Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Ince, Muharrem(4)
- Onal, Ali(2)
- Serdar, Osman(2)
- Yaman, Mehmet(2)
- Alişer, Ahmet Bedrettin(1)
- Asma, Dilek(1)
- Aydin, Ali(1)
- Aydin, Rahmi(1)
- Eroğlu, Mücahit(1)
- Ince, Olcay Kaplan(1)
- Kaplan Ince, Olcay(1)
- Kaplan, Olcay(1)
- Karaaslan, Nagihan M.(1)
- Kaya, Gokce(1)
- Korkmaz, Şengül Aslan(1)
- Mişe Yonar, Serpil(1)
- Pala, Aysegul(1)
- Pala, Ayşegül(1)
- Sahilli, Yeliz Cakir(1)
- Yildirim, Numan(1)
- Yonar, Muhammet Enis(1)
- Yonten, Vahap(1)
- İspir, Ünal(1)
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ2Cadmium-induced changes in haemato-immunological, oxidative stress and antioxidant parameters of Cyprinus carpio: Protective role of curcumin
Pala, Ayşegül; Eroğlu, Mücahit; Mişe Yonar, Serpil; İspir, Ünal; Yonar, Muhammet Enis
This study examined the adverse effects of sublethal concentrations of cadmium (Cd) and the potential of curcumin (CUR) to mitigate Cd-induced toxicity. We administered 1.5 and 3 mg/L of Cd and 100 mg/kg of CUR to fish (Cyprinus carpio) separately and in combination over 14 days. At the end of the experiments, various haematological and immunological parameters, oxidative stress levels and antioxidant parameters of fish were measured, and the differences between the groups were evaluated. Simultaneous CUR treatment with Cd reversed the changes in haematological parameters in fish, increased immune responses, reduced oxidative stress and normalized the impaired antioxidant enzyme activities. In summary, our study showed that dietary supplementation with CUR may be an effective strategy to reduce the toxic effects of Cd in carp.
- MakaleAçık Erişim2025Scopus SJRQ4Biochemical Responses of Zebra Mussel Dreissena polymorpha (Pallas, 1771) (Bivalvia: Dreissenidae) against Cadmium
Alişer, Ahmet Bedrettin; Aydin, Rahmi; Serdar, Osman
The biochemical reactions of zebra mussels Dreissena polymorpha (Pallas, 1771) exposed to different concentrations of cadmium (Cd) in the acute period (24 and 96 hours after treatment) were studied. Four variants of experimental treatment were examined: 0 μg/L Cd (control), 10 μg/L Cd, 20 μg/L Cd and 40 μg/L Cd. Changes in the enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) levels were determined using ELISA kits. In D. polymorpha exposed to the three experimental concentrations of cadmium, there was a statistically significant decrease (p<0.05) in SOD enzyme activity with increasing concentration or exposure times. No change was observed in CAT enzyme activity with increasing concentrations. The decrease in the activity depending on the exposure times was not statistically significant (p>0.05). As for GPx enzyme activity, a significant increase was detected after Cd application compared to the control (p<0.05). TBARS and GSH levels increased significantly in all Cd application groups compared to the control at 24 and 96 hours. The effects of different concentrations of Cd on D. polymorpha in the acute period were associated with changes in SOD, CAT, GPx enzyme activities. TBARS and GSH levels were effective parameters in determining the oxidative damage caused by Cd.
- MakaleAçık Erişim2022Scopus SJRQ1Cadmium exposure in population: alcoholic beverage consumption and health risk assessment
Kaplan Ince, Olcay; Ince, Muharrem; Onal, Ali
Risk assessment of cadmium (Cd) for human health play a key role because of toxic effect. Researchers are undergoing constant development for modelling approaches to make a risk assessment. It was carried out a central composite design combining with response surface modeling to optimize and modeling of Cd2+ ions in this study. Also, this study was performed to provide information about possible risk associated with alcoholic beverage consumption. Some independent process parameters including contact time and pH were chosen for optimization. Under optimal parameters, 142.9 mg g−1 was determined as Cd2+ ions removal effectiveness. Significance independent parameters and their interactions were checked using analysis of variance. These results were verified by correlation coefficients (R2 = 0.9967) of the statistical prediction. Estimated daily intake (EDI) and target hazard quotients (THQ) were calculated, to assess health risk. The Cd2+ ions EDI values (µg/day/person) were less than the recommended dietary allowance values and also, its THQ value was less than 1, also. When the obtained results compared with the levels set by regulatory authorities, the studied alcoholic beverages consumption do not pose a toxicological risk. Graphical abstract: [Figure not available: see fulltext.]
AtıfScopus3OpenAlex3
İncele - MakaleYalnız künye2019Scopus SJRQ4THE TOXIC EFFECT OF CADMIUM ON HUMAN ERYTHROCYTES AND NAC'S PROTECTIVE ROLE
Sahilli, Yeliz Cakir
The toxic effects cadmium (Cd), which is a heavy metal, on human erythrocytes and protective effects of N-acetyl-L-cysteine (NAC) on lipid peroxidation and antioxidant enzymes were investigated. The effects of 1, 50, 150 mu M doses of cadmium and 1mM NAC on the level of malondialdehyde (MDA) in human erythrocytes and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) enzyme activities were investigated. When the Cd was applied alone, it was found that MDA level increased in erythrocytes and SOD, CAT and GPx activities decreased. No statistically significant difference was observed when 1mM NAC administered erythrocytes were compared with the control cells. However, the beneficial effect was seen only in administration doses of Cd at the levels of I and 50 mu M and NAC was observed to have a protective effect. As a result, NAC partially reduced the toxic effect caused by Cd on erythrocytes but could not completely prevent it.
- MakaleYalnız künye2019Scopus SJRQ2Modelling cadmium bioaccumulation in Gammarus pulex by using experimental design approach
Serdar, Osman; Pala, Aysegul; Ince, Muharrem; Onal, Ali
Recently, although dynamic approaches have been used increasingly to describe metal bioaccumulation in aquatic organisms, the validation of such laboratory-derived modelling is rarely assessed under environmental conditions. The present study aims to evaluate and verify statistical and mathematical models for the bioaccumulation of cadmium (Cd) and to evaluate the suitability of Gammarus pulex as a biomonitor for Cd. To optimise Cd2+ ion bioaccumulation conditions a Box–Behnken design was used and whether G. pulex can be used as an estimated tool to assess aquatic quality was investigated. A Box–Behnken experimental design combined with response surface modelling (RSM) was employed for Cd2+ bioaccumulation in G. pulex. Independent variables including temperature, contact time and Cd2+ ion concentration significance and their interactions were tested using analysis of variance. The selected variables’ optimum values were obtained by solving the quadratic regression model along with by analysing the response surface contour plots. Based on Box–Behnken design, the applied model is significant because model F-value and R2 were obtained as 5121.49, 0.9998, respectively. Bioaccumulation of Cd amount was analysed using electrothermal atomic absorption spectrophotometer. The obtained data suggest that G. pulex can be evaluated as Cd biomonitor.
AtıfScopus3WoS3OpenAlex6İncele - MakaleYayıncıda açık erişim2019Scopus SJRQ2Evaluation of pharmacological activity of heterobimetallic coordination compounds containing n, n-bis (2-hydroxyethyl)-ethylenediamine on ht29, hela, c6 and vero cells
Aydin, Ali; Korkmaz, Şengül Aslan
The present study was conducted in order to investigate the pharmacological activities of three heterobimetallic coordination compounds: [Cd(N-bishydeten)2 ][Ni(CN)4 ] (C1), [Cu2 (N-bishydeten)2 Co(CN)6 ].3H2 O (C2), and K[Cd(N-bishydeten)Co(CN)6 ].1.5H2 O (C3) (N-bishydeten = N,N-bis(2-hydroxyethyl)-ethylenediamine). This paper describes the ability of complexes to inhibit cell growth, cell migration and human topoisomerase I and to interact with DNA/BSA; this paper also evaluates the potential mechanisms of action exhibited by these compounds via the use of powerful measurement techniques. Studies on HT29, HeLa, C6 and Vero cells revealed that each compound demonstrated significant antiproliferative activity in conjunction with regressed cell migration velocity and caused apoptotic changes in morphology. There are strong data suggesting that the mechanisms of action exhibited by these compounds are associated with their DNA/BSA binding features. The IC50 and binding constant range for the compounds are 20-180 µM and 1.2-3.2 x 104 M-1, respectively. Moreover, we observed that these compounds alter the P53-Bcl-2 ratio and inhibit the relaxation activity of human topoisomerase I. Furthermore, a correlation between the antiproliferative effects of these compounds and their cytotoxic activity was observed. In conclusion, preliminary information demonstrates that these compounds have been found to exhibit effective antiproliferative activity against cancer cell lines, indicating that they are a potent candidate for further pharmacological study.
AtıfScopus5WoS5OpenAlex3İncele - MakaleYalnız künye2016Scopus SJRQ3Optimization of Cadmium Removal from Water by Hydroxyapatite Using Experimental Design Methodology
Ince, Olcay Kaplan; Ince, Muharrem; Karaaslan, Nagihan M.; Yonten, Vahap
The presence of cadmium in water is a serious threat to the environment. The removal of cadmium using hydroxyapatite as an adsorbent was studied in an aqueous system. Hydroxyapatite was prepared to process the adsorption of cadmium from aqueous solution. Experimental design methodology and response surface methodology (RSM) with a quadratic model associated with central composite design was used to optimize the pH, initial heavy metal concentration, final volume, and adsorbent dosage for the removal of cadmium. Analysis of variance identified significant factors on each parameter. RSM indicated that a pH of 8.5, a sample volume of 166 mL, an adsorbent of dosage 0.57 g, and a contact time of 82 min were optimal for the adsorption of Cd(II). Under these conditions, the removal of Cd(II) was 895 mg g(-1).
AtıfWoS17OpenAlex15İncele - MakaleYalnız künye2012Scopus SJRQ4Use of Atomic Absorption Spectrometry in Assessment of Biomonitor Plants for Lead, Cadmium and Copper Pollution
Kaya, Gokce; Yaman, Mehmet
Eleven plant species were collected from the vicinity of lead-battery plant in the city of Gaziantep, Turkey. Lead, cadmium and copper concentrations in the soil and leaves of plants were determined by atomic absorption spectrometry. Lead, Cd and Cu concentrations in the soil samples taken from battery area were found to be in the ranges of 304 similar to 602, 0. 4 similar to 0. 44 and 31 similar to 37 mg . kg(-1), respectively. Significantly increased lead concentration up to 2 750 mg . kg(-1) was found in the leaves of Eleagnus angustifolia L. plant. The lead concentrations in the other plant leaves taken from 50 m around battery factory followed the order Ailanthus altissima > Morus sp. > Juglans regia L. > Ficus carica L. > Cydonia oblonga Miller > Prunus x domestica L. The plants, Populus nigra L., Eleagnus angustifolia L. and Salix sp. were found useful for Cd, and the plant, Eleagnus angustifolia L. for Pb, to be considered as potential biomonitor. Especially, leaves of trees and plants taken from the distance of 50 m from battery plant have relatively higher Pb concentrations. Therefore, people who and animals which live in this area and benefit from these soil and plants have vital risks.
AtıfWoS12İncele - MakaleAçık Erişim2011Scopus SJRQ2Sequential extraction of cadmium in different soil phases and plant parts from a former industrialized area
Kaplan, Olcay; Ince, Muharrem; Yaman, Mehmet
Cd concentrations in mobile phases of soil are more representative than total Cd concentration for estimating Cd bioavailability, physicochemical reactivity and mobility. In this study, selective sequential extraction procedures were used to determine Cd in different soil phases. Soil samples and plants grown in these soils were collected from a serpentine and copper-mining area in Maden-Elazig-Turkey. The extracted fractions were exchangeable/carbonate, reducible-iron/manganese oxides, oxidizable-organic matter and sulfides, and residual phases except silicates. Concentrations of Cd in soils and plant samples were determined by flame atomic absorption spectrometry and inductively coupled plasma-mass spectrometry. We found that Cd concentrations in the EDTA and NH(2)OH center dot HCl extracts are higher in most soil samples compared to the other extracts. We conclude that Cd levels in mobile phases are unexpectedly high. The observed Cd concentrations are in ranges of 0.03-3.4 mg kg(-1) for soil and 0.02-2.5 mg kg(-1) for plant parts. The percentages of cadmium up to 56% in exchangeable and carbonates fractions were observed to be significantly higher than in those values less than 2% reported in literature. This study has shown that the modified extraction method can be usefully applied to determine Cd concentrations in potentially mobile phase of soil. Furthermore, it was concluded that Brassicasea and Rumex leaves can be used as hyperaccumulator plants because their translocation factor and/or enrichment coefficient values were found to be higher than 1.0.
AtıfWoS29OpenAlex29İncele - MakaleYalnız künye2010Scopus SJRQ3RESPONSE OF ANTIOXIDANT DEFENCE SYSTEM TO CADMIUM-INDUCED TOXICITY IN WHITE ROT FUNGUS Phanerochaete chrysosporium
Yildirim, Numan; Asma, Dilek
The effect of different cadmium (Cd) concentrations (5 mu M and 500 mu M) on antioxidant enzymes including superoxide dismutase (SOD, EC 1.15.1.1), catalase (CAT, EC 1.11.1.6), glutathione reductase (OR, EC 1.8.1.7) and glutathione S-transferase (GST, EC 2.5.1.18), and glutathione levels was studied in white rot fungus Phanerochaete chrysosporium (ME446), grown in liquid medium. Exposure to 500 mu M Cd resulted in significant induction of SOD actvity. Exposure to high (500 mu M) and low concentration (5 mu M) led to a clear induction of CAT activity with respect to control group. Exposure to 5 mu M Cd increased GR activity. GST activity was induced but GSH level reduced by exposure to 5 mu M Cd.
AtıfWoS11İncele