Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Aydin, Ali(3)
- Ak, Tuba Parlak(2)
- Başak, Neşe(2)
- Demir, Veysel(2)
- Ince, Muharrem(2)
- Parlak Ak, Tuba(2)
- Serdar, Osman(2)
- Seven, Ismail(2)
- Yaman, Mine(2)
- Akkoyun, H. Turan(1)
- Aslan, Naim(1)
- Aydın, Ayşe Nur(1)
- Aydın, Sevinç(1)
- Baykalir, Burcu Gül(1)
- Bayramoglu Akkoyun, Mahire(1)
- Başçınar, Nadir(1)
- Bengu, Aydın Ş.(1)
- Benzer, F.(1)
- Bin-Shafique, Sazzad(1)
- Cakir, Y.(1)
- Celik, F.(1)
- Ceylan, Yusuf(1)
- DEMIRKIRAN, Nizamettin(1)
- Danabas, D.(1)
- Demir, V.(1)
- Dere, T.(1)
- Derman, Taner(1)
- Derviş, Sibel(1)
- Ekin, Suat(1)
- Ergin, S.(1)
- Erust, Ceren(1)
- Gul, Burcu(1)
- Gur, Seyfettin(1)
- Gül Baykalir, Burcu(1)
- Güler, Ömer(1)
- Güllüoglu, Hakan(1)
- Harlioğlu, Ayşe G.(1)
- Kaplan Ince, Olcay(1)
- Kaplan, O.(1)
- Kaplan, Olcay(1)
Yayınlar
- MakaleYalnız künye2026Scopus SJRQ3Green revolution in nanotechnology: phytogenic CuO nanoparticles for biomedical and pharmaceutical applications
Ceylan, Yusuf; Korkmaz, Nesrin; Kaçan, Fatma N.; Aydin, Ali; Korkmaz, Şengül A.; Yildirim, Ebru Ş.
Copper oxide nanoparticles (CuO NPs) were synthesized using a green approach with Vitis vinifera L. extract, a plant rich in secondary metabolites that act as natural reducing agents. The obtained CuO NPs were characterized by XRD, EDX, and STEM analyses. FT-IR analysis revealed the presence of functional groups originating from plant biomolecules and confirmed the formation of Cu–O bonds, indicating the successful synthesis and stabilization of CuO NPs. XRD confirmed distinctive CuO diffraction peaks at 32.38°, 35.35°, 38.61°, 40.75°, 48.79°, 51.90°, 57.66°, 61.38°, 65.94°, and 75.12°. STEM imaging showed predominantly spherical, well-dispersed nanoparticles with an average size of 23–38 nm. Antibacterial analysis revealed a minimum inhibitory concentration (MIC) of 4 µg mL−1 against Escherichia coli ATCC 25922. In anticancer assays, the CuO NPs demonstrated notable cytotoxicity at both low concentrations and even at levels below the control group in A549, Calu-1, and Saos-2 cancer cell lines, highlighting their strong biomedical potential.
AtıfScopus1WoS1OpenAlex1
İncele - MakaleAçık Erişim2026Scopus SJRQ4Solvent Extraction of Copper from Sulfate Solutions Using Acorga OPT5510; [Extracción de cobre de soluciones de sulfato mediante solventes con Acorga OPT5510]
Karacahan, Mehmet Kayra
This study used a solvent extraction technique with AcorgaOPT5510 extractant in kerosene to examine the extraction of copper ions from the actual leach solution produced after leaching malachite ore in sulfuric acid solutions. On the Cu/Fe separation factor and the effectiveness of copper extraction, the impacts of significant parameters, including stirring speed, contact duration, extractant concentration, beginning solution pH, and temperature, were examined. The following values were chosen as the optimal ones: 1:1, 1.5, 12%, 20 °C, 10 min, 10 min, and 500 rpm for maximum Cu2+ extraction from the aqueous-phase, aqueous/organic phase ratio, equilibrium pH of the aqueous phase, extractant concentration, temperature, contact time, settling time, and stirring speed. Under these conditions, 94% of the copper in the leach solution was removed, yielding about 40.09 Cu/Fe separation factor. A McCabe-Thiele plot was revealed, and it was shown that a two-step extraction procedure would yield the best results. Furthermore, employing a sulfuric acid concentration of 4 mol·L-1 for 10 minutes, the loaded organic phase was stripped and recovered 91% copper.
- MakaleYalnız künye2026Scopus SJRQ2Kinetic investigation on the recovery of copper and cobalt from sulphuric acid plant electrofilter dust
Erust, Ceren
Several waste dusts collecting equipment options are available for air pollution control in plants, the most commonly used being the electrofilter. Industrial wastes such as electrofilter dust are evaluated as a secondary resource owing to their critical metal contents. In this work, the results of studies on the extraction of cobalt and copper from electrofilter dust generated in sulphuric acid production plants are presented. The chemical and mineralogical compositions of the dust were investigated using instrumental analytical methods. The electrofilter dust consists of the main phases of haematite, quartz, and anhydrite. Also, electrofilter dust contains 1.43% copper and 0.28% cobalt. It was found that the process of copper and cobalt dissolution is characterized by chemical kinetics. When the acid leaching was applied in 1 M sulphuric acid in the presence of 0.05 M hydrogen peroxide, with the temperature 80°C and 2 h of leaching time, stirring rate of 200 rpm and liquid to solid ratio 20/1 v/w, cobalt and copper extraction achieved 88% and 98% respectively. As a result of studying the kinetics of acid leaching with sulphuric acid in the presence of oxidant hydrogen peroxide, activation energy and the type of reaction to chemical controlled model were determined.
AtıfScopus2WoS2OpenAlex1İncele - MakaleYayıncıda açık erişim2025Scopus SJRQ2Determination of Toxic Effects of Copper in Navicula cryptocephala var. veneta by Biomarkers and Bioaccumulation Quantification
Aydın, Ayşe Nur; Serdar, Osman; Ölçülü, Abdüllatif; Çimen, Işıl Canan Çiçek; Ak, Tuba Parlak; Derman, Taner; Sevim, Ayşegül; Yıldırım, Nuran Cikcikoğlu
As a result of the increased use of metals such as copper (Cu), copper pollution in the environment is also increasing. In order to investigate the effect of copper mixed into the water environment and on aquatic biota, the microalga Navicula cryptocephala var. veneta was chosen as a model organism. N. cryptocephala var. veneta it was aimed to determine the accumulation and elimination amounts and some biomarker responses. Metal accumulation amounts in the organisms used in the study. The amount of metal accumulated in relation to the wet weight mass of the samples was determined using Atomic Absorption Spectophotometry (AAS) mass spectrometry. In the bioassays conducted within the scope of the study, lipid peroxidation (TBARS) and reduced glutathione (GSH) levels, superoxide dismutase (SOD) enzyme activity, glutathione peroxidase (GSH-Px) enzyme activity and catalase (CAT) enzyme activity were determined with an ELISA microplate reader at 24, 48, 72, 96 and 120 hours. According to the study data, it was observed that Cu metal accumulated in Navicula cryptocephala var. veneta and caused oxidative stress in the organism, affecting the organism by causing changes in TBARS, GSH levels and antioxidant enzymes SOD, CAT and GPx activities. Additionally, it was observed that different elimination levels occurred in the application groups.
AtıfScopus1OpenAlex1
İncele - MakaleYalnız künye2025Scopus SJRQ4Bioaccumulation of copper by Gammarus pulex (L., 1758): monitoring through a statistical modelling approach
Pala, Aysegul; Ince, Muharrem; Serdar, Osman
The aim of this study is to test freshwater gammarids as ecotoxicological biomarkers. Gammarids were collected from fresh water and adapted to the laboratory environment. Then, the influence of various variables was investigated. For monitoring and detecting the bioaccumulation level in Gammarus pulex exposed to controlled copper ions and to evaluate potential human and ecological risks, the use of G. pulex as sentinel indicators of water quality is one rational approach. Copper bioaccumulation rate and fate are currently not sufficiently studied. For optimization, the experimental conditions to ensure bioaccumulation level and to find the effects of various variables on proses, a Box–Behnken experimental design was performed. Used mentioned model with statistical underpinnings for Cu2+ ions bioaccumulation have been analyzed, tested and verified and the viability of G. pulex as a biomonitor. The variables’ optimum levels (temperature; 18.1, pH; 4.3, initial concentration of Cu2+ ions, mg L−1; 11.2 and exposure time, h; 42.2) were achieved by employing the quadratic regression model. Critical role of G. pulex in freshwater biomonitoring and their potential to be evaluated as biomarkers for Cu2+ ions was confirmed. It was also explored to see if G. pulex may serve as a potential tool for estimating aquatic quality.
AtıfScopus1WoS1OpenAlex1İncele - MakaleYalnız künye2024Scopus SJRQ2Activity of nanosized copper-boron alloys against Phytophthora species
Yiğit, Uğur; Türkkan, Muharrem; İlhan, Hasan; Şimşek, Tuncay; Güler, Ömer; Derviş, Sibel
This study aimed to evaluate the antifungal activity of copper-boron (Cu-B) nanoalloys against a range of Phytophthora species, including P. capsici, P. citrophthora, P. palmivora, P. cinnamomi, P. nicotianae, P. cactorum, P. plurivora, P. inundata, and P. megasperma. The nanoalloys were synthesized via mechanical alloying under an argon atmosphere, resulting in the formation of nanocrystalline Cu-B nanoalloys with irregular morphology and particle sizes ranging from 50 to 240 nm. At a concentration of 250 µg mL−1, the Cu-B nanoalloys demonstrated complete inhibition of mycelial growth, sporangium production, and zoospore germination in all tested Phytophthora species. The EC50 values for mycelial growth ranged from 28.02 to 120.17 µg mL−1, while for sporangium production and zoospore germination, they were below 10 µg mL−1. Furthermore, the nanoalloys exhibited fungicidal activity against specific Phytophthora species, such as P. capsici, P. citrophthora, P. inundata, and P. megasperma, at concentrations of 100, 250, 250, and 250 µg mL−1, respectively. Notably, the Cu-B nanoalloys displayed significant protective and curative effects on tuber rot severity in P. nicotianae-inoculated potatoes, resulting in reductions of 94.13% and 92.61% compared to the control, respectively, at a concentration of 10 µg mL−1 (P < 0.05). These findings highlight the potential of Cu-B nanoalloys as a promising fungicide for the management of plant diseases caused by Phytophthora spp.
AtıfScopus3WoS1OpenAlex2İncele - MakaleAçık Erişim2023Scopus SJRQ2Surface Morphology, Structural, Photovoltaic and Optoelectronic Properties of Diamond Like Carbon-Copper Nanostructures
Kara, Salih; Aslan, Naim; Kurt, Mustafa Şükrü
In this work, we produced Cu doped diomond like carbon films using the magnetron sputtering technique and assessed their structural electrical and optoelectronic characteristics. In the atomic force microscopy (AFM) measurements, it was observed that the surface of the Cu-DLC nanocomposite films was in a granular form and the presence of cluster-like formations. D and G bands, which are the characteristic peaks of the DLC structure, were observed in the Raman spectrum, while Cu and C peaks were observed in the energy dispersive (EDX) spectrum. Photocurrent, photocapacitance, photosensitivity and photoresponse values increased depending on the increasing light intensity. However, the Cu-DLC/n-Si structure displayed low photovoltaic properties. The capacitance and conductance values were considerably affected by the increase in AC signal frequency. The series resistance and the density of the interface states exhibited low frequency dependent behavior which were obtained using the electrical characteristics of the nanocomposite films.
AtıfScopus7WoS7OpenAlex6İncele - MakaleAçık Erişim2022Scopus SJRQ2Chrysin and flunixin meglumine mitigate overloaded copper-induced testicular and spermatological damages via modulation of oxidative stress and apoptosis in rats
Parlak Ak, Tuba; Tatli Seven, Pinar; Gur, Seyfettin; Gul, Burcu; Yaman, Mine; Seven, Ismail
This study aimed to evaluate the possible protective actions of chrysin and flunixine meglumine on testicular and spermatological injuries experimentally stimulated by copper. We separated 36 male Sprague–Dawley rats into six equal groups: control, chrysin, flunixine meglumine, copper, copper +chrysin and copper +flunixine meglumine. Chrysin (50 mg/kg/bw/po), flunixine meglumine (2.2 mg/kg/bw/ip) and copper (500 mg/kg/bw/po) were administered day to day for 21 days. Copper administration caused significant morphological, physiological and biochemical alterations compared to the control group, which are as follows: production of oxidative stress, thanks to rise in testis lipid peroxidation and fall in antioxidant enzyme concentrations, decrease in sperm quality and increase in morphologic sperm abnormalities, suppression of spermatogenesis and prominent alterations in the testis histomorphology and induction of apoptosis in the testis tissues. On the other hand, compared to the copper group, treatment with chrysin or flunixine meglumine significantly attenuated these alterations. In conclusion, chrysin and flunixine meglumine have benefits such as antioxidant, antiapoptotic and anti-inflammatory against copper-induced testicular and spermatological damages in rats via the modulation of oxidative stress and apoptosis. Consequently, chrysin is a natural product which has comparable therapeutic actions to flunixine meglumine on the male reproductive system.
AtıfScopus4OpenAlex4
İncele - MakaleAçık Erişim2022Scopus SJRQ1Optimization of process parameters and kinetic modelling for leaching of copper from oxidized copper ore in nitric acid solutions
TANAYDIN, Mehmet Kayra; TANAYDIN, Zümra Bakıcı; DEMIRKIRAN, Nizamettin
The leaching behavior of Tunceli malachite mineral was investigated in nitric acid solutions by two steps to evaluate the effect of various experimental parameters. In the first step, the optimal conditions for the leaching process were determined, while in the second step, a kinetic evaluation for the process was performed. In the optimization experiments, the concentration of nitric acid, temperature, stirring speed, and solid-to-liquid ratio were selected as the independent variables, and the central composite design method (CCD) was applied to the experimental data. At the end of the experiments, the optimal values for the concentration of nitric acid, temperature, solid-to-liquid ratio and stirring speed were determined to be 0.5 mol/L, 50 °C, 0.004 g/mL and 500 r/min, respectively. Under the optimal conditions, the leaching rate was found to be 99% for 120 min of reaction time. In the kinetic evaluation tests, the effects of the concentration of nitric acid, temperature, stirring speed, solid-to-liquid ratio and particle size on the leaching rate of copper from malachite were investigated. In these tests, it was determined that the leaching rate increased with the increase in the temperature, acid concentration and stirring speed, and with the decrease in the particle size and solid-to-liquid ratio. In consequence of the kinetic analysis, it was observed that the leaching kinetics followed the mixed kinetic model, and a mathematical model for the leaching process was introduced. The activation energy for this process was calculated to be 36.23 kJ/mol.
AtıfScopus18WoS17OpenAlex17İncele - MakaleAçık Erişim2022Scopus SJRQ2Determination of trace element and fatty acid levels in tissues of mirror and scaly carp (Cyprinus carpio L., 1758) living in Keban Dam Reservoir (Elazig)
Aydın, Sevinç; Akkoyun, H. Turan; Bayramoglu Akkoyun, Mahire; Bengu, Aydın Ş.; Ekin, Suat; Harlioğlu, Ayşe G.
This study investigated the concentrations of some accumulated trace metals (iron, manganese, zinc and copper) and fatty acids in liver and muscle tissues of mirror and scaly carp varieties (Cyprinus carpio L., 1758) living in Keban Dam Reservoir (Elazig), which is the second-largest artificial lake in Turkey that hosts commercially valuable and preferred fish varieties for human consumption. The inductively coupled plasma mass spectrometry (ICP-MS) method was used to analyse the concentrations of trace elements. Fatty acid levels were measured in a gas chromatography mass spectrometry (GC–MS) device, using a flame ionization detector (FID). Considering the two fish varieties and tissues that were studied, the mean metal concentrations (μg g−1) were found in the following ranges: Fe 12.32–49.97, Mn 0.12–0.62, Zn 10.45–86.59 and Cu 2.74–11.86. Although the lowest levels were detected in the muscle tissue for all the metals examined, the levels in the liver tissue were significantly higher. According to the results of the analyses on fatty acid concentrations, the mean total saturated fatty acid levels in the muscle tissue of the scaly carp and mirror carp varieties were found to be 31.07 and 31.43 (%), respectively, whereas these values for the liver tissue were consecutively 22.36 and 22.08 (%). Successively, the mean total levels of unsaturated fatty acids were determined as 68.93 and 68.40 (%) in the muscle tissue and 77.64 and 77.92 in the liver tissue. This study, with the finding that the trace (metallic) element accumulation rates were below the upper limits of the tolerable range, and the examined fish varieties were rich in fatty acids, shows that mirror carp and scaly carp living in Keban Dam Reservoir are highly nutritious for human diets.
AtıfScopus1OpenAlex2İncele - MakaleAçık Erişim2021Scopus SJRQ2Exposure to copper and risk assessment for human health via consumption of alcoholic beverages
Ince, Muharrem; Kaplan Ince, Olcay; Onal, Ali
Present study was performed using a Box–Behnken Design (BBD) combined with a response surface methodology (RSM). The ultimate goal of this research was to apply BBD for modeling of copper (Cu2+) ions from alcoholic beverages and evaluate health risk assessment of Cu2+ via consumption of alcoholic beverages. The importance of independent paramaters and their interactions were examined using analysis of variance (ANOVA). Natural clay was investigated to remove Cu2+ ions from some alcoholic beverage samples including beer and wine. X-ray diffraction (XRD), fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) coupled with energy dispersive X-ray (EDS) analysis were used for adsorbent characterization. Same analyzes were applied for Cu2+ loaded clay. In addition, experimental studies showed that Freundlich isotherm was better than Langmuir isotherm. Finally, optimized method was applied to alcoholic beverages. Besides target hazard quotients (THQ), estimated daily intake (EDI) values were calculated, to assess a health risk resulting from these alcoholic beverages regular consumption. The EDI values of Cu (µg/day/person) through consumption of investigated drinks were less than the recommended dietary allowance values. Also, the THQ values of Cu2+ were less than 1. According to estimated target hazard, it can be said no long life health concerns of Cu2+ is associated with the consumption of studied drinks. Obtained results were compared with the data from literature and levels set by regulatory authorities, it can be clearly stated that the consumption of mentioned alcoholic beverages do not pose a toxicological risk.
AtıfScopus14WoS10OpenAlex11İncele - MakaleYalnız künye2020Scopus SJRQ4Spermatologic characteristics and sperm motility alterations caused by short-term copper exposure in Brook Trout Salvelinus fontinalis
Kutluyer, Filiz; Kocabaş, Mehmet; Başçınar, Nadir
Spermatozoa movement in many aquatic animals with external fertilization is directly related to the external aqueous environment. In particular, environmental toxic metals can cause harmful effects and impair sperm cell functions. The high concentrations of copper (Cu) may be harmful for aquatic animals, while low levels are required for metabolic interactions. Herein, we investigated the effect of different copper concentration [0 mg L−1 (Control),.5 mg L−1, 1 mg L–1, and 2 mg L−1] on spermatozoa of brook trout Salvelinus fontinalis. Motility and survival of sperm cells were assessed. Our results indicated that Cu exposure caused to an evident decrease in motility and longevity of spermatozoa with increasing concentrations (p <.05). Overall, we showed that Cu exposure can impair sperm motility of S. fontinalis. Our study suggested that sperm motility has the potential to be a sensitive bioindicator of freshwater environmental pollution.
AtıfScopus3WoS3OpenAlex3İncele - MakaleYayıncıda açık erişim2019Scopus SJRQ2Evaluation of pharmacological activity of heterobimetallic coordination compounds containing n, n-bis (2-hydroxyethyl)-ethylenediamine on ht29, hela, c6 and vero cells
Aydin, Ali; Korkmaz, Şengül Aslan
The present study was conducted in order to investigate the pharmacological activities of three heterobimetallic coordination compounds: [Cd(N-bishydeten)2 ][Ni(CN)4 ] (C1), [Cu2 (N-bishydeten)2 Co(CN)6 ].3H2 O (C2), and K[Cd(N-bishydeten)Co(CN)6 ].1.5H2 O (C3) (N-bishydeten = N,N-bis(2-hydroxyethyl)-ethylenediamine). This paper describes the ability of complexes to inhibit cell growth, cell migration and human topoisomerase I and to interact with DNA/BSA; this paper also evaluates the potential mechanisms of action exhibited by these compounds via the use of powerful measurement techniques. Studies on HT29, HeLa, C6 and Vero cells revealed that each compound demonstrated significant antiproliferative activity in conjunction with regressed cell migration velocity and caused apoptotic changes in morphology. There are strong data suggesting that the mechanisms of action exhibited by these compounds are associated with their DNA/BSA binding features. The IC50 and binding constant range for the compounds are 20-180 µM and 1.2-3.2 x 104 M-1, respectively. Moreover, we observed that these compounds alter the P53-Bcl-2 ratio and inhibit the relaxation activity of human topoisomerase I. Furthermore, a correlation between the antiproliferative effects of these compounds and their cytotoxic activity was observed. In conclusion, preliminary information demonstrates that these compounds have been found to exhibit effective antiproliferative activity against cancer cell lines, indicating that they are a potent candidate for further pharmacological study.
AtıfScopus5WoS5OpenAlex3İncele - MakaleAçık Erişim2018Scopus SJRQ3The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats; [Ratlarda bakır fazlalığına karşı yem tüketimi, antioksidan durum ve karaciğer ile böbrek dokularının histolojik parametreleri üzerine propolis ve fluniksin meglümin'in koruyucu etkileri]
Tatli Seven, Pınar; Gül Baykalir, Burcu; Parlak Ak, Tuba; Seven, İsmail; Başak, Neşe; Yaman, Mine
This experiment was conducted to determine the protective effects of flunixin meglumine and propolis on feed intake, antioxidant status and histological parameters in kidney and liver tissues in rats exposed to excessive copper. In this study individually housed thirty-six male Sprague-Dawley rats were used. Animals were randomly divided into six groups; control, copper sulphate (500 mg/kg BW/day, gavage), flunixin meglumine (2.2 mg/kg BW/day, ip), propolis (100 mg/kg BW/day, gavage), copper sulphate+flunixin meglumine (500 mg/kg BW/day of copper sulphate by gavage and 2.2 mg/kg BW/day of flunixin meglumine, ip) and copper sulphate+propolis (500 mg/kg BW/day of copper sulphate and 100 mg/kg BW/day of propolis by gavage). The study demonstrated that body weight change in the copper sulphate+propolis group significantly ameliorated in comparison with copper group (P<0.01). Propolis and flunixin meglumine administration significantly decreased MDA levels in the kidney and liver tissues, and serum TNF-α levels (P<0.001). Propolis supplementation to rats who were also treated with copper significantly increased the superoxide dismutase, catalase and reduced glutathione activities (P<0.001). Flunixin meglumine and propolis treatments decreased the copper-induced degenerative and necrotic changes with the apoptotic cells in the liver and kidney tissues. In conclusion, propolis appeared to ameliorate the adverse effects on feed intake, liver and kidney tissues seeing in the copper treatment and, apparently caused by the copper toxicity, by scavenging the free radicals and increasing activity of antioxidants.
AtıfScopus10OpenAlex9İncele - MakaleAçık Erişim2018Scopus SJRQ3The protective effects of chrysin and flunixin meglumine against excess copper in male rats
Seven, Pinar Tatli; Baykalir, Burcu Gül; Seven, Ismail; Ak, Tuba Parlak; Başak, Neşe; Güllüoglu, Hakan
Thirty-six Sprague Dawley male rats were housed in individual cages and randomly divided into six groups: Control, copper sulfate (Cu; 500 ppm body weight (BW)/day), flunixin meglumine (FM; 2.2 ppm BW/day), chrysin (chrysin; 50 ppm BW/day), copper sulfate + FM (Cu + FM; 500 ppm BW/day of copper sulfate and 2.2 ppm BW/day of FM), and copper sulfate + chrysin (Cu + Chrysin; 500 ppm BW/day of copper sulfate and 50 ppm BW/day of chrysin). Feed intake (FI) in the Cu + Chrysin group significantly increased in comparison with that of the Cu group (P < 0.01). Cu excess significantly increased malondialdehyde, indicating oxidative stress. Chrysin and FM administration significantly decreased malondialdehyde levels and increased the superoxide dismutase and catalase activities in the liver and kidney tissues (P < 0.001). Serum TNF-α levels were significantly lower in the Cu + FM and Cu + Chrysin groups in comparison to the Cu group (P < 0.001). It was seen that FM and chrysin treatments alleviated degeneration, necrosis, and apoptosis in the liver and kidney tissues of the Cu-treated rats. Chrysin appeared to ameliorate the adverse effects on FI and liver and kidney tissues by scavenging where the free radicals are located and increasing the activity of antioxidants.
AtıfScopus8WoS7OpenAlex9TR Dizin2İncele - MakaleYalnız künye2017Scopus SJRQ2Anticancer and Cytotoxic Activities of [Cu(C6H16N2O2)2][Ni(CN)4] and [Cu(C6H16N2O2) Pd(CN)4] Cyanidometallate Compounds on HT29, HeLa, C6 and Vero Cell Lines
Aydin, Ali; Korkmaz, Sengul Aslan; Demir, Veysel; Tekin, Saban
Background: In cancer, apoptosis relevant proteins-such as CaM kinase, Bcl-2 or P53, topoisomerase I, cell migration feature and DNA/BSA-macromolecules represent significant targets for current chemotherapeutics. Objective: We recently reported two coordination compounds-[Cu(C6H16N2O2)(2)][Ni(CN)(4)] (1) and [Cu(C6H16 N2O2) Pd(CN)(4)] (2)-together with their IR spectra, magnetic properties, thermal analyses and crystal structures. Herein, we describe the ability of these complexes to induce apoptosis in relevant proteins and stimulate topoisomerase I activity, cell migration velocity and DNA/BSA binding properties. Method: The in vitro antiproliferative effects and cell toxicity of both compounds were investigated through pharmacological measurement techniques, and interactions between both compounds and CT-DNA/BSA were studied with UV-Vis spectroscopy and fluorescence spectroscopy. Results & Conclusion: Studies on cells revealed that 2 (i) demonstrated a high antiproliferative effect, which was higher toward HeLa and C6 cancer cells than toward healthy Vero cells; (ii) impaired the migration of HeLa cells; (iii) altered the P53-Bcl-2 ratio in favor of apoptosis; (iv) strongly bound to DNA/BSA macromolecules; and (v) inhibited human topoisomerase I and KpnI or BamHI restriction endonucleases. In conclusion, this preliminary information demonstrates that 2 may represent a promising antiproliferative agent and a potential candidate for a therapeutic approach against HeLa.
AtıfWoS3OpenAlex4İncele - MakaleYalnız künye2015Scopus SJRQ3Determination and Health Risk Assessment of Heavy Metals in Drinking Water of Tunceli, Turkey
Demir, V.; Dere, T.; Ergin, S.; Cakir, Y.; Celik, F.
Tunceli, Turkey is one of the small cities in the Eastern Anatolian Region with substantial natural, cultural and historical heritage that is suitable to be a slow city. Water sources are abundant in the area due to rain and heavy snowfall in the mountains, which seeps into the ground or flows into the rivers. Therefore monitoring and conservation of city's drinking water quality is one of the main issues in the city. The present study was conducted to investigate several heavy metals and cyanide, arsenic, and selenium concentrations of drinking water samples taken from 100 different locations in the city and towns of Tunceli, Turkey during the years 2011 and 2012. In three locations, high levels of copper was found with a range of 2.1-11.5 mg/L, and high levels of arsenic was detected in five locations with a range of 10.5-78.0 mu g/L, exceeding the action levels for copper and arsenic. For health risk assessment, the average daily dose and hazard quotient (HQ) were calculated. The region mean values of HQ were found above 1 for arsenic in the samples collected from Mazgirt, while HQ values were below 1 in the rest of the samples.
AtıfWoS20OpenAlex33İncele - MakaleYalnız künye2013Scopus SJRQ3EFFECT OF THE PRESENCE OF PHOSPHATE BASED FERTILIZER ON METAL REMOVAL CAPACITY OF NATIVE BIORETENTION MATERIALS
Demir, Veysel; Bin-Shafique, Sazzad
Batch tests were conducted on several Texas native bioretention media to estimate the removal capacity of lead and copper from contaminated water and to understand the effect of the presence of phosphate (due to application of phosphate based fertilizers in the watershed) on metal removal. The results show that the 77% of lead and 58% of copper precipitated as the phosphate added to the contaminated water even before adding any media. Cedar mulch and hardwood mulch performed best and removed 99.2% of lead and 97.5% of copper from aqueous solution. When phosphate was added, removal increased to 97.8% for copper and 100% for lead (under detection limits). The removal capacity of metals was with the order of cedar mulch > hardwood mulch > pine mulch > sawdust > loam soil > silica sand. The leaching of metals from the media was much lower than the original solution and decreased when phosphate was added.
AtıfWoS2İncele - MakaleYalnız künye2011Scopus SJRQ3Levels of copper in liver, muscle and gill tissues in Capoeta trutta (Heckel, 1843) from Munzur River, Turkey
Danabas, D.; Benzer, F.; Kaplan, O.; Yildirim, N. C.
Heavy metal pollution of waters is a major environmental problem. Due to their toxicity, long persistence, bioaccumulative and nonbiodegradable properties in the food chain, heavy metals constitute a core group of aquatic pollutants. Capoeta trutta is an economically important fish and the object of significant commercial fishery in the Munzur River. Levels of Cu were measured in samples of the muscle, gill and liver tissues of C. trutta from Munzur River. In liver copper levels were higher at Station I (6.15 mg kg(-1)) polluted by domestic waste than Station II (5.48 mg kg(-1)) (P<0.05). The highest copper level (7.25 mg kg(-1)) was measured in muscle tissue at Station II. There was found no statically differences between stations in gill and muscle (P>0.05). It is suggested that ecological condition of freshwater fish and contamination levels in Munzur River must be regularly monitored.
AtıfWoS7İncele - MakaleAçık Erişim2011Scopus SJRQ2Sequential and Selective Extraction of Copper in Different Soil Phases and Plant Parts from Former Industrialized Area
Kaplan, Olcay; Kaya, Gokce; Yaman, Mehmet
Copper (Cu) is an essential trace element for all living organisms; however, excess amounts in soil, plants, and food have negative impacts on the environment and human health. The aim of this study was to determine Cu levels in different chemical phases of soils and the relationship between Cu levels in soil phases and concentrations in plants. Soils and plants grown in these soils from an industrialized area in Turkey were analyzed using a selective and four-stage sequential extraction procedure. Copper levels in exchangeable fractions were found up to 658 mg kg(-1) while total levels were in the range of 133-5609 mg kg(-1). Copper concentrations in plant parts (roots and stem) were in the range of 2.6-240 mg kg(-1). The exchangeable forms of Cu were in the range of 3-22% of total Cu concentrations. The relationships were observed between soil Cu and Rumex plant Cu, and soil Cu and root of Brassicasea plant Cu.
AtıfWoS11OpenAlex10İncele