Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Gul, Muhammet(110)
- Güler, Ömer(70)
- Akkurt, Nevzat(69)
- Serdar, Osman(57)
- Yucesan, Melih(55)
- Celik, Erkan(53)
- Tekin, H.O.(52)
- ALMisned, Ghada(49)
- Bulut, Hasan(49)
- Baskonus, Haci Mehmet(48)
- Paksoy, Mehmet Yavuz(46)
- Yildirim, Numan(45)
- Kocabaş, Mehmet(41)
- Yildirim, Nuran Cikcikoglu(41)
- Zengin, Gokhan(40)
- Alataş, Mevlüt(39)
- Ince, Muharrem(38)
- Benzer, Fulya(37)
- Mete, Suleyman(34)
- Aslan, Naim(33)
- Kutlu, Banu(33)
- Yildirim, Ozal(33)
- Topal, Murat(32)
- Tanyol, Mehtap(30)
- Batan, Nevzat(28)
- Özkul, İskender(28)
- Kök, Mediha(27)
- Utku, Anıl(27)
- Can, Erkan(26)
- Danabas, Durali(26)
- Sulaiman, Tukur Abdulkadir(26)
- Ates, Mehmet(25)
- Ezer, Tülay(25)
- Guler, Omer(25)
- Kutluyer, Filiz(25)
- Say, Yakup(25)
- Serin, Faruk(25)
- Erguven, Gokhan Onder(24)
- Onat, Onur(24)
- Cakilcioglu, Ugur(23)
Yayınlar
- MakaleAçık Erişim2019Scopus SJRQ4Investigation of relaxation times in 5-fluorouracil and human serum albumin mixtures
Korunur, Sibel; Zengin, Bilgin; Yilmaz, Ali
Background: Human serum albumin (HSA) is often selected as a subject of any study because albumin is the most abundant protein in human blood plasma. NMR is recognized as a valuable method to determine the structure of proteins-ligand and protein-drug complexes. Objective - Aim of the study: In this study, protein drug interactions were investigated using 5-Fluorouracil anticancer drug and human serum albumin protein. Materials and methods: In this context 400 MHz NMR spectrometry was used and NMR relaxation rates in drug-albumin complex were investigated with respect to increase albumin concentration and increase in 5-Fluoro-uracil (5-FU)-albumin solution temperature. Results: The results of this study indicated that 5-FU had a weak association with albumin, and it easily dissociated from the protein to which it was attached. Conclusion: The obtained results also gave us useful information about molecular dynamics of drug-albumin interactions.
AtıfScopus4WoS3OpenAlex4TR Dizin1
İncele - MakaleAçık Erişim2019Scopus SJRQ3Hybrid parliamentary optimization and big bang-big crunch algorithm for global optimization
Kiziloluk, Soner; Özer, Ahmet Bedri
Researchers have developed different metaheuristic algorithms to solve various optimization problems. The efficiency of a metaheuristic algorithm depends on the balance between exploration and exploitation. This paper presents the hybrid parliamentary optimization and big bang-big crunch (HPO-BBBC) algorithm, which is a combination of the parliamentary optimization algorithm (POA) and the big bang-big crunch (BB-BC) optimization algorithm. The intragroup competition phase of the POA is a process that searches for potential points in the search space, thereby providing an exploration mechanism. By contrast, the BB-BC algorithm has an effective exploitation mechanism. In the proposed method, steps of the BB-BC algorithm are added to the intragroup competition phase of the POA in order to improve the exploitation capabilities of the POA. Thus, the proposed method achieves a good balance between exploration and exploitation. The performance of the HPO-BBBC algorithm was tested using well-known mathematical test functions and compared with that of the POA, the BB-BC algorithm, and some other metaheuristics, namely the genetic algorithm, multiverse optimizer, crow search algorithm, dragonfly algorithm, and moth-flame optimization algorithm. The HPO-BBBC algorithm was found to achieve better optimization performance and a higher convergence speed than the above-mentioned algorithms on most benchmark problems.
AtıfScopus3WoS1OpenAlex3İncele - MakaleAçık Erişim2019Scopus SJRQ3Bioactivity-guided isolation of anti-inflammatory principles from Cistus parviflorus Lam.
Gürbüz, Perihan; Doğan, Şengül Dilem; Çelik, Gizem Nur; Bekci, Hatice; Cumaoğlu, Ahmet; Gündüz, Miyase Gözde; Paksoy, Mehmet Yavuz
Bioactivity-guided fractionation and purification of Cistus parviflorus led to the isolation of two flavan-3-ol derivatives; gallocatechin (1) and epigallocatechin (2) and two flavonoid glycosides; avicularin (3) and trans-tiliroside (4). The structures of the compounds were elucidated on the basis of NMR and ESIMS data. All compounds were isolated from C. parviflorus for the first time. Compounds 2 and exhibited antiinflammatory activity through decreasing the NOS2 and COX2 levels on LPS+IFN-γ treated RAW 264.7 cells. Molecular docking studies of avicularin, the most potent compound, were carried out in the active sites of NOS2 and COX2 to predict the most plausible binding modes and support the experimental data.
AtıfScopus7OpenAlex8TR Dizin2İncele - MakaleYalnız künye2019Scopus SJRQ1Deep long short-term memory networks-based automatic recognition of six different digital modulation types under varying noise conditions
Daldal, Nihat; Yıldırım, Özal; Polat, Kemal
In this paper, a new method based on deep learning has been proposed in order to recognize noise-digital modulation signals at varying noise levels automatically. The 8-bit data from six different modulations have been obtained by adding noise levels from 5 to 25 dB. The used digital modulation types are Amplitude Shift Keying, Frequency Shift Keying, Phase Shift Keying, Quadrature Amplitude Shift Keying, Quadrature Frequency Shift Keying, and Quadrature Phase Shift Keying. To recognize the noise-digital modulation signals automatically, a new deep long short-term memory networks (LSTMs) model has been proposed and then applied to these signals successfully. A significant advantage of the proposed system is that deep learning method has been trained and tested with raw digital modulation signals without applying any feature extraction from the signals. In this study, the noise modulation signals of 5–25 dB have been classified and compared with each other. The innovative aspect of the study is to classify the modulation with the LSTM method without dealing with the extraction of signal characteristics. Without noise, added digital modulation signals had been classified as the success rate of 97.22%, while with all noise-added signals have been classified as the success rate of 94.72% with deep LSTM model. The experimental results show that the proposed deep LSTM model has been achieved remarkable results in recognition of noised six different modulation signals with a fully end-to-end structure.
AtıfScopus35WoS26OpenAlex35İncele - MakaleYalnız künye2019Scopus SJRQ1Combined boron, radiogenic (Nd, Pb, Sr), stable (C, O) isotopic and geochemical investigations of carbonatites from the Blue River Region, British Columbia (Canada): Implications for mantle sources and recycling of crustal carbon
Çimen, Okay; Kuebler, Corinne; Simonetti, Stefanie S.; Corcoran, Loretta; Mitchell, Roger; Simonetti, Antonio
This study reports the combined major, minor and trace element compositions, and stable (C, O), radiogenic (Nd, Pb, and Sr) isotopic compositions, and first δ11B isotopic data for the Fir, Felix, Gum, and Howard Creek carbonatites from the Blue River Region, British Columbia (Canada). These sill-like occurrences were intruded into Late Proterozoic strata during rifting and extensional episodes during the Late Cambrian and Devonian -Mississippian, and subsequently deformed and metamorphosed to amphibolite grade in relation to a collisional-type tectonic environment. The carbonatites at Fir, Gum, and Felix contain both calcite and dolomite, whereas the carbonatite at Howard Creek contains only calcite. The dolomite compositions reported here are consistent with those experimentally determined by direct partial melting of metasomatized peridotitic mantle. The combined major and trace element compositions and δ13CPDB (−5.37 to −4.85‰) and δ18OSMOW (9.14 to 9.62‰) values for all the samples investigated are consistent with those for primary igneous carbonate and support their mantle origin. However, these signatures cannot be attributed to closed system melt differentiation from a single parental melt. The initial Nd, Pb, and Sr isotopic ratios are highly variable and suggest generation from multiple, small degree parental melts derived from a heterogeneous mantle source. The δ11B values for carbonates from Felix, Gum, and Howard Creek vary between −8.67 and −6.36‰, and overlap the range for asthenospheric mantle (−7.1 ± 0.9‰), whereas two samples from Fir yield heavier values of −3.98 and −2.47‰. The latter indicate the presence of recycled crustal carbon in their mantle source region, which is consistent with those for young (<300 Ma) carbonatites worldwide. The radiogenic and B isotope results for the Blue River carbonatites are compared to those from contrasting, anorogenic tectonic settings at Chipman Lake, Fen, and Jacupiranga, and indicate that similar upper mantle sources are being tapped for carbonatite melt generation. The pristine, mantle-like δ11B values reported here for the Blue River carbonatites clearly demonstrate that this isotope system is robust and was not perturbed by post-solidification tectono-metamorphic events. This observation indicates that B isotope signatures are a valuable tool for deciphering the nature of the upper mantle sources for carbonates of igneous origin.
AtıfScopus28OpenAlex25İncele - MakaleAçık Erişim2019Scopus SJRQ2Improvement of sperm motility of Oncorhynchus mykiss and Salvelinus fontinalis by L-tryptophan
Kocabaş, Mehmet; Kutluyer, Filiz; Ertekin, Özlem; Aksu, Önder; Başçınar, Nadir
Experiments were designed to test the influence of L-tryptophan supplementation of the extender on the sperm motility parameters and bacterial flora of brook trout (Salvelinus fontinalis) and rainbow trout (Oncorhynchus mykiss). The extender containing 0.3 M glucose in 10% Dimethyl sulfoxide (DMSO) was supplemented with 0, 0.5, 1, 2, and 4 mM L-tryptophan. Sperm samples stored for up to 12 days at 4°C for brook trout were motile while motility was not observed after six days of storage for rainbow trout. Diluted sperm samples were spread-plated onto Plate Count Agar (PCA) (Total Bacteria Count), Rose Bengal Agar (RBC) (Yeast-Mold Count), Violet Red Bile Dextrose (VRBD) (Enterobacteriaceae count) and Mannitol Salt Agar (MSA) (Micrococcus/Staphylococcus count) and counts were performed in duplicate and sampling occurred on day 0, 2, 4, 6, and 12 of cold storage. L-tryptophan supplementation of the extender yielded a positive effect, significantly prolonging sperm motility in S. fontinalis and O. mykiss compared to the control group (p < 0.05). The ideal results were obtained above a concentration of 0.5 mM for both species. Total bacteria count in fresh sperm (undiluted samples) was not detectable and not detected in sperm samples treated with different L-tryptophan concentrations. Yeast-mold, Enterobacteriaceae and Micrococcus/Staphylococcus were not detected from fresh and treated sperm brook trout and rainbow trout. On the basis of the results, L-tryptophan-based extender is useful for maintaining sperm quality in short-term storage. L-tryptophan had a negative effect on the bacterial flora. The results of the current study encourages further studies related to long-term storage and reproduction management. Abbreviations: DMSO: dimethyl sulfoxide; PCA: plate count agar; RBC: rose Bengal agar; VRBD: violet red bile dextrose; MSA: mannitol salt agar; SCA: sperm class analyzer; CFU: colony-forming unit.
AtıfScopus13WoS14OpenAlex13
İncele - MakaleYalnız künye2019Scopus SJRQ2Influence of RE oxides (Eu3+, Sm3+, Nd3+) on gamma radiation shielding properties of lead fluoroborate glasses
Wagh, Akshatha; Sayyed, M.I.; Askin, A.; Özpolat, Özgür Fırat; Sakar, E.; Lakshminarayana, G.; Kamath, Sudha D.
Authors report the change in lead fluoroborate glass properties with change in RE2O3 (RE = Eu, Sm, Nd) chemical composition. The RE2O3 exhibited improvement in the radiation shielding properties of the glass samples. The gamma rays shielding capabilities of the samples were studied using the WinXcom software (for Eu2O3, Sm2O3 doped glasses) and Monte Carlo simulation (for Nd2O3 doped glasses). The results exhibited that the mass attenuation coefficient (μm), effective atomic number (Zeff), and half value layer (HVL) depends on the concentration of RE2O3 and addition of the same significantly increased the shielding capabilities of the glass samples against gamma rays. The increase in photon energy revealed the decrease in radiation shielding properties. The reported density and radiation attenuation properties of RE2O3 doped lead fluoroborate glasses are predominant in radiation shielding applications which will be useful in high strength structures. Of all the glass samples 2.5 mol% of Eu2O3, Sm2O3 and Nd2O3 doped glasses showed enhanced shielding properties.
AtıfScopus40OpenAlex41İncele - MakaleYalnız künye2019Scopus SJRQ1A new approach for arrhythmia classification using deep coded features and LSTM networks
Yildirim, Ozal; Baloglu, Ulas Baran; Tan, Ru-San; Ciaccio, Edward J.; Acharya, U. Rajendra
Background and objective: For diagnosis of arrhythmic heart problems, electrocardiogram (ECG)signals should be recorded and monitored. The long-term signal records obtained are analyzed by expert cardiologists. Devices such as the Holter monitor have limited hardware capabilities. For improved diagnostic capacity, it would be helpful to detect arrhythmic signals automatically. In this study, a novel approach is presented as a candidate solution for these issues. Methods: A convolutional auto-encoder (CAE)based nonlinear compression structure is implemented to reduce the signal size of arrhythmic beats. Long-short term memory (LSTM)classifiers are employed to automatically recognize arrhythmias using ECG features, which are deeply coded with the CAE network. Results: Based upon the coded ECG signals, both storage requirement and classification time were considerably reduced. In experimental studies conducted with the MIT-BIH arrhythmia database, ECG signals were compressed by an average 0.70% percentage root mean square difference (PRD)rate, and an accuracy of over 99.0% was observed. Conclusions: One of the significant contributions of this study is that the proposed approach can significantly reduce time duration when using LSTM networks for data analysis. Thus, a novel and effective approach was proposed for both ECG signal compression, and their high-performance automatic recognition, with very low computational cost.
AtıfScopus377OpenAlex388İncele - MakaleAçık Erişim2019Scopus SJRQ4Paenidigyamycin g: 1-acetyl-2,4-dimethyl-3-phenethyl-1H-imidazol-3-ium
Tetevi, Gilbert Mawuli; Kwain, Samuel; Mensah, Thomas; Camas, Anil Sazak; Camas, Mustafa; Dofuor, Aboagye Kwarteng; Azerigyik, Faustus Akankperiwen; Oluwabusola, Emmanuel; Deng, Hai; Jaspars, Marcel
The Ghanaian Paenibacillus sp. DE2SH (GenBank Accession Number: MH091697) is a prolific producer of potent antiparasitic alkaloids. Further detailed study of the culture broth of this strain produced the compound Paenidigyamycin G (1), which is a derivative of the known antiparasitic compound Paenidigyamycin A (2). Compound (1) was isolated on HPLC at tR ≈ 37.5 min and its structure determined by IR, UV, MS, 1D, and 2D-NMR data. Compound 1 produced weak to moderate antileishmanial and antitrypanosomal activity when tested against Leishmania donovani (Laveran and Mesnil) Ross (D10) and Trypanosoma brucei subsp. brucei strain GUTat 3.1 with IC50 = 115.41 and 28.75 µM, respectively. This result is interesting since the parent compound 2 is known to possess consistent and potent antiparasitic activity. However, 1 displayed a promising selectivity profile towards T. brucei subsp. brucei due to its relatively low toxicity against normal mouse macrophages RAW 264.7 cells (SI = 8.70). Given that compound 1 is also the main metabolite found in the hexane fraction of all extracts produced by Paenibacillus sp. DE2SH when it is co-cultured with other bacteria strains, it must possess some unique biological functions which should make it an excellent candidate for further biological activity screening in other bioassays.
AtıfScopus4WoS3OpenAlex4İncele - Derleme MakaleAçık Erişim2019Scopus SJRQ2Evaluation of X-ray tomography contrast agents: A review of production, protocols, and biological applications
Koç, Mümin Mehmet; Aslan, Naim; Kao, Alexander P.; Barber, Asa H.
X-ray computed tomography is a strong tool that finds many applications both in medical applications and in the investigation of biological and nonbiological samples. In the clinics, X-ray tomography is widely used for diagnostic purposes whose three-dimensional imaging in high resolution helps physicians to obtain detailed image of investigated regions. Researchers in biological sciences and engineering use X-ray tomography because it is a nondestructive method to assess the structure of their samples. In both medical and biological applications, visualization of soft tissues and structures requires special treatment, in which special contrast agents are used. In this detailed report, molecule-based and nanoparticle-based contrast agents used in biological applications to enhance the image quality were compiled and reported. Special contrast agent applications and protocols to enhance the contrast for the biological applications and works to develop nanoparticle contrast agents to enhance the contrast for targeted drug delivery and general imaging applications were also assessed and listed.
AtıfScopus91OpenAlex101İncele - MakaleYalnız künye2019Scopus SJRQ2Intergenerational transmission of traditional practices at newborn care: An explorative study NEWBORN CARE
Baş, Nazan Gürarslan; Karatay, Gülnaz; Arıkan, Duygu; Baş, Kazım
The study was conducted to reveal the cultural practices used in neonatal care as well as revealing the intergenerational transmission of these practices. This comparative and descriptive study was conducted between December 2015 and June 2016. The study sample consisted of 210 mothers, including 130 grandmothers and 80 mothers. Data was collected by the researchers with the face-to-face interviews with the mothers and analyzed by percentile and frequency. It was observed that 77.0% of the grandmothers cover the baby's face with yellow cloth for treating jaundice, 86.2% of them use olive oil for the infantile seborrhoeic dermatitis, 57.8% use breast's milk for thrush, 50.8% use powder to treat diaper rash, and 36.5% use fine-textured soil (höllük) for the treatment of diaper rash. 70.4% of the mothers were covering the baby's face with yellow cloth for treating jaundice, 77.8% were using olive oil for the dandruff (infantile seborrhoeic dermatitis) treatment, 37.8% were using breast's milk for thrush, and 57.7% were using medical cream for the treatment of diaper rash. According to the results of the study, even though the use of non-rational cultural health practices in neonatal care decreases, it is observed that their importance still remains.
AtıfScopus2İncele - MakaleYalnız künye2019Scopus SJRQ2Silver/Selenium/Chitosan-doped Hydroxyapatite coatings on biological NiTi alloy: In vitro biodegradation analysis
Say, Y.; Aksakal, B.
Abstract: Nitinol (NiTi) substrates were bioceramic coated by single layer Hydroxyapatite (HA), double layer HA/Silver (Ag) and double-layered HA/Selenium (Se)–Chitosan (Cht) substitutions by sol–gel method. Surface morphologies and adhesion strengths of the obtained coatings were characterized by means of SEM, EDX, XRD, and adhesion tests. Crack-free coatings were obtained in single layer-HA (S1), double layer HA/Ag (S2), and double-layered HA/Selenium–Cht (S3) coatings on NiTi alloys executed via the sol–gel method. Degradation behavior was analyzed in via simulated body fluid (SBF) environment by means of weight loss (%) and ion release rates for 1–4 weeks of immersion periods. The degraded coating particles were measured and metallic ions were detected quantitatively by an inductively coupled plasma–mass spectrometer (ICP–MS). The results show that such coatings could minimize and/or prevent the degradation of metallic ions and weight loss (%) from the coated substrates. From the overall results, HA/Ag double layer biocomposite (S2)-coated NiTi substrates revealed the highest adhesion strength and lowest weight loss and degradation. It was also shown in all groups that the Ni ion release from the NiTi substrates was prevented by the coatings. [Figure not available: see fulltext.].
AtıfScopus10WoS9OpenAlex11İncele - MakaleYalnız künye2019Scopus SJRQ2Structural, optical, and gamma-ray-sensing characterization of (35 − x) PbO–10 MgO–10Na2O–5 Fe2O3–10 BaO–(30 − x) B2O3 glasses
Kumar, Ashok; Ali, Atif Mossad; Sayyed, M.I.; Aşkın, A.; Rashad, M.; Algarni, H.
Amorphous PbO–MgO–Na2O–Fe2O3–BaO–B2O3 glass system has been prepared. FTIR spectra studied in the range of 400–1600 cm−1 which gives information regarding the different structural, vibration bonds. To study the various optical parameters, the UV absorption spectra are studied in the range 190–1100 nm. The photon attenuation characteristics for the current samples were studied using Geant4 simulation code. The transmission fraction (T) was calculated and the results showed that the addition of PbO decreases the values of T. For the samples which contain 55 mol% and 35 mol% of PbO, the T values are, respectively, 0.065 and 0.161 at 356 keV. High atomic number and high of lead result in lower half-value layer values for Pb55B10 glass compared to the Pb35B30 sample which has the lowest amount of Pb in its structure. At 356 keV, the tenth value layer values are 2.521 and 1.685 cm for the samples coded as Pb35B30 and Pb55B10, respectively. From the radiation-shielding parameter results, the use of high-density glasses against the penetrating gamma rays provides a better shielding performance using thinner glass layer.
AtıfScopus17OpenAlex16İncele - MakaleYalnız künye2019Scopus SJRQ2Experimental damage evaluation of prototype infill wall based on forced vibration test
Onat, Onur
This paper aims to investigate vibration frequency decrease (vibration period elongation) of reinforced concrete (RC) structure with unreinforced infill wall and reinforced infill wall exposed to progressively increased artificial earthquake load on shaking table. For this purpose, two shaking table experiments were selected as a case study. Shaking table experiments were carried on 1:1 scaled prototype one bay one storey RC structure with infill walls. The purpose of this shaking table experiment sequence is to assess local behavior and progressive collapse mechanism. Frequency decrease and eigen-vector evolution are directly related to in-plane and out-of-plane bearing capacities of infill wall enclosure with reinforced concrete frame. Firstly, frequency decrease-damage relationship was evaluated on the base of experiment results. Then, frequency decrease and stiffness degradation were evaluated with applied Peak Ground Acceleration (PGA) by considering strength deterioration. Lastly, eigenvector evolution-local damage and eigenvector evolution-frequency decrease relationship was investigated. Five modes were considered while evaluating damage and frequency decrease of the tested specimens. The relationship between frequency decrease, stiffness degradation and damage level were presented while comparing with Unreinforced Brick Infill (URB) and Reinforced Infill wall with Bed Joint Reinforcement (BJR) on the base of natural vibration frequency.
AtıfScopus14WoS12OpenAlex9İncele - MakaleAçık Erişim2019Scopus SJRQ1A study on the technological pedagogical contextual knowledge of science teacher candidates across different years of study
Karakaya Cirit, Didem; Canpolat, Erdal
This case study survey investigates the Technological Pedagogical Contextual Knowledge (TPCK) of Science Teacher Candidates (STC) across different years of study in the Topic of Renewable Energy (TRE). In line with the transformative model, the study treats TRE-TPCK as a new knowledge domain emerging from the interaction between content, technology, pedagogy and contextual knowledge. Participants were 36 Science Education students who were in their 1st, 2nd, 3rd and 4th years of study during the 2014–2015 academic year. Teacher candidates’ TPCK was identified through semi-structured interviews based on (1) Vignettes, (2) Anecdotes from a teacher named Zeynep and the (3) Content Presentation Technique (CPT). The data were analyzed by using the content analysis technique. The findings showed that the TRE-TPCK of teacher candidates across different years of study was at a similar and less-than-ideal level. STCs in different years of study mostly disregarded the macro and meso contexts when teaching the topic of renewable energy and were partially competent in the sub-meso, micro and sub-micro contexts. They particularly lacked technology-integrated evaluation knowledge when teaching TRE.
AtıfScopus8WoS8OpenAlex10İncele - MakaleAçık Erişim2019Scopus SJRQ2Effect of MgO,Al2O3 and FeCr2O4 on microstructure and wear resistance of Babbitt metal (Sn-Sb-Cu)
Tasgin, Yahya
In this study, the Sn-Sb-Cu alloy known as Babbitt metal and used as the coating material for the screw die surface of the journal bearings of the hydroelectric plants was reinforced with magnesium oxide (MgO), aluminium oxide (Al2O3) and ferrochromium (FeCr2O4) in order to ensure more efficient use of this alloy, formation were examined. The Babbitt prevent contact of the surface of the coating alloy with each other by acting as a separating oil layer having a 150 bar pressure. It is desired that the coating surface both resists against the high pressure applied and some part of the coating surface is asked to prevent from separating the surface of screw die as a result of high speed rotational motion and thus, damaging the shaft. Then, it was aimed to determine the wear resistance of the material as coating and the effects of the added%10 MgO,%10 Al2O3 and%10 FeCr2O4 on wear of material. As a result of the assessments carried out, it was suggested that the wear resistance of the coating would increase when the compound of Al2O3 was added into Babbitt metal. Purpose of the article used as coating material of babbitt metal, being investigated how to exert strong posture affected, under high pressure.
AtıfScopus8WoS7OpenAlex7İncele - MakaleAçık Erişim2019Scopus SJRQ3The effects of deposition potential on the optical, morphological and mechanical properties of DLC films produced by electrochemical deposition technique at low voltages
Aslan, Naim; Başman, Necati; Uzun, Orhan; Erkovan, Mustafa; Yakuphanoǧlu, Fahrettin
Diamond-like carbon (DLC) films were electrochemically deposited onto indium tin oxide (ITO) substrates using acetic acid and deionized water as electrolyte at low deposition voltages (2.4 V and 60 V). The transmittance of the films was investigated by UV spectrometry. Transmittance measurements versus wavelength revealed that the films transmit 86 % to 89 % light in visible region and band gap of the films varies between 3.87 eV and 3.89 eV. Atomic force microscopy (AFM) and scanning electron microscopy (SEM) were used for structural characterization to evaluate surface morphology of the DLC films. The grain size and the surface roughness increased for the films prepared at higher deposition potential, while their measured average height decreased. The mechanical properties (hardness H and elastic modulus Er) were determined from load-displacement curves which were obtained by using nanoindentation method. Hardness and elastic modulus of the films increased as the deposition voltage of the films increased from 2.4 V to 60 V.
AtıfScopus9OpenAlex4İncele - MakaleYalnız künye2019Scopus SJRQ2Investigation of the anti-apoptotic activity of ozone therapy in rainbow trout macrophages infected with Yersinia ruckeri
Küçükgül, Azime; Küçükgül, Altuğ; Gönenci, Ramazan; Özsoy, Şule Yurdagül; Kutlu, Banu; Işgör, Mehmet Mustafa
Yersinia ruckeri is the causal agent of enteric redmouth (ERM) in trout. This study aimed to investigate the effectiveness of nontoxic ozone on Y. ruckeri-infected trout cells in in vitro conditions. Rainbow trout macrophages (RTS-11) were exposed to Y. ruckeri for 24 h after being incubated with the ozonized medium at nontoxic concentration. Effective concentrations of nontoxic ozone (3 gamma) and bacteria (1.5 x 108 cfu/mL) were determined by viability tests. The expression of caspases 1, 3, 8, and 12 was determined by real-time PCR and protein levels investigated by ELISA method. Apoptotic-necrotic cell ratios were determined by acridine orange and ethidium bromide staining. Bacterial stimulations of caspases (1, 3, 8, and 12) were suppressed by ozone mostly at the translational level. While bacterial infection increased the count of apoptotic and necrotic cells at different stages, ozone significantly reduced this condition. Obtained data indicate possible use of nontoxic ozone as a safe and effective treatment alternative for increasing host defenses and eliminating the infection in the case of yersiniosis in fish.
AtıfWoS1OpenAlex3İncele - MakaleYalnız künye2019Scopus SJRQ3Application of deep transfer learning for automated brain abnormality classification using MR images
Talo, Muhammed; Baloglu, Ulas Baran; Yıldırım, Özal; Rajendra Acharya, U.
Magnetic resonance imaging (MRI) is the most common imaging technique used to detect abnormal brain tumors. Traditionally, MRI images are analyzed manually by radiologists to detect the abnormal conditions in the brain. Manual interpretation of huge volume of images is time consuming and difficult. Hence, computer-based detection helps in accurate and fast diagnosis. In this study, we proposed an approach that uses deep transfer learning to automatically classify normal and abnormal brain MR images. Convolutional neural network (CNN) based ResNet34 model is used as a deep learning model. We have used current deep learning techniques such as data augmentation, optimal learning rate finder and fine-tuning to train the model. The proposed model achieved 5-fold classification accuracy of 100% on 613 MR images. Our developed system is ready to test on huge database and can assist the radiologists in their daily screening of MR images.
AtıfScopus473OpenAlex508İncele - BildiriAçık Erişim2019Predicting Collaboration Relationships on Social Network
Aslan, Serpil; Kaya, Buket; Varol, A.; Yazici, A.; Yazici, M.A.; Varol, C.; Aygunes, G.S.; Cotur, A.
Scientific papers are mostly performed by collaboration between research groups. Researchers work in various subjects and in several research areas. Therefore, identifying a strong research group is a quite complex task. To cope with this complex task, we propose a network-based method that predicts the best appropriate collaborations for researchers in a co-authorship network. In this paper, we have constructed a weighted co-authorship network by using a real database of scientific papers. Almost all of the methods in this area use the unweighted network model. But, weighted networks are particularly important when representing the network-based properties. The constructed network consists of nodes and links which represent respectively authors and their collaborations. In these networks, if two researchers are the common authors in the same paper, they are considered connected. Typically, the link weights represent the number of papers that two authors have made collaboratively. We also use local LCP-based algorithms to calculate the betweenness and closeness of the authors in this paper. The experimental results demonstrate the success of the proposed method.
AtıfScopus3OpenAlex2İncele