Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Akkurt, Nevzat(15)
- Sayyed, M.I.(8)
- Askin, A.(6)
- Güler, Ömer(6)
- Yildirim, Ozal(6)
- Tekin, H.O.(5)
- Zengin, Gokhan(5)
- ALMisned, Ghada(4)
- Ak, Gunes(4)
- Aslan, Naim(4)
- Gul, Muhammet(4)
- Kök, Mediha(4)
- Lassabatere, Laurent(4)
- Paksoy, Mehmet Yavuz(4)
- Stewart, Ryan D.(4)
- Yilmaz, Deniz(4)
- Çimen, Okay(4)
- Abou Najm, Majdi R.(3)
- Ali, Shahbaz(3)
- Artuğer, Fırat(3)
- Baloglu, Ulas Baran(3)
- Bayrakdar, Cihan(3)
- Dere, Ayşegül(3)
- Di Prima, Simone(3)
- Erguven, Gokhan Onder(3)
- Ilik, E.(3)
- Karataş, Mehmet(3)
- Kavaz, E.(3)
- Kaya, Mehmet(3)
- Keserci, Ferhat(3)
- Kilic, G.(3)
- Mahomoodally, Mohamad Fawzi(3)
- Nadeem, Sohail(3)
- Rodrigues, Maria João(3)
- Serdar, Osman(3)
- Simonetti, Antonio(3)
- Talo, Muhammed(3)
- Xu, Qian(3)
- Zheng, Qiang(3)
- Çılğın, Zeynel(3)
Yayınlar
- MakaleYalnız künye2021Scopus SJRQ1The form, distribution and palaeoclimatic implications of cirques in southwest Turkey (Western Taurus)
Evans, I.S.; Çılğın, Z.; Bayrakdar, C.; Canpolat, E.
The Taurus Mountains of southwest Turkey are split into numerous separated ranges, of which eleven supported former glaciers. We describe cirques and related moraines in four new locations, as well as those in seven ranges where glaciation was previously known. This gives a complete inventory of the 85 cirques in southwest Turkey. These are comparable in size to those elsewhere, but narrower and often less developed. Lengths averaging 672 m are high relative to widths of 542 m. Overall axial gradients average 22.4°. Cirque floor altitudes are controlled largely by altitudes of the mountains above, but they also vary in relation to precipitation, in sympathy with ELAs (Equilibrium Line Altitudes) of former glaciers. In most ranges where glaciers were short (extending little beyond cirques), ELA can be predicted from mean mid-floor altitude. Our observations demonstrate lower ELAs than in previous literature. Both ELAs and cirque floors rise eastward in the west, and northward inland from the coast. This supports the importance of winds from the west and southwest, off the Mediterranean Sea, bringing LGM (Last Glacial Maximum) conditions wetter than present to mountains near the coast. Cirques face on average a little east of north, showing the effects of shade and differential solar radiation receipt.
AtıfScopus21OpenAlex31
İncele - MakaleAçık Erişim2021Scopus SJRQ1An insight into Verbascum bombyciferum extracts: Different extraction methodologies, biological abilities and chemical profiles
Angeloni, Simone; Zengin, Gokhan; Sinan, Kouadio Ibrahim; Ak, Gunes; Maggi, Filippo; Caprioli, Giovanni; Kaplan, Alevcan; Bahşi, Muammer; Çakılcıoğlu, Uğur; Bouyahya, Abdelhakim
The genus Verbascum, commonly known as "mullein", bears several species traditionally used to treat various infections, inflammations and wounds. In this study, extracts from V. bombyciferum, an endemic Verbascum species from Turkey, obtained by different solvents and extraction techniques, were investigated for their bioactive contents using spectrophotometry and high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) and evaluated for their antioxidant, as well as enzyme inhibitory potentials. While spectrophotometric determination revealed the homogenizer assisted extraction/methanolic extract to yield the highest total phenolic and flavonoid contents (41.80 ± 0.70 mg GAE/g and 39.44 ± 0.30 mg RE/g, respectively), the most significant total bioactive compounds (polyphenols) in the amount of 272.862 mg kg−1, established by HPLC-MS/MS analysis, was noted for the maceration/methanolic extract. Overall, the extracts showed varied antioxidant potency, displaying free radical scavenging ability (DPPH assay: 1.04–51.33 mg TE/g; ABTS assay: 80.04–85.60 mg TE/g), reducing power (CUPRAC: 51.48–183.26 mg TE/g; FRAP: 36.33–90.04 mg TE/g; metal chelating activity (18.48–19.80 mg EDTAE/g) and total antioxidant capacity (phosphomolybdenum assay: 0.78–1.92 mmol TE/g). However, extract of homogenizer assisted extraction/methanol exhibited the highest antioxidant activity in most assays. Only the maceration/methanolic extract inhibited all the studied enzymes (acetylcholinetserase: 2.02 ± 0.20 mg GALAE/g; butyrylcholinesterase: 4.57 ± 0.09 mg GALAE/g; tyrosinase 21.44 ± 3.41 mg KAE/g and amylase: 0.46 ± 0.01 mmol ACAE/g). This study is the first attempt to highlight the potential industrial applications of the endemic plant V. bombyciferum, as a natural source of bioactive compounds that could be considered for future development of phytopharmaceuticals, targeting specific oxidative stress-linked diseases including diabetes, skin hyperpigmentation, and neurological disorders.
AtıfScopus20OpenAlex24İncele - MakaleYalnız künye2020Scopus SJRQ2Metallic nanoparticles as X-Ray computed tomography (CT) contrast agents: A review
Aslan, Naim; Ceylan, Burhan; Koç, Mümin Mehmet; Findik, Fehim
X-ray computed tomography vastly used in both medical purposes and in the research of biological and non-biological materials/samples. Some of the medical applications performed in the clinics requires special protocols where contrast agents may be needed to enhance the contrast. Iodine based contrast agents are commonly used in such applications. Iodine based contrast agents were found hazardous to the environment and some patients has iodine in tolerance due to thyroid origin diseases. Scientists from different fields try to develop contrast agents which can be an alternative to iodine based contrast agents. Metallic nanoparticles have potential to be used as CT contrast agent since metals has high X-ray attenuation and high density. Metal nanoparticles considered as toxic to the living organisms. Covering nanoparticles with organic molecule often reduce toxicity and enhance the biocompatibility. Decoration of nanoparticles with function groups give them targeting properties where special organ and/or tissue can be targeted. Up to now, different studies illustrated the importance of the multipurpose properties of the metallic nanoparticles. In this report, we assessed the metal nanoparticles reported as X-ray computed tomography contrast agent. For the first time in the literature we listed in vivo contrast enhancement, targeted drug delivery and dual/multipurpose imaging properties of each metallic nanoparticles. Therapeutic effects of metallic nanoparticles such as photothermal therapy and magnetic hyperthermia were also addressed. A chart showing relative contrast enhancement properties of the nanoparticles were produced.
AtıfScopus127OpenAlex134İncele - MakaleYalnız künye2020Scopus SJRQ2Synthesis and modification of amine-terminated maleic anhydride‑butyl acrylate copolymer and investigation of adsorption properties for cadmium (II) ions (Cd2+)
Yilmaz, Ersen; Erenler, Fatih Mehmet; Boztuğ, Ali
In this study, a maleic anhydride‑butyl acrylate copolymer (MA-BA) was synthesized using maleic anhydride (MA) and butyl acrylate (BA) monomers. The synthesis was carried out in methyl ethyl ketone by benzoyl peroxide as the initiator at 70 °C. Secondly, the MA-BA copolymer was chemically modified with ethylenediamine and abbreviated as NH2MA-BA. The copolymer and its modified structure were analyzed spectroscopically by FT-IR, thermally by Thermo Gravimetry (TGA) and by Differential Scanning Calorimetry (DSC). Solubility tests of both structures were performed. Then, the adsorption of cadmium ions (Cd2+) by the modified copolymer (NH2MA-BA) was studied. The copolymer and its modified structure were synthesized successfully, and this was proven by their FTIR spectra. The (MA-BA) copolymer is soluble in common organic solvents but (NH2MA-BA) is not due to cross-linking. The DSC and DTA results showed that chemical modification improved the structure thermally. It was shown that the Freundlich model was the best explanation for the adsorption type in correspondence with the experimental plots, and the modified copolymer is a good candidate for Cd2+ adsorption.
AtıfScopus8WoS7OpenAlex8İncele - MakaleYalnız künye2020Scopus SJRQ1Linear, nonlinear optical and photon attenuation properties of La3+ doped tellurite glasses
Boukhris, Imed; Kebaili, Imen; Sayyed, M.I.; Askin, A.; Rammah, Y.S.
Linear and nonlinear optical features of La3+ doped tellurite glasses in the form 75TeO2–10ZnO –5Li2O –(10-x)Nb2O5 –xLa2O3: x = 0, 0.5, 1.0, 1.5, 2.0, and 2.5 in mol% (abbreviated as La0.0. La0.5, La1.0, La1.5, La2.0, and La2.5) were investigated. Also, the γ-photons attenuation parameters were tested utilizing Geant4 simulation code. Results revealed that the molar polarizability (αmolar) takes values from 8.685 × 10−24 to 7.933 × 10−24 cm3, while the molar refraction (Rmolar) changes from 21.886 to 20.219 (cm3/mol) for La0.0 to La2.5 glasses. The static dielectric constant (εstatic) varies from 6.368 to 5.191, whereas optical electronegativity (χ*) varies from 0.690 to 0.852 for La0.0-La2.5 glasses. Non-linear optical susceptibility (χ3) decreases from 5.675 × 10−12 to 2.109 × 10−12 (esu) with increment La2O3 content in the glasses, while non-linear refractive index (n2optical) decreases from 8.472 × 10−11 to 3.488 × 10−11 (esu). The radiation attenuation characteristics for the tested glasses were investigated with the help of Geant4 code. The mass attenuation coefficient (μm) was simulated between 0.284 and 2.506 MeV. The influnce of La2O3 on the shielding parameters was examined. Among the studied glasses, La2.5 posseses the highest μm values. Also, La2.5 sample has the lowest transmission fraction, which implies that more photons can be attenuated with La2.5 glass using a thin glass layer. From the transmission fraction results, we found that thick glasses are needed to attenuate gamma rays coming at high energies. At 0.511 MeV, the half value layer (HVL) value of the La0.0 glass is 1.49 cm while, at the same energy, the HVL value of the La2.5 glass is 1.44 cm.
AtıfScopus34OpenAlex35İncele - MakaleAçık Erişim2020Scopus SJRQ1Effect of trichlorfon on some haematological and biochemical changes in Cyprinus carpio: The ameliorative effect of lycopene
Mişe Yonar, Serpil; Yonar, M. Enis; Pala, Ayşegül; Sağlam, Naim; Sakin, Fatih
Trichlorfon (TCF) is an antiparasitic agent used in aquaculture to treat external parasites and it belongs to the chemical class of organophosphates. This study was conducted to investigate the ameliorating effects of lycopene on TCF-induced toxicity in carp by evaluating haematological parameters and oxidant/antioxidant status. Fish were randomly divided into seven experimental groups. These groups were arranged as follows: control (no treatment) group, corn oil group, lycopene (10 mg kg−1) group, TCF-I (11 mg L−1) group, TCF-I (11 mg L−1) plus lycopene (10 mg kg−1) group, TCF-II (22 mg L−1) group and TCF-II (22 mg L−1) plus lycopene (10 mg kg−1) group. At the end of 14 days administration, blood and tissue (liver, kidney, and gill) samples were collected. Haematological changes [red blood cell (RBC) and white blood cell (WBC) count, haemoglobin (Hb) concentration, haematocrit (Ht) level, and erythrocyte indices: mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), and mean corpuscular haemoglobin concentration (MCHC)] were determined in the blood samples, while antioxidant parameters [(malondialdehyde (MDA) and reduced glutathione (GSH) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities] were evaluated in the liver, kidney and gill samples. The results demonstrated that all the haematological parameters were significantly decreased in the TCF-I and TCF-II groups when compared to the control group. Notable increases in the tissue MDA levels were observed in the TCF-treated groups. In contrast, significant decreases were observed in the tissue SOD, CAT and GSH-Px activities and GSH levels in the TCF-I and TCF-II groups. However, simultaneous treatment with lycopene provided a marked normalisation of the haematological and oxidant/antioxidant parameters compared with the TCF-I and TCF-II groups. The findings show that dietary lycopene supplementation might be helpful in abrogation of TCF toxicity by changing haematological conditions and antioxidant status in fish.
AtıfScopus34WoS28OpenAlex31İncele - MakaleAçık Erişim2020Scopus SJRQ1Remediation of pollutants with economical importance from mining waters: Usage of Cladophora fracta
Topal, Murat; Arslan Topal, E. Is̨ıl; Öbek, Erdal
The accumulations of elements (Mo, Cu, Zn and Ni) those have both pollutant characteristics and economic importance were determined in the macroalga (green alga Cladophora fracta) exposed to mining water with the aim of presentation of the possibility of using the alga as a bioindicator of these elements. The highest element concentrations (Mo, Cu, Zn and Ni) accumulated by Cladophora fracta were determined as 2.38; 19.66; 4510.5 and 19.4 mg/kg, respectively. Bioconcentration factor values decreased in the order: Ni>Cu>Mo>Zn. The Metal Pollution Index (MPI) values calculated between 17.50 and 44.98 were used to determine the pollution degree of Cladophora fracta. As a result, it was determined that Cladophora fracta highly accumulated the elements from the mine gallery water. Therefore, Cladophora fracta was a good bioaccumulator and indicator for the remediation of the elements in mine gallery waters.
AtıfScopus8WoS4OpenAlex8İncele - MakaleYalnız künye2020Scopus SJRQ1Structural, elastic, optical and γ-ray shielding behavior of Dy3+ ions doped heavy metal incorporated borate glasses
Divina, R.; Sathiyapriya, G.; Marimuthu, K.; Askin, A.; Sayyed, M.I.
The effect of modifier ions in different basis have been analyzed through a new series of heavy metals incorporated borate based glasses 39H3BO3+30PbO+20MO+10Bi2O3 +1Dy2O3 (where M=Ca,Sr,Ba,Na and K) which are synthesized following melt quenching technique for radiation screening applications. The potentiality of glasses to withstand the penetration of fast moving neutrons is checked by various studies. Functional groups are identified through different stretching and bending modes of vibrations within the glass membrane through FTIR spectral analysis. In addition to that, other structural properties like Boron-Boron distance (dB−B), molar volume of oxygen (Vo), Oxygen Packing Density (OPD), optical basicity (Λth) and Bond density (nb) are calculated theoretically. The bonding nature (β) and nephelauxetic ratio (δ) values reveals that the glasses possess more of ionic linkages. The high density value exhibited by the Bismuth lead borate glasses indicates their capability to act as a good shielding material in reactors emitting hazardous radiation. Different moduli of elasticity (E, K, G, σ) values for the present glasses are calculated and the results reveal the enhancement in shielding performances when compared to other existing glasses and a comparative study is made on it. Optical studies are carried out and the absorption of Dy3+ions to different energy levels is observed and optical band gap (Eopt) values of the synthesized glasses are calculated along with the Urbach energy (ΔE) values. Radiation shielding properties of the produced glasses were investigated in terms of the mass attenuation coefficients (µm), transmission fraction (T), half value layer (HVL) and effective atomic number (Zeff) parameters. The results attained in the shielding study indicated that glass specimen with M = Ba exhibits enhanced shielding behavior as Ba owns high atomic number (Z) compared to other elements. Glass specimen with M = Na shows the poorest shielding characteristics due to the low Z of Na.
AtıfScopus117OpenAlex107İncele - MakaleYalnız künye2020Scopus SJRQ1Effect of BaO on lead free zinc barium tellurite glass for radiation shielding materials in nuclear application
Boonin, K.; Yasaka, P.; Limkitjaroenporn, P.; Rajaramakrishna, R.; Askin, A.; Sayyed, M.I.; Kothan, S.; Kaewkhao, J.
In this study, the zinc barium tellurite glasses (ZBaT) synthesized and inspected their radiation defensive mechanism and structural behavior. Glass composition (90-x) TeO2 - 10 ZnO - xBaO, where 25≤ x ≤ 35 (mol%) was prepared using the melt quenching technique and glass-forming pseudo-ternary diagram was discussed. Addition of BaO enhances the polarization in the present glasses there by it increases the bond length hence glass network expands resulting in volume. The mass attenuation coefficient (μm) of ZBaT glasses have been evaluated at various energies via Compton scattering technique. The results found that the μm, effective atomic number and effective electron density decrease with the increase in γ-ray energies which is in a good agreement with theoretical values attained using Geant4 and WinXCOM. At 25 mol% BaO content the glass samples show less mean free path (MFP) which were compared with other standard shield defensive materials. The obtained results reveal that the formation of non-bridging oxygens increased with higher concentration of BaO. The transmission spectra of the prepared glasses displayed optical light transparency thereby demonstrating their efficient role being transparent window when used as radiation defensive material without Pb component proving them as eco-friendly for environment.
AtıfScopus80OpenAlex83İncele - MakaleYalnız künye2020Scopus SJRQ1A thermodynamic and kinetic approach to adsorption of methyl orange from aqueous solution using a low cost activated carbon prepared from Vitis vinifera L.
Yönten, Vahap; Sanyürek, Nesrin Karaca; Kivanç, Mehmet Rıza
In this paper, thermodynamic and kinetic parameters of the Methyl Orange adsorption process on active carbon prepared from endemic Vitis vinifera L. grape seeds (AC-VVL) grown in the Tunceli-Elazığ region and % removal of dye from aqueous solutions were evaluated by using a batch system. Experiments were performed as a function of pH (2, 5, 8 and 11), temperature (15 °C, 30 °C and 45 °C) and initial concentration (100, 150, 300 and 1000 mg L−1). The mechanism and characterization of adsorption of dye was analyzed pre-adsorption (AC-VVL) and post-adsorption (AC-VVL+dye) using FTIR (Fourier Transform Infrared Spectroscopy), SEM (Scanning Electron Microscope) and Brauner Emmet and Teller (BET) analyzer. The activation energy (Ea) was determined as 24.80, 39.15, −22.40 and 61.73 kJ/mol for 100, 150, 300 and 1000 mg L−1, respectively. The Langmuir, Freundlich, Temkin and Harkins Jura isotherms were used to describe the adsorption equilibrium studies at different temperatures. The Freundlich isotherm shows better fit than other isotherms in the temperature range studied. Maximum adsorption occurred at pH 2 and was approximately 79.7 mg/g. The % Recycling Yield was found to be 20% and 9 mg/g with acetone. Thermodynamic parameters like the change in enthalpy (ΔH o), entropy (ΔS o) and Gibbs free energy (ΔG o) were evaluated and the adsorption process was found to be endothermic and spontaneous. The results show that this AC-VVL biomass is an appropriate biosorbent and has specific affinity for removal of Methyl Orange from aqueous solutions.
AtıfScopus109WoS103OpenAlex111İncele - MakaleAçık Erişim2020Scopus SJRQ2Sentiment classification within online social media using whale optimization algorithm and social impact theory based optimization
Akyol, Sinem; Alatas, Bilal
In recent years, social networks have become an important part of daily life and are becoming increasingly important. In this study, sentiment analysis or opinion mining, which is one of the most well-known social network analysis problems, is considered as an optimization problem for the first time. In the same way, for the first time, sentiment analysis is considered as a multi-objective problem. Whale Optimization Algorithm and Social Impact Theory based Optimization Algorithm, which are the current intelligent optimization algorithms, are adapted for the sentiment analysis problem. Furthermore, memory feature is integrated into Social Impact Theory based Optimization Algorithm in order to obtain effective results in this study. The obtained results from the proposed algorithms are also compared with thirty-three supervised learning algorithms within real IMDB, Polarity, and Amazon data sets. In order to evaluate the performance of the results; accuracy percentage, precision, recall, F-Measure, and MCC that are the five most commonly used measure in the literature are used. When the results are examined, it is observed that adapted metaheuristic optimization algorithms give more successful results in sentiment analysis problem.
AtıfScopus35WoS27OpenAlex43İncele - MakaleAçık Erişim2020Scopus SJRQ1Investigation of potential health risks in terms of arsenic in grapevine exposed to gallery waters of an abandoned mining area in Turkey
Topal, Murat; Arslan Topal, E. Işıl; Öbek, Erdal
In this study, potential health risks in terms of arsenic in grapevine exposed to gallery waters of an abandoned mining area in Turkey were investigated. The concentrations of arsenic were determined in roots, stems, and leaves. The translocation factors and bioconcentration factors were calculated. The highest arsenic concentration in the grapevine was determined as 539.4±27 mg/kg, for root. The arsenic concentrations in grapevine as follows: Root>Leaf>Stem. The estimated daily exposure followed an order for the male, female, and children: dermal<inhalation<ingestion<dietary. The non-carcinogenic and total hazard index values calculated for As were higher than 1. The risk of arsenic to be carcinogenic has been determined. The highest carcinogenic risk can be listed as dietary > ingestion > inhalation > dermal. In our study, calculated carcinogenic risk values in terms of dietary, inhalation, and ingestion are higher than 10−4-10−6. As a result, the highest cancer risk on human health was determined as a dietary intake of grapevine leaves according to the calculated carcinogenic risk values.
AtıfScopus20WoS19OpenAlex21İncele - MakaleAçık Erişim2020Scopus SJRQ1Automated invasive ductal carcinoma detection based using deep transfer learning with whole-slide images
Celik, Yusuf; Talo, Muhammed; Yildirim, Ozal; Karabatak, Murat; Acharya, U Rajendra
Advances in artificial intelligence technologies have made it possible to obtain more accurate and reliable results using digital images. Due to the advances in digital histopathological images obtained using whole slide image (WSI) scanners, automated analysis of digital images by computer support systems has become interesting. In particular, deep learning architectures, are one of the preferred approaches in the analysis of digital histopathology images. The deeper networks trained on large amounts of image data are adapted for different tasks using transfer learning technique. In this study, automated detection of invasive ductal carcinoma (IDC), which is the most common subtype of breast cancers, is proposed using deep transfer learning technique. We have used deep learning pre-trained models, ResNet-50 and DenseNet-161 for the IDC detection task. The public histopathology dataset containing 277,524 image patches were used in our experimental studies. As a result of training on the last layers of pre-trained deep networks, DenseNet-161 model has yielded F-sore of 92.38% and balanced accuracy value of 91.57%. Similarly, we have obtained F-score of 94.11% and balanced accuracy value of 90.96% using ResNet-50 architecture. In addition, our developed model is validated using the publicly available BreakHis breast cancer dataset and obtained promising results in classifying magnification independent histopathology images into benign and malignant classes. Our developed system obtained the highest classification performance as compared to the state-of-art techniques and is ready to be tested with more diverse huge databases.
AtıfScopus297OpenAlex318İncele - MakaleYalnız künye2020Scopus SJRQ1Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study
Zengin, Gokhan; Sinan, Kouadio Ibrahime; Ak, Gunes; Mahomoodally, Mohamad Fawzi; Paksoy, Mehmet Yavuz; Picot-Allain, Carene; Glamocilja, Jasmina; Sokovic, Marina; Jekő, József; Cziáky, Zoltán
Several Apiaceae species, used as both food and in complementary and alternative medicine, represents a rich source of potential valuable phytopharmaceuticals which necessitates scientific contemplation. In the present study, the antioxidant, enzyme inhibitory, antimicrobial, and cytotoxic properties of methanol extracts of seven Apiaceae species, (Chaerophyllum macrospermum (Willd. ex Spreng.) Fisch. & C.A.Mey. ex Hohen, Ferula rigidula Fisch. ex DC., Ferula orientalis L., Prangos ferulacea Lindl., Prangos peucedanifolia Fenzl., Ferulago setifolia K. Koch, and Pimpinella anthriscoides Boiss.) were evaluated. Species belonging to the Prangos genus exhibited the highest total phenolic content, namely P. peucedanifolia and P. ferulacea, with values of 47.90 and 44.44 mg gallic acid equivalent/g extract, respectively. P. peucedanifolia also displayed the highest radical scavenging capacity (81.53 and 102.70 mg Trolox equivalent [TE]/g extract for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), respectively) and reducing power (165.87 and 100.09 mg TE/g extract for cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP), respectively). C. macrospermum showed the most potent inhibition against Alzheimer's disease related enzymes, namely acetylcholinesterase (4.53 mg galantamine equivalent [GALAE]/g extract) and butyrylcholinesterase (3.22 mg GALAE/g extract). P. ferulacea (131.94 mg kojic acid (KAE) equivalent/g extract) and P. peucedanifolia (4.97 mmol acarbose equivalent (ACAE)/g extract) were potent inhibitors of tyrosinase and α-glucosidase, respectively. In general, studied species were able to reduce cellular viabilities. P. peucedanifolia possessed promising antibacterial potential against Bacillus cereus (Minimum inhibition concentration (MIC): 0.37 mg/mL), L. monocytogenes (MIC: 0.56 mg/mL), P. aeruginosa and Escherichia coli (MIC: 0.27 mg/mL), Salmonella typhimurium and Enterobacter cloacae (MIC: 0.75 mg/mL). F. rigidula showed the highest antifungal effect against Aspergillus ochraceus and Trichoderma viride (MIC: 0.10 mg/mL). The present findings could be the scientific starting point towards the pharmaceutical and/or commercial utilization of these Apiaceae species.
AtıfScopus65OpenAlex64İncele - MakaleYalnız künye2020Scopus SJRQ1Comparative effects of Cu (60–80 nm) and CuO (40 nm) nanoparticles in Artemia salina: Accumulation, elimination and oxidative stress
Cimen, Isil Canan Cicek; Danabas, Durali; Ates, Mehmet
In this study, nanotoxicity tests were made by exposure of Artemia salina to copper (Cu 60–80 nm) and copper oxide (CuO 40 nm) nanoparticles (NPs) at different concentrations (0.2, 1, 5, 10, 25, and 50 mg/l) during some exposure duration. Characterization of Cu and CuO NPs were performed using Transmission Electron Microscope (TEM), Dynamic Light Scattering (DLS), Zeta Potential, X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Fourier Transformation Infrared (FT-IR) analyzes. In organisms, the accumulation and elimination rates of NPs was determined by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) analysis and the oxidative stress effects on A. salina were determined by Glutathione (GSH) and Thiobarbituric acid reactive substances (TBARS) analysis methods. Both NPs were found to differ in accumulation and elimination rates at each application time and in parallel with the increase in concentration. In each group, it was determined that ion release increased with application time. The results showed that the accumulation rates in Cu NPs had a tendency to increase at 48 h and to decrease at 72 h in concentrations of 0, 2 and 1 mg/l, respectively. And in the all other concentrations have been seen an increasing trend within the time. In the CuO NPs (40 nm), accumulation rates were a decrease trend at 48th hour and an increase trend at 72nd hour except 10 mg/l concentration. In the 10 mg/l group was an increase trend with the application period. Cu NP, TBARS value increased with increasing concentrations and the highest increase was observed at 24 h of 5 ppm group. The groups showed a tendency to increase-decrease-increase-decrease in TBARS levels in terms of elapsed time (24th, 48th, 72nd hour and elimination) (5 ppm and 10 ppm groups tended to decrease in TBARS level at 72nd hour). TBARS increased with increasing concentration ratios in CuO NPs (40 nm).
AtıfScopus32WoS27OpenAlex34
İncele - MakaleYalnız künye2020Scopus SJRQ1Effects of Zn and ZnO Nanoparticles on Artemia salina and Daphnia magna Organisms: Toxicity, Accumulation and Elimination
Danabas, Durali; Ates, Mehmet; Ertit Tastan, Burcu; Cicek Cimen, Isil Canan; Unal, Ilkay; Aksu, Onder; Kutlu, Banu
In the study, Zn in the size of 40–60 nm and 80–100 nm and ZnO in the size of 10–30 nm were applied to A. salina and D. magna individuals in 7 groups with 3 repetitions. Measurements were made at 24th, 48th and 72nd hours and elimination values were examined at +24 h. LC50 values of NPs were determined and chemical analysis (metal accumulation and elimination), ion quantities which were given to the environment and the survival rates of organisms were determined after the exposure. According to the results of phase contrast microscopy, it was found that both experimental organisms absorbed the NPs in the medium level. In the toxicity results of D. magna, it can be said that Zn NP (40–60 nm) has a highly toxic effect only at 50 ppm concentration for 48 h and lethal dose can be accepted as of 5 ppm at the end of 72 h. In A. salina individuals, it is clearly seen that there is an increase in mortality in organisms parallel to the dose increase. Although all NPs were applied to organisms in low doses corresponding to environmental values, it was observed that toxic effect was in parallel with the increase in time. It is clearly known that there is the inverse proportion between the size of NPs and the toxic effect. The smaller the size of NPs is, the higher the toxic effect becomes When the results of Zn accumulation and elimination of A. salina and D. magna individuals exposed to the Zn and ZnO NPs were examined; it was found that accumulation and elimination occurred in parallel with the increase in concentration at each application hour and elimination. Intensive and possible misuse of nanoscale materials is one of the biggest threats to the environment and all living things worldwide.
AtıfScopus63WoS59OpenAlex71İncele - MakaleYalnız künye2019Scopus SJRQ1Classification of myocardial infarction with multi-lead ECG signals and deep CNN
Baloglu, Ulas Baran; Talo, Muhammed; Yildirim, Ozal; Tan, Ru San; Acharya, U Rajendra
Myocardial infarction (MI), commonly known as heart attack, causes irreversible damage to heart muscles and even leads to death. Rapid and accurate diagnosis of MI is critical to avoid death. Blood tests and electrocardiogram (ECG) signals are used to diagnose acute MI. However, for an increase in blood enzyme values, a certain time must pass after the attack. This time lag may delay MI diagnosis. Hence, ECG diagnosis is still very important. Manual ECG interpretation requires expertise and is prone to inter-observer variability. Therefore, computer aided diagnosis may be useful in automatic detection of MI on ECG. In this study, a deep learning model with an end-to-end structure on the standard 12-lead ECG signal for the diagnosis of MI is proposed. For this purpose, the most commonly used technique, convolutional neural network (CNN) is used. Our trained CNN model with the proposed architecture yielded impressive accuracy and sensitivity performance over 99.00% for MI diagnosis on all ECG lead signals. Thus, the proposed model has the potential to provide high performance on MI detection which can be used in wearable technologies and intensive care units.
AtıfScopus457OpenAlex476İncele - MakaleYalnız künye2019Scopus SJRQ2Comprehensive study on the structural, optical, physical and gamma photon shielding features of B2O3-Bi2O3-PbO-TiO2 glasses using WinXCOM and Geant4 code
Sayyed, M.I.; El-Mesady, I.A.; Abouhaswa, A.S.; Askin, A.; Rammah, Y.S.
Glass samples of titanium-lead bismuth borate with the composition of (60B2O3 – 20Bi2O3 – (20-x)PbO – xTiO2), where 0 ≤ x ≤ 10 wt% labeled as BBPT0.0 (x = 0) to BBPT10.0 (x = 10) were synthesized. The melt quenching technique was used in the preparation. The amorphous character and vibrational groups for all samples were confirmed through XRD and FTIR measurements, respectively. The optical band gap (Eopt), Urbach's energy (Eurbach), and the optical dispersion constants have been determined using UV–Vis spectra. Results reveal that the values of the optical band gap energy exhibit a decrease with the TiO2 concentration, in contrast with Urbach's energy which displays a linear increase from 0.43 to 0.64 eV. In addition, the values of single-oscillator energy (Eo) has the same behavior of the optical energy gap (Eopt), while the dispersion energy parameter (Ed) has an inversely behavior. Mass attenuation coefficients (μ/ρ) of the investigated glasses have been computed using the Geant4 simulation toolkit and WinXCOM database software. Geant4 model of a HPGe detector has been employed to perform the Monte Carlo simulations for the glass samples with five thicknesses from 1 to 3 cm at the gamma ray energies in the range of 356–2510 keV. The transmission fractions as a function of the thickness at 356 keV photon energy for all studied glasses has been performed. Half value layer (HVL) was derived from the μ/ρ values. Results showed the studied glasses have good shielding capability according to their mass attenuation coefficients, transmission fractions and HVL values.
AtıfScopus140WoS136OpenAlex144İncele - MakaleYalnız künye2019Scopus SJRQ1A decision-support system based on Pythagorean fuzzy VIKOR for occupational risk assessment of a natural gas pipeline construction
Mete, Suleyman; Serin, Faruk; Oz, Nurdan Ece; Gul, Muhammet
Natural gas pipeline construction projects are major projects between countries that include onshore and offshore sections. Aim of these projects is to supply the natural gas from one place to another. Safety of workplace, environment and employers is also another important argument. In this respect, it is essential to conduct an occupational risk assessment (ORA) study to eliminate the risks that may arise around the pipeline. Application of multi-criteria decision analysis (MCDA) methods for the ORA has shown great increase recently. Also, developing a decision support system (DSS) which is easy to use and capable of extracting results enables decision makers to assess health and safety risks. Therefore, (i) A DSS based on Pythagorean fuzzy VIKOR (PFVIKOR) in ORA literature is developed for the first time; (ii) A case study is employed to risk assessment for trenchless crossings installation by auger boring process of the pipeline project; (iii) A sensitivity analysis is performed in the results of PFVIKOR-based DSS; and (iv) Two additional risk parameters called sensitivity to PPE non-utilization and undetectability are considered in ORA process apart from the classical risk assessment parameters of severity and probability. Developing such a DSS and applying it for risk assessment in a natural gas pipeline construction will contribute stakeholders in the energy industry.
AtıfScopus89WoS67OpenAlex83İncele - MakaleYalnız künye2019Scopus SJRQ2Synthesis, characterization and spectroscopic investigation of N-(2-acetylbenzofuran-3-yl)acrylamide monomer: Molecular structure, HOMO–LUMO study, TD-DFT and MEP analysis
Barim, E.; Akman, F.
In this study, a novel acrylamide monomer was synthesized and characterized by UV-Vis, FT-IR and 1H NMR measurements. The acrylamide monomer namely, N-(2-acetyl-benzofuran-3-yl)acrylamide (NABA), was prepared in two steps. In the first step, 1-(3-aminobenzofuran-2-yl)ethan-1-one was synthesized by the reaction of 1-chloroacetone with 2-hydroxy-benzonitrile under basic conditions. In the second step, the obtained 1-(3-aminobenzofuran-2-yl)ethan-1-one was reacted with acryloyl chloride and triethylamine at 0–5 °C temperature for obtaining NABA monomer. Then, the structural, vibrational, nuclear magnetic resonance and electronic properties for the synthesized monomer were determined by quantum chemical calculations of DFT method. The results were compared with experimental FT-IR, 1H NMR and UV–Vis spectral data. The band gap of HOMO and LUMO show that the NABA monomer is chemically active and has charge transfer within the monomer. Moreover, molecular electrostatic potential (MEP) maps were drawn to identify reactive regions of NABA monomer.
AtıfScopus104OpenAlex107İncele