Yazarlar
- Alayunt, Naci O.(2)
- Ates, M.(2)
- Karagozoglu, Yusuf(2)
- Parlak, Akif E.(2)
- Turkoglu, Semra(2)
- Yildirim, Numan(2)
- Yildirim, Nuran Cikcikoglu(2)
- Alp, A.(1)
- Arslan, A.(1)
- Arslan, Z.(1)
- Bekler, F. Matpan(1)
- Danabas, D.(1)
- Demir, V.(1)
- Demirol, F.(1)
- Dikici, A.(1)
- Dugo, M. A.(1)
- Gulec, A. Kucukgul(1)
- Gündüz, F.(1)
- Ince, Olcay Kaplan(1)
- Kucukgul, A.(1)
- Paksoy, Mehmet Yavuz(1)
- Sahilli, Y. C.(1)
- Seker, E.(1)
- Serdar, O.(1)
- Tchounwou, P. B.(1)
- Türkoglu, Semra(1)
- Ural, M.(1)
- Yildirim, Isil(1)
- Yildirim, N.(1)
- Yildirim, N. Cikcikoglu(1)
- Yilmaz, E.(1)
- Yuce, Ebru(1)
- Yönten, Vahap(1)
- Yüksel, F.(1)
- Çoban, M. Zulfu(1)
Yayınlar
- MakaleYalnız künye2018Scopus SJRQ3SYNTHESIZING, CHITOSAN COATING AND DETECTING THE NANOTOXIC EFFECT OF THE LEAD SELENIDE (PbSe) QUANTUM DOTS
Yilmaz, E.; Ates, M.; Sahilli, Y. C.
Researches on nano-structured materials (<100 nm) are increasing rapidly in the direction of technological developments. Synthesis and modification of quantum dots, known as nanomaterials and nanocrystals, have become an important aspect of nanotechnology. The reason for this is that it has many potential applications in the field, including biomedicine and pharmacology. The unique properties and biological effects of nanostructured particles indicate that they can potentially be used as an alternative in the treatment of various diseases. In this work, PbSe quantum dots were synthesized by chemical method and modified by chitosan coating. The characterization of PbSe was done by TEM, SEM, XRD, DLS and Zeta potential analysis methods. When the morphological structures of the quantum dots obtained by chemical synthesis were examined, round and spherical nano-sized particles (<20 nm) of all PbSe were obtained according to TEM and SEM results. It has been seen that PbSe quantum dots have a positive (+) surface charge and are highly stable (40 + mV). In addition, the increase in oxidation resistance of PbSe coated with chitosan was found in XRD results. As a result of this research, small size and biopolymer coated and thus more stable quantum dots could be obtained. It has also been found that PbSe quantum dots coated with biopolymers like chitosan may have the potential to be used in pharmacology and biomedical applications.
- MakaleYalnız künye2014Scopus SJRQ2EFFECT OF COPPER OXIDE NANOPARTICLES TO SHEEPSHEAD MINNOW (CYPRINODON VARIEGATUS) AT DIFFERENT SALINITIES
Ates, M.; Dugo, M. A.; Demir, V.; Arslan, Z.; Tchounwou, P. B.
Nanotechnologies research has become a significant priority worldwide. Many engineered nano-sized materials have been increasingly used in consumer products. But the adverse effects of these nanoparticles on the environment and organisms have recently drawn much attention. The present study investigated the effects of different concentrations of copper oxide nanoparticles (CuO NPs) on the sheepshead minnow (Cyprinodon variegatus) at different salinity regimes, since it is able to withstand a wide range of salinities. The results indicated that CuO NPs could cause behavioral changes in the fish, such as increased mucus secretion, less general activity and loss of equilibrium. No mortality was observed at the presence of CuO NPs during the experiments. But higher oxidative stress was determined at half strength seawater than seawater exposure medium, which can be associated with the decreasing toxicity of CuO NPs as salinity increases. In addition, Cu contents in the tissues of the fish were significantly higher (p<0.05) in the low salinity. The order of Cu accumulation in the fish's organs was intestine > gills > liver.
AtıfWoS25
İncele - MakaleYalnız künye2014Scopus SJRQ2ESTIMATION OF THE POPULATION SIZE OF CAPOETA UMBLA (HECKEL, 1843) IN THE LAKE HAZAR (ELAZIG) BY REMOVAL METHOD
Yüksel, F.; Alp, A.; Gündüz, F.; Çoban, M. Zulfu; Demirol, F.
Fish populations in smaller aquatic environments are affected by the fishing pressure at a much faster pace. Often, compensation of this effect either takes a long time or is not possible at all. For the purposes of establishing fishing regulations in these water environments, the removal method is able to provide results quickly and almost accurately. The Lake Hazar, which is the environment of our study, is 8,600 hectares in size, and is a natural lake where Capoeta umbla species is caught commercially using gill nets. In this study, stock size of Capoeta umbla in the Lake Hazar (Elazig) was estimated using removal method. In addition, the power of fishing and the status of fishing yield in the lake were evaluated. In our research, it was determined that seven commercial fishing boats caught 25,721 kg of fish in the lake in a fishing season. CPUE was calculated as 1.55 kg (kg/day/a gill net). As a result of the regression analysis, the amount of stock in the lake was the estimated to be 37,781 kg (+/- 14,001 kg). When cumulative catch was formulated as recommended by Ricker (1975), the population size was estimated to be 38,649 kg (+/- 15,007 kg). As a result of our study, the use of removal method was found to be appropriate for small reservoirs with reduced population density due to strong fishing pressure.
AtıfWoS1İncele - MakaleYalnız künye2014Scopus SJRQ2THE EFFECTS HYDROXYUREA DERIVATIVE SCHIFF BASES ON FATTY ACIDS AND LYPOPHILIC VITAMINS IN LIVER OF RATS
Turkoglu, Semra; Parlak, Akif E.; Yildirim, Isil; Karagozoglu, Yusuf; Alayunt, Naci O.
Schiff bases and their metal complexes have antiviral, antimicrobial, antitumoral, radical scavenging and antioxidant activities. In this study, effects of Schiff base ligand and its metal complexes on the fatty acids and lyphophlilic vitamins of the liver of rats were investigated. The fatty acids of the liver were determined by GC and lyphophlilic vitamins of the liver determined by HPLC. The amounts of stearic acid (18:0), oleic acid (18:1) and monounsaturated fatty acids (MUFA) considerably decreased in the Mn, Ni and Zn complexes groups, whereas the amount of linolenic acid (18:3) and eicosatrienoic acid (20:3) considerably increased in the Ni an Zn complexes groups compared to the control group (P<0.01). However, there was no significant difference (P>0.05) in the amounts of arachidonic acid (20:4), docosahexaenoic acid (22:6), total saturated fatty acids (SFA) and polyunsaturated fatty acids (PUFA), total omega-3 and omega-6 fatty acids between groups. The amounts of vitamin K-1, vitamin D-2 considerably increased (P<0.05) in the Mn and Ni complexes groups as compared to the control. It was observed that the amount of a-tocopherol increased both in the Ni and Co complexes groups when compared to the control group but this increase was parallel to the amount in the same groups (P<0.05). As a result, it can be think that with the application of toxic metals such as manganese, cupper, nickel, cobalt, and zinc unsaturated fatty acids affected the activities of enzymes which are in the liver tissue and in charge in the fatty acid chain elongation.
AtıfWoS1İncele - MakaleYalnız künye2013Scopus SJRQ2TOTAL ANTIOXIDANT STATUS AND ANTIFUNGAL ACTIVITIES OF ENDEMIC GEOPHYTIC PLANTS COLLECTED FROM MUNZUR VALLEY IN TUNCELI, TURKEY
Yildirim, Nuran Cikcikoglu; Paksoy, Mehmet Yavuz; Yuce, Ebru; Yildirim, Numan
Total antioxidant status and antifungal activities of three endemic plants from the Munzur Valley in Tunceli, Turkey; Bellevalia gracilis Feinbrun, Muscari aucheri (Boiss.) Baker ve Tulipa armena Boiss. var. lycica (Baker) Marais were evaluated for the first time. Aqueous, hexanic, methanolic and ethanolic extracts were obtained from leaves and bulbs of B. gracilis, M. aucheri ve T. armena var. lycica. Total antioxidant status was determined by using TAS assay kit (Rel assay diagnostics). Antifungal assays were performed according to amended agar method against white rot fungus Coriolus versicolor. Among the plants tested, the leaves of B. gracilis exhibited highest total antioxidant status among all samples evaluated in this study. According to the results, M. aucheri plant exhibited the lowest antioxidant status. The results of this study showed that the aqueous leaf extract of T. armena var. lycica at a concentration 2.5% (w/v) suppressed significantly the radial growth of C. versicolor by 68.00%. It can be concluded that the plant species assayed possess antifungal and antioxidant properties.
AtıfWoS4İncele - MakaleYalnız künye2013Scopus SJRQ2THERAPEUTIC EFFECTS OF THYME (THYMUS VULGARIS LINNEAUS) AND FENNEL (FOENICULUM VULGARE MILLER) ESSENTIAL OILS IN INFECTED RAINBOW TROUT, ONCORHYNCHUS MYKISS (WALBAUM)
Gulec, A. Kucukgul; Kucukgul, A.; Danabas, D.; Ural, M.; Seker, E.; Arslan, A.; Serdar, O.
The fish (84 +/- 1.02 g mean +/- SEM) were divided into 3 groups (N=15 in each group) as control (CNT), infected with Yersinia ruckeri (INF), and infected and essential oils (+EO). The CNT and INF groups were fed only with commercial fish feed. The +EO group was fed with feeds prepared with the rate of 10 ml herbal essential oils (mixed thyme and fennel) / 100 g feed during 21 days. The liver tissue (0.4 g) of fish was dissected in third day of the experimental period and mRNA transcription levels in liver tissue were determined by Real Time PCR analysis. INF and +EO groups exhibited decreased immunity against the challenging with Y. ruckeri infection (53.57 and 42.85 % mortality, respectively) when compared with CNT group (93.33 %). Gene mRNA transcription levels of tumour necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), inducible nitric oxide synthesis (iNOS), serum amyloid A (SAA), that are responsible during the initiation and continuation of the inflammation increased in 1.86, 2.46, 1.62 and 55.7 fold change, respectively in INF group, whereas mRNA expressions of haptoglobin (Hp) decreased (1.2-fold change) in 3th day of experimental period. The +EO group eliminated the increase in all of the gene expressions.
AtıfWoS7İncele - MakaleYalnız künye2013Scopus SJRQ2DETECTING OPTIMUM AND COST-EFFICIENT OF MICROBIAL GROWTH RATE AND LACTOSE CONSUMPTION OF KLUYVEROMYCES LACTIS Y-8279 USING RSM
Yönten, Vahap
Exploring optimum and cost-efficient medium composition for microbial growth rate and lactose consumption of Kluyveromyces Lactis Y-8279 yeast culture growing on whey was studied by applying a multi-step response surface methodology (RSM). RSM is a combination of Plackett Burman (PB), Steepest-Ascent (SA) and Central Composite Design (CCD) Medium temperature, pH, yeast extract and lactose concentrations were evaluated the most effective operational factors through seven factors by applying PBD. These four factors were selected for SA program and SA experiments were carried out to find approximately maximum microbial concentration with lactose, pH, yeast extract and medium temperature. Then CCD was carried out with these factors (lactose, medium temperature, pH and yeast extract). Based on ANOVA test the optimum operational conditions of maximum growth rate were obtained as 18.8 g/L, 0.94 g/L, 5.2 and 27 degrees C, lactose concentration, yeast extract concentration, pH, and medium temperature, respectively. And then optimum operational conditions of lactose consumption were obtained as 13 g/L, 0.91 g/L, 8 and 27.5 degrees C, lactose concentration, yeast extract concentration, pH, and medium temperature, respectively too.
AtıfWoS1İncele - MakaleYalnız künye2013Scopus SJRQ2THE EFFECTS OF HYDROXYUREA DERIVATIVE 1, 3, 4-THIADIAZOLES ON SERUM BIOCHEMICAL PARAMETERS AND ANTIOXIDANT STATUS IN LIVER OF RATS
Karagozoglu, Yusuf; Türkoglu, Semra; Parlak, Akif E.; Alayunt, Naci O.
In this study, it was aimed to investigate the antioxidant and antihepatotoxic effect of hydoxyurea derivative 1,3,4-thiadiazoles on serum biochemical parameters (AST, ALT, LDH, urea, creatinine and total bilirubin) and antioxidant parameters (SOD, CAT, GPX, MDA). In our study, a total of 35 adult male wistar rats were divided into 5 equal groups. DMSO diluted with only corn oil, was injected to the control group. 25 mg/kg ligand, 25 mg/kg thiadiazole-manganese, 25 mg/kg thiadiazole-cadmium and 25 mg/kg thiadiazole-chrome complexes was injected to the experimental groups rats subcutaneously for 15 days with three-day interval during the test. After blood samples were centrifuged AST, ALT, LDH enzyme activites hepatic injury; and then, the activites of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and the level of malondialdehyde (MDA) in liver tissues were determined spectrophotometrically. The level of AST was found to be lower (p<0.05) in the Cr-L group than in other groups. The levels of ALT and total bilirubine were found to be lower (p<0.05) in the Cd-L group than in other groups. The level of SOD was found to be higher (p<0.05) in the Cd-L group than in other groups. The levels of GPX was found to be lower (p<0.05) in the Cr-L group than in other groups. As a result, it can be concluded that their pharmacological characteristics can be beneficial in many fields of application because hydroxyurea derivative 1,3,4 thiadiazole compounds show the antioxidant and antihepatotoxic activity.
AtıfWoS1İncele - MakaleYalnız künye2012Scopus SJRQ2ANTIOXIDANT PROPERTIES OF WILD EDIBLE MUSHROOM PLEUROTUS ERYNGII COLLECTED FROM TUNCELI PROVINCE OF TURKEY
Yildirim, Nuran Cikcikoglu; Turkoglu, Semra; Yildirim, Numan; Ince, Olcay Kaplan
Antioxidants are our first line of defense against free radical damage, and are critical for maintaining health. The need for antioxidants becomes even more critical with increased exposure to free radicals. In the past few years there has been an increasing interest in determining relevant dietary sources of antioxidant phenolics. Mushrooms have been not only used as food materials with their unique flavor and texture, but also recognized as an important source of biologically active compound of medicinal value. In our study, to determine the antioxidant properties of the methanolic extracts of Pleurotus eryngii strains collected from different region of Tunceli, radical scavenging activity, total phenolic contents, reducing power, metal chelating activity and total antioxidant status (TAS) were analyzed. The analysis of phenolic compounds was performed by HPLC. In particular, the methanolic extract of P. eryngii collected from city center revealed the highest DPPH radical scavenging activity and reducing power, while the highest total phenolics and total antioxidant status was determined in P. eryngii collected from Pulumur. P. eryngii collected from Ovacik showed the highest chelating effects. Concentration of phenolic compounds found in three wild edible mushrooms. Kaempferol and catechin were not determined in musrooms species. The highest rutin levels were determined in ovacik. Resveratrol was determined only in Pulumur. The studied wild mushrooms might be beneficial to protect human body against oxidative damage.
AtıfWoS40İncele - MakaleYalnız künye2010Scopus SJRQ2IN VITRO ANTIMICROBIAL EVALUATION OF COMMERCIAL TEA EXTRACTS AGAINST SOME PATHOGEN FUNGI AND BACTERIA
Yildirim, N.; Bekler, F. Matpan; Yildirim, N. Cikcikoglu; Dikici, A.
The in vitro antimicrobial activity of crude ethanol, methanol, hexane and aqueous extracts of commercial tea types such as fennel (Foeniculum sp.), senna (Cassia sp.), basilrosemary (Ocimum sp.-Rosmarinus sp), daisy (Bellis sp.) and sage (Salvia sp) against pathogen fungi (Colletotrichum coccodes, Epicoccum nigrum, Scopulariopsis brevicaulis) and foodborne pathogen bacteria (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Bacillus cereus, Klebsiella pneumoniae, Enterobacter sp.) were investigated with disk diffusion method. Senna (Cassia sp.) exhibed the most effective antimicrobial activity in both ethanolic and methanolic extracts. The best antimicrobial effect (30.6 mm) against E. nigrium was seen in methanolic senna (Cassia sp.) extract. The results of the study indicate that commercial tea types have showed various levels of antimicrobial activity depend on the type of solvent used in the extraction procedure.
AtıfWoS5İncele - DergiDIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES