Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Gul, Muhammet(110)
- Güler, Ömer(70)
- Akkurt, Nevzat(69)
- Serdar, Osman(57)
- Yucesan, Melih(55)
- Celik, Erkan(53)
- Tekin, H.O.(52)
- ALMisned, Ghada(49)
- Bulut, Hasan(49)
- Baskonus, Haci Mehmet(48)
- Paksoy, Mehmet Yavuz(46)
- Yildirim, Numan(45)
- Kocabaş, Mehmet(41)
- Yildirim, Nuran Cikcikoglu(41)
- Zengin, Gokhan(40)
- Alataş, Mevlüt(39)
- Ince, Muharrem(38)
- Benzer, Fulya(37)
- Mete, Suleyman(34)
- Aslan, Naim(33)
- Kutlu, Banu(33)
- Yildirim, Ozal(33)
- Topal, Murat(32)
- Tanyol, Mehtap(30)
- Batan, Nevzat(28)
- Özkul, İskender(28)
- Kök, Mediha(27)
- Utku, Anıl(27)
- Can, Erkan(26)
- Danabas, Durali(26)
- Sulaiman, Tukur Abdulkadir(26)
- Ates, Mehmet(25)
- Ezer, Tülay(25)
- Guler, Omer(25)
- Kutluyer, Filiz(25)
- Say, Yakup(25)
- Serin, Faruk(25)
- Erguven, Gokhan Onder(24)
- Onat, Onur(24)
- Cakilcioglu, Ugur(23)
Yayınlar
- MakaleAçık Erişim2026Mapping the Evolution of Interior Architecture and Interior Design: A VOSviewer-Based Bibliometric Analysis
Ay, Ilhami; Dal, Murat; Bekler, Sema; Bekler, Baris
This study conducts a comprehensive bibliometric analysis to explore the academic evolution of interior architecture and interior design literature from 1975 to 2024 using the Web of Science (WoS) database. A total of 3,695 articles were analyzed through VOSviewer software to visualize and interpret research trends, citation networks, co-authorship clusters, and thematic keyword occurrences. The findings indicate a steady growth in publications, particularly after 2006, coinciding with the increasing emphasis on digitalization and sustainability in design. Prominent research themes include biophilic design, adaptive reuse, and the psychological effects of color and space. The dominance of English-language publications is evident, though contributions in Turkish, French, and Spanish are also recognized. Citation analyses identify influential studies that link technical developments with social and psychological perspectives in design. Thematic clustering highlights the interdisciplinary expansion of the field, integrating insights from environmental psychology, ergonomics, and emerging digital technologies such as virtual and augmented reality. This study contributes to the literature by offering a clear roadmap for future research, promoting international collaboration, and strengthening the link between academic inquiry and design practice.
- MakaleYalnız künye2026The Historical-PoliticalJourney of Nominalism from William of Ockham to Foucault
Palanci, Cihan
Nominalism is one of the fundamental ontological-epistemological trajectories that crystallized within Medieval philosophy and played a decisive role in the constitution of modern thought. Rooted in the Ancient Greek debate on universals, this concept attained a systematic structure during the Middle Ages, becoming a horizon that defines the boundaries of modern philosophical practices. Various philosophical and political traditions have problematized established philosophical orthodoxy through the conceptual possibilities offered by nominalism. This study examines the reception of nominalism by different thinkers within the framework of critical theories, specifically focusing on Michel Foucault's historical nominalism. Furthermore, the article analyzes how nominalism, as one of the most potent theoretical foundations of anti-essentialist thought, nourishes the ontological ground of contemporary social movements and how the legacy of William of Ockham is reproduced within an oppositional habitus.
- MakaleAçık Erişim2026The paradox of discourse, representation, and integration in Germany: discursive responses of four german federal parties and turkish politicians within the axis of Kanal Avrupa TV's Bakış Açısı Program (2005-2012)
Senol, Sengul
This study analyzes integration and education policies in the German states of North Rhine-Westphalia and Lower Saxony between 2005 and 2012, within the framework of a multifaceted struggle for hegemony between state actors and politicians of Turkish origin. Using Norman Fairclough's Critical Discourse Analysis (CDA) methodology, the research examines the political discourses in Kanal Avrupa TV's Perspective program, analyzing the positioning of the immigrant subject through textual, discursive, and social practice dimensions. The analysis reveals the discursive differences among the actors representing German state rationality; in this context, a spectrum is observed ranging from the CDU's conservative paternalism to the SPD's economic rationality and the Greens' multicultural participation philosophy. On the other hand, this institutional structure creates a tense space between the German rationality, which confines the immigrant to 'individual integration performance,' and Turkey's protective discourse centered on mother tongue and diasporic identity. The harsh criticisms of Turkish politicians, particularly regarding issues such as obstacles to family reunification and Jugendamt (Youth Welfare Office) practices, demonstrate Turkey's positioning as a new and protective 'transnational actor' towards the diaspora. The study reveals that instead of being caught in this power struggle between Ankara and Berlin, third-generation immigrants are constructing their own independent discourses of 'participation' (Teilhabe) against institutional racism; therefore, what is happening is not an integration crisis, but a demand for equal citizenship.
- MakaleAçık Erişim2026Scopus SJRQ3The relationship between prenatal attachment and death anxiety in high-risk pregnancies
Kasimoglu, Necla; Bas, Nazan G.
This study aims to examine the relationship between prenatal attachment and death anxiety in high-risk pregnancies. The study, a descriptive and correlational design, was conducted with 158 women with high-risk pregnancies in eastern T & uuml;rkiye between May and December 2024. AData were collected using a socio-demographic form, the Prenatal Attachment Inventory, and the Templer Death Anxiety Scale.The mean score on the Prenatal Attachment Inventory (PAI) was 62.1 +/- 10.84, while the mean score on the Templer Death Anxiety Scale was 6.9 +/- 2.99. A positive correlation was found between PAI and Death Anxiety scores (r = .169, p < .005). Death anxiety was predicted by maternal age and the level of prenatal attachment
- MakaleAçık Erişim2026Scopus SJRQ3Investigation of Dielectric Constant and Electrical Conductivity of Poly(MA-co-MMA)/Ce(NO3)3 Composites by Response Surface Methodology for Advanced Dielectric Applications
Torgut, Gulben; Incesu, Rabia
In this study, poly(maleic anhydride-co-methyl methacrylate) [poly(MA-co-MMA)] copolymer and their Ce(NO3)3-filled composites were synthesized and systematically investigated. The copolymer was prepared via free radical polymerization using azobisisobutyronitrile (AIBN) as the initiator in 1,4-dioxane medium. Poly(MA-co-MMA)/Ce(NO3)3 composites were fabricated through a solution mixing technique in accordance with the response surface methodology (RSM) design. Fourier transform infrared spectroscopy (FTIR) results indicated that no significant chemical interaction occurred between the polymer molecule and Ce(NO3)3 particles. Scanning electron microscopy (SEM) images revealed a relatively uniform dispersion of Ce(NO3)3 particles within the polymer, resulting in a rougher surface with increasing filler content and that aggregation occurs at 20 wt%. The presence of Ce(NO3)3 particles in the polymer was confirmed by x-ray diffraction (XRD) analysis. The effects of frequency, applied voltage, and Ce(NO3)3 content on dielectric constant (epsilon) and electrical conductivity (sigma) were optimized using RSM, and the significance of these parameters was evaluated by analysis of variance (ANOVA). An increase in Ce(NO3)3 content significantly enhanced the electrical conductivity, while the applied voltage exhibited no statistically significant effect on dielectric properties. ANOVA results identified Ce(NO3)3 content as the most influential parameter in the developed model.
- MakaleAçık Erişim2026Predicting middle school students' academic achievement in mathematics with aAnew hybrid approach
Dogan, Gurkan; Demiralp, Demet
The academic achievement of middle school students is one of the critical steps in their educational journey that affects their future academic and career prospects. During this transition period, students are faced with a variety of challenges related to their families, schools, and the individual themselves. Research shows that academic performance during these formative years is critical for future educational success and overall life success. Therefore, addressing students' academic achievement, which depends on various factors during this period, is of particular importance for both institutional and individual planning and orientation in the future. In this study, a new hybrid approach based on artificial neural networks that enables automatic analysis of data on family, school, and individual factors affecting middle school students' academic achievement in mathematics is proposed. A publicly available student performance dataset was used for training and testing the proposed hybrid approach and other models. This dataset consists of data such as mathematics grades, family information, residential information, and health status information for 395 students enrolled in two public schools in the Alentejo region of Portugal. The proposed approach achieved an R2 score of 88.6% in experimental studies with this data set, providing approximately 3% higher accuracy than its closest competitor among other methods in the literature.
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İncele - MakaleYalnız künye2026The Voice of European Turks: The Establishment, Broadcasting Practices, and Cultural Role of Germany-Licensed Kanal Avrupa Television
Senol, Sengul
Kanal Avrupa Television is a Germany-licensed Turkish-language media organization that has broadcast continuously since 2004. This study examines its role in supporting cultural memory, identity negotiation, Turkish-language continuity, social participation, and connections with T & uuml;rkiye among Turkish communities in Germany and other parts of Europe. Using a qualitative single-case study and document-analysis approach, the research evaluates the channel's institutional development, broadcasting mission, program content, audience orientation, and digital-platform activities. The findings suggest that Kanal Avrupa Television functions as a diaspora media institution and communicative public sphere in which the identity of the European Turk is articulated and negotiated. Its programs provide opportunities for cultural representation, inter-generational transmission of language and traditions, discussion of social and political concerns, and maintenance of transnational connections. The analysis also identifies economic sustainability, digital transformation, generational change, and editorial independence as important challenges affecting the channel's future. By examining these institutional and cultural dimensions, the study contributes to scholarship on diaspora media, migration, cultural identity, and collective memory.
- MakaleYalnız künye2026Scopus SJRQ2An integrated process for rare earth elements recovery and silica production from Turkish bauxite-related ores
Uysal, Turan; Erüst, Ceren; Erdemoglu, Murat; Sis, Hikmet
The evaluation of bauxite-associated shales as a secondary source of rare earth elements (REEs) is strategically important for securing a sustainable supply of critical raw materials used in advanced technologies. In this study, shale ore associated with bauxite, unsuitable for aluminium production due to its high silica content, was investigated as a potential resource for valuable REEs. The effect of thermal activation on REE recovery was examined, and the potential use of the leach residue as a silica source was assessed. Based on acid leaching results, the optimum calcination temperature was identified as 700 degrees C. Under these conditions, high REE recoveries were achieved: 92.9% La, 89.9% Ce, 89.0% Pr, 88.7% Nd, and 73.0% Sm. After leaching, the residue was enriched in alumina and silica. To improve silica purity and recover remaining REEs and Al, a second-stage leaching process was applied. This resulted in a byproduct containing 55% SiO2 with a specific surface area of 48 m2 g-1, indicating its potential as a silica source. The results demonstrate that bauxite-associated shale can be sustainably valorised through intensive milling, calcination, and acid leaching, enabling efficient REE recovery and the production of a silica-rich byproduct. L'& eacute;valuation de schistes associ & eacute;s & agrave; la bauxite comme source secondaire d'& eacute;l & eacute;ments de terres rares (ETR) est strat & eacute;giquement importante pour garantir un approvisionnement durable en mati & egrave;res premi & egrave;res critiques utilis & eacute;es dans les technologies avanc & eacute;es. Dans cette & eacute;tude, on a examin & eacute; le minerai de schiste associ & eacute; & agrave; la bauxite, inappropri & eacute; & agrave; la production d'aluminium en raison de sa teneur & eacute;lev & eacute;e en silice, comme ressource potentielle d'ETR pr & eacute;cieux. On a examin & eacute; l'influence de l'activation thermique sur la r & eacute;cup & eacute;ration des ETR et l'on a & eacute;valu & eacute; l'utilisation potentielle du r & eacute;sidu de lixiviation comme source de silice. D'apr & egrave;s les r & eacute;sultats de la lixiviation acide, on a identifi & eacute; la temp & eacute;rature optimale de calcination & agrave; 700 degrees C. Dans ces conditions, on a obtenu des r & eacute;cup & eacute;rations d'ETR & eacute;lev & eacute;es: 92.9% de La, 89.9% de Ce, 89.0% de Pr, 88.7% de Nd et 73.0% de Sm. Apr & egrave;s la lixiviation, le r & eacute;sidu & eacute;tait enrichi en alumine et en silice. Afin d'am & eacute;liorer la puret & eacute; de la silice et de r & eacute;cup & eacute;rer les ETR et l'Al restants, on a appliqu & eacute; une deuxi & egrave;me & eacute;tape de lixiviation. Cela a engendr & eacute; un sous-produit contenant 55% de SiO2 et pr & eacute;sentant une surface sp & eacute;cifique de 48 m2/g, indiquant son potentiel en tant que source de silice. Les r & eacute;sultats d & eacute;montrent que le schiste associ & eacute; & agrave; la bauxite peut & ecirc;tre valoris & eacute; de mani & egrave;re durable par broyage intensif, calcination et lixiviation acide, permettant une r & eacute;cup & eacute;ration efficace des ETR et la production d'un sous-produit riche en silice.
- MakaleAçık Erişim2026A Consensus-Edge Initializer for Multi-start 2-opt on the Symmetric Euclidean Travelling Salesman Problem
Saygili, Ahmet Caglar; Kazan, Halim
We study a one-shot consensus-based initializer for multi-start 2-opt on symmetric Euclidean Travelling Salesman Problem (TSP) instances. Given the M local minima from best-of-M 2-opt, we count undirected edge frequencies, greedily assemble a tour from the most frequent edges with a length-biased tie-break, and run a single additional 2-opt descent from this seed. The local search operator is unchanged; the consensus stage reuses existingtours and adds only a small overhead beyond the M descents, and we characterise this overhead analytically while focusing evaluation on tour length improvements. On synthetic Euclidean instances from three generators, we evaluate performance over a grid of problem sizes n and restart budgets M. The consensus + 2-opt pipeline improves best-of-M 2-opt by roughly 3-6% in median tour length with high win rates for n >= 500 and moderate M, while for small n and large M the baseline saturates and gains shrink to zero or slightly negative values. Thus, even a single aggregation step over 2-opt local minima yields a simple, reproducible seed that is beneficial in the practically relevant regime of moderate budgets and larger instances and approximately neutral elsewhere.
- MakaleAçık Erişim2026Scopus SJRQ3Ten-Year Trends in Kidney Transplantation by Donor Type, Age, Dialysis, and Sex/Gender Inequality in Turkiye
Ordin, Yaprak Sarigol; Kankaya, Eda Ayten; Celik, Buket
Introduction: Gender disparity remains a global issue in access to renal replacement therapy and kidney transplantation among patients with end-stage kidney disease. Aim: This study examined trends in donor type, recipient age, and dialysis modality in kidney transplantation in T & uuml;rkiye from 2013 to 2022. A secondary aim was to explore gender disparities in kidney transplantation and treatment modalities for end-stage kidney disease using registry data. Methods: This descriptive and cross-sectional study analyzed the distribution and trends of kidney transplants in T & uuml;rkiye between 2013 and 2022. The data were obtained from the publicly accessible Registry of Nephrology, Dialysis, and Transplantation reports in Turkiye. Per million population increase/decrease rate, chi(2) linear trend, and chi(2) R by C were used. Results: Overtime, transplants from living donors increased, while deceased donor transplants decreased. The highest rates of living donor transplants were in 2022, 2021, and 2019. Transplants in high-risk age groups increased significantly. There were differences in donor type among patients receiving hemodialysis, peritoneal dialysis, or preemptive transplantation (p < .001). Preemptive transplants showed the most significant increase, especially from living donors in 2022. Between 2013 and 2022, kidney transplantation increased by 24.67% in men and 19.94% in women. Female transplant rates were lowest in 2016, 2020, and 2021, indicating a persistent gender gap. There was no significant gender difference in the incidence of hemodialysis or peritoneal dialysis. Conclusion: Living donor transplants, especially preemptive ones, increased markedly over the past decade. Gender disparities persist, and efforts should focus on improving access for women and promoting deceased donor programs to ensure equity.
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İncele - MakaleAçık Erişim2026Piezoelectric energy harvesters in bridge structures: Evaluation of optimal placement and energy harvesting
Sen, Bugra; Polat, Alper; Kapicioglu, Abdullah; Esen, Hikmet
In the present study, energy is harvested from vibrations in bridge structures caused by vehicle passages using piezoelectric energy harvesters (PEHs). In order to maximize the energy harvested, it was aimed to specify the optimal locations of PEHs. In the study, energy harvesting from vibrations in bridge structures was achieved using three different vehicle loads and three different piezoelectric materials. The project of the Ku & scedil;saray & imath;-2 bridge, located in Ku & scedil;saray & imath; village in Baskil, Elaz & imath;& gbreve;, was modelled in the ANSYS program using real measurements. The bridge was analyzed for modal, harmonic, and piezoelectric energy harvesting, respectively. The type with the highest energy production was determined using three different piezoelectric materials (PZT-4, PZT-5A, and PZT-8) for a total of 9 PEHs, and a total of 13 different analyses were performed under three different vehicle loads (60 kN, 90 kN, and 120 kN) to compare the results. The maximum total power obtained from all nine PEHs was 1.484 & micro;W under the 120 kN load with PZT-5A. The maximum power obtained from a single PEH (PEH-1) was 0.49 & micro;W. This power achieved will be adequate for wireless sensor systems used for monitoring the structural health of bridges, and considering that energy harvesting through vibration is independent of meteorological elements, unlike energy sources such as solar and wind, the environmental damage caused by waste batteries in existing systems will be prevented with the dissemination of these systems. With the development of these systems, the energy needs of services such as lighting and traffic signs can be supplied. The results provide an important foundation for the development of vibration-based energy harvesting systems in bridge structures. Thus, the study stands out as an innovative step toward sustainable energy generation in structural engineering.
- MakaleYayıncıda açık erişim2026Scopus SJRQ1Effects of 8-week plyometric training program on balance, reaction time, and attention on elite adolescent female taekwondo athletes
Genç, Harun; Türkmen, Mustafa; Tekin, Irem; Cigerci, Ali Erdem; Gürses, Veli Volkan; Kizar, Oktay; Ökmen, Mehmet Serif; Polatcan, Ismail; Gündogdu, Serhat Dogu
Introduction: Taekwondo is a complex combat sport requiring high levels of strength, balance, reaction time, attention, agility, and endurance for effective performance under rapid offensive and defensive conditions. This study aimed to investigate the effects of an 8-week plyometric training program on static balance (SB), dynamic balance (DB), reaction time (RT), and attention (AT) in adolescent female taekwondo athletes. Methods: Twenty female athletes (age: 14.85 +/- 1.53 years; height: 162.27 +/- 7.12 cm; body mass: 56.69 +/- 6.45 kg) voluntarily participated in the study at Mardin Halit Demir Martial Arts Club. Participants were randomly assigned to either an experimental group (EG, n = 10) or a control group (CG, n = 10). The EG performed plyometric training twice weekly for 8 weeks in addition to regular taekwondo training, while the CG continued only taekwondo training. Static balance was defined as the primary outcome, whereas dynamic balance, reaction time, and attention were considered secondary outcomes. A 2 & times; 2 repeated-measures analysis of variance (group & times; time) was used to examine intervention effects. Results: Significant group & times; time interactions were observed for static balance and dynamic balance (p < 0.05), favoring the experimental group. However, no significant group & times; time interactions were found for reaction time or attention (p > 0.05). Discussion: These findings suggest that plyometric training may effectively improve balance performance in adolescent female taekwondo athletes, particularly static and dynamic balance. However, no significant effects were observed for reaction time or attention. Further studies with larger sample sizes are needed to clarify the potential effects of plyometric training on cognitive performance.
- MakaleYalnız künye2026Examining the Effect of Digital Sports Games on the Motivation Levels of Secondary School Students Regarding Participation in Sports Activities
Bozkurt, Eyup; Toker, Oguzhan; Aldim, Umit Ferit; Akgün, Tarik Fikret; Tümen, Tugba; Erdogan, Ramazan
The aim of this research is to examinethe effect of digital sports games on themotivation levels of secondary school students in participating in sports activities.The research was conducted using a correlational survey model, one of the quantitative research methods, and the researchgroup consisted of 141 volunteer students(80 male, 61 female) studying at the secondary school level in different provincesduring the 2024-2025 academic year. Apersonal information form and the DigitalSports Games Motivation Scale, developedby Kim and Ross (2006) and expanded byCianfrone et al. (2011), were used as datacollection tools. The SPSS software package was used for data analysis, and significance was accepted as p < 0.05. According to the research findings, it was determined that the students' motivation levels for digital sports games were generallyat a moderate level. The sub-dimensionswith the highest motivation were identified as team commitment, entertainment,and socialization. No statistically significant difference was found in digital sportsgame motivation levels according to gender, height, body weight, place of residence, income level, and parental educa-tion level variables (p > 0.05). Regarding the weekly digital game playing timevariable, a significant difference was foundonly in the entertainment sub-dimension;students who played digital sports gamesfor 5-8 hours a week had higher entertainment levels than the other groups (p <0.05). In conclusion, it can be said thatdigital sports games play a motivating rolefor secondary school students, especially inthe dimensions of entertainment and teamcommitment, but this effect is related togame time and the quality of interactionwith the game rather than demographicvariables. It is suggested that digital sportsgames should be considered not as an alter-native to physical sports activities, but as asupportive and complementary element tointerest in sports.
- MakaleAçık Erişim2026Scopus SJRQ1Ellagic Acid Mitigates Lead (Pb)-Induced Toxicity in Cyprinus carpio: A Multi-Biomarker Assessment of Hematological, Immunological, and Oxidative Stress Responses Supported by Molecular Docking
Eroglu, Mucahit; Cakmak, Mehmet Nuri; Pala, Aysegul; Uslu, Harun; Yonar, Serpil Mise; Ispir, Unal; Orhan, Cemal; Yonar, Muhammet Enis
Lead (Pb) is a widespread environmental pollutant that induces systemic toxicity in aquatic organisms primarily through oxidative stress, hematological disruption, and immune dysfunction. This study investigated the protective effects of ellagic acid (EA) against Pb-induced toxicity in common carp (Cyprinus carpio) using a multi-biomarker approach and molecular docking. Fish were assigned to six experimental groups: control, EA-treated, Pb-I, Pb-I + EA, Pb-II, and Pb-II + EA. Fish in the Pb-I and Pb-II groups were exposed to 2.5 and 5 mg/L Pb, respectively, while EA was administered via diet at 100 mg/kg for 14 days. At the end of the exposure period, hematological indices, innate immune parameters, and oxidative stress biomarkers were assessed in blood, liver, kidney, and gill tissues. Pb exposure caused marked hematological impairment, suppressed immune responses, increased malondialdehyde levels, and disrupted antioxidant defense by reducing SOD, CAT, GSH-Px, and GSH levels while increasing GST activity. In contrast, dietary EA supplementation significantly mitigated Pb-induced alterations, improved hematological and immunological responses, reduced lipid peroxidation, restored antioxidant capacity, and normalized GST activity to control levels. Molecular docking analyses further showed that EA interacts with hemoglobin and immunoglobulin M, supporting its potential role in preserving oxygen transport and immune functions under Pb-induced stress. Overall, the findings demonstrate that Pb-induced toxicity involves coordinated disruption of redox homeostasis and immune function, whereas EA exerts a multi-target protective effect through biochemical and molecular mechanisms. This study provides mechanistic insight into chemical-biological interactions and supports the potential application of natural bioactive compounds in mitigating heavy metal-induced toxicity.
- MakaleAçık Erişim2026Scopus SJRQ2A New Metacognitive Confidence Calculation Approach Based on Large Language Models for Natural Language Explanations
Yilmazer Gundem, Merve; Sahin, Simay; Karakose, Mehmet
Traditional methods used to measure metacognitive confidence rely on superficial features such as word count and ambiguity and therefore fail to adequately reflect the level of metacognitive confidence in statements. In this study, in addition to traditional text-based confidence measures, we used a Large Language Model (LLM) to directly analyze confidence and its ratio in statements. LLM-based confidence scores were calculated on statements from the e-SNLI and CoS-E open-source datasets, and the prediction performance obtained with traditional features was compared. The results indicate that traditional surface-level text features explain the variance in LLM-generated confidence scores to a limited extent, and that LLM-based scores are significantly correlated with independent researcher evaluations. This study contributes to the literature by offering a scalable and reproducible analytical framework for measuring metacognitive confidence. It is believed that the findings can be directly applied, particularly in applications where trust is critical, such as automated software test scenario generation, decision support systems, and risk management. The use of LLMs offers a framework for the LLM-based analysis of potential metacognitive confidence signals in natural language explanations by examining the sense of confidence and certainty with which statements are presented, rather than their factual accuracy.
- MakaleAçık Erişim2026Scopus SJRQ1A multi-evidence computational and experimental strategy for Silene nerimaniae: combining phytochemical characterization, bioactivity assessment, and ADEFRank-HCT-116-based metabolite prioritization
Erharman, Ahmet; Yagi, Sakina; Uba, Abdullahi Ibrahim; Nikolić, Filip; Gašić, Uroš; Acar, Mikail; Dogan, Nurettin; Koyuncu, Ismail; Yapıcı, Ismail; Gulcin, Ilhami
This study presents the first comprehensive evaluation of the phytochemical composition, antioxidant properties, enzyme inhibitory effects, and cytotoxic potential of Silene nerimaniae G.E.Genç, Kandemir & İ.Genç (family Caryophyllaceae). Ethyl acetate, acetone, 70% acetone, and aqueous extracts were obtained from the aerial parts of the plant through maceration. Among the tested extracts, the acetone extract contained the highest total phenolic (24.37 mg GAE per g) and flavonoid (24.64 mg RE per g) contents. LC–MS analysis identified 52 bioactive constituents, including sugars, organic acids, phenolic acids, flavonoids, and fatty acids. The aqueous extract demonstrated the strongest radical scavenging activity against DPPH (23.02 mg TE per g) and ABTS (55.76 mg TE per g), as well as the highest Fe3+ reducing power (37.53 mg TE per g). In combination with the acetone extract, it also exhibited notable Cu2+ reducing activity (47.78 mg TE per g). Regarding enzyme inhibition, the ethyl acetate, acetone, and hydroacetone extracts displayed the strongest inhibitory activities against acetylcholinesterase (1.87 mg GALA per g), butyrylcholinesterase (2.92 mg GALA per g), and tyrosinase (60.44 mg KAE per g), respectively. All three extracts also inhibited α-amylase activity within the range of 0.73–0.77 mmol ACAE per g (p ≥ 0.05). In addition, the hydroacetone extract showed considerable inhibition of human carbonic anhydrase isoenzymes I (IC50 = 38.78 μg mL−1) and II (IC50 = 19.59 μg mL−1). The ethyl acetate extract exhibited the strongest cytotoxic effect against the colorectal cancer cell line HCT-116, with an IC50 value of 0.639 μg mL−1 and a selectivity index of 1.7. To contextualize this HCT-116-associated activity at the metabolite level, an ADEFRank-HCT116 (abundance–domain–evidence fusion ranking) workflow was applied by integrating EtOAc abundance, HCT-116-oriented QSAR evidence, applicability-domain confidence, and structure-assignment reliability. This analysis prioritized diosmetin, luteolin, eriodyctiol, acacetin, and isorhamnetin as core candidates for structure-based follow-up. Molecular docking screening predicted favorable docking profiles for the prioritized candidates, while 100 ns molecular dynamics simulations were used to assess the dynamic stability of the representative luteolin–PI3Kα, diosmetin–AKT1, and isorhamnetin–GSK-3β complexes. Taken together, these results indicate that S. nerimaniae may represent a valuable source of active compounds for various functional nutraceutical, cosmetic and pharmaceutical uses. This journal is
- MakaleAçık Erişim2026Scopus SJRQ1Integrating experimental and atomistic insights into the rejuvenation of aged binder using bio-based rejuvenators
Kurban, Mustafa; Yalcin, Beyza Furtana; Yilmaz, Mehmet; Akpinar, Sinan; Kök, Baha Vural; Hekim, Seda; Özdemir, Ahmet Münir; Yalcin, Erkut; Göktaş, Fahrettin
This study integrates experimental and computational methods to evaluate the rejuvenation performance of an aged asphalt binder using two novel bio-based additives, 1T and 2T. The aged binder, sourced from reclaimed asphalt pavement (RAP), was modified with 25 wt% of each rejuvenator (denoted as 1T25 and 2T25, respectively). SARA (Saturates, Aromatics, Resins, Asphaltenes) fractionation and colloidal indices were used to assess compositional recovery. Both additives increased aromatic and resin contents while reducing asphaltenes. The 2T-modified binder achieved the highest colloidal stability (Ic = 0.29) and the most pronounced improvement in stability indicators (CI and Ic) among the tested systems. Complementary molecular dynamics (MD) simulations using the COMPASSII force field modeled the structural and thermodynamic behavior of RAP and rejuvenated systems. The 2T25 system exhibited higher density and more compact molecular packing, suggesting stronger cohesive organization and reduced free volume, whereas 1T25 showed greater molecular spacing and flexibility. RDF analysis and converged thermodynamic/structural trajectories (energy, temperature, cell length, and density stabilization) further supported rejuvenator-dependent rearrangement of packing during equilibration. Overall, MD acts as a mechanistic bridge that interprets experimental SARA/CI/Ic trends and supports design-oriented development of sustainable rejuvenators.
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İncele - MakaleAçık Erişim2026Scopus SJRQ3Determination of Oxidative Stress Responses Induced by the Combination of 4 Different Rare Earth Elements in Dreissena polymorpha; [Determinacija odgovorov na oksidativni stres, ki ga povzroča kombinacija 4 različnih redkih zemljinskih elementov v Dreissena polymorpha]
Serdar, Osman; Aydin, Ayşe Nur
Rare Earth Elements (REE), whose usage areas are increasing day by day, are increasing in the amount of mixing with the environment, causing changes in antioxidant enzyme activities by causing oxidative stress in living organisms. In this study, it was aimed to examine the oxidative stress responses induced by the mixture of 4 different REEs (terbium, gadolinium, Lanthanum, Praseodymium) in Dreissena polymorpha. For this purpose, sublethal concentration values were determined by literature review. Experimental application was carried out within 24 and 96 hours. In the analyzes performed to determine biomarker responses, samples taken from living organisms were weighed and homogenization processes were performed for the analysis of samples taken from the experimental groups, including the control group. After homogenization, samples were centrifuged at 4.000 rpm for 15 minutes. Supernatants were kept at -86 °C until measurements were made. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities, and glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) levels were determined using ELISA kits. Statistical analyses were performed using SPSS. One-way ANOVA (Duncan’s multiple range test; p < 0.05) was used for comparison of measured parameters among groups. As a result of the application, a decrease in CAT activity and GSH level and an increase in TBARS levels were observed after 96 hours compared to the control group, while no statistically significant difference was detected in SOD and GPx activities.
- MakaleYalnız künye2026Scopus SJRQ2An Investigation of the Variability of Short-Term Drought with SPEI-Based Severity, Duration and Magnitude Parameters in a Transboundary Basin
Akbas, Ergun; Acar, Ramazan; Eşit, Musa; Koycegiz, Cihangir
Climate change-induced variability in the water budget leads to significant drought events. In this study, severity, duration, and magnitude parameters obtained from 1-month and 3-month series of the Standardized Precipitation Evapotranspiration Index (SPEI) were used to investigate short-term drought from different perspectives. The lower part of the Euphrates-Tigris Basin, which is a transboundary basin, was preferred as the study area within the borders of Türkiye. In this study, monthly total precipitation and monthly mean temperature data for the period 1963–2021 were used. Both graphical (Şen Innovative Trend Analysis) and statistical (Mann–Kendall, Spearman’s Rho, Sen’s Slope Estimator) trend analysis methods were applied to detect, categorize, and analyze the variability of drought. The Combination of Wilcoxon Test and Scatter Diagram (CWTSD) method, which offers both graphical and statistical trend analysis capabilities, was preferred to enhance consistency and facilitate comparison of results. According to the findings, more severe droughts are observed in the eastern part of the basin compared to the western part. Across the basin, severity and magnitude are decreasing, while duration is increasing. The increase in duration indicates that droughts are shifting from short-term to long-term periods. This situation is of great importance in terms of planning agricultural strategies.
AtıfOpenAlex3İncele - MakaleYalnız künye2026Scopus SJRQ1Compositionally segmented thermoelectric BiSbTe thin films on Cr/Si(100)
Yüzüak, G. Durak; Yüzüak, E.
Compositionally segmented thermoelectric (CS-TE) structures improve thermal energy conversion efficiency across large thermal gradients. However, their increased design complexity complicates performance modeling and optimization. In this study, we fabricate CS-TE BiSbTe thin films on Cr-buffered Si(100) substrates. By adopting a multidisciplinary approach, we aim to broaden the technological applicability and strategic relevance of advanced TE systems. We systematically analyze the influence of deposition pressures (5, 7, and 10 mTorr) on TE performance. Variations in working pressure alter the Bi/Sb atomic ratio in the films, while the Te content remains stable. This enables the controlled formation of CS structures. At 323 K, the power factor (PF) of TE thin films reaches 0.7, 2.4, and 7.3 mW/mK2 under 5, 7, and 10 mTorr deposition conditions, respectively. The Cr-buffered layer significantly improves the electrical conductivity of CS-TE BiSbTe films. We further engineer a p-type single-leg device integrating nanostructured Bi0.35Sb1.65Te3, Bi0.37Sb1.63Te3, and Bi0.4Sb1.60Te3 layers. These materials are optimized to achieve peak TE PF values across a wide temperature range (320 to 500 K) while ensuring robust interfacial adhesion. The CS-TE device generates 3 mW/cm2, showing a 15% improvement over single-composition samples at a 100 K temperature difference.
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