Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Gul, Muhammet(86)
- Güler, Ömer(69)
- Akkurt, Nevzat(68)
- Baskonus, Haci Mehmet(53)
- Tekin, H.O.(52)
- Bulut, Hasan(50)
- ALMisned, Ghada(49)
- Serdar, Osman(43)
- Yucesan, Melih(43)
- Paksoy, Mehmet Yavuz(42)
- Yildirim, Numan(41)
- Zengin, Gokhan(40)
- Yildirim, Nuran Cikcikoglu(39)
- Ince, Muharrem(37)
- Kocabaş, Mehmet(37)
- Celik, Erkan(35)
- Benzer, Fulya(33)
- Sulaiman, Tukur Abdulkadir(29)
- Aslan, Naim(27)
- Can, Erkan(27)
- Kutlu, Banu(27)
- Kök, Mediha(27)
- Tanyol, Mehtap(27)
- Danabas, Durali(26)
- Kutluyer, Filiz(26)
- Özkul, İskender(26)
- Ates, Mehmet(25)
- Yildirim, Ozal(25)
- Onat, Onur(23)
- Topal, Murat(23)
- Demir, Veysel(22)
- Erten, Fusun(22)
- Guler, Omer(22)
- Say, Yakup(22)
- Yaman, Mehmet(22)
- Alataş, Mevlüt(21)
- Güler, Seval Hale(21)
- Çimen, Okay(21)
- Baykal, Duygu Sen(20)
- Mete, Suleyman(20)
Yayınlar
- MakaleYalnız künye2019Scopus SJRQ2Physical, structural, optical, and radiation shielding properties of B2O3–Gd2O3–Y2O3 glass system
Al-Hadeethi, Y.; Sayyed, M.I.; Kaewkhao, J.; Askin, A.; Raffah, Bahaaudin M.; Mkawi, E.M.; Rajaramakrishna, R.
In the current paper, glass samples were prepared from the composition xGd2O3–(30-x)Y2O3–70B2O3 (where x = 5, 10, 15, 20 and 25 mol%) via the technique of melt-quenching. Various optical parameters and inter-atomic separation were evaluated for the fabricated samples. The results showed that the inter-substitution of Y2O3 content in replacement with Gd2O3 content in the glass matrix shows structural variation in the glass. The density increases from 3.5521 to 4.1613 g/cm3 with increase in Gd2O3 content that signifies the role of Gd2O3 being a glass modifier. The transmission spectra of the glass sample show more than 85% transmittance suggesting their superior transparency in the visible region. Also, several important shielding parameters of the prepared glass system have been computationally determined via the Geant4 model and the results were compared with Phy-X/PDS database software. The results revealed that the mass attenuation factor (µ/ρ) obtained by utilizing the two different toolkits are in agreement. The transmission fraction and the half value layer parameters of the glass system indicate that the glass sample with higher Gd concentration provides a better gamma blocking ability thanks to the high atomic number of Gd.
AtıfScopus31OpenAlex29
İncele - MakaleAçık Erişim2019Scopus SJRQ2Effect of gilsonite use on storage stability of styrene-butadiene-styrene modified bitumen
Yalçın, Erkut; Çeloğlu, M. Ertuğrul; Akpolat, Mustafa; Yamaç, Özge Erdoğan; Alataş, Taner; Kök, Baha Vural; Yılmaz, Mehmet
Styrene-butadiene-styrene (SBS) polymer is one of the most preferred additives to improve performance in hot mix asphalt pavements. The storage instability, in other words, the separation of a polymer-rich phase from the bitumen-rich phase in the course of storage and transportation is one of the prevalent problems in SBS modified bitumen. The present study attempted to obtain modified bitumen at the same performance level with the SBS modified bitumen, but stable with respect to the storage stability. For this purpose, both SBS and American Gilsonite (AG) were used in modified bitumen production. It was determined that modified bitumen at the same performance level was obtained with the use of 5 % SBS or 18 % AG in bitumen modification. It was also determined that the performance levels of the modified bitumen obtained with the use of 2 % SBS + 13 % AG, 3 % SBS + 10 % AG and 4 % SBS + 6 % AG were similar. Additionally, 2 %, 3 % and 4 % SBS modified bitumen were used for the assessment of storage stability properties of the SBS modified binders. These 8 different modified bitumen samples were tested for storage stability based on the EN 13399 standard. Penetration, softening point, rotational viscometer, bending beam rheometer, and dynamic shear rheometer tests were conducted on the samples. Based on all conducted tests, it was determined that more stable binders were obtained with the use of AG and SBS in terms of storage stability compared to solely SBS modified bitumen.
AtıfScopus18WoS15OpenAlex15İncele - MakaleAçık Erişim2019Scopus SJRQ3Examining sexual functions of women before and after menopause in Turkey
Yağmur, Yurdagül; Orhan, İlksen
Background: Sexuality is an important factor that completes the lives of individuals and affects people in all age groups. Objectives: To examine the sexual functions of women before and after menopause. Methods: This cross-sectional study was conducted at the Family Health Centers in Tunceli Turkey,\ between September 2014 and February 2015. The study data were obtained using a Questionnaire and the Female Sexual Function Index. The data were analyzed by number, percentage distribution, mean, standard deviation, t-test, and using binary logistic regression analysis. Results: The mean Female Sexual Function Index score of the women was 23.8±8.0. The Female Sexual Function Index score of 59.7% of women was below the cut-off score (26.55) and was accepted indicative of sexual dysfunction. Low educational level (P < 0.01), low income (P < 0.01), and menopausal status (P < 0.0001) of the women were risk factors for sexual dysfunction. Conclusion: Prevalence of sexual dysfunction in the women was very high and they indicated no effort to seek medical care. Low educational and income level and menopausal status of the women were three factors increasing the risk of sexual dysfunction. Awareness of the society and the healthcare professionals about the issue should be increased.
AtıfScopus18WoS18OpenAlex19
İncele - MakaleYalnız künye2019Scopus SJRQ1Extensive study of newly developed highly dense transparent PbO-WO3-BaO-Na2O-B2O3 glasses for radiation shielding applications
Sayyed, M.I.; Aşkın, A.; Ali, Atif Mossad; Kumar, Ashok; Rashad, M.; Alshehri, Ali M.; Singh, Mandeep
Amorphous PbO – WO3 – BaO – Na2O – B2O3 glass system have fabricated using traditional melt quenching method. The XRD and FTIR spectra confirm the amorphous nature and the various structural properties of the glasses respectively. The various optical properties have been measured in the spectral range 400–4000 cm−1. Also, to understand the shielding ability of the fabricated glasses, we used the Geant4 model of a HPGe detector and WinXcom program to calculate the mass attenuation coefficient (MAC) at six energies between 356 and 2510 keV. In order to confirm the agreement between both methods, we used correlation theory and calculated the correlation coefficients (R2) for each sample. It is found that the R2 values are close to 1 for all samples. The MAC values at 356 keV for the prepared samples lies between 0.221 and 0.246 cm2/g. It is found that the usage of different concentration of PbO (from 50 to 70 mol%) affects the MAC values and thus the attenuation ability of the samples due to the heavier density of the PbO in comparison to B2O3. The effective atomic number results showed that Pb70B10 sample (contains 70 mol% of PbO) was higher than the other samples. Hence, Pb70B10 absorbs more photons than the rest of the prepared glasses.
AtıfScopus33OpenAlex33İncele - MakaleAçık Erişim2019Scopus SJRQ1An interval type-2 fuzzy QUALIFLEX approach to measure performance effectiveness of ballast water treatment (BWT) system on-board ship
Demirel, Hakan; Akyuz, Emre; Celik, Erkan; Alarcin, Fuat
Ballast water is of paramount importance for safe and efficient shipping operation since it provides ship’s strength and stability. The ballast water, on the other hand, poses serious marine ecological problems due to the non-indigenous species (NIS) carried in sea water. The International Maritime Organisation introduced International Convention for the Control and Management of Ships’ Ballast Water and Sediments (BWM Convention) to prevent the spread of harmful species from one region to another via ballast water. According to the convention, each ship must be equipped with a proper ballast water treatment system (BWTS). In this context, this paper is aimed at measuring the performance effectiveness of current BWTS used in ships. To achieve this purpose, a Qualitative Flexible (QUALIFLEX) method is used under interval type-2 fuzzy sets (IT2FSs) environment. While the QUALIFLEX handles all possible permutations of the alternatives for outranking, the IT2FSs deal with uncertainty this paper provides practical benefits to ship owners, ship’s safety inspectors, managers and marine environmentalists during decision-making progress of the BWTS settlement on-board ship.
AtıfScopus25OpenAlex28İncele - MakaleAçık Erişim2019Scopus SJRQ1Phytochemical characterization and bioactivities of five Apiaceae species: Natural sources for novel ingredients
Zengin, Gokhan; Mahomoodally, Mohamad Fawzi; Paksoy, Mehmet Yavuz; Picot-Allain, Carene; Glamocilja, Jasmina; Sokovic, Marina; Diuzheva, Alina; Jekő, József; Cziáky, Zoltán; Rodrigues, Maria João
Several species of the Apiaceae family have been employed in traditional cultures for their curative virtues. The present study focused on five Apiaceae species, (Falcaria vulgaris (FV), Smyrniopsis aucheri (SA), Smyrniopsis munzurdagensis (SM), Smyrnium cordifolium (SC), and Actinolema macrolema (AM)). The antioxidant, enzyme inhibitory (α-amylase, α-glucosidase, acetyl- and butyrylcholinesterase, lipase, and tyrosinase), antimicrobial, phytochemical, and cytotoxicity profiles of the methanol extracts of the selected Apiaceae species were determined. SC extract (35.68 mg gallic acid equivalent/g extract) possessed the highest phenolic content while the AM extract (56.79 mg rutin equivalent/g extract) had the highest flavonoid content. HPLC-ESI-MS (High performance liquid chromatography-electrospray tandem mass spectrometry) analyses showed presence of ferulic acid in all the five species. SC extract exhibited high radical scavenging (59.28 and 94.31 mg Trolox equivalent [TE]/g extract, DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid), respectively) and reducing activity (161.44 and 113.62 mg TE/g extract, for CUPRAC (cupric reducing antioxidant capacity) and FRAP (ferric reducing antioxidant power), respectively). SM extract exhibited the highest cholinesterase's inhibitory action (3.82 and 4.76 mg galantamine equivalent/g extract, for acetyl- and butyrylcholinesterase, respectively). The extracts showed higher inhibition against α-glucosidase (7.32-11.99 mmol acarbose equivalent [ACAE]/g extract) compared to α-amylase (0.51-0.55 mmol ACAE/g extract). SC extract was the most active (137.54 mg kojic acid equivalent/g extract) tyrosinase inhibitor and FV extract (113.75 mg Orlistat equivalent/g) the best lipase inhibitor. SM extract showed potent antibacterial effect against B. cereus (MIC (minimum inhibitory concentration) 0.180 mg/mL), P. mirabilis (MIC 0.180 mg/mL), M. flavus (MIC 0.560 mg/mL), P. aeruginosa (MIC 0.275 mg/mL), and S. typhimurium (MIC 1.500 mg/mL). FV extract (MIC 0.140 mg/mL) suppressed A. fumigatus growth. Cytotoxicity was assessed on murine macrophage (RAW 264.7), human embryonic kidney (HEK 293), and human hepatocellular carcinoma (HepG2) cell lines. FV (60.3%) and SM (57.4%) showed the highest reduction on RAW 264.7 cellular viability, whereas SM (74.1%) showed toxicity against HepG2. This study supports that the Apiaceae species could be considered as promising candidates for the development of novel pharmacophores for the management of several human ailments.
AtıfScopus51OpenAlex47İncele - MakaleYalnız künye2019Scopus SJRQ2An efficient algorithm for U-type assembly line re-balancing problem with stochastic task times
Serin, Faruk; Mete, Süleyman; Çelik, Erkan
Purpose: Changing the product characteristics and demand quantity resulting from the variability of the modern market leads to re-assigned tasks and changing the cycle time on the production line. Therefore, companies need re-balancing of their assembly line instead of balancing. The purpose of this paper is to propose an efficient algorithm approach for U-type assembly line re-balancing problem using stochastic task times. Design/methodology/approach: In this paper, a genetic algorithm is proposed to solve approach for U-type assembly line re-balancing problem using stochastic task times. Findings: The performance of the genetic algorithm is tested on a wide variety of data sets from literature. The task times are assumed normal distribution. The objective is to minimize total re-balancing cost, which consists of workstation cost, operating cost and task transposition cost. The test results show that proposed genetic algorithm approach for U-type assembly line re-balancing problem performs well in terms of minimizing total re-balancing cost. Practical implications: Demand variation is considered for stochastic U-type re balancing problem. Demand change also affects cycle time of the line. Hence, the stochastic U-type re-balancing problem under four different cycle times are analyzed to present practical case. Originality/value: As per the authors’ knowledge, it is the first time that genetic algorithm is applied to stochastic U-type re balancing problem. The large size data set is generated to analyze performance of genetic algorithm. The results of proposed algorithm are compared with ant colony optimization algorithm.
AtıfScopus19WoS17OpenAlex20İncele - Derleme MakaleAçık Erişim2019Stochastic multi-criteria decision-making: an overview to methods and applications
Celik, Erkan; Gul, Muhammet; Yucesan, Melih; Mete, Suleyman
Background: The alternatives selection problem with multi-criteria in stochastic form variables is called as stochastic multi-criteria decision-making. The stochasticity of the criteria is considered using stochastic dominance, prospect theory, and regret theory. Main text: In this paper, a total 61 papers are reviewed and analyzed based on method(s) used in stochastic multi-criteria decision-making problem, method used in stochasticity, specific objective, application area, and so on classification. All papers with respect to classification aspects are examined their real or empirical applications. Moreover, the studies are statistically investigated to present the latest trends of stochastic multi-criteria decision-making. Conclusions: This detailed review study ensures a comprehension for researchers on stochastic multi-criteria decision-making in respect of showing up-to-date literature and potential research areas to be concentrated in the future. It is observed that the stochastic multi-criteria decision-making problem has an attractive approach by researchers.
AtıfScopus19WoS15OpenAlex19İncele - MakaleAçık Erişim2019Scopus SJRQ3The effect of curcumin on lipid peroxidation and selected antioxidants in irradiated rats
Ozcelik, Mehtap; Erişir, Mine; Guler, Osman; Baykara, Murat; Kirman, Esra
The effect of irradiation on oxidants and antioxidants in selected tissues and a possible protective effect of curcumin on these indices were investigated. A total of 28 rats were divided into 3 groups; group 1 was control; group 2 was the irradiation group, saline was administered intraperiotenally (i.p.) for three days and then, 9 Gy gamma irradiation was applied; group 3 was the irradiation + curcumin group: curcumin was given i.p. for three days at 200 mg/ kg body weight and then the same dose of irradiation was applied. A significant increase in malondialdehyde (MDA) was detected in the liver, kidney, and brain tissues of the rats as a result of irradiation (P ˂ 0.01). Glutathione peroxidase (GSH-Px) activity in all the tissues (except for kidneys) decreased (P ˂ 0.01), liver SOD (superoxide dismutase) activity decreased (P ˂ 0.05), and GSH (glutathione) levels in kidney and ovary tissues (P ˂ 0.001) significantly increased. While curcumin administration returned the increased MDA levels in the kidneys and brain in result of irradiation to normal (P ˂ 0.01), it did not return the increased MDA levels in the liver tissue to normal (P ˂ 0.001) despite significantly reducing them. While decreased GSH-Px and SOD activity in the liver in result of irradiation increased with the addition of curcumin (P ˂ 0.05), increased GSH levels in the kidneys and ovaries returned to control levels (P ˂ 0.001). When MDA values were examined, it was found that the addition of curcumin protected the liver, kidneys and brain from the oxidative damage caused by irradiation.
AtıfScopus8OpenAlex9İncele - MakaleAçık Erişim2019Scopus SJRQ3Regarding some novel exponential travelling wave solutions to the Wu–Zhang system arising in nonlinear water wave model
Yel, G.; Baskonus, H.M.; Bulut, H.
In this paper, our main aim is to find the new travelling wave solutions to the Wu–Zhang system which describes dispersive long waves. Some new and important travelling wave solutions with rational and exponential function structures are successfully constructed by using the improved Bernoulli subequation function method. All the obtained solutions in this study satisfy the Wu–Zhang system. The interesting three- and two-dimensional surfaces to all the obtained solutions are plotted. We carried out all the computations and the graphics plots in this paper with aid of the Wolfram Mathematica 9.
AtıfScopus13OpenAlex18İncele - MakaleYalnız künye2019Scopus SJRQ1Lactose hydrolysis and protein fortification pose an increased risk for the formation of Maillard reaction products in UHT treated milk products
Aktağ, Işıl Gürsul; Hamzalıoğlu, Aytül; Gökmen, Vural
This study aimed to survey the content of Maillard reaction products in different UHT-treated milk products and to assess how formation of these products and lysine blockage is affected by the composition. For this purpose, different commercial UHT milks including milk (whole, semi-skimmed and skimmed), lactose-hydrolyzed, protein-fortified, lactose-hydrolyzed protein fortified and follow-on infant milks were analyzed. Among the Maillard reaction products, dicarbonyl compounds, 5-hydroxymethylfurfural, furosine, N-ε-carboxymethyllysine and N-ε-carboxyethyllysine were monitored. The results showed that fortification of UHT milks with protein and carbohydrates as well as hydrolysis of lactose promoted the Maillard reaction. Among the dicarbonyl compounds, 3-deoxyglucosone formation, which was the dominant dicarbonyl compound in milks, varied between 3.12–12.67 mg/L, 13.45–21.98 mg/L and 4.59–40.38 mg/L in lactose hydrolyzed, lactose-hydrolyzed protein-fortified and follow-on infant milks whereas it was 0.22-0.40 mg/L in milks, respectively. Similarly, 5-hydroxymethylfurfural could not be detected in milks, whereas mean 5-hydroxymethylfurfural concentration was found to be 56.3 mg/L and 31.5 mg/L in protein-fortified milks and lactose-hydrolyzed protein-fortified milks, respectively. Accordingly, % blocked lysine, furosine, N-ε-carboxymethyllysine and N-ε-carboxyethyllysine content of different UHT milks were found to be significantly higher than milks (p < 0.05). This is the first study reporting the Maillard reaction products in protein-fortified and infant milks.
AtıfScopus55WoS51OpenAlex54İncele - MakaleAçık Erişim2019Scopus SJRQ2Paenidigyamycin A, potent antiparasitic imidazole alkaloid from the ghanaian Paenibacillus sp. De2Sh
Osei, Enoch; Kwain, Samuel; Mawuli, Gilbert Tetevi; Anang, Abraham Kwabena; Owusu, Kofi Baffour-Awuah; Camas, Mustafa; Camas, Anil Sazak; Ohashi, Mitsuko; Alexandru-Crivac, Cristina-Nicoleta; Deng, Hai
A new alkaloid paenidigyamycin A (1) was obtained from the novel Ghanaian Paenibacillus sp. isolated from the mangrove rhizosphere soils of the Pterocarpus santalinoides tree growing in the wetlands of the Digya National Park, Ghana. Compound 1 was isolated on HPLC at tR = 37.0 min and its structure determined by MS, 1D, and 2D-NMR data. When tested against L. major, 1 (IC50 0.75 µM) was just as effective as amphotericin B (IC50 0.31 µM). Against L. donovani, 1 (IC50 7.02 µM) was twenty-two times less active than amphotericin B (IC50 0.32 µM), reinforcing the unique effectiveness of 1 against L. major. For T. brucei brucei, 1 (IC50 0.78 µM) was ten times more active than the laboratory standard Coptis japonica (IC50 8.20 µM). The IC50 of 9.08 µM for 1 against P. falciparum 3d7 compared to artesunate (IC50 36 nM) was not strong, but this result suggests the possibility of using the paenidigyamycin scaffold for the development of potent antimalarial drugs. Against cercariae, 1 showed high anticercaricidal activity compared to artesunate. The minimal lethal concentration (MLC) and minimal effective concentration (MEC) of the compound were 25 and 6.25 µM, respectively, while artesunate was needed in higher quantities to produce such results. However, 1 (IC50 > 100 µM) was not active against T. mobilensis.
AtıfScopus32OpenAlex32İncele - MakaleYalnız künye2019Scopus SJRQ2The effect of a glyphosate-based herbicide on acetylcholinesterase (AChE) activity, oxidative stress, and antioxidant status in freshwater amphipod: Gammarus pulex (Crustacean)
Pala, Ayşegül
This study had determined the effect of glyphosate-based herbicide (GBH) on acetylcholinesterase (AChE) enzyme activity, oxidative stress, and antioxidant status in Gammarus pulex. Firstly, the 96-h LC50 value of glyphosate on G. pulex was determined and calculated as 403 μg/L. Subsequently, the organisms were exposed to sub-lethal concentrations (10, 20, and 40 μg/L) of the determined GHB for 24 and 96 h. The samples were taken from control and GBH-treated groups at 24 and 96 h of study and analysed to determine the malondialdehyde (MDA) and reduced glutathione (GSH) levels, the AChE, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) enzyme activities. In the G. pulex exposed to GBH for 24 and 96 h, the MDA level increased significantly (p < 0.05). The GSH level, the AChE, the CAT, and the GPx activities decreased compared with the control group (p < 0.05). G. pulex exposure to GBH for 24 h showed a temporary reduction in the SOD. GBH exposure led to oxidative stress in the G. pulex as well as affected the cholinergic system of the organism. These results indicated that the parameters measured may be important indicators of herbicide contamination in G. pulex.
AtıfScopus33WoS31OpenAlex35İncele - MakaleAçık Erişim2019Scopus SJRQ2Electrical characterization of solar sensitive zinc oxide doped-amorphous carbon photodiode
Koç, Mümin Mehmet; Aslan, Naim; Erkovan, Mustafa; Aksakal, Bünyamin; Uzun, Orhan; Farooq, W. Aslam; Yakuphanoğlu, Fahrettin
A new solar-sensitive zinc oxide doped-amorphous carbon diode was fabricated using the electrochemical deposition technique. The current-voltage characteristics of the fabricated Al/ZnO-a:C/p-Si/Al diode were investigated under dark and various lighting intensities using both I-V and C-V methods. The fabricated diode was characterized by XRD, SEM-EDS, FTIR and XPS analysis. Through the analysis, it was determined that the photocurrents increased with increasing intensity of incident light. The capacitance-voltage (C-V) characteristics revealed that the capacitance of the diode depended on voltage, frequency and illumination, indicating the existence of a continuous distribution of interface states. It was found that the capacitance changed drastically with changing frequency and separation was observed in different frequencies, as identified in the reverse bias region. The ideality factor obtained was found to be higher than unity, with the average barrier height and ideality factor of the diode were found to be 0.528 ± 0.0069 eV and 5.24 ± 0.39, respectively. The newly fabricated ZnO-doped amorphous carbon (Al/ZnO-a:C/p-Si/Al) photodiode exhibited good solar sensitivity. The overall results indicated that the fabricated Al/ZnO-a:C/p-Si can be used as a solar sensitive diode in optoelectronic device applications as an alternative to graphene-based materials.
AtıfScopus41OpenAlex46İncele - MakaleYayıncıda açık erişim2019Scopus SJRQ2Evaluation of pharmacological activity of heterobimetallic coordination compounds containing n, n-bis (2-hydroxyethyl)-ethylenediamine on ht29, hela, c6 and vero cells
Aydin, Ali; Korkmaz, Şengül Aslan
The present study was conducted in order to investigate the pharmacological activities of three heterobimetallic coordination compounds: [Cd(N-bishydeten)2 ][Ni(CN)4 ] (C1), [Cu2 (N-bishydeten)2 Co(CN)6 ].3H2 O (C2), and K[Cd(N-bishydeten)Co(CN)6 ].1.5H2 O (C3) (N-bishydeten = N,N-bis(2-hydroxyethyl)-ethylenediamine). This paper describes the ability of complexes to inhibit cell growth, cell migration and human topoisomerase I and to interact with DNA/BSA; this paper also evaluates the potential mechanisms of action exhibited by these compounds via the use of powerful measurement techniques. Studies on HT29, HeLa, C6 and Vero cells revealed that each compound demonstrated significant antiproliferative activity in conjunction with regressed cell migration velocity and caused apoptotic changes in morphology. There are strong data suggesting that the mechanisms of action exhibited by these compounds are associated with their DNA/BSA binding features. The IC50 and binding constant range for the compounds are 20-180 µM and 1.2-3.2 x 104 M-1, respectively. Moreover, we observed that these compounds alter the P53-Bcl-2 ratio and inhibit the relaxation activity of human topoisomerase I. Furthermore, a correlation between the antiproliferative effects of these compounds and their cytotoxic activity was observed. In conclusion, preliminary information demonstrates that these compounds have been found to exhibit effective antiproliferative activity against cancer cell lines, indicating that they are a potent candidate for further pharmacological study.
AtıfScopus5WoS5OpenAlex3İncele - MakaleAçık Erişim2019Scopus SJRQ2Automated detection of diabetic subject using pre-trained 2D-CNN models with frequency spectrum images extracted from heart rate signals
Yildirim, Ozal; Talo, Muhammed; Ay, B.; Baloglu, Ulas Baran; Aydin, G.; Acharya, U. Rajendra
In this study, a deep-transfer learning approach is proposed for the automated diagnosis of diabetes mellitus (DM), using heart rate (HR) signals obtained from electrocardiogram (ECG) data. Recent progress in deep learning has contributed significantly to improvement in the quality of healthcare. In order for deep learning models to perform well, large datasets are required for training. However, a difficulty in the biomedical field is the lack of clinical data with expert annotation. A recent, commonly implemented technique to train deep learning models using small datasets is to transfer the weighting, developed from a large dataset, to the current model. This deep learning transfer strategy is generally employed for two-dimensional signals. Herein, the weighting of models pre-trained using two-dimensional large image data was applied to one-dimensional HR signals. The one-dimensional HR signals were then converted into frequency spectrum images, which were utilized for application to well-known pre-trained models, specifically: AlexNet, VggNet, ResNet, and DenseNet. The DenseNet pre-trained model yielded the highest classification average accuracy of 97.62%, and sensitivity of 100%, to detect DM subjects via HR signal recordings. In the future, we intend to further test this developed model by utilizing additional data along with cloud-based storage to diagnose DM via heart signal analysis.
AtıfScopus145OpenAlex152İncele - MakaleAçık Erişim2019Scopus SJRQ2Using Box–Behnken design approach to investigate benzo[a]anthracene formation in smoked cattle meat samples and its’ risk assessment
Kaplan Ince, Olcay; Ince, Muharrem
In present study, a novel approach was selected for benzo[a]anthracene determination from smoked cattle meat samples using solid phase extraction under various experimental conditions. To optimize experimental variables, a three factor, three-level Box–Behnken experimental design combining with response surface methodology and quadratic programming were employed to prevent excessive amount of benzo[a]anthracene formation in smoked meat based on different experimental parameters. The influence of some important process parameters including cooking time (10–30 min), fat ratio (5–25%) and distance to the cooking source (5–25 cm), which significantly affected the formation efficiency of benzo[a]anthracene were optimized. The analysis of variance was conducted for specifying the interactions of independent variables. The independent and the dependent variables interactions were investigated. The quadratic regression model and the response surface contour plots were used to determine optimum values for the selected variables. The results of study revealed that optimum cooking time of smoked cattle meat was determined as 24.9 min, fat ratio 7.9% and the distance to the cooking source 21.8 cm. Under optimum conditions, minimum benzo[a]anthracene was formed in meat and its amount was determined using high performance liquid chromatography-mass spectrophotometer as qualitative and quantitative. The limit of detection and limit of quantitation values were calculated as 0.4 µg kg −1 and 1.1 µg kg −1 , respectively.
AtıfScopus4WoS4OpenAlex8İncele - MakaleYalnız künye2019Scopus SJRQ3Effects of temperature and impactor nose diameter on the impact behavior of PA6 and PP thermoplastic composites
Dogan, Akar; Arman, Yusuf
In this study, the effects of temperature and impactor nose diameter on the impact behavior of woven glass-reinforced polyamide 6 (PA6) and polypropylene (PP) thermoplastic composites were investigated experimentally. Impact energies are chosen as 10, 30, 50, 70, 90, 110, 130, and 170 J. The thickness of composite materials is 4 mm. Impact tests were performed using a drop weight impact testing machine, CEAST-Fractovis Plus, and the load capacity of test machine is 22 kN. Hemispherical impactor nose diameter of 12, 7, and 20 mm were used as an impactor. The tests are conducted at room temperature (20°C and 75°C). As a result, the PP composites of the same thickness absorbed more energy than PA6 composites. The amount of absorbed energy of PP and PA6 composites decreased with temperature.
AtıfScopus7WoS6OpenAlex6İncele - MakaleYalnız künye2019Scopus SJRQ3Determination of antioxidant capacity using different acidified solvents and element contents of Allium tuncelianum: A regional and varietal study on endemic edible garlic
Karaaslan, Nagihan M.; Ince, Muharrem; Kaplan Ince, Olcay; Goksin Karaaslan, Merve
Allium tuncelianum (Tunceli garlic), an endemic and threatened plant species in the Tunceli province of Eastern Turkey, is an important native source for local people. The antioxidant activities of the acidified extracts of water, acetonitrile, methanol, and ethanol of Allium tuncelianum were investigated using five antioxidant capacity tests. The results indicated that methanol extract efficiencies of garlic samples using the ABTS, CUPRAC, and reducing power capacities were higher than the other extracts. Water extract and acetonitrile extract values were highest for total phenolic content and metal chelating activities, respectively. Moreover, the element contents such as calcium (Ca), copper (Cu), iron (Fe), potassium (K), magnesium (Mg), manganese (Mn), sodium (Na), and zinc (Zn) of Allium tuncelianum samples digested by microwave and ashing ovens were determined by flame atomic absorption spectrophotometry and the results were compared statistically. The Ca, Cu, K, Mg, and Zn concentrations using the microwave method were found to be higher than the ashing procedure. However, the Fe, Mn, and Na concentrations using the ashing method were found to be higher than those using the the microwave protocol.
AtıfScopus7WoS6OpenAlex7İncele - MakaleYalnız künye2019Scopus SJRQ1Elimination of a measurement problem: A robust prediction model for missing eigenvector value to assess earthquake induced out-of-plane failure of infill wall
Onat, Onur; Yön, Burak
One of the effective methods to assess local or global behavior of structural system is to perform shake table experiment. The biggest challenge of all experiments, either shake table or others, are missing data during the experiments due to removed instruments. This problem is arose especially during the out-of-plane tests. This problem is named as “Measurement” problem. This paper is focused on detection the measurement problem and solving this problem by using Adaptive-Network Based Neuro Inference System (ANFIS). Definition of the problem is briefly missing out-of-plane eigenvector value during the implementation of a shake table experiments on a full scale one bay one storey reinforced concrete structural system. For this aim, two shake table experiments were performed with reinforced concrete frame (RCF)and infill wall at the National Civil Engineering Laboratory (LNEC)Portugal. The out-of-plane failure of infill wall was assessed under combined bidirectional seismic load. Shake table experiments were conducted on two types of specimens. One of them is Unreinforced Brick Infill Wall (URBIF)composed of single layer 22 cm thick brick. The other is single layer 22 cm thick Infill Wall with Bed Joint Reinforcement solution (IwBJR). Both specimens were made of a single-layer brick infill wall enclosure with the RCF. Bed joint reinforcement term refers horizontal bed joint reinforcement as a strengthening technique. Shake table experiments were performed on each specimen at four stages. After third level of earthquake load, the accelerometers were removed on the wall to prevent damage to them. The removal of these instruments results in missing data. The missing eigenvector values were predicted with a robust Adaptive-Network Based Neuro Inference System (ANFIS)model to present failure mode of infill wall. The estimation quality was tested with R2, Mean Absolute Percentage Error (MAPE), Mean Square Error (MSE)and Root Mean Square Error (RMSE)among with available data. The results of the quality indicator of R2 are 0.999 for URBIF model and 0.997 for IwBJR model, respectively. Moreover, rest of the indicator results are less than %1. The proposed approach is reliable on the base of quality indicator. Moreover, this study can be used for seismic engineering to predict eigenvector values to see local behavior of infill wall and mode shape evolution to determine which mod prone for partial and total collapse of infill wall.
AtıfScopus12WoS11OpenAlex10İncele