Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Akkurt, Nevzat(31)
- Gul, Muhammet(11)
- Yucesan, Melih(11)
- Paksoy, Mehmet Yavuz(7)
- Serdar, Osman(7)
- Tanyol, Mehtap(7)
- Torğut, Gülben(7)
- Utku, Anıl(7)
- Xu, Qian(7)
- Aksu, Önder(6)
- Alataş, Mevlüt(6)
- Kocabaş, Mehmet(6)
- Xiong, Yaxuan(6)
- ALMisned, Ghada(5)
- Akmaz, Düzgün(5)
- Alp Dal, Nursel(5)
- Aslan, Naim(5)
- Dal, Nursel Alp(5)
- Du, Yanping(5)
- Eldin, Sayed M.(5)
- Guler, Omer(5)
- Ince, Muharrem(5)
- Qiang, Yujie(5)
- Say, Yakup(5)
- Tekin, H.O.(5)
- Topal, Murat(5)
- Yildirim, Numan(5)
- Yilmaz, Ersen(5)
- Zengin, Gokhan(5)
- Zhang, Hui(5)
- Aksakal, B.(4)
- Basgoz, Oykum(4)
- Can, Umit(4)
- Etli, Serkan(4)
- Ezer, Tülay(4)
- Güler, Ömer(4)
- Pekdemir, Mustafa Ersin(4)
- Pıhtılı, Güzin(4)
- Susam, Selim Orhun(4)
- Tasar, Neslihan(4)
Yayınlar
- MakaleAçık Erişim2022Scopus SJRQ1A method for generation of substitution box based on random selection
Artuğer, Fırat; Özkaynak, Fatih
Two basic requirements must be met to encrypt data. These requirements are confusion and diffusion properties. In particular, block cipher algorithms are based on a cryptographic component known as substitution-box to provide the need for confusion. Therefore, attack scenarios generally focus on this cryptographic component. There are alternative design approaches for substitution-box design. It is known that each design approach has several advantages and disadvantages. In this study, an alternative method is proposed to address the problems of the substitution-box design approach based on random selection. The success of the proposed method has been tested in three different scenarios. Analysis results for these three scenarios showed that generated substitution-box provides performance increase for nonlinearity criterion from s-box design criteria. Successful results achieved; It points out that improvement cryptographic components can be used in a variety of practical applications such as block ciphers, masks to prevent side-channel attacks, random number generators, and image encryption algorithms.
AtıfScopus29WoS25OpenAlex35
İncele - MakaleAçık Erişim2022Job Satisfaction, Intent to Stay at Work, and Burnout Levels of Nurses Working in Coronavirus Disease 2019 Clinics: A Cross-Sectional Study
Erkuş Küçükkelepçe, Gülhan; Arslan Şeker, Sevda; Karaca, Türkan
Objective: It is thought that the fact that coronavirus disease 2019 pandemic process has been continuing for a long time, and the level of job satisfaction of nurses may have an impact on their intention to experience burnout and stay at work. This study aimed to determine the relationship between job satisfaction, intention to stay, and burnout levels of nurses working in coronavirus disease 2019 clinics. Methods: This descriptive and correlational study was conducted with 325 nurses who were working in coronavirus disease 2019 clinics. Data were collected using the sociodemographic characteristics form, the Minnesota Satisfaction Questionnaire, the Maslach Burnout Inventory, and the Intent to Leave Job Scale. Descriptive statistics, correlation analysis, and regression analysis were used in the analysis of the research data. Results: Emotional exhaustion, depersonalization, personal achievement, and intent to leave explain 45% of job satisfaction (F = 67.911, p =.000); job satisfaction and intent to leave explain 40% of emotional exhaustion (F = 111.470, p =.000), 16% of depersonalization (F = 33.785, p =.000), and 20% of personal achievement (F = 43.102, p =.000); job satisfaction, emotional exhaustion, depersonalization, and personal achievement explain 24% of intent to leave (F = 27.190, p =.000). Conclusion: The prolongation of the coronavirus disease 2019 pandemic, the uncertainty of the process, and the conditions related to the working environment of the nurses have an effect on job satisfaction, burnout, and intent to leave. The continuity of the well-being of employees is an important issue that needs to be emphasized and evaluated, as it will have a multi-faceted effect to be ready for different pandemics in the near/far future.
AtıfScopus1WoS1
İncele - MakaleAçık Erişim2022Scopus SJRQ1Academicians’ awareness, attitude, and use of open access during the COVID-19 pandemic
Turgut, Yigit Emrah; Aslan, Alper; Denizalp, Nuran Varlı
The aim of this research is to reveal academics’ awareness, attitude, and use of open access. In line with the research purpose, the survey research design is adopted. This research consists 151 academics from 12 basic research areas; eight of them being Professor Dr, 17 being Associate Professor Dr, 49 being Doctor Lecturer, and 77 being Research Assistant or Lecturer. A questionnaire consisting of 19 open access and five demographic information questions was used for the data collection tool. The research results show that 75% of the academics have open access awareness and that their awareness is generally created by information that they obtain through the Internet and their friends. In addition, most of the academics indicate that their awareness of open access has increased during the pandemic period. When considering the level of academics’ use of open access, it is found that 75% of the academics use articles in open access journals for their own research and 51% of the academics do not publish any articles in open access journals.
AtıfScopus20WoS18OpenAlex19
İncele - MakaleAçık Erişim2022Scopus SJRQ4New dinuclear cyanido complexes with amine alcohol ligand: Synthesis, characterization and biotechnological application potential
Korkmaz, N.; Korkmaz, Ş.A.; Ceylan, Y.; İmamoğlu, R.; Bülbül, A.S.; Karadağ, A.
In this study, the cyanido complexes given by the formula [Ni(Abut)Ni(CN)4 ]·8H2 O (C1), [Cu(Abut)2 Ni(CN)4 ]·7H2 O (C2), [Zn(Abut)Ni(CN)4 ]·8H2 O (C3) and [Cd(Abut)Ni(CN)4 ]·7H2 O (C4) were ob-tained by microwave synthesis method. The powder forms of the complexes were characterized by elemental, FT-IR spectroscopy, and thermal analysis. And also antibacterial, antibiofilm and anticancer activities were investigated. The splitting stretching bands of cyanido groups in the FT-IR spectra of C1-C4 indicated the assets of terminal and end cyanido groups. The antibacterial activities of C1-C4 were tested with nine Gram negative and six Gram positive bacteria. The most efficient antibacterial activity of complexes was observed at 1000 µg/ml-1 concentration. Anticancer activity was tested using HeLa cell line and MTT test. The studied cyanide complexes have been shown to decrease the viability of HeLa cells with IC50 values 14.86, 6.5, 7.2 and 19.2 µg/ml for C1, C2, C3 and C4 complex, respectively.
- MakaleYalnız künye2022Scopus SJRQ2Integrated electron beam irradiation treatment with hydrogen peroxide aqueous solution to inactivate Salmonella on grape tomatoes
Omac, Basri; Moreira, Rosana G.; Castell-Perez, Elena M.
This study investigated the efficacy of integrated electron beam (e-beam) irradiation and hydrogen peroxide (H2O2) aqueous solution treatments to inactivate mixed strains of Salmonella inoculated in grape tomatoes. Whole grape tomatoes were inoculated with a mixed bacterial cocktail composed of five strains of Salmonella enterica corresponding to serotypes Rissen (SAL1449), Montevideo (SAL4599), Saintpaul (476398), and Typhimurium (ATCC 13311 and ATCC 700720), dried in a biological safety cabinet for 2 h at room temperature and then stored at 4°C for 24 h to facilitate bacterial attachment before treatment. Tomatoes in H2O2 (60 mg/L) aqueous solution were irradiated at 0.45, 0.60, 0.75, 1.0, and 1.25 kGy dose. The combined treatment of 1.0 kGy radiation dose and 60 mg/L H2O2 achieved 4-log reductions in Salmonella. The D10−average value of Salmonella in the present study was 0.25 ± 0.01 kGy. Regarding the effect of the treatment on tomato quality, the combined application of e-beam up to 1.25 kGy and H2O2 (60 mg/L) did not affect (p >.05) the color and texture of grape tomatoes compared to non-irradiated samples. Furthermore, the combined treatments of e-beam and H2O2 aqueous solution reduced the dose uniformity ratio (DUR) by 7%, a relevant finding regarding commercial applications of electron beam accelerators. Exposure of the tomatoes to e-beam and water wash with added H2O2 is a promising decontamination system for use in tomatoes and other produce processing. Further studies on the optimization of this integrated treatment are needed. Practical Applications: Electron beam irradiation of tomatoes immersed in hydrogen peroxide (H2O2) solution reduces the dose required to eliminate pathogens in the fresh produce. The integrated treatment ensures minimal changes to produce quality and increased treatment efficiency in terms of dose uniformity.
AtıfScopus5WoS5OpenAlex4İncele - MakaleAçık Erişim2022Scopus SJRQ3Investigation of rutting, fatigue and cracking resistance parameters of CR modified warm asphalt binders compare with SBS modified binders
Akpolat, Mustafa
This study compares the rutting and cracking resistance and fatigue parameters of crumb rubber (CR) modified warm asphalt binders, which were determined by viscoelastic continuum damage (VECD) theory. The effect of the combination of CR modification and Sasobit, a warm mix additive, was investigated. Performance of CR + Sasobit compound was compared with styrene-butadiene-styrene (SBS) modification. Newly developed rheological tests such as multi stress creep recovery (MSCR), lineer amplitude sweep (LAS) and conventional tests were applied to modified binders. It was determined that the CR + Sasobit modified binders improved the rutting parameter better in comparison to SBS-added binders. Although the CR additive improved the rheological properties of the binder at low and medium temperatures, this effect was reduced when used with Sasobit additive. Sasobit additive increased the stiffness and decreased the fatigue parameter at low temperatures. Besides, the results of the LAS test revealed that at high strain values (i.e.> 6%), the fatigue life of CR and Sasobit modified binders was lower than the fatigue life of the pure binder. In other words, CR and Sasobit modified binders could not preserve material integrity.
AtıfScopus13WoS13OpenAlex12İncele - MakaleAçık Erişim2022Scopus SJRQ1A Bayesian BWM and VIKOR-based model for assessing hospital preparedness in the face of disasters
Saner, Halit Serdar; Yucesan, Melih; Gul, Muhammet
Hospitals are the first point of contact for people in the face of disasters that interfere with the daily functioning of life and endanger health and social life. All preparations should be made considering the worst possible conditions and the provided service should continue without interruption. In this study, a multi-criteria decision-making model was developed to evaluate disaster preparedness of hospitals. This decision model includes Bayesian best–worst method (BBWM), the VlseKriterijumska Optimizacija I Kompromisno Resenje (VIKOR) and technique for order preference by similarity to ideal solution (TOPSIS) methods. With the proposed decision model, six main criteria and 34 sub-criteria related to disaster preparedness of hospitals were considered. The criteria and sub-criteria evaluated in pairwise comparison manner by the experts were weighted with BBWM. These weight values and the data obtained from the six Turkish hospitals were combined to provide inputs for VIKOR and TOPSIS. In addition, a comparative study and sensitivity analysis were carried out using weight vectors obtained by different tools. BBWM application results show that the “Personnel” criterion was determined as the most important criterion with an importance value of 26%. This criterion is followed by “Equipment” with 25%, “Transportation” with 14%, “Hospital building” and “Communication” with 12%, and “Flexibility” with 11%. Hospital-2 was determined as the most prepared hospital for disasters as a result of VIKOR application. The VIKOR Q value of this hospital was obtained as 0.000. According to the results of the comparative study, Hospital-2 was determined as the most disaster-ready hospital in all six different scenarios. This hospital is followed by Hospital-4 (Q = 0.5661) and Hospital-5 (Q = 0.7464). The remaining rankings were Hospital-6, Hospital-3 and Hospital-1. The solidity of the results was checked with TOPSIS. Based on TOPSIS application results, Hospital-2 was again found the most-ready hospital. The usage of BBWM in this study enabled the expert group’s views to be combined without loss of information and to determine the criteria and sub-criteria weights with less pairwise comparisons in a probabilistic perspective. Via the “Credal ranking”, which is the contribution of BBWM to the literature, the interpretation of the hierarchy between each criterion has been performed more precisely.
AtıfScopus48WoS37OpenAlex51İncele - MakaleYalnız künye2022Scopus SJRQ2Interval basic uncertain information and related aggregations in decision making
Jin, Lesheng; Mesiar, Radko; Yager, Ronald; Kaya, Sema Kayapinar
The recently proposed basic uncertain information can directly present numerical uncertainties for given real values, but it cannot handle given interval values which themselves also have uncertainties. Against this background, this work proposes the concept of interval basic uncertain information which serves as a generalization of basic uncertain information and involves two types of uncertainties. We analyze some basic operations, weighted arithmetic mean and preference transformation for interval basic uncertain information. The Rule-based decisions and the comprehensive certainty of interval basic uncertain information are also discussed. An illustrative example of multi-source multi-criteria evaluation under interval basic uncertain information environment is presented.
AtıfScopus18OpenAlex17İncele - MakaleYalnız künye2022Scopus SJRQ2Structural characterization and oxidative stability of black cumin oil oleogels prepared with natural waxes
Orhan, Necla Ozdemir; Eroglu, Zeynep
In this study, black cumin oil (BCO) oleogel was produced using natural waxes (beeswax: BW, sunflower wax: SFW, and carnauba wax: CW) to offer a healthy alternative to shortening. Oiling-off was observed only in the BW oleogel (3.88 ± 0.02%). The CW oleogel had the lowest Ea (354.82 kJ/mol), indicating greater resistance to thermal degradation. The highest G′ and G″ were observed in the CW oleogel, while the lowest was observed in the BW oleogel. All oleogel samples displayed weak gel properties (tan δ > 0.1), but the lowest tan δ value belonged to the CW oleogel (0.12). After 4 weeks of storage, the peroxide values of the oleogels were lower than those of bulk oil (p <.05). Finally, the oxidation results showed that the BCO structuring by the waxes effectively protected it from oxidation over eight weeks of storage. Novelty impact statement: The most important innovation of the present study was to investigate the effect of BCO oleogelation on the stability of thymoquinone, the main phenolic compound of BCO. The BCO oleogels had higher thymoquinone content during the first half of the storage period compared with bulk BCO, showing that the oleogel network provides a protective effect against oxidation and thermal degradation.
AtıfScopus14WoS11OpenAlex17İncele - MakaleAçık Erişim2022Scopus SJRQ2Chrysin and flunixin meglumine mitigate overloaded copper-induced testicular and spermatological damages via modulation of oxidative stress and apoptosis in rats
Parlak Ak, Tuba; Tatli Seven, Pinar; Gur, Seyfettin; Gul, Burcu; Yaman, Mine; Seven, Ismail
This study aimed to evaluate the possible protective actions of chrysin and flunixine meglumine on testicular and spermatological injuries experimentally stimulated by copper. We separated 36 male Sprague–Dawley rats into six equal groups: control, chrysin, flunixine meglumine, copper, copper +chrysin and copper +flunixine meglumine. Chrysin (50 mg/kg/bw/po), flunixine meglumine (2.2 mg/kg/bw/ip) and copper (500 mg/kg/bw/po) were administered day to day for 21 days. Copper administration caused significant morphological, physiological and biochemical alterations compared to the control group, which are as follows: production of oxidative stress, thanks to rise in testis lipid peroxidation and fall in antioxidant enzyme concentrations, decrease in sperm quality and increase in morphologic sperm abnormalities, suppression of spermatogenesis and prominent alterations in the testis histomorphology and induction of apoptosis in the testis tissues. On the other hand, compared to the copper group, treatment with chrysin or flunixine meglumine significantly attenuated these alterations. In conclusion, chrysin and flunixine meglumine have benefits such as antioxidant, antiapoptotic and anti-inflammatory against copper-induced testicular and spermatological damages in rats via the modulation of oxidative stress and apoptosis. Consequently, chrysin is a natural product which has comparable therapeutic actions to flunixine meglumine on the male reproductive system.
AtıfScopus4OpenAlex4İncele - MakaleYalnız künye2022Scopus SJRQ2Thermal analysis of a radiative nanofluid over a stretching/shrinking cylinder with viscous dissipation
Alqahtani, Aisha M.; Riaz Khan, M.; Akkurt, Nevzat; Puneeth, V.; Alhowaity, Awatif; Hamam, Haneen
This study explores the impact of thermal radiation and viscous dissipation on the stagnation point flow of a copper–water nanofluid across a convective stretching/shrinking cylinder. The copper suspension in the base fluid water enables the fluid to conduct more heat by increasing its thermal conductivity. The mathematical model that governs the flow of Cu-H2O nanofluid is formulated by the system of partial differential equations (PDEs) which are then subjected to transformation by introducing suitable similarity variables so the system is transformed to the Ordinary Differential Equations (ODEs). These equations have been solved numerically via the bvp4c package in MATLAB. The outcomes have been signified graphically in the form of heat transfer rate, temperature, skin friction and velocity which are dependent on the concerning flow parameters. For each of these result, dual solutions have been produced which are conditional on the shrinking of cylinder. These results declare that the skin friction increases for the shrinking cylinder and decreases for the stretching cylinder whereas an opposite trend is seen for the rate of heat transfer. Similarly, heat transfer is found to be decreasing for the increase in both Biot and Eckert number. Meanwhile, the existence of greater values of curvature parameter causes to enhance both first and second solution of velocity as well as the temperature is augmenting with the increase in Eckert number and volume fraction of nano particles.
AtıfScopus38OpenAlex39İncele - MakaleYayıncıda açık erişim2022Scopus SJRQ4Epiphytic bryophyte vegetation of Fagus orientalis trees in Hıdırnebi Plateau (Trabzon, Turkey); [Эпифитная бриофитная растительность на стволах деревьев Fagus orientalis на плато Хыдырнеби (Трабзон, Турция)]
Alataş, Mevlüt; Ezer, Tülay; Erata, Hüseyin; Batan, Nevzat
In this study, the epiphytic bryophyte vegetation of Fagus orientalis forests in Hıdırnebi Plateau (Trabzon, Turkey) was investigated. A total of 34 relevés taken from living tree trunks in the different vegetation periods of 2020 were analysed according to the Braun-Blanquet methodology. As a result of the analyses, the Leskeello nervosae–Pterigynandretum filiformis, Leskeello nervosae–Pterigynandretum filiformis lewinskyetosum rupestris subass. nov., Pseudoleskeello nervosae–Raduletum lindbergianae ass. nov. and Pseudoleskeello nervosae–Raduletum lindbergianae isothecietosum alopecuroidis subass. nov. were described and characterised as a new epiphytic syntaxa. The Leskeello nervosae–Pterigynandretum filiformis is also new to Turkey. In addition, the ecological and floristical characteristics of the syntaxa were evaluated.
AtıfScopus3OpenAlex2İncele - MakaleAçık Erişim2022Scopus SJRQ3Economic analysis of rare earth element processing methods for Mountain Pass ore
Uysal, T.
The increasing demand for rare earth elements (REE) in highly strategic sectors such as hybrid electric vehicles, renewable energy, communication technologies, and the defense industry has made REE production methods important. In recent years, studies on REE have increased rapidly; however there are many studies on REE, there are not enough studies in the literature on the economics of the beneficiation process. RE ores are generally leached after beneficiation by gravity, magnetic and flotation methods. In this study, direct leaching, attrition scrubbing and leaching, and flotation and leaching methods are evaluated economically based on the data for the Mountain Pass (MP) facility. According to the sensitivity analysis performed as a function of capital cost (CAPEX), operating cost (OPEX), and rare earths oxides (REO) recovery, REO recovery has the biggest effect on the process economies. Although the flotation method entails additional investment and operating costs, transportation and operating costs are significantly reduced result of the higher grade and recovery. The flotation method is more profitable, with larger NPV and IRR values and a shorter payback period.
AtıfScopus8WoS8OpenAlex10İncele - MakaleAçık Erişim2022Scopus SJRQ2Effects of silver/selenium/chitosan doped hydroxyapatite coatings on REX-734 alloy: Morphology, antibacterial activity, and cell viability
Aksakal, B.; Say, Y.; Sinirlioglu, Z.A.
The goal of this study was to improve the antibacterial activity and cell viability of the Rex-734 alloy in biomedical applications. Various biocomposite coatings, such as single-layer hydroxyapatite (HAp), HAp/silver(Ag), and HAp/selenium(Se)/chitosan(Chit), were applied to Rex-734 alloy at various film thicknesses. The surface coatings were characterized by scanning electron microscopy, SEM, EDX, XRD and coating thickness and hardness of surface coatings were measured. The in vitro antibacterial activities of the coated and uncoated substrates were tested against Esherichia coli JM 103 and Staphylococcus aureus ATCC29293. In vitro cell–material interactions using Saos-2 osteoblast cells were characterized by the 3-(4,5-dimethylthiazol2-yl)− 2,5-diphenyltetrazolium bromide (MTT) assay for cell viability. The post-coating sintering parameters were shown to have a significant effect on the surface morphology. When compared to single HAp and HAp/Ag coatings, Se and Chit additions to HAp powders revealed good crack-free coating surfaces. Crack-free coating morphologies were achieved with a sintering speed of 3 °C/min. While single-HA coatings had an antimicrobial efficiency of 83% against E. coli, this value increased to 94% with Ag additive and to 85% with Se additive. Similarly, Ag and Se additives improved HAp's antimicrobial efficiency against Staphylococcus aureus. Cell viability decreased in the HAp/Ag coating at 86.5% and 90.93%, but increased significantly (p < 0.05) in the HA/Se-Chit coating at 137,43% and 158.23% at the end of the first and seventh days of incubation, respectively. The addition of Ag/Se/Chit to HAp increased the viability of the Rex-734 cells. Furthermore, it was revealed that the HAp-doped Se/Chit duplex biocomposite coating groups increased bone cell viability at much higher rates than the single-layer HAp coatings.
AtıfScopus12WoS8OpenAlex8İncele - MakaleAçık Erişim2022Scopus SJRQ1A multicriteria approach to integrating occupational safety & health performance and industry systems productivity in the context of aging workforce: A case study
Ortiz-Barrios, Miguel; Silvera-Natera, Esnela; Petrillo, Antonella; Gul, Muhammet; Yucesan, Melih
Aging represents one of the greatest challenges that mankind will have to face in the 21st century. In this regard, there is a need to deepen the technical and organizational aspects for rebalancing the job/employee relationship. Nevertheless, there are no robust approaches assisting decision-makers in the effective management of Occupational Safety & Health Performance (OSHP) and Industry Systems Productivity (ISP) convergence with a focus on Aging Workforce (AW). There is no single and unique solution. Therefore, in a win-to-win logic that favors the characteristic of the reference scenario, the aim of this paper is to propose a multicriteria approach to integrate OSHP and ISP in the context of AW. More specifically, Intuitionistic Fuzzy Analytic Hieararchy Process (IF-AHP) was used to elicit the criteria and sub-criteria under uncertainty considering degree of belongingness and non-belongingness. Decision Making Trial and Evaluation Laboratory (DEMATEL) was applied to evaluate the presence and strength of the interrelations and feedback among OSHP and ISP criteria and sub-criteria. Finally, Combined Compromise Solution (CoCoSo) was implemented to calculate a Working Suitability Index (WSI) per aging. Based on this index, interventions on each worker are proposed to underpin redesign of the company while to provide a flexible management propelling high performance in terms of OSHP and ISP. A real case study in Colombia is presented. The results revealed that Efficiency and Quality with 0.162 were found to be the most important factors in evaluating the performance of aging electrical engineers while Psychosocial risk and Occupational Safety were concluded to be the main drivers for a joint OSHP-ISP aging workforce management. The model can be an useful tool for policy and business decision-makers from the electrical sector and can be replicated with slight changes in other industries.
AtıfScopus17WoS11OpenAlex23İncele - MakaleAçık Erişim2022Scopus SJRQ3Electrochemical Detection of Ivermectin Used for the Treatment of COVID-19 with Glutardialdehyde-Modified Glassy Carbon Electrode
Koçak, Berna; İpek, Yeliz
In this study, the surface of the glassy carbon electrode was modified with glutardialdehyde. The modified glassy carbon electrode showed electrocatalytic activity against ivermectin. The glassy carbon electrode modified with glutardialdehyde showed high sensitivity, selectivity, and stability in the determination of ivermectin. The peak current of glutardialdehyde oxidation obtained by differential pulse voltammetry decreased inversely with the ivermectin concentration. Ivermectin inhibited the oxidation reaction of glutardialdehyde and caused a decrease in current. This change made the analysis of ivermectin electrochemically possible. In order to demonstrate the applicability of the developed method in real samples, recovery studies were carried out in tap water and urine. The highest sensitivity (0.45 µA/((µmol·L−1)(cm2))) was achieved with urine sample and the lowest detection limit as 2.66 × 10−6 mol·L−1 was obtained with BRT solution sample. Graphical abstract: [Figure not available: see fulltext.]
AtıfScopus14WoS13OpenAlex13İncele - MakaleYalnız künye2022Scopus SJRQ2Comparative Content, Biological and Anticancer Activities of Heracleum humile Extracts Obtained by Ultrasound-Assisted Extraction Method
Ocal, Mustafa; Altunoglu, Yasemin Celik; Angeloni, Simone; Mustafa, Ahmed M.; Caprioli, Giovanni; Zengin, Gokhan; Paksoy, Mehmet Yavuz; Baloglu, Mehmet Cengiz
As the safety and effectiveness of synthetic drugs remain in doubt, researchers are trying to develop natural medicines from medicinal plants. Herein, ethyl acetate, methanol and water extracts from the Heracleum humile plant were obtained by an ultrasonic-assisted extraction process and the aim was to evaluate some biological effects of the extracts due to the limited data on the pharmacological properties of Heracleum humile in the literature. Weak antibacterial activity was observed on tested bacterial species. The minimum inhibitory concentration and the minimum bactericidal concentration values ranged from 250 to 500 μg/mL. In addition, cytotoxic activity was determined using the MTT test. The strongest findings were determined for ethyl acetate extract on the MDA-MB-231 cell lines at the 48th hour (IC50:97.94 μg/mL), followed by the MCF-7 cell lines at the 24th hour (IC50:103.9 μg/mL). All extracts of Heracleum humile contained mainly flavonoids, phenolic acids and their derivatives, i. e., well-known compounds that possess numerous biological activities such as antioxidant, anti-inflammatory, anticancer, antimicrobial etc. The study results could provide important information that Heracleum humile could be a potential candidate as a natural enzyme inhibitor. It can be concluded that these extracts could be useful in the elementary step of improving novel plant-derived multifunctional pharmaceuticals.
AtıfScopus6OpenAlex11İncele - MakaleAçık Erişim2022Scopus SJRQ3Antioxidant, Antityrosinase Activities and Composition of Essential Oils Obtained from Roots and Fruits of Ferulago longistylis Boiss.
Kürkçüoğlu, Mine; Ağalar, Hale Gamze; Temiz, Burak; Duran, Ahmet; Paksoy, Mehmet Yavuz; Başer, Kemal Hüsnü Can
This study was aimed to evaluate the potential uses of Ferulago longistylis Boiss. essential oils in cosmetic applications. The air dried roots and fruits were subjected to water distillation by using a Clevenger apparatus for 3 h. Both essential oils were analyzed by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC/MS) systems, simultaneously. The essential oil yields of the fruits and roots were calculated as 4% and 0.91%, respectively. The major compounds were identified as 2,3,6-trimethylbenzaldehyde (29.5%), cis-chrysanthenyl acetate (15.2%), (Z)-β-ocimene (12.4%), α-pinene (12.0%) and myrcene (11.4%) in the fruit essential oil while the root essential oil was characterized with high content of α-pinene (90.5%). Both essential oils were evaluated for their potential antioxidant and antityrosinase activities. The both essential oils showed weak Trolox equivalent antioxidant capacity and DPPH radical scavenging activity. The fruit essential oil showed weak antityrosinase (%25 inhibition, 1 mg/mL) activity while the root essential oil was inactive. The results concluded that both essential oils were not promising in cosmetic applications.
AtıfScopus3OpenAlex1TR Dizin1İncele - MakaleAçık Erişim2022Scopus SJRQ2The Bioremediation Capacity of Sphingomonas melonis for Methomyl-Contaminated Soil Media: RSM Optimization and Biochemical Assessment by Dreissena polymorpha
Önder Erguven, Gokhan; Serdar, Osman; Tanyol, Mehtap; Cikcikoglu Yildirim, Nuran; Yildirim, Numan; Durmus, Barbaros
The bioremediation capacity of S. melonis for methomyl investigated with RSM. Oxidative stress and neurotoxic response determined in D. polymorpha. COD and TOC levels were measured. GSH, MDA levels and CAT, SOD, AChE activities in D. polymorpha exposed to before (group A) and after (group B) bioremediated media during 24 and 96 h were tested by using ELISA kit. AchE activity was decreased 24th h but increased during 96th h in group B compared with group A (p<0.05). MDA levels and CAT activities were decreased during 24 h and 96 h in group B compared with group A (p<0.05). GSH levels were increased during 24 h and 96 h in group B compared with group A (p<0.05). SOD activity did not show a significant change in group B (p<0.05). Methomyl could be effectively remediated by S. melonis and CAT, AChE activities and GSH, TBARS levels of D. polymorpha are useful biomarkers for evaluating the bioremediation capacity.
AtıfScopus5WoS6OpenAlex6İncele - MakaleYalnız künye2022Scopus SJRQ3Boron-incorporated biocomposite coatings on 316L and NiTi alloys: Enhanced structural, antibacterial activity, and cell viability performances
Aslan, N.; Aksakal, B.; Aksoy, M.E.
Boron doped (5 %, 10%, and 15 wt.%) Hydroxyapatite (B-HA) biocomposites were syntesized and coated on 316L SS and NiTi (Ni-45Ti) metallic substrates by using the electrophoretic deposition process (EPD). The morphological and structural characterization of the coatings was executed using scanning electron microscopy (SEM) and X-ray diffraction devices (XRD). Antibacterial tests were conducted using Escherichia coli (E. coli, JM103) and Staphylococcus aureus (S. aureus, ATCC29293) microorganisms. The mitochondrial activity assay (MTT)-[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] was used to examine cell viability and cytotoxicity in Saos-2 osteoblast cells. HA and boron peaks, as well as B-TCP and metallic components, were detected in XRD examinations. Porous morphologies were generated on the surface with boron doped B-HA coatings, as revealed by SEM views. Antibacterial activity studies revealed that both metallic coating groups, notably with boron doping, demonstrated antibacterial activity against gram-negative E. coli and gram-positive S. aureus. The antibacterial activity of the 316L group was shown to be better than that of the NiTi group in comparisonal testing. The syntesized boron-doped biocomposite coatings did not have any detrimental effects on living cells, according to cell viability studies. The cell viability rate was found to be greater in NiTi coatings than in 316 SS coatings, and the impact was amplified by the addition of boron.
AtıfScopus6WoS4OpenAlex7İncele