Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Serdar, Osman(4)
- Aksu, Onder(2)
- Aydin, Ayşe Nur(2)
- Can, Erkan(2)
- Demir, Veysel(2)
- Kocabas, Mehmet(2)
- Alişer, Ahmet Bedrettin(1)
- Aydin, Rahmi(1)
- Başaran, Ertuğrul(1)
- Can, Safak Seyhaneyildiz(1)
- Danabas, Durali(1)
- Demirtaş Erol, Nida(1)
- Gulec, Azime Kucukgul(1)
- Kehayias, George(1)
- Ketenalp, Zozan(1)
- Kocabaş, Mehmet(1)
- Kutluyer Kocabaş, Filiz(1)
- Kutluyer, Filiz(1)
- Neşe Akçanal Ödün(1)
- Ozcan, Ebru Ifakat(1)
- Ozcelik, Mehtap(1)
- Yabanli, Murat(1)
- Yildirim, Numan(1)
- Yildirim, Nuran Cikcikoglu(1)
- Zozan Ketenalp(1)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ3Determination of Oxidative Stress Responses Induced by the Combination of 4 Different Rare Earth Elements in Dreissena polymorpha; [Determinacija odgovorov na oksidativni stres, ki ga povzroča kombinacija 4 različnih redkih zemljinskih elementov v Dreissena polymorpha]
Serdar, Osman; Aydin, Ayşe Nur
Rare Earth Elements (REE), whose usage areas are increasing day by day, are increasing in the amount of mixing with the environment, causing changes in antioxidant enzyme activities by causing oxidative stress in living organisms. In this study, it was aimed to examine the oxidative stress responses induced by the mixture of 4 different REEs (terbium, gadolinium, Lanthanum, Praseodymium) in Dreissena polymorpha. For this purpose, sublethal concentration values were determined by literature review. Experimental application was carried out within 24 and 96 hours. In the analyzes performed to determine biomarker responses, samples taken from living organisms were weighed and homogenization processes were performed for the analysis of samples taken from the experimental groups, including the control group. After homogenization, samples were centrifuged at 4.000 rpm for 15 minutes. Supernatants were kept at -86 °C until measurements were made. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities, and glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) levels were determined using ELISA kits. Statistical analyses were performed using SPSS. One-way ANOVA (Duncan’s multiple range test; p < 0.05) was used for comparison of measured parameters among groups. As a result of the application, a decrease in CAT activity and GSH level and an increase in TBARS levels were observed after 96 hours compared to the control group, while no statistically significant difference was detected in SOD and GPx activities.
- MakaleAçık Erişim2025Scopus SJRQ4The effect of the pesticide Klaxon on the oxidative stress and the antioxidant responses of the Zebra mussel (Dreissena polymorpha); [El efecto del pesticida Klaxon sobre el estrés oxidativo y las respuestas antioxidantes del mejillón cebra (Dreissena polymorpha)]
Ozcan, Ebru Ifakat
Klaxon pesticide represents a novel generation of insecticide employed in the control of diseases, pests and weeds in select agricultural regions. Pesticides that enter the aquatic environment indirectly have a detrimental impact on the organisms that inhabit this environment, and humans are ultimately exposed to these chemicals through the food chain. The present study investigated the toxicity of the klaxon pesticide in Dreissena polymorpha, a suitable bioindicator of water pollution, through the analysis of oxidative stress and metabolic biomarkers. The effects of klaxon at concentrations of 0.01, 0.15 and 0.30 mg·L-1 on oxidative stress and antioxidant changes in D. polymorpha were determined over a 24 – and 96–hour period. Enzyme–linked immunosorbent assay (ELISA) kits were employed to quantify the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and thiobarbituric acid (TBARS), as well as to assess the levels of reduced glutathione (GSH). ELISA kits were used to determine results. Statistical evaluation of biomarker analyzes was performed using the SPSS 24.0 package program one–way ANOVA (Duncan 0.05) test. Significant decreases in GSH levels (P<0.05); significant increases in TBARS levels (P<0.05) were observed. Significant decreases (P<0.05) in SOD, CAT and GPx activities were observed. Considering the study data, it was determined that the klaxon pesticide penetrating the body of the living organism caused oxidative stress and changes in enzyme activities in D. polymorpha.
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İncele - MakaleYalnız künye2025Scopus SJRQ1Effect of light and noise pollution on oxidative stress and proximate composition in Dreissena polymorpha
Serdar, Osman; Demirtaş Erol, Nida; Aydin, Ayşe Nur
In this study, it was aimed to determine the effect of sound and light pollution on Zebra mussel (Dreissena polymorpha) by biomarker and nutritional composition. For this purpose, an experimental design was carried out in laboratory conditions where the model was exposed to live sound, light, and combined sound + light parameters for 30 min every hour over 96 h. Changes in the biomarkers superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities, as well as glutathione (GSH) and thiobarbituric acid (TBARS) levels, were assessed in the model organism exposed to sound, light, and sound + light pollution. The changes in protein and fat amounts were determined. When the changes in biomarkers were examined statistically compared to the control, there was no significant decrease in SOD activity (p < 0.05), a significant increase in CAT activity in sound and sound+light, but a significant decrease in light (p < 0.05), no significant difference in GPx activity (p > 0.05). It was determined that there was a significant increase in GSH and TBARS levels in all three parameters. Significant changes were also observed in the proximate composition. As a result, exposure to sound, light and sound+light pollution caused an increase in oxidative damage and decreases in protein and lipid composition were detected.
AtıfScopus7WoS6OpenAlex8İncele - MakaleAçık Erişim2025Scopus SJRQ4Biochemical Responses of Zebra Mussel Dreissena polymorpha (Pallas, 1771) (Bivalvia: Dreissenidae) against Cadmium
Alişer, Ahmet Bedrettin; Aydin, Rahmi; Serdar, Osman
The biochemical reactions of zebra mussels Dreissena polymorpha (Pallas, 1771) exposed to different concentrations of cadmium (Cd) in the acute period (24 and 96 hours after treatment) were studied. Four variants of experimental treatment were examined: 0 μg/L Cd (control), 10 μg/L Cd, 20 μg/L Cd and 40 μg/L Cd. Changes in the enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) levels were determined using ELISA kits. In D. polymorpha exposed to the three experimental concentrations of cadmium, there was a statistically significant decrease (p<0.05) in SOD enzyme activity with increasing concentration or exposure times. No change was observed in CAT enzyme activity with increasing concentrations. The decrease in the activity depending on the exposure times was not statistically significant (p>0.05). As for GPx enzyme activity, a significant increase was detected after Cd application compared to the control (p<0.05). TBARS and GSH levels increased significantly in all Cd application groups compared to the control at 24 and 96 hours. The effects of different concentrations of Cd on D. polymorpha in the acute period were associated with changes in SOD, CAT, GPx enzyme activities. TBARS and GSH levels were effective parameters in determining the oxidative damage caused by Cd.
- MakaleYalnız künye2024Scopus SJRQ2Seasonal Monitoring of Heavy Metal Pollution in Water and Zebra Mussels Dreissena polymorpha as a Potential Bioindicator Species from Lake Habitat
Kutluyer Kocabaş, Filiz; Başaran, Ertuğrul; Kocabaş, Mehmet
In aquatic ecosystem, metal pollution is an important environmental hazard. Mussels as a bioindicator species are often used for assessment the presence of potentially toxic metals. Hence, the present study aimed to assess the effect of seasonal variations on some heavy metals (Cd, Cr, Pb, As, Zn and Cu) accumulation in water and Dreissena polymorpha from lake habitat. Our result indicated that Zn accumulated at a very high level in the zebra mussels while As accumulated at a high level in water samples. Seasonal variations significantly affected Cu concentration in the water samples (P < 0.05) while Cr concentration in the mussel samples was significantly affected by seasonal variations (P < 0.05). According to the water analysis, mean concentrations of metals are below the maximum limits established by the World Health Organization and USEPA, except As. Overall, our data emphasize anthropogenic pollution in the Turkish aquatic environment and confirm the use of D. polymorpha as a prospective biomonitor for metal polluted sites’.
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İncele - MakaleAçık Erişim2024Scopus SJRQ3Toxicity assessment of advanced biological wastewater treatment plant effluent by integrated biomarker response in zebra mussels (Dreissenapolymorpha)
Serdar, Osman; Ketenalp, Zozan; Yildirim, Nuran Cikcikoglu
In this study, zebra mussels (Dreissena polymorpha) were exposed to advanced biological wastewater treatment plant effluent (ABWTPE) for 96 h. At the end of the 96th hour, antioxidant parameters such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione S-transferase (GST), malondialdehyde (MDA) and glutathione (GSH) were examined. The objective of the study was to identify biomarkers that are useful for assessing the potential toxic effects of ABWTPE in freshwater environments. We observed an increase in GPX, SOD activity and MDA levels, and a decrease in CAT, GST activity and GSH levels. The results obtained in our study showed that the measured biochemical parameters (GSH, MDA, SOD, CAT, GPX and GST) are useful biomarkers in determining the possible toxicity of ABWTPE in aquatic environments.
AtıfScopus3WoS3OpenAlex3İncele - Doktora TeziAçık Erişim2022Probiyotiklerin zebra midye (Dreissena polymorpha)'de malathion toksisitesi üzerindeki iyileştirici etkisinin bazı biyokimyasal parametreler ile belirlenmesi
Neşe Akçanal Ödün
Probiyotikler, konakçı olduğu organizmaların sağlığı açısından yararlı sindirim kanalı mikroorganizmaları olarak tanımlanabilirler. Artan nüfusun gıda gereksinimlerini karşılamak amacıyla birim alandan daha fazla ürün elde etmek için zararlılarla mücadelede kullanılan pestisitler, sentetik veya doğal ürünlerdir. Pestisit kullanımının ekosistem üzerinde doğrudan ve dolaylı birtakım zararları bulunmaktadır. Sunulan bu çalışmada, malathion etken maddeli pestisitin hedef dışı sucul bir organizma olan zebra midye (Dreissena polymorpha) üzerindeki etkisinin biyobelirteçlerle belirlenmesi, probiyotik kullanımı esnasındaki koruyucu etkisinin biyobelirteçlerle belirlenmesi amaçlanmıştır. Malathiona maruz bırakılan D. polymorpha'da LC50 değeri 120,11 ± 19,32 mg/l olarak hesaplanmıştır. Probiyotik ile muamele edilen D. polymorpha bireyleri ve doğrudan D. polymorpha bireyleri malathion etken maddeli pestisite LC50 değerine oranla (1/5, 1/10 ve 1/20) sublethal konsantrasyonlarına 24 ve 96 saatlik zaman zarfında maruziyet sağlanmıştır. Deneme gruplarından alınan doku supernatantlarında, tiobarbitürik asit reaktif maddeleri (TBARS) ve redükteglutatyon (GSH) düzeyleri ile superoksitdismutaz (SOD), katalaz (CAT) ve glutatyon peroksidaz (GPx), enzim aktiviteleri tespit edilmiştir. Ayrıca deneme gruplarından alınan örneklerde histopatolojik yanıt değerlendirilmiştir. Malathiona maruz bırakılan D. polymorpha bireylerinde TBARS seviyelerinde artışa, GSH seviyesinde azalışa, SOD enzim aktivesinde azalışa, CAT enzim aktivesinde azalışa, GPx enzim aktivitesinde azalışa sebebiyet verdiği tespit edilmiştir. Histopatolojik yanıtın araştırıldığı gruplarda artan konsantrasyona bağlı olarak uygulama gruplarında probiyotik kullanılmayan gruba kıyaslandığında probiyotik kullanılmayan gruplarda şiddetli lezyonlar tespit edilmiştir Koruyucu olarak uygulanan probiyotik ile muamele edilen grupların hepsinde doğrudan maruziyete kıyasla istatistiksel açıdan anlamlı farklar bulunmuştur. Probiyotik ile muamele edilen grupların histopatolojik yanıtları doğrudan uygulama gruplarına kıyasla hafif ve orta şiddetli lezyonlar olarak koruyucu etkisi gösterdiği belirlenmiştir. Yapılan deneysel çalışmada D. polymorpha'da malathion uygulamasında kullanılan biyobelirteçlerin faydalı olduğu biyokimyasal ve histopatolojik analizlerle belirlenmiştir. Sucul organizmalarda probiyotik kullanımının iyileştirici etkisinin olduğu hem biyokimyasal hem de histopatolojik biyobelirteçlerle teyit edilmiştir.
- Yüksek Lisans TeziAçık Erişim2022Lambda siyalotrin etken maddeli insektisintin farklı sıcaklıklarda Dreissena polymarpha'daki bazı biyokimyasal etkilerinin belirlenmesi
Zozan Ketenalp
Günümüzde İklim değişikliğinin giderek artması nedeniyle iklim değişikliklerinin birincil göstergesi olarak kabul edilin sıcaklığın etkisi önemli bir hale gelmiştir. Yapılan bu çalışma ile farklı sıcaklıklarda subletal konsantrasyonlarda Lambda Cyhalotrin'e 24 ve 96 saat boyunca maruz kalan Dreissena polymorpha 'da maruziyet sonrası, nörotoksisitenin bir göstergesi olan AChE ile oksidatif stres biyobelirteçleri katalaz (KAT) ve Süperoksit Dismutaz (SOD) enzim aktiviteleri ile Glutatyon (GSH) ve Malondialdehit (MDA) seviyelerindeki değişimlerin belirlenmesi amaçlanmıştır. Bu amaçla SOD, KAT, AChE aktiviteleri ile GSH ve MDA düzeyleri ticari kitler kullanılarak belirlenmiştir. Elde edilen sonuçlara göre; Lambda cyhalothrin uygulamasımasına bağlı olarak MDA seviyelerinde istatistiksel olarak önemli artış bulunurken, GSH seviyelerinde ise bir azalış saptanmıştır. AChE seviyelerinde; genel olarak bir inhibisyon gözlenmiştir. Bu inhibisyon, özellikle yüksek doz lambda-Cyhalothrin uygulanan gruplarda görülmektedir.. Uygulama sürelerine bağlı olarak inhibisyon düzeylerinin arttığı da saptanmıştır. SOD enzim aktivitesi ise azalırken KAT enzim aktivitesi uygulama dozuna bağlı olarak artmıştır. Farklı sıcaklık uygulamalarının Lambda-cyhalothrin'in toksik etkileri üzerine farklı etkiler meydana getirdiği görülmüştür. Bu çalışmada uygulanan konsantasyonlarda lambda-cyhalothrinin oksidatif strese ve nörotokisiteye neden olduğu ve Lambda-cyhalothrin'in toksisitesinin sıcaklığa bağlı olarak değiştiği görülmüştür.
- MakaleAçık Erişim2013Scopus SJRQ4Bioaccumulation of Copper and Zinc in Freshwater Crayfish (Astacus leptodactylus) Fed with Zebra Mussels (Dreissena polymorpha) Collected from Keban Dam Lake, Turkey
Aksu, Onder; Gulec, Azime Kucukgul; Demir, Veysel; Danabas, Durali; Yildirim, Numan; Ozcelik, Mehtap; Can, Erkan; Kocabas, Mehmet
This study is aimed to determine the bioaccumulation of copper and zinc in hemolymph of freshwater crayfish (Astacus leptodactylus) fed with zebra mussel (Dreissena polymorpha) collected from Keban Dam Lake. This is the first study on bioaccumulation of Cu and Zn in hemolymph of males and females of A. leptodactylus. The average concentrations of Cu and Zn in the hemolymph samples were found out as 0.54 and 35.07 ppm respectively for male and 0.42 and 15.59 ppm respectively for female control freshwater crayfish. The levels of Zn in the hemolymph of both male and female ones among control and diet groups were statistically significant (P < 0.05). The Cu levels among control and diet groups in female ones were statistically significant (P < 0.05) but not in the male ones (P > 0.05). The results of current study revealed that feed treatment with boiling was not effective at the levels of metal bioaccumulation in hemolymph. It was observed that this metal bioaccumulation is more related with sex differences.
AtıfWoS2OpenAlex2İncele - MakaleYalnız künye2012Scopus SJRQ3COMPARISON OF HEAVY METALS BIOACCUMULATION BY DREISSENA POLYMORPHA (PALLAS, 1771) AND UNIO ELONGATULUS EUCIRRUS (BOURGUIGNAT, 1860) FROM KEBAN DAM LAKE, TURKEY
Aksu, Onder; Yabanli, Murat; Can, Erkan; Kutluyer, Filiz; Kehayias, George; Can, Safak Seyhaneyildiz; Kocabas, Mehmet; Demir, Veysel
The present study aimed to determine and compare the bioaccumulation of heavy metals in two freshwater species of mussels Unio elongatulus eucirrus (Bourguignat, 1860) and Dreissena polymorpha (Pallas, 1771) in Keban Dam Lake, Turkey. The amount of Arsenic (As), Cadmium (Cd), Copper (Cu), Lead (Pb) and Uranium (U) were detected. Heavy metals concentrations (ppm) of these heavy metals in U. e. eucirrus and D. polymorpha were 1.071 and 1.376 for As, 0.174 and 0.335 for Cd, 0.004 and 3.817 for Cu, 0 and 0.267 for Pb, 0.004 and 0.267 for U, respectively. Arsenic concentrations in the tissues of both species have exceeded the maximum permission limits in all sampling sites. The concentrations of Cu and U were considerably greater in D. polymorpha specimens than in U. e. eucirrus (p<0.05). The results obtained from the present study showed that both species accumulated heavy metals generally in the following sequences: Cu > As > Cd > Pb >U. The present results indicated that D. polymorpha may be a better bioindicator of environmental pollution than U. e. eucirrus, since it showed a higher accumulation capacity.
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