Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Zengin, Gokhan(26)
- Erten, Fusun(20)
- Orhan, Cemal(17)
- Sahin, Kazim(17)
- Gul, Muhammet(15)
- Benzer, Fulya(12)
- Kocabaş, Mehmet(12)
- Aglar, Erdal(11)
- Serdar, Osman(11)
- Akkurt, Nevzat(10)
- Topal, Murat(10)
- Yeşiltepe, Akgün(10)
- Yucesan, Melih(10)
- Danabas, Durali(9)
- Er, Besir(9)
- Kutlu, Banu(9)
- Mahomoodally, Mohamad Fawzi(9)
- Uba, Abdullahi Ibrahim(9)
- Yildirim, Ozal(9)
- Öbek, Erdal(9)
- Acharya, U. Rajendra(8)
- Alp Dal, Nursel(8)
- Cakilcioglu, Ugur(8)
- Kandemir, Fatih Mehmet(8)
- Yildirim, Nuran Cikcikoglu(8)
- Arslan Topal, E. Işıl(7)
- Baloglu, Ulas Baran(7)
- Ozbey, Ulku(7)
- Sahin, Nurhan(7)
- Talo, Muhammed(7)
- Ates, Mehmet(6)
- Attar, Rukset(6)
- Dal, Nursel Alp(6)
- Gümüşsoy, Süreyya(6)
- Gürarslan Baş, Nazan(6)
- Ince, Muharrem(6)
- Kaplan Serin, Emine(6)
- Kutluyer, Filiz(6)
- Ozturk, Burhan(6)
- Aksu, Onder(5)
Yayınlar
- MakaleAçık Erişim2025Scopus SJRQ3The Level of Intimate Partner Violence Against Women, Contributing Factors, and its Effects on Psychological Resilience: An Evaluation of Women in Turkey
Orhan, İ.; Ünal, E.; Ağralı, C.; Küçükkelepçe, D.Ş.
Background: Violence by intimate partners is a serious public health problem that negatively affects women’s physical, emotional, and social well-being. In Turkey, factors such as traditional gender roles, economic inequalities, and cultural norms contribute to the continuation of this form of violence. Understanding how such experiences influence women’s psychological strength is essential for effective support and prevention strategies. Aim: This study aims to determine the relationship between domestic violence against women, the factors affecting it, and levels of psychological resilience among women in Turkey. Patients and Methods: We conducted this research with 425 women residing in Tunceli, Turkey. In this cross-sectional, relational study, data were collected using a personal information form, the Violence Against Women Scale (SVAWS), and the Brief Resilience Scale (BRS). The relationship between scores obtained from the scales was determined through correlation and linear regression analyses. Cronbach’s alpha coefficient was calculated to assess the reliability of the scales. Results: The average age of the women who participated in the study was 41.22 ± 12.93 years. Approximately one in four women (24.5%) experienced violence, with the primary reasons for violence being financial problems (40.4%) and issues caused by family members of the couple (28.8%). A significant negative correlation was found between the SVAWS and BRS scores (r = −0.228, P < 0.01). Additionally, there was a significant negative relationship between all subdimensions of the violence scale and psychological resilience. Conclusion: The study found that as the level of violence experienced by women increased, their level of psychological resilience decreased.
- MakaleAçık Erişim2025Scopus SJRQ1Effect of neuro-linguistic programming on comfort after cesarean: a randomized controlled trial neuro-linguistic programming comfort level cesarean
Doğan, Aysel; Dal, Nursel Alp; Beydag, Kerime Derya
Background: Due to the deterioration in comfort experienced after cesarean section, mothers go through troubled hours, have problems with breastfeeding, and cannot even meet their own and their baby’s needs. This study was conducted to determine the effect of neuro-linguistic programming on mothers’ comfort levels following cesarean section in the postpartum period. Methods: This study was performed from 1 January to 1 September 2023 as a prospective randomized controlled single-blind clinical trial with 100 participants (50 experimental, 50 control). The research data were collected using the Personal Information Form and the Postpartum Comfort Scale. The dependent samples t test and independent samples t test were used in the analysis of research data as well as numbers, percentages, and means. Analysis of covariance (ANCOVA) was used to evaluate the effect of the NLP more accurately by controlling the pre-test scores. Results: There were statistically significant differences between the mean pretest and posttest postpartum comfort scale scores, physical comfort scores, psycho-spiritual comfort scores, and sociocultural comfort scores of mothers in the intervention group. In this regard, mothers in the intervention group had higher mean postpartum comfort scale scores, physical comfort scores, psycho-spiritual comfort scores, and sociocultural comfort scores in the posttest phase than in the pretest phase. Conclusions: This study revealed that neuro-linguistic programming enhanced the postpartum comfort levels of mothers who underwent cesarean delivery. In this context, it is recommended that nurses and midwives enhance participants’ comfort through the use of neuro-linguistic programming techniques in care processes. Trial registration: NCT05646537.
AtıfScopus3WoS2OpenAlex2
İncele - MakaleYayıncıda açık erişim2025Scopus SJRQ1Effect of postharvest melatonin and salicylic acid applications on quality characteristics and primary and secondary metabolite physiology of tomato fruits
Kaygısız, Tansel; Sen, Fatih; Gundogdu, Muttalip; Ejaz, Shaghef; Aglar, Erdal
Background: This study aims to investigate the effects of postharvest melatonin (ML) and salicylic acid (SA) applications on fruit quality and biochemical properties in tomatoes. The potential synergistic effects were investigated by applying these compounds to the ‘Depar’ tomato variety grown in Bolu in the 2024 production season. The tomato fruit that were mature and free from physical damage were selected and sterilized according to predetermined criteria. Afterwards, ML and SA solutions (1 mM) were sprayed on each fruit and then the fruit were stored at 5 ± 0.5 °C and 90 ± 5% relative humidity. Pomological and biochemical measurements and analyses were carried out on fruit stored for 24 days in three different periods (8th, 16th and 24th days). Results: With the extension of storage period, the increase in spoilage and ripening symptoms such as weight loss (8.53%), pH increase (5.01) and soluble solids content (SSC) accumulation (4.95%) was observed in tomatoes. In addition, the significant decreases occurred in malic acid, citric acid, tartaric acid, oxalic acid, vitamin C and phenolic compounds. However, SA and ML applications slowed down these negative changes, with the best results generally obtained in the SA + ML combination. This combination significantly limited the decreases in weight loss and chemical contents, delayed the ripening of tomatoes and maintained their nutritional value. Especially in early and middle storage periods (8th and 16th days of the cold storage), SA + ML applications gave the most effective results. However, some protective effects were reduced by the 24th day the cold storage. Conclusion: SA and ML applications are recommended as an effective biopreservation strategy to extend the shelf life of tomatoes, prevent commercial value loss and maintain quality. This study demonstrates the potential of using bioactive compounds to preserve the quality and nutritional values of tomatoes after harvest.
AtıfScopus10OpenAlex12İncele - MakaleYalnız künye2025Scopus SJRQ2The Trends and Hotspots of Research on Adolescent Pregnancy: A Bibliometric Analysis
Pehlivanoğlu, Şeyma; Çelik, Osman Tayyar; Tok, Yasin; Sağlam, Mehmet
This bibliometric study aims to contribute to the literature on adolescent pregnancy by exploring gaps, research trends, contributing countries and journals, collaboration networks, and subject themes, offering a macro perspective on the field’s development and future directions. This study employed a bibliometric research methodology. Publications containing the keywords adolescent, adolescence, youth, teenager, puberty, juvenile, pregnancy, and pregnant were retrieved from the Web of Science (WoS) database (1980–April 24, 2024) and analyzed using VOSviewer and the open-source R bibliometric package, adhering to predefined inclusion/exclusion criteria. The concept of adolescent pregnancy has been studied annually from 1980 to the present, peaking in 2022. Key research topics include sexual and reproductive health, contraception, and depression. According to Lotka’s Law, 84.7% of authors in this field have published only once. Recent studies have focused on birth weight and pregnancy risks. The most cited publication globally and locally is by Ganchimeg et al., while the Journal of Adolescent Health is the most productive platform. The United States, Brazil, the United Kingdom, South Africa, Canada, and Turkey are the most productive countries in this field. The results of this study highlight that adolescent pregnancy remains a global public health issue, as evidenced by its consistent presence in annual research. Key research gaps and trends include social and emotional challenges faced by pregnant adolescents, physical development and health during adolescent pregnancy, causes and prevalence trends, preventive education services, and psychosocial interventions. Further research is essential to develop effective interventions for preventing adolescent pregnancy and safeguarding the best interests of children.
AtıfScopus3WoS3OpenAlex4İncele - MakaleAçık Erişim2025Scopus SJRQ2HASK-Net: new hybrid attention selective kernel network for automatic colon cancer detection from colonoscopy images
Imak, Andaç; Doğan, Gürkan; Sengur, Abdulkadir; Ergen, Burhan
Colorectal cancer is a frequently analyzed cancer type seen today. It is the third leading of cancer in terms of incidence. It is among the second leading cases resulting in death. However, when detecting pre-cancerous polyps using traditional methods, the rate of being overlooked is high. Therefore, the rate of missed polyps can be greatly reduced with deep learning-based computer-aided diagnosis (CADx) methods. In this study, a novel convolutional neural network based on CADx, called HASK-Net, is proposed for automatic polyp detection. While HASK-Net uses ResNet50 as a feature extractor in the encoder network, the novely designed hybrid attention selective kernel convolution uses it in the decoder network to increase the representation power in feature maps and learn more complex features. In experimental results on the publicly available Hiper-Kvasir and EndoTech 2020 benchmark datasets, HASK-Net showed extremely promising performance with a dice similarity score of 97.02% and 84.83% and an mIoU score of 95.38% and 84.32%, respectively.
- MakaleAçık Erişim2025Scopus SJRQ1Green Synthesis of Multi-Walled Carbon Nanotube-Reinforced Hydroxyapatite Doped with Silver and Silver-Core Selenium-Shell Nanoparticles: Synthesis, Characterization, and Biological Activity
Unal, İlkay
Hydroxyapatite (HAp) is widely used in biomedical applications due to its biocompatibility, osteoconductivity, and bioactivity. However, its low mechanical strength, tendency toward rapid corrosion, and lack of bactericidal properties present significant limitations in applications. This study aimed to improve the properties of HAp by reinforcing it with multi-walled carbon nanotubes (MWCNTs) and doping it with silver nanoparticles (AgNPs) and silver-core selenium-shell nanoparticles (Ag@SeNPs). Ocimum basilicum extract was used as both a reducing and stabilizing agent in the synthesis of nanoparticles using an environmentally friendly and non-toxic method as an alternative to traditional methods. The synthesized HAp, HAp/MWCNT, Ag-HAp/MWCNT, and Ag@Se-HAp/MWCNT nanocomposites were characterized by TEM, SEM, XRD, Raman spectroscopy, and BET analysis. BET analysis showed a reduction in surface area from 109.4 m2/g for pure HAp to 71.4 m2/g, 47.5 m2/g, and 35.3 m2/g for HAp/MWCNTs, Ag- HAp/MWCNTs, and Ag@Se-HAp/MWCNTs, respectively. Antimicrobial activities against P. aeruginosa, E. coli, S. aureus, E. faecalis, and C. albicans were evaluated. HAp and HAp/MWCNT did not show any antimicrobial activity, while Ag-HAp/MWCNTs showed inhibition zones of 14 mm for Escherichia coli and 18 mm for Pseudomonas aeruginosa at 5 mg/mL. Ag@Se-MWCNTs/HAp exhibited superior efficacy with inhibition zones of 18 mm, 12 mm, and 20 mm for S. aureus, E. faecalis, and Candida albicans, respectively. The incorporation of Ag@SeNPs enhanced HAp’s antibacterial and antifungal properties through a synergistic mechanism.
AtıfScopus12WoS10OpenAlex12İncele - MakaleAçık Erişim2025Scopus SJRQ1The effect of motivational interviewing on healthy lifestyle behaviors and quality of life in on menopausal women: a pilot randomized controlled trial
Orhan, İlksen; Yağmur, Yurdagül
Background: This study aims to determine the effect of motivational interviewing (MI), an effective communication technique, on healthy lifestyle behaviors and quality of life in menopausal women. Methods: This is a randomized controlled empirical study. The study was conducted with a total of 136 women, including 68 for experimental group and 68 for control group. The data were collected using an introductory information form, the Health Promoting Lifestyle Profile II (HPLPL II) and the Menopause-Specific Quality of Life (MENQOL). Women in the experimental group received 6 sessions of motivational interviewing and 2 follow-up interviews in two family health centers (FHCs) from the researcher. No intervention was applied to women in the control group. The data were analyzed using number, percentage, mean, standard deviation, chi-square test, Bonferroni test, independent samples t test and repeated ANOVA. Results: There was a statistically significant difference between the HPLPL II total scale and health responsibility, nutrition, spiritual development, interpersonal relationships, and stress management subscales pre-test, interim test and post-test mean scores of women in the experimental group, and their mean scores increased positively (p < 0.001). In addition, a statistically significant difference was also found between their MENQOL vasomotor, psychosocial, physical and sexual domains pre-test, mid-test and post-test mean scores (p < 0.05). Conclusion: Motivational interviewing was found to be effective in increasing healthy lifestyle behaviors and quality of life in menopausal women. Trial registration: Current Controlled Trials NCT06802458, 17/01/2025 (https//clinicaltrials.gov/study/NCT06802458), “Retrospectively registered”.
AtıfScopus3WoS3OpenAlex4İncele - MakaleAçık Erişim2025Scopus SJRQ1Maximal strength, sprint and jump performance in elite kumite karatekas
Cinarli, Fahri Safa; Aydogdu, Onur; Aydin, Yalcin; Tokgöz, Gürkan; Kahraman, Abdulselam; Beykumül, Ayşegül; Aygoren, Caner; Yılmaz, Nurkan; Ramirez-Campillo, Rodrigo
Background: Both maximal muscle strength and muscle power are independently important for karatekas. However, the relationship between strength and power in elite male kumite karatekas is under researched. This study aimed to determine the relationship between back-leg-chest (BLC) isometric muscle strength with sprint and jump variables in elite male karatekas. Methods: Male elite/international level (tier 4) kumite karatekas (n = 14; age, 20.79 ± 1.67 year; height, 1.77 ± 0.06 m; weight, 72.21 ± 5.20 kg) were recruited. BLC strength, sprint and jump values were measured with a dynamometer, a photocell, and an application, respectively. Pearson correlation (trivial r < 0.1; small r < 0.3; moderate r < 0.5; large r < 0.7; very large r < 0.9; nearly perfect/perfect r ≥ 0.9) and linear regression analyses were performed to determine the relationship and shared variance between BLC strength, sprint, and jump performance. Results: There were large to very large correlations between BLC strength and sprint time (r = − 0.930, p < 0.01), velocity (r = 0.918; p < 0.01), acceleration (r = 0.913; p < 0.01) and running momentum (r = 0.721; p < 0.01). Additionally, BLC strength correlated with jump height (moderate, r = 0.550, p < 0.05), peak anaerobic power (moderate, r = 0.672, p < 0.01) and power to body mass ratio (moderate, r = 0.545, p < 0.05). BLC strength and sprint variables showed an r2 = 0.52–0.86 (p < 0.01), while BLC strength and jump variables showed an r2 = 0.29–0.45 (p < 0.05). Conclusions: BLC strength is related to jump and sprint performance in male elite karate athletes. This relationship underscores the importance of including strength training that targets BLC muscle strength in training programs for coaches and athletes.
AtıfScopus6İncele - MakaleAçık Erişim2025Scopus SJRQ1ADAMTS-1, a multifunctional proteinase, in the uterus of both estrous cycle rats and ovariectomized rats can be regulated via hormones
Parlak Ak, Tuba; Yaman, Mine; Bayrakdar, Ali; Bulmus, Ozgur
Remodeling of the extracellular matrix (ECM) throughout the estrous cycle is one of the most striking features of the uterus. A disintegrin and metalloprotease with thrombospondin type I motifs (ADAMTS-1) is a metalloproteinase responsible for the degradation of some proteoglycans, which are ECM components. In this study, ADAMTS-1 distribution was analyzed in the uterus of ovariectomized rats administered 17β-estradiol (E2) and progesterone (P4) and in the uterus at different estrous stages. Ovariectomized (OVX) rats were subjected to single and combined E2 (0.2 mg/kg) and P4 (10 mg/kg) hormone replacement therapies. E2 was administered for 3 consecutive days, followed by E2, P4, or E2 + P4 for 4 consecutive days. The serum level of E2 decreased from the proestrus phase to the diestrus phase, but that of P4 was the highest in the estrus phase. During the estrus phase, the serum level of luteinizing hormone (LH) was the lowest and that of follicle-stimulating hormone (FSH) was the highest. P4 level increased significantly in the OVX + P4 and OVX + E2 + P4 groups compared with the OVX group. The serum levels of LH and FSH decreased in the OVX + E2 and OVX + P4 groups compared with the OVX group, and were the lowest in the OVX + E2 + P4 group. ADAMTS-1 immunoreactivity in luminal, glandular, and stromal cells of the uterus decreased from proestrus to diestrus. When immunoreactivity in hormone replacement groups was compared, weak immunoreactivity was observed in the OVX group. ADAMTS-1 immunoreactivity gradually increased in OVX + P4 and OVX + E2 groups, and was particularly notable in luminal, glandular, and stromal cells in the OVX + E2 + P4 group. ADAMTS-1 distribution was affected by the estrous cycle process and hormone replacement therapy in the OVX procedure.
AtıfScopus1OpenAlex1İncele - MakaleAçık Erişim2025Scopus SJRQ2Determination of cardiometabolic risk in pre- and post-menopausal women
Orhan, İlksen; Koçak, Hatice Serap; Kaplan, Emine
Objective: The study was designed to determine and compare the cardiometabolic risk in premenopausal and postmenopausal women. Methods: Data were collected using cross-sectional and correlational study. In this study, the sociodemographic characteristics, anthropometric measurements, and biochemical parameters of menopausal women were examined. Results: The average age of menopausal women is higher compared to premenopausal women. Menopausal duration, number of children, daily cigarette consumption, body weight, body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio, systolic and diastolic blood pressure, fasting blood glucose, hemoglobin, AST (aspartate aminotransferase), and Framingham risk score are higher in menopausal women compared to premenopausal women. Conversely, height, HDL (high-density lipoprotein) level, LDL (low-density lipoprotein) level, TSH (thyroid-stimulating hormone), ALT (alanine aminotransferase), HbA1c (glycated hemoglobin), serum albumin, and visceral adiposity index (VAI) values are lower in menopausal women compared to premenopausal women. Conclusion: These findings indicate changes in the metabolic profiles of menopausal women. This study could serve as an important resource for assessing the health status of menopausal women and for implementing appropriate measures. Clinical trial number: not applicable.
AtıfScopus4WoS4OpenAlex5İncele - MakaleAçık Erişim2025Scopus SJRQ1Effects of inspiratory muscle training on physical fitness in cystic fibrosis: a systematic review and meta-analysis
Aksel-Uylar, Aydan Asli; Topcuoglu, Ceyhun; Saglam, Melda; Vardar-Yagli, Naciye
Background: Cystic fibrosis (CF) is a multisystem disease primarily affecting the lungs. It impacts physical fitness due to increased bronchial secretions and exercise intolerance. Inspiratory muscle training (IMT) is recommended as a pulmonary rehabilitation approach. Therefore, we aimed to examine the effect of inspiratory muscle training on health-related physical fitness in CF. Methods: Articles were searched in five databases from inception to June 2025. All randomized controlled trials comparing IMT with a control group in individuals with cystic fibrosis were included. Four randomized controlled trials involving a total of 90 individuals with CF met the inclusion criteria. Results: A significant difference was found in the change in maximal work capacity, maximal minute ventilation, and exercise duration during the exercise test in the IMT group compared to the control group. However, no significant difference was observed in the change in maximal oxygen uptake, 6-minute walk test distance, and oxygen saturation during the 6-minute walk test between the IMT group and the control group. Conclusion: The therapeutic effectiveness of IMT for physical fitness is still uncertain. The evidence is not enough to assess how IMT can be used to enhance health-related physical fitness in CF. Further research should explore the optimal intensity and duration of IMT training needed to improve cardiorespiratory fitness. Additionally, future studies should evaluate how effective IMT is when examining its impact on health-related physical fitness.
- MakaleYalnız künye2025Scopus SJRQ2The Relationship Between Employment Guilt and Psychological Resilience Levels of Working Mothers
Orhan, İlksen; Ünal, Esra; Ağralı, Cansu
Psychological resilience is a significant factor affecting feelings of guilt, as it helps mothers maintain a better balance between work and family responsibilities. This study was conducted to identify the relationship between employment guilt and the psychological resilience levels of working mothers. The research involved 483 working mothers residing in Osmaniye province, Turkey, who were employed in various fields. In this cross-sectional correlational study, data were collected online via Google Forms using the Personal Information Form, the Maternal Employment Guilt Scale, and the Brief Resilience Scale. The results of this study suggest that as the psychological resilience levels of working mothers increased, their employment guilt levels decreased. The results from this research can be used to identify potential interventions that could mitigate the negative effects of employment guilt on psychological resilience.
AtıfScopus4WoS4OpenAlex5İncele - MakaleAçık Erişim2025Scopus SJRQ3Sexually transmitted diseases-related knowledge levels of midwifery students studying at two different universities: A comparative study
Yeşiltepe, Akgün; Ulucan, Mihriban; Akan, Ayşenur; Can, Hafize Öztürk
This study aimed to compare the knowledge levels of midwifery students from two universities in eastern and western Turkey regarding sexually transmitted diseases (STDs). A descriptive, comparative study was conducted with midwifery students from both regions.The average score on the STD Knowledge Test was 14.49±3.83. Students from the western university scored 14.63±3.60, while those from the eastern university scored 13.98±4.58. Among western university students, knowledge scores were significantly associated with factors such as year of study, place of residence, and prior sexual health education. For eastern university students, significant factors included age, year of study, social security status, and university-based sexual health education (p<0.05). It is recommended that educational programs be strengthened to enhance students' knowledge and improve access to accurate, reliable information. African Journal of Reproductive Health © 2025.; L'étude visait à comparer les niveaux de connaissance des étudiants sages-femmes de deux universités situées l'est et à l'ouest de la Turquie sur les maladies sexuellement transmissibles. Cette étude descriptive et comparative a été menée auprès d'étudiants des départements de sages-femmes de deux universités différentes situées dans les régions de l'est et de l'ouest de la Turquie. Le score moyen obtenu par le test de connaissances sur les maladies sexuellement transmissibles était de 14,49±3,83. Alors que le score moyen obtenu par « les participants fréquentant l'université de l'ouest de la Turquie était de 14.63±3.60, le score moyen obtenu par » les participants fréquentant l'université de l'est de la Turquie était de 13.98±4.58. Alors qu'il y avait une relation statistiquement significative entre les scores moyens obtenus au test de connaissance des maladies sexuellement transmissibles par les étudiants de l'université de l'ouest et les variables telles que l'année scolaire, le lieu de résidence, l'éducation à la santé sexuelle au lycée, l'éducation à la santé sexuelle à l'université, et la connaissance des maladies sexuellement transmissibles, il y avait une relation statistiquement significative entre les scores moyens obtenus à la même échelle par les étudiants de l'université de l'est et les variables telles que l'âge, l'année scolaire, la sécurité sociale, l'éducation à la santé sexuelle à l'université (p˂0,05). Le niveau de connaissance des étudiants sur les maladies sexuellement transmissibles est insuffisant; il est donc recommandé que les étudiants participent à des activités éducatives pour améliorer leur niveau de connaissance sur les maladies sexuellement transmissibles et pour leur permettre d'accéder à des sources précises et fiables.
- MakaleYalnız künye2025Scopus SJRQ3In Vitro Control of Anisakis Larvae Using Nanoemulsified Thyme, Garlic, and Grape Seed Essential Oils Combined with Brines
Cadun, Aslı; Pekmezci, Gökmen Zafer; Şen Yılmaz, Evren Burcu; Bulat, Fevziye Nihan; Demirtaş, Nida; Çaklı, Atilla; Inci, Abdullah; Yıldırım, Alparslan; Karademir, Gupse Kübra; Erdem, Omer Alper
Introduction: Anisakiasis is a zoonotic parasitic disease transmitted through consumption of fish, with increasing global cases. While thorough cooking kills Anisakis larvae, thermo-stable allergens can still cause allergic reactions. Traditional Mediterranean seafood methods such as marinating, salting, and brining, which lack heat treatment, pose a high risk of anisakiasis. Materials and methods: This study investigated the antilarval effects of nanoemulsions made from thyme, garlic, and grape seed essential oils combined with brines on Anisakis L3 larvae in vitro. Results: Larvae were collected from mackerel, chub mackerel, anchovy, horse mackerel, and sardine, with 1746 larvae examined, mostly Anisakis type I and molecularly identified as A. pegreffii. Thyme oil’s main components, carvacrol and thymol, showed strong antimicrobial and antioxidant effects and superior larvicidal activity at lower doses compared to garlic and grape seed oils. Garlic oil, rich in organosulfur compounds, was more effective in Lakerda samples. High salt brine alone inactivated larvae within 24 h. The thyme oil nanoemulsion had droplet sizes below 90 nm, enhancing stability, whereas garlic and grape seed oils had larger droplets. Conclusion: These results indicate that nanoemulsified essential oils, especially thyme oil, are promising natural agents to control Anisakis larvae in traditional sea-food products.
- MakaleAçık Erişim2025Scopus SJRQ1Impacts of methyl jasmonate treatments on quality properties and bioactive compounds of jujube fruit (Ziziphus jujuba) during cold storage
Ozturk, Burhan; Karakaya, Orhan; Aglar, Erdal; Hancı, Mehmet Utku; Ozturk, Ahmet; Asghari, Mohammadreza
Background: Jujube is an important fruit species due to its high nutritional value and health benefits. However, the short shelf life of fruit causes quality losses, making it difficult to trade. This study was conducted to determine the effects of postharvest methyl jasmonate (MeJA) applications on the fruit quality and biochemical properties of ‘Li’ jujube (Ziziphus jujuba Mill.) cultivar. In the study, fruits were pre-cooled at 7 °C and 85 ± 5% humidity for 24 h and those with diseases, pests, and mechanical damage were eliminated. Then, MeJA was applied to the fruits at concentrations of 0.2 mM and 0.4 mM and stored at 0 ± 0.5 °C and 90 ± 5% humidity for 45 days and analyzes were performed at 15-day intervals. Results: This study showed that MeJA applications positively affected the postharvest quality of jujube fruit. MeJA-applied fruits exhibited lower weight loss and lower respiration rates, and MeJA applications helped preserve fruit color and maintained fruit firmness for a longer time. MeJA was effective in maintaining the total phenolic and flavonoid content in fruit content and the loss of vitamin C content was lower with MeJA application. MeJA was effective for determining soluble solids content (SSC), and titratable acidity and delayed ripening in fruit. Conclussion: MeJA application increases the commercial value of fruits by reducing weight loss, slowing down the ripening process, and preserving higher nutritional content and antioxidant activities and suggest that it can be used as a feasible method for improving fruit protection strategies. MeJA application stands out as an effective method for extending the shelf life of jujube fruits by preserving their post-harvest quality and nutritional values.
AtıfScopus7OpenAlex6İncele - MakaleAçık Erişim2025Scopus SJRQ3Gynaecological cancer awareness and healthy lifestyle behaviors of women aged 20-65 years: A descriptive cross-sectional study
Yaşar, Beril Nisa; Şeker, Sevda Arslan
For both individual and community health, women's health is vital. In particular, gynecological cancers can be prevented or treated by adopting healthy lifestyles, raising awareness, and detecting them early. This study aimed to identify levels of gynecological cancer awareness and healthy lifestyle behaviors among women aged 20-65 years. There were 251 women in the descriptive cross-sectional study. The Gynecological Cancers Awareness Scale (GCAS), the Descriptive Characteristics Form, and the Healthy Lifestyle Behavior Scale-II (HLBS-II) were used to gather data. The data was analyzed using the Pearson's correlation test, multiple linear regression, and descriptive statistics. The average HLBS-II score was 123.53±20.75, while the average GCAS score was 149.64±21.30. The HLBS-II and GCAS scores showed a statistically significant positive correlation. Women knowledgeable about early diagnosis methods scored 10.758 times higher on the GCAS, while women familiar with vulvar self-examination scored 11.016 times higher. Employed women had a mean HLBS-II score 6.124 times higher than non-employed women (p<0.05). Women's awareness of gynecological cancer was high, but they also had moderately good lifestyle choices. To raise awareness and promote healthy lifestyle choices, healthcare professionals are advised to take part in health-promoting initiatives.
AtıfScopus2WoS2OpenAlex2İncele - MakaleAçık Erişim2025Scopus SJRQ2Exploration of UHPLC-ESI-QTOF-MS Profiles and the Neuroprotective, Antidiabetic, Antioxidant and Cytotoxic Effects of Extracts from Achillea maritima (L.) Ehrend. & Y.P.Guo (Asteraceae) Collected in Türkiye
Ahmed, Shakeel; Zengin, Gokhan; Fernández-Ochoa, Álvaro; de la Luz Cádiz-Gurrea, Maria; Leyva-Jiménez, Francisco Javier; Elkiran, Omer; Cakilcioglu, Ugur; Akgul, Bengusu H.; Pereira, Catarina G.; Custódio, Luísa
The current study investigated the chemical composition, antioxidant activity, enzyme inhibition, and cytotoxic activities of extracts from Achillea maritima, a wild medicinal plant used for various therapeutic purposes. The antioxidant activities were assayed through different assays like DPPH, ABTS, CUPRAC, FRAP, and phosphomolybdenum, whereas in enzyme inhibition studies, cholinesterase, tyrosinase, α-amylase, and α-glucosidase were assayed. Cytotoxicity studies are conducted on S17, RAW, and HepG2 to assess its selectivity and effectiveness. Chemical profiling by UHPLC-ESI-QTOF-MS revealed multiple bioactive compounds in the extracts. Polar solvents (ethanol, ethanol/water, and water) resulted in high concentrations of phenolic acids as well as chlorogenic and caffeoylquinic acids, as well as flavonoids like vicenin and apigenin. On the other, the nonpolar (hexane extract) was rich in octadecatrienoic acid hydroperoxy and hydroxyoctadecatrienic acid. Among these, the water extract contained the highest phenolic content of 32.26 mg GAE/g, while the ethyl acetate extract was the richest in flavonoids, with 7.83 mg RE/g. In the antioxidant studies, the water and ethanol/water extracts consistently display the most potent activities, thus indicating their significant free radical scavenging and metal chelation abilities. The studies on enzyme inhibitions showed remarkable BChE inhibitory activities of the ethanol extract in 12.50 mg GALAE/g, thus showing potential in managing disease conditions related to cholinesterase. Tyrosinase inhibition was significant by the ethanol extract, presenting 55.59 mg KAE/g. The ethyl acetate extract exhibited the most potent inhibitory activity against α-amylase with 0.66 mmol ACAE/g, while ethanol extract showed significant inhibition of α-glucosidase with 4.35 ACAE/g. Cytotoxicity results showed that the water extract was most effective against the HepG2 cancer cell line by reducing cell viability to 38.4% at high doses while preserving low toxicity against normal cells, as observed by high viability percentages in S17 and RAW cell lines. These results highlight the usefulness of A. maritima extracts in nutraceutical, pharmaceutical, and cosmeceutical applications.
AtıfScopus15İncele - MakaleYalnız künye2025Scopus SJRQ1Patterns and Predictors of Nurse Turnover Intentions Based on Years of Nursing Experience: A Cluster Analysis Approach
Baris, Veysel Karani; Yesiltepe, Akgun; Celik, Gulbahar
Aim: To identify patterns and predictors of nurse turnover intentions based on years of nursing experience using a cluster analysis approach. Background: Nurses with varying years of experience have different characteristics. These differences can also lead to distinct patterns and predictors of turnover intentions. Methods: For this descriptive study, 785 nurses from hospitals across different regions of Türkiye participated in a survey. Data was collected through online questionnaires between April and May 2022. The K-means unsupervised machine learning algorithm was employed to classify nurses into distinct clusters based on their experience. Multiple linear regression analyses were conducted to identify the predictors of turnover intention specific to each cluster. The STROBE guideline was followed for reporting. Results: Cluster analysis grouped nurses into three categories by experience level: low, medium and high. The medium-experience group had the highest turnover intention, whereas the high-experience group had the lowest. Work stress was the only common predictor across all groups. Low income predicted turnover only for the low-experience group, and gender was significant only for the medium-experience group. Conclusion: This study revealed that turnover intention and its predictors vary by experience level, indicating a need for retention strategies tailored to nurses' years of experience. By considering subgroup characteristics, policymakers can develop targeted interventions to enhance nurse retention.
- MakaleAçık Erişim2025Scopus SJRQ1Transauricular vagal nerve stimulation suppresses inflammatory responses in the gut and brain in an inflammatory bowel disease model
Atalar, Kerem; Alim, Ece; Yigman, Zeynep; Belen, Hayrunnisa Bolay; Erten, Fusun; Sahin, Kazım; Soylu, Ayse; Dizakar, Saadet Ozen Akarca; Bahcelioglu, Meltem
Inflammatory bowel disease (IBD) encompasses Crohn's disease (CD) and ulcerative colitis (UC), is a major health problem on a global scale and its treatment is unsatisfactory. We aimed to investigate the effects of transauricular vagal nerve stimulation (tVNS) on inflammation in rats with IBD induced by trinitrobenzene sulfonic acid (TNBS). A total of 36 adult female Sprague–Dawley rats were given TNBS, or vehicle, and tVNS, or sham, every other day for 30 min for 10 days. Postmortem macroscopic and microscopic colon morphology were evaluated by histological staining. Additionally, IL-1β, IL-6, IL-10, and TNF-α cytokine levels in the colon and the brain were evaluated by immunohistochemistry and western blotting analysis. TNBS induced epithelial damage, inflammation, ulceration, and thickened mucosal layer in the colonic tissues. Administration of tVNS significantly ameliorated the severity of TNBS-induced tissue damage and inflammatory response. TNBS also alters pro-inflammatory and anti-inflammatory balance in the brain tissue. TVNS application significantly suppressed the protein levels of pro-inflammatory cytokines, namely IL-1β, IL-6, and TNF- α while augmenting the level of anti-inflammatory cytokine IL-10 in the colonic and the brain tissue. We have shown that TNBS-mediated colonic inflammation and tissue damage are associated with neuroinflammatory responses in the brain tissue. Also demonstrated for the first time that neuroinflammatory response in the gut-brain axis is suppressed by tVNS in the IBD model. Non-invasive tVNS stands out as a new potential treatment option for types of IBD.
AtıfScopus13OpenAlex12İncele - MakaleAçık Erişim2025Scopus SJRQ2Synthesis and characterization of novel bis(thiosemicarbazone) complexes and investigation of their acetylcholinesterase and glutathione S-transferase activities with in silico and in vitro studies
Donmez, Melike; Sekerci, Memet; Adiguzel, Ragip; Oğuz, Ercan; Türkan, Fikret; Yildiko, Umit; Colak, Naki
In this study, firstly, bis(thiosemicarbazone) ligand [L: 2,2′-(2-(2-(4-methoxyphenyl)hydrazineylidene)cyclohexane-1,3-diylidene)bis(hydrazine-1-carbothioamide)] was synthesized by the condensation reaction of thiosemicarbazide and ketone compound (2-(2-(4-methoxyphenyl)hydrazone)cyclohexane-1,3-dione). The metal complexes were synthesized by the reaction of obtained ligand (L) with CuCl2·2H2O, NiCl2·6H2O, CoCl2·6H2O, and MnCl2·4H2O salts. The structures of synthesized ligand and their complexes were characterized using elemental analysis, IR, UV–Vis, 1H-NMR spectra, 13C-NMR spectra, magnetic susceptibility, mass spectra (LC–MS), thermogravimetry analysis-differential thermal analysis (TGA-DTA), and differential scanning calorimetry techniques. According to the results of the analysis, square plane geometry was suggested for Cu and Co complexes. However, the structures of Ni and Mn complexes were in agreement with octahedral geometry. Molecular docking analysis and pharmacological potential of the compound were evaluated to determine the inhibitory potential against acetylcholinesterase (AChE) and Glutathione-S-transferases (GST) enzymes. The compound exhibited strong binding/docking indices of − 5.708 and − 5.928 kcal/mol for the respective receptors. In addition, L–Ni(II) complex was found to be the most effective inhibitor for AChE enzyme with a Ki value of 0.519. However, with a Ki value of 1.119, L–Cu(II) complex was also found to be an effective inhibitor for the GST enzyme.
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