventive roles against different cancers. More recently, cancer inhibitory properties of blueberry extracts and isolated bioactive constituents have been described that provide new mechanistic insights. However, there are visible knowledge gaps in our understanding about metastasis inhibitory role of blueberries in xenografted mice. Despite mainstream popularization of cancer chemopreventive role of blueberries, many questions remain about their precise role in the regulation of deregulated oncogenic cascades in metastasis. It will be really exciting to consider how new scientific breakthroughs in future might propel the science of nutrigenomics to a more sophisticated level of inquiry.
AtıfScopus2OpenAlex1İncele - MakaleAçık Erişim2021Scopus SJRQ4Regulation of cell signaling pathways by Wogonin in different cancers: Mechanistic review
Butt, Ghazala; Ozbey, Ulku; Malik, Durrshahwar; Attar, Rukset; Youssef, Lara; Farooqi, Ammad Ahmad
Natural products have historically been invaluable as a premium source of therapeutic agents. Recent advancements in genomics and structural biology have portrayed a high-resolution landscape of the diversity of proteins targeted by pharmacologically active products from natural sources. Natural product research has generated valuable wealth of information and cutting-edge research-works have leveraged our conceptual knowledge altogether to a new level. Wogonin (5,7-dihydroxy-8-methoxyflavone) is an O-methylated flavone and has attracted noteworthy appreciation because of its ability to pharmacologically target plethora of cell signaling pathways in different cancers. In this mini-review, we have gathered scattered pieces of available scientific evidence to summarize how wogonin pharmaceutically targeted Wnt/β-catenin, JAK/STAT, VEGF/VEGFR and TRAIL-driven apoptotic pathways in wide variety of cancers. We have also critically analyzed how wogonin prevented carcinogenesis and metastasis in tumor-bearing mice. Although researchers have uncovered pleiotropic role of wogonin in the regulation of different oncogenic signaling cascades but there are visible knowledge gaps in our understanding related to regulation of non-coding RNAs by wogonin. Future studies must converge on the unraveling of additional drug targets for wogonin to achieve a fuller and realistic understanding of the chemopreventive properties of wogonin.
AtıfScopus5WoS6İncele - MakaleYalnız künye2019Scopus SJRQ2Regulation of signaling pathways by β-elemene in cancer progression and metastasis
Qureshi, Muhammad Z.; Attar, Rukset; Romero, Mirna A.; Sabitaliyevich, Uteuliyev Y.; Nurmurzayevich, Sadykov B.; Ozturk, Ozlem; Wakim, Lara H.; Lin, Xiukun; Ozbey, Ulku; Yelekenova, Armida Bakhytbekovna
Entry of β-elemene into various phases of clinical trials advocates its significance as a premium candidate likely to gain access to mainstream medicine. Based on the insights gleaned from decades of research, it seems increasingly transparent that β-elemene has shown significant ability to modulate multiple cell signaling pathways in different cancers. We partition this multicomponent review into how β-elemene strategically modulates various signal transduction cascades. We have individually summarized regulation of tumor necrosis factor related apoptosis-inducing ligand, signal transducers and activators of transcription, transforming growth factor/SMAD, NOTCH, and mammalian target of rapamycin pathways by β-elemene. Last, we will discuss the results of clinical trials of β-elemene and how effectively we can use these findings to stratify patients who can benefit most from β-elemene.
AtıfScopus33OpenAlex33İncele - MakaleYalnız künye2019Scopus SJRQ2Apigenin as an effective anticancer natural product: Spotlight on TRAIL, WNT/β-catenin, JAK-STAT pathways, and microRNAs
Ozbey, Ulku; Attar, Rukset; Romero, Mirna Azalea; Alhewairini, Saleh S; Afshar, Behnaz; Uteuliev, Yerzhan Sabitaliyevich; Hanna-Wakim, Lara; Ozcelik, Beraat; Farooqi, Ammad Ahmad
Wealth of information gleaned from decades of high-impact research work; scientists have disentangled the complicated web of versatile regulators that underlie cancer development and progression. Use of structural biology approaches and functional genomics have helped us to gain new insights into complex nature of cancer, and it is now clear that genetic/epigenetic mutations, overexpression of oncogenes, inactivation of tumor suppressors, loss of apoptosis, and versatility of protein binding partners have contributory roles in carcinogenesis and metastatic spread. It is becoming progressively more understandable that reprogramming of gene expression during and nontranscriptional changes during cancer development and progression are initiated and controlled by deregulated signal transduction cascades, all of which collectively create an incalculable complexity. Data obtained through preclinical and clinical trials revealed that alterations in the targeted oncogenes and other downstream, and parallel pathways played a central role in the development of resistance against different therapeutics. Phytochemicals have regained limelight, and different natural products are currently being tested for efficacy in preclinical studies. Apigenin, a plant-derived flavonoid has considerable pharmacological value and is reportedly involved in the regulation of different signaling cascades. In this review, we have attempted to summarize rapidly evolving understanding of molecular biologists and pharmacologists about the potential of apigenin in the regulation of deregulated signaling pathways in different cancers. We have emphasized on the regulation of WNT/β-catenin and janus kinase/signal transducers and activators of transcription (JAK-STAT) pathways. We also comprehensively discuss how apigenin restored apoptosis in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant cancers. The review also gives a snapshot of microRNAs (miRNAs) that regulate wide-ranging biological processes, and it is now clear that each miRNA can control hundreds of gene targets. Apigenin was noted to upregulate miR-520b and miR-101 in different cancers to inhibit tumor growth. Moreover, apigenin-induced apoptotic rate was significantly higher when used in combination with miR-423-5p inhibitors or miR-138 mimics. Better comprehension of linear and integrated signaling pathways will be helpful in effective therapeutic targeting of deregulated signaling pathways to inhibit/prevent cancer.
AtıfScopus65OpenAlex66İncele - MakaleAçık Erişim2018Scopus SJRQ3Maslinic acid as an effective anticancer agent
Lin, Xiukun; Ozbey, Ulku; Uteuliyev, Yerzhan Sabitaliyevich; Attar, Rukset; Ozcelik, Beraat; Zhang, Yuanyan; Guo, Mingyue; Liu, Minghua; Alhewairini, Saleh S.; Farooqi, Ammad Ahmad
Maslinic acid (2α,3β-dihydroxyolean-12-en-28-oic acid) is a naturally occurring pentacyclic triterpenic compound. Maslinic acid is gradually gaining attention as an excellent pharmacologically active product because of its premium biological properties. In this review we will focus on chemopreventive properties of Maslinic acid against different cancers. Seemingly, available data is limited and we have yet to unravel how Maslinic acid therapeutically targeted oncogenic cell signal transduction cascades in different cancers. Moreover, there are visible knowledge gaps about the ability of Maslinic acid to modulate oncogenic and tumor suppressor microRNAs in various cancers.
AtıfScopus20OpenAlex17İncele - Derleme MakaleYayıncıda açık erişim2017Scopus SJRQ3Regulation of signaling pathways by tanshinones in different cancers
Lin, X.; Qureshi, M.Z.; Romero, M.A.; Khalid, S.; Aras, A.; Ozbey, U.; Farooqi, A.A.
Past several years have witnessed dramatic leaps in our understanding of rewiring of gene expression at the translation level during cancer developmentthat provides linchpin support to the transformed phenotype. Most recent and ground-breaking developments in the field of molecular oncology aredriven by an explosion in technological advancements and have started to reveal previously unimagined regulatory mechanisms and how they intricately co-ordinate to modulate cancer progression, loss of apoptosis and development of resistance against different therapeutics. However, the insights gained from work in this natural product research have far-reaching impact because of rapidly increasing repertoire of medicinally and biologically efficient phytochemicals. How Tanshinones mediate targeting of JAK-STAT, ER stress associated signaling cascade,PI3K/AKT/mTOR pathway,autophagy, TRAIL pathway and microRNAs are being discovered and will prove to be helpful in getting a step closer to personalized medicine.
AtıfScopus12OpenAlex12İncele - Derleme MakaleAçık Erişim2017Scopus SJRQ3Regulation of signal transduction cascades by Pterostilbenes in different cancers: Is it a death knell for oncogenic pathways
Butt, Ghazala; Attar, Rukset; Tabassum, Sobia; Aras, Aliye; Qadir, Muhammad Imran; Ozbey, Ulku; Alaaeddine, Nada; Ozcelik, Beraat; Farooqi, Ammad Ahmad
Interdisciplinary research has revolutionized the field of medicine and we have witnessed exponential increase in the high-impact research in past few decades. However, the road to this burgeoning research field is obstacle-ridden because of intratumor heterogeneity, loss of apoptosis and dysregulation of spatio-temporally controlled signaling pathways. Ground-breaking findings obtained through genetic, genomic and proteomic studies have considerably improved our concepts related to the complexity of protein network and excitingly, discovery of miRNAs has added another layer of intricacy to quantitatively regulated gene networks. In this review, we chronicle the milestone achievements and discuss how Pterostilbenes effectively regulated different cellular pathways. We have provided detailed mechanistic insights related to regulation of JAK-STAT signaling, Notch pathway, Wnt mediated intracellular signaling by pterostilbene. Underlying mechanisms about regulation of PI3K/AKT and MAPK pathways by pterostilbene in different cancers. Regulation of Metastasis-associated protein 1 (MTA1) proteins and Human telomerase reverse transcriptase (hTERT) in cancer cells by pterostilbene. Pterostilbene has also been reported to modulate the expression of various oncogenic and tumor suppressor microRNAs in cancer cells. Better and sharper comprehension of the concepts associated with the modes of action of pterostilbene in different cancers will be useful in identification of cancers which can be efficiently targeted by pterostilbene.
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