Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Serdar, Osman(3)
- Parlak Ak, Tuba(2)
- Aksu, Önder(1)
- Altınterim, Başar(1)
- Aydin, Rahmi(1)
- Aydın, Ayşe Nur(1)
- Benzer, Fulya(1)
- Dağ, Üzeyir(1)
- Erguven, Gokhan Onder(1)
- Erguven, Gozde(1)
- Erişir, Mine(1)
- Gedik, Osman(1)
- Karaman, Altuğ(1)
- Korkmaz, Volkan(1)
- Pala, Ayşegül(1)
- Tasar, Neslihan(1)
- Yaman, Mine(1)
- Yazdıç, Ferit Can(1)
- Yildirim, Nuran Cikcikoglu(1)
- Özkaya, Ahmet(1)
Yayınlar
- MakaleAçık Erişim2025Determination of Toxic Effect of Gamma Cyhalothrin in Dreissena polymorpha by Some Biomarkers
Parlak Ak, Tuba; Aydın, Ayşe Nur; Serdar, Osman
In this study, the effects of pesticides on the freshwater mussel Dreissena polymorpha, a non-target organism, were aimed to be determined through biochemical responses. For this purpose, first, the acute toxicity value (LC50) of Gamma Cyhalothrin (GCH) pesticide on D. polymorpha was determined by standard static method and the LC50 value was calculated as 13.64 mg/L using probit analysis. Then, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activities, malondialdehyde (MDA) and glutathione (GSH) level responses of D. polymorpha organism exposed to GCH sublethal concentrations for 24 and 96 hours were determined. In addition to biochemical biomarkers, histopathological responses were evaluated. In conclusion, this study demonstrated the abilities of GCH pesticides to induce oxidative stress. Moreover, MDA, GSH levels, SOD, CAT, GPx activities and histopathological responses could be used as an effective biomarker in D. polymorpha.
- MakaleAçık Erişim2024Effect of Synthetic Wastewater on Antioxidant Defence System in Dreissena polymorpha
Serdar, Osman; Erguven, Gokhan Onder; Yildirim, Nuran Cikcikoglu; Korkmaz, Volkan; Erguven, Gozde
The effects of the synthetic wastewater on antioxidant defence system in Dreissena polymorpha was evaluated. For this purpose, SOD, CAT, GPX activities and TBARS and GSH levels in tissues were determined by using commercial kits. The activities of SOD and CAT were in sythtetic group were determined lower than the control group in D. polymorpha during 24 and 96 h (p<0.05). After exposure of the cells of D. polymorpha samples to synthetic wastewater, depletion in GSH levels and subsequent increase in TBARS levels were observed, reflecting their unstable state. According to the data obtained from the study, It can be inferred that the biomarkers being domestic monitored are beneficial and effective in evaluating the biochemical mechanisms of wastewater as early warning indicators.
- MakaleAçık Erişim2023Antimicrobial Activity of Essential Oils of Foeniculum vulgare Mill and Pimpinella anisum L (Apiaceae) Species
Gedik, Osman; Yazdıç, Ferit Can; Tasar, Neslihan; Karaman, Altuğ
Today, essential oils are considered safe substances and can be used as antibacterial additives. Pimpinella anisum L. (Aniseed) and Foeniculum vulgare Mill. var. dulce (fennel) species are of great economic importance. It is among the medicinal and aromatic plants cultivated in wide areas in our country. In this study, it was aimed to determine the antimicrobial properties of essential oils obtained from Foeniculum vulgare Mill. and Pimpinella anisum L plants. The essential oils of the species were obtained by using the distillation method. The antimicrobial activities of essential oils by hand were studied using the hollow agar method. Known to be medically important in food, cosmetics and pharmaceutical products Enterobacter aerogenes (ATCC 13048), Enterococcus faecalis (ATCC 29212), Salmonella enteritidis (ATCC 13075), Staphylococcus aureus subsp. aureus (ATCC 25923), Escherichia coli (ATCC 25922) and Serratia marcescens (ATCC 13880) evaluated against pathogen and microbial contaminants. While Foeniculum vulgare showed results parallel to the antibiotic used as standard, no antibacterial activity was observed in Pimpinella anisum L.
AtıfOpenAlex2TR Dizin2
İncele - MakaleAçık Erişim2020Malathionun Gammarus pulex (Tatlı Su Amphipodu)’te Asetilkolinesteraz Aktivitesi Üzerine Akut Etkisi
Serdar, Osman; Pala, Ayşegül; Aydin, Rahmi
Bu çalışmada, organofosfat insektisit malathionun subletal konsantrasyonlarının Gammarus pulex'in AChE aktivitesi üzerine akut (24 ve 48 saat) etkisi incelenmiştir. Bu amaçla, G. pulex'e malathionun iki farklı sublethal konsantrasyonu (0.1 ve 0.2 mg l-1 ) 24 ve 48 saat boyunca uygulandı. 24 ve 48 saat malathion maruziyetinin sonunda G. pulex örnekleri alındı. Alınan örneklerde AChE enzim aktivitesi ve protein düzeyi belirlenerek, spesifik AChE enzim aktivitesi hesaplandı. Malathionunun sublethal konsantrasyonları G. pulex'te AChE aktivitesininin zamana bağlı artan inhibisyonuna neden oldu. 0.1 mg l-1 malathion konsantrasyonuna maruz kalan grupta, AChE'nin inhibisyonu, kontrol ile karşılaştırıldığında, 24 saatte %50 ve 48 saatte %74 olarak tespit edildi. Benzer şekilde, 0.2 mg l-1 malathion konsantrasyonuna maruz kalan grupta da kontrol ile karşılaştırıldığında sırasıyla 24 ve 48 saatte % 60 ve % 68 AChE inhibisyonu gözlendi. Sonuç olarak, G. pulex'in malathiona 24 ve 48 saat boyunca maruz kalması AChE aktivitesinin yüksek oranda inhibe edilmesine neden olmuştur. Ayrıca, sonuçlar G.pulex'teki % 74'e kadar AChE inhibisyon seviyelerinin akut ölüme neden olmadığını ve G. pulex'teki AChE aktivitesinin ölçümünün akut malathion maruziyetinin ve etkilerinin biyobelirteci olacağını göstermektedir.
AtıfOpenAlex3TR Dizin1İncele - MakaleAçık Erişim2019Influence of Macerated and Cold Press Wheat Germ (Triticum vulgare) Oils Added at Different Rates to Trout Feed on The Feed Rate (FCR), Hematological Parameters and NBT (Nitroblue tetrazolium) Values of Rainbow Trout (Oncorhynchus mykiss)
Aksu, Önder; Altınterim, Başar
In this study, 2% of macerated and cold press wheat germ oils were added to the feeds of rainbow trout (average weight of 39.8 ± 4 g). At the end of the study, growth rate, blood parameters and NBT (Nitro blue tetrazolium) level of rainbow trout were determined. Feed Conversion Ratios (FCR) of groups were determined as macerated: 1.12, cold press: 1.53, control: 1.11. Statistically significant differences were found in red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), white blood cell (WBC), platelet (PLT) values (p<0.05). There was no statistically significant difference between Nitroblue Tetrazolium (NBT) levels (p>0.05).
AtıfTR Dizin1İncele - MakaleAçık Erişim2018Scopus SJRQ4The Effect of Naringenin on Oxidative Stress in Some Tissues (Heart, Lung, Brain, Spleen, Muscle) of Lead-treated Rats
Benzer, Fulya; Dağ, Üzeyir; Erişir, Mine; Özkaya, Ahmet
Naringenin, a flavonoid increases resistance against oxidative stress. The present study aims to investigate the effect of lead on lipid peroxidasyonu and some antioxidants in heart, lung, brain, spleen, muscle and the effect of naringenin on these parameters. Naringenin was administered by orogastric gavage (50 mg/kg, dissolved in corn oil) and lead acetate was given as daily 500 parts per million in drinking water for 4 weeks. In the rats exposed to lead, MDA levels in the brain, lungs, spleen and muscle tissues significantly increased (P<0.001), in the heart tended to increase but not significantly (P>0.05). Lead caused a statistically significant decrease in GSH-Px activity of the brain, spleen and muscle tissues, in CAT activity of the heart, lung and muscle tissues, in GSH concentration of the lungs and muscle tissues (P<0.05). The administration of alone naringenin caused a statistically significant decrease in MDA levels in the heart and muscle, but a significant increase in the lung (P<0.05). Although increased MDA levels in the heart, lungs, brain, muscle and spleen tissues were significantly decreased by use of the naringenin together with lead (P<0.05), increased MDA levels in the lungs and spleen tissues could not be recovered to the normal level. Generally the decreased GSH-Px and CAT activities in these tissues due to lead were significanly increased by naringenin supplementation (P<0.05). In addition, the reduced GSH levels in lung and muscle, the inceased GSH levels in heart with effect of lead were returned to the normal by naringenin. Lead particularly causes to an increase in lipid peroxidation by consuming antioxidants of cells. Naringenin was able to prevent as tissue-specific (brain, muscle) the oxidative stress caused by lead.
AtıfOpenAlex2TR Dizin2İncele - MakaleYalnız künye2016Protective Effect of Ginkgo Biloba Extract 761 on Di-(2-ethylhexyl) Phthalate-Induced Testicular Toxicity in Prepubertal Rats
Parlak Ak, Tuba; Yaman, Mine
Bu çalışmada, ratlara farklı sürelerde aynı dozda di-(2-etilhekzil) fitalat (DEHP) verilerek oluşturulan testiküler hasar üzerine ginkgo biloba ekstrakt 761 (EGb 761)'in koruyucu etkisi incelendi. Yetmiş iki adet 28 günlük Wistar Albino cinsi rat; kontrol, DEHP, DEHP + EGb 761 ve EGb 761 gruplarına ayrıldı. Çalışmanın 7., 14., ve 28. günlerinde hayvanlar dekapite edildi. DEHP uygulamasının kontrol grubu ile karşılaştırıldığında; malondialdehit (MDA), glutatyon peroksidaz (GSH-Px) ve katalaz (CAT) seviyelerinde, testiküler dokuda dejenerasyon, nekroz, atrofi, disorganizasyon, Leydig hücre hiperplazisi ve bazal membran kalınlaşması ile birlikte apoptotik indekslerde belirgin artışlara sebep olmasına karşın, testislerin ağırlıklarında, seminifer tubüllerin çaplarında, germinal hücre tabakası kalınlıklarında, serum testosteron ve glutatyon (GSH) seviyelerinde belirgin azalışlara neden olduğu belirlendi. DEHP uygulanan ratlara EGb 761 verilmesi ile bozulmuş oksidan/antioksidan dengesinde, azalmış testosteron konsantrasyonunda, indüklenmiş testiküler apoptoziste belirgin gelişme ve testiküler dokunun histopatolojik görünümünde kademeli olarak düzelme sağlandığı gözlendi. DEHP' ın uygulanan süre ve dozda testis dokusu için son derece toksik olduğu ve ciddi yapısal hasara sebep olduğu; antioksidan etkiye sahip olan EGb 761'in ise büyük ölçüde bu hasarın önüne geçtiği tespit edildi
AtıfTR Dizin1İncele