Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Başak, Neşe(2)
- Parlak Ak, Tuba(2)
- Seven, Ismail(2)
- Yaman, Mine(2)
- Ak, Tuba Parlak(1)
- Alayunt, Naci O.(1)
- Baykalir, Burcu Gül(1)
- Benzer, F.(1)
- Benzer, Fulya(1)
- Eri̇Şi̇r, Mine(1)
- Gul Baykalir, Burcu(1)
- Gunay, C.(1)
- Gül Baykalir, Burcu(1)
- Güllüoglu, Hakan(1)
- Han, M. C.(1)
- Kandemir, F. M.(1)
- Karagozoglu, Yusuf(1)
- Kocabaş, Mehmet(1)
- Kutluyer, Filiz(1)
- Ozer Kaya, Seyma(1)
- Ozkaraca, M.(1)
- Parlak, Akif E.(1)
- Sagliyan, A.(1)
- Seker, Engin(1)
- Seven, Pinar Tatli(1)
- Seven, İsmail(1)
- Tatli Seven, Pinar(1)
- Tatli Seven, Pınar(1)
- Türkoglu, Semra(1)
Yayınlar
- MakaleAçık Erişim2024Scopus SJRQ4Effect of naproxen on oxidative stress biomarkers in Gammarus pulex; [Efecto del naproxeno sobre los biomarcadores de estrés oxidativo en Gammarus pulex]
Seker, Engin
Non–steroidal anti–inflammatory drugs (NSAIDs) are a widely prescribed medication class that is used in the treatment of numerous conditions worldwide. Of these drugs, naproxen is the most commonly used NSAID. Following administration, non–steroidal anti–inflammatory drugs (NSAIDs) such as naproxen are eliminated from the body in either their original chemical form or as metabolites, ultimately entering the aquatic environment. The current study sought to show the impacts of naproxen on the oxidant/antioxidant status of Gammarus pulex, an aquatic invertebrate (Amphipoda). Gammarus pulex were exposed to sublethal concentrations of naproxen (3.44, 6.87 and 13.75 mg·L-1) for 96 hours (h). Whole body tissue samples were collected after 24, 48 and 96 h of exposure and analysed to determine the oxidant/antioxidant status by quantifying malondialdehyde (MDA) and total glutathione levels (GSH), and superoxide dismutase (SOD), and catalase (CAT) activities of the G. pulex. The level of MDA exhibited a remarkable increase, while the endogenous GSH level showed a significant depletion in tested whole body tissues in a time–dependent manner after naproxen treatment of G. pulex. In G. pulex exposed to the highest dose of naproxen; decreases in GSH activity, SOD and CAT activities were observed.The SOD activity did not show a discernible rise in statistics after 24 and 48 h of exposure, however, a difference was observed after 96 h compared to the control group (P<0.05). The findings of this study demonstrated the capacity of naproxen to initiate oxidative stress and elevate MDA levels in G. pulex, even at remarkably low concentrations. This study emphasizes that it is essential to develop effective methodologies to impede naproxen entry into the aquatic environment.
- MakaleAçık Erişim2020Scopus SJRQ2Bee glue (propolis) improves reproductive organs, sperm quality and histological changes and antioxidant parameters of testis tissues in rats exposed to excess copper
Seven, Ismail; Tatli Seven, Pinar; Gul Baykalir, Burcu; Parlak Ak, Tuba; Ozer Kaya, Seyma; Yaman, Mine
This study was designed to determine the effects of propolis on the sperm quality, antioxidant and histological parameters in the testicular tissues of male Sprague Dawley rats exposed to excessive copper (Cu). In this aim, 24 rats were randomly divided into four groups as follows: the control, Cu, Propolis and Cu+Propolis. When compared to control group, Cu administration significantly decreased sperm motility and concentration, increased total abnormal sperm rate. It caused a significant induction the malondialdehyde (MDA), and reduction the superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) in testicular tissues. Also, it caused loss, disorganisation and vacuolation of the germinal epithelium, oedema of the interstitial tissues, proliferation of the interstitial cells, spilled immature spermatogenic cells in the lumen of some seminiferous tubules. A large number of active caspase-3-positive stained apoptotic cells and a significant decrease in Johnsen's testicular score were determined. However, significant ameliorations were observed in all sperm characteristics, MDA, SOD, CAT, GSH, seminiferous tubules, number of apoptotic cells and Johnsen's testicular score in Cu+Propolis group. Our results showed that oral supplementation of propolis had curative effect on the sperm quality, antioxidant and histological parameters in the testicular tissues of male Sprague Dawley rats exposed to Cu.
AtıfScopus39OpenAlex39
İncele - MakaleAçık Erişim2018Scopus SJRQ4Comparison of oxidant and antioxidant status of Çoruh trout (Salmo coruhensis), anatolian trout (Salmo rizeensis) and rainbow trout (Oncorynchus mykiss) spermatozoa
Kutluyer, Filiz; Kocabaş, Mehmet; Eri̇Şi̇r, Mine; Benzer, Fulya
The aim of present study was to compare oxidant and antioxidant status of Çoruh trout (Salmo coruhensis), Anatolian trout (Salmo rizeensis) and rainbow trout (Oncorynchus mykiss) spermatozoa. Fish were obtained from Uzungöl. Enzymatic antioxidant activities (superoxide dismutase, catalase, glutathione peroxidase), glutathione and lipid peroxidation (malondialdehyde) were determined in spermatozoa of three trout species. Results indicated that catalase (23.36±0.36 K/g.protein), glutathione peroxidase (74.00±1.5 U/g.protein), glutathione (0.57±1.24 µmol/g.cell) and malondialdehyde levels (6.55±2.01 nmol/g cell) were highest levels in Anatolian trout (S. rizeensis) spermatozoa. In conclusion, differences among species caused alterations in the antioxidant and malondialdehyde levels.
AtıfScopus1OpenAlex2TR Dizin1
İncele - MakaleAçık Erişim2018Scopus SJRQ3The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats; [Ratlarda bakır fazlalığına karşı yem tüketimi, antioksidan durum ve karaciğer ile böbrek dokularının histolojik parametreleri üzerine propolis ve fluniksin meglümin'in koruyucu etkileri]
Tatli Seven, Pınar; Gül Baykalir, Burcu; Parlak Ak, Tuba; Seven, İsmail; Başak, Neşe; Yaman, Mine
This experiment was conducted to determine the protective effects of flunixin meglumine and propolis on feed intake, antioxidant status and histological parameters in kidney and liver tissues in rats exposed to excessive copper. In this study individually housed thirty-six male Sprague-Dawley rats were used. Animals were randomly divided into six groups; control, copper sulphate (500 mg/kg BW/day, gavage), flunixin meglumine (2.2 mg/kg BW/day, ip), propolis (100 mg/kg BW/day, gavage), copper sulphate+flunixin meglumine (500 mg/kg BW/day of copper sulphate by gavage and 2.2 mg/kg BW/day of flunixin meglumine, ip) and copper sulphate+propolis (500 mg/kg BW/day of copper sulphate and 100 mg/kg BW/day of propolis by gavage). The study demonstrated that body weight change in the copper sulphate+propolis group significantly ameliorated in comparison with copper group (P<0.01). Propolis and flunixin meglumine administration significantly decreased MDA levels in the kidney and liver tissues, and serum TNF-α levels (P<0.001). Propolis supplementation to rats who were also treated with copper significantly increased the superoxide dismutase, catalase and reduced glutathione activities (P<0.001). Flunixin meglumine and propolis treatments decreased the copper-induced degenerative and necrotic changes with the apoptotic cells in the liver and kidney tissues. In conclusion, propolis appeared to ameliorate the adverse effects on feed intake, liver and kidney tissues seeing in the copper treatment and, apparently caused by the copper toxicity, by scavenging the free radicals and increasing activity of antioxidants.
AtıfScopus10OpenAlex9İncele - MakaleAçık Erişim2018Scopus SJRQ3The protective effects of chrysin and flunixin meglumine against excess copper in male rats
Seven, Pinar Tatli; Baykalir, Burcu Gül; Seven, Ismail; Ak, Tuba Parlak; Başak, Neşe; Güllüoglu, Hakan
Thirty-six Sprague Dawley male rats were housed in individual cages and randomly divided into six groups: Control, copper sulfate (Cu; 500 ppm body weight (BW)/day), flunixin meglumine (FM; 2.2 ppm BW/day), chrysin (chrysin; 50 ppm BW/day), copper sulfate + FM (Cu + FM; 500 ppm BW/day of copper sulfate and 2.2 ppm BW/day of FM), and copper sulfate + chrysin (Cu + Chrysin; 500 ppm BW/day of copper sulfate and 50 ppm BW/day of chrysin). Feed intake (FI) in the Cu + Chrysin group significantly increased in comparison with that of the Cu group (P < 0.01). Cu excess significantly increased malondialdehyde, indicating oxidative stress. Chrysin and FM administration significantly decreased malondialdehyde levels and increased the superoxide dismutase and catalase activities in the liver and kidney tissues (P < 0.001). Serum TNF-α levels were significantly lower in the Cu + FM and Cu + Chrysin groups in comparison to the Cu group (P < 0.001). It was seen that FM and chrysin treatments alleviated degeneration, necrosis, and apoptosis in the liver and kidney tissues of the Cu-treated rats. Chrysin appeared to ameliorate the adverse effects on FI and liver and kidney tissues by scavenging where the free radicals are located and increasing the activity of antioxidants.
AtıfScopus8WoS7OpenAlex9TR Dizin2
İncele - MakaleYalnız künye2013Scopus SJRQ3Effects of oral administrations of pomegranate seed extract on surgical wound healing in rabbits
Kandemir, F. M.; Sagliyan, A.; Ozkaraca, M.; Gunay, C.; Han, M. C.; Benzer, F.
This study examined the effects of orally given pomegranate seed extract (PSE) on healing of surgically induced full thickness skin wounds in terms of clinical, histopathological and biochemical aspects. A total of 48 healthy, adult male New Zealand rabbits were randomly divided in 2 equal experimental (PSE group) and control groups (C): one week prior the surgery, 100 mg/kg per day via gastric catheter pomegranate seed extract was orally given for 20 days to the assay animals. After one week, all rabitts were anaesthetized by intramuscular injection of xylazine HCl (5 mg/kg) and ketamine HCI (50 mg/kg) and after shaving and disinfection, a circular full thickness skin defect of 2.5 cm diameter was incised on the median line of the back area. Macroscopic and histopathological aspects as well as the tissue oxidant/antioxidant balance were determined on 6 rabbits from each group slaughtered at the 5th, 10th, 15th and 20th days post-surgery.
AtıfWoS9İncele - MakaleYalnız künye2013Scopus SJRQ2THE EFFECTS OF HYDROXYUREA DERIVATIVE 1, 3, 4-THIADIAZOLES ON SERUM BIOCHEMICAL PARAMETERS AND ANTIOXIDANT STATUS IN LIVER OF RATS
Karagozoglu, Yusuf; Türkoglu, Semra; Parlak, Akif E.; Alayunt, Naci O.
In this study, it was aimed to investigate the antioxidant and antihepatotoxic effect of hydoxyurea derivative 1,3,4-thiadiazoles on serum biochemical parameters (AST, ALT, LDH, urea, creatinine and total bilirubin) and antioxidant parameters (SOD, CAT, GPX, MDA). In our study, a total of 35 adult male wistar rats were divided into 5 equal groups. DMSO diluted with only corn oil, was injected to the control group. 25 mg/kg ligand, 25 mg/kg thiadiazole-manganese, 25 mg/kg thiadiazole-cadmium and 25 mg/kg thiadiazole-chrome complexes was injected to the experimental groups rats subcutaneously for 15 days with three-day interval during the test. After blood samples were centrifuged AST, ALT, LDH enzyme activites hepatic injury; and then, the activites of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and the level of malondialdehyde (MDA) in liver tissues were determined spectrophotometrically. The level of AST was found to be lower (p<0.05) in the Cr-L group than in other groups. The levels of ALT and total bilirubine were found to be lower (p<0.05) in the Cd-L group than in other groups. The level of SOD was found to be higher (p<0.05) in the Cd-L group than in other groups. The levels of GPX was found to be lower (p<0.05) in the Cr-L group than in other groups. As a result, it can be concluded that their pharmacological characteristics can be beneficial in many fields of application because hydroxyurea derivative 1,3,4 thiadiazole compounds show the antioxidant and antihepatotoxic activity.
AtıfWoS1İncele