Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Erten, Fusun(3)
- Sahin, Kazim(2)
- Sengur, Abdulkadir(2)
- Uyanik, Hakan(2)
- Özçelik, Salih Taha Alperen(2)
- Akkoyun, Hurrem Turan(1)
- Akkoyun, Mahire Bayramoğlu(1)
- Arihan, Okan(1)
- Atçalı, Tuğçe(1)
- Aydın, Sevinç(1)
- Baykara, Murat(1)
- Bengü, Aydın Şükrü(1)
- Birinci, Ceyhun Birinci(1)
- Demir, Halit(1)
- Er, Besir(1)
- Erisir, Mine(1)
- Gencoglu, Hasan(1)
- Guler, Osman(1)
- Güler, Osman(1)
- Karadag, Abdullah(1)
- Karakaş, Buğra(1)
- Kubulay, Banu(1)
- Küçükgül, Altuğ(1)
- Küçükgül, Azime(1)
- Türk, Ahmet(1)
- Zencirci, Büşra(1)
- Özay, Yusuf(1)
- Özçelik, Mehtap(1)
- Üzen, Hüseyin(1)
Yayınlar
- MakaleAçık Erişim2024Convmixer ve SDD Kullanılarak DEHB Hastalığının EEG Sinyalleri ile Otomatik Olarak Tespit Edilmesi
Sengur, Abdulkadir; Üzen, Hüseyin; Özçelik, Salih Taha Alperen; Uyanik, Hakan; Karakaş, Buğra
DEHB, çocuklarda dikkat eksikliği, davranış problemleri, eğitimle ilgili sorunlar ve düşük özgüven gibi problemler oluşturabilir. Bu çalışma, Dikkat Eksikliği Hiperaktivite Bozukluğu (DEHB) teşhisini elektroensefalografi (EEG) sinyalleriyle değerlendirmeyi hedefleyen bir araştırmayı özetlemektedir. Araştırma, 30 DEHB tanısı almış çocuk ve 30 sağlıklı kontrol grubunun EEG verilerini kullanmıştır. EEG verileri öncelikle gürültü azaltma amacıyla işlenmiş ve ardından ConvMixer, ResNet50 ve ResNet18 gibi derin öğrenme modelleri kullanılarak sınıflandırılmıştır. Bulgular, ConvMixer'in düşük hesaplama kaynaklarına ihtiyaç duyarak yüksek sınıflandırma başarısı elde ettiğini göstermektedir. Ayrıca, EEG sinyallerinin DEHB teşhisinde kullanılabilirliği konusunda farklı kanalların etkileri incelenmiş ve T8 kanalının özellikle etkili olduğu tespit edilmiştir. Bu çalışma, EEG tabanlı DEHB teşhisi için daha hafif modellerin kullanılabilirliğini ve EEG kanallarının önemini vurgulamaktadır.
AtıfOpenAlex1
İncele - MakaleAçık Erişim2023Balistokardiyografi sinyalleri ile derin öğrenme tabanlı hipertansiyon tespiti
Sengur, Abdulkadir; Özçelik, Salih Taha Alperen; Uyanik, Hakan
Kan basıncı, damarlardaki kanın damar duvarlarına uyguladığı basınçtır. Bu basınç değerinin normal kabul edilen seviyelerin üzerinde seyir etmesi yüksek tansiyon (YT) veya hipertansiyon (HPT) olarak bilinir. Hayat kalitesini negatif yönde etkileyen, çoğu zaman organlarda çeşitli tahribatlara sebep olan ve ölümlere yol açabilen bu sağlık probleminin teşhisi oldukça önemlidir. Bu çalışmada, balistokardiyografi (BKG) sinyalleri kullanılarak HPT'nin otomatik teşhisine yönelik bir yöntem önerilmiştir. Bunun için BKG sinyalleri, sürekli dalgacık dönüşümü filtre bankası (SDDFB) yöntemi kullanılarak zaman-frekans domenine taşınmıştır. Bu işlemler yapılırken kullanılan dönüşüm yönteminde bazı parametre ayarları gerçekleştirilerek dönüşümün kalitesi arttırılmıştır. Daha sonra elde edilen görüntüler ResNet18, ResNet50, VGG16 ve AlexNet evrişimsel sinir ağlarıyla sınıflandırılmış ve elde edilen sonuçlar karşılaştırılmıştır. Önerilen yöntem ile ResNet18, ResNet50, VGG16 ve AlexNet mimarileri için sırasıyla %98,92, %99,34 ve %99,22 ve %98,07 sınıflandırma doğruluğu elde etmiştir. Elde edilen bu yüksek sınıflandırma sonuçları önerilen yöntemin hipertansiyon teşhisi için kullanılabileceğini ispatlar niteliktedir.
- MakaleAçık Erişim2023Investigation of the Effects of Ghrelin and Kisspeptin Levels in Liver Tissue of Rats Fed with High Fructose Diet -A Histological Study
Özay, Yusuf; Güler, Osman; Türk, Ahmet; Karadag, Abdullah; Zencirci, Büşra
Purpose: High fructose corn syrup (HFCS) is used commonly in the food industry and has been associated with various diseases including obesity, diabetes and fatty liver. Ghrelin, an orexigenic hormone with widespread receptors in many tissues, exerts various central and peripheral effects. Food intake may reduce its synthesis. Kisspeptin plays a major role in reproductive hormones and its receptors are expressed in tissues with high metabolic activity, such as the liver. This study aims to investigate the effects of HFCS consumption on liver tissue and its relationship with Kisspeptin and Ghrelin levels. Materials and Methods: Fourteen adult male Wistar albino rats, aged eight to ten weeks, were used in this study and divided into two groups; Control and HFCS (n=7). Tumor Necrosis Factor-alpha (TNF-α), Ghrelin, and Kisspeptin levels in the liver tissues of the rats were measured using an immunohistochemical method and subsequently analyzed through histoscoring. Results: Our data revealed a significant increase in Kisspeptin, Caspase 3, and TNF-α levels and a decrease in Ghrelin levels in the HFCS group compared to the Control group. Conclusion: In conclusion, our study demonstrates, for the first time, changes in liver Kisspeptin levels induced by a high fructose diet. Furthermore, the consumption of HFCS in food led to inflammatory activation, tissue damage, and reduced Ghrelin levels.
- MakaleYalnız künye2022Effects of Maca Root Extract on Some Molecular Parameters of Kidney Tissue in Rats Fed a High-Fat Diet
Erten, Fusun
Maca (Lepidium meyenii) has been used as a dietary supplement in ethnomedicine for centuries.\rMaca has recently become a high-functional food globally, due to its numerous biological benefits.\rThe high-fat diet (HFD) is closely related to the occurrence of obesity. Obesity is a common cause\rfor chronic kidney disease. The aim of this study was to investigate the effects of maca on organic\ranion transporters-3 (OAT-3), organic cation transporter-1 (OCT-1), organic cation transporter-2\r(OCT-2), insulin receptor substrate-1(IRS-1), vascular adhesion molecule-1 (VCAM-1) and\rvascular endothelial growth factor (VEGF) protein levels. In the study, 28 Sprague-Dawley male\rrats were randomly allocated into four groups (n=7); i) Control group (fed with standard diet); ii)\rGroup fed with standard diet and supplemented with Maca (40mg/kg/day) group; iii) Group fed a\rHFD; iv) Group fed with Maca+HFD. After the 60-day of study, kidney OCT-1, OCT-2 and IRS-1\rprotein levels showed a significant increase in the HFD+Maca treated group compared to the HFD\rgroup (P<0.05). Renal OAT-3 level was found to be significantly lower in the HFD group compared\rto the control group (P<0.0001). In addition, a significant decrease in VCAM-1 and VEGF protein\rlevels was observed in the HFD+Maca group compared to the HFD group (P<0.0001). These\rresults show the protective and regulatory activity in the Maca's kidney tissue when both normally\rand the HFD diet is fed
- MakaleYalnız künye2022Effect of Lutein/Zeaxanthin Isomers on the Musclin Signaling Pathway
Sahin, Kazim; Er, Besir; Erten, Fusun
Lutein (L) and zeaxanthin (Zi) are plant origin carotenoids. They have anti-inflammatory and\rantioxidant effects. Musclin is a myokine induced by physical activity. The aim of this study was to\rinvestigate the effect of L/Zi supplementation on serum and skeletal muscle musclin levels in rats\rsubjected to physical exercise. For this purpose, the rats were divided into four groups, each\rconsisting of seven rats, as the control group, no exercise, L/Zi treated and no exercise group\r(L/Zi), exercise group (E), and L/Zi treated and exercise group (E + L/Zi treatment). L/Zi was\radministered daily for eight weeks as an oral supplement by gavage at a dose level of 100 mg/kg\rBW. When compared with control, E, L/Zi and E + L/Zi decreased muscle triglyceride level by\r30.8%, 28.3% and 57.4%, respectively and increased serum and muscle musclin levels by 58.03%,\r67.4%, 136.5% and 49.4%, 50.1%, 85.6% respectively. In conclusion, it was determined that\rskeletal muscle and systemic musclin levels were stimulated by L/Zi combination in rats subjected\rto chronic exercise
- MakaleAçık Erişim2020The Effect of N-Acetylcysteine on Oxidant/Antioxidant Status in Irradiated Rats
Baykara, Murat; Özçelik, Mehtap; Erisir, Mine; Guler, Osman
N-Acetylcysteine (NAC) is both a strong antioxidant and a glutathione precursor. The effect of NAC on the oxidant/antioxidant status of some tissues of the irradiated rats was investigated. Twenty one rats were assigned to 3 groups; the control group, the irradiation group, for which physiological saline solution was administered as i.p. for three days and then, 9 Gy gamma irradiation was applied, and 3rdirradiation + NAC group for which NAC was adminis-tered as i.p. for three days as 300 mg/kg body weight and then the same dose of irradiation was applied. Upon irradia-tion, the increase determined in malondialdehyde (MDA) was significant in the liver, kidney, and brain tissues of the rats (P˂0.05). While glutathione peroxidase (GSH-Px) activity decreased in all of the tissues and superoxide dismutase (SOD) activity only in the liver (P˂0.01), glutathione (GSH) levels significantly increased in the kidney and ovarium tissues (P˂0.001). While NAC administration returned the increased MDA levels in the kidney and brain as a result of irradiation to normal levels (P˂0.05), it was determined that it did not return the increased MDA levels in the liver tissue to the normal level (P˂0.001). While NAC addition led to a significant increase in GSH levels of the liver, heart, spleen, brain and ovarium tissues compared to both control and irradiation groups, it caused a significant decrease in the kid-ney tissue compared to irradiation group (P˂0.001). As a result of NAC addition, a significant decrease was determined in spleen GSH-Px activity, heart and ovarium SOD activity compared to control and irradiation groups (P˂0.05). It can be asserted that GSH increasing by the addition of NAC is the main antioxidant that has a role in decreasing oxidative stress occurring as a result of irradiation. In the examination of MDA values, it was found that the addition of NAC pro-tected the kidney and brain against the oxidative damage induced by irradiation but NAC addition could remain insuffi-cient for the liver.
AtıfOpenAlex2İncele - MakaleAçık Erişim2020Deneysel Otizm Spektrum Bozukluğu Modeli Oluşturulan Sıçanlarda Likopenin Beyin IL–6, IL–10, FGF–2 ve NGF Düzeyleri Üzerine Etkisi
Sahin, Kazim; Erten, Fusun; Gencoglu, Hasan
Otizm spektrum bozukluğu (OSB), batılı ve gelişmiş toplumlarda artan bir sorundur. Doğası gereği büyük ölçüde genetik olmasına rağmen,birçok çevresel faktör hassas popülasyonlarda OSB'yi tetiklemede rol oynayabilmektedir. Propiyonik asit (PPA) uygulaması, anormal nöralhücre organizasyonunu ve ardından otizm benzeri nörodavranışları içeren kritik değişiklikleri indükleyebilmektedir. Likopen vemetabolitleri beyinde kontrol edilebildiğinden, likopenin merkezi sinir sisteminde nöroprotektif etkileri olabileceği ve başlıca beyin biyobelirteçleri üzerinde modülasyona neden olabileceği düşünülmektedir. Bu çalışmada, 35 adet üç haftalık yaşta Sprague Dawley ırkı erkeksıçan 5 gruba ayrıldı: i) Kontrol. ii) PPA; (500 mg/kg/ip). iii) PPA+LI (PPA’ya ek olarak, 5 mg/kg/gün intragastrik likopen verilen grup), iv)PPA+LII; (PPA’ya ek olarak, 10 mg/kg/gün intragastrik likopen verilen grup), v) PPA+LIII, (PPA’ya ek olarak, 20 mg/kg/gün intragastriklikopen verilen grup). Çalışma sonunda hayvanlar dekapite edildi ve beyin dokuları alınarak homojenize edildi ve SDS-PAGE ve westernblot teknikleriyle beyinde enflamatuar sitokinler interlökin 6 ve 10 (IL6/IL10) ile temel fibroblast büyüme faktörü (FGF-2) ve sinir büyümefaktörü (NGF) düzeylerinin değişimi tespit edildi. Elde edilen sonuçlara göre 35 günlük uygulama sonunda likopenin, PPA ile OSB modelioluşturulan sıçanlarda, PPA’ya bağlı olarak artan IL–6 ve IL-10 düzeylerini özellikle PPA+LIII ve PPA+LII grubunda düşürdüğü tespit edildi.Bununla birlikte, FGF–2 ve NGF düzeyleri de her üç likopen grubunda da belirgin olarak PPA verilen gruba göre artış gösterdi (P<0,0001).Sonuç olarak, likopen, PPA ile indüklenen OSB benzeri nöropatolojik bozuklukları beyin inflamatuar sitokinleri ve büyüme faktörleriniregüle ederek azaltabilir.
- MakaleYalnız künye2017Quercetin'in Koruyucu Etkisinin İncelendiği Ratlarda Alt Ekstremite İskemi-Reperfüzyon Hasarında TAS-TOS Düzeyleri
Akkoyun, Mahire Bayramoğlu; Arihan, Okan; Bengü, Aydın Şükrü; Aydın, Sevinç; Demir, Halit; Birinci, Ceyhun Birinci; Akkoyun, Hurrem Turan; Atçalı, Tuğçe
Objective: It was aimed to determine the protective effectiveness of quercetin in preventing lower extremity ischemia-reperfusion (I/R) injury. Material and Methods: 30 Sprague-Dawley male rats weighing 250-350 g were divided into three groups. Anaesthesia was applied to the first group of rats without ischemia-reperfusion process. To the second group two hours of ischemia and two hours of reperfusion, with the help of left lower extremities tourniquet , were applied. To the third group, 50mg/kg (ip) quercetin application was performed 45 minutes before the ischemia was initiated, two hours of ischemia and two hours of reperfusion application were carried out. At the end of the process, by taking the tissue samples, total antioxidant status (TAS) and total oxidant status (TOS) levels were evaluated. Results:When TAS was evaluated, it was determined that the decrease (p?0.001) occurring in I/R group in comparison with the control group was significant, the decrease (p?0.05) in I/R+Q group in comparison with control group, and again the increase (p?0.001) in I/R+Q group in comparison with I/R group was also significant. When the TOS amounts were evaluated, it was determined that the increase (p?0.001) occurring in I/R group in comparison with control group, the increase in I/R+Q group in comparison with control group (p?0.05), the decrease in I/R+Q group in comparison with I/R group was statistically significant. Conclusion: It has been determined that quercetin has protective effect and decrease the injury occurred in experimental Lower Extremity Ischemia-Reperfusion Injury in Rats.
- MakaleYalnız künye2016Activity of Apoptotic and Antiinilammation on Rainbow Trout (Oncorhynchus mykiss Walbaum, 1792) Infection-Induced Experimentally
Küçükgül, Altuğ; Küçükgül, Azime; Kubulay, Banu
In this study investigated thymol effects on gene expressions relative to pro-inflammatory and apoptosis in tissue fish infected four different trials were formed. All fish were infected with E. coli LPS (25 pg ml'l) expect control and only thymol (THY) supplementation (100 pg ml'1 diet) group fish. The last group was the infected fish fed with thymol supplementation diet (+THY). Kidney and liver tissues were removed day after the experiment period. The gene expression levels of interleukin-1B (IL-1B) and interferon gamma (INF-y) from pro-inflammatory cytokines; caspase (Cas 3) and caspase (Cas 8) from apoptotic cytokines were investigated by Real-Time PCR analyses. Decreases recorded on gene levels of IL—lB and IFNy by LPS treatment, however it was observed that returned to the control level. The comparative results ofLPS and +THY treatment showed that all gene levels significantly stimulated by up regulation. The expression levels of Cas and following LPS caused the increases in liver, no in kidney. However, any change was not observed in only diet application (THY). +THY application showed about 3-fold up-regulations on all gene expressions including apoptosis. It was determined to be effective by showing changes on gene levels including pro-inflammatory and apoptosis. However, further studies are required to better understand immune modulatory effect of diet supplementation feeding on the virulence mechanism offish-infected.