Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Gul, Muhammet(27)
- Celik, Erkan(14)
- Mete, Suleyman(10)
- Serin, Faruk(10)
- Yucesan, Melih(10)
- Serdar, Osman(9)
- Mahomoodally, Mohamad Fawzi(7)
- Zengin, Gokhan(7)
- Aslan, Alper(6)
- Onat, Onur(6)
- Topal, Murat(6)
- Yildirim, Numan(6)
- Ak, Gunes(5)
- Akkurt, Nevzat(5)
- Alataş, Mevlüt(5)
- Batan, Nevzat(5)
- Cevik, Mutlu(5)
- Erten, Fusun(5)
- Icier, Filiz(5)
- Yildirim, Nuran Cikcikoglu(5)
- Yön, Burak(5)
- Aksakal, B.(4)
- Angeloni, Simone(4)
- Aslan, N.(4)
- Cakilcioglu, Ugur(4)
- Caprioli, Giovanni(4)
- Erata, Hüseyin(4)
- Etli, Serkan(4)
- Gürler, Nedim(4)
- Ince, Muharrem(4)
- Işık, Erdem(4)
- Kaplan Serin, Emine(4)
- Kizilkoca, Mustafa(4)
- Kutlu, Banu(4)
- Maggi, Filippo(4)
- Orhan, Cemal(4)
- Paksoy, Mehmet Yavuz(4)
- Pıhtılı, Güzin(4)
- Sahin, Kazim(4)
- Sançar, Taylan(4)
Yayınlar
- MakaleAçık Erişim2021Scopus SJRQ2Statistical evaluation of chromosomes of some Lathyrus L. taxa from Turkey
Genç, Hasan; Yildirim, Bekir; Açar, Mikail; Çetin, Tolga
In this study, a statistical analysis was performed on mitotic metaphase chromosomes of 26 Lathyrus taxa, four of which are endemic. ANOVA, correlation analysis, PCA and cluster analysis were performed to determine the relationships between taxa based on chromosomal criteria. The morphological similarities of plant taxa and chromosomal statistics results may not be always parallel to each other. According to the findings obtained as a result of analysis, the following taxa, which are close to each other were determined: L. hirsutus-L. odoratus, L. brachypterus var. haussknechtii-L. phaselitanus, L. stenophyllus-L. chloranthus, L. gorgoni var. gorgoni-L. nissolia-L. pratensis, L. tuberosus-L. annuus.
AtıfScopus5WoS4OpenAlex2
İncele - MakaleAçık Erişim2021Scopus SJRQ3Influence of cross-section geometry on air demand ratio in high-head conduits with a radial gate
Aydin, Alp Bugra; Baylar, Ahmet; Ozkan, Fahri; Tuna, Muhammed Cihat; Ozturk, Mualla
When the gate of a high-head conduit is partly opened, negative pressure draws the air in through the air vent. Air that is entrained into the water is instantly forced downstream in the form of air bubbles. When studies on high-head gated conduits were examined, it was determined that the air demand ratio varied depending on many hydraulic and geometric parameters. This work has focused on determining the effect of conduit cross-section geometry on the air-demand ratio. A series of experiments were carried out on high-head radial gated conduits having different cross-section geometries. Experimental results showed that conduit cross-section geometry had an important effect on the air demand ratio especially in small gate opening rates. Further, design equations for the air demand ratio are presented relating the air demand ratio to Froude number, gate opening rate, and the ratio of gate opening to conduit length.
AtıfScopus7WoS8OpenAlex10İncele - MakaleAçık Erişim2021Scopus SJRQ1Teachers' views related the middle school curriculum for distance education during the COVID-19 pandemic
Aslan, Seda Akti; Turgut, Yigit Emrah; Aslan, Alper
This qualitative study aims to examine teachers’ opinions concerning the middle school curricula that have been in use for years, in order to determine its suitability for distance education during the COVID-19 pandemic. The participants consisted of eighteen middle school teachers from different subject areas in Turkey. A maximum variation sampling method was employed for participant selection. The data was collected through semi-structured interviews. Due to the pandemic, the interviews were conducted using video conferencing applications. The data was analyzed through content analysis. According to the findings, the teachers report that while they are effective in achieving cognitive objectives, they have difficulties in achieving affective and psychomotor objectives. In addition, the teachers do not prefer to design their own materials, rather they mainly benefit from ready-to-use materials during emergency distance education. The teachers also reveal that direct instruction and questioning were the teaching methods and techniques they preferred in online courses and that they were unable to adapt other methods and techniques to distance education, which resulted in students experiencing teacher-centered activities. Moreover, the teachers complain about students not attending the online courses on time or even at all, their disinterest, a lack of instant feedback, limited communication with students, and insufficient course lengths. Another critical finding was that the teachers only use homework, end-of-unit quizzes, and participation to online courses as measurement and evaluation tools and agree that they are unable to administer reliable and valid evaluation tools. The limitations of the study and implications for future research are later discussed.
AtıfScopus18WoS16OpenAlex40
İncele - MakaleYalnız künye2021Scopus SJRQ1Performance of marble powder on cementitious composites including waste steel chips as an additive
Gülmez, Nihan
The reuse of industrial waste materials in cement-based composites contributed to preventing increasing environmental problems and reducing production costs. This article examined the effectiveness of using recycled steel chips (Ast) from metal industry waste and waste marble powder (BMP) instead of cement and the possibility of obtaining eco-efficient specimen. While steel chips included in mortars as additives decreased workability, marble powder increased it. An increment in the level of substitution of steel chips resulted in a subsequent increase in water absorption percentages and apparent porosities of mortars. Maximum flexural strength was obtained in 2% steel chips-10% marble powder in waste system.
AtıfScopus16WoS15OpenAlex21İncele - MakaleAçık Erişim2021Scopus SJRQ2An ethnoveterinary study on plants used for the treatment of livestock diseases in the province of Giresun (Turkey)
Güler, Osman; Polat, Rıdvan; Karaköse, Mustafa; Çakılcıoğlu, Uğur; Akbulut, Sefa
The lack of ethnoveterinary surveys in Turkey, results in losses in the veterinary phytopharmacology field. This is the first ethnoveterinary research in which statistical calculations about plants are done by informant consensus factor (ICF) method in the Blacksea Region of Turkey. To catalog, analyze, and disseminate the knowledge of plant use in ethnoveterinary practices in the province of Giresun (Turkey). Information was gathered through open and semi-structured interviews with local people, mainly elderly shepherds and farmers, in the Giresun province. The collected data was analyzed quantitatively using two indices, informant consensus factor (ICF). A total of 65 ethnoveterinary plants belonging to 38 families are used for the treatment of animal diseases. According to the local farmers, the most often mentioned species that used in the resarch area have high ethno-veterinary potential. Most of these plants are also used for some human conditions in the study area. There are large numbers of ethno-veterinary practices EVPs in southern Turkey with undocumented cumulative knowledge of the indigenous people. Unfortunately, some evidence of their slow disappearance has been found. The traditional knowledge in the treatment of livestock diseases of the Giresun districts needs further scientific evaluations by phytochemical and antimicrobial experimentation.
AtıfScopus65WoS54OpenAlex57İncele - MakaleAçık Erişim2021The antioxidant and antimicrobial capacities of phenolic profiles of some Salvia L. Seeds grown in Turkey
Emre, Irfan; Kursat, Murat; Kirbag, Sevda; Erecevit, Pinar; Emre, Mustafa Yunus; Yilmaz, Okkes; Civelek, Semsettin
The aim of current study is to show phenolics, antioxidant capacities and antimicrobial activities of seeds of five Salvia L. (S. frigida Boiss., S. candidissima subsp. candidissima Vahl., S. virgata Jacq., S. verticillata L. var. verticillata and S. russellii Benth.) taxa grown in Turkey. The flavonoid and phenolic acid contents were measured by using HPLC whilst the antioxidant capacities were determined by using different methods. In addition, agar well diffusion method was used to determine the antimicrobial activities of Salvia species in this study. It was found that S. frigida, S. verticillata var. verticillata and S. russellii have the highest catechin contents and S. frigida and S. verticillata var. verticillata have high rosmarinic acid while S. frigida, S. candidissima subsp. candidissima and S. verticillata var. verticillata have high vanilic acid. Also, it was determined that S. frigida and S. verticillata var. verticillata have high DPPH radical scavenging activities in 150 and 250 µL while S. frigida and S. verticillata var. verticillata have highest ABTS radical scavenging activity in all concentrations apart from 25 µL for S. frigida. Furthermore, S. frigida and S. verticillata var. verticillata have high total phenolic contents. On the other hand, Salvia species have similar lipid peroxidation inhibitions. However, the metal chelating activities of Salvia species are different. And also, it was demonstrated that Salvia taxa have antimicrobial activity.
AtıfScopus7OpenAlex7TR Dizin2
İncele - MakaleYalnız künye2021Scopus SJRQ2Determination of Optimum Process Conditions by Central Composite Design Method and Examination of Leaching Kinetics of Smithsonite Ore Using Nitric Acid Solution
Tanaydın, Mehmet Kayra; Bakıcı Tanaydın, Zümra; Demirkıran, Nizamettin
The leaching behavior of Tunceli smithsonite ore in nitric acid was evaluated in two study steps including optimization of leaching process and kinetics modeling. The individual and synergistic effects of effective parameters such as nitric acid concentration, solid-to-liquid ratio, stirring speed, and temperature on the dissolution rate of zinc were investigated using central composite design. Four factors including temperature (30–50 °C), nitric acid concentration (0.2–0.5 mol/L), stirring speed (350–600 rpm), and solid-to-liquid ratio (0.004–0.01 g/L) were investigated. The dissolution percent of zinc (97%) was obtained in 120 min of leaching time: acid concentration 0.5 mol/L, temperature 50 °C, stirring speed 500 rpm, and solid–liquid ratio 2/500 g/mL at the optimum conditions obtained using the central composite design. The dissolution kinetics of smithsonite was examined according to heterogenous models and it was found that the dissolution rate was controlled by ash layer diffusion process. It was found that the leaching rate increased with increasing temperature, stirring speed, and acid concentration as well as decrescent particle size and solid/liquid ratio. The trial data were analyzed by statistical and graphical methods and the activation energy of this leaching process was determined to be 28.63 kJ·mol−1. Graphical Abstract: [Figure not available: see fulltext.].
AtıfScopus9WoS9OpenAlex10İncele - MakaleYalnız künye2021Scopus SJRQ1Relationship of knowledge about and attitudes towards violence with recognition of violence against women among health staff in pre-hospital emergency medical services
Gümüşsoy, Süreyya; Dönmez, Sevgül; Ekşi, Ali; Dal, Nursel Alp
Background: Domestic violence, specifically, violence against women, is prevalent in all segments of society regardless of social class, ethnicity, culture or country. In other words, domestic violence is a global concern. Aim: The study aims to investigate the relationship between the attitude and knowledge of the health staff in pre-hospital emergency medical services about violence against women and their recognition of such form of violence. Methods: This descriptive study was conducted on 1023 paramedics and emergency medicine technicians who work in the pre-hospital emergency health setting and are members of the Paramedic and Pre-hospital Emergency Medicine Association. The Attitudes towards Violence against Women Scale (ATVAWS) and Health Staff's Recognition of Signs of Violence against Women Scale (HPRSVAWS) were used for data collection. Results: The mean scores for the ATVAWS and HPRSVAWS were 46.68 ± 6.92 and 20.31 ± 3.23, respectively. Of the participants, 48.5% had been subjected to violence, 43.93% had been subjected to violence perpetrated by their mothers, 41.53% had been exposed to physical violence and 4.2% remain exposed to domestic violence. Participants who had been exposed and those who remain exposed to domestic violence produced high scores in ATVAWS, which indicates an improvement in the traditional approach (less opposing view) to violence. High scores in the ATVAWS for (a) those who were exposed to violence in their workplaces, (b) who had never attended to actual or suspected cases of violence against women in their professional life, (c) who had attended to seven or more cases of violence against women, (d) who were less competent in physically examining actual or suspected cases of violence and (e) who had not been trained on violence against women, which indicates an increase in the traditional approach to violence. Conclusion: The study found that health staff in emergency health stations better recognised the signs of violence against women as their attitudes towards violence were less similar to the traditional approach. That is, they mostly held non-violent views. The characteristics, attitudes, perceptions and values of health professionals were considered important factors in addressing violence.
AtıfScopus7WoS4OpenAlex10İncele - MakaleAçık Erişim2021Scopus SJRQ1Highly Efficient Defluoridation of Water through Reusable poly(aniline-co-o-aminophenol) Copolymer Modified Electrode Using Electrochemical Quartz Crystal Microbalance
Unal, Asuman; Hillman, A. Robert; Ryder, Karl S.; Cihangir, Salih
Although the World Health Organization (WHO) recommends a limit of 1.5 mg l-1 fluoride ions in drinking water, this is not satisfied in many parts of the world. When this limit is exceeded, the electrochemically switched ion-exchange (ESIX) technique (mainly based on conductive polymers) has been identified as a promising method for removing the excess fluoride ions. The present study aimed to develop an efficient method based on the ESIX technique by using poly(aniline-co-o-aminophenol) copolymer to extract fluoride ions. Electrochemical quartz crystal microbalance (EQCM) and acoustic admittance data were utilized to assay the synthetic efficiency of copolymer deposition, and to evaluate the dependence of the defluoridation process on the proportions of the monomers in the copolymer matrix and on film thickness. The resulting films were characterised by Fourier transform infrared spectroscopy (FTIR) and scanning electrochemical microscopy (SEM) techniques. For optimized co-monomer ratio in the feedstock, poly(aniline-co-o-aminophenol) at an applied potential of 0.30 V showed excellent performance for fluoride removal from water at pH 6.6, to the extent of 20 (mg F-) (g polymer)-1. Comparison of the performance of ESIX using poly(aniline-co-o-aminophenol) with that of other techniques and materials reveal that it has significant potential for water defluoridation.
AtıfScopus9WoS8OpenAlex10İncele - MakaleYalnız künye2021Scopus SJRQ1Crack failure in hydrodynamically lubricated bearings: A case study hydraulic turbine
Taşgın, Yahya; Kahraman, Gökhan
This study investigates the trunnion crack of a 50 MW hydraulic turbine in the generator guide bearing. The crack area has been examined metallographically and the fixing method for the the trunnion crack has been explained. Result of the study shows that the reason for the formation of the bearing trunnion crack can be the thermal stresses that occur during the mounting of the bearing trunnion to the turbine shaft and the material fatigue that occurs during the operation of the hydraulic turbine.
AtıfScopus9WoS7OpenAlex9İncele - MakaleAçık Erişim2021Scopus SJRQ3A novel macrofungus for the biosorption of hazardous dye and its reuse potential: Experimental design approach using response surface methodology
Ince, Olcay Kaplan; Alp, Hevidar; Ince, Muharrem; Onal, Ali
In the present study, a novel biosorbent, namely Agaricus campestris, was used for the removal of Methylene Blue (MB) from an aqueous medium. The biosorbent was characterized using fourier-transform infrared spectrometer spectra, scanning electron microscopy-energy dispersive X-ray, and thermogravimetric analysis. The influence of important process parameters including pH (4–7), temperature (25°C–35°C), contact time (15–25 min), and biosorbent amount (40–80 mg) on the uptake of MB solution were also optimized, which significantly affected the removal efficiency of MB. A central composite design (CCD) combined with response surface modeling (RSM) was carried out to maximize MB removal by A. campestris for the adsorption process. A regression model was derived using RSM to predict the responses and analysis of variance (ANOVA), and to check model adequacy lack of fit test was used. The A. campestris adsorption capacity was determined as 24.2 mg g–1. The ANOVA showed a high coefficient of determination (R2 = 0.9987). This study clearly revealed that RSM was one of the most effective and appropriate method for the optimization of operating conditions. The possibility of reusing A. campestris was also investigated and, as a result, it was found quite possible and showed high performance in the recovery of MB.
AtıfScopus2WoS1OpenAlex2İncele - MakaleAçık Erişim2021Scopus SJRQ1Influences of sample shape, voltage gradient, and electrode surface form on the exergoeconomic performance characteristics of ohmic thawing of frozen minced beef
Çokgezme, Ömer Faruk; Döner, Deniz; Çevik, Mutlu; Kemahlıoğlu, Ali Varsın; İçier, Filiz
In the present study, it was aimed to investigate the exergoeconomic performance of ohmic thawing (OT) system during the thawing of frozen minced meat (lean beef). The effects of the sample shape (X: 13 × 4 × 3 cm, Y: 13 × 6 × 2 cm, Z: cylinder with a height of 13 cm and diameter of 3.91 cm), electrode surface form (titanium foil with smooth surface, titanium electrode with needle-type surface and titanium electrode with pyramid-type surface), and voltage gradients (10, 13, and 16 V/cm) were investigated. Lower exergoeconomic values were obtained for the cylindrical shape compared to the rectangular prism. The lowest exergy efficiency value (12.45 ± 0.42), is was obtained for the cylindrical shape at 10 V/cm voltage gradient with titanium foil electrode. The needle-type surface electrodes had higher performance values than other electrodes. The exergoeconomic performance increased as the voltage gradient increased. The lowest unit exergy cost (72.40 ± 2.8) was obtained for rectangular prism shape at 16 V/cm with needle-type electrode. The comprehensive exergoeconomic evaluation in this study exhibited the energy utilization effectiveness and unit exergy cost of OT.
AtıfScopus32WoS28OpenAlex30İncele - MakaleAçık Erişim2021Scopus SJRQ3A MCDM Based on Goal Programming and GIS-Based Risk Assessment for the Evaluation of Educational Locations in Conflict Areas
Hallak, Jamil; Polat, Elifcan Göçmen
Conflict is recognized as a major barrier in socio-economic development. In conflict situations, most sectors such as health, food, shelter and education are adversely affected. The provision of education services to conflict-affected children saves them from becoming a lost generation and contributes to community building. Thus, we conducted this research to investigate the potential of a GIS (Geographic Information Systems) approach and risk assessment based multi-criteria decision making (MCDM) for the allocation of displaced dropped-out children to the most appropriate educational centres, taking into account multiple goals related to cost, distance, risk, etc. A two-stage approach was adopted, utilizing a risk assessment approach, and a location-allocation approach. The risk assessment approach was carried out using GIS and F-AHP (Fuzzy Analytic Hierarchy Process) to determine the risk value of each candidate educational centre in the conflict area. In the location-allocation stage, a mathematical model was developed to allocate all demands to the chosen centres. All presented methods were computationally conducted on real case data provided by direct beneficiaries and stakeholders in the 26 sub-districts in the Idleb governorate, Syria. The computational results demonstrate that the proposed approaches ensure practical and theoretical impacts.
AtıfScopus8WoS5OpenAlex7İncele - MakaleAçık Erişim2021Scopus SJRQ2Fabrication of porous-Ti6Al4V alloy by using hot pressing technique and Mg space holder for hard-tissue biomedical applications
Aslan, N.; Aksakal, B.; Findik, F.
Porous-Ti6Al4V (P-Ti6Al4V) alloys were produced using the hot pressing and spacer methods for hard tissue biomedical applications and in particular, the effects of porosity on the mechanical and morphological properties of the structures were investigated. P-Ti6Al4V structures having the homogeneously distributed porosities at 41.08, 52.37 and 64.10% were fabricated by adding 40, 50 and 60% spherical magnesium (Mg) powder with 350 μm particle sizes in average as spacers and evaporating magnesium via the atmosphere-controlled sintering. The obtained porous structures were characterized by SEM, XRD and EDS. Furthermore, the strength and elastic modulus were evaluated by performing compression tests. Elastic modulus and densities were found to be 40–171 MPa, 2–5 GPa and 1.59–2.61, respectively and these values have been shown to decrease with an increase in porosity. The achieved density and mechanical property values, in particular, elastic modulus are close to human bone and within acceptable ranges for with biomedical application purposes. In addition, it was also found out from the analysis of produced P-Ti6Al4V that macropores were responsible for mechanical anisotropy contributed to formation of homogeneous and inter-connected open pores. [Figure not available: see fulltext.]
AtıfScopus40WoS37OpenAlex39İncele - MakaleYalnız künye2021Scopus SJRQ3Investigation of the effect of baffle cut on heat transfer and pressure drop in shell-and-tube heat exchangers using CFD
Işık, Erdem; Tuğan, Volkan
The shell-and-tube heat exchanger (STHE) is one of the most widely used types of heat exchangers in industry. For this reason, studies conducted to improve the performance of STHEs are of great importance. In this study, a single-shell- and double-tube-pass STHE was designed, and a three-dimensional and steady-state flow analysis of this heat exchanger was conducted using the CFD method. The purpose of the analysis was to investigate the effect of baffle cut and mass flow rate of the fluid on the shell side on heat transfer and pressure drop by using the ANSYS Fluent, which is a type of computational fluid dynamics (CFD) software. For this aim, oil and water are used as working fluids in the shell and tubes of the STHE, respectively. Four different mass flow rates (0.6 kg/s, 0.8 kg/s, 1.0 kg/s, and 1.2 kg/s) are used for the fluid in the shell. In the analysis, three different STHEs with baffle cuts of 20%, 30%, and 40% are compared. According to the results of the CFD analysis, baffle cut plays an important role in heat transfer and pressure drop. The highest heat transfer per pressure drop was achieved for the STHE with 40% baffle cut and the lowest was achieved for the STHE with 20% baffle cut.
AtıfScopus13WoS8OpenAlex11İncele - MakaleAçık Erişim2021Scopus SJRQ4Presence of Neospora caninum DNA of Wild Birds from Turkey; [Türkiye’deki Vahşi Kuşlarda Neospora caninum DNA’sının Varlığı]
Karakavuk, Muhammet; Can, Hüseyin; Aldemir, Duygu; Döndüren, Ömer; Karakavuk, Tuğba; Karakavuk, Emrah; Özdemir, Hüseyin Gökhan; Muz, Mustafa Necati; Gürüz, Adnan Yüksel; Döşkaya, Mert
Objective: Neospora caninum is a protozoon parasite that has a worldwide distribution and mainly causes abortion in cattle and current serological evidence shows that the disease may be also zoonotic. Wild birds play a role as a reservoir of the disease in nature. The study aimed to determine the prensence of N. caninum in wild birds. Methods: In this study, the presence of neosporosis in wild birds (n=55) including 22 different species found in the western side of Turkey, was investigated by polymerase chain reaction (PCR). In addition, PCR positive samples were confirmed by sequencing, BLAST, and phylogenetic analysis using MEGA7. Results: Obtained results showed that the presence of N. caninum DNA was 5.45% (3/55) in brain-heart homogenates wild birds. The bird species which were found positive for N. caninum were little owl (Athene noctua), common buzzard (Buteo buteo), and little tern (Sternula albifrons). According to phylogenetic analysis and BLAST, all samples were compatible with reference N. caninum isolates. Conclusion: To the best of authors’ knowledge, this is the first study detecting N. caninum in little tern. In future studies, it may be interesting to investigate the prevalence of N. caninum in other wild animals to elucidate the transmission properties.
AtıfScopus3OpenAlex3İncele - Kitap BölümüYalnız künye2021Fine–kinney-based occupational risk assessment using fuzzy best and worst method (f-bwm) and fuzzy mairca
Gul, Muhammet; Mete, Suleyman; Serin, Faruk; Celik, Erkan
The best-worst method (BWM) proposed by Rezaei (Omega 53:49–57, [1]) is an MCDM method used to achieve the weights of the criteria by making fewer pairwise comparisons and using more consistent decision matrices. In this chapter, instead of crisp numbers, triangular fuzzy numbers that reflect the uncertainty well in real-world problems are used in integration with the BWM method (Guo and Zhao in Knowl Based Syst 121:23–31, [2]) in determining factor weights. Using the fuzzy best and worst method (F-BWM), a model based on Fine–Kinney occupational health and safety risk assessment method was developed for the first time in the literature. Three parameters of Fine–Kinney method are weighted by the mathematical models of F-BWM. Then, the risks are prioritized by fuzzy multi-attribute ideal real comparative analysis (F-MAIRCA). A case study was conducted to demonstrate the feasibility of the approach, and besides this case study, a comparative study was also conducted to test the validity of the proposed approach. This approach led to the conclusion that Fine–Kinney’s method, BWM, MAIRCA, and triangular fuzzy sets make the risk decision-making process more dynamic, taking into account the benefits of these methods individually or in integration.
AtıfScopus11OpenAlex12İncele - MakaleAçık Erişim2021Scopus SJRQ3Preliminary investigation on chemical composition and bioactivity of differently obtained extracts from Symphytum aintabicum Hub.- Mor. &Wickens
Zengin, Gokhan; Sinan, Kouadio Ibrahim; Ak, Gunes; Angeloni, Simone; Maggi, Filippo; Caprioli, Giovanni; Kaplan, Alevcan; Çakılcıoğlu, Uğur; Akan, Hasan; Jugreet, Sharmeen
Symphytum species, commonly known as comfrey, hold a long history of folk medicinal uses for healing wounds, bone fractures and other pain resulting from inflammation. However, many species belonging to this genus have not yet been scientifically investigated and hence investigation in this regard is warranted. In the present research, S. aintabicum extracts prepared by different extraction techniques (homogenizer assisted extraction, infusion and maceration) were assayed for their chemosystematic attributes (total phenolic, flavonoid) as well as bioactive compound contents, antioxidant and enzyme inhibition potentials. For instance, the extracts were found to possess phenolic and flavonoid levels ranging from 35.50 to 112.25 mg GAE/g and 2.54–25.12 mg RE/g, respectively. In general, the extracts displayed significant antioxidant activity. However, methanolic and infusion extracts were observed as the most potent radical scavengers and reducing agents, most likely related to their phenolic content. The extracts also showed metal chelating power and total antioxidant capacity in phosphomolybdenum assay. Moreover, while all extracts showed inhibition on amylase, only the methanolic extracts acted as inhibitors of cholinesterases and tyrosinase, most probably due to their relatively higher flavonoid content. The findings also indicated that the extraction method as well as the solvent type used to more or less affect the yield of the bioactive compounds and extracts’ bioactivity reported herein. Hence, as a first report highlighting the in vitro pharmacological properties of S. aintabicum, promising results were revealed from the quantitative chemosystematic analysis of bioactive components present and as sources of antioxidants and enzyme inhibitors against key human illnesses, thus providing scope for potential applications in phytomedicine development.
AtıfScopus15OpenAlex14İncele - MakaleYalnız künye2021Scopus SJRQ2Synthesis and in silico studies of Novel Ru(II) complexes of Schiff base derivatives of 3-[(4-amino-5-thioxo-1,2,4-triazole-3-yl)methyl]-2(3H)-benzoxazolone compounds as potent Glutathione S-transferase and Cholinesterases Inhibitor
Adiguzel, Ragip; Türkan, Fikret; Yildiko, Ümit; Aras, Abdülmelik; Evren, Enes; Onkol, Tijen
Novel Ru(II) complexes of Shiff base derivatives of 3-[(4-amino-5-thioxo-1,2,4-triazole-3-yl)methyl]-2(3H)-benzoxazolone were synthesized. The ligands (1a-e) were confirmed by IR, 1H NMR, and 13C NMR spectra (only 1b and 1c). Structures of the synthesized Ru(II) complexes (2a-e) were illuminated by elemental analysis, IR, 1H NMR, 13C NMR, and mass spectra. As the biological studies, the inhibitory potency of the ligands and the novel synthesized complexes were evaluated against the glutathione S-transferase (GST), acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes in vitro conditions. Ki values in the range of 26.87-47.63 µM for AChE, 23.51-42.81 µM for BChE, and 33.14-51.73 µM for GST, respectively. The free binding energy of most active inhibitors against AChE, BChE, and GST enzymes were detected as -10.183 kcal/mol, -9.111 kcal/mol, and -6.097 kcal/mol, respectively. All compounds docked were observed to bind in the active site of the enzymes with similar binding orientation and binding interactions with the surrounding amino acids.
AtıfScopus31OpenAlex34İncele - MakaleYalnız künye2021Scopus SJRQ2Characterization of Various Carbon-Based Polypropylene Nanocomposites
Kaya, Ozge; Buran, Dincer; Akkurt, Nevzat; Yapici, Kerim; Sarac, Mehmet Fahri
Pure and three types of carbon additives including graphite, graphene, and multi-walled carbon nanotube added into polypropylene (PP) composites as a vibration damping component and sound insulator material in the automotive sector were investigated by using vibrational damping, dynamic mechanical analysis (DMA), tensile, hardness and acoustic behavior tests. According to the obtained results, porosity and distribution of carbon in the polymer matrix are key parameters on the composite parameters causing its reduction of tensile strength and its brittle behavior. Moreover, it seems that 0.01 wt.% graphene and 1 wt.% graphite added PP composites show the highest impact damping properties and also increase the storage and loss modulus of the composite while decreasing the glass transition temperature. The loss factor obtained from DMA and vibration damping test indicated the damping capacity in the interphase of carbon added PP composites depends only on the load applied and not sensitivity upon the natural frequency of the composite system. Depending on the morphological differentiation, graphene added PP composites decrease the sound transmission loss while the 0.1 wt.% MWCNT added PP composites increase sound transmission loss which makes it an alternative vibration damping component.
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