Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Bulut, Hasan(53)
- Baskonus, Haci Mehmet(52)
- Alataş, Mevlüt(39)
- Gul, Muhammet(39)
- Serdar, Osman(38)
- Güler, Ömer(37)
- Akkurt, Nevzat(31)
- Benzer, Fulya(30)
- Sulaiman, Tukur Abdulkadir(29)
- Yucesan, Melih(29)
- Zengin, Gokhan(29)
- Kocabaş, Mehmet(28)
- Topal, Murat(26)
- Batan, Nevzat(25)
- Kök, Mediha(25)
- Ezer, Tülay(24)
- Paksoy, Mehmet Yavuz(24)
- Yildirim, Ozal(23)
- Tekin, H.O.(22)
- Utku, Anıl(22)
- ALMisned, Ghada(21)
- Ince, Muharrem(21)
- Öbek, Erdal(21)
- Erten, Fusun(20)
- Aslan, Naim(19)
- Celik, Erkan(19)
- Yildirim, Numan(19)
- Cakilcioglu, Ugur(18)
- Dal, Murat(18)
- Dal, Nursel Alp(18)
- Sahin, Kazim(18)
- Özkaynak, Fatih(18)
- Aslan, Alper(17)
- Erata, Hüseyin(17)
- Orhan, Cemal(17)
- Ergen, Burhan(16)
- Tanyol, Mehtap(16)
- Demir, Yakup(15)
- Etli, Serkan(15)
- Işık, Erdem(15)
Yayınlar
- MakaleAçık Erişim2025Scopus SJRQ1Effects of inspiratory muscle training on physical fitness in cystic fibrosis: a systematic review and meta-analysis
Aksel-Uylar, Aydan Asli; Topcuoglu, Ceyhun; Saglam, Melda; Vardar-Yagli, Naciye
Background: Cystic fibrosis (CF) is a multisystem disease primarily affecting the lungs. It impacts physical fitness due to increased bronchial secretions and exercise intolerance. Inspiratory muscle training (IMT) is recommended as a pulmonary rehabilitation approach. Therefore, we aimed to examine the effect of inspiratory muscle training on health-related physical fitness in CF. Methods: Articles were searched in five databases from inception to June 2025. All randomized controlled trials comparing IMT with a control group in individuals with cystic fibrosis were included. Four randomized controlled trials involving a total of 90 individuals with CF met the inclusion criteria. Results: A significant difference was found in the change in maximal work capacity, maximal minute ventilation, and exercise duration during the exercise test in the IMT group compared to the control group. However, no significant difference was observed in the change in maximal oxygen uptake, 6-minute walk test distance, and oxygen saturation during the 6-minute walk test between the IMT group and the control group. Conclusion: The therapeutic effectiveness of IMT for physical fitness is still uncertain. The evidence is not enough to assess how IMT can be used to enhance health-related physical fitness in CF. Further research should explore the optimal intensity and duration of IMT training needed to improve cardiorespiratory fitness. Additionally, future studies should evaluate how effective IMT is when examining its impact on health-related physical fitness.
- MakaleAçık Erişim2025Scopus SJRQ3Quality Culture and Impact Dynamics in Educational Institutions: A Qualitative Analysis Based on the Experiences of School Administrators
Yaraş, Zübeyde; Gündüzalp, Seda
This study highlights the role of leadership in shaping quality processes within educational institutions, focusing on the development of a quality culture in schools in the K -12 system (from kindergarten to 12th grade). It explores the connection between leadership discourse and organizational transformation. Using a qualitative, phenomenological design, the study involved 22 school principals from preschool to high school, selected through purposive sampling. Data collected through semi -structured forms were analyzed using content analysis. Findings show that school leaders believe quality processes positively influence instructional quality, student development, organizational success, and culture. Leadership communication, shared values, and stakeholder involvement were seen as key to embedding quality in school functions. The study emphasizes the importance of quality culture in areas such as management processes, teaching practices, human resources, and quality control. Strategies like reward systems, promoting innovation, and effective talent management were identified as essential for fostering a quality culture. Challenges faced by administrators in this process were also revealed. To overcome these, suggestions include using positive reinforcement and offering training in quality management. Overall, the study integrates theoretical perspectives on leadership with practical insights into communication and strategy, concluding that a strong quality culture has a significant impact on educational policy.
- MakaleAçık Erişim2025Scopus SJRQ3Sexually transmitted diseases-related knowledge levels of midwifery students studying at two different universities: A comparative study
Yeşiltepe, Akgün; Ulucan, Mihriban; Akan, Ayşenur; Can, Hafize Öztürk
This study aimed to compare the knowledge levels of midwifery students from two universities in eastern and western Turkey regarding sexually transmitted diseases (STDs). A descriptive, comparative study was conducted with midwifery students from both regions.The average score on the STD Knowledge Test was 14.49±3.83. Students from the western university scored 14.63±3.60, while those from the eastern university scored 13.98±4.58. Among western university students, knowledge scores were significantly associated with factors such as year of study, place of residence, and prior sexual health education. For eastern university students, significant factors included age, year of study, social security status, and university-based sexual health education (p<0.05). It is recommended that educational programs be strengthened to enhance students' knowledge and improve access to accurate, reliable information. African Journal of Reproductive Health © 2025.; L'étude visait à comparer les niveaux de connaissance des étudiants sages-femmes de deux universités situées l'est et à l'ouest de la Turquie sur les maladies sexuellement transmissibles. Cette étude descriptive et comparative a été menée auprès d'étudiants des départements de sages-femmes de deux universités différentes situées dans les régions de l'est et de l'ouest de la Turquie. Le score moyen obtenu par le test de connaissances sur les maladies sexuellement transmissibles était de 14,49±3,83. Alors que le score moyen obtenu par « les participants fréquentant l'université de l'ouest de la Turquie était de 14.63±3.60, le score moyen obtenu par » les participants fréquentant l'université de l'est de la Turquie était de 13.98±4.58. Alors qu'il y avait une relation statistiquement significative entre les scores moyens obtenus au test de connaissance des maladies sexuellement transmissibles par les étudiants de l'université de l'ouest et les variables telles que l'année scolaire, le lieu de résidence, l'éducation à la santé sexuelle au lycée, l'éducation à la santé sexuelle à l'université, et la connaissance des maladies sexuellement transmissibles, il y avait une relation statistiquement significative entre les scores moyens obtenus à la même échelle par les étudiants de l'université de l'est et les variables telles que l'âge, l'année scolaire, la sécurité sociale, l'éducation à la santé sexuelle à l'université (p˂0,05). Le niveau de connaissance des étudiants sur les maladies sexuellement transmissibles est insuffisant; il est donc recommandé que les étudiants participent à des activités éducatives pour améliorer leur niveau de connaissance sur les maladies sexuellement transmissibles et pour leur permettre d'accéder à des sources précises et fiables.
- MakaleAçık Erişim2025Scopus SJRQ1Deep learning and optimization-based feature selection for fetal health classification using CTG data
Kaya, Turgay; Kaya, Duygu; Atar, Fatmanur
This study introduces a DL and metaheuristic optimization-based framework for fetal health assessment using cardiotocography (CTG) signals to mitigate maternal and neonatal mortality. One-dimensional CTG signals were transformed into 2D representations, and deep feature extraction was performed using AlexNet. Feature vectors FC6, FC7, and their combination were subjected to optimization via Whale Optimization Algorithm (WOA + DL) and War Strategy Optimization (WSO + DL), utilizing updated fitness functions tailored for feature selection. Experimental results with SVM classifiers demonstrated superior performance with FC6 (89.98 %) and WSO + DL (90.17 %). FC6 exhibited strong discriminative capacity, while FC7 contained semantically richer features. The concatenated FC6 + FC7 vector increased feature diversity. WSO + DL achieved optimal balance across classification accuracy, feature subset size, convergence rate, and overall performance metrics. The integration of DL and metaheuristic algorithms effectively isolated informative feature subsets, improving training efficiency, minimizing redundant/noisy data, reducing overfitting risk, and enhancing classification accuracy. Optimization method selection proved critical to overall model performance.
AtıfScopus6WoS1OpenAlex6
İncele - MakaleAçık Erişim2025Scopus SJRQ1MobileNet- and attention-based MLP-Mixer architecture for geographical-region recognition of a marine fish (Perciformes: Carangidae) using otolith images
Dürrani, Ömerhan; İşgüzar, Seda; İmak, Andaç; Ateşşahin, Tuncay; Cömert, Zafer; Dürrani, Syeda Zahra; Türkoğlu, Muammer
Fishery management is crucial to sustain marine ecosystems by preventing overfishing and ensuring a fair distribution of fishing quotas. Accurately identifying the geographical origins of fish stocks is a key challenge in region-specific management strategies. Otoliths, calcified structures found in the heads of all fish species (except sharks and rays), provide insights into the life history and geographical origins of these fish. Traditional otolith analysis is time-consuming and error-prone because of manual inspection. Our study presents a novel approach using deep learning and computer vision to automate the geographical recognition of fish using otolith images. We propose a model that integrates MobileNet, which is known for its efficiency, with an advanced Mlp-Mixer that incorporates an attention mechanism to extract enhanced features. When tested on a diverse dataset of otolith images from five regions, the proposed model achieved a remarkable 96% accuracy, significantly outperforming traditional methods. This high accuracy demonstrates the potential to revolutionise fishery management by providing a fast, reliable, and automated solution for geographical region identification. In conclusion, the proposed method demonstrates the transformative potential of combining MobileNet and an attention-based Mlp-Mixer for automated fish geographic recognition using otolith images. This innovative method addresses the limitations of traditional manual inspection and paves the way for more effective and sustainable fishery management practices.
AtıfScopus4OpenAlex4İncele - MakaleAçık Erişim2025Scopus SJRQ1An efficient 2D hyper chaos and DNA encoding-based s-box generation method using chaotic evolutionary improvement algorithm for nonlinearity
Garipcan, Ali Murat; Aydin, Yılmaz; Özkaynak, Fatih
In this study, an innovative substitution box (s-box) method is proposed, which combines the complexity and unpredictability of chaotic systems with the natural randomness and security features of Deoxyribonucleic Acid (DNA) encoding, in response to the increasing security requirements in the field of modern cryptography. This method, based on the integration of a two-dimensional (2D) hyper-chaotic Vincent map (VM) and DNA encoding techniques, aims to produce secure and high-performance s-boxes. To evaluate the reliability of the s-boxes, fundamental cryptographic criteria such as nonlinearity (NL), strict avalanche criterion (SAC), differential probability (DP), linear approximation probability (LAP), and bit independence criterion (BIC) are considered. Additionally, a novel chaos-based evolutionary optimization algorithm is proposed to optimize the NL criterion of the s-boxes. This algorithm offers a cost-effective and highly efficient alternative compared to classical metaheuristic methods, providing a balanced structure between security and performance. Experimental findings and comparison results demonstrate that the proposed s-boxes offer effective and reliable solutions for modern cryptographic applications, such as secure data transmission and storage. From a broader perspective, the study makes a meaningful contribution to the literature in the field of data security by presenting a high-performance s-box design meeting the security requirements of cryptographic systems and is resilient against current threats.
AtıfScopus25WoS26OpenAlex23İncele - MakaleAçık Erişim2025Scopus SJRQ1Impacts of methyl jasmonate treatments on quality properties and bioactive compounds of jujube fruit (Ziziphus jujuba) during cold storage
Ozturk, Burhan; Karakaya, Orhan; Aglar, Erdal; Hancı, Mehmet Utku; Ozturk, Ahmet; Asghari, Mohammadreza
Background: Jujube is an important fruit species due to its high nutritional value and health benefits. However, the short shelf life of fruit causes quality losses, making it difficult to trade. This study was conducted to determine the effects of postharvest methyl jasmonate (MeJA) applications on the fruit quality and biochemical properties of ‘Li’ jujube (Ziziphus jujuba Mill.) cultivar. In the study, fruits were pre-cooled at 7 °C and 85 ± 5% humidity for 24 h and those with diseases, pests, and mechanical damage were eliminated. Then, MeJA was applied to the fruits at concentrations of 0.2 mM and 0.4 mM and stored at 0 ± 0.5 °C and 90 ± 5% humidity for 45 days and analyzes were performed at 15-day intervals. Results: This study showed that MeJA applications positively affected the postharvest quality of jujube fruit. MeJA-applied fruits exhibited lower weight loss and lower respiration rates, and MeJA applications helped preserve fruit color and maintained fruit firmness for a longer time. MeJA was effective in maintaining the total phenolic and flavonoid content in fruit content and the loss of vitamin C content was lower with MeJA application. MeJA was effective for determining soluble solids content (SSC), and titratable acidity and delayed ripening in fruit. Conclussion: MeJA application increases the commercial value of fruits by reducing weight loss, slowing down the ripening process, and preserving higher nutritional content and antioxidant activities and suggest that it can be used as a feasible method for improving fruit protection strategies. MeJA application stands out as an effective method for extending the shelf life of jujube fruits by preserving their post-harvest quality and nutritional values.
AtıfScopus7OpenAlex6
İncele - MakaleAçık Erişim2025Scopus SJRQ3Gynaecological cancer awareness and healthy lifestyle behaviors of women aged 20-65 years: A descriptive cross-sectional study
Yaşar, Beril Nisa; Şeker, Sevda Arslan
For both individual and community health, women's health is vital. In particular, gynecological cancers can be prevented or treated by adopting healthy lifestyles, raising awareness, and detecting them early. This study aimed to identify levels of gynecological cancer awareness and healthy lifestyle behaviors among women aged 20-65 years. There were 251 women in the descriptive cross-sectional study. The Gynecological Cancers Awareness Scale (GCAS), the Descriptive Characteristics Form, and the Healthy Lifestyle Behavior Scale-II (HLBS-II) were used to gather data. The data was analyzed using the Pearson's correlation test, multiple linear regression, and descriptive statistics. The average HLBS-II score was 123.53±20.75, while the average GCAS score was 149.64±21.30. The HLBS-II and GCAS scores showed a statistically significant positive correlation. Women knowledgeable about early diagnosis methods scored 10.758 times higher on the GCAS, while women familiar with vulvar self-examination scored 11.016 times higher. Employed women had a mean HLBS-II score 6.124 times higher than non-employed women (p<0.05). Women's awareness of gynecological cancer was high, but they also had moderately good lifestyle choices. To raise awareness and promote healthy lifestyle choices, healthcare professionals are advised to take part in health-promoting initiatives.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2025Scopus SJRQ2Effect of Nano Titanium Dioxide on the Electrical and Thermal Properties of Poly(2,2,2-Trifluoroethyl Methacrylate) for Dielectric Materials
Barım, Esra; Torgut, Gülben
The increasing application areas of energy storage devices in recent years make it necessary to produce materials with sufficient efficiency. In this study, composites of poly(2,2,2-trifluoroethyl methacrylate) P(TFEM) homopolymer with nano titanium dioxide (TiO2 NPs) were prepared for applications of these devices requiring thermoelectric properties, and their thermal, dielectric, and electrical properties were investigated. Thermogravimetric analysis showed that TiO2 NPs in all composites limited the thermal diffusion of TiO2 NPs in the polymer matrix and increased the thermal stability of P(TFEM) from 341°C to 361.5°C. As dielectric properties, the dielectric constant (ε′), dielectric loss (ε″), AC conductivity (σac), and real (Z′) and imaginary (Z″) components of impedance of the composites containing TiO2 NPs were evaluated as functions of frequency and different weight percentages of TiO2 NPs. Increases in ε′ and ε″ at up to 15 wt% TiO2 NPs suggested increased dipole polarization. At 100 Hz, the ε″ value of P(TFEM) increased from 3.2 × 10−2 to 1.1 × 10−2, σac increased from 4.98 × 10−10 to 1.00 × 10−8, Z′ increased from 3.67 × 1010 to 8.66 × 1010, and Z″ increased from 2.09 × 108 to 4.42 × 108. Furthermore, ε′, ε″, and impedance decreased with increasing frequency for both P(TFEM) and TiO2 NPs composites, while σac increased with increasing frequency.
AtıfScopus3OpenAlex5İncele - MakaleAçık Erişim2025Scopus SJRQ2Exploration of UHPLC-ESI-QTOF-MS Profiles and the Neuroprotective, Antidiabetic, Antioxidant and Cytotoxic Effects of Extracts from Achillea maritima (L.) Ehrend. & Y.P.Guo (Asteraceae) Collected in Türkiye
Ahmed, Shakeel; Zengin, Gokhan; Fernández-Ochoa, Álvaro; de la Luz Cádiz-Gurrea, Maria; Leyva-Jiménez, Francisco Javier; Elkiran, Omer; Cakilcioglu, Ugur; Akgul, Bengusu H.; Pereira, Catarina G.; Custódio, Luísa
The current study investigated the chemical composition, antioxidant activity, enzyme inhibition, and cytotoxic activities of extracts from Achillea maritima, a wild medicinal plant used for various therapeutic purposes. The antioxidant activities were assayed through different assays like DPPH, ABTS, CUPRAC, FRAP, and phosphomolybdenum, whereas in enzyme inhibition studies, cholinesterase, tyrosinase, α-amylase, and α-glucosidase were assayed. Cytotoxicity studies are conducted on S17, RAW, and HepG2 to assess its selectivity and effectiveness. Chemical profiling by UHPLC-ESI-QTOF-MS revealed multiple bioactive compounds in the extracts. Polar solvents (ethanol, ethanol/water, and water) resulted in high concentrations of phenolic acids as well as chlorogenic and caffeoylquinic acids, as well as flavonoids like vicenin and apigenin. On the other, the nonpolar (hexane extract) was rich in octadecatrienoic acid hydroperoxy and hydroxyoctadecatrienic acid. Among these, the water extract contained the highest phenolic content of 32.26 mg GAE/g, while the ethyl acetate extract was the richest in flavonoids, with 7.83 mg RE/g. In the antioxidant studies, the water and ethanol/water extracts consistently display the most potent activities, thus indicating their significant free radical scavenging and metal chelation abilities. The studies on enzyme inhibitions showed remarkable BChE inhibitory activities of the ethanol extract in 12.50 mg GALAE/g, thus showing potential in managing disease conditions related to cholinesterase. Tyrosinase inhibition was significant by the ethanol extract, presenting 55.59 mg KAE/g. The ethyl acetate extract exhibited the most potent inhibitory activity against α-amylase with 0.66 mmol ACAE/g, while ethanol extract showed significant inhibition of α-glucosidase with 4.35 ACAE/g. Cytotoxicity results showed that the water extract was most effective against the HepG2 cancer cell line by reducing cell viability to 38.4% at high doses while preserving low toxicity against normal cells, as observed by high viability percentages in S17 and RAW cell lines. These results highlight the usefulness of A. maritima extracts in nutraceutical, pharmaceutical, and cosmeceutical applications.
AtıfScopus15İncele - MakaleAçık Erişim2025First Record of Dreissena caputlacus (Schütt, 1993) and Dreissena polymorpha gallandi (Locard, 1893) in Çamlıgöze Dam Lake (Sivas, Türkiye) and Evaluation of Some Biometric Parameters; [Çamlıgöze Baraj Gölü'nde (Sivas, Türkiye) Dreissena caputlacus (Schütt, 1993) ve Dreissena polymorpha gallandi (Locard, 1893)'nin İlk Kaydı ve Bazı Biyometrik Parametrelerin Değerlendirilmesi]
Kara, Cemil; Kutluyer Kocabaş, Filiz; Kocabaş, Mehmet; Bozali, Nuri; Gürlek, Mustafa Emre
In this study, the presence and biometric characteristics of Dreissena caputlacus (Schütt, 1993) and Dreissena polymorpha gallandi (Locard, 1893) populations were determined in Çamlıgöze Dam Lake. Shell length (SL), shell height (SH), shell width (SW) data of individuals collected in the study area were used with a digital caliper; The weights of individuals (W) were determined using precision scales. The means of SL, SW, SH and W in D. caputlacus and D. polymorpha gallandi were determined as 22.66±4.33 and 30.03±3.17 mm, 15.88±4.16 and 14.54±1.46 mm; 13.37±2.85 and 14.51±1.41 mm; 94±1.12 and 3.29±0.95 g, respectively. According to principal component analysis, there was a strong relationship between SH, SW, SL and W for both species. For D. caputlacus and D. polymorpha gallandi, 82.283% and 94.502% of the total variance was explained by two principal components. D. caputlacus and D. polymorpha gallandi populations from Çamlıgöze Dam Lake were reported for the first time in this study.
AtıfScopus2OpenAlex1
İncele - MakaleAçık Erişim2025Scopus SJRQ3Direct and Inverse Scattering Problems for Sturm-Liouville Operator with Discontinuous Coefficient Under Discontinuity Conditions
Akcay, Ozge; Kosar, Nida Palamut
This paper deals with the study of the direct and inverse problems of scattering theory for Sturm-Liouville operator with piecewise continuous coefficient under the discontinuity conditions at the interior point of the positive semi-axis. The scattering properties are examined and the eigenfunction expansion is obtained. The fundamental equation or Marchenko-type equation of the inverse scattering problem is derived and an algorithm of the reconstruction of the potential according to scattering data of this problem is given. Moreover, the continuity of scattering function of this problem is examined.
- MakaleAçık Erişim2025Scopus SJRQ2Façade lighting designs in historical buildings: The case of Mersin Kızkalesi
Özcan, Gizem Nur; Akar, Tuba
This study discusses the illumination of cultural assets, a live topic worldwide. While any kind of lighting demands expertise, the situation becomes more sensitive in historical building lighting. The necessity of this study is due to the inadequacy of design approaches for historical building lighting, which is becoming increasingly widespread in Türkiye. Lighting examples in the world and in Türkiye are examined and positive-negative aspects identified. The examples are evaluated in terms of various criteria such as illuminance levels, colour, accents, visual order, and architectural suitability, and the necessary criteria for lighting design were established. Based on the theoretical background of the study, a lighting design process has been defined for Kızkalesi. The lighting design proposal was developed not only for touristic and architectural purposes, but also in line with basic principles such as increasing the night visibility of the cultural asset, revealing the values of the structure, and taking into account ecological sensitivities, environmental management, and light pollution. It is thought that this plan, which defines how the process should be handled from beginning to end and which experts and actors should guide the process, can also be helpful in the illumination process of other historical buildings.
- MakaleAçık Erişim2025Scopus SJRQ2Effect of Tungsten Content on the Microstructure, Mechanical and Tribological Properties of AlCoCrFeNi High-Entropy Alloys
Bahceci, Ersin; Gul, Ali Oktay; Basgoz Orhan, Oykum; Kumruoglu, Levent Cenk; Guler, Omer
High-entropy alloys (HEAs) have recently attracted considerable attention due to their unique combination of high strength, hardness, and corrosion and wear resistance, making them promising candidates for advanced structural and functional applications. Among these, AlCoCrFeNi-based HEAs are well known for their high hardness and good wear resistance; however, their limited tribological stability under operational conditions restricts their broader application. To address this limitation, tungsten (W) was incorporated into the AlCoCrFeNi system to enhance its mechanical and tribological performance. In this study, the microstructural, mechanical, and tribological properties of AlCoCrFeNiWx (x = 0, 0.1, 0.25, 0.5 and 1 mol) HEAs were systematically investigated. The alloys were fabricated using the vacuum arc melting method and characterized by XRD, SEM-EDS, elemental mapping, microhardness, and wear tests. The addition of W caused a shift in the 2θ ≈ 44° (110) peak toward lower angles. While the W-free alloy exhibited Body-Centered Cubic (BCC) + B2 phases, W addition led to the formation of a new W-rich phase, and at higher W contents, a pure W phase appeared. The hardness increased from 507.11 HV1 to 651.81 HV1 with increasing W content. Furthermore, wear resistance improved and the coefficient of friction decreased with higher W addition. When comparing the W-free alloy to the alloy with the highest W content, the wear rate decreased by approximately 1.85 times under a 2 N load and 1.89 times under a 5 N load. These results demonstrate that W addition significantly enhances the wear resistance of AlCoCrFeNi-based HEAs by nearly twofold.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ2A novel additive for enhancing biomass energy production from agro-industrial wastes: synthesis of hydrophobic nanoporous silica aerogel and its effect on methane production
Gulsen Akbay, Habibe Elif; Basgoz, Oykum; Guler, Omer
Anaerobic digestion (AD) is one of the most preferred processes for the treatment of organic waste. However, additional processes such as co-digestion, pretreatment, and additive addition continue to be explored to remove the limits on the applicability of AD. This study investigated the effects of hydrophobic nanoporous silica aerogel (NpSA) synthesized from waste rice husks on the anaerobic co-digestion (AnCD) of the mixture consisting of sewage sludge and fruit processing industry wastes. All bioreactors containing NpSA-free, 0.1 g, 0.2 g, 0.5 g, and 1 g NpSA (0.03–0.3 gNpSA/gVSadded) were operated in a mesophilic-batch process. Biogas and methane yields increased from 346 mL/gVS (NpSA-free) to 387 mL/gVS and from 231 mL/gVS (NpSA-free) to 288 mL/gVS, respectively, with 0.1 g NpSA addition. NpSA additive increased biogas production in all bioreactors compared to the blank. However, biogas production rate and methane content increased faster at lower doses of NpSA. Maximum soluble chemical oxygen demand (sCOD), protein, carbohydrate, and volatile solid (VS) reductions were between 45–71%, 35–54%, 44–65%, and 34–91% for NpSA added mixtures, respectively. The hydrophobic NpSA additive was effective in improving the AnCD performance and biogas/methane production. Experimental results fit the kinetic models frequently preferred in such AD processes. In addition, the possible energy and financial potential of the produced methane were also discussed, and it was determined that the direct sale of methane gas produced by the addition of NpSA in the global market could provide 1.4 $/Lmixture more financial gain than the mixture NpSA-free.
AtıfWoS1İncele - MakaleAçık Erişim2025Scopus SJRQ1Exploring the anticancer potential of Dianthus orientalis in pancreatic cancer: A molecular and cellular study
Yildirim, Mehmet Aykut; Sevinc, Burak; Paydas, Samet; Karaselek, Mehmet Ali; Duran, Tugce; Kuccukturk, Serkan; Vatansev, Hakan; Cetiz, Mehmet Veysi; Caprioli, Giovanni; Acquaticci, Laura
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, characterized by limited therapeutic options and poor prognosis. This study investigated the anticancer effects of Dianthus orientalis extracts on pancreatic cancer cell lines (Panc-1 and BxPC-3) with a focus on apoptosis, invasion, and metastasis-related pathways. Chemical analysis using HPLC-MS/MS identified bioactive compounds (vanillic acid, syringic acid, p-coumaric acid, quercetin, hyperoxide) known for their anticancer properties. The Inhibitory Concentration 50 (IC50) value, which is half maximal inhibitory concentration of cancer cells, was determined to be 250 μg/mL at 48 h, and significantly induced apoptosis by decreasing anti-apoptotic gene expressions (Bcl-XL and Bcl-2) and increasing pro-apoptotic gene expressions (Casp3 and Bax) particularly in the Panc-1 cell line. Flow cytometric analysis revealed approximately 55% apoptosis in both cell lines. Molecular docking and dynamics analyses demonstrated strong binding affinities of quercetin and hyperoxide with important cancer-related proteins, including CHEK2 and PALB2. Gene expression analysis demonstrated the upregulation of pro-apoptotic markers like Bax and Casp3, and selective modulation of metastasis-related genes such as SNAI1, PALB2, and CHEK2. The findings highlight the potential of D. orientalis to modulate DNA repair mechanisms and epithelial-mesenchymal transition (EMT) pathways. Furthermore, network pharmacology and in silico tools corroborated its interactions with critical signaling pathways in cancer progression, including PI3K-Akt and MAPK. The study provides the first comprehensive evidence of D. orientalis's antiproliferative through apoptosis induction on pancreatic cancer cell lines, laying the groundwork for future therapeutic applications.
AtıfScopus19İncele - MakaleAçık Erişim2025Scopus SJRQ2Effects of ZrN and DLC coatings on morphostructural, corrosion, cell viability, and antibacterial properties of Ti6Al4V scaffolds
Aslan, Naim; Aksakal, Bünyamin; Cihangir, Salih; Fidan, Ferzan; Yilmazer, Yasemin
Lightweight and functional metallic materials are consistently favored and attract significant attention in the biomedical field. This study investigates the influence of ZrN and DLC coatings on Ti6Al4V scaffolds with varying porosities (40%, 50%, 60%) for biomedical applications. PVD-deposited coatings exhibited distinct growth mechanisms: High-resolution SEM-FIB analyses revealed columnar ZrN structures due to limited adatom mobility, while DLC formed conformal, amorphous layers via high-energy carbon species. Corrosion resistance decreased in 40% porous DLC and 60% porous ZrN-coated samples, likely due to coating defects and increased electrolyte access through open pores. ZrN coatings showed superior antibacterial activity and attributed to surface reactivity and potential ion release. In contrast, the uncoated 60% porous scaffolds demonstrated highest cell viability, suggesting that excessive coating on highly porous structures may hinder cell–material interactions. Furthermore, the cytotoxicity evaluations indicated that uncoated scaffolds exhibited the highest cell viability (77.51%) at 60% porosity after 48 hours, with ZrN coatings demonstrating better efficacy compared to DLC in the 50% and 60% porosity groups.
AtıfScopus3WoS3OpenAlex3İncele - MakaleAçık Erişim2025Scopus SJRQ2PCL/chitosan composite films enhanced with Bi2O3 in nuclear shielding applications: Irradiation resistance, thermal and structural properties
Yılmaz, Demet; Pekdemir, Mustafa Ersin; Dik, Gamze; Selçuk Pekdemir, Sibel; Ulu, Ahmet; Taşgın, Yahya; Ateş, Burhan
In this work, irradiation resistance, thermal, and structural characteristics of Bi2O3-reinforced poly ε-caprolactone/chitosan composites for nuclear shielding applications were studied. PCL/CTS/Bi2O3 composite films were prepared by using different amounts of Bi2O3 (0.5%–4.0% (w/v)). The radiation shielding parameters of the synthesized composite films were both experimentally and theoretically measured at the high energy region. The equivalent dose rates of the prepared film samples were measured using a fast neutron source. Also, to determine the irradiation resistance, the samples were irradiated with Am-241 and Co-60 sources for 30 days. The MFP values at 80.99 keV changed by approximately 61% in samples PCL/CTS and PCL/CTS/4% Bi2O3. The results show that Bi2O3 content increases the gamma shielding abilities in PCL/CTS films. According to TGA results, the thermal stability of the polymer composite films is increased by the addition of Bi2O3 to the PCL/CTS blend film. The results show that PCL/CTS composite materials can be used as protective coating materials for nuclear shielding. Highlights: PCL/CTS/Bi2O3 composite films were prepared by the solvent casting method. The thermal stability of the composite films increased by increasing the Bi2O3 amount. Bi2O3 increased the LAC and MAC values of the composite films. PCL/CTS/Bi2O3 composite films have a neutron shielding effect.
AtıfScopus5WoS5İncele - MakaleAçık Erişim2025Scopus SJRQ2Species classification of microalgae using a CNN-based deep learning approach under optimal cultivation conditions
Simsek, Gokce Kendirlioglu; Ertargin, Merve; Pezzolesi, Laura; Pistocchi, Rossella; Yildirim, Ozal; Cetin, A. Kadri
Microalgae possess significant potential in a wide range of applications due to their valuable bioactive compounds. They are utilized in biofuel production to reduce dependence on fossil fuels, in wastewater treatment for the biological removal of heavy metals and pollutants, in carbon capture for mitigating climate change, and in the pharmaceutical and nutraceutical industries as supplements. As their applications expand, the accurate and efficient identification of microalgal species becomes increasingly important. Traditional classification methods are time-consuming and rely heavily on expert knowledge. The main aim of this study is to develop a reliable, fast, and expert-independent deep learning-based approach for the classification of microalgae species using microscopic images. In this context, deep learning techniques, specifically convolutional neural network (CNN)-based models were employed to classify microalgal species. Four widely used pre-trained CNN architectures (ResNet152, DenseNet201, MobileNetV2, and EfficientNetB0), along with a custom-designed CNN, were implemented. The models were trained and tested on a labeled dataset consisting of microscopic images of Chlorella vulgaris, Scenedesmus acutus, and Haematococcus pluvialis. The classification models achieved accuracy rates ranging from 96.87 % (Custom CNN) to 100 % (DenseNet201), demonstrating the potential of CNN-based approaches in automating and improving microalgae species identification.
AtıfScopus5WoS5OpenAlex5İncele - MakaleAçık Erişim2025Scopus SJRQ3First Recording of Melanopsis costata (Olivier, 1804) in Anamur (Dragon) Stream and Göksu River, Mersin, Türkiye and Measurement of Some Biometric Parameters
Kutluyer Kocabaş, Filiz; Kocabaş, Mehmet
In this study, some biometric characteristics of the freshwater snail Melanopsis costata (Olivier, 1804) were determined in the Anamur (Dragon) Stream and Göksu River (Mersin, Turkey). Weight (A) (g), shell width (KG) (mm), shell height (KY) (mm), aperture length (AU), and width (AG) (mm) measurements were made on the samples taken from different stations. Morphological relationships were determined by multivariate statistical evaluation. The highest values in terms of shell length and weight were evaluated as 24.46 mm and 1.496 g in Karakaya Village (Göksu River). The data were evaluated with Principal Component Analysis (PCA), a flexible statistical method used to understand the relationships between variables and explain a large part of the data set. Samples taken from different stations showed a strong relationship between aperture width and spir height. The species is not mentioned as a new record in the study area.
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