Munzur ÜniversitesiMunzur ÜniversitesiAçık Erişim Arşivi · RDL Open

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  • MakaleAçık Erişim2024Scopus SJRQ1
    Exploring Chemical Composition, Antioxidant, Enzyme Inhibitory and Cytotoxic Properties of Glaucium acutidentatum Hausskn. & Bornm. from Turkey Flora: A Novel Source of Bioactive Agents to Design Functional Applications

    Yagi, Sakina; Zengin, Gokhan; Uba, Abdullahi Ibrahim; Maciejewska-Turska, Magdalena; Sieniawska, Elwira; Świątek, Łukasz; Rajtar, Barbara; Bahşi, Muammer; Guler, Osman; Dall’Acqua, Stefano

    The present study was performed to determine the chemical constituents, cytotoxicity, antioxidant and enzyme inhibition activities of the aerial parts of Glaucium acutidentatum Hausskn. and Bornm. (family Papaveraceae). Methanolic and aqueous extracts were prepared by maceration, homogenizer-assisted extraction (HAE) and infusion. Results showed that the highest total phenolic and flavonoids contents were obtained from the methanol extracts obtained by HAE (53.22 ± 0.10 mg GAE/g) and maceration (30.28 ± 0.51 mg RE/g), respectively. The aporphine, beznyltetrahydroisoquinoline, and protopine types of Glaucium alkaloids have been tentatively identified. Among them, glaucine was identified in all extracts. Flavonoids, phenolic acids, coumarins, organic acids and fatty acids were also detected. Methanolic extract obtained using the HAE method displayed the highest anti-DPPH (41.42 ± 0.62 mg TE/g), total antioxidant (1.20 ± 0.17 mmol TE/g), Cu2+ (113.55 ± 6.44 mg TE/g), and Fe3+ (74.52 ± 4.74 mg TE/g) reducing properties. The aqueous extracts obtained by infusion and HAE methods exerted the best anti-ABTS (103.59 ± 1.49 mg TE/g) and chelating (19.81 ± 0.05 mg EDTAE/g) activities, respectively. Methanolic extract from HAE recorded the highest acetylcholinesterase (2.55 ± 0.10 mg GALAE/g) and α-amylase (0.51 ± 0.02 mmol ACAE/g) inhibition activities, while that obtained by maceration showed the best butyrylcholinesterase (3.76 ± 0.31 mg GALAE/g) inhibition activity. Both extracts revealed the best tyrosinase inhibitory activity (25.15 ± 1.00 and 26.79 ± 2.36 mg KAE/g, p ≥ 0.05). G. acutidentatum maceration-derived aqueous extract showed selective anticancer activity against cells originating from human hypopharyngeal carcinoma. In conclusion, these findings indicated that G. acutidentatum is a promising source of alkaloids and phenolic compounds for variable pharmaceutical formulations.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus13OpenAlex13
    ScopusWeb of SciencePubMedİncele
  • MakaleYalnız künye2024Scopus SJRQ1
    Virtual reality for COPD exacerbation: A randomized controlled trial

    Kizmaz, Erhan; Telli Atalay, Orçin; Çetin, Nazlı; Uğurlu, Erhan

    Background: Pulmonary rehabilitation (PR) is an effective treatment method for chronic obstructive pulmonary disease (COPD). However, individuals with chronic diseases that require lifelong treatment and experience exacerbations need motivational methods. Objectives: The aim of this study was to examine the effects of virtual reality on symptoms, daily living activity, functional capacity, anxiety and depression levels in COPD exacerbation. Methods: Fifty patients hospitalized for COPD exacerbation were included in the study. They were randomly assigned to two groups. Twenty-five patients participated in a traditional PR (once-daily until discharge), including pedaling exercises. The second/25 patients followed the same protocol but experienced cycling simulation in the forest via virtual reality (VR + PR). All patients were evaluated using 1-minute/Sit-to-Stand test (STST), modified-Medical Research Council (mMRC) scale, COPD Assessment test (CAT), Hospital Anxiety and Depression Scale (HADS), and London Chest Activities of Daily Living (LCADL) before and after the treatment. Results: The STST showed an increase in both groups post-treatment, notably higher in the VR + PR (p = 0.037). Dyspnea levels and CAT scores decreased in all patients, but the decrease was greater in the PR + VR group for both parameters (p = 0.062, p = 0.003; respectively). Both groups experienced a reduction in the HADS scores compared to the pre-treatment, with a more significant decrease in depression and the total score in the VR + PR (p < 0.05). LCADL's sub-parameters and total score, excluding household, decreased in both groups after treatment (p < 0.05). The improvement was more substantial in the VR + PR. Conclusions: Virtual reality provides benefits in the management of COPD exacerbations and can be used safely. Clinical trial registiration: Registered at clinicaltrials.gov, registration ID: NCT05687396, URL: www.clinicaltrials.gov.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus11WoS11OpenAlex15
    ScopusWeb of SciencePubMedİncele
  • MakaleYalnız künye2024Scopus SJRQ4
    How How Much Much CCondensation ondensation Occurs Occurs With With Various Various Insulation Insulation Thicknesses? Thicknesses?

    Kahraman, Gökhan; Isik, Erdem

    Scopusİncele
  • MakaleAçık Erişim2024Scopus SJRQ2
    Smart alloy metalized novel photonic NEMS photodiode with CuAlV/n-Si/Al junction structure

    Karaduman, Oktay; Canbay, Canan Aksu; Dere, Aysegul; Orman, Yusuf; Al-Ghamdi, Ahmed A; Al-Sehemi, Abdullah G; Yakuphanoglu, Fahrettin

    In this work, a novel smart (shape memory) alloy metalized photonic silicon wafer photodiode with Schottky type CuAlV/n-Si/Al contact structure as a nano-electro-mechanical-system (NEMS) photodevice was fabricated by thermal evaporation technique. The CuAlV memory alloy used as the top Schottky metal contact electrode was produced by arc melting technique and a subsequent quenching in an iced-brine water medium, and its shape memory effect characteristics were revealed by thermal and structural tests. The fabricated photonic NEMS photodiode was characterized by different photo-electrical (I-V, I-t) and frequency/time dependent and illuminated capacitance (C-V/f, C-t, C-V/ill.) and conductance-voltage (G-V) measurements under different frequencies and artificial light intensity power conditions. The I-V tests showed an excellent current rectifying ability and very well net photocurrent generation features of the photodiode. The specific detectivity of the photodiode was found as high as almost approaching 1011 Jones. The SCLC (space charge limited current conduction) analyses made on the double-log I-V plots of the photodiode revealed that the trap-filling TFL-SCLC and trap-free SCLC current conduction mechanisms are the two prevailing conduction mechanisms in the forward bias voltage region. The density of interface states (Dit) of the fabricated photodiode was determined. Moreover, an excellent reproducibility of light-induced photocapacitance formation of the novel photodiode was demonstrated by C-V/t measurements under different artificial light power intensities.

    AtıfScopus5OpenAlex5
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  • MakaleAçık Erişim2024Scopus SJRQ1
    A new algorithm to generate aes-like substitution boxes based on sine cosine optimization algorithm

    Artuğer, Fırat; Özkaynak, Fatih

    Symmetric encryption approaches are generally used for data encryption. One of the basic requirements for symmetric encryption algorithms to provide security is strong s-box structures. Because s-box is a nonlinear unit in these encryption algorithms and provides the requirement called confusion. In this article, a new technique is developed to produce effective s-boxes like the 16*16 s-box structure used in the AES algorithm. In the proposed method, the sine cosine algorithm (SCA), one of the recently developed optimization algorithms, is used. SCA is a suitable option for generating strong s-boxes because of its strong randomness and ease of implementation. The proposed method first uses a logistic map to generate the initial population. Then, the nonlinearity value is optimized with the help of the sine cosine algorithm. The proposed method reaches the highest nonlinearity value (112) by relocating 126 values in the s-box structure produced initially. Looking at the results, it is seen that the proposed method gives better results than other optimization-based s-box creation methods. This new method has significant potential to improve the security of symmetric encryption algorithms and make data encryption processes stronger.

    AtıfScopus19WoS22OpenAlex24
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  • MakaleAçık Erişim2024Scopus SJRQ1
    Production of Ho2O3 and Dy2O3 rare earth oxides doped selenium thin film and investigation of surface morphology and optical properties

    Aydin, Handan; Sait Kanca, M.; Kök, Mediha; Taşgin, Yahya; Tatar, Beyhan

    Thin film technology aims to improve and develop the properties of materials by coating technology. In this study, thin films consisting of rare earth element and selenium semiconductor material, which have recently been preferred in technological applications due to their important properties, are examined. Selenium thin films doped with Ho2O3 and Dy2O3 rare earth oxides (REO) were fabricated on glass substrate by thermal evaporation method. The surface morphology and optical properties of the thin films were investigated. As a result of surface morphology examinations, it was determined that homogeneous thin films were obtained and the thickness of the thin films varied between 20 and 30 μm. In addition, the roughness value of the glass substrate decreased as a result of coating with doped selenium thin film. The band energy value obtained by UV-VIS measurements decreased compared to glass and was close to the selenium element value. In the comparison between selenium coatings doped with Ho2O3 and Dy2O3, a notable reduction in the Eg value was observed specifically in the Ho2O3 doped coatings.

    AtıfScopus3OpenAlex3
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  • MakaleYalnız künye2024Scopus SJRQ2
    Introducing the chemical potential of Cu–Mn–Al alloys for structural, electrical and thermal properties

    Yüzüak, E.; Durak Yüzüak, G.

    This study investigates the Martensite transition in Cu–Mn–Al alloys (CMAs) via the use of many methods, including scanning electron microscopy, temperature-dependent X-ray diffraction, resistivity and thermal measurements. The Martensite transition hysteresis and characteristic temperature are primarily determined by the alloy composition, crystal structure and residual stress. Furthermore, these alloys have been reported to have surface and crystallographic characteristics often associated with twinning structures. Resistivity experiments conducted during heating and cooling cycles demonstrate a 2.57-fold increase inside the phase change zone, emphasizing the influence of the transition on electrical conductivity. The Martensite transition temperature may be altered by 110 K by the manipulation of the electron-to-atom ratio (e/a), indicating the high susceptibility of this temperature to changes in chemical composition. Differential scanning calorimetry shows that the transition is accompanied by a maximum entropy shift of 48 J kg−1. K, which offers valuable information on the thermodynamic driving factors involved. This work successfully attains a cooling power of 1350 W, which is equivalent to the cooling power of NiTi wire (1500 W), by using a theoretical manufacturing method and optimizing the CMAs. Overall, this work clarifies the Martensite transition in CMAs, highlighting its impact on their characteristics and indicating their potential for effective thermal energy storage and release applications. It is advisable to further optimize their performance and economic viability by considering the e/a ratio.

    AtıfScopus3WoS3OpenAlex4
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  • MakaleYalnız künye2024Scopus SJRQ1
    Influence of praseodymium oxide on the structural, mechanical and photon, charged particles, and neutron shielding properties of alumina borate glass

    Acikgoz, Abuzer; Izguden, Ilyas; Tasgin, Yahya; Yilmaz, Demet; Demircan, Gokhan; Kalecik, Sedanur; Aktas, Bulent

    The structural, mechanical and radiation shielding properties of (69-x)B2O3-20TeO2-10Al2O3-1HfO2-xPr6O11 (where x = 0, 0.25, 0.5, 0.75, 1 mol %) glass system were investigated. This study introduces a novel approach by incorporating Pr6O11 into glass composition, highlighting its unique contributions to enhancing elastic properties, fracture toughness, hardness, and radiation shielding abilities. Experimental measurements were conducted within the energy range of 59.54–661.62 keV and theoretical calculations are made for MAC values. The presence of Pr6O11 was noted to positively influence the gamma shielding capabilities. At 59.54 keV, the addition of 0.25 mol% Pr6O11 increased the mass attenuation coefficient of the glass by 2.9 %, and the addition of 1 mol% Pr6O11 increased it by 29.8 %. The addition of 0.25 mol% Pr6O11 increased the fast neutron removal cross section of the glass by 4.4 %. Also, it is observed that the glass with 1 mol% Pr6O11 is the best shielding material against alpha and proton particles. A significant enhancement of 24.36 % in the fracture toughness value was observed, increasing from 1.059 to 1.317 MPa m1/2 at 1 mol% Pr6O11. Experimental hardness values increased from 3.374 to 3.985 GPa, resulting in an improvement of 18.11 % at 1 mol% Pr6O11. The thermal stability (ΔT, °C) value demonstrated a notable increase from 85 to 106, indicating a significant 24.7 % improvement at 0.25 mol% Pr6O11.

    AtıfScopus58WoS57OpenAlex60
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  • MakaleAçık Erişim2024Scopus SJRQ1
    A broad-spectrum biological activities of Heracleum humile extracts: A first report of the antiviral, anti-cancer and chemical properties

    Ocal, Mustafa; Duran Yelken, Selda; Altunoglu, Yasemin Celik; Baloglu, Mehmet Cengiz; Soomro, Sanam Iram; Zengin, Gokhan; Angeloni, Simone; Mustafa, Ahmed M.; Caprioli, Giovanni; Paksoy, Mehmet Yavuz

    The current work focused on researching the bioactive potential of ethyl acetate (EA), methanol (MeOH), and water extract of H. humile plant, specifically ethyl acetate, methanol extracts were acquired with maceration method, and water extract was obtained by the infusion method. The highest total phenolic ingredient was determined in the water extract, while the highest total flavonoid ingredient was found in the MeOH extract. The water extract displayed the most potent antioxidant activity in the assays used. The ethyl acetate extract showed the highest enzyme inhibition activity in Butyrylcholinesterase inhibition (BChE) and amylase assay. Antibacterial efficiency was analyzed using microdilution analysis. The minimum inhibitory concentration (MIC) amounts ranged from 125 to 500 μg/mL except for water extract. The antiviral potential of the extracts was assessed against Bovine herpes virus 1 (BoHV-1) (Cooper strain). Methanol extract showed more potent antiviral effect. Selectivity indices were calculated for ethyl acetate and methanol extract as 3.32 and 13.39, respectively. All extracts displayed Deoxyribonucleic Acid (DNA) protection activity at approximately 25%–35%. For cell viability evaluation, 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) test was performed against triple-negative human breast adenocarcinoma cells (MDA-MB-231) and Michigan Cancer Foundation-7 (MCF-7) cells. The most effective results were found in ethyl acetate extract at 48h. The 50% inhibitor concentrations (IC50) were determined for MDA-MB-231 and MCF-7 as 116.7 μg/mL and 247.9 μg/mL, respectively. Based on the bioactive compound content results, extracts of H. humile include valuable compounds that possess significant biological properties. In conclusion, these extracts could offer promising novel plant-derived therapeutics.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2024Scopus SJRQ1
    Morphometric characteristics of glacial cirques and former glaciers in the Geyik Mountains, Western Taurus, Türkiye

    Çılğın, Zeynel; Evans, Ian S.; Keserci, Ferhat; Canpolat, Ergin; Bayrakdar, Cihan

    Using the Glacier reconstruction (GlaRe) toolbox, reconstructions of former glaciers in the Geyik Mountains, part of the Taurus Mountain system in southern Türkiye, show that an area of 132.5 km2 was glaciated in the last major glaciation, which left clear terminal and hummocky moraines. Glaciers were 1.4 to 12 km long and those from 49 cirques merged to form a broad 75 km2 piedmont glacier in the Namaras Valley, up to 400 m thick. A thorough analysis of morphometry of the 98 Geyik cirques, using the revised Automated Cirque Metric Extraction version 2 (ACME2) toolbox, shows that they are relatively small, with limited widths: the median length/width ratio of 1.29 is unusually high. With size, length and width increase faster than depth, demonstrating strong static allometry. Maximum slope averages 59°, minimum 3.3° and axial 25°. A combination of low hypsometric integral, high axial profile closure and high axial height-length integral is proposed as a measure of cirque development. The main summits are on sharp ridges on cirque crests, showing that they have been lowered by glacial erosion (by cirque development). Glaciation was strongly asymmetric, with cirque vector mean aspect between northeast and north-northeast. This shows the dominance of solar radiation effects, with some modification from westerly winds. Glacier palaeo- Equilibrium Line Altitudes (pELAs) rise northeastwards and cirque floor minimum altitudes (CFAs) rise toward east-northeast, both showing the importance of moist air from the Mediterranean, 38–55 km to the southwest. pELA averages 2208 m above sea level (a.s.l.) (2277 m area-weighted); CFA averages 2234 m. CFA varies mainly with summit altitudes; where related palaeoglaciers are short CFA is somewhat below pELA, but for longer ones it is above. The most likely palaeoclimate to form these glaciers involves a precipitation increase of 53–72 % with a temperature fall of 8 °C compared with present-day. The cirques formed under similar or less severe conditions.

    • SDG 13 · İklim Eylemi
    AtıfScopus7OpenAlex15
    Scopusİncele
  • MakaleAçık Erişim2024Scopus SJRQ1
    A new hybrid approach for grapevine leaves recognition based on ESRGAN data augmentation and GASVM feature selection

    Doğan, Gürkan; Imak, Andaç; Ergen, Burhan; Sengur, Abdulkadir

    Grapevine leaf is a commodity that is collected only once a year and has a high return on investment due to its export. However, only certain types of grapevine leaves are consumed. Therefore, it is extremely important to distinguish the types of grapevine leaves. In particular, performing this process automatically on industrial machines will reduce human errors, workload, and thus cost. In this study, a new hybrid approach based on a convolutional neural network is proposed that can automatically distinguish the types of grapevine leaves. In the proposed approach, firstly, the overfitting of network models is prevented by applying data augmentation techniques. Second, new synthetic images were created with the ESRGAN technique to obtain detailed texture information. Third, the top blocks of the MobileNetV2 and VGG19 CNN models were replaced with the newly designed top block, effectively extracting features with the data. Fourthly, the GASVM algorithm was adapted and used to create a subset of the features to eliminate the ineffective and unimportant ones from the obtained features. Finally, SVM classification was performed with the feature subset consisting of 314 features, and approximately 2% higher accuracy and MCC score were obtained compared to the approaches in the literature.

    • SDG 2 · Açlığa Son
    AtıfScopus8WoS6OpenAlex9
    ScopusWeb of Scienceİncele
  • MakaleYalnız künye2024Scopus SJRQ2
    A new S-box generator algorithm based on chaos and cellular automata

    Artuğer, Fırat

    S-boxes are very important structures for encryption algorithms. For S-boxes to be strong, they should not be as linear as possible. Obtaining an S-box with high nonlinearity is a difficult problem. For this reason, it has attracted the attention of researchers for many years. In this study, cellular automata logic was used to overcome this problem. A chaotic tent map was used for the initial population. Then, in this weak S-box, the elements were replaced with their neighbors, and the nonlinearity value was checked. When this value increased, the S-box was transferred to the next generation. With the proposed algorithm, an S-box structure with a nonlinearity value of 110.5 was obtained. This value surpasses most studies in the literature. In addition, it has been proven because of the analysis that the proposed S-box also provides other performance criteria.

    AtıfScopus6WoS8OpenAlex7
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  • MakaleAçık Erişim2024Scopus SJRQ1
    Experimental and theoretical results of gamma shielding features for copper based shape memory alloys

    Niksarlıoğlu, Seçil; Akman, Ferdi; Agar, Osman; Kaçal, Mustafa Recep; Kanca, Muhammed Sait

    In this study, the gamma ray attenuation characteristics for CuAlNi shape memory alloys with different proportions of Sn doping was investigated. We determined the mass attenuation coefficient (μ/ρ) of CuAlNiSn alloys both experimentally and theoretically within an energy range of 59.5–1332.5 keV. The experimental measurements were made using a high purity Germanium detector (HPGe) and theoretical calculations were made using WinXCOM program. To evaluate the gamma radiation shielding abilities of the alloy samples, the obtained (μ/ρ) values were used to determine the gamma protection parameters μ, HVL, TVL, MFP, and Zeff. In addition, the radiation protection efficiency (RPE) parameter was determined using gamma ray intensities in the absence and presence of the attenuator. Further analysis of the samples was conducted using a Rigaku Miniflex 600 model computer-controlled X-ray diffractometer (CuKα & λ = 1.5405 A0). The crystallographic structure of the alloys before and after irradiation was investigated. Other analysis which include EDX analysis (to investigate the chemical content) and SEM analysis (to investigate the microstructure) were conducted. According to result outcomes, gamma ray radiation did not affect the shape memory properties of structure. Another interesting observation is that, the radiation attenuation properties increase with increasing Sn concentration. Finally, we discovered that the CuAlNiSn4 alloy (which has the highest doping rate) provides good protection especially at low energy levels.

    AtıfScopus5OpenAlex6
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  • MakaleAçık Erişim2024Scopus SJRQ2
    Effects of naringenin on oxidative damage and apoptosis in liver and kidney in rats subjected to chronic mercury chloride

    Kahramanoğullari, Merve; Erişir, Mine; Yaman, Mine; Parlak Ak, Tuba

    Mercury chloride is a type of heavy metal that causes the formation of free radicals, causing hepatotoxicity, nephrotoxicity and apoptosis. In this study, the effects of naringenin on oxidative stress and apoptosis in the liver and kidney of rats exposed to mercury chloride were investigated. In the study, 41 2-month-old male Wistar-Albino rats were divided into five groups. Accordingly, group 1 was set as control group, group 2 as naringenin-100, group 3 as mercury chloride, group 4 as mercury chloride + naringenin-50, and group 5 as mercury chloride + naringenin-100. For the interventions, 1 mL/kg saline was administered to the control, 0.4 mg/kg/day mercury (II) chloride to the mercury chloride groups by i.p., and 50 and 100 mg/kg/day naringenin prepared in corn oil to the naringenin groups by gavage. All the interventions lasted for 20 days. Mercury chloride administration was initiated 1 h following the administration of naringenin. When mercury chloride and the control group were compared, a significant increase in plasma urea, liver and kidney malondialdehyde (MDA) levels, in kidney superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) activities (p <.001), and a significant decrease in liver and kidney glutathione (GSH) levels (p <.001), in liver catalase (CAT) activity (p <.01) were observed. In addition, histopathological changes and a significant increase in caspase-3 levels were detected (p <.05). When mercury chloride and treatment groups were compared, the administration of naringenin caused a decrease aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH) (p <.01), urea, creatinine levels (p <.001) in plasma, MDA levels in liver and kidney, SOD, GSH-Px, GST activities in kidney (p <.001), and increased GSH levels in liver and kidney. The addition of naringenin-100 increased GSH levels above the control (p <.001). The administration of naringenin was also decreased histopathological changes and caspase-3 levels (p <.05). Accordingly, it was determined that naringenin is protective and therapeutic against mercury chloride-induced oxidative damage and apoptosis in the liver and kidney, and 100 mg/kg naringenin is more effective in preventing histopathological changes and apoptosis.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus13WoS14OpenAlex14
    ScopusWeb of SciencePubMedİncele
  • MakaleYalnız künye2024Scopus SJRQ2
    Molecular characterization of apple endophytic bacteria and biological effect on Alternaria rot on apple

    Bektas, Idris; Yazdıc, Ferit Can; Kusek, Mustafa

    Apple rot disease, caused by Alternaria alternata, is causing significant losses in apple production, especially in post-harvest periods. Alternaria alternata, was isolated from rotten apple fruit of cv Amasya. Identification of the strain isolated from rotten apple fruit was made by ITS sequence and morphological analysis. In the present study, 58 different endophytic bacteria strains were isolated from apple fruit for use in apple rot disease control. Among the isolated strains, 26 endophyte strains were determined to inhibit the radial growth of mycelia of A. alternata in binary culture in PDA media. Based on 16S rRNA sequencing analysis, these antagonistic endophytic bacteria strains were identified as Bacillus ssp. Bacillus methylotrophicus (ib17) showed the highest significant inhibitory effect on the mycelial growth of A. alternata at a rate of 79.5% in PDA medium. The results of in vivo experiments showed that Bacillus licheniformis (ib20) achieved 100% biocontrol when endophyte bacterial strains were inoculated 24 h before the inoculation of A. alternata. When the three bacteria species and A. alternata were inoculated simultaneously, Bacillus myloliquefaciens (ib1), Bacillus licheniformis (ib21) and the Endophytic bacterium (ib16) showed the highest biocontrol efficacy against A. alternata at 81.8%. Furthermore, when the bacterial strains were inoculated at 24 h after inoculation of A. alternata, B. licheniformis (ib21) showed the highest biocontrol efficacy of 83.3% against the fungal pathogen compared to the controls. The endophytic bacterial strains produced fungal cell wall hydrolysing enzymes such as chitinase, cellulase, amylase and protease. According to the results of this study, apple endophytic bacteria are potential candidates to control apple decay caused by A. alternata through cell wall hydrolysing enzymes and reduce disease severity. However, the efficacy of the biological control was dependent on the applied time of epiphytic bacterial strains. Further research is needed on the biochemical mechanisms underlying the activity of these bacteria against A. alternata.

    • SDG 2 · Açlığa Son
    AtıfScopus7WoS7OpenAlex9
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  • MakaleYalnız künye2024Scopus SJRQ3
    Biogenic Silver and Zinc Enhanced MWCNTs: Nano-Decoration, Characterization, and Antimicrobial Effect

    Ünal, İlkay

    In this study, acid-treated multi-walled carbon nanotubes (MWCNTs) were decorated with silver (Ag), zinc (Zn), and Ag@Zn nanoparticles (NPs) synthesized using plant extract for reducing and stabilizing NPs. The nanocomposites were characterized by Scanning electron microscopy (SEM)-energy-dispersive X-ray spectroscopy (EDX), Transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, and Thermogravimetric analysis (TGA). The stability of functionalized MWCNTs (f-MWCNTs) and NP-decorated MWCNTs was visually evaluated for seven days in ethanol. The antimicrobial efficacy against Gram-positive (Staphylococcus aureus), Gram-negative (Pseudomonas aeruginosa, Escherichia coli) bacteria, and fungi (Candida albicans) was determined using the agar well diffusion assay. Results indicated that Ag-MWCNTs and Ag@Zn-MWCNTs nanocomposites exhibited superior antimicrobial activity against P. aeruginosa and C. albicans compared to other tested microorganisms. Conversely, f-MWCNTs and Zn-MWCNTs showed no antimicrobial effects.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus1WoS1OpenAlex1
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2024Scopus SJRQ3
    Toxicity assessment of advanced biological wastewater treatment plant effluent by integrated biomarker response in zebra mussels (Dreissenapolymorpha)

    Serdar, Osman; Ketenalp, Zozan; Yildirim, Nuran Cikcikoglu

    In this study, zebra mussels (Dreissena polymorpha) were exposed to advanced biological wastewater treatment plant effluent (ABWTPE) for 96 h. At the end of the 96th hour, antioxidant parameters such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione S-transferase (GST), malondialdehyde (MDA) and glutathione (GSH) were examined. The objective of the study was to identify biomarkers that are useful for assessing the potential toxic effects of ABWTPE in freshwater environments. We observed an increase in GPX, SOD activity and MDA levels, and a decrease in CAT, GST activity and GSH levels. The results obtained in our study showed that the measured biochemical parameters (GSH, MDA, SOD, CAT, GPX and GST) are useful biomarkers in determining the possible toxicity of ABWTPE in aquatic environments.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    • SDG 6 · Temiz Su ve Sanitasyon
    • SDG 14 · Sudaki Yaşam
    AtıfScopus3WoS3OpenAlex3
    ScopusWeb of Scienceİncele
  • MakaleYalnız künye2024Scopus SJRQ1
    Preparation and characterization of the highly efficient tetraphenylimidazole substituted Phthalocyanine/ZnO composite and investigation of its effect on the photocatalytic degradation of Rhodamine B and 2,4,6-trichlorophenol

    Karaoğlu, Kaan; Yüzüak, Gizem Durak; Yüzüak, Ercüment; Turan, Hanife; Akçay, Hakkı Türker

    Growing concerns about industrial waste-induced environmental degradation have driven research towards sustainable solutions. Photocatalytic degradation, fueled by light and avoiding harmful chemicals, offers a promising avenue due to its minimal environmental impact. ZnO, TiO₂, and their derivatives are particularly effective and widely studied photocatalysts. This study aims to prepare new composite materials bearing phthalocyanine and investigate the photocatalytic properties on the degradation of Rhodamine B dye and 2,4,6-trichlorophenol (TCP) as the model compounds. In the initial step, ZnO materials were synthesized using the solvothermal method. Subsequently, a novel Zn(II) complex, including peripherally tetra phenyl imidazole substituted phthalocyanine, was successfully prepared. The composite catalysts were prepared from ZnO materials produced with the tetraphenyl imidazole phthalocyanine Zn(II) complex, called TFI-Zn. The were characterized using instrumental techniques. The photocatalytic characteristics of the composite materials developed were further examined under varying quantities of catalyst and Rhodamine B, variable pH conditions, and varying intensities of UV-A light. In addition, the reusability of the catalyst was investigated. With the new composite photocatalyst prepared within the scope of this study, 98% degradation efficiency and 8.0 × 10−4 min−1 degradation rate was obtained on Rhodamine B solution in 40 min. The newly developed photocatalyst displayed remarkable catalytic activity that remained virtually unchanged for five consecutive cycles, indicating excellent reusability and operational stability. The photocatalytic degradation performance of ZnO-TFI-Zn (1) was also examined on TCP and 90% degradation activity was obtained at the end of 80 min.

    • SDG 6 · Temiz Su ve Sanitasyon
    • SDG 12 · Sorumlu Üretim ve Tüketim
    AtıfScopus7WoS7OpenAlex7
    ScopusWeb of Scienceİncele
  • MakaleYalnız künye2024Scopus SJRQ1
    Resistance to magnesium sulphate attack of binary and ternary cementless self-compacting alkali-activated mortar

    Şahin Yön, Merve; Karataş, Mehmet

    The aim of this study is to investigate the effect of sulphate on self-compacting alkali-activated mortars (SCAAMs) produced using volcanic scoria (V), boron waste (B) and granulated blast furnace slag (G) together with alkali activators. Thus, the production of cement-free alkali-active mortar by recycling waste and reducing the CO2 effect increases the importance of this study. The fact that the waste material is provided free of charge and that V is readily available from nature provides economic advantages in the production of these mortars. In this experimental study, magnesium sulphate solution was utilized to define the sulphate resistance of SCAAMs. In binary SCAAMs, B was used with G in a ratio of NS:NH = 3.0, with an increase from 5 % to 15 %; in ternary mixtures, B was used together with G and V in the same proportions, in a ratio of NS:NH = 1.0. The tests involved immersion in 5 % magnesium sulphate solution for 1, 3 and 6 months. Mass development, compressive strength, visual inspection and microstructural changes were investigated. In general, the binary SCAAMs performed better in magnesium sulphate solution than the ternary SCAAMs, except in the 6th month. Considering the samples with the highest B content, a 100 % loss of compressive strength occurred in the B15G85 sample under the influence of sulphate for 6 months, while a loss of compressive strength of about 15 % occurred in the B15G40V45 sample. The results showed that the increase in B content caused a severe deterioration of the sulphate effect in the samples over time and that the V additive had a positive effect on the sulphate resistance.

    • SDG 12 · Sorumlu Üretim ve Tüketim
    AtıfScopus26WoS23OpenAlex19
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2024Scopus SJRQ1
    Impact of a Novel Valerian Extract on Sleep Quality, Relaxation, and GABA/Serotonin Receptor Activity in a Murine Model

    Sahin, Kazim; Gencoglu, Hasan; Korkusuz, Ahmet Kayhan; Orhan, Cemal; Aldatmaz, İsmail Ertuğ; Erten, Fusun; Er, Besir; Morde, Abhijeet; Padigaru, Muralidhara; Kilic, Ertugrul

    Insomnia is a major global health issue, highlighting the need for treatments that are both effective and safe. Valerian extract, a traditional remedy for sleep problems, offers potential therapeutic options. This research examined the potential sleep-enhancing effects of VA (Valerian Pdr%2) in mice. The study evaluated sleep quality by comparing the impact of the VA extract against melatonin on brain activity, using electrocorticography (ECoG) to assess changes in brain waves. For this purpose, the study utilized two experimental models on BALB/c mice to explore the effects of caffeine-induced insomnia and pentobarbital-induced sleep. In the first model, 25 mice were assigned to five groups to test the effects of caffeine (caffeine, 7.5 mg/kg i.p) alone, caffeine with melatonin (2 mg/kg), or caffeine with different doses of valerian extract (100 or 300 mg/kg) given orally on brain activity, assessed via electrocorticography (ECoG) and further analyses on the receptor proteins and neurotransmitters. In the second model, a different set of 25 mice were divided into five groups to examine the impact of pentobarbital (42 mg/kg) alone, with melatonin, or with the valerian extract on sleep induction, observing the effects 45 min after administration. The study found that ECoG frequencies were lower in groups treated with melatonin and two doses of valerian extract (100 and 300 mg/kg), with 300 mg/kg showing the most significant effect in reducing frequencies compared to the caffeine control group, indicating enhanced sleep quality (p < 0.05). This was supported by increased levels of serotonin, melatonin, and dopamine and higher levels of certain brain receptors in the melatonin and valerian extract groups (p < 0.05). Modulatory efficacy for the apoptotic markers in the brain was also noted (p < 0.05). Additionally, melatonin and both doses of VA increased sleep duration and reduced sleep onset time compared to the pentobarbital control, which was particularly notable with high doses. In conclusion, the findings suggest that high doses (300 mg/kg) of valerian extract enhance both the quantity and quality of sleep through the GABAergic pathway and effectively increase sleep duration while reducing the time to fall asleep in a pentobarbital-induced sleep model in mice.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    AtıfScopus19OpenAlex19
    ScopusWeb of SciencePubMedİncele