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MakaleYalnız künye2022Scopus SJRQ2/r/munzur/2532
Investigation of electrical conductivity and bioactive quality during ohmic evaporation process of Apple juice
Karakavuk, Emrah; Goksu, Ali; Sabanci, Serdal
In this study, the evaporation of apple juice was completed with ohmic heating to eliminate some problems with conventional evaporation methods. Ohmic evaporation (OE) was performed at different voltage gradients (13–17 V/cm) for determining electrical conductivity (EC), Hydroxymethylfurfural (HMF), and the total phenolic content (TPC) changes. The voltage gradient affected the total consumed energy, average power, and specific water removal ratio (SWRR) values (p <.05). The shortest time was obtained at 17 V/cm, while the longest time was 13 V/cm during the OE process. The EC value varies between 0.19–0.85 S/m for the voltage gradients. EC and current values increase with temperature until boiling starts, then decrease, and the EC value tends to increase slightly. The TPC value ranged between 587.4–716,4 mg GAE/100 g and was higher at OE than in the conventional process. As a result, the OE process preserves the TPC value of apple juice better while shortening the processing time. Novelty impact statement: The ohmic evaporation process is an alternative method that can be preferred in concentrating fruit juices with consuming less energy and obtaining higher quality products. In addition, considering the phenolic distribution, it was determined in this study that the products were better preserved in the ohmic evaporation process. It is predicted that it will provide important data for both pilot and industrial designs for the establishment of any ohmic evaporation systems.
AtıfScopus6WoS5OpenAlex9
İncele
MakaleAçık Erişim2022Scopus SJRQ2/r/munzur/2520
Investigation of the effect of the life satisfaction and psychological well-being of nursing students on their happiness levels
Yeşi̇ltepe, Akgün; Sayar, Serap; Çal, Ayşe
Purpose: This study aims to examine the effect of nursing students' life satisfaction and psychological well-being on their perceived happiness levels. Method: The study, which was designed as a descriptive and cross-sectional study was carried out in Turkey with 264 students of nursing. Findings: Students' life satisfaction and happiness (r = 0.722), psychological well-being and happiness (r = 0.743), and psychological well-being and life satisfaction (r = 0.689) were found to be positively and highly correlated. Students' gender and perception of income status and general health status affected their happiness levels. It was revealed that life satisfaction and psychological well-being predict happiness (63.6%). Practice implications: The factors of life satisfaction and psychological well-being play a decisive role in the happiness of nursing students.
AtıfScopus19WoS18OpenAlex20
İncele
MakaleYalnız künye2022Scopus SJRQ2/r/munzur/2509
Performance evaluation of pectin extraction from grapefruit peel powder by ohmic heating
Goksu, Ali; Duran, Gülseven; Çilingir, Seda; Çevik, Mutlu; Sabanci, Serdal
This study is to investigate the performance properties during the extraction of pectin from grapefruit peel powder using ohmic heating. Pectin extraction was carried out under different voltage gradients (7–11 V/cm), different solid: liquid ratios (1:20–1:60), and different holding times (0–180 min) at constant pH and temperature (80°C). The voltage gradient and solid: liquid ratio affected the time to reach the target temperature. The highest energy efficiency value for all voltage gradients and solid: liquid ratios were obtained in the 0 min holding time, and the efficiency value, which changed between 89.47% and 56.02%, was negatively affected by the increase in the holding time. The exergy efficiency was lower than the energy efficiency and decreased due to the increasing holding time and decreasing voltage gradient. Also, the exergy efficiency was found to be between 73.69% and 18.09%. Determining the performance characteristics of the system will make a significant contribution to pilot and industrial-scale system/process applications for the future. Practical application: In this study, pectin was successfully obtained from grapefruit powder using an ohmic heating system. The operating conditions for the obtained pectin include constant pH (pH:1) and temperature (80°C) but various voltage gradients, solid: liquid ratios, and extraction times. It has been observed that voltage gradient and extraction time were effective on energy efficiency. When looking at exergy efficiency, voltage gradient, solid: liquid ratio, and extraction time were effective. It has been observed that the improvement potential (IP) value calculated for the system decreases depending on the increasing voltage gradient. The results obtained in this study are thought to be an important data source for literature, pilot, and industrial-scale production systems. It has been realized that ohmic heating, which is increasingly used, is an alternative technique for pectin production.
AtıfScopus13WoS12OpenAlex16
İncele
MakaleYalnız künye2022Scopus SJRQ2/r/munzur/2472
The effects of different packaging methods and sous vide cooking on chemical, sensory, and microbiological changes of marinated crayfish (Astacus leptodactylus Esch., 1823)
Kurt Kaya, Gülderen
Chemical and sensory parameters and the microbiological condition of marinated crayfish (Astacus leptodactylus), with emphasis on the quality and safety parameters, in brine, vacuum packaging (VP), and sous-vide cooking were investigated. Quality assessment of crayfish stored in in brine, vacuum packaging (VP), and sous-vide (SV) for up to 120 days at 4 ± 1°C was done by the monitoring of sensory parameters, microbiological condition, pH value, total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), and peroxide value (PV). The highest concentration of TVB-N was recorded in the marinated crayfish stored under brine whereas the lowest TVB-N in the marinated crayfish stored under SV packed conditions. The concentration of TBA increased and its level reached over 5.44 mg MA/kg for crayfish stored in brine, 3.57 mg MA/kg for VP and 2.54 mg MA/kg for SV at 120 days. The formation of PV increased with the time of storage and was the lowest in the marinated crayfish stored in SV packed. During storage period, aerobic and anaerobic colony count, Escherichia coli, Coagulase positive staphylococcus, Listeria monocytogenes, Salmonella, and Clostridium perfringens were not found in any of samples. The marinated crayfish packed in sous-vide had extended shelf life at 4 ± 1°C compared to that packaged in brine and VP according to physicochemical analysis. Novelty impact statement: The biochemical quality degradation was considerably inhibited in SV-processed samples. Sous-vide packaging style had antioxidant activity. Crayfish processed by sous vide extended shelf-life to 120 days.
AtıfScopus5WoS5OpenAlex4
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MakaleAçık Erişim2022Scopus SJRQ2/r/munzur/2444
Homophobia levels of parents of nursing students and affecting factors
Beydağ, Kerime Derya; Alp Dal, Nursel
Purpose: The aim of this study is to determine the homophobia levels of parents of students who receive nursing education and the factors affecting their homophobia levels. Design and Methods: The study was carried out as a descriptive and cross-sectional study on the 375 parents of nursing students. Findings: There was statistically significant difference between the case when parents know that there is a homosexual individual in their immediate environment and the mean The Hudson and Ricketts Homophobia Scale (HRHS) score, as well as between the case when parents know that a friend of theirs is homosexual and the mean HRHS score (p < 0.05). Practice Implications: It should be taken into account that parents' prejudices against homosexuals may also affect the way their children view homosexuals.
AtıfScopus3WoS3OpenAlex3
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MakaleYalnız künye2022Scopus SJRQ2/r/munzur/2427
Investigation of the changes in rheological properties and some quality characteristics of probiotic fermented almond milk with added different ratios of orange juice
Duran, Gülseven; Cevik, Mutlu
In this study, the changes in pH, titratable acidity, survival of Lactobacillus acidophilus, mold and yeast counts, rheological properties, and sensory evaluation of fermented almond milk samples with and without added 100% orange juice at three different ratios (10%, 20%, and 30%) were investigated. pH and titratable acidity values of fermented almond milk samples varied between 3.97–4.40 and 0.178%–0.478% at the end of the fermentation process, respectively. It was determined that the survival of L. acidophilus content of fermented samples varied between 7.58 and 7.95 log CFU/ml. The best suitable rheological model for the flow behavior of all fermented almond milk samples was the Power-Law model. Fermented almond milk samples with added 20% and 30% orange juice was more preferred by the panelists. It is thought that the results of this study could provide valuable information for equipment and pumping systems that can be installed on an industrial scale. Practical applications: In recent years, cereals (oats, rice, corn), legumes (soybean, cowpea, chickpea), oilseeds (sesame, sunflower, flaxseed), and hard-shelled fruits (almond, coconut, hazelnut, peanut, walnut) is widely used in the production of plant milk. In this study, the changes in some quality and rheological properties of fermented almond milk samples with added different ratios of orange juice were investigated. It was determined that all fermented almond milk samples had high probiotic content at the end of the fermentation stage. As a result of the sensory evaluation, it was determined that the acceptability of fermented almond milk with added 20% and 30% orange juice was very high compared to other samples.
AtıfScopus2WoS2OpenAlex2
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MakaleYalnız künye2022Scopus SJRQ2/r/munzur/2426
Synthesis, characterization, pH-sensitive swelling and antimicrobial activities of chitosan–graft-poly(hydroxyethyl methacrylate) hydrogel composites for biomedical applications
Torğut, Gülben; Yazdıç, Ferit Can; Gürler, Nedim
In this paper, 2-hydroxyethyl methacrylate (HEMA) was graft copolymerized onto chitosan (CHI) at different ratios using a radical initiator. The grafted hydrogel composites were then characterized by attenuated total reflection Fourier transform ınfrared spectroscopy (ATR-FTIR) and thermo-gravimetric analysis (TGA). Swelling behavior of the hydrogels was investigated at different pH and different times. The antimicrobial activity of the chitosan-graft-HEMA (CHI-HEMA) against gram-negative bacteria and gram-positive bacteria was studied by the standard agar well diffusion assay method. The CHI-HEMA 1:1 and CHI-HEMA 1:2 showed an obvious antimicrobial effect against six test strains. The CHI-HEMA 1:1 and CHI-HEMA 1:2 exhibited a highly significant increase (p < 0.01) in diameter of the inhibition zones compared with the standard antibiotics. Furthermore, CHI-HEMA 1:1 presented the highest antimicrobial activity against all test strains with a significant difference (p < 0.01) compared with CHI-HEMA 1:2. Meanwhile, the decreasing order of the average sensitivity to CHI-HEMA 1:1 and CHI-HEMA 1:2 was observed to be S. marcescens > E. coli > S. aureus subsp. aureus > S. enteritidis > E. faecalis > E. aerogenes. These results indicate potential application of CHI-HEMA 1:1 and CHI-HEMA 1:2 graft hydrogels as a novel and efficient antimicrobial agent in biomedical fields.
AtıfScopus40WoS36
İncele
MakaleYalnız künye2022Scopus SJRQ1/r/munzur/2374
Graphene-reinforced novel poly(acetoxystyrene-co-glycidylmethacrylate) composites: Synthesis and optimization of dielectric behaviors using response surface methodology
Pihtili, Güzin
In this work, a new copolymer synthesis of Poly(acetoxystyrene-co-glycidylmethacrylate) (P[AOS-co-GMA]) by free radical polymerization (FRP) method is reported. The polymer composites (P[AOS-co-GMA]/graphene), containing different amounts of graphene, were prepared by the solution casting technique. Composites of Poly(acetoxystyrene-co-glycidylmethacrylate) loaded with 2.03 mass%, 5.00 mass%, 7.97 mass%, and 10 mass% graphene. The structure of AOS-GMA systems was characterized by fourier transform infrared, 1H-NMR and scanning electron microscopy. Thermal features were evaluated by the thermogravimetric analysis and differential scanning calorimetry. The aim of this study is to optimize the ε′ (dielectric constant) and ε′′ (dielectric loss factor) of pure polymer and graphene-doped (2.03-5-7.97-10 mass%) P(AOS-co-GMA) composite using response surface methodology. For optimization of the process and creation of the mathematical model, the central composite design package was used. The significance of the process parameters in the model was evaluated by analysis of variance (ANOVA) research. The effects of process parameters, frequency (Hz), voltage (V), and graphene ratio (mass%) on ε′ and ε′′ were examined at ambient temperature. The maximum ε″ value (8.01) was reached at around the 699 Hz frequency and at 11.43 V voltage at the graphene content of 9.82 mass%. The model estimated the maximum value of the ε′′ (0.08) when the frequency was set at 51.20, the voltage was fixed at 1.16 and the graphene content was fixed at 9.97 wt%. The ANOVA results showed that frequency and graphene content were the main model parameters and had a remarkable effect on the dielectric properties. This article presents the development of a new polymeric composite and optimize effect of process parameters, such as frequency (A), voltage (B) and amount of graphene (C).
AtıfScopus4WoS4OpenAlex4
İncele
MakaleAçık Erişim2022Scopus SJRQ2/r/munzur/2346
Comparison of nutrient contents of wild and farmed rainbow trout (Oncorhynchus mykiss, Walbaum 1792) from Keban Dam Lake in Eastern Anatolia region of Turkey
Özçiçek, Esin; Can, Erkan; Yılmaz, Ökkeş
In this study, fatty acids, fat-soluble vitamins (A, D, E, K vitamins) and cholesterol contents of wild-caught and farm-raised rainbow trout (Oncorhynchus mykiss) were compared. The amounts of docosahexaenoic acid (22:6 n-3, DHA) in wild and farmed forms were 21.56%–18.14%, 18.79%–16.21% and 14.34%–11.49% in April, May and June, respectively. Vitamin E, which is one of the fat-soluble and antioxidant vitamins, showed highest level among the vitamins. Vitamin E levels in both wild and farmed fish were 5.11–4.26, 4.83–2.89 and 0.99–1.95 mg/100 g in April, May and June, respectively. The substantial difference between wild and farmed rainbow trout was found in May (p < 0.05). In conclusion, both wild and farmed rainbow trout from Keban Dam Lake (Pertek Region) can be considered as good sources of n-3 polyunsaturated fatty acids (PUFA). However, it was observed that the n-3 PUFA level in wild form was higher than the culture fish within the investigated monthly periods. On the other hand, farmed fish demonstrated higher levels of n-6 PUFA over the wild individuals.
AtıfScopus11WoS9OpenAlex8
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MakaleYalnız künye2022Scopus SJRQ2/r/munzur/2337
Dielectric Biodegradable Biopolymer-Based Graphene Nanocomposites for Use in the Packaging Industry and Capacitor Application
Gürler, Nedim; Torğut, Gülben
In this study, polyhydroxyalkanoate (PHA) and polylactic acid (PLA)-Graphene (G) nanocomposite films were synthesized by taking different concentrations of G via the solution casting process, and their structural, mechanical, opacity, thermal and dielectric properties were examined for the first time. Scanning electron microscopy (SEM) was used for investigating surface morphology. Films containing graphene were more opaque than films without graphene. The incorporation of graphene into the polymer matrix improved the mechanical property. The tensile strengths of the control PHA/PLA film and the graphene-reinforced 1 %G-PHA/PLA nanocomposite films were 18.98 and 24.34 MPa, respectively. Thermogravimetric analysis results showed that PHA/PLA−G nanocomposites had good thermal stability below 300 °C. Considering the dielectric measurements, it is seen that the dielectric constant (έ) and dielectric loss (ϵ”) decreased with increasing frequency and less changed at higher frequencies. The developer feature of graphene is remarkable in both parameters. The electrical conductivity of PHA/PLA−G nanocomposites was also examined as a function of frequency at room temperature. As the amount of G increased from 1 %wt to 5 %wt, the conductivity of the composites increased.
AtıfScopus9WoS8OpenAlex11
İncele
MakaleYalnız künye2021Scopus SJRQ2/r/munzur/3576
Graphene-reinforced potato starch composite films: Improvement of mechanical, barrier and electrical properties
Gürler, Nedim; Torğut, Gülben
In this study, PSG composite films were prepared by casting method by adding graphene (G) to glycerol plasticized potato starch (PS) films. The structure and properties of the composite films were investigated attenuated total reflectance Fourier transform infrared (ATR-FTIR), X-ray analysis (XRD), and swelling capacity, total soluble matter, transparency, tensile strength, and electrical conductivity. When the G content of PSG composite films increased from 0% to 1%, tensile strength increased from 1.035 MPa to 1.681 MPa, but decreased to 1.175 MPa in composite films containing 2% G. It also increased electrical conductivity when the G concentration increased. Also, the G layers are among the PS films and their swelling and solubility properties are reduced. With increased G concentration, the light transmittance decreased and the films were more opaque. These improvements can refer to the interface interaction between PS and G.
AtıfScopus43WoS35OpenAlex39
İncele
MakaleAçık Erişim2021Scopus SJRQ2/r/munzur/3183
The effect of nurses' compassion on burnout: A cross-sectional study
Kaplan Serin, Emine; Özdemir, Ahmet; Işik, Kevser
Purpose: This study was carried out to determine the effect of nurses' compassion on burnout. Design and Methods: This cross-sectional descriptive study was conducted with 177 nurses. An introductory information form, the compassion scale and the Maslach burnout inventory were used as the data collection tools. Frequency, percentage, t test, analysis of variance, Kruskal-Wallis, correlation, and regression were used in the analysis of the data. Findings: The majority of the participants were determined to be female, married and university graduates. It was determined that there was a significant negative relationship between the nurses' sense of compassion and burnout levels, and burnout decreased as compassion increased. Practical Implication: Burnout and compassion fatigue may lead to inadequate care for the patient. This situation will negatively influence nurses' care quality.
AtıfScopus13WoS10OpenAlex14
İncele
MakaleAçık Erişim2021Scopus SJRQ2/r/munzur/3089
The usage of Ohmic heating in milk evaporation and evaluation of electrical conductivity and performance analysis
Ariç Sürme, Seda; Sabancı, Serdal
Ohmic heating is based on the principle of heating by passing an alternating current through the product between two electrodes and is an increasingly current electrical heating technique in food applications. The main purpose of the present study is to evaporate milk (cow's milk) from 7.85 kg-water/kg-dry matter (DM) content to approximately 3 kg-water/kg-DM content under atmospheric conditions in different voltage gradients and to examine the electrical conductivity (EC) value during the evaporation process. Also, performance evaluation was determined and compared with the traditional method. It was determined that the total process time in the Ohmic heating assisted evaporation (OHAE) process was 31–92.5 min, while in the traditional evaporation process, the total process time was 41.10 ± 2.1 min. The EC value was 0.43–1.89, 0.44–1.89, and 0.44–1.92 S/m for 7, 9, and 11 V/cm, respectively. In the OHAE process, it was determined that as the voltage gradient increased, the energy and exergy efficiency increased. The lowest energy and exergy efficiency values were obtained in the traditional method. In general, OHAE can be applied to milk, and it was a highly efficient process. Practical applications: Ohmic heating is one of the current electrical heating techniques studied in many areas by researchers. In this study, the change in electrical conductivity and performance values during the milk evaporation process was examined and compared with the traditional method. The OHAE process was more efficient than the traditional method in terms of both energy and exergy efficiency. It is thought that this evaluation will contribute as a data source for both industry and pilot-scale designs. Besides, it will contribute data to the literature with the exergy analysis that is limited in the Ohmic heating process. As a result, a concentrated milk sample with high yield and approximately 3 kg water/kg DM content was obtained.
AtıfScopus21WoS16OpenAlex20
İncele
MakaleYalnız künye2021Scopus SJRQ2/r/munzur/2847
Two Medicinal Plants (Alkanna trichophila and Convolvulus galaticus) from Turkey: Chemical Characterization and Biological Perspectives
Mahomoodally, Mohamad Fawzi; Zengin, Gokhan; Sinan, Kouadio Ibrahime; Ak, Gunes; Sadeer, Nabeelah Bibi; Angeloni, Simone; Mustafa, Ahmed M.; Caprioli, Giovanni; Maggi, Filippo; Cakilcioglu, Ugur
The aim of the present study was to quantify selected phenolic compounds, determine antioxidant activity and enzyme inhibitory effects of the aerial parts of Alkanna trichophylla Hub.-Mor. (A. trichophylla) and Convolvulus galaticus Rost.ex Choisy (C. galaticus) extracts prepared by homogenizer-assisted extraction (HAE), maceration (MAC) and infusion techniques. This is the first time such study has been designed to validate the phytochemical composition and bioactivity of these plants. Multivariate analysis was conducted on collected data. Rutin and caffeoylquinic acid derivatives were the most significant compounds in A. trichophylla and C. galaticus, respectively. The highest antioxidant activity of A. trichophylla was mostly exhibited by HAE/methanolic extracts as determined by DPPH, ABTS, FRAP (51.39, 112.70 and 145.73 mg TE/g, respectively) and phosphomolybdenum (2.05 mmol TE/g) assays. However, significant antioxidant activities varied within the extracts of C. galaticus. HAE/methanolic extract of A. trichophylla significantly depressed AChE (2.70 mg GALAE/g), BChE (5.53 mg GALAE/g) and tyrosinase (26.34 mg KAE/g) activities and that of C. galaticus inhibited AChE (2.04 mg GALAE/g), tyrosinase (31.25 mg KAE/g) and α-amylase (0.53 mmol ACAE/g) activities significantly. We concluded that HAE was the most efficient extraction technique as high yield of compounds and promising bioactivities were recorded from extracts prepared. Multivariate analysis showed that types of solvents influenced recovery of compounds and biological activities. This research study can be used as one methodological starting point for further investigation on these plants as all results are clearly promising and open the door to further research challenges such as cytotoxicity evaluation, molecular docking analysis, and more screening of pharmacological actions.
AtıfScopus12OpenAlex10
İncele
MakaleAçık Erişim2021Scopus SJRQ2/r/munzur/2753
Lycopene ameliorates propionic acid-induced autism spectrum disorders by inhibiting inflammation and oxidative stress in rats
Erten, Fusun
This study was conducted to study lycopene efficacy in brain-behavior, pro-inflammatory and apoptotic markers, and antioxidant levels in a rodent model. Rats were administered with propionic acid (PPA) (500 mg/kg BW) to induce autism-like disorders, then treated with different lycopene (L) concentrations (5, 10, 20 mg kg−1 day−1) for 35 days. The groups were: (i);control, (ii);PPA, (iii);PPA + L5, (iv);PPA + L10, and (v);PPA + L20. In this study, serum and brain malondialdehyde (MDA) levels decreased with lycopene supplements compared to the PPA group, similarly to the brain levels of inflammatory factors (IL-1α, IL-8, NF-κB, TNF-α; p <.05). Besides, brain levels of anti-apoptotic Bcl-2 decreased, whereas pro-apoptotic Bax, antioxidant Nrf2, and HO-1 levels in brain increased compared with PPA (p <.05). This study showed that lycopene might have therapeutic value to improve the dysfunctions in learning and memory in a dose-dependent way, along with the antioxidant, anti-inflammatory, and antiapoptotic molecular responses in a rat model of ASD-like disorders. Practical applications: This study suggested that lycopene can reduce propionic acid (PPA)-induced learning and memory impairment and oxidative damage by participating in multiple biological activities such as antioxidant, and anti-inflammatory effects. Lycopene protects serum and brain tissues against PPA induced oxidative damage in rats. These effects may be realized through up-regulation of the brain Nrf2/HO-1 pathway and down-regulation of the IL-1α, IL-8, TNF-α, and NF-κB levels. Lycopene may also contribute to memory and learning function, apoptotic/antiapoptotic modulation, and antioxidant and possible therapeutic efficacy in PPA-induced- Autism spectrum disorder cases.
AtıfScopus26WoS19OpenAlex26
İncele
MakaleAçık Erişim2021Scopus SJRQ2/r/munzur/2730
Preservice teachers' nomophobia levels, sense of loneliness and adjustment to college life
Çevik-Durmaz, Yadigar; Yalçinkaya-Önder, Eylem; Timur, Serkan
Purpose: The aim of this study was to investigate whether preservice teachers' nomophobia levels, sense of loneliness and adjustment to university life vary based on their demographic characteristics. Additionally, regression analyses were carried out to determine whether their sense of loneliness, nomophobia levels, and adjustment to university life were predictors of each other. Design and Methods: In this quantitative study, the cross-sectional survey research model was used. A total of 234 preservice teachers, 65 of whom were studying at the elementary mathematics department, 81 of whom were studying at the preschool education department, and 88 of whom were studying at the science education department, participated in this study. Independent-samples t test, one-way analysis of variance (ANOVA) and simple linear regression analyses were used to analyze the quantitative data. Findings: The main conclusions from this study were that (a) the students with the highest sense of loneliness were the students of the elementary mathematics department, the students with the highest level of nomophobia were the science education students, and the students who adjusted the most to university life were the preschool education students. (b) There were no significant differences between the 1st and 2nd year preservice teachers in terms of their sense of loneliness, nomophobia levels, and adjustment to university life. (c) There were statistically significant differences between the mean total nomophobia scores of the male and female students in favor of the females especially in the “losing connectedness” and “not being able to access information” subscales of nomophobia. (d) A statistically significant difference was found between the preservice teachers whose mothers were high school and university graduates in terms of their academic adjustment in favor of the preservice teachers with mothers who had university degrees. (e) The preservice teachers, who stated that their relationship with their family was very good, had higher levels of sense of loneliness, mobile phone addiction, and adjustment to university life than the others. The results were statistically significant in all total scores of the loneliness scale and dimensions except for the dimensions of nomophobia. (f) The students who were hopeful for the future had a high sense of loneliness and adjustment to university life. It was also determined that the students who were desperate for their future had high mobile phone addiction levels. Apart from nomophobia and its dimensions and the social adjustment dimension of university life, statistically significant differences were found between the hopeful and hopeless students in terms of their sense of loneliness and adjustment to university life. (g) Statistically significant mean differences were found between the students who were generally satisfied with and those that were not satisfied with their life in terms of their sense of loneliness and adjustment to university life with its all dimensions in favor of the satisfied ones. (h) The preservice teachers who lived alone at home had a higher sense of loneliness and better adjustment to university life. It was also noteworthy that the students living in dormitories had higher nomophobia levels than the others. (i) A linear relationship was found between the students' sense of loneliness and adjustment to university life, and sense of loneliness was a significant predictor of adjustment to university life. Practical Implications: Determining students' nomophobia levels, sense of loneliness, and adjustment to university life would be beneficial in bringing students who have difficulty adapting to new living environments into social life.
AtıfScopus10WoS7OpenAlex16
İncele
MakaleYalnız künye2018Scopus SJRQ3/r/munzur/3133
Curcumin ameliorates doxorubicin-induced cardiotoxicity by abrogation of inflammation, apoptosis, oxidative DNA damage, and protein oxidation in rats
Benzer, Fulya; Kandemir, Fatih Mehmet; Ozkaraca, Mustafa; Kucukler, Sefa; Caglayan, Cuneyt
Doxorubicin (DXR) is a highly effective drug for chemotherapy. However, cardiotoxicity reduces its clinical utility in humans. The present study aimed to assess the ameliorative effect of curcumin against DXR-induced cardiotoxicity in rats. Rats were subjected to oral treatment of curcumin (100 and 200 mg/kg body weight) for 7 days. Cardiotoxicity was induced by single intraperitoneal injection of DXR (40 mg/kg body weight) on the 5th day and the rats sacrificed on 8th day. Curcumin ameliorated DXR-induced lipid peroxidation, glutathione depletion, decrease in antioxidant (superoxide dismutase, catalase, and glutathione peroxidase) enzyme activities, and cardiac toxicity markers (CK-MB, LDH, and cTn-I). Curcumin also attenuated activities of Caspase-3, cyclooxygenase-2, inducible nitric oxide synthase, and levels of nuclear factor kappa-B, tumor necrosis factor-α, and interleukin-1β, and cardiac tissue damages that were induced by DXR. Moreover, curcumin decreased the expression of 8-OHdG and 3,3′-dityrosine. This study demonstrated that curcumin has a multi-cardioprotective effect due to its antioxidant, anti-inflammatory, and antiapoptotic properties.
AtıfScopus154WoS143OpenAlex163
İncele
Dergi/r/munzur/3034
Integrated Environmental Assessment and Management
İncele
Dergi/r/munzur/2992
Andrologia
İncele
Dergi/r/munzur/2881
Water and Environment Journal
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