Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Gul, Muhammet(82)
- Akkurt, Nevzat(67)
- Güler, Ömer(66)
- Baskonus, Haci Mehmet(62)
- Bulut, Hasan(60)
- Tekin, H.O.(52)
- ALMisned, Ghada(49)
- Yucesan, Melih(43)
- Yildirim, Numan(42)
- Yildirim, Nuran Cikcikoglu(38)
- Paksoy, Mehmet Yavuz(36)
- Serdar, Osman(36)
- Zengin, Gokhan(36)
- Ince, Muharrem(34)
- Celik, Erkan(33)
- Benzer, Fulya(32)
- Kocabaş, Mehmet(30)
- Sulaiman, Tukur Abdulkadir(30)
- Tanyol, Mehtap(29)
- Yildirim, Ozal(28)
- Aslan, Naim(26)
- Kök, Mediha(26)
- Özkul, İskender(26)
- Ates, Mehmet(25)
- Danabas, Durali(25)
- Kutluyer, Filiz(25)
- Can, Erkan(24)
- Kutlu, Banu(23)
- Onat, Onur(23)
- Demir, Veysel(22)
- Erten, Fusun(22)
- Guler, Omer(22)
- Say, Yakup(22)
- Güler, Seval Hale(21)
- Yaman, Mehmet(21)
- Baykal, Duygu Sen(20)
- Sançar, Taylan(20)
- Susam, Selim Orhun(20)
- Cakilcioglu, Ugur(19)
- Orhan, Cemal(19)
Yayınlar
- MakaleAçık Erişim2019Scopus SJRQ4α-D-glucopyranosyl-(1→2)-[6-O-(L-tryptophanyl)-β-D-fructofuranoside]
Kyeremeh, Kwaku; Kwain, Samuel; Tetevi, Gilbert Mawuli; Camas, Anil Sazak; Camas, Mustafa; Dofuor, Aboagye Kwarteng; Deng, Hai; Jaspars, Marcel
The Mycobacterium sp. BRS2A-AR2 is an endophyte of the mangrove plant Rhizophora racemosa G. Mey., which grows along the banks of the River Butre, in theWestern Region of Ghana. Chemical profiling using 1H-NMR and HRESI-LC-MS of fermentation extracts produced by the strain led to the isolation of the new compound, α-D-Glucopyranosyl-(1→2)-[6-O-(L-tryptophanyl)-β- D-fructofuranoside] or simply tortomycoglycoside (1). Compound 1 is an aminoglycoside consisting of a tryptophan moiety esterified to a disaccharide made up of β-D-fructofuranose and α-D-glucopyranose sugars. The full structure of 1 was determined using UV, IR, 1D, 2D-NMR and HRESI-LC-MS data. When tested against Trypanosoma brucei subsp. brucei, the parasite responsible for Human African Trypanosomiasis in sub-Saharan Africa, 1 (IC50 11.25 µM) was just as effective as Coptis japonica (Thunb.) Makino. (IC50 8.20 µM). The extract of Coptis japonica (Thunb.) Makino. is routinely used as laboratory standard due to its powerful antitrypanosomal activity. It is possible that, compound 1 interferes with the normal uptake and metabolism of tryptophan in the T. brucei subsp. brucei parasite.
AtıfScopus2WoS2OpenAlex2
İncele - Derleme MakaleYalnız künye2019Scopus SJRQ1Designing the airport service with fuzzy QFD based on SERVQUAL integrated with a fuzzy multi-objective decision model
Kayapınar, Sema; Erginel, Nihal
Airport service quality is a crucial issue in the transportation industry. Although many studies focus on service quality and measurement of the airports, only a small number of studies that consider linguistic expression and fuzzy approach exist in the literature. This study aims to propose a new integrated approach to develop airport service quality. An integrated approach involving fuzzy Quality Function Deployment (QFD) based on SERVQUAL is used to measure airport service quality and to determine fuzzy weights of technical design requirements. Firstly, passengers’ needs are prioritised by using the SERVQUAL method and gap scores, then QFD matrix is constructed by defining fuzzy relationships between passengers’ needs and expectations, and technical design requirements under imprecise knowledge. Technical design requirements are weighted by using fuzzy QFD matrix as fuzzy numbers. Finally, a fuzzy multiple objective decision model is proposed to select the significant technical design requirements with two objectives: maximising the total fuzzy weights of technical design requirements and minimising the fuzzy technical difficulty level under a fuzzy budget constraint. A two-phase approach is used to solve the constructed fuzzy multi-objective decision model. The final results indicate four design requirements named as ‘the number of information board’, ‘capacity of wi-fi’, ‘emergency help button and automation’, and ‘the number of the signboard’, which maximise the total fuzzy weights of technical design requirements and minimise the sum of the fuzzy technical difficulty of each design requirements under the fuzzy budget constraint. This study is a real-world application which was implemented at the Anadolu University Airport in Turkey.
AtıfScopus40WoS37OpenAlex47İncele - MakaleYalnız künye2019Scopus SJRQ3Effect of L-Tryptophan on Sperm Quality of Tigris Scraper (Capoeta umbla) (Pisces: Cyprinidae) after Cryopreservation
Kutluyer, F.; Aksu, Ö.; Kocabaş, M.
BACKGROUND: The aromatic amino acid L-tryptophan is a versatile molecule and needed for the biosynthesis of proteins. Due to metabolic functions, it has been widely used in research and clinical trials. OBJECTIVE: The present study aimed to test the usefulness of L-tryptophan as an extender of Tigris scraper (Capoeta umbla) sperm during cryopreservation. MATERIALS AND METHODS: Semen samples were diluted with a ratio of 1:3 (sperm: extender) and base extenders were supplemented with L-tryptophan (0 mM, 0.5 mM, 1 mM, 2 mM and 4 mM). Sperm motility and duration of post-thawed samples were assessed after the cryopreservation process. RESULTS: Our results revealed that motility rate and duration of sperm increased when the cryomedia was supplemented with L-tryptophan. On the other hand, an increase in the concentration of L-tryptophan in the extender caused a significant decrease (p<0.05) in the motility rate of Tigris scraper (C. umbla) sperm. The ideal results were obtained at 1 mM L-tryptophan; however, no motile sperm were shown in any samples when a concentration of 2 mM was used. CONCLUSION: The current study shows the importance of conducting further studies related to long-term storage and reproduction management.
AtıfScopus12WoS12
İncele - MakaleAçık Erişim2019Scopus SJRQ3Karyological investigation on five taxa of Bellevalia lapeyr. (Asparagaceae) from Turkey
Dogan, Gulden; Kiran, Yasar; Yavuz Paksoy, M.
The somatic chromosome numbers and karyotypes were examined in five Bellevalia taxa including two endemic species of B. chrisii and B. gracilis distributed in Turkey. The chromosome numbers were determined as 2n=2x=8 in all studied taxa [B. chrisii Yıldırım & B. Şahin sp. nov., B. glauca (Lindl.) Kunth., B. gracilis Feinbrun, B. longipes Post, B. sarmatica (Pallas ex Georgi) Woronow]. The karyotype formula was determined as 2m+sm+st in B. chrisii and B. longipes, 3m+st in B. glauca, B. gracilis and B. sarmatica. The findings for each of the analyzed taxa are compared with the results of previous studies.
- MakaleYalnız künye2019Scopus SJRQ3Utilizing hydrolyzed powder recyclates as filler in polystyrene; [Verwendung von hydrolisierten Pulverlackrecyclaten als Füllstoff in Polystyrol]
Kismet, Y.; Wagner, M.H.
In the present study, hydrolyzed powder coating wastes were used as filler materials in polystyrene compounds, and the effect on the mechanical properties, melt flow index and density of polystyrene compounds were investigated. Epoxy/polyester, epoxy and polyurethane systems with thermoset structure were used as powder coating recyclates. After separately hydrolyzing these wastes, 5 %, 10 %, 20 % and 30 % by weight were homogeneously mixed with polystyrene, initially mechanically and subsequently with an extruder in the melt at 180 °C. The resulting compounds were cooled and granulated, and by use of an injection molding machine at 180 °C to 200 °C, standard tensile test bars were produced. Tensile strength, bending strength and izod impact strength of the test bars were measured and the variations of the mechanical properties of the polystyrene compounds as a function of the type and amount of filler were examined. In addition, melt flow index and density of the compounds were determined. Furthermore, the bonding mechanism of filler and matrix material was examined by electron microscopy.
AtıfScopus2WoS2OpenAlex3İncele - MakaleYalnız künye2019Scopus SJRQ1Risk evaluation and prevention in hydropower plant operations: A model based on Pythagorean fuzzy AHP
Yucesan, Melih; Kahraman, Gökhan
Hydropower generation facilities are becoming increasingly popular in many parts of the world. One of the main reasons for this situation is that the resource reserves such as coal, petroleum and natural gas, which are called conventional energy sources, decrease day by day and their prices rise. So the efficient operation of hydroelectric power plants has become very important. When these plants are operated, it is possible to cause many hazards, including injury, illness, death, damage to the environment, property and equipment. In this study, it is aimed to perform risk assessment for hydroelectric power plants using Pythagorean fuzzy Analytical hierarchy process (PFAHP) method. The team of experts has identified twenty hazards and their results that could occur in the operation of the hydroelectric power plant. The weights of the hazards were determined by using linguistic expressions. Preventive measures have been taken for the three most important hazards. The results of this study are expected to contribute to the safety of hydropower plants and the prevention of financial losses.
AtıfScopus143WoS123OpenAlex147İncele - MakaleAçık Erişim2019Scopus SJRQ2Ultrasound as pretreatment for drying garlic slices in microwave and convective dryer
Bozkir, Hamza; Rayman Ergün, Ahsen; Tekgül, Yeliz; Baysal, Taner
The effects of ultrasound pretreatment (US) before hot air drying (HAD) and microwave drying (MWD) of garlic slices were investigated. For this aim ultrasonic bath at 30 °C for 30 min (35 kHz), microwave oven at 540 W power and tray dryer at 60 °C and with 1.0 m/s air flow rate were used to reach the final moisture content of 5%. Drying rate increased in the US + HAD and the US + MWD groups by 19.30% and 13.82% respectively in comparison with control groups. The effective moisture diffusivity (D eff ) of garlic slices were calculated from Fick’s diffusion model for the HAD, US + HAD, MWD and the US + MWD groups as 1.420 × 10 −10 , 1.826 × 10 −10 , 1.177 × 10 −8 , 1.363 × 10 −8 m 2 /s respectively. The rehydration rates increased, and bulk densities were decreased in the US + HAD and the US + MWD compared to the control groups. The color values were significantly affected after ultrasound pretreatment. Redness, and yellowness increased most in the US + HAD group.
AtıfScopus53WoS47OpenAlex58İncele - MakaleAçık Erişim2019Scopus SJRQ4Digyaindoleacid A: 2-(1-(4-hydroxyphenyl)-3-oxobut-1-en-2-yloxy)-3-(1H-indol-3-yl)propanoic acid, a novel indole alkaloid
Kwain, Samuel; Tetevi, Gilbert Mawuli; Mensah, Thomas; Camas, Anil Sazak; Camas, Mustafa; Dofuor, Aboagye Kwarteng; Azerigyik, Faustus Akankperiwen; Deng, Hai; Jaspars, Marcel; Kyeremeh, Kwaku
Digyaindoleacid A (1) is one of the novel alkaloids produced by the Ghanaian Paenibacillus sp. DE2SH (GenBank Accession Number: MH091697) isolated from the mangrove rhizosphere soils of the Pterocarpus santalinoides tree growing in the wetlands of the Digya National Park, Brong Ahafo Region, Ghana. This compound was isolated on HPLC at tR ≈ 60 min and its structure determined by MS, 1D, and 2D-NMR data. When tested against Trypanosoma brucei subsp. brucei strain 927/4 GUTat10.1, 1 produced a half-maximal inhibitory concentration (IC50) 5.21 µM compared to the standard diminazene aceturate (IC50 = 1.86 µM). In the presence of normal mouse macrophages RAW 264.7, 1 displayed a higher selectivity towards T. brucei subsp. brucei (selectivity indices (SI) = 30.2) with low toxicity. This result is interesting given that the drug diminazene aceturate is considerably toxic and 1 is a natural product isolate. The structure of 1 incorporates the backbone of the amino acid tryptophan which is crucial in the metabolism of Trypanosoma brucei subsp. brucei strain 927/4 GUTat10.1. It is possible that 1, could interfere with the normal uptake and metabolism of tryptophan in the parasite. However, 1 (IC50 = 135.41 µM) produced weak antileishmanial activity when tested against Leishmania donovani (Laveran and Mesnil) Ross (D10).
AtıfScopus4WoS3OpenAlex4İncele - MakaleYalnız künye2019Scopus SJRQ1Flow past a hollow cylinder with two spanwise rows of holes
Firat, Erhan; Ozkan, Gokturk M.; Akilli, Huseyin
Abstract: The flow over fixed, hollow, rigid circular cylinders with and without two series of equally spaced holes of equal diameter (0.2 cylinder diameter) along the surface of the cylinder has been studied by means of dye injection flow visualization, particle image velocimetry (PIV), and force measurements. Holes are connecting the front and rear stagnation lines or the upper and lower sides (i.e., they are positioned at ± 90° from the stagnation line) of the cylinder. The center-to-center distance between holes was 7-hole diameter. The experimental data were obtained from water channel and wind tunnel measurements performed at Reynolds numbers of 6900 and 20000, respectively. It was found that cylinder with holes located on the surface at an angle ± 90° from the front stagnation line behaves like a double-chamber synthetic jet actuator when subjected to cross-flow. The interaction of synthetic jet arrays with external flow over the side surfaces instigates the three-dimensional instabilities in the near wake and produces a 14.4% drag reduction compared to the drag of a plain cylinder. It was shown that cylinder with holes located on the surface at angles of 0° and 180° from the front stagnation line also instigates the three-dimensional instabilities in the near wake, but the primary mechanism responsible for drag reduction is self-bleed through downstream holes. This system producing drag reduction was found to have a drag coefficient equal to about 78.9% of that for a plain cylinder. Important flow structures inside and behind the cylinders with holes were also identified. Graphic abstract: [Figure not available: see fulltext.].
AtıfScopus17WoS17OpenAlex16İncele - MakaleYalnız künye2019Scopus SJRQ2A rearranged homoploid hybrid species of Origanum (Lamiaceae): O. ×munzurense Kit Tan & Sorger
Dirmenci, Tuncay; Özcan, Taner; Açar, Mikail; Arabacı, Turan; Yazıcı, Türker; Martin, Esra
Origanum munzurense Kit Tan & Sorger (Sect. Brevifilamentum Ietsw.) was described by Kit Tan & Sorger in 1984, and it is an accepted species related to O. acutidens (Hand.-Mazz.) Ietsw. belonging to sect. Brevifilamentum. It is morphologically intermediate between O. acutidens and O. vulgare L. subsp. gracile (K.Koch) Ietsw., and its type locality lies in the overlap zone between the geographic distributions of these two taxa. We hypothesized that O. munzurense is in fact a hybrid between the two aforementioned taxa and we tested this hypothesis with the general morphology, chromosome features, and nuclear (ITS1–ITS2) and chloroplast (rpl32) DNA sequences of specimens of O. munzurense and its putative parental species, O. vulgare subsp. gracile and O. acutidens. The somatic chromosome number of O. munzurense, O. vulgare subsp. gracile and O. acutidens were counted as 2n = 30. Origanum munzurense presented polymorphic sites in the nuclear ITS region, but the chloroplast markers did not allow us to identify the putative maternal of O. munzurense. Our results suggest that O. munzurense is indeed a hybrid, and its rearrangement as a new homoploid hybrid (O. ×munzurense) would be more accurate. These present results support previous reports for the speciation of Origanum members via hybridization.
AtıfScopus23OpenAlex10İncele - MakaleAçık Erişim2019Scopus SJRQ4Investigation of relaxation times in 5-fluorouracil and human serum albumin mixtures
Korunur, Sibel; Zengin, Bilgin; Yilmaz, Ali
Background: Human serum albumin (HSA) is often selected as a subject of any study because albumin is the most abundant protein in human blood plasma. NMR is recognized as a valuable method to determine the structure of proteins-ligand and protein-drug complexes. Objective - Aim of the study: In this study, protein drug interactions were investigated using 5-Fluorouracil anticancer drug and human serum albumin protein. Materials and methods: In this context 400 MHz NMR spectrometry was used and NMR relaxation rates in drug-albumin complex were investigated with respect to increase albumin concentration and increase in 5-Fluoro-uracil (5-FU)-albumin solution temperature. Results: The results of this study indicated that 5-FU had a weak association with albumin, and it easily dissociated from the protein to which it was attached. Conclusion: The obtained results also gave us useful information about molecular dynamics of drug-albumin interactions.
AtıfScopus4WoS3OpenAlex4TR Dizin1
İncele - MakaleAçık Erişim2019Scopus SJRQ3Hybrid parliamentary optimization and big bang-big crunch algorithm for global optimization
Kiziloluk, Soner; Özer, Ahmet Bedri
Researchers have developed different metaheuristic algorithms to solve various optimization problems. The efficiency of a metaheuristic algorithm depends on the balance between exploration and exploitation. This paper presents the hybrid parliamentary optimization and big bang-big crunch (HPO-BBBC) algorithm, which is a combination of the parliamentary optimization algorithm (POA) and the big bang-big crunch (BB-BC) optimization algorithm. The intragroup competition phase of the POA is a process that searches for potential points in the search space, thereby providing an exploration mechanism. By contrast, the BB-BC algorithm has an effective exploitation mechanism. In the proposed method, steps of the BB-BC algorithm are added to the intragroup competition phase of the POA in order to improve the exploitation capabilities of the POA. Thus, the proposed method achieves a good balance between exploration and exploitation. The performance of the HPO-BBBC algorithm was tested using well-known mathematical test functions and compared with that of the POA, the BB-BC algorithm, and some other metaheuristics, namely the genetic algorithm, multiverse optimizer, crow search algorithm, dragonfly algorithm, and moth-flame optimization algorithm. The HPO-BBBC algorithm was found to achieve better optimization performance and a higher convergence speed than the above-mentioned algorithms on most benchmark problems.
AtıfScopus3WoS1OpenAlex3İncele - MakaleAçık Erişim2019Scopus SJRQ3Bioactivity-guided isolation of anti-inflammatory principles from Cistus parviflorus Lam.
Gürbüz, Perihan; Doğan, Şengül Dilem; Çelik, Gizem Nur; Bekci, Hatice; Cumaoğlu, Ahmet; Gündüz, Miyase Gözde; Paksoy, Mehmet Yavuz
Bioactivity-guided fractionation and purification of Cistus parviflorus led to the isolation of two flavan-3-ol derivatives; gallocatechin (1) and epigallocatechin (2) and two flavonoid glycosides; avicularin (3) and trans-tiliroside (4). The structures of the compounds were elucidated on the basis of NMR and ESIMS data. All compounds were isolated from C. parviflorus for the first time. Compounds 2 and exhibited antiinflammatory activity through decreasing the NOS2 and COX2 levels on LPS+IFN-γ treated RAW 264.7 cells. Molecular docking studies of avicularin, the most potent compound, were carried out in the active sites of NOS2 and COX2 to predict the most plausible binding modes and support the experimental data.
AtıfScopus7OpenAlex8TR Dizin2İncele - MakaleYalnız künye2019Scopus SJRQ1Deep long short-term memory networks-based automatic recognition of six different digital modulation types under varying noise conditions
Daldal, Nihat; Yıldırım, Özal; Polat, Kemal
In this paper, a new method based on deep learning has been proposed in order to recognize noise-digital modulation signals at varying noise levels automatically. The 8-bit data from six different modulations have been obtained by adding noise levels from 5 to 25 dB. The used digital modulation types are Amplitude Shift Keying, Frequency Shift Keying, Phase Shift Keying, Quadrature Amplitude Shift Keying, Quadrature Frequency Shift Keying, and Quadrature Phase Shift Keying. To recognize the noise-digital modulation signals automatically, a new deep long short-term memory networks (LSTMs) model has been proposed and then applied to these signals successfully. A significant advantage of the proposed system is that deep learning method has been trained and tested with raw digital modulation signals without applying any feature extraction from the signals. In this study, the noise modulation signals of 5–25 dB have been classified and compared with each other. The innovative aspect of the study is to classify the modulation with the LSTM method without dealing with the extraction of signal characteristics. Without noise, added digital modulation signals had been classified as the success rate of 97.22%, while with all noise-added signals have been classified as the success rate of 94.72% with deep LSTM model. The experimental results show that the proposed deep LSTM model has been achieved remarkable results in recognition of noised six different modulation signals with a fully end-to-end structure.
AtıfScopus35WoS26OpenAlex35İncele - MakaleYalnız künye2019Scopus SJRQ1Combined boron, radiogenic (Nd, Pb, Sr), stable (C, O) isotopic and geochemical investigations of carbonatites from the Blue River Region, British Columbia (Canada): Implications for mantle sources and recycling of crustal carbon
Çimen, Okay; Kuebler, Corinne; Simonetti, Stefanie S.; Corcoran, Loretta; Mitchell, Roger; Simonetti, Antonio
This study reports the combined major, minor and trace element compositions, and stable (C, O), radiogenic (Nd, Pb, and Sr) isotopic compositions, and first δ11B isotopic data for the Fir, Felix, Gum, and Howard Creek carbonatites from the Blue River Region, British Columbia (Canada). These sill-like occurrences were intruded into Late Proterozoic strata during rifting and extensional episodes during the Late Cambrian and Devonian -Mississippian, and subsequently deformed and metamorphosed to amphibolite grade in relation to a collisional-type tectonic environment. The carbonatites at Fir, Gum, and Felix contain both calcite and dolomite, whereas the carbonatite at Howard Creek contains only calcite. The dolomite compositions reported here are consistent with those experimentally determined by direct partial melting of metasomatized peridotitic mantle. The combined major and trace element compositions and δ13CPDB (−5.37 to −4.85‰) and δ18OSMOW (9.14 to 9.62‰) values for all the samples investigated are consistent with those for primary igneous carbonate and support their mantle origin. However, these signatures cannot be attributed to closed system melt differentiation from a single parental melt. The initial Nd, Pb, and Sr isotopic ratios are highly variable and suggest generation from multiple, small degree parental melts derived from a heterogeneous mantle source. The δ11B values for carbonates from Felix, Gum, and Howard Creek vary between −8.67 and −6.36‰, and overlap the range for asthenospheric mantle (−7.1 ± 0.9‰), whereas two samples from Fir yield heavier values of −3.98 and −2.47‰. The latter indicate the presence of recycled crustal carbon in their mantle source region, which is consistent with those for young (<300 Ma) carbonatites worldwide. The radiogenic and B isotope results for the Blue River carbonatites are compared to those from contrasting, anorogenic tectonic settings at Chipman Lake, Fen, and Jacupiranga, and indicate that similar upper mantle sources are being tapped for carbonatite melt generation. The pristine, mantle-like δ11B values reported here for the Blue River carbonatites clearly demonstrate that this isotope system is robust and was not perturbed by post-solidification tectono-metamorphic events. This observation indicates that B isotope signatures are a valuable tool for deciphering the nature of the upper mantle sources for carbonates of igneous origin.
AtıfScopus28OpenAlex25İncele - MakaleAçık Erişim2019Scopus SJRQ2Improvement of sperm motility of Oncorhynchus mykiss and Salvelinus fontinalis by L-tryptophan
Kocabaş, Mehmet; Kutluyer, Filiz; Ertekin, Özlem; Aksu, Önder; Başçınar, Nadir
Experiments were designed to test the influence of L-tryptophan supplementation of the extender on the sperm motility parameters and bacterial flora of brook trout (Salvelinus fontinalis) and rainbow trout (Oncorhynchus mykiss). The extender containing 0.3 M glucose in 10% Dimethyl sulfoxide (DMSO) was supplemented with 0, 0.5, 1, 2, and 4 mM L-tryptophan. Sperm samples stored for up to 12 days at 4°C for brook trout were motile while motility was not observed after six days of storage for rainbow trout. Diluted sperm samples were spread-plated onto Plate Count Agar (PCA) (Total Bacteria Count), Rose Bengal Agar (RBC) (Yeast-Mold Count), Violet Red Bile Dextrose (VRBD) (Enterobacteriaceae count) and Mannitol Salt Agar (MSA) (Micrococcus/Staphylococcus count) and counts were performed in duplicate and sampling occurred on day 0, 2, 4, 6, and 12 of cold storage. L-tryptophan supplementation of the extender yielded a positive effect, significantly prolonging sperm motility in S. fontinalis and O. mykiss compared to the control group (p < 0.05). The ideal results were obtained above a concentration of 0.5 mM for both species. Total bacteria count in fresh sperm (undiluted samples) was not detectable and not detected in sperm samples treated with different L-tryptophan concentrations. Yeast-mold, Enterobacteriaceae and Micrococcus/Staphylococcus were not detected from fresh and treated sperm brook trout and rainbow trout. On the basis of the results, L-tryptophan-based extender is useful for maintaining sperm quality in short-term storage. L-tryptophan had a negative effect on the bacterial flora. The results of the current study encourages further studies related to long-term storage and reproduction management. Abbreviations: DMSO: dimethyl sulfoxide; PCA: plate count agar; RBC: rose Bengal agar; VRBD: violet red bile dextrose; MSA: mannitol salt agar; SCA: sperm class analyzer; CFU: colony-forming unit.
AtıfScopus13WoS14OpenAlex13İncele - MakaleYalnız künye2019Scopus SJRQ2Influence of RE oxides (Eu3+, Sm3+, Nd3+) on gamma radiation shielding properties of lead fluoroborate glasses
Wagh, Akshatha; Sayyed, M.I.; Askin, A.; Özpolat, Özgür Fırat; Sakar, E.; Lakshminarayana, G.; Kamath, Sudha D.
Authors report the change in lead fluoroborate glass properties with change in RE2O3 (RE = Eu, Sm, Nd) chemical composition. The RE2O3 exhibited improvement in the radiation shielding properties of the glass samples. The gamma rays shielding capabilities of the samples were studied using the WinXcom software (for Eu2O3, Sm2O3 doped glasses) and Monte Carlo simulation (for Nd2O3 doped glasses). The results exhibited that the mass attenuation coefficient (μm), effective atomic number (Zeff), and half value layer (HVL) depends on the concentration of RE2O3 and addition of the same significantly increased the shielding capabilities of the glass samples against gamma rays. The increase in photon energy revealed the decrease in radiation shielding properties. The reported density and radiation attenuation properties of RE2O3 doped lead fluoroborate glasses are predominant in radiation shielding applications which will be useful in high strength structures. Of all the glass samples 2.5 mol% of Eu2O3, Sm2O3 and Nd2O3 doped glasses showed enhanced shielding properties.
AtıfScopus40OpenAlex41İncele - MakaleYalnız künye2019Scopus SJRQ1A new approach for arrhythmia classification using deep coded features and LSTM networks
Yildirim, Ozal; Baloglu, Ulas Baran; Tan, Ru-San; Ciaccio, Edward J.; Acharya, U. Rajendra
Background and objective: For diagnosis of arrhythmic heart problems, electrocardiogram (ECG)signals should be recorded and monitored. The long-term signal records obtained are analyzed by expert cardiologists. Devices such as the Holter monitor have limited hardware capabilities. For improved diagnostic capacity, it would be helpful to detect arrhythmic signals automatically. In this study, a novel approach is presented as a candidate solution for these issues. Methods: A convolutional auto-encoder (CAE)based nonlinear compression structure is implemented to reduce the signal size of arrhythmic beats. Long-short term memory (LSTM)classifiers are employed to automatically recognize arrhythmias using ECG features, which are deeply coded with the CAE network. Results: Based upon the coded ECG signals, both storage requirement and classification time were considerably reduced. In experimental studies conducted with the MIT-BIH arrhythmia database, ECG signals were compressed by an average 0.70% percentage root mean square difference (PRD)rate, and an accuracy of over 99.0% was observed. Conclusions: One of the significant contributions of this study is that the proposed approach can significantly reduce time duration when using LSTM networks for data analysis. Thus, a novel and effective approach was proposed for both ECG signal compression, and their high-performance automatic recognition, with very low computational cost.
AtıfScopus377OpenAlex388İncele - MakaleAçık Erişim2019Scopus SJRQ4Paenidigyamycin g: 1-acetyl-2,4-dimethyl-3-phenethyl-1H-imidazol-3-ium
Tetevi, Gilbert Mawuli; Kwain, Samuel; Mensah, Thomas; Camas, Anil Sazak; Camas, Mustafa; Dofuor, Aboagye Kwarteng; Azerigyik, Faustus Akankperiwen; Oluwabusola, Emmanuel; Deng, Hai; Jaspars, Marcel
The Ghanaian Paenibacillus sp. DE2SH (GenBank Accession Number: MH091697) is a prolific producer of potent antiparasitic alkaloids. Further detailed study of the culture broth of this strain produced the compound Paenidigyamycin G (1), which is a derivative of the known antiparasitic compound Paenidigyamycin A (2). Compound (1) was isolated on HPLC at tR ≈ 37.5 min and its structure determined by IR, UV, MS, 1D, and 2D-NMR data. Compound 1 produced weak to moderate antileishmanial and antitrypanosomal activity when tested against Leishmania donovani (Laveran and Mesnil) Ross (D10) and Trypanosoma brucei subsp. brucei strain GUTat 3.1 with IC50 = 115.41 and 28.75 µM, respectively. This result is interesting since the parent compound 2 is known to possess consistent and potent antiparasitic activity. However, 1 displayed a promising selectivity profile towards T. brucei subsp. brucei due to its relatively low toxicity against normal mouse macrophages RAW 264.7 cells (SI = 8.70). Given that compound 1 is also the main metabolite found in the hexane fraction of all extracts produced by Paenibacillus sp. DE2SH when it is co-cultured with other bacteria strains, it must possess some unique biological functions which should make it an excellent candidate for further biological activity screening in other bioassays.
AtıfScopus4WoS3OpenAlex4İncele - Derleme MakaleAçık Erişim2019Scopus SJRQ2Evaluation of X-ray tomography contrast agents: A review of production, protocols, and biological applications
Koç, Mümin Mehmet; Aslan, Naim; Kao, Alexander P.; Barber, Asa H.
X-ray computed tomography is a strong tool that finds many applications both in medical applications and in the investigation of biological and nonbiological samples. In the clinics, X-ray tomography is widely used for diagnostic purposes whose three-dimensional imaging in high resolution helps physicians to obtain detailed image of investigated regions. Researchers in biological sciences and engineering use X-ray tomography because it is a nondestructive method to assess the structure of their samples. In both medical and biological applications, visualization of soft tissues and structures requires special treatment, in which special contrast agents are used. In this detailed report, molecule-based and nanoparticle-based contrast agents used in biological applications to enhance the image quality were compiled and reported. Special contrast agent applications and protocols to enhance the contrast for the biological applications and works to develop nanoparticle contrast agents to enhance the contrast for targeted drug delivery and general imaging applications were also assessed and listed.
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