Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Gul, Muhammet(85)
- Serdar, Osman(72)
- Güler, Ömer(68)
- Akkurt, Nevzat(61)
- Baskonus, Haci Mehmet(54)
- Alataş, Mevlüt(53)
- Paksoy, Mehmet Yavuz(53)
- Yucesan, Melih(53)
- Bulut, Hasan(51)
- Tekin, H.O.(51)
- ALMisned, Ghada(48)
- Yildirim, Numan(48)
- Benzer, Fulya(47)
- Kocabaş, Mehmet(45)
- Yildirim, Nuran Cikcikoglu(44)
- Kutlu, Banu(41)
- Ince, Muharrem(39)
- Zengin, Gokhan(39)
- Batan, Nevzat(37)
- Utku, Anıl(35)
- Celik, Erkan(33)
- Topal, Murat(32)
- Ezer, Tülay(31)
- Tanyol, Mehtap(31)
- Can, Erkan(30)
- Sulaiman, Tukur Abdulkadir(29)
- Aslan, Naim(28)
- Özkul, İskender(28)
- Aslan, Alper(27)
- Cakilcioglu, Ugur(27)
- Erguven, Gokhan Onder(27)
- Kutluyer, Filiz(27)
- Kök, Mediha(27)
- Ates, Mehmet(26)
- Erten, Fusun(26)
- Kahraman, Gökhan(26)
- Onat, Onur(26)
- Dal, Nursel Alp(25)
- Danabas, Durali(25)
- Say, Yakup(25)
Yayınlar
- MakaleYalnız künye2025Scopus SJRQ4Induced breeding and seed production of seurukan fish (Osteochilus jeruk) using synthetic reproductive hormones
Muchlisin, Zainal Abidin; Tasnarizki, Dwimutia; Risky, Muhammad; Diani, Diani; Naurah, Aufa; Dewi, Cut Dara; Maulida, Siti; Razi, Nanda Muhamamd; Rahayu, Sri Riska; Handayani, Luvi Syafrida
The commercial aquaculture of seurukan fish (Osteochilus jeruk) is common in Indonesia; however, seed availability from the wild is limited. Therefore, induced breeding technology in seurukan fish using synthetic reproductive hormones is crucial. This study evaluated the efficacy of five different types of synthetic reproductive hormones and their corresponding doses on the reproductive performance of seurukan fish in captivity. The methodology consisted of two experiments; first, four types of synthetic reproductive hormones were tested: ovaprim, ovaspec, human chorionic gonadotropin (HCG), and ovalumon. Second, several doses of ovaprim hormone were stested with doses of 0.25, 0.50, 0.75, and 1.0 ml kg-1 body weight. The results showed that ovaprim, ovaspec, and HCG successfully induced ovulation and spawning in seurukan fish. The hormones significantly affected the latency period, number of eggs released, fertilization, and survival rates (P<0.05), but did not significantly affect the hatching rate and survival of larvae (P>0.05). Ovaprim produced better egg quality compared to ovaspec and HCG. In the second experiment, the results showed a significant difference in the latency period and egg size (P<0.05) of fish treated with varying doses of ovaprim hormone. The hormone doses did not significantly affect the number of eggs, hatching rate, fertilization rate, survival rate, or larval survival (P > 0.05). The dose of 0.5 ml kg-1 BW of ovaprim produced the best results. Therefore, a dose of 0.5 ml kg-1 BW was recommended as an effective dose for induced spawning and seed production of seurukan fish.
AtıfScopus2
İncele - MakaleAçık Erişim2025Scopus SJRQ2A novel additive for enhancing biomass energy production from agro-industrial wastes: synthesis of hydrophobic nanoporous silica aerogel and its effect on methane production
Gulsen Akbay, Habibe Elif; Basgoz, Oykum; Guler, Omer
Anaerobic digestion (AD) is one of the most preferred processes for the treatment of organic waste. However, additional processes such as co-digestion, pretreatment, and additive addition continue to be explored to remove the limits on the applicability of AD. This study investigated the effects of hydrophobic nanoporous silica aerogel (NpSA) synthesized from waste rice husks on the anaerobic co-digestion (AnCD) of the mixture consisting of sewage sludge and fruit processing industry wastes. All bioreactors containing NpSA-free, 0.1 g, 0.2 g, 0.5 g, and 1 g NpSA (0.03–0.3 gNpSA/gVSadded) were operated in a mesophilic-batch process. Biogas and methane yields increased from 346 mL/gVS (NpSA-free) to 387 mL/gVS and from 231 mL/gVS (NpSA-free) to 288 mL/gVS, respectively, with 0.1 g NpSA addition. NpSA additive increased biogas production in all bioreactors compared to the blank. However, biogas production rate and methane content increased faster at lower doses of NpSA. Maximum soluble chemical oxygen demand (sCOD), protein, carbohydrate, and volatile solid (VS) reductions were between 45–71%, 35–54%, 44–65%, and 34–91% for NpSA added mixtures, respectively. The hydrophobic NpSA additive was effective in improving the AnCD performance and biogas/methane production. Experimental results fit the kinetic models frequently preferred in such AD processes. In addition, the possible energy and financial potential of the produced methane were also discussed, and it was determined that the direct sale of methane gas produced by the addition of NpSA in the global market could provide 1.4 $/Lmixture more financial gain than the mixture NpSA-free.
AtıfWoS1
İncele - MakaleAçık Erişim2025Scopus SJRQ1Exploring the anticancer potential of Dianthus orientalis in pancreatic cancer: A molecular and cellular study
Yildirim, Mehmet Aykut; Sevinc, Burak; Paydas, Samet; Karaselek, Mehmet Ali; Duran, Tugce; Kuccukturk, Serkan; Vatansev, Hakan; Cetiz, Mehmet Veysi; Caprioli, Giovanni; Acquaticci, Laura
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, characterized by limited therapeutic options and poor prognosis. This study investigated the anticancer effects of Dianthus orientalis extracts on pancreatic cancer cell lines (Panc-1 and BxPC-3) with a focus on apoptosis, invasion, and metastasis-related pathways. Chemical analysis using HPLC-MS/MS identified bioactive compounds (vanillic acid, syringic acid, p-coumaric acid, quercetin, hyperoxide) known for their anticancer properties. The Inhibitory Concentration 50 (IC50) value, which is half maximal inhibitory concentration of cancer cells, was determined to be 250 μg/mL at 48 h, and significantly induced apoptosis by decreasing anti-apoptotic gene expressions (Bcl-XL and Bcl-2) and increasing pro-apoptotic gene expressions (Casp3 and Bax) particularly in the Panc-1 cell line. Flow cytometric analysis revealed approximately 55% apoptosis in both cell lines. Molecular docking and dynamics analyses demonstrated strong binding affinities of quercetin and hyperoxide with important cancer-related proteins, including CHEK2 and PALB2. Gene expression analysis demonstrated the upregulation of pro-apoptotic markers like Bax and Casp3, and selective modulation of metastasis-related genes such as SNAI1, PALB2, and CHEK2. The findings highlight the potential of D. orientalis to modulate DNA repair mechanisms and epithelial-mesenchymal transition (EMT) pathways. Furthermore, network pharmacology and in silico tools corroborated its interactions with critical signaling pathways in cancer progression, including PI3K-Akt and MAPK. The study provides the first comprehensive evidence of D. orientalis's antiproliferative through apoptosis induction on pancreatic cancer cell lines, laying the groundwork for future therapeutic applications.
AtıfScopus19İncele - MakaleYalnız künye2025Scopus SJRQ1Patterns and Predictors of Nurse Turnover Intentions Based on Years of Nursing Experience: A Cluster Analysis Approach
Baris, Veysel Karani; Yesiltepe, Akgun; Celik, Gulbahar
Aim: To identify patterns and predictors of nurse turnover intentions based on years of nursing experience using a cluster analysis approach. Background: Nurses with varying years of experience have different characteristics. These differences can also lead to distinct patterns and predictors of turnover intentions. Methods: For this descriptive study, 785 nurses from hospitals across different regions of Türkiye participated in a survey. Data was collected through online questionnaires between April and May 2022. The K-means unsupervised machine learning algorithm was employed to classify nurses into distinct clusters based on their experience. Multiple linear regression analyses were conducted to identify the predictors of turnover intention specific to each cluster. The STROBE guideline was followed for reporting. Results: Cluster analysis grouped nurses into three categories by experience level: low, medium and high. The medium-experience group had the highest turnover intention, whereas the high-experience group had the lowest. Work stress was the only common predictor across all groups. Low income predicted turnover only for the low-experience group, and gender was significant only for the medium-experience group. Conclusion: This study revealed that turnover intention and its predictors vary by experience level, indicating a need for retention strategies tailored to nurses' years of experience. By considering subgroup characteristics, policymakers can develop targeted interventions to enhance nurse retention.
- MakaleYalnız künye2025Scopus SJRQ1Mechanical, durability and microstructure properties of eco-friendly self-compacting mortars with addition of volcanic scoria, silica fume and boron waste as cement replacement
Şahin Yön, Merve
The objective of this experimental study is to investigate the mechanical and durability performances of self-compacting mortars containing industrial waste and natural stone to develop an environmentally friendly mortar. Binary series of boron waste (B), silica fume (S) and volcanic scoria (V) were formed by substituting up to 95 % by weight with Portland cement, and ternary series were formed by substituting up to 80 % by weight with Portland cement. A total of 14 mixtures and one reference mixture (R) were improved for the purpose of investigating the workability, mechanical strength and durability properties of self-compacting mortar with different binder compositions. Samples of 40x40x160 mm were produced to evaluate mechanical properties and freeze-thaw effect, 100x100x100 mm for abrasion testing and 50x50x50 mm to determine physical properties. Additionally, SEM/EDS and XRD analyses were performed to determine the microstructural characteristics of the mixtures formed. The test results demonstrated that the sole replacement of boron waste with Portland cement resulted in enhanced fluidity. Nonetheless, the 90-day compressive strengths of the S10V20 and B5S10V5 mixtures exhibited increases of 7.47 % and 5.57 %, respectively, relative to the reference, whilst the B15 series saw a 52.5 % reduction, marking the lowest 90-day compressive strength compared to the reference sample. When the freeze-thaw effect was assessed after 136 cycles, the compressive strength diminished by 8.57 %, 13.1 %, 4.13 %, 7.28 %, 6.22 %, 24.77 %, and 48.1 % in the R, B5, V5, V10, V15, B5S10V5, B5S10V10, and B5S10V15 samples, respectively. Among the samples subjected to abrasion tests, a loss of 6.5 per thousand occurred in the mass of the reference sample at the end of 6 minutes, while a loss of 11 per thousand occurred in the binary mixture containing 5 % B, which had the highest abrasion.
AtıfScopus16WoS14OpenAlex16İncele - MakaleAçık Erişim2025Scopus SJRQ2Effects of ZrN and DLC coatings on morphostructural, corrosion, cell viability, and antibacterial properties of Ti6Al4V scaffolds
Aslan, Naim; Aksakal, Bünyamin; Cihangir, Salih; Fidan, Ferzan; Yilmazer, Yasemin
Lightweight and functional metallic materials are consistently favored and attract significant attention in the biomedical field. This study investigates the influence of ZrN and DLC coatings on Ti6Al4V scaffolds with varying porosities (40%, 50%, 60%) for biomedical applications. PVD-deposited coatings exhibited distinct growth mechanisms: High-resolution SEM-FIB analyses revealed columnar ZrN structures due to limited adatom mobility, while DLC formed conformal, amorphous layers via high-energy carbon species. Corrosion resistance decreased in 40% porous DLC and 60% porous ZrN-coated samples, likely due to coating defects and increased electrolyte access through open pores. ZrN coatings showed superior antibacterial activity and attributed to surface reactivity and potential ion release. In contrast, the uncoated 60% porous scaffolds demonstrated highest cell viability, suggesting that excessive coating on highly porous structures may hinder cell–material interactions. Furthermore, the cytotoxicity evaluations indicated that uncoated scaffolds exhibited the highest cell viability (77.51%) at 60% porosity after 48 hours, with ZrN coatings demonstrating better efficacy compared to DLC in the 50% and 60% porosity groups.
AtıfScopus3WoS3OpenAlex3İncele - MakaleAçık Erişim2025Scopus SJRQ2PCL/chitosan composite films enhanced with Bi2O3 in nuclear shielding applications: Irradiation resistance, thermal and structural properties
Yılmaz, Demet; Pekdemir, Mustafa Ersin; Dik, Gamze; Selçuk Pekdemir, Sibel; Ulu, Ahmet; Taşgın, Yahya; Ateş, Burhan
In this work, irradiation resistance, thermal, and structural characteristics of Bi2O3-reinforced poly ε-caprolactone/chitosan composites for nuclear shielding applications were studied. PCL/CTS/Bi2O3 composite films were prepared by using different amounts of Bi2O3 (0.5%–4.0% (w/v)). The radiation shielding parameters of the synthesized composite films were both experimentally and theoretically measured at the high energy region. The equivalent dose rates of the prepared film samples were measured using a fast neutron source. Also, to determine the irradiation resistance, the samples were irradiated with Am-241 and Co-60 sources for 30 days. The MFP values at 80.99 keV changed by approximately 61% in samples PCL/CTS and PCL/CTS/4% Bi2O3. The results show that Bi2O3 content increases the gamma shielding abilities in PCL/CTS films. According to TGA results, the thermal stability of the polymer composite films is increased by the addition of Bi2O3 to the PCL/CTS blend film. The results show that PCL/CTS composite materials can be used as protective coating materials for nuclear shielding. Highlights: PCL/CTS/Bi2O3 composite films were prepared by the solvent casting method. The thermal stability of the composite films increased by increasing the Bi2O3 amount. Bi2O3 increased the LAC and MAC values of the composite films. PCL/CTS/Bi2O3 composite films have a neutron shielding effect.
AtıfScopus5WoS5İncele - MakaleAçık Erişim2025Scopus SJRQ2Species classification of microalgae using a CNN-based deep learning approach under optimal cultivation conditions
Simsek, Gokce Kendirlioglu; Ertargin, Merve; Pezzolesi, Laura; Pistocchi, Rossella; Yildirim, Ozal; Cetin, A. Kadri
Microalgae possess significant potential in a wide range of applications due to their valuable bioactive compounds. They are utilized in biofuel production to reduce dependence on fossil fuels, in wastewater treatment for the biological removal of heavy metals and pollutants, in carbon capture for mitigating climate change, and in the pharmaceutical and nutraceutical industries as supplements. As their applications expand, the accurate and efficient identification of microalgal species becomes increasingly important. Traditional classification methods are time-consuming and rely heavily on expert knowledge. The main aim of this study is to develop a reliable, fast, and expert-independent deep learning-based approach for the classification of microalgae species using microscopic images. In this context, deep learning techniques, specifically convolutional neural network (CNN)-based models were employed to classify microalgal species. Four widely used pre-trained CNN architectures (ResNet152, DenseNet201, MobileNetV2, and EfficientNetB0), along with a custom-designed CNN, were implemented. The models were trained and tested on a labeled dataset consisting of microscopic images of Chlorella vulgaris, Scenedesmus acutus, and Haematococcus pluvialis. The classification models achieved accuracy rates ranging from 96.87 % (Custom CNN) to 100 % (DenseNet201), demonstrating the potential of CNN-based approaches in automating and improving microalgae species identification.
AtıfScopus5WoS5OpenAlex5İncele - MakaleYalnız künye2025Scopus SJRQ1Identification and source provenance of jadeite-bearing jade axes from Ulucak Höyük, Western Anatolia
Sayit, Kaan; Çevik, Özlem; Aktağ, Alican; Erdoğu, Burçin; Bamyacı, Onur; Vuruşkan, Osman; Sivil, Coşkun
The jades from Ulucak Höyük (İzmir, Turkey) are green-colored in hand specimen, and combined petrographic, XRD, and whole-rock analyses indicate that they mainly comprise jadeitic clinopyroxene, characterizing them as jadeite-bearing jades. Primitive mantle (PM)-normalized multi-element patterns reveal two distinct chemical groups. Both groups display depletion in Th and U; however, Group 1 shows a narrower elemental range and marked positive Pb anomaly. The second group, on the other hand, displays a wide elemental range in most elements and strong negative anomalies in Zr and Hf ([Nd/Zr]PM = 1.6–4.2; [Sm/Hf]PM = 1.8–3.5). Regarding REE systematics, both groups are characterized by weak positive slopes ([La/Yb]Ch = 1.7–5.3). However, whereas Group 1 shows coherent LREE-enriched trends, Group 2 displays flat- to LREE-enriched patterns with a wide range in Eu. When the geochemical features of Ulucak jades are compared with the high-pressure (HP) metamorphic rocks from Turkey and Greece, the similar multi-element patterns of Syros eclogites (Greece) to Group 2 Ulucak jades make Syros a possible source area for the Ulucak artefacts. On the other hand, the geochemical resemblance of the Sifnos jadeite-bearing gneisses to Group 1 Ulucak jades may raise the possibility of this island being another source for the Ulucak jades.
- MakaleYalnız künye2025Scopus SJRQ3Eco-Friendly and Practical Electrochemical Determination of Lactic Acid in Milk Using Boron Doped Diamond Electrode
İpek, Yeliz.; Koçak, Berna; Keçeci, Ali
In this study, an economical, environmentally friendly, sensitive, selective, and rapid voltammetric quantitative analysis method was developed using a boron doped diamond electrode to determine lactic acid (LA). Two linear working ranges were determined for LA determination in phosphate buffer solution (PBS, pH of 2). The first linear working range (LR1) was between concentrations of 1.5 × 10−6–8 × 10−6 mol· L−1, with a detection limit of 1.3 × 10−6 mol·L−1, and the limit of quantification (LOQ) was found to be 4.4 µmol· L−1. The second linear working range (LR2) was determined in the concentration range of 8.0–89.2 µmol·L−1. LOD was calculated as 15.8 µmol·L−1, and the LOQ value was calculated as 52.6 µmol·L−1 in the LR2. Intraday repeatability of the BDD electrode for LA determination was (RSD) 6.8% in LR1 and 11.8% in LR2. The interday repeatabilities of the BDD electrode in LR1 and LR2 were calculated as 7.7% and 4.7%, respectively. The developed electrochemical sensor was successfully applied for the determination of LA in milk sample. The sensor exhibited a short response time of about 10 s in PBS at pH 2. The recovery values of LA in PBS and milk sample were 97.3% and 96.1%, respectively.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2025Scopus SJRQ3First Recording of Melanopsis costata (Olivier, 1804) in Anamur (Dragon) Stream and Göksu River, Mersin, Türkiye and Measurement of Some Biometric Parameters
Kutluyer Kocabaş, Filiz; Kocabaş, Mehmet
In this study, some biometric characteristics of the freshwater snail Melanopsis costata (Olivier, 1804) were determined in the Anamur (Dragon) Stream and Göksu River (Mersin, Turkey). Weight (A) (g), shell width (KG) (mm), shell height (KY) (mm), aperture length (AU), and width (AG) (mm) measurements were made on the samples taken from different stations. Morphological relationships were determined by multivariate statistical evaluation. The highest values in terms of shell length and weight were evaluated as 24.46 mm and 1.496 g in Karakaya Village (Göksu River). The data were evaluated with Principal Component Analysis (PCA), a flexible statistical method used to understand the relationships between variables and explain a large part of the data set. Samples taken from different stations showed a strong relationship between aperture width and spir height. The species is not mentioned as a new record in the study area.
AtıfScopus1OpenAlex1
İncele - MakaleYalnız künye2025Scopus SJRQ2The impact of global value chains on climate change
Ateş, Erdem; Şanlısoy, Selim
Climate change can be defined as the increase in average temperatures due to rising greenhouse gas (GHG) emissions, predominantly due to human activities. Carbon emissions have increased at an alarming rate with the emergence of globalization, with its accompanying global value chain, and the consequent increase in global production volume with its polluting sectors. To combat this alarming situation, production with environmentally friendly technologies has emerged recently, and developing countries are embracing more and more costly environmentally friendly production techniques, although they are disadvantaged when it comes to covering the costs. However, it has been observed that they stay behind in this race to adopt environmentally friendly techniques compared to developed countries. The aim of the study, which is a novel contribution to the existing literature, is to examine the relationship between the global value chain and climate change by considering the distinction between developed and developing countries. The study used the data of 156 countries from the years 2000–2018. The results obtained from the generalized method of moments (GMM) show that participation in global value chains has different effects in developed and developing countries regarding carbon emissions. When the level of participation in GVC (global value chain) and FVA (foreign value added) increases, countries’ carbon emissions decrease, and it increases when the DVA (domestic value added) level increases. As a result, in particular, developing countries should green their production methods, and for this purpose, financial support mechanisms should be established.
AtıfScopus8WoS4OpenAlex7İncele - MakaleAçık Erişim2025Scopus SJRQ1Transauricular vagal nerve stimulation suppresses inflammatory responses in the gut and brain in an inflammatory bowel disease model
Atalar, Kerem; Alim, Ece; Yigman, Zeynep; Belen, Hayrunnisa Bolay; Erten, Fusun; Sahin, Kazım; Soylu, Ayse; Dizakar, Saadet Ozen Akarca; Bahcelioglu, Meltem
Inflammatory bowel disease (IBD) encompasses Crohn's disease (CD) and ulcerative colitis (UC), is a major health problem on a global scale and its treatment is unsatisfactory. We aimed to investigate the effects of transauricular vagal nerve stimulation (tVNS) on inflammation in rats with IBD induced by trinitrobenzene sulfonic acid (TNBS). A total of 36 adult female Sprague–Dawley rats were given TNBS, or vehicle, and tVNS, or sham, every other day for 30 min for 10 days. Postmortem macroscopic and microscopic colon morphology were evaluated by histological staining. Additionally, IL-1β, IL-6, IL-10, and TNF-α cytokine levels in the colon and the brain were evaluated by immunohistochemistry and western blotting analysis. TNBS induced epithelial damage, inflammation, ulceration, and thickened mucosal layer in the colonic tissues. Administration of tVNS significantly ameliorated the severity of TNBS-induced tissue damage and inflammatory response. TNBS also alters pro-inflammatory and anti-inflammatory balance in the brain tissue. TVNS application significantly suppressed the protein levels of pro-inflammatory cytokines, namely IL-1β, IL-6, and TNF- α while augmenting the level of anti-inflammatory cytokine IL-10 in the colonic and the brain tissue. We have shown that TNBS-mediated colonic inflammation and tissue damage are associated with neuroinflammatory responses in the brain tissue. Also demonstrated for the first time that neuroinflammatory response in the gut-brain axis is suppressed by tVNS in the IBD model. Non-invasive tVNS stands out as a new potential treatment option for types of IBD.
AtıfScopus13OpenAlex12
İncele - MakaleYalnız künye2025Scopus SJRQ2Heat transfer and condensation analysis of the walls of a house built with natural andesite stone
Işik, Erdem; Kahraman, Gökhan; Atalar, Aydın
The use of natural stones in buildings is increasingly popular due to both their decorative appearance and their thermal performance. Proper use of these stones in buildings is crucial for energy conservation and preventing condensation within structural components. This study investigated heat transfer and condensation in the wall of a house made from natural andesite stone in Iğdır, Turkey, under steady-state conditions and different wall combinations. Samples were created from natural stones extracted from two different elevations in the foothills of Mount Ararat, with measured thermal conductivity values of 1.73 W/m·K (higher elevation– Haverage) and 1.31 W/m·K (lower elevation– Laverage). In the wall model using a 3-cm thick insulation board between two natural stones from the higher elevation, condensation occurred on the outer surface of the insulation layer. This can negatively impact the durability and thermal performance of the structure, and such design should be avoided. The highest heat flux of 18.27 W/m² was observed in the non-insulated wall made of higher elevation stones, while the lowest heat flux of 6.68 W/m² occurred in the model using a 3-cm insulation board between two lower elevation stones. No condensation risk was found in this configuration. The difference between the worst and best cases in terms of heat flux was approximately threefold, emphasizing the importance of proper material selection and insulation design. These findings provide guidance for energy-efficient building design using natural stone.
- MakaleAçık Erişim2025Scopus SJRQ2Synthesis and characterization of novel bis(thiosemicarbazone) complexes and investigation of their acetylcholinesterase and glutathione S-transferase activities with in silico and in vitro studies
Donmez, Melike; Sekerci, Memet; Adiguzel, Ragip; Oğuz, Ercan; Türkan, Fikret; Yildiko, Umit; Colak, Naki
In this study, firstly, bis(thiosemicarbazone) ligand [L: 2,2′-(2-(2-(4-methoxyphenyl)hydrazineylidene)cyclohexane-1,3-diylidene)bis(hydrazine-1-carbothioamide)] was synthesized by the condensation reaction of thiosemicarbazide and ketone compound (2-(2-(4-methoxyphenyl)hydrazone)cyclohexane-1,3-dione). The metal complexes were synthesized by the reaction of obtained ligand (L) with CuCl2·2H2O, NiCl2·6H2O, CoCl2·6H2O, and MnCl2·4H2O salts. The structures of synthesized ligand and their complexes were characterized using elemental analysis, IR, UV–Vis, 1H-NMR spectra, 13C-NMR spectra, magnetic susceptibility, mass spectra (LC–MS), thermogravimetry analysis-differential thermal analysis (TGA-DTA), and differential scanning calorimetry techniques. According to the results of the analysis, square plane geometry was suggested for Cu and Co complexes. However, the structures of Ni and Mn complexes were in agreement with octahedral geometry. Molecular docking analysis and pharmacological potential of the compound were evaluated to determine the inhibitory potential against acetylcholinesterase (AChE) and Glutathione-S-transferases (GST) enzymes. The compound exhibited strong binding/docking indices of − 5.708 and − 5.928 kcal/mol for the respective receptors. In addition, L–Ni(II) complex was found to be the most effective inhibitor for AChE enzyme with a Ki value of 0.519. However, with a Ki value of 1.119, L–Cu(II) complex was also found to be an effective inhibitor for the GST enzyme.
AtıfScopus21OpenAlex19İncele - MakaleAçık Erişim2025Scopus SJRQ1Evaluation of Green Deal compliance performance with a hybrid comparative multi-attribute decision model
Karadag, Mehmet; Gul, Muhammet; Yucesan, Melih; Ortiz-Barrios, Miguel; Ishizaka, Alessio; Khan, Jehangir
The environmental and economic transformation initiated by the European Green Deal is influencing not only EU member states, but also other countries engaged in trade with the EU. This transformation mandates a shift towards sustainable practices in sectors such as agriculture, industry, transportation, energy, and finance. Compliance with the Green Deal is increasingly crucial for countries, particularly those with significant commercial ties to the EU. However, differing levels of development lead to varying degrees of implementation. While studies on the Green Deal compliance of EU member states exist, an evaluation of Türkiye—a candidate EU member with substantial trade relations—would address a significant gap in the literature. This study introduces a novel hybrid comparative multi-attribute decision model that combines subjective (Best Worst Method and its derivatives) and objective (Entropy) weighting to determine the relative importance of 14 sub-criteria under three main criteria: “Reducing” the impacts of climate change, “Protecting” the planet and health, and “Enabling” a green and just transition. Using the Ratio Product Model (RPM), Türkiye's Green Deal compliance from 2017 to 2021 was evaluated. Sensitivity analysis was conducted to validate the robustness of the findings, and comparisons were made using various multi-attribute decision models, including SAW, TOPSIS, and VIKOR, as well as benchmarking against EU countries. The criteria weights, derived from a combination of subjective and objective methods, highlighted the dominant importance of the “Reducing” criterion across all methods. The “Enabling” and “Protecting” criteria showed slight variations in importance depending on the method. The RPM results indicated that 2021 was Türkiye's best-performing year in terms of Green Deal compliance, while 2017 showed the weakest performance. Despite some fluctuations between 2018 and 2019, Türkiye demonstrated significant progress overall. The study not only advances the methodology for evaluating Green Deal compliance but also provides actionable insights for policymakers and industry stakeholders, enabling more informed decision-making. By highlighting Türkiye's trajectory, the findings offer strategic guidance for non-EU countries aiming to align with Green Deal objectives, fostering sustainable development and strengthening economic ties with the EU.
AtıfScopus11OpenAlex11İncele - MakaleYalnız künye2025Scopus SJRQ3Development of alternative carbon fibre powder and rare earth element-based filler for high density polyethylene; [Entwicklung von alternativen Kohlenstofffaserpulvern und Seltene Erden-basierten Füllstoffen für Polyethylen hoher Dichte]
Ayikurt, P.; Kısmet, Y.; Dogan, A.; Höchstötter, K.H.; Fiedler, B.
This study developed alternative fillers to enhance the flowability of high-density polyethylene (HDPE). Lanthanum and cerium oxide with over 90 % purity were used as binder interfacial elements in fillers developed using both carbon fiber powder wastes and powder coating wastes. Polyethylene gel was used to make the fillers thermoplastic and homogenous. A total of six different fillers were developed and melt flow index analyses were performed. As a result of these analyses, it was found that the fluidity of high-density polyethylene improved significantly, especially with fillers containing carbon fiber powder. As a result, high-density polyethylene mixtures containing 10 %, 20 %, 30 %, 40 %, and 50% by weight of carbon fiber powder-based fillers were pressed into molds by a plastic injection molding machine, and samples were produced. According to the mechanical analysis results of these specimens, tensile and flexural strengths decreased slightly depending on the filling ratio, while the impact strengths remained constant. Differential scanning calorimetry analysis was performed to determine the glass transition temperature and melting/crystallization temperatures of the obtained mixtures, while thermogravimetric analysis was performed to determine the mass losses. At the same time, electron microscope analysis of the cross sections of the samples were performed.
- MakaleAçık Erişim2025Scopus SJRQ1Assessing Motor Performance and Ankle Mobility in Pre-Adolescent Male Fencers
Aydin, Yalcin; Tokgoz, Gurkan; Yilmaz, Nurkan; Coskun, Ilgin Ali; Beykumul, Aysegul; Colak, Enes; Aygoren, Caner; Koc, Samet; Cinarli, Fahri Safa
Ankle mobility plays a critical role in dynamic stability and propulsion during fencing-specific actions. However, its relationship to performance metrics in young athletes remains unclear. This study aimed to investigate the relationship between ankle range of motion (ROM), acceleration, and jump height in pre-adolescent male fencers, as well as to examine bilateral differences in ankle mobility between the front and rear foot. Fifteen fencers (age 10.86 ± 0.91 years) were assessed for ankle ROM (dorsiflexion, plantar flexion, inversion, eversion) using a goniometer. Performance tests included a 7 m sprint lunge (acceleration) and countermovement jump. Significantly large correlations were observed between front and rear foot ankle plantar flexion range of motion and both acceleration (r = 0.625–0.628, p < 0.05) as well as vertical jump height (r = 0.579–0.647, p < 0.05). Rear foot ankle plantar flexion range of motion significantly predicted acceleration (r2 = 0.335, p < 0.05) and jump height (r2 = 0.418, p < 0.05). In contrast, no meaningful associations were found between dorsiflexion, inversion, or eversion range of motion and performance metrics. Additionally, bilateral comparisons revealed significantly greater dorsiflexion in the front foot ankle and greater eversion in the rear foot ankle (p < 0.05). Plantar flexion ROM is a key contributor to acceleration and jump capacity in youth fencers. Incorporating ankle mobility training may support physical development in this population.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2025Scopus SJRQ1Effects of Integrated Extracts of Trigonella foenum-graecum and Asparagus racemosus on Hot Flash-like Symptoms in Ovariectomized Rats
Erten, Fusun; Er, Besir; Ozmen, Ramazan; Tokmak, Muhammed; Gokdere, Ebru; Orhan, Cemal; Morde, Abhijeet A.; Padigaru, Muralidhara; Sahin, Kazim
Vasomotor symptoms, such as hot flashes (HFs), commonly affect women during menopause, leading to a reduced quality of life. The current study evaluates the combined effect of active components Asparagus racemosus (AR) and Trigonella foenum-graecum (TFG) in a single oral formulation (IAT) for alleviating menopausal symptoms in ovariectomized rats. Following bilateral ovariectomy, the animals were randomly assigned to nine groups: (1) Control, (2) Ovariectomy (OVX), (3) OVX+TA1 (TA: Combination of Trigonella and Asparagus; TFG 30 mg/kg + AR 30 mg/kg), (4) OVX+TA2 (TFG 30 mg/kg + AR 15 mg/kg), (5) OVX+TA3 (TFG 15 mg/kg + AR 30 mg/kg), (6) OVX+TA4 (TFG 40 mg/kg + AR 30 mg/kg), (7) OVX+TA5 (TFG 30 mg/kg + AR 40 mg/kg), (8) OVX+IAT1 (IAT: Integrated Asparagus and Trigonella; TFG+AR integrated extract, 30 mg/kg), and (9) OVX+IAT2 (TFG+AR integrated extract, 60 mg/kg). On the 8th day of treatment, tail and skin temperatures were recorded every 30 min for 24 h. Ovariectomized rats exhibited menopausal symptoms, such as hormonal imbalances and elevated skin temperature. Administration of AR, TFG, and IAT significantly decreased serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and cortisol while increasing estradiol, progesterone, and dopamine (p < 0.0001), effectively alleviating hot flash-like symptoms. Additionally, they mitigated ovariectomy-induced oxidative stress by lowering malondialdehyde (MDA) levels and restoring antioxidant enzyme activity. Ovariectomized rats exhibited increased expression of a proto-oncogene (c-FOS), gonadotropin-releasing hormone (GnRH), Kisspeptin, Neurokinin B (NKB), and Transient receptor potential vanilloid 1 (TRPV1), along with reduced expressing brain-derived neurotrophic factor (BDNF) levels, which were reversed by treatment, especially with the IAT2 combination. The AR and TFG combination, particularly in IAT formulations, showed strong potential in alleviating menopausal symptoms in ovariectomized rats. These findings suggest that the combination of AR and TFG extracts could be a natural alternative for managing postmenopausal symptoms by restoring reproductive hormone levels, regulating lipid profiles, and enhancing antioxidant defense systems.
AtıfScopus8WoS8OpenAlex6İncele - MakaleYalnız künye2025Scopus SJRQ2Effects of Trace Rare Earth (TRE) additions on thermal, crystal structure, and radiation shielding properties of CuAlMn high-temperature S-M alloys: A closer look at Cerium effect
Kalay, Ece; Özkul, İskender; Karaduman, Oktay; Kızılgün, Yasin; Güler, Ömer; Canbay, Canan Aksu; Kilic, G.; Baykal, Duygu Sen; ALMisned, Ghada; Tekin, H.O.
This study systematically investigates the effect of Ce addition on the thermal, structural, and radiation shielding properties of CuAlMn-based high-temperature shape memory alloys (HTSMAs). Among the different compositions, Ce-III demonstrated the most balanced performance, exhibiting optimized phase transformation behavior, microstructural refinement, and enhanced gamma-ray attenuation. Differential Scanning Calorimetry (DSC) analysis revealed that Ce-III exhibited lower transformation temperatures, with austenite start (As) and finish (Af) temperatures of 378.13 °C and 429.75 °C, respectively, and martensite start (Ms) and finish (Mf) temperatures of 402.52 °C and 341.91 °C, suggesting improved thermal stability. Microstructural analysis indicated significant grain refinement, attributed to Ce's dislocation pinning effect, which contributed to enhanced strength and radiation attenuation. X-ray diffraction (XRD) patterns confirmed the formation of Ce-rich intermetallic phases, such as Mn1.15Cu3.85Ce and Cu8Ce4, which increased density and photon interaction probability. The Ce-III alloy exhibited superior linear attenuation coefficients and reduced half-value layer, reinforcing its effectiveness as a radiation shielding material. It can be concluded that Ce-III represents an optimal composition with a synergistic combination of structural stability, phase transformation control, and enhanced radiation shielding capabilities, making it a promising candidate for nuclear and high-radiation applications.
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