Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Zengin, Gokhan(26)
- Erten, Fusun(20)
- Orhan, Cemal(17)
- Sahin, Kazim(17)
- Gul, Muhammet(15)
- Benzer, Fulya(12)
- Kocabaş, Mehmet(12)
- Aglar, Erdal(11)
- Serdar, Osman(11)
- Akkurt, Nevzat(10)
- Topal, Murat(10)
- Yeşiltepe, Akgün(10)
- Yucesan, Melih(10)
- Danabas, Durali(9)
- Er, Besir(9)
- Kutlu, Banu(9)
- Mahomoodally, Mohamad Fawzi(9)
- Uba, Abdullahi Ibrahim(9)
- Yildirim, Ozal(9)
- Öbek, Erdal(9)
- Acharya, U. Rajendra(8)
- Alp Dal, Nursel(8)
- Cakilcioglu, Ugur(8)
- Kandemir, Fatih Mehmet(8)
- Yildirim, Nuran Cikcikoglu(8)
- Arslan Topal, E. Işıl(7)
- Baloglu, Ulas Baran(7)
- Ozbey, Ulku(7)
- Sahin, Nurhan(7)
- Talo, Muhammed(7)
- Ates, Mehmet(6)
- Attar, Rukset(6)
- Dal, Nursel Alp(6)
- Gümüşsoy, Süreyya(6)
- Gürarslan Baş, Nazan(6)
- Ince, Muharrem(6)
- Kaplan Serin, Emine(6)
- Kutluyer, Filiz(6)
- Ozturk, Burhan(6)
- Aksu, Onder(5)
Yayınlar
- MakaleYalnız künye2024Scopus SJRQ2Seasonal Monitoring of Heavy Metal Pollution in Water and Zebra Mussels Dreissena polymorpha as a Potential Bioindicator Species from Lake Habitat
Kutluyer Kocabaş, Filiz; Başaran, Ertuğrul; Kocabaş, Mehmet
In aquatic ecosystem, metal pollution is an important environmental hazard. Mussels as a bioindicator species are often used for assessment the presence of potentially toxic metals. Hence, the present study aimed to assess the effect of seasonal variations on some heavy metals (Cd, Cr, Pb, As, Zn and Cu) accumulation in water and Dreissena polymorpha from lake habitat. Our result indicated that Zn accumulated at a very high level in the zebra mussels while As accumulated at a high level in water samples. Seasonal variations significantly affected Cu concentration in the water samples (P < 0.05) while Cr concentration in the mussel samples was significantly affected by seasonal variations (P < 0.05). According to the water analysis, mean concentrations of metals are below the maximum limits established by the World Health Organization and USEPA, except As. Overall, our data emphasize anthropogenic pollution in the Turkish aquatic environment and confirm the use of D. polymorpha as a prospective biomonitor for metal polluted sites’.
AtıfScopus3WoS2OpenAlex4
İncele - MakaleAçık Erişim2024Scopus SJRQ3The correlation between children’s health literacy level and healthy eating self-efficacy
Kasimoğlu, Necla; Gürarslan Baş, Nazan
Background The school environment provides an important opportunity for children and educators to develop health education and health literacy the ability to make rational health decisions and identify and determine factors that affect health. The aim of this study is to determine the correlation between health literacy and eating self-efficacy levels of primary school students and the affecting factors. Methods The study was conducted with 486 fourth graders studying in a primary school located in eastern Turkey between September 2021 and June 2022. The data were collected through face-to-face interviews using the Personal Information Form, the Health Literacy for School-Age Children Scale (HLSAC), and the Healthy Eating Self-Efficacy Scale for Children (HESES-C). Data were analyzed by number, percentage, mean, independent samples t-test, non-parametric Mann–Whitney U and Kruskal–Wallis tests, and Pearson’s correlation tests. Results The gender of the students and the education level of their mothers had a statistically significant correlation with their mean HESES-C and HLSAC scores scores (p<0.05). There was a significant negative correlation between the students’ HLSAC and their HESES-C mean scores. Conclusions According to the findings of the study, the students had a moderate level of health literacy and a low level of healthy eating self-efficacy. There was a negative relationship between health literacy levels and healthy eating self-efficacy.
AtıfWoS1OpenAlex1İncele - MakaleYalnız künye2024Scopus SJRQ1Assessment of microplastic contamination in some commercial fishes of the southern Caspian Sea and its potential risks
Gholizadeh, Mohammad; Bagheri, Tahereh; Harsij, Mohammad; Danabas, Durali; Zakeri, Mohammad; Siddique, Mohammad Abdul Momin
This study examined the occurrence of microplastics (MPs) in the gastrointestinal tract (GIT) of 384 fishes classified into four species from 11 sites in 2022 from the southern part of the Caspian Sea. GITs of fishes were collected and digested in H2O2 and KOH at 45 °C for 72 h. After filtration, extracted MPs were observed under a stereomicroscope, and selected MP particles were identified using FTIR. Presence of MPs was 68.98% in the GIT of the investigated fish. The mean abundance of MPs was 5.9 ± 0.9 MPs/GIT in Rutilus kutum, 9.2 ± 1.2 MPs/GIT in Chelon auratus, 3.6 ± 0.7 MPs/GIT in Alosa braschnikowi, and 2.7 ± 0.5 MPs/GIT in Vimba vimba. The predominant form of MPs was fiber (58.21%), followed by fragment (34.77%). Black (34.4%), white (19.07%), and blue (14.58%) were the most frequently detected colors of MPs. Overall, 6 MP polymers were identified, dominantly polypropylene (42.86%), polystyrene (17.86%), and cellophane (14.28%). The western part of the Caspian Sea (mostly tourist spots and urban areas) showed more MP pollution in fish compared to the eastern part. Polymer hazard index (PHI) revealed alarming microplastic contamination in the southern Caspian Sea. The PHI value of the present study showed that PES (PHI = 8403.78) and PS (PHI = 535.80) were “Extreme danger” and “Danger” risk categories, respectively.
AtıfScopus29OpenAlex34İncele - MakaleYalnız künye2024Scopus SJRQ1Synthesis, characterization and application of cross-linked functional terpolymer through epoxy group as sorbent for extraction of cadmium from waters and foods: Multivariate optimization
Yılmaz, Ersen; Boztuğ, Ali; Ul Haq, Hameed; Boczkaj, Grzegorz; Altunay, Nail
The purpose of this study was to develop a selective sorbent for cadmium ions (Cd(II)) enrichment in orbital shaker assisted solid phase microextraction (OS-SPME) from different aqueous and food samples. A maleic anhydride-styrene-glycidyl methacrylate (MA-St-GMA) terpolymer was synthesized and characterized in detail. Experimental variables of sample preparation step were optimized using a central composite design (CCD). The final determination step was performed using flame atomic absorption spectroscopy (FAAS). The MA-St-GMA sorbent exhibited a high adsorption capacity (195.9 mg g−1) for the Cd(II) ion. The developed method under optimal conditions provides satisfactory performance and a significant improvement compared to other protocols available in the literature. The linear range and detection limit of the method is 0.1–130 ng mL−1 and 0.03 ng mL−1, respectively. The robustness, intraday/interday precision, selectivity, and accuracy of the method were investigated. To further validate the method, a dedicated series of analysis was performed using certified reference materials (CRMs). This part of the study confirmed the applicability of the method for routine analysis. The OS-SPME-FAAS method was validated using water and food samples. Relative standard deviations and recovery for real-world samples were in ranges 1.7–2.2 % and 95.5–98.5 %, respectively. As a result, the MA-St-GMA sorbent showed that it could quantitatively extract Cd(II) ions from aqueous solution.
AtıfScopus9WoS8OpenAlex9İncele - MakaleYalnız künye2024Scopus SJRQ3Assessing the Chemical Composition, Antioxidant and enzyme Inhibitory Effects of Pentapleura subulifera and Cyclotrichium glabrescens Extracts
Nilofar, Nilofar; Zengin, Gokhan; Acar, Mikail; Bouyayha, Abdelhakim; Youssra, Aalilou; Eldahshan, Omayma; Fayez, Shaimaa; Fahmy, Nouran
The Lamiaceae family, encompassing diverse plant species, holds significant value in food, medicine, and cosmetics. Within this family, Pentapleura subulifera and Cyclotrichium glabrescens, relatively unexplored species, were investigated for their chemical composition, antioxidant capacity, and enzyme-inhibiting effects. The chemical composition of hexane, methanolic, and aqueous extracts from P. subulifera and C. glabrescens were analyzed using LC-ESI-MS/MS and the non-polar hexane fraction was investigated via GC-MS. The antioxidant potential of the extracts was determined through radical scavenging, reducing power and metal chelating assays. Additionally, inhibitory activity against six enzymes – acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, amylase, and glucosidase – was examined. The aqueous extract of P. subulifera and the methanolic extract of C. glabrescens exhibited elevated phenolic content at 129.47 mg gallic acid equivalent (GAE)/g and 55.97 mg GAE/g, respectively. Chemical profiling of the constituents of the two plant species resulted in the identification of a total of twenty compounds. The majority of which belonged to flavonoids and quinic acid derivatives, primarily concentrated in the methanol and aqueous extracts. Among all antioxidant assays, the aqueous extracts of P. subulifera demonstrated superior antioxidant activity, with the highest recorded activity of 404.93 mg trolox equivalent (TE)/g in the cupric reducing antioxidant capacity (CUPRAC) test. Meanwhile, the hexane extract of C. glabrescens exhibited the highest AChE inhibitory activity at 2.71 mg galanthamine equivalent (GALAE)/g, followed by the methanol extract of P. subulifera at 2.41 mg GALAE/g. These findings unequivocally establish the notable antioxidant and enzyme inhibitory activity of P. subulifera and C. glabrescens extracts, underscoring their potential as a source of valuable natural antioxidants.
AtıfScopus15OpenAlex14İncele - MakaleYalnız künye2024Scopus SJRQ2Insight into novel inhibitors from Sterculia urens against Cholera via pharmacoinformatics and molecular dynamics simulation approaches
Rahman, M. Oliur; Ahmed, Sheikh Sunzid; Alqahtani, Ali S.; Cakilcioğlu, Uğur; Akbar, Mohammad Ahsanul
The underdeveloped countries with large populations are facing a grave global threat in the form of cholera. Vibrio cholerae, the etiologic agent of Cholera has drawn attention recently due to antimicrobial resistance and resulting outbreaks that necessitates establishment of novel medications to counteract virulence and viability of the pathogen. Sterculia urens Roxb. (Malvaceae) is an ethnomedicinally important tree, which harbors a good number of bioactive phytocompounds. In the present study, 53 phytocompounds of S. urens were screened against the promising target ToxT of V. cholerae employing structure-based drug design approach that revealed three lead compounds, viz., 4,4,5,8-Tetramethylchroman-2-ol (−8.2 kcal/mol), Beta-Bisabolol (−8.2 kcal/mol) and Ledol (−8.7 kcal/mol) with satisfactory ADMET properties. Molecular dynamics simulation for 150 ns unveiled notable compactness and structural stability for the lead compounds considering RMSD, RMSF, Rg, MolSA, PSA and protein-ligand contacts parameters. Molecular mechanics-based MM/GBSA binding energy calculation revealed Beta-Bisabolol (−66.74 kcal/mol) to have better scores than 4,4,5,8-Tetramethylchroman-2-ol (−47.42 kcal/mol) and Ledol (−65.79 kcal/mol). Enzymes were mostly found as drug target class, and Nabilone was found as a structurally similar analog for 4,4,5,8-Tetramethylchroman-2-ol. These discoveries could aid in revealing new antibacterial medications targeting ToxT to combat Cholera. Communicated by Ramaswamy H. Sarma.
AtıfScopus8OpenAlex8İncele - MakaleAçık Erişim2024Scopus SJRQ1Novel formulations ameliorate osteoarthritis in rats by inhibiting inflammation and oxidative stress
Erten, Fusun; Ozdemir, Oguzhan; Tokmak, Muhammed; Durmus, Ali Said; Ozercan, Ibrahim Hanifi; Morde, Abhijeet; Padigaru, Muralidhara; Sahin, Kazim
The study tested new oral plant-based formulations (F) on rats with monosodium iodoacetate (MIA)-induced osteoarthritis, measuring inflammation, antioxidant levels, paw size, stride, and analyzing knee joint images. Fifty-six female Sprague Dawley rats were allocated into 8 groups: (1) Control, (2) MIA (OA induced with MIA), (3) MIA + F1 [curcuminoids+gingerols+acetyl-11-keto-β boswellic acid (AKBA)], (4) MIA + F2 (curcuminoids+Withania glycosides+AKBA), (5) MIA + F3 (curcuminoids+total withanolides+AKBA), (6) MIA + F4 (curcuminoids, AKBA), (7) MIA + UCII (type II collagen), and (8) MIA + GCHON (Glucosamine Chondroitin). Treatments F1 to F4 reduced right joint diameter and improved stride length and paw area in OA rats. Despite improvements with treatments F1 to F4, there was no significant difference between these groups (p >.05). In OA animals, F1 to F4 treatments decreased MDA levels and increased antioxidant enzymes activities (p <.001). This was done by reducing levels of inflammatory markers and enzymes like IL-1β, IL-6, MMP-8, TNF-α, CRP, COMP, and LOX-5, while increasing the anti-inflammatory cytokine IL-10. In conclusion, these plant-based treatments significantly reduced osteoarthritis severity, slowed disease progression by reducing inflammation, and protected joints from damage, showing a protective effect in rats with induced osteoarthritis, likely due to their anti-inflammatory and antioxidant properties.
AtıfScopus14WoS11OpenAlex10İncele - MakaleAçık Erişim2024Scopus SJRQ1Application of electrocoagulation process for the disposal of COD, NH3-N and turbidity from the intermediate sanitary landfill leachate
Ogedey, Aysenur; Oguz, Ensar
This study aims to determine the COD, NH3-N and turbidity disposal efficiencies from leachate in the Bingöl landfill and highlight the electrocoagulation (EC) process’s performance in removing these pollutants. After establishing that landfill leachate was intermediate aged, its characteristics were identified using physical, chemical and elemental analyses. Six parallel-connected electrode plates with stainless steel as the cathode and aluminium as the anode were used to construct an electrocoagulation cell. After a 40-min treatment interval, the optimal disposal efficiencies for COD and turbidity from the leachate were determined to be 87% and 62%, respectively, at pH 5. Following a 40-min reaction, BOD5 concentration and BOD5/COD ratio were determined to be 85.75 mg O2/L and 0.64, respectively, at pH 5. At a NaCl concentration of 10 mM, the optimum disposal efficiency for NH3-N was determined to be 33%. The reaction kinetics matched pseudo-first-order (PFO) kinetics due to high correlation coefficients (R2 = 0.93–0.99) in removing COD, NH3-N and turbidity under different experimental conditions. The optimal reaction rate constants were determined as 2.93 × 10−2 min−1, 1.92 × 10−2 min−1 and 7.3 × 10−3 min−1 for the disposal of COD, NH3-N and turbidity, respectively. Energy consumption, unit energy consumption and total consumption cost rose in the EC process when the current density was augmented from 15 to 25 mA/cm2.
AtıfScopus14WoS11OpenAlex12İncele - MakaleYalnız künye2024Scopus SJRQ2Uncovering chemical profiles, biological potentials, and protection effect against ECM destruction in H2O2-treated HDF cells of the extracts of Stachys tundjeliensis
Kurt-Celep, Inci; Zheleva-Dimitrova, Dimitrina; Sinan, Kouadio Ibrahime; Uba, Abdullahi Ibrahim; Nilofar; Mahomoodally, Mohamad Fawzi; Aumeeruddy, Muhammad Zakariyyah; Cakilcioglu, Ugur; Dall'Acqua, Stefano; Zengin, Gokhan
The genus Stachys L., one of the largest genera of the Lamiaceae family, is highly represented in Turkey. This study was conducted to determine the bio-pharmaceutical potential and phenolic contents of six different extracts from aerial parts of Stachys tundjeliensis. The obtained results showed that the ethanol extract exhibited the highest antioxidant activity in the antioxidant assays. Meanwhile, the ethanol extract displayed strong inhibitory activity against α-tyrosinase, the dichloromethane extract exhibited potent inhibition against butyrylcholinesterase, and the n-hexane extract against α-amylase. Based on ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry analysis, more than 90 secondary metabolites, including hydroxybenzoic acid, hydroxycinnamic acid, and their glycosides, acylquinic acids, phenylethanoid glycosides, and various flavonoids were identified or tentatively annotated in the studied S. tundjeliensis extracts. It was observed that the application of S. tundjeliensis eliminated H2O2-induced oxidative stress. It was determined that protein levels of phospho-nuclear factor kappa B (NF-κB), receptor for advanced glycation endproducts, and activator protein-1, which are activated in the nucleus, decreased, and the synthesis of matrix metalloproteinase (MMP)-2 and MMP-9 also decreased to basal levels. Overall, these findings suggest that S. tundjeliensis contains diverse bioactive compounds for the development of nutraceuticals or functional foods with potent biological properties.
AtıfScopus12OpenAlex12İncele - MakaleAçık Erişim2024Scopus SJRQ2Cytotoxic, antioxidant, and enzyme inhibitory activities of Centaurea stapfiana extracts and their HPLC-ESI-QTOF-MS profiles: Insights into an unexplored Centaurea species
Zengin, Gokhan; Fernández-Ochoa, Álvaro; de la Luz Cádiz-Gurrea, María; Jiménez, Francisco-Javier Leyva; Uba, Abdullahi Ibrahim; Ak, Gunes; Soomro, Sanam Iram; Balos, Maruf; Cakilcioglu, Ugur; Rodrigues, Maria João
The members of the genus Centaurea have a great interest in pharmaceutical and nutraceutical fields due to their biological potential. Based on this information, we aimed to evaluate the biological properties (antioxidant, enzyme inhibition and cytotoxicity) and chemical profile of the extract of Centaurea stapfiana, an unstudied species. The highest total phenolic content was found in the ethanol/water extract with 32.17 mg GAE/g. A total of 102 of them were identified by HPLC-ESI-QTOF-MS analysis. These compounds were mainly hydroxybenzoic acid and hydroxycinnamic acid as well as flavonoids. In the antioxidant tests, the ethanol/water extract had the best free radical scavenging and reducing ability. However, in the enzyme inhibition test, the ethanol extract was the most active. The extracts were also tested on two tumour cell lines (RAW 264.7 and HepG2) and one non-tumour cell line (S17). The ethanol extract showed the promising effect on HepG2 (cell viability: 28.6 % at 50 g/ml). Furthermore, we examined the interactions between the compounds and enzymatic and cellular targets. A good interaction was found between quercetin-3-xylosyl-(1- > 6)-glucoside and iNOS. In summary, our results suggest that C. stapfiana can be considered as a versatile raw material for the development of health-promoting applications in the pharmaceutical and cosmeceutical fields.
AtıfScopus13OpenAlex14İncele - MakaleAçık Erişim2024Scopus SJRQ2Combining chemical profiles and biological abilities of different extracts from Tanacetum nitens (Boiss. & Noë) Grierson using network pharmacology
Dall'Acqua, Stefano; Yagi, Sakina; Sut, Stefania; Uba, Abdullahi Ibrahim; Ponniya, Sathish Kumar M.; Koyuncu, Ismail; Toprak, Kenan; Balos, Mehmet Maruf; Kaplan, Alevcan; Çakılcıoğlu, Uğur
Tanacetum nitens (Boiss. & Noë) Grierson is an aromatic perennial herb used in Turkish traditional medicine to treat headache, fever, and skin diseases. This study aimed to investigate the chemical composition, antioxidant, enzyme inhibition, and cytotoxic properties of T. nitens aerial parts. Organic solvent extracts were prepared by sequential maceration in hexane, dichloromethane, ethyl acetate, and methanol while aqueous extracts were obtained by maceration or infusion. Nuclear magnetic resonance (NMR) and LC-DAD-MS analysis allowed the identification and quantification of different phytoconstituents including parthenolide, tanacetol B, tatridin B, quinic acid derivatives, β-sitosterol, and glycoside derivatives of quercetin and luteolin. The type and amount of these phytochemicals recovered by each solvent were variable and significant enough to impact the biological activities of the plant. Methanolic and aqueous extracts displayed the highest scavenging and ions-reducing properties while the dichloromethane and ethyl acetate extracts exerted the best total antioxidant activity and metal chelating power. Results of enzyme inhibition activity showed that the hexane, ethyl acetate, and dichloromethane extracts had comparable anti-acetylcholinesterase activity and the latter extract revealed the highest anti-butyrylcholinesterase activity. The best α-amylase and α-glucosidase inhibition activities were obtained from the hexane extract. The dichloromethane and ethyl acetate extracts exhibited the highest cytotoxic effect against the prostate carcinoma DU-145 cells. In conclusion, these findings indicated that T. nitens can be a promising source of biomolecules with potential therapeutic applications.
AtıfScopus7OpenAlex7İncele - MakaleAçık Erişim2024Scopus SJRQ1Exploring Chemical Composition, Antioxidant, Enzyme Inhibitory and Cytotoxic Properties of Glaucium acutidentatum Hausskn. & Bornm. from Turkey Flora: A Novel Source of Bioactive Agents to Design Functional Applications
Yagi, Sakina; Zengin, Gokhan; Uba, Abdullahi Ibrahim; Maciejewska-Turska, Magdalena; Sieniawska, Elwira; Świątek, Łukasz; Rajtar, Barbara; Bahşi, Muammer; Guler, Osman; Dall’Acqua, Stefano
The present study was performed to determine the chemical constituents, cytotoxicity, antioxidant and enzyme inhibition activities of the aerial parts of Glaucium acutidentatum Hausskn. and Bornm. (family Papaveraceae). Methanolic and aqueous extracts were prepared by maceration, homogenizer-assisted extraction (HAE) and infusion. Results showed that the highest total phenolic and flavonoids contents were obtained from the methanol extracts obtained by HAE (53.22 ± 0.10 mg GAE/g) and maceration (30.28 ± 0.51 mg RE/g), respectively. The aporphine, beznyltetrahydroisoquinoline, and protopine types of Glaucium alkaloids have been tentatively identified. Among them, glaucine was identified in all extracts. Flavonoids, phenolic acids, coumarins, organic acids and fatty acids were also detected. Methanolic extract obtained using the HAE method displayed the highest anti-DPPH (41.42 ± 0.62 mg TE/g), total antioxidant (1.20 ± 0.17 mmol TE/g), Cu2+ (113.55 ± 6.44 mg TE/g), and Fe3+ (74.52 ± 4.74 mg TE/g) reducing properties. The aqueous extracts obtained by infusion and HAE methods exerted the best anti-ABTS (103.59 ± 1.49 mg TE/g) and chelating (19.81 ± 0.05 mg EDTAE/g) activities, respectively. Methanolic extract from HAE recorded the highest acetylcholinesterase (2.55 ± 0.10 mg GALAE/g) and α-amylase (0.51 ± 0.02 mmol ACAE/g) inhibition activities, while that obtained by maceration showed the best butyrylcholinesterase (3.76 ± 0.31 mg GALAE/g) inhibition activity. Both extracts revealed the best tyrosinase inhibitory activity (25.15 ± 1.00 and 26.79 ± 2.36 mg KAE/g, p ≥ 0.05). G. acutidentatum maceration-derived aqueous extract showed selective anticancer activity against cells originating from human hypopharyngeal carcinoma. In conclusion, these findings indicated that G. acutidentatum is a promising source of alkaloids and phenolic compounds for variable pharmaceutical formulations.
AtıfScopus13OpenAlex13İncele - MakaleYalnız künye2024Scopus SJRQ1Virtual reality for COPD exacerbation: A randomized controlled trial
Kizmaz, Erhan; Telli Atalay, Orçin; Çetin, Nazlı; Uğurlu, Erhan
Background: Pulmonary rehabilitation (PR) is an effective treatment method for chronic obstructive pulmonary disease (COPD). However, individuals with chronic diseases that require lifelong treatment and experience exacerbations need motivational methods. Objectives: The aim of this study was to examine the effects of virtual reality on symptoms, daily living activity, functional capacity, anxiety and depression levels in COPD exacerbation. Methods: Fifty patients hospitalized for COPD exacerbation were included in the study. They were randomly assigned to two groups. Twenty-five patients participated in a traditional PR (once-daily until discharge), including pedaling exercises. The second/25 patients followed the same protocol but experienced cycling simulation in the forest via virtual reality (VR + PR). All patients were evaluated using 1-minute/Sit-to-Stand test (STST), modified-Medical Research Council (mMRC) scale, COPD Assessment test (CAT), Hospital Anxiety and Depression Scale (HADS), and London Chest Activities of Daily Living (LCADL) before and after the treatment. Results: The STST showed an increase in both groups post-treatment, notably higher in the VR + PR (p = 0.037). Dyspnea levels and CAT scores decreased in all patients, but the decrease was greater in the PR + VR group for both parameters (p = 0.062, p = 0.003; respectively). Both groups experienced a reduction in the HADS scores compared to the pre-treatment, with a more significant decrease in depression and the total score in the VR + PR (p < 0.05). LCADL's sub-parameters and total score, excluding household, decreased in both groups after treatment (p < 0.05). The improvement was more substantial in the VR + PR. Conclusions: Virtual reality provides benefits in the management of COPD exacerbations and can be used safely. Clinical trial registiration: Registered at clinicaltrials.gov, registration ID: NCT05687396, URL: www.clinicaltrials.gov.
AtıfScopus11WoS11OpenAlex15İncele - MakaleAçık Erişim2024Scopus SJRQ2Effects of naringenin on oxidative damage and apoptosis in liver and kidney in rats subjected to chronic mercury chloride
Kahramanoğullari, Merve; Erişir, Mine; Yaman, Mine; Parlak Ak, Tuba
Mercury chloride is a type of heavy metal that causes the formation of free radicals, causing hepatotoxicity, nephrotoxicity and apoptosis. In this study, the effects of naringenin on oxidative stress and apoptosis in the liver and kidney of rats exposed to mercury chloride were investigated. In the study, 41 2-month-old male Wistar-Albino rats were divided into five groups. Accordingly, group 1 was set as control group, group 2 as naringenin-100, group 3 as mercury chloride, group 4 as mercury chloride + naringenin-50, and group 5 as mercury chloride + naringenin-100. For the interventions, 1 mL/kg saline was administered to the control, 0.4 mg/kg/day mercury (II) chloride to the mercury chloride groups by i.p., and 50 and 100 mg/kg/day naringenin prepared in corn oil to the naringenin groups by gavage. All the interventions lasted for 20 days. Mercury chloride administration was initiated 1 h following the administration of naringenin. When mercury chloride and the control group were compared, a significant increase in plasma urea, liver and kidney malondialdehyde (MDA) levels, in kidney superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) activities (p <.001), and a significant decrease in liver and kidney glutathione (GSH) levels (p <.001), in liver catalase (CAT) activity (p <.01) were observed. In addition, histopathological changes and a significant increase in caspase-3 levels were detected (p <.05). When mercury chloride and treatment groups were compared, the administration of naringenin caused a decrease aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH) (p <.01), urea, creatinine levels (p <.001) in plasma, MDA levels in liver and kidney, SOD, GSH-Px, GST activities in kidney (p <.001), and increased GSH levels in liver and kidney. The addition of naringenin-100 increased GSH levels above the control (p <.001). The administration of naringenin was also decreased histopathological changes and caspase-3 levels (p <.05). Accordingly, it was determined that naringenin is protective and therapeutic against mercury chloride-induced oxidative damage and apoptosis in the liver and kidney, and 100 mg/kg naringenin is more effective in preventing histopathological changes and apoptosis.
AtıfScopus13WoS14OpenAlex14İncele - MakaleAçık Erişim2024Scopus SJRQ1Impact of a Novel Valerian Extract on Sleep Quality, Relaxation, and GABA/Serotonin Receptor Activity in a Murine Model
Sahin, Kazim; Gencoglu, Hasan; Korkusuz, Ahmet Kayhan; Orhan, Cemal; Aldatmaz, İsmail Ertuğ; Erten, Fusun; Er, Besir; Morde, Abhijeet; Padigaru, Muralidhara; Kilic, Ertugrul
Insomnia is a major global health issue, highlighting the need for treatments that are both effective and safe. Valerian extract, a traditional remedy for sleep problems, offers potential therapeutic options. This research examined the potential sleep-enhancing effects of VA (Valerian Pdr%2) in mice. The study evaluated sleep quality by comparing the impact of the VA extract against melatonin on brain activity, using electrocorticography (ECoG) to assess changes in brain waves. For this purpose, the study utilized two experimental models on BALB/c mice to explore the effects of caffeine-induced insomnia and pentobarbital-induced sleep. In the first model, 25 mice were assigned to five groups to test the effects of caffeine (caffeine, 7.5 mg/kg i.p) alone, caffeine with melatonin (2 mg/kg), or caffeine with different doses of valerian extract (100 or 300 mg/kg) given orally on brain activity, assessed via electrocorticography (ECoG) and further analyses on the receptor proteins and neurotransmitters. In the second model, a different set of 25 mice were divided into five groups to examine the impact of pentobarbital (42 mg/kg) alone, with melatonin, or with the valerian extract on sleep induction, observing the effects 45 min after administration. The study found that ECoG frequencies were lower in groups treated with melatonin and two doses of valerian extract (100 and 300 mg/kg), with 300 mg/kg showing the most significant effect in reducing frequencies compared to the caffeine control group, indicating enhanced sleep quality (p < 0.05). This was supported by increased levels of serotonin, melatonin, and dopamine and higher levels of certain brain receptors in the melatonin and valerian extract groups (p < 0.05). Modulatory efficacy for the apoptotic markers in the brain was also noted (p < 0.05). Additionally, melatonin and both doses of VA increased sleep duration and reduced sleep onset time compared to the pentobarbital control, which was particularly notable with high doses. In conclusion, the findings suggest that high doses (300 mg/kg) of valerian extract enhance both the quantity and quality of sleep through the GABAergic pathway and effectively increase sleep duration while reducing the time to fall asleep in a pentobarbital-induced sleep model in mice.
AtıfScopus19OpenAlex19İncele - MakaleAçık Erişim2024Scopus SJRQ1The Mediating Effect of Experiential Avoidance on the relationship between psychological resilience and psychological needs in the COVID-19 pandemic
Dursun, Asiye; Kaplan, Yılmaz; Altunbaş, Tuğçe; Bahtiyar, Muhammed
The COVID-19 pandemic that has impinged upon the world affects individuals not only physically but also psychologically. Considering the effects of the pandemic that can be called a challenging life event, the concept of psychological resilience comes to mind. In this study, the effect of multidimensional avoidance on the relationship between psychological resilience and psychological need satisfaction-frustration of adults is discussed through structural equation modeling. The study data were collected online from 506 adults who participated voluntarily from 7 different geographical regions of Turkey. The study findings were obtained by using correlation analysis, structural equation modeling, and path analysis. As a result of the study, it is seen that all the variables of multidimensional avoidance except distraction/suppression and frustration directly affect psychological resilience in satisfaction and frustration of basic psychological needs. In addition, it shows that psychological resilience has a significant effect on satisfaction and frustration of basic psychological needs, both directly and indirectly through multidimensional avoidance.
AtıfScopus13WoS15OpenAlex13İncele - MakaleYalnız künye2024Scopus SJRQ2Combating with COPD by QiGong Physical and Mental Exercise
Kaplan Serin, Emine
Physical activity levels of patients with chronic obstructive pulmonary disease (COPD) are low due to the symptoms of COPD. The patients diagnosed with COPD are headed for complementary and alternative treatments to reduce the COPD symptoms, facilitate the treatment, and increase their physical activity. One of these treatments is QiGong, which is not yet common in our country. QiGong is a type of exercise based on ancient Chinese medicine, and mainly consists of active and passive exercises. These exercises open energy channels in the body, and thus prevent and/or heal diseases by establishing energy balance in the body through meditation, breath control, and bodily exercises. According to a literature review abroad, there are a small number of scientific studies related the therapeutic effect of QiGong exercises on symptom control, anxiety, reduction of stress and depression, increase in physical activity and quality of life, and the development of lung function of patients with COPD. By considering the educative role of nurses, it is important that the nurse has adequate knowledge of the treatment and care of patients with COPD. Therefore, this review is compiled to be informative about the effects of QiGong in the treatment of COPD, and assistance to subsequent studies.
AtıfScopus4WoS4İncele - MakaleAçık Erişim2024Scopus SJRQ1Determination of oxidative stress responses caused by aluminum oxide (γ-Al2O3 and α-Al2O3) nanoparticles in Gammarus pulex
Serdar, Osman; Aydin, Ayşe Nur; Çimen, Isıl Canan Çiçek
The rapid growth in the use of aluminum oxide nanoparticles (Al2O3 NPs) in various fields such as medicine, pharmacy, cosmetics industries and engineering, and the fact that these NPs and their wastes mix with the aquatic environment and damage the aquatic ecosystem, affect the organisms in the water, enter the food chain and reach humans is a major problem is cause for concern. The aim of this study is to investigate the oxidative stress caused by two separate forms of aluminum oxide, γ-Al2O3 and α-Al2O3, in Gammarus pulex, which is a good indicator species, with biochemical parameters. For this purpose, G. pulex was exposed to different concentrations (0, 10, 20, 40 ppm) of γ-Al2O3 and α-Al2O3 separately. The experiments were carried out for 24 and 96 h by creating 3 repeated experimental groups consisting of 4 groups. For biomarker analysis, superoxide dismutase (SOD), catalase (CAT) activities and glutathione (GSH) and thiobarbituric acid (TBARS) levels were performed using an ELISA kit. As a result of the in experimental study, it was observed that both nanoparticles affected oxidative stress and antioxidant parameters after 96 h compared to the control group. Increases in SOD activity were observed, γ-Al2O3 caused a decrease in CAT activity at 24 h, and α- Al2O3 caused increases in CAT activity at 96 h. Decreases in GSH levels and increases in TBARS levels have been observed.
AtıfScopus14OpenAlex14İncele - MakaleAçık Erişim2024Scopus SJRQ1Assessment of toxicity and oxidative stress induced by rare earth oxide nanoparticles in brine shrimp (Artemia salina)
Unal, Ilkay; Erturk Gurkan, Selin; Aydogdu, Burcu
This study meticulously explored the oxidative stress effects induced by lanthanum (III) oxide (La2O3), erbium (III) oxide (Er2O3), and yttrium (III) oxide (Y2O3) nanoparticles on Artemia salina, with the objective of evaluating the environmental toxicity of rare earth oxide nanoparticles. The characterization of the nanoparticles was conducted using a suite of advanced techniques, including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), dynamic light scattering (DLS), and zeta potential analysis. Artemia salina, a widely recognized model organism in ecotoxicological research, was exposed to these nanoparticles under meticulously controlled laboratory conditions. The investigation focused on quantifying oxidative stress markers, such as reduced glutathione (GSH), malondialdehyde (MDA), and antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD), and glutathione-S-transferase (GST). The findings revealed significant alterations in these biomarkers, indicating nanoparticle-induced oxidative stress, which varied according to the type of nanoparticle and the duration of exposure.
AtıfScopus9OpenAlex9İncele - MakaleAçık Erişim2024Scopus SJRQ1Evaluation of antioxidant, antimicrobial, and bioactive properties and peptide sequence composition of Malatya apricot kernels
Aydın, Çağlar Mert; Çelikbıçak, Ömür; Hayaloğlu, Ali Adnan
BACKGROUND: This study used four different apricot (Prunus armeniaca) kernels cultivated in Malatya during two consecutive years. The varieties were Hacihaliloglu, Hasanbey, Kabaasi, and Zerdali. The physicochemical properties of the kernels were determined, and the bioactive content of the kernels was evaluated using kernel hydrolysates prepared using trypsin. RESULTS: With regard to the physicochemical properties of the kernels, the dry matter ratio and protein content were the highest in the Hacihaliloglu variety; the ash ratio was the highest in the Kabaasi variety, and the free oil ratio was the highest in the Hasanbey variety. The bioactive compound content changed according to kernel variety. Angiotensin-converting enzyme inhibitors activity was found to be the highest in the Hacihaliloglu and Hasanbey varieties, which had the lowest amygdalin content, and Zerdali had the highest amygdalin content. The antioxidant and antimicrobial effects of the kernels varied, with Hasanbey and Kabaasi generally having the highest content in both analyses. Moreover, a concentration of 20 mg mL−1 of the hydrolysate was determined to have a destructive effect for the microorganisms used in this study. The storage protein of the kernels, except Hacihaliloglu, was found to be Prunin 1, with the longest matching protein chain in the kernels being R.QQQGGQLMANGLEETFCSLRLK.E. CONCLUSION: The results suggest that the peptide sequences identified in the kernels could have antihypertensive, antioxidative, and Dipeptidyl peptidase IV (DPP-IV) inhibitory effects. Consequently, apricot kernels show potential for use in the production of functional food products. Of the kernels evaluated in this study, Hacihaliloglu and Hasanbey were deemed the most suitable varieties due to their higher bioactive content and lower amygdalin content.
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