Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Zengin, Gokhan(26)
- Erten, Fusun(20)
- Orhan, Cemal(17)
- Sahin, Kazim(17)
- Gul, Muhammet(15)
- Benzer, Fulya(12)
- Kocabaş, Mehmet(12)
- Aglar, Erdal(11)
- Serdar, Osman(11)
- Akkurt, Nevzat(10)
- Topal, Murat(10)
- Yeşiltepe, Akgün(10)
- Yucesan, Melih(10)
- Danabas, Durali(9)
- Er, Besir(9)
- Kutlu, Banu(9)
- Mahomoodally, Mohamad Fawzi(9)
- Uba, Abdullahi Ibrahim(9)
- Yildirim, Ozal(9)
- Öbek, Erdal(9)
- Acharya, U. Rajendra(8)
- Alp Dal, Nursel(8)
- Cakilcioglu, Ugur(8)
- Kandemir, Fatih Mehmet(8)
- Yildirim, Nuran Cikcikoglu(8)
- Arslan Topal, E. Işıl(7)
- Baloglu, Ulas Baran(7)
- Ozbey, Ulku(7)
- Sahin, Nurhan(7)
- Talo, Muhammed(7)
- Ates, Mehmet(6)
- Attar, Rukset(6)
- Dal, Nursel Alp(6)
- Gümüşsoy, Süreyya(6)
- Gürarslan Baş, Nazan(6)
- Ince, Muharrem(6)
- Kaplan Serin, Emine(6)
- Kutluyer, Filiz(6)
- Ozturk, Burhan(6)
- Aksu, Onder(5)
Yayınlar
- MakaleYalnız künye2023Scopus SJRQ1Evaluation of container port sustainability using WASPAS technique using on type-2 neutrosophic fuzzy numbers
Kaya, Sema Kayapinar; Kundu, Pradip; Görçün, Ömer Faruk
According to the common opinion in the literature, the sustainability of container ports is a tremendously complex topic owing to the maritime sector's excessively dynamic form and many highly complex, predictable and unpredictable uncertainties in this industry. The current paper proposes two powerful, practical, inspiring approaches to fill these gaps. It proposes a novel type-2 neutrosophic fuzzy numbers (T2NFNs) based Delphi method to determine the criteria logically and optimal and extends the WASPAS technique based on the T2NFNs for evaluating the alternatives. The current paper presents practical managerial implications that many stakeholders can consider, such as port authorities, ship owners, logistics service providers, governments, and local authorities, when making strategic and managerial decisions. In addition, the results of a comprehensive sensitivity analysis performed to test the robustness and applicability of the model approve the validity of the proposed T2NFN-based integrated approach.
AtıfScopus20WoS16OpenAlex24
İncele - MakaleYalnız künye2023Scopus SJRQ2Investigation of Antimicrobial, Anti-Quorum Sensing, and Cytotoxic Activities of Flavonoids Isolated from Pulicaria armena Boiss. & Kotschy ex Boiss. (Asteraceae)
Başpınar, Yasemin; Gürbüz, Perihan; Dilem Doğan, Şengül; Gözde Gündüz, Miyase; Aleksic, Ivana; Vojnovic, Sandra; Nikodinovic-Runic, Jasmina; Yavuz Paksoy, Mehmet
This is the first report on the separation and biological assessment of all metabolites derived from Pulicaria armena (Asteraceae) which is an endemic species narrowly distributed in the eastern part of Turkey. The phytochemical analysis of P. armena resulted in the identification of one simple phenolic glucoside together with eight flavon and flavonol derivatives whose chemical structures were elucidated by NMR experiments and by the comparison of the spectral data with the relevant literature. The screening of all molecules for their antimicrobial, anti-quorum sensing, and cytotoxic activities revealed the biological potential of some of the isolated compounds. Additionally, quorum sensing inhibitory activity of quercetagetin 5,7,3’ trimethyl ether was supported by molecular docking studies in the active site of LasR which is the primary regulator of this cell-to-cell communication system in bacteria. Lastly, the critical molecular properties indicating drug-likeness of the compounds isolated from P. armena were predicted. As microbial infections can be a serious problem for cancer patients with compromised immune systems, this comprehensive phytochemical research on P. armena with its anti-quorum sensing and cytotoxic compounds can provide a new approach to the treatment.
AtıfScopus1OpenAlex1İncele - MakaleAçık Erişim2023Scopus SJRQ1Integrating stratified best–worst method and GIS for landslide susceptibility assessment: a case study in Erzurum province (Turkey)
Konurhan, Zekeriya; Yucesan, Melih; Gul, Muhammet
Landslides are among the most destructive geological disasters that seriously damage human life and infrastructures. Landslides mainly occur in mountainous regions around the world. One of the key processes to reduce these damages is to uncover landslide-exposed areas through different data-driven methods such as Geographical Information System (GIS) and multi-criteria decision-making (MCDM). In the literature, there are many studies developed with these fundamental tools. In this study, unlike the literature, a new landslide susceptibility assessment model is proposed by integrating GIS with the stratified best–worst method (S-BWM). This model has four main dimensions and 16 sub-dimensions under topography, environment-land, location, and hydrological factors, weighted with the S-BWM. A network was created considering the different states that may arise in the importance weights of these dimensions in the future. The transition probabilities of these states were predicted and injected into the classical BWM. Then, maps were created for these dimensions and classifications for each sub-dimension according to the map characteristics. Finally, the most susceptive landslide locations were determined with GIS-based calculations. To demonstrate the model’s applicability, a case study was conducted for the Erzurum region, one of Turkey’s landslide-prone regions. In addition, besides the landslide map, an analysis and discussion about the spatial distribution of susceptibility classes was presented, contributing to the study’s robustness. In the results of landslide susceptibility analysis, landslides are higher in the range of about 1600–2500 m. Approximately 42% (35.59 sq. km) of the study area has high landslide susceptibility, while 58% (64.41 sq. km) has medium and low landslide susceptibility.
AtıfScopus19WoS17OpenAlex18İncele - MakaleYalnız künye2023Scopus SJRQ2Antibacterial activity of novel synthesized chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites for biomedical application
Yazdıç, Ferit Can; Karaman, Altuğ; Torğut, Gülben; Ayhan, Nagihan Karaaslan
In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N‑tert‑BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique. Nd was successfully incorporated into the polymer of different weight percentages (0.5%, 1%, and 2%) without any degradation. The effect of neodymium additives on the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer was analyzed using various instrument techniques. X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N‑tert‑BAAm) composites without any other impurities. The antibacterial effect of Nd was studied by adding it to the copolymer in a weight ratio of 0.5%–2%. The antibacterial effect of neodymium concentration on four different strains of bacteria was investigated: Escherichia coli (ATCC 25922) (E. coli), Pseudomonas aeruginosa (DSM 50071) (P. aeruginosa), Bacillus subtilis (DSM 1971) (B. subtilis), and Staphylococcus aureus subsp. aureus (ATCC 25923) (S. aureus). The antibacterial activities of the obtained composites were determined using the Agar Well Diffusion Assay Method. Experimental results show that Nd binds well to CH-graft-poly(N‑tert‑BAAm). Activity against E. coli, P. aeruginosa, B. subtilis, and S. aureus subsp. aureus creates a potential for pharmaceutical and biomedical applications.
AtıfScopus8WoS7OpenAlex8İncele - MakaleAçık Erişim2023Scopus SJRQ1Bioaccumulation Pattern and Health Risk Assessment of Heavy Metals in Cirrhinus mrigala at Panjnad Headworks, Bahawalpur, Pakistan
Naz, Saima; Chatha, Ahmad Manan Mustafa; Danabas, Durali; Khan, Muhammad Farhan; Xu, Youhou; Zhu, Peng; Shafique, Laiba
Heavy metal accumulation in freshwater ecosystem has become one of the major aquatic environmental concerns for freshwater flora and fauna due to their higher stability and bioaccumulation as well as bio-magnification properties. Furthermore, passing through the food web, these heavy metals affect human populations ultimately. This study assessed the heavy metal accumulation in Cirrhinus mrigala in spring, autumn, and winter at different locations (I, II, and III) of Panjnad headwork. Furthermore, the human health risk assessment for the consumption of C. mrigala from the sampling locations was also carried out. Fish were collected from upper (I), middle (II), and lower (III) stream of Panjnad on a monthly basis. The current study evaluated the accumulation of Aluminum (Al), Arsenic (As), Barium (Ba), and Lead (Pb) in various fish organs (liver, kidney, gills, fins, skin, muscles and bones) and assessed their potential hazard to human health through health risk assessment indicators. The results demonstrated a significant difference (p < 0.05) in heavy metal accumulation in different fish organs, seasons, and locations. The accumulation of Al, As, Ba, and Pb were considerably higher in liver and kidney as compared to the other body organs and followed a trend of liver > kidney > gills > fins > skin > bones > muscle and the overall mean concentrations of metals in different body tissues of C. mrigala were in the order of Al > As > Ba > Pb. The results also concluded that C. mrigala caught from the Panjnad headwork is not safe for human consumption due to higher values of TTHQIng (3.76), THQIng for Ba (3.27) and CRIng for As (6.4742).
AtıfScopus27OpenAlex25İncele - MakaleAçık Erişim2023Scopus SJRQ2ResMIBCU-Net: an encoder–decoder network with residual blocks, modified inverted residual block, and bi-directional ConvLSTM for impacted tooth segmentation in panoramic X-ray images
Imak, Andaç; Çelebi, Adalet; Polat, Onur; Türkoğlu, Muammer; Şengür, Abdulkadir
Objective: Impacted tooth is a common problem that can occur at any age, causing tooth decay, root resorption, and pain in the later stages. In recent years, major advances have been made in medical imaging segmentation using deep convolutional neural network-based networks. In this study, we report on the development of an artificial intelligence system for the automatic identification of impacted tooth from panoramic dental X-ray images. Methods: Among existing networks, in medical imaging segmentation, U-Net architectures are widely implemented. In this article, for dental X-ray image segmentation, blocks and convolutional block structures using inverted residual blocks are upgraded by taking advantage of U-Net’s network capacity-intensive connections. At the same time, we propose a method for jumping connections in which bi-directional convolution long short-term memory is used instead of a simple connection. Assessment of the proposed artificial intelligence model performance was evaluated with accuracy, F1-score, intersection over union, and recall. Results: In the proposed method, experimental results are obtained with 99.82% accuracy, 91.59% F1-score, 84.48% intersection over union, and 90.71% recall. Conclusion: Our findings show that our artificial intelligence system could help with future diagnostic support in clinical practice.
AtıfScopus21OpenAlex23İncele - MakaleAçık Erişim2023Scopus SJRQ1Adding New Scientific Evidences on the Pharmaceutical Properties of Pelargonium quercetorum Agnew Extracts by Using In Vitro and In Silico Approaches
Chiavaroli, Annalisa; Libero, Maria Loreta; Di Simone, Simonetta Cristina; Acquaviva, Alessandra; Nilofar; Recinella, Lucia; Leone, Sheila; Brunetti, Luigi; Cicia, Donatella; Izzo, Angelo Antonio
Pelargonium quercetorum is a medicinal plant traditionally used for treating intestinal worms. In the present study, the chemical composition and bio-pharmacological properties of P. quercetorum extracts were investigated. Enzyme inhibition and scavenging/reducing properties of water, methanol, and ethyl acetate extracts were assayed. The extracts were also studied in an ex vivo experimental model of colon inflammation, and in this context the gene expression of cyclooxygenase-2 (COX-2) and tumor necrosis factor α (TNFα) were assayed. Additionally, in colon cancer HCT116 cells, the gene expression of transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), possibly involved in colon carcinogenesis, was conducted as well. The extracts showed a different qualitative and quantitative content of phytochemicals, with water and methanol extracts being richer in total phenols and flavonoids, among which are flavonol glycosides and hydroxycinnamic acids. This could explain, at least in part, the higher antioxidant effects shown by methanol and water extracts, compared with ethyl acetate extract. By contrast, the ethyl acetate was more effective as cytotoxic agent against colon cancer cells, and this could be related, albeit partially, to the content of thymol and to its putative ability to downregulate TRPM8 gene expression. Additionally, the ethyl acetate extract was effective in inhibiting the gene expression of COX-2 and TNFα in isolated colon tissue exposed to LPS. Overall, the present results support future studies for investigating protective effects against gut inflammatory diseases.
AtıfScopus35OpenAlex35İncele - MakaleYalnız künye2023Scopus SJRQ1Effect of type and concentration of cryoprotectant on the motility, viability, and fertility of climbing perch Anabas testudineus Bloch, 1792 (Pisces: Anabantidae) sperm
Maulida, Siti; Eriani, Kartini; Fadli, Nur; Kocabaş, Filiz Kutluyer; Siti-Azizah, Mohd Nor; Wilkes, Martin; Muchlisin, Zainal Abidin
The climbing perch, Anabas testudineus is a freshwater fish that has economic value in Indonesia. It is cultured in the country, but the breeding technology, specifically sperm storage, is not well developed. Sperm cryopreservation is one of the preservation methods that need to be developed to support fish breeding technology. The type of cryoprotectants and its concentration are species-dependent and determines the success of this approach. Therefore, this study is aimed at determining the optimal type and concentration of cryoprotectant for sperm cryopreservation of A. testudineus. Four separate study series were performed, each of which evaluated one type of cryoprotectant at five concentration levels. The cryoprotectants used were DMSO, methanol, glycerol, and ethanol, and the tested concentrations were 0%, 5%, 10%, 15%, and 20%, which were combined with 5% egg yolks. Each treatment was conducted with three replications. The results showed that the type of cryoprotectant and its concentration significantly affected sperm motility, viability, and fertility of climbing perch (P < 0.05). The best outcome was obtained in DMSO, and methanol at a concentration of 10%, glycerol at 5%, and ethanol at 15%. However, the highest motility, viability, and fertility values were observed at 10% DMSO, indicating it is the best type and concentration for sperm cryopreservation of climbing perch A. testudineus.
AtıfScopus10WoS7OpenAlex11İncele - MakaleAçık Erişim2023Scopus SJRQ1Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from Nepeta italica
Acquaviva, Alessandra; Di Simone, Simonetta Cristina; Nilofar; Bouyahya, Abdelhakim; Zengin, Gokhan; Recinella, Lucia; Leone, Sheila; Brunetti, Luigi; Uba, Abdullahi Ibrahim; Guler, Osman
Plants from the Nepeta genus have been proved to possess different pharmacological properties, among which are antimicrobial, antioxidant, anti-inflammatory, analgesic, and cytotoxic effects. Nepeta italica is a medicinal plant traditionally used for its analgesic effects, and in the present study, the phytochemical composition and biological effects of hexane, dichloromethane (DCM), ethyl acetate (EA), ethanol, ethanol-water, and water extracts of the aerial parts were investigated for determining phenolic composition, antioxidant effects, and anti-inflammatory effects in isolated mouse colon specimens exposed to lipopolysaccharide (LPS). Polar extracts were the richest in terms of phenolic compounds, especially rosmarinic acid. In parallel, ethanol, ethanol-water, and water extracts were also the most effective as scavenging/reducing and enzyme inhibition agents, especially towards cholinesterases and α-glucosidase, and in inhibiting the LPS-induced cyclooxygenase-2 (COX-2) and tumor necrosis factor α (TNFα) gene expression in mouse colon. This poses the basis for future in vivo investigations for confirming the protective effects of polar extracts of N. italica against inflammatory bowel diseases.
AtıfScopus31OpenAlex31İncele - MakaleAçık Erişim2023Scopus SJRQ1Lutein/Zeaxanthin Isomers and Quercetagetin Combination Safeguards the Retina from Photo-Oxidative Damage by Modulating Neuroplasticity Markers and the Nrf2 Pathway
Sahin, Emre; Orhan, Cemal; Sahin, Nurhan; Padigaru, Muralidhara; Morde, Abhijeet; Lal, Mohan; Dhavan, Nanasaheb; Erten, Fusun; Bilgic, Ahmet Alp; Ozercan, Ibrahim Hanifi
Exposure to light-emitting diode (LED) light is a primary cause of retinal damage, resulting in vision loss. Several plant-derived substances, such as lutein and quercetagetin (QCG), show promise in supporting eye health. In this study, the impact of lutein/zeaxanthin (L/Z, Lutemax 2020) and QCG were evaluated individually and together in a rat model of LED-induced retinal damage. A total of 63 Wistar rats were allocated into nine groups (n = 7). For 28 days, the rats received L/Z (10 or 20 mg/kg BW), quercetin (QC, 20 mg/kg BW), QCG (10 or 20 mg/kg BW), or a mixture of different lutein and QCG dosages, after which they were exposed to LED light for 48 h. LED exposure led to a spike in serum malondialdehyde (MDA) and inflammatory cytokines, as well as an increase in retinal NF-κB, ICAM, GFAP, and MCP-1 levels (p < 0.0001 for all). It also reduced serum antioxidant enzyme activities and retinal Nrf2, HO-1, GAP43, NCAM, and outer nuclear layer (ONL) thickness (p < 0.0001 for all). However, administering L/Z and QCG, particularly a 1:1 combination of L/Z and QCG at 20 mg/kg, effectively reversed these changes. The treatment suppressed NF-κB, ICAM, GFAP, and MCP-1 while enhancing Nrf2, HO-1, GAP43, and NCAM and preventing ONL thickness reduction in LED-induced retinal damage rats. In conclusion, while LED light exposure caused retinal damage, treatment with L/Z, QC, and QCG, particularly a combined L/Z and QCG regimen, exhibited protective effects on the retina. This is possibly due to the modulation of neuroplasticity markers and nuclear transcription factors in the rats’ retinal cells.
AtıfScopus22OpenAlex22İncele - MakaleAçık Erişim2023Scopus SJRQ1Evaluation of metal pollution related to human health risk in freshwater snail Viviparus contectus (Millet, 1813) as a potential bioindicator species in Lake Habitat (Turkey)
Kutluyer Kocabaş, Filiz; Göktürk Aksu, Emsiye; Kocabaş, Mehmet
Freshwater mollusks are employed as bioindicators for the assessment of water quality in biomonitoring studies since the water quality of natural resources is crucial for humans. The freshwater snail species known as Viviparus contectus (Viviparidae: Gastropoda) is one that people eat. Here, the levels of heavy metals (Cd, Cr, Pb, As, Zn, and Cu) in water and V. contectus samples were determined. An Inductively Coupled Plasma Atomic Emission Spectrometer (ICP-AES, Spectro Arcos, vertical plasma) was used for the analysing the heavy metal concentrations in water and freshwater snail samples. The results of the current investigation demonstrated that freshwater snails accumulated metals in their water and soft tissues in the following orders: Pb > Cr = Zn = Cu = Cd = As and Zn > Cu > Pb > Cd > As = Cr. Autumn was the time of year when higher amounts of heavy metals (As, Cr, Cu, Zn, and Hg) were found. Pb content in the freshwater snail samples was strongly impacted by seasonal fluctuations (P 0.05). For adults, the EDI (estimated daily intake) values were lower than the TDI (tolerable daily intake) values, and the HI (hazard index) values were below 1. Freshwater snail samples had Zn and Pb levels that were over the FAO/WHO, Turkish Food Codex, JECFA, and EC limit values. Except for Pb, the water study shows mean metal concentrations below the USEPA, Turkish Pollution Control Regulation, and World Health Organisation maximum allowed levels. Aquatic ecosystems were negatively impacted by anthropogenic activities overall, and this study can provide a helpful data set for investigations on metallic contamination in water bodies and biomonitoring in freshwater ecosystems.
AtıfScopus7WoS6OpenAlex6İncele - MakaleAçık Erişim2023Scopus SJRQ1Deep learning based hybrid prediction model for predicting the spread of COVID-19 in the world's most populous countries
Utku, Anil
COVID-19 has a disease and health phenomenon and has sociological and economic adverse effects. Accurate prediction of the spread of the epidemic will help in the planning of health management and the development of economic and sociological action plans. In the literature, there are many studies to analyse and predict the spread of COVID-19 in cities and countries. However, there is no study to predict and analyse the cross-country spread in the world's most populous countries. In this study, it was aimed to predict the spread of the COVID-19 epidemic. The motivation of this study is to reduce the workload of health workers, take preventive measures and optimize health processes by predicting the spread of the COVID-19 epidemic. A hybrid deep learning model was developed to predict and analyse COVID-19 cross-country spread and a case study was carried out for the world's most populous countries. The developed model was tested extensively using RMSE, MAE and R2. The experimental results showed that the developed model was more successful in predicting and analysis of COVID-19 cross-country spread in the world's most populous countries than LR, RF, SVM, MLP, CNN, GRU, LSTM and base CNN-GRU. In the developed model, CNN performs convolution and pooling operations to extract spatial features from the input data. GRU provides learning of long-term and non-linear relationships inferred by CNN. The developed hybrid model was more successful than the other models compared, as it enabled the effective features of the CNN and GRU models to be used together. The prediction and analysis of the cross-country spread of COVID-19 in the world's most populated countries can be presented as a novelty of this study.
AtıfScopus23WoS20OpenAlex31İncele - MakaleAçık Erişim2023Scopus SJRQ2Shape Memory Polymer-Based Nanocomposites Magnetically Enhanced with Fe3O4 Nanoparticles
Pekdemir, Mustafa Ersin; Aydin, Derya; Selçuk Pekdemir, Sibel; Erecevit Sönmez, Pınar; Aksoy, Edanur
This work aimed to investigate the effect of magnetic Fe3O4 nanoparticles (MNP), which are known to have a wide range of applications in recent years, on nanocomposite films prepared with shape memory polymers. Herein, PLA–PEG blend nanocomposite films were prepared by solution casting method using MNP at different ratios. PLA–PEG Blend/MNP nanocomposite films were characterized with Attenuated total reflection infrared spectroscopy (ATR-IR) to determine the –C=O stretching of PLA and Fe–O stretching signals of Fe3O4. The thermal stability, morphology, and magnetic behavior were studied by comparing the results among PLA–PEG blend, PLA–PEG blend/MNP nanocomposite with thermogravimetric analyses (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and a vibrating sample magnetometer (VSM), respectively. The effect of MNP on the shape memory properties of PLA/PEG blend was investigated. Moreover, the comparison of antimicrobial activity between PLA/PEG blend and PLA–PEG blend/MNP nanocomposite films were conducted by the disk diffusion method. The results showed that MNP increased the thermal stability of the PLA/PEG blend and the nanocomposites inhibited the growth of C.albicans microorganism. Graphical Abstract: [Figure not available: see fulltext.].
AtıfScopus41WoS39OpenAlex42İncele - MakaleYalnız künye2023Scopus SJRQ2Microplastic pollution in two remote rivers of Türkiye
Gündoğdu, Sedat; Kutlu, Banu; Özcan, Tahir; Büyükdeveci, Ferhat; Blettler, Martin C. M.
Microplastic pollution in aquatic ecosystems presents an emerging environmental threat that can have adverse effects on ecology, endanger aquatic species, and result in economic damage. Despite the numerous studies reporting the presence of microplastics in marine environments, research into their presence in freshwater systems or inland waters remains limited. This study aimed to assess the level of microplastic pollution transported by the Munzur and Pülümür Rivers and some small rivers that flow into the Uzunçayır dam lake, which is the confluence of the Munzur and Pülümür Rivers in Türkiye. Samples were collected from 23 stations, with the concentration of microplastics ranging from 0.01 MP/m3 at P-4 station to 28.21 MP/m3 at P-10, a station located near a city. Microplastics comprise four types: fiber, film, fragment, and glitter. The average size of microplastics was 1.46 ± 0.05 mm, with the average size of fibers, films, fragments, and glitter-type microplastics being 1.58 ± 0.07 mm, 1.23 ± 0.10 mm, 1.21 ± 0.11 mm, and 0.78 ± 0.16 mm, respectively. The most frequent polymers were polyethylene (31.8%), polystyrene (21.1%), and polypropylene (10.5%). Despite being considered remote and less populated rivers compared to other river systems in Türkiye, all sampling sites showed varying concentrations of microplastics.
AtıfScopus34OpenAlex37İncele - MakaleYalnız künye2023Scopus SJRQ1Cytoprotective, antimutagenic/antirecombinogenic and antibacterial properties of Lallemantia iberica extracts
Yilmaz Kardas, Begumhan; Diken, Mehmet Emin; Bayhan, Hamza; Acar, Mikail; Dogan, Serap
BACKGROUND: Plants have important chemical compounds to protect organisms from many mutagens but they may also have dangerous toxic substances that must be tested before use. Lallemantia iberica has been used by local people for treatment of some diseases but it was never tested for its cell protective and antimutagenic/antirecombinogenic properties. In this study, it was aimed to determine the cytoprotective, antimutagenic/antirecombinogenic, antibacterial, antioxidant and phenolic profile of L. iberica by MTS assay, micronucleus test/somatic mutation recombination test (SMART), disc diffusion method, ABTS/DPPH tests and liquid chromatography (LC), respectively. RESULTS: MTS assay results showed that both of the extracts supported the normal growth of healthy human lymphocytes and there was no significant difference between extracts. Although there was no significant increase in micronucleus concentration (‰) of the cultures treated with ethanol or methanol extracts, methanol extract caused slightly lower micronucleus concentration (12.64 ± 3.65‰) than the ethanol extract (24.46 ± 4.50‰). SMART results showed that ethanol and methanol extracts prevented harmful mitotic recombination. Lallemantia iberica also showed antibacterial activity against all of the strains tested, and the largest inhibition zones were observed with Pseudomonas aeruginosa (17.9 mm) and Enterobacter aerogenes (13.8 mm). Methanol extracts showed better antioxidant activities (ABTS IC50: 104.07 μg mL−1, DPPH IC50: 58.8 μg mL−1) than ethanol extracts (ABTS IC50: 344.03 μg mL−1, DPPH IC50: 233.7 μg mL−1). According to the LC results, the most abundant phenolic compounds were rutin hydrate (1796.4 ± 62.9 mg kg−1) and p-coumaric acid (228.1 ± 7.60 mg kg−1). CONCLUSION: Lallemantia iberica extracts had cell-protective, antimutagenic/antirecombinogenic, antibacterial and strong antioxidant characteristics in relation to their rich phenolic content.
AtıfScopus7WoS5OpenAlex9İncele - MakaleYalnız künye2023Scopus SJRQ1The relationship between unemployment anxiety, job satisfaction and migration attitude among the next generation of Turkish nurses: A cross-sectional study
Öncü, Emine; Köksoy Vayısoğlu, Sümbüle; Karadağ, Gülendam; Şahin Orak, Nuray; Selçuk Tosun, Alime; Yüksekol, Özlem Doğan; Çatıker, Aslıhan; Yalçın, Gülcan Çiftçioğlu
Background: The global nursing shortage is complex and multifaceted. Despite the policy of increasing the number of nurses, concerns about the sustainability of the nursing workforce in Turkey continue. Aim: To evaluate the relationship between unemployment anxiety, job satisfaction, and migration attitudes among Turkish nursing candidates. Methods: A cross-sectional study was conducted with 1100 nursing candidates between April and June 2022. The data gathered from the “Personal Form, Job Satisfaction, and Brain Drain Attitudes Scale” were analyzed using logistic regression and decision tree analysis. Results: Of the participants, 67.1% were female, and the mean age was 22.6 ± 1.7 years. Being male (OR = 1.317, 95% Cl 0.994–1.743) having a low income (OR = 1.754, 95% Cl 1.334–2.306), feeling insecure about the future (OR = 2.340, 95% Cl 1.312–4.175), expecting a lower wage than desired (OR = 2.015, 95% Cl 1.132–3.586), and employment precariousness (OR = 1.786, 95% Cl 1.355–2.353) increase the possibility of experiencing high unemployment anxiety. On the other hand, family support for living abroad (OR = 0.579, 95% CI 0.408–0.821) and job satisfaction (OR = 0.799, 95% CI 0.692–0.921) decrease unemployment anxiety (p < 0.05). According to the results of the decision tree analysis, the host country's pull factors are the best predictors of the nursing candidates' intention to work abroad as nurses (p < 0.05). Conclusion: The increasing prevalence of unemployment anxiety and migration tendencies among nursing candidates requires the evaluation of policies aimed at increasing the number of nursing graduates in Turkey.
AtıfScopus9OpenAlex16İncele - MakaleYalnız künye2023Scopus SJRQ2Genotoxic effect of iron oxide (Fe2O3) nanoparticles on Triticum aestivum (wheat)
Tasar, Neslihan
Industrial activities and unconscious consumption of natural resources cause environmental pollution with the rapid increase in the world population. As a result of the widespread use of iron oxide nanoparticles (Fe2O3 NP) with nano-industrial activities, it is predicted that this NP will accumulate in the air, water, and soil. In the present study, the purpose was to find out the genotoxic effects on root meristem cells of the Triticum aestivum L. plant, which is an indicator organism exposed to 20–40 nm Fe2O3 NPs at different concentrations (100, 200, and 400 ppm). The amount of Fe2O3 NP accumulated in T. aestivum used in the study was determined with x-ray diffraction (XRD) spectroscopy, scanning electron microscopy (SEM), SEM element map, and EDS characteristic spectrum. All concentrations of Fe2O3 NP caused significant decreases in the mitotic index. Fe2O3 NPs significantly increased the frequency of mitotic abnormalities in T. aestivum root tip cells at all treatment times and all concentrations when compared to the control. Fe2O3 NPs were formed by various mitotic abnormalities such as loss of genetic material, deconstructed prophase, adhesion, chromosome groupings in metaphase, deconstructed metaphase, C-Metaphase, chromosomal loss, chromosomal fracture, polyploidy, deconstructed anaphase, lagging chromosome, fragment, polar deviation, bridging, propagation, asynchronous division, star anaphase, multipolarity, and deconstructed telophase. All these results show that Fe2O3 NPs are genotoxic and clastogenic and may also cause DNA damage. Briefly, these data show that Fe2O3 NPs taken by organisms may pose a danger to the organism and the upper consumer. These findings also show that the production and use of Fe2O3 NPs, which affect organisms, must be controlled, and ultimately, be safely disposed of to reduce their bioaccumulation. Research Highlights: In the present study, the purpose was to find out the genotoxic effects on root meristem cells of the Triticum aestivum L. (bread wheat) plant, which is an indicator organism exposed to 20–40 nm Fe2O3 NPs at different concentrations (100, 200, and 400 ppm). The amount of Fe2O3 NP accumulated in T. aestivum used in the study was determined with x-ray diffraction (XRD) spectroscopy, scanning electron microscopy (SEM), SEM element map, and EDS characteristic spectrum. The mitotic index was calculated to reveal the genotoxic effect. “Loss of genetic material, deconstructed prophase, adhesion, chromosome groupings in metaphase, deconstructed metaphase, C-Metaphase, chromosomal loss, chromosomal fracture, polyploidy, deconstructed anaphase, lagging chromosome, fragment, polar deviation, bridging, propagation, asynchronous division, star Chromosomal abnormalities such as anaphase, multipolarity, and deconstructed telophase” were visualized. Fe2O3 NPs are genotoxic and clastogenic and may also cause DNA damage.
AtıfScopus10WoS7OpenAlex11İncele - MakaleAçık Erişim2023Scopus SJRQ2Fabrication of hydroxyapatite-based nano-gold and nano-silver-doped bioceramic bone grafts: Enhanced mechanostructure, cell viability, and nuclear abnormality properties
Demirel, M.; Aslan, N.; Aksakal, B.; Arslan, M.E.
In this study, nano-gold (nAu) and nano-silver (nAg) were doped at the molar ratios of Molar5–Molar30 to the Hydroxyapatite (HAp)-based bioceramic bone graft synthesized by the sol–gel method. The effects of nAu and nAg on structural, mechanical, cell viability, and nuclear abnormality of the synthesized bioceramic grafts were evaluated. The chemical and morphological properties of the bone grafts after production were examined through XRD and SEM–EDX analyses and mechanical tests. To determine the biocompatibility of the bone grafts, cell viability tests were performed using human fibroblast cells. In the cytotoxicity analyses, only HAp and HAp-nAu5 grafts did not show toxicological properties at any concentration, while HAp-nAg5 among the nAg-containing grafts gave the best results at the 200–100 μg/mL concentrations and showed significant cytotoxicity in human fibroblast cells. The other nAu-containing grafts showed toxicological properties in the concentration range of 200–50 μg/mL and nAg-containing grafts in the concentration range of 200–100 μg/mL against the negative control. The micronucleus (MN) analyses showed that the lowest total MN and L (lobbed) amounts, while the lowest total N (notched) amount, was obtained from the only HAp graft. It was found that the nAg-doped bone grafts gave higher total MN, L, and N amounts compared to the nAu-doped bone grafts. Furthermore, while the mean nuclear abnormality (NA) values of all grafts gave close results, the highest values were again obtained from the nAg-doped bone grafts.
AtıfScopus7WoS6OpenAlex9İncele - MakaleAçık Erişim2023Scopus SJRQ1Orbitrap Mass Spectrometry-Based Profiling of Secondary Metabolites in Two Unexplored Eminium Species and Bioactivity Potential
Babacan, Ebru Yuce; Zheleva-Dimitrova, Dimitrina; Gevrenova, Reneta; Bouyahya, Abdelhakim; Balos, Mehmet Maruf; Cakilcioglu, Ugur; Sinan, Kouadio Ibrahime; Zengin, Gokhan
The study aimed at the metabolite profiling and evaluation of antioxidant and enzyme inhibitory properties of methanol extracts from flowers, leaves, and tubers of unexplored Eminium intortum (Banks & Sol.) Kuntze and E. spiculatum (Blume) Schott (Araceae). A total of 83 metabolites, including 19 phenolic acids, 46 flavonoids, 11 amino, and 7 fatty acids were identified by UHPLC-HRMS in the studied extracts for the first time. E. intortum flower and leaf extracts had the highest total phenolic and flavonoid contents (50.82 ± 0.71 mg GAE/g and 65.08 ± 0.38 RE/g, respectively). Significant radical scavenging activity (32.20 ± 1.26 and 54.34 ± 0.53 mg TE/g for DPPH and ABTS) and reducing power (88.27 ± 1.49 and 33.13 ± 0.68 mg TE/g for CUPRAC and FRAP) were observed in leaf extracts. E. intortum flowers showed the maximum anticholinesterase activity (2.72 ± 0.03 mg GALAE/g). E. spiculatum leaves and tubers exhibited the highest inhibition towards α-glucosidase (0.99 ± 0.02 ACAE/g) and tirosinase (50.73 ± 2.29 mg KAE/g), respectively. A multivariate analysis revealed that O-hydroxycinnamoylglycosyl-C-flavonoid glycosides mostly accounted for the discrimination of both species. Thus, E. intortum and E. spiculatum can be considered as potential candidates for designing functional ingredients in the pharmaceutical and nutraceutical industries.
AtıfScopus15OpenAlex11İncele - MakaleYalnız künye2023Scopus SJRQ2Does surgery cause anxiety, stress and fear in geriatric patients?
Karabulut, Neziha; Gürçayır, Dilek; Abi, Özlem; Kızıloğlu Ağgül, Beyzanur; Söylemez, Nilgün
Background: Because of physiological changes in geriatric patients, their surgical process differs from that of young adults. In this regard, the perioperative period is an extremely risky time for geriatric patients. The present study examined preoperative fear, anxiety, and perceived stress levels as well as the factors affecting them in elderly patients prior to surgical intervention. Methods: This study adopted a cross-sectional descriptive design. The study sample consisted of geriatric patients (n = 407) scheduled for elective laparoscopic cholecystectomy in a research and training hospital in northeast Turkey. Data were collected by the researchers using the personal information form, Perceived Stress Scale (PSS-10), Surgical Fear Questionnaire (SFQ) and Anxiety Specific to Surgery Questionnaire (ASSQ). In the data analysis, descriptive statistics, the t-test in independent groups, one-way analysis of variance (ANOVA), correlation analysis and Bonferroni tests for post hoc analyses were used. Results: On the PSS–10, the mean score was higher for the 75-and-older age group, single patients, patients with a disease requiring medication, and those who had previously undergone surgery (P < 0.05). On the ASSQ, the mean score was lower for patients aged 65–69, university graduates, patients without children, and those without a disease requiring medication (P < 0.05). On the SFQ, the mean score was higher for the 75-and-older age group, primary school graduates, and single patients (P < 0.05). Conclusion: It was determined that being single, having a chronic disability, and advancing age had an effect on the patients' surgery-specific anxiety, perceived stress, and fear of surgery. Long-standing chronic diseases can negatively affect both stress and anxiety levels of individuals.
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