Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Gul, Muhammet(82)
- Akkurt, Nevzat(67)
- Güler, Ömer(66)
- Baskonus, Haci Mehmet(62)
- Bulut, Hasan(60)
- Tekin, H.O.(52)
- ALMisned, Ghada(49)
- Yucesan, Melih(43)
- Yildirim, Numan(42)
- Yildirim, Nuran Cikcikoglu(38)
- Paksoy, Mehmet Yavuz(36)
- Serdar, Osman(36)
- Zengin, Gokhan(36)
- Ince, Muharrem(34)
- Celik, Erkan(33)
- Benzer, Fulya(32)
- Kocabaş, Mehmet(30)
- Sulaiman, Tukur Abdulkadir(30)
- Tanyol, Mehtap(29)
- Yildirim, Ozal(28)
- Aslan, Naim(26)
- Kök, Mediha(26)
- Özkul, İskender(26)
- Ates, Mehmet(25)
- Danabas, Durali(25)
- Kutluyer, Filiz(25)
- Can, Erkan(24)
- Kutlu, Banu(23)
- Onat, Onur(23)
- Demir, Veysel(22)
- Erten, Fusun(22)
- Guler, Omer(22)
- Say, Yakup(22)
- Güler, Seval Hale(21)
- Yaman, Mehmet(21)
- Baykal, Duygu Sen(20)
- Sançar, Taylan(20)
- Susam, Selim Orhun(20)
- Cakilcioglu, Ugur(19)
- Orhan, Cemal(19)
Yayınlar
- MakaleAçık Erişim2019Scopus SJRQ3Study of the bioaccumulation of UO2 2+ onto the green microalgae botryococcus braunii using response surface methodology
Celik, Fatih; Aslani, Mahmoud Ali Asker; Can, Safak Seyhaneyildiz
The bioaccumulation of UO2 2+ (uranyl ion) was investigated by using dry biomass of Botryococcus braunii. Experiments were conducted based on a rotatable central composite design (CCD) and analyzed using response surface methodology (RSM), which was used to optimize the bioaccumulation process. In this goal, the effects of parameters such as initial uranium (VI) concentration, pH, temperature and contact time were studied. The optimum conditions for maximum removal (87%) of UO2 2+ from an aqueous solution were as follows: initial uranium (VI) concentration (55 mg/l), pH (3.6), temperature (46°C) and contact time (74 min). Langmuir and Freundlich isotherms and also thermodynamic parameters like Enthalpy (∆H°), Entropy (∆S°), standard Gibbs free energy (∆G°) were investigated, as well.
AtıfScopus18WoS17OpenAlex8
İncele - MakaleYalnız künye2019Scopus SJRQ2Polytropic Carnot heat engine
Askin, M.; Salti, M.; Aydogdu, O.
Recent astrophysical datasets have implied that the universe has entered a speedy expansion phase. The Polytropic gas model, which describes a unified formulation of dark contents (matter plus energy), is one of the most reasonable definitions of this mysterious phenomenon. This interesting formulation allows to simulate the dark contents in the cosmic form of the perfect fluid and gives an interesting point of view in the discussion of fundamental theories of physics. In the first step of our investigation, we discuss the thermal equation-of-state (EoS henceforth) and obtain the EoS and deceleration parameters as explicit functions of temperature. Subsequently, we obtain a relation for the thermal efficiency of the Carnot heat engine which depends on free parameters given in the cosmological Polytropic gas description and the limits of maximal and minimal temperatures imposed on the Carnot cycle.
AtıfScopus8WoS8OpenAlex9İncele - MakaleYalnız künye2019Scopus SJRQ2Comprehensive study on the structural, optical, physical and gamma photon shielding features of B2O3-Bi2O3-PbO-TiO2 glasses using WinXCOM and Geant4 code
Sayyed, M.I.; El-Mesady, I.A.; Abouhaswa, A.S.; Askin, A.; Rammah, Y.S.
Glass samples of titanium-lead bismuth borate with the composition of (60B2O3 – 20Bi2O3 – (20-x)PbO – xTiO2), where 0 ≤ x ≤ 10 wt% labeled as BBPT0.0 (x = 0) to BBPT10.0 (x = 10) were synthesized. The melt quenching technique was used in the preparation. The amorphous character and vibrational groups for all samples were confirmed through XRD and FTIR measurements, respectively. The optical band gap (Eopt), Urbach's energy (Eurbach), and the optical dispersion constants have been determined using UV–Vis spectra. Results reveal that the values of the optical band gap energy exhibit a decrease with the TiO2 concentration, in contrast with Urbach's energy which displays a linear increase from 0.43 to 0.64 eV. In addition, the values of single-oscillator energy (Eo) has the same behavior of the optical energy gap (Eopt), while the dispersion energy parameter (Ed) has an inversely behavior. Mass attenuation coefficients (μ/ρ) of the investigated glasses have been computed using the Geant4 simulation toolkit and WinXCOM database software. Geant4 model of a HPGe detector has been employed to perform the Monte Carlo simulations for the glass samples with five thicknesses from 1 to 3 cm at the gamma ray energies in the range of 356–2510 keV. The transmission fractions as a function of the thickness at 356 keV photon energy for all studied glasses has been performed. Half value layer (HVL) was derived from the μ/ρ values. Results showed the studied glasses have good shielding capability according to their mass attenuation coefficients, transmission fractions and HVL values.
AtıfScopus140WoS136OpenAlex144İncele - MakaleYalnız künye2019Scopus SJRQ3Anesthetic Efficiency of Three Medicinal Plant Oils for Aquatic Species: Coriander Coriandrum sativum, Linaloe Tree Bursera delpechiana, and Lavender Lavandula hybrida
Can, Erkan; Kızak, Volkan; Can, Şafak Seyhaneyıldız; Özçiçek, Esin
This study evaluated the potential of three essential oils (EOs) that were obtained from coriander Coriandrum sativum (CEO), linaloe tree Bursera delpechiana (BEO), and lavender Lavandula hybrida (LEO) as anesthetic agents. Convict Cichlids Amatitlania nigrofasciata (Günther 1867) were exposed to eight concentrations of anesthetic (50, 75, 100, 125, 150, 200, 250, and 300 μL/L). After exposure to the anesthetic, the fish were transferred to clean water to recover. All of the EOs produced an anesthetic effect after exposure to the compounds for 30 min at the minimal effective concentration (MEC), which was identified according to deep anesthesia (A5 < 3 min) and full recovery (R3 < 5 min) times. At 50 and 75 μL/L, the total loss of equilibrium was not observed for all tested EOs. The total loss of reflex was induced at a faster rate with higher concentrations of anesthetic in all groups. The recovery time generally increased as the concentration of the anesthetic increased. These findings suggest that CEO, BEO, and LEO are all novel potential anesthetics for aquaculture, and the optimal concentrations were identified as 150 μL/L (A5; 156 ± 1.7 s and R3; 165 ± 2.9 s), 125 μL/L (A5; 176 ± 3.5 s; R3; 125 ± 2.0 s), and 200 μL/L (A5; 20.1 ± 2.4 s and R3; 162 ± 3.4 s), respectively. When considering the active ingredients of EOs, this study also demonstrated that future studies should be focused on the major components such as linalyl acetate, 1.8-cineole, α-pinene, geraniol, and linalool. Their synergistic effects should be examined in herbal anesthetic treatments, since new commercial anesthetics will likely contain them.
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İncele - MakaleAçık Erişim2019Scopus SJRQ2Synthesis of poly(An-co-vp)/zeolite composite and its application for the removal of brilliant green by adsorption process: Kinetics, isotherms, and experimental design
Tanyol, Mehtap; Kavak, Nevroz; Torlut, Gülben
In this study, a poly(acrylonitrile-co-N-vinyl pyrrolidone)/zeolite (poly(AN-co-VP)/zeolite) composite was synthesized by in situ free radical polymerization (FRP). The structural properties of the composite were analyzed by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). The characterization results indicated that the composite had a homogeneous and 3-dimensional (3D) structure. The decomposition temperature and glass transition temperature (Tg ) were found as 410∘ C and 152∘ C, respectively. A poly(AN-co-VP)/zeolite composite was used to investigate the adsorption of brilliant green (BG) which is a water-soluble cationic dye. The kinetics, isotherms, and thermodynamics of adsorption were examined, and results showed that equilibrium data fitted the Langmuir isotherm model, and the adsorption kinetics of BG followed pseudo-second-order model. According to the thermodynamic properties, the adsorption process was endothermic and spontaneous. Response surface methodology (RSM), which was improved by the application of the quadratic model associated with the central composite design, was employed for the optimization of the study conditions such as adsorbent mass, time, and initial dye concentration. The RSM indicated that maximum BG removal (99.91%) was achieved at the adsorbent mass of 0.20 g/50 mL, an initial BG concentration of 40.20 mg/L, and a contact time of 121.60 minutes.
AtıfScopus24WoS19OpenAlex27İncele - MakaleAçık Erişim2019Scopus SJRQ3Anesthetic and sedative efficacy of peppermint (Mentha piperita) and lavender (Lavandula angustifolia) essential oils in blue dolphin cichlid (Cyrtocara moorii)
Can, Erkan; Sümer, Esma
The use of different essential oils (Eos), which are considered as a good alternative to synthetic materials, is increasing day by day in fish species. Nevertheless, studies on the anesthetic effect of peppermint Eo (Mentha piperita; MPEo) and lavender Eo (Lavandula angustifolia; LAEo) are scarce. In the present study, the effective concentrations of three anesthetic materials (MPEo, LAEo, and MS-222) were previously determined in the concentrations range of 100–400 ppm in Cyrtocara moorii juveniles (4.92 ± 1.03 g and 7.13 ± 1.22 cm) with the criteria of appropriate induction time (AIt) and ready recovery time (RRt) (Trial 1). Afterwards, four different groups were established at three different sedative concentrations (10, 20, and 30 ppm and a control group without anesthetic additive) for transporting (Trial 2). The study concluded that MPEo and LAEo can be used as anesthetic and sedative agents in tropical fish species safely. The use of 100 µL L–1 (183.5 s AIt and 227.8 s RRt) and 300 µL L–1 (109.2 s AIt and 420.0 s RRt) MPEo and LAEo, respectively, was sufficient for deep anesthesia, whereas concentrations in the range of 10 to 30 µL L–1 are recommended for fish transport.
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İncele - MakaleYalnız künye2019Scopus SJRQ2Investigation of selective leaching and kinetics of copper from malachite ore in aqueous perchloric acid solutions
Tanaydın, Mehmet Kayra; Demirkıran, Nizamettin
In this study, the leaching kinetics of malachite in perchloric acid solutions was investigated. The dissolution behaviors of copper, zinc, and iron in the ore matrix were determined at different acid concentrations and reaction temperatures. It was observed that the concentration of perchloric acid had a major effect on the dissolution of copper, zinc, and iron. It was determined that the effect of temperature on the dissolution of these species was not as significant as concentration impact. The results obtained shown that copper in the ore matrix was completely leached while zinc and iron were partially dissolved in perchloric acid solutions. In addition, the effects of the acid concentration, reaction temperature, stirring speed, particle size, and solid-to-liquid ratio on the leaching of malachite were researched. In these experiments, it was observed that the leaching rate of copper increased with increasing solution concentration, stirring speed, and reaction temperature, and with decreasing solid-to-liquid ratio and particle size. A kinetic analysis was performed, and it was found that the rate of leaching reaction obeyed the mixed kinetic control model in the unsteady state. The activation energy of the leaching process was calculated to be 34.69 kJ/mol.
AtıfScopus19WoS16OpenAlex20İncele - MakaleYalnız künye2019Scopus SJRQ2Risk assessment for clearing and grading process of a natural gas pipeline project: An extended TOPSIS model with Pythagorean fuzzy sets for prioritizing hazards
Oz, Nurdan Ece; Mete, Suleyman; Serin, Faruk; Gul, Muhammet
A natural gas pipeline project is a broad construction system consisting of both offshore and onshore section, which aims to supply the natural gas to one country to another. In such these projects, main focus of the works should cover workplace, environment, health, and safety of workers and employers. To achieve this, a new occupational health and safety (OHS) risk assessment is necessary for reducing the negative effects of emerged risks. In this article, a fuzzy-based risk model is developed for prioritizing primary and residual risk. A two-dimensional (2D) risk matrix method is initially performed and the Pythagorean fuzzy technique for order preference by similarity to ideal solution (PFTOPSIS) method is then used to prioritize previously identified hazards. For the prioritization of primary and residual risks, hazards are assessed against two parameters (probability and severity) of 2D risk matrix. Unlike previous risk assessment studies, PFTOPSIS is applied for the first time. The fuzzy model is applied to a case study for clearing and grading process of a natural gas pipeline project. A sensitivity analysis is also performed on parameter weights in order to validate the model.
AtıfScopus93WoS80OpenAlex97İncele - MakaleYalnız künye2019Scopus SJRQ1A decision-support system based on Pythagorean fuzzy VIKOR for occupational risk assessment of a natural gas pipeline construction
Mete, Suleyman; Serin, Faruk; Oz, Nurdan Ece; Gul, Muhammet
Natural gas pipeline construction projects are major projects between countries that include onshore and offshore sections. Aim of these projects is to supply the natural gas from one place to another. Safety of workplace, environment and employers is also another important argument. In this respect, it is essential to conduct an occupational risk assessment (ORA) study to eliminate the risks that may arise around the pipeline. Application of multi-criteria decision analysis (MCDA) methods for the ORA has shown great increase recently. Also, developing a decision support system (DSS) which is easy to use and capable of extracting results enables decision makers to assess health and safety risks. Therefore, (i) A DSS based on Pythagorean fuzzy VIKOR (PFVIKOR) in ORA literature is developed for the first time; (ii) A case study is employed to risk assessment for trenchless crossings installation by auger boring process of the pipeline project; (iii) A sensitivity analysis is performed in the results of PFVIKOR-based DSS; and (iv) Two additional risk parameters called sensitivity to PPE non-utilization and undetectability are considered in ORA process apart from the classical risk assessment parameters of severity and probability. Developing such a DSS and applying it for risk assessment in a natural gas pipeline construction will contribute stakeholders in the energy industry.
AtıfScopus89WoS67OpenAlex83İncele - MakaleYalnız künye2019Scopus SJRQ2Two remarkable moss species new to Turkey and South-west Asia
Batan, N.; Alataş, M.; Erata, H.; Özdemir, T.
Bryum blindii and Dicranella crispa are reported new to Turkey and South-west Asia following a recent bryological excursion to the Ardahan and Burdur regions of Turkey. Illustrations, geographic distribution and comparisons with morphologically similar taxa are given.
AtıfScopus5WoS5OpenAlex16İncele - MakaleYalnız künye2019Scopus SJRQ1Supply-driven rebalancing of disassembly lines: A novel mathematical model approach
Mete, Suleyman; Çil, Zeynel Abidin; Celik, Erkan; Ozceylan, Eren
In recent years, the interest of disassembly line has increased owing to the economic reasons and increase of environmental awareness. The balancing of the disassembly line is one of the factors affecting directly the performance of the process. Companies with a line used effectively can gain many advantages in terms of economic aspect and it facilitates competition the companies with others. Moreover, uncertainties end-of-life products characteristics and quantity of supply/demand causes reassigned of task and altering cycle time. Rebalancing of disassembly line is required in this situation. In this study, a novel mixed integer programming model is proposed. Firstly, disassembly line balance is created, and then according to the given new supply, tasks are reselected and reassigned to the workstations. A real case study is presented. The generated test problems are also analyzed using proposed mathematical model. Through the analysis of rebalancing the existing disassembly line, it has been identified that an existing balance might have been changed to accommodate changes in the desired output rate in order to cope up with the variation of the cycle time.
AtıfScopus31WoS27OpenAlex31İncele - MakaleYalnız künye2019Scopus SJRQ1Investigation ofthe gamma ray shielding parameters of (100-x)[0.5Li2O–0.1B2O3–0.4P2O5]-xTeO2 glasses using Geant4 and FLUKA codes
Aşkın, A.; Sayyed, M.I.; Sharma, Amandeep; Dal, M.; El-Mallawany, R.; Kaçal, M.R.
In the present work, the radiation shielding proeprties of lithium borophosphtellurite glass system with the composition of (100-x) [0.5Li2O-0.1B2O3–0.4P2O5]-xTeO2 (x = 0, 10, 20, 30 and 40 mol%) were reported. The mass attenuation coefficient (μ/ρ) of the selected glass system (LiBPTe0, LiBPTe10, LiBPTe20, LiBPTe30 and LiBPTe40) was calculated at 356 keV, 662 keV, 1173 keV and 1330 keV photon energies by using Geant4 and FLUKA codes and the results were compared to the values obtained theoretically using WinXcom software. The correlation theory has been used to calculate the correlation coefficients (R2) between the results from WinXcom and the both simulations codes (Geant4 and FLUKA) for each sample. Moreover, some other radiation shielding parameters such as effective atomic number, photon transmission, mean free path and half value layer were calculated. The gamma photon transmission results showed that the transmission values of the 356 keV photons are lower than those of energies 662, 1173 and 1330 keV. At 356 keV, the transmission value for LiBPTe0 (at 6 cm thickness) is found to be 0.245 while at the same energy and thickness the transmission value is 0.088 for LiBPTe40. Out of all the glasses considered in present work, LiBPTe40 possesses the highest values of effective atomic number (Zeff). The Zeff values for the present glasses are 8.02, 9.55, 11.16, 12.85 and 14.64 for LiBPTe0, LiBPTe10, LiBPTe20, LiBPTe30 and LiBPTe40 respectively at 356 keV. The mass attenuation coefficient and effetive atomic number results showed that utilization 40% mol of TeO2 significantly improves the gamma ray shielding properties of the selected glass system. The shielding effectiveness of the selected samples was compared with other reference materials namely two radiation shielding glasses and four concretes used in different shielding purposes in terms of the mean free path (MFP) at 356 keV. The results revealed that the MFP of RS-253-G18 is lower than LiBPTe0sample. Moreover, the MFP of ordinary concrete is higher than the MFP of all glasses under examination, thus the investigated tellurite glasses have better attenuation features than the ordinary concrete.
AtıfScopus106OpenAlex107İncele - MakaleAçık Erişim2019Scopus SJRQ2Frictionless Contact Problem for a Functionally Graded Layer Loaded Through Two Rigid Punches Using Finite Element Method
Polat, A.; Kaya, Y.; Bendine, K.; Özşahin, T.Ş.
In this study, continuous contact problem in the functionally graded (FG) layer loaded with two rigid flat blocks resting on the elastic semi-infinite plane was analyzed by the finite element method. The two-dimensional numerical model of the FG layer was made with the software added to the ANSYS program. This software can be adapted to all contact problem types by making minor changes. The accuracy check of the program was performed by comparing with the analytical solution of the problem by homogeneous layer and its solution by the finite element method. So, fast and practical solutions can be obtained by the developed finite element method on many applications such as; automotive, aviation and space industry applications. The comparisons made showed that the proposed solution gave good results at acceptable levels. In the problem, it was thought that all surfaces were frictionless. The external loads P and Q were transmitted to the FG layer via two flat rigid blocks. Normal stresses between the FG layer and the elastic plane, initial separation loads, initial separation distances and contact stresses under the blocks were investigated for various dimensionless quantities.
AtıfScopus14WoS14OpenAlex11İncele - MakaleYalnız künye2019Scopus SJRQ2Regulation of signaling pathways by β-elemene in cancer progression and metastasis
Qureshi, Muhammad Z.; Attar, Rukset; Romero, Mirna A.; Sabitaliyevich, Uteuliyev Y.; Nurmurzayevich, Sadykov B.; Ozturk, Ozlem; Wakim, Lara H.; Lin, Xiukun; Ozbey, Ulku; Yelekenova, Armida Bakhytbekovna
Entry of β-elemene into various phases of clinical trials advocates its significance as a premium candidate likely to gain access to mainstream medicine. Based on the insights gleaned from decades of research, it seems increasingly transparent that β-elemene has shown significant ability to modulate multiple cell signaling pathways in different cancers. We partition this multicomponent review into how β-elemene strategically modulates various signal transduction cascades. We have individually summarized regulation of tumor necrosis factor related apoptosis-inducing ligand, signal transducers and activators of transcription, transforming growth factor/SMAD, NOTCH, and mammalian target of rapamycin pathways by β-elemene. Last, we will discuss the results of clinical trials of β-elemene and how effectively we can use these findings to stratify patients who can benefit most from β-elemene.
AtıfScopus33OpenAlex33İncele - MakaleYalnız künye2019Scopus SJRQ2Pollen morphology of three Chrysophthalmum schultz bip. (Asteraceae) species in Turkey
Karlıoǧlu Kılıç, Nurgül; Paksoy, Mehmet Yavuz; Özdemir, Emrah
The pollen morphology of three species of the genus Chrysophthalmum Schultz Bip. (Asteraceae) found in Turkey were studied with light microscope (LM) and scanning electron microscope (SEM). The three species were C. dichotomum Boiss. & Heldr., C. gueneri Aytac & Anderb., and C. montanum (DC.) Boiss. Pollen grains of the Chrysophthalmum species were identified as spheroidal and their apertures were shown to be tricolporate. The polar and equatorial axes, distance between colpus apices, length/width of colpus, length/width of porus, exine thickness, and length/base of spine were measured on the pollen grains. Pollen ornamentation of the three species was identified as echinate in LM and echinate-microperforate in SEM. These studied species were distinguished from each other using Kruskal–Wallis and Dunn’s test. The results indicate that pollen characteristics could be useful for distinguishing the examined species.
AtıfWoS1OpenAlex1İncele - MakaleYalnız künye2019Scopus SJRQ2Gammarus pulex as a Model Organism to Assess the Residual Toxicity of Slaughterhouse Wastewater Treated by Electrocoagulation Process
Yildirim, Nuran Cikcikoglu; Tanyol, Mehtap; Serdar, Osman; Yildirim, Numan
It was assessed the efficiency of the electrocoagulation (EC) in slaughterhouse wastewater (SW) treatment by using antioxidant parameters of Gammarus pulex. The SW was treated by EC. Superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities and malondialdehyde (MDA) levels in G. pulex exposed to pre- and post-treated of the SW during 24 h and 96 h were analysed. Standard methods were applied during the analysing process of the physicochemical quality parameters for both untreated and treated SW. All measured physicochemical parameters were decreased following the treatment process via EC. After the treatment process, it was observed that while SOD activities and MDA levels were decreased, CAT activities were increased and GPx activities did not exhibit any change. In conclusion, the present study demonstrated the abilities of untreated SW to promote oxidative stress in model organism. The SOD, CAT activities and MDA levels in G. pulex revealed that EC process were efficient in the SW treatment.
AtıfScopus10WoS9OpenAlex13İncele - Derleme MakaleAçık Erişim2019Scopus SJRQ2A new direction in social network analysis: Online social network analysis problems and applications
Can, Umit; Alatas, B.
The use of online social networks has made significant progress in recent years as the use of the Internet has become widespread worldwide as the technological infrastructure and the use of technological products evolve. It has become more suitable to reach online social networking sites such as Facebook, Twitter, Instagram and LinkedIn via the internet and web 3.0 technologies. Thus, people have shared their views on many different topics and their emotions with other users more widely on these platforms. This means that a huge amount of data is created on platforms where millions of people connect with each other through social networks. Nevertheless, the development of computational paradigms at high speed and complexity with technological possibilities allows analysis of valuable data by means of social network analysis methods. Our goal for this paper is to present a review of novel and popular online social network analysis problems with related applications and a reference work for researchers interested in analyzing online social network data and social network problems. Unlike other individual studies we have gathered 21 online social network problems and defined them with related studies. Thus, this study is original by presenting an important source of research by explaining the problems of online social network and the studies performed in this area.
AtıfScopus172WoS113İncele - MakaleYalnız künye2019Scopus SJRQ1Assessment of hydraulic properties of technosols using Beerkan and multiple tension disc infiltration methods
Yilmaz, Deniz; Bouarafa, Sofia; Peyneau, Pierre-Emmanuel; Angulo-Jaramillo, Rafael; Lassabatere, Laurent
The increasing global urban sprawl requires large amounts of materials, putting huge pressure on numerous natural resources. In particular, vast quantities of soils are used to create infrastructures or green spaces associated with new developments. Alternative solutions aimed at alleviating soil consumption are thus being encouraged. Creating urban soils by recycling waste from industrial and construction activities is feasible, but apart from their support function the resulting technosols should also be able to provide some ecosystem services such as the capacity to infiltrate water and filter contaminants. Various methods are routinely used for in situ characterization of the hydraulic behaviour of natural soils, but their ability to assess the hydraulic properties of technosols remains unclear. Indeed, technosols formed from recycled waste differ markedly from natural soil because they often contain a considerable proportion of coarse artefacts that affect their structure. In this study, results obtained by two distinct methods (ponding and tension infiltrometry), associated with two data processing methods (Beerkan estimation soil transfer (BEST) and numerical inversion), on a set of infiltration data measured on experimental plots made of technosols have been compared with each other. Both methods provided similar results and thus proved to be reliable when applied to technosols. Highlights: Reuse of by-products from anthropogenic activities is crucial to alleviate the consumption of natural soil. Hydraulic properties of technosols must be monitored to assess some of the ecosystem services they can provide. BEST and numerical inversion of multiple tension disc infiltration data gave consistent results. Reliability of the hydraulic characterization methods used for technosols deserves further inquiry.
AtıfScopus10WoS10OpenAlex12İncele - MakaleYalnız künye2019Scopus SJRQ2Apigenin as an effective anticancer natural product: Spotlight on TRAIL, WNT/β-catenin, JAK-STAT pathways, and microRNAs
Ozbey, Ulku; Attar, Rukset; Romero, Mirna Azalea; Alhewairini, Saleh S; Afshar, Behnaz; Uteuliev, Yerzhan Sabitaliyevich; Hanna-Wakim, Lara; Ozcelik, Beraat; Farooqi, Ammad Ahmad
Wealth of information gleaned from decades of high-impact research work; scientists have disentangled the complicated web of versatile regulators that underlie cancer development and progression. Use of structural biology approaches and functional genomics have helped us to gain new insights into complex nature of cancer, and it is now clear that genetic/epigenetic mutations, overexpression of oncogenes, inactivation of tumor suppressors, loss of apoptosis, and versatility of protein binding partners have contributory roles in carcinogenesis and metastatic spread. It is becoming progressively more understandable that reprogramming of gene expression during and nontranscriptional changes during cancer development and progression are initiated and controlled by deregulated signal transduction cascades, all of which collectively create an incalculable complexity. Data obtained through preclinical and clinical trials revealed that alterations in the targeted oncogenes and other downstream, and parallel pathways played a central role in the development of resistance against different therapeutics. Phytochemicals have regained limelight, and different natural products are currently being tested for efficacy in preclinical studies. Apigenin, a plant-derived flavonoid has considerable pharmacological value and is reportedly involved in the regulation of different signaling cascades. In this review, we have attempted to summarize rapidly evolving understanding of molecular biologists and pharmacologists about the potential of apigenin in the regulation of deregulated signaling pathways in different cancers. We have emphasized on the regulation of WNT/β-catenin and janus kinase/signal transducers and activators of transcription (JAK-STAT) pathways. We also comprehensively discuss how apigenin restored apoptosis in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant cancers. The review also gives a snapshot of microRNAs (miRNAs) that regulate wide-ranging biological processes, and it is now clear that each miRNA can control hundreds of gene targets. Apigenin was noted to upregulate miR-520b and miR-101 in different cancers to inhibit tumor growth. Moreover, apigenin-induced apoptotic rate was significantly higher when used in combination with miR-423-5p inhibitors or miR-138 mimics. Better comprehension of linear and integrated signaling pathways will be helpful in effective therapeutic targeting of deregulated signaling pathways to inhibit/prevent cancer.
AtıfScopus65OpenAlex66İncele - MakaleYalnız künye2019Scopus SJRQ2Experimental investigation of transverse loading on composite panels coated with different gelcoat colors subjected to UV radiation and hygrothermal aging
Dogan, Akar; Arman, Yusuf; Ozdemir, Okan
This study focuses on the effects of hygrothermal and UV radiation aging on the reinforced epoxy composites coated with gelcoat. The aim of this study is to investigate the influence of gelcoat colors on the tensile properties, impact behavior and thermodynamic properties of the composite panels after the aging process has been performed. Two different gelcoat colors were chosen as black and yellow. Unidirectional E-glass fiber fabrics with an areal density 300 g m-2 as reinforcement and epoxy matrix were used. Vacuum-assisted resin infusion molding (VARIM) method was used to manufacture composite panels. The tensile test specimens were prepared according to ASTM standards. Tensile strength of both fiber and transverse directions, the impact perforation threshold, and stroge modulus of the aged samples decreased compared to unaged (virgin) samples. However, the drop in mentioned properties for coated materials is less than for uncoated materials, especially in yellow coated materials. The temperature of hygrothermal conditions significantly affected the perforation threshold. Moreover, the tensile strength in transverse direction in yellow samples decreased approximately 13%, while it decreased 23% in the black coated samples. Impact perforation threshold of unaged (virgin), uncoated, coated with yellow gelcoat and coated with black gelcoat is obtained to be 75, 57, 65 and 61 J, respectively.
AtıfScopus12WoS9OpenAlex11İncele