Yazarlar
- Gul, Muhammet(35)
- Erten, Fusun(23)
- Zengin, Gokhan(23)
- Benzer, Fulya(22)
- Dal, Nursel Alp(20)
- Sahin, Kazim(20)
- Orhan, Cemal(19)
- Yeşiltepe, Akgün(17)
- Topal, Murat(15)
- Yucesan, Melih(15)
- Yildirim, Ozal(13)
- Öbek, Erdal(13)
- Aksakal, B.(12)
- Gürarslan Baş, Nazan(12)
- Alp Dal, Nursel(11)
- Baloglu, Ulas Baran(11)
- Cakilcioglu, Ugur(11)
- Kandemir, Fatih Mehmet(11)
- Paksoy, Mehmet Yavuz(11)
- Talo, Muhammed(11)
- Celik, Erkan(10)
- Er, Besir(10)
- Say, Yakup(10)
- Yaman, Mine(10)
- Yüksekol, Özlem Doğan(10)
- Aksu, Önder(9)
- Aslan, N.(9)
- Aslan, Naim(9)
- Baş, Kazım(9)
- Erişir, Mine(9)
- Mahomoodally, Mohamad Fawzi(9)
- Acharya, U. Rajendra(8)
- Caprioli, Giovanni(8)
- Karatay, Gülnaz(8)
- Kocabaş, Mehmet(8)
- Macit, Arife(8)
- Parlak Ak, Tuba(8)
- İpek, Yeliz(8)
- Beydağ, Kerime Derya(7)
- Camas, Mustafa(7)
Yayınlar
- MakaleAçık Erişim2023Scopus SJRQ3Morpho-structural and compressive mechanical properties of graphene oxide reinforced hydroxyapatite scaffolds for bone tissue applications
Fidan, Ferzan; Aslan, Naim; Koç, Mümin Mehmet
Hydroxyapatite (HA) is a unique material that has the potential to be used to replace bones and teeth in the field of orthopedics and dentistry since HA exhibits quite similar biological and chemical characteristics to human bone. Hydroxyapatite ceramics are bioactive materials used to repair damaged human tissue. The pores in the porous hydroxyapatite ceramics provide a mechanical interlock, enabling a solid bond and fixation between the implant and bone. In this study, 0.5wt%, 1wt%, and 1.5wt% graphene oxide (GO) reinforced porous HA structures were obtained using the space-holder method to increase the strength of hydroxyapatite with low mechanical strength. NaCl was used as a spacer, and PEG 400 as a binder. Scaffold structures with 40% porosity rates were sintered at 1000 °C under vacuum. Finally, a compression test was applied to the samples which were previously analyzed by SEM, EDS and XRD. The compressive strengths of 0.5%, 1%, and 1.5% graphene oxide reinforced porous HA samples were determined between 8.04 and 31.14 MPa. The highest compressive strength was recorded as 31.14 MPa in the 1% GO added sample, and the lowest compressive strength was recorded as 8.04 MPa in the 1.5% GO added sample. In addition, it was understood that the mechanical properties did not increase regularly with the increase of graphene oxide reinforcing.
AtıfScopus4OpenAlex3
İncele - MakaleYalnız künye2023Scopus SJRQ2Investigation of Antimicrobial, Anti-Quorum Sensing, and Cytotoxic Activities of Flavonoids Isolated from Pulicaria armena Boiss. & Kotschy ex Boiss. (Asteraceae)
Başpınar, Yasemin; Gürbüz, Perihan; Dilem Doğan, Şengül; Gözde Gündüz, Miyase; Aleksic, Ivana; Vojnovic, Sandra; Nikodinovic-Runic, Jasmina; Yavuz Paksoy, Mehmet
This is the first report on the separation and biological assessment of all metabolites derived from Pulicaria armena (Asteraceae) which is an endemic species narrowly distributed in the eastern part of Turkey. The phytochemical analysis of P. armena resulted in the identification of one simple phenolic glucoside together with eight flavon and flavonol derivatives whose chemical structures were elucidated by NMR experiments and by the comparison of the spectral data with the relevant literature. The screening of all molecules for their antimicrobial, anti-quorum sensing, and cytotoxic activities revealed the biological potential of some of the isolated compounds. Additionally, quorum sensing inhibitory activity of quercetagetin 5,7,3’ trimethyl ether was supported by molecular docking studies in the active site of LasR which is the primary regulator of this cell-to-cell communication system in bacteria. Lastly, the critical molecular properties indicating drug-likeness of the compounds isolated from P. armena were predicted. As microbial infections can be a serious problem for cancer patients with compromised immune systems, this comprehensive phytochemical research on P. armena with its anti-quorum sensing and cytotoxic compounds can provide a new approach to the treatment.
AtıfScopus1OpenAlex1
İncele - MakaleYalnız künye2023Scopus SJRQ1In-vitro corrosion and surface properties of PVD-coated β-type TNTZ alloys for potential usage as biomaterials: Investigating the hardness, adhesion, and antibacterial properties of TiN, ZrN, and CrN film
Ali, L.A.; Dikici, B.; Aslan, N.; Yilmazer, Y.; Sen, A.; Yilmazer, H.; Niinomi, M.
In this study, the corrosion and surface properties of non-toxic and non-allergenic β-type Ti–29Nb–13Ta–4.6Zr alloys (TNTZ) coated with TiN, ZrN, and CrN layers using the PVD technique were investigated under in-vitro conditions. The coatings' hardness, adhesion resistance, and antibacterial properties were also studied, with a focus on their potential usage as biomaterials. The corrosion tests were conducted using potentiodynamic polarization, the hardness tests were conducted using the Knoop method, and the adhesion tests were conducted using pull-off tests. The wetting properties of the coatings were examined through contact angle and 3D morphological analysis. The coatings were characterized using SEM-EDS and XRD. The results showed that the adhesion resistance of all coatings was significantly higher than the expected adhesion strength for biomaterial coatings, while their corrosion resistance was higher compared to the uncoated alloy. Besides, the study demonstrates the potential of TiN, ZrN, and CrN coatings on β-type TNTZ for use as a biomaterial with desirable surface and antibacterial properties.
AtıfScopus29OpenAlex27İncele - MakaleYalnız künye2023Scopus SJRQ2Antibacterial activity of novel synthesized chitosan-graft-poly(N-tertiary butylacrylamide)/neodymium composites for biomedical application
Yazdıç, Ferit Can; Karaman, Altuğ; Torğut, Gülben; Ayhan, Nagihan Karaaslan
In this present study, composites of chitosan-graft-poly(N-tertiary butylacrylamide) (CH-graft-poly(N‑tert‑BAAm)) copolymer, with Neodymium (Nd), an important rare earth element, were prepared by precipitation technique. Nd was successfully incorporated into the polymer of different weight percentages (0.5%, 1%, and 2%) without any degradation. The effect of neodymium additives on the structural, morphological, and antibacterial activities against gram-positive bacteria and gram-negative bacteria of the polymer was analyzed using various instrument techniques. X-ray diffraction (XRD) results together with Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) studies confirmed the morphology of Nd-doped CH-graft-poly(N‑tert‑BAAm) composites without any other impurities. The antibacterial effect of Nd was studied by adding it to the copolymer in a weight ratio of 0.5%–2%. The antibacterial effect of neodymium concentration on four different strains of bacteria was investigated: Escherichia coli (ATCC 25922) (E. coli), Pseudomonas aeruginosa (DSM 50071) (P. aeruginosa), Bacillus subtilis (DSM 1971) (B. subtilis), and Staphylococcus aureus subsp. aureus (ATCC 25923) (S. aureus). The antibacterial activities of the obtained composites were determined using the Agar Well Diffusion Assay Method. Experimental results show that Nd binds well to CH-graft-poly(N‑tert‑BAAm). Activity against E. coli, P. aeruginosa, B. subtilis, and S. aureus subsp. aureus creates a potential for pharmaceutical and biomedical applications.
AtıfScopus8WoS7OpenAlex8İncele - MakaleAçık Erişim2023Scopus SJRQ1Bioaccumulation Pattern and Health Risk Assessment of Heavy Metals in Cirrhinus mrigala at Panjnad Headworks, Bahawalpur, Pakistan
Naz, Saima; Chatha, Ahmad Manan Mustafa; Danabas, Durali; Khan, Muhammad Farhan; Xu, Youhou; Zhu, Peng; Shafique, Laiba
Heavy metal accumulation in freshwater ecosystem has become one of the major aquatic environmental concerns for freshwater flora and fauna due to their higher stability and bioaccumulation as well as bio-magnification properties. Furthermore, passing through the food web, these heavy metals affect human populations ultimately. This study assessed the heavy metal accumulation in Cirrhinus mrigala in spring, autumn, and winter at different locations (I, II, and III) of Panjnad headwork. Furthermore, the human health risk assessment for the consumption of C. mrigala from the sampling locations was also carried out. Fish were collected from upper (I), middle (II), and lower (III) stream of Panjnad on a monthly basis. The current study evaluated the accumulation of Aluminum (Al), Arsenic (As), Barium (Ba), and Lead (Pb) in various fish organs (liver, kidney, gills, fins, skin, muscles and bones) and assessed their potential hazard to human health through health risk assessment indicators. The results demonstrated a significant difference (p < 0.05) in heavy metal accumulation in different fish organs, seasons, and locations. The accumulation of Al, As, Ba, and Pb were considerably higher in liver and kidney as compared to the other body organs and followed a trend of liver > kidney > gills > fins > skin > bones > muscle and the overall mean concentrations of metals in different body tissues of C. mrigala were in the order of Al > As > Ba > Pb. The results also concluded that C. mrigala caught from the Panjnad headwork is not safe for human consumption due to higher values of TTHQIng (3.76), THQIng for Ba (3.27) and CRIng for As (6.4742).
AtıfScopus27OpenAlex25İncele - MakaleAçık Erişim2023Scopus SJRQ2ResMIBCU-Net: an encoder–decoder network with residual blocks, modified inverted residual block, and bi-directional ConvLSTM for impacted tooth segmentation in panoramic X-ray images
Imak, Andaç; Çelebi, Adalet; Polat, Onur; Türkoğlu, Muammer; Şengür, Abdulkadir
Objective: Impacted tooth is a common problem that can occur at any age, causing tooth decay, root resorption, and pain in the later stages. In recent years, major advances have been made in medical imaging segmentation using deep convolutional neural network-based networks. In this study, we report on the development of an artificial intelligence system for the automatic identification of impacted tooth from panoramic dental X-ray images. Methods: Among existing networks, in medical imaging segmentation, U-Net architectures are widely implemented. In this article, for dental X-ray image segmentation, blocks and convolutional block structures using inverted residual blocks are upgraded by taking advantage of U-Net’s network capacity-intensive connections. At the same time, we propose a method for jumping connections in which bi-directional convolution long short-term memory is used instead of a simple connection. Assessment of the proposed artificial intelligence model performance was evaluated with accuracy, F1-score, intersection over union, and recall. Results: In the proposed method, experimental results are obtained with 99.82% accuracy, 91.59% F1-score, 84.48% intersection over union, and 90.71% recall. Conclusion: Our findings show that our artificial intelligence system could help with future diagnostic support in clinical practice.
AtıfScopus21OpenAlex23İncele - MakaleAçık Erişim2023Scopus SJRQ1Adding New Scientific Evidences on the Pharmaceutical Properties of Pelargonium quercetorum Agnew Extracts by Using In Vitro and In Silico Approaches
Chiavaroli, Annalisa; Libero, Maria Loreta; Di Simone, Simonetta Cristina; Acquaviva, Alessandra; Nilofar; Recinella, Lucia; Leone, Sheila; Brunetti, Luigi; Cicia, Donatella; Izzo, Angelo Antonio
Pelargonium quercetorum is a medicinal plant traditionally used for treating intestinal worms. In the present study, the chemical composition and bio-pharmacological properties of P. quercetorum extracts were investigated. Enzyme inhibition and scavenging/reducing properties of water, methanol, and ethyl acetate extracts were assayed. The extracts were also studied in an ex vivo experimental model of colon inflammation, and in this context the gene expression of cyclooxygenase-2 (COX-2) and tumor necrosis factor α (TNFα) were assayed. Additionally, in colon cancer HCT116 cells, the gene expression of transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), possibly involved in colon carcinogenesis, was conducted as well. The extracts showed a different qualitative and quantitative content of phytochemicals, with water and methanol extracts being richer in total phenols and flavonoids, among which are flavonol glycosides and hydroxycinnamic acids. This could explain, at least in part, the higher antioxidant effects shown by methanol and water extracts, compared with ethyl acetate extract. By contrast, the ethyl acetate was more effective as cytotoxic agent against colon cancer cells, and this could be related, albeit partially, to the content of thymol and to its putative ability to downregulate TRPM8 gene expression. Additionally, the ethyl acetate extract was effective in inhibiting the gene expression of COX-2 and TNFα in isolated colon tissue exposed to LPS. Overall, the present results support future studies for investigating protective effects against gut inflammatory diseases.
AtıfScopus35OpenAlex35İncele - MakaleYalnız künye2023Scopus SJRQ4The Effect of Self-Esteem on Loneliness in Individuals With Schizophrenia
Üşenmez, Tülay Yıldırım; Budak, Funda Kavak; Ayhan, Mehmet Osman
The aim of this study was to evaluate the effect of self-esteem on loneliness in persons with schizophrenia. This study was conducted between August 2020 and August 2021 at a community mental health center affiliated with a research and training hospital in Turkey. This was a cross-sectional study that included 100 individuals with schizophrenia. A Descriptive Characteristics Form (DCF), the Rosenberg Self-Esteem Scale (RSES), and the University of California Los Angeles Loneliness Scale (UCLA-LS) were used for data collection. The individuals’ total mean scores were 2.47 ± 1.24 for RSES and 56.42 ± 10.00 for UCLA-LS. A moderate negative correlation was found between these scores (r =-0.526, P < 0.01). The results revealed that the persons with schizophrenia had a moderate level of self-esteem and a high level of loneliness, possibly indicating that as self-esteem increases, loneliness levels may decrease.
- MakaleAçık Erişim2023Scopus SJRQ1Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from Nepeta italica
Acquaviva, Alessandra; Di Simone, Simonetta Cristina; Nilofar; Bouyahya, Abdelhakim; Zengin, Gokhan; Recinella, Lucia; Leone, Sheila; Brunetti, Luigi; Uba, Abdullahi Ibrahim; Guler, Osman
Plants from the Nepeta genus have been proved to possess different pharmacological properties, among which are antimicrobial, antioxidant, anti-inflammatory, analgesic, and cytotoxic effects. Nepeta italica is a medicinal plant traditionally used for its analgesic effects, and in the present study, the phytochemical composition and biological effects of hexane, dichloromethane (DCM), ethyl acetate (EA), ethanol, ethanol-water, and water extracts of the aerial parts were investigated for determining phenolic composition, antioxidant effects, and anti-inflammatory effects in isolated mouse colon specimens exposed to lipopolysaccharide (LPS). Polar extracts were the richest in terms of phenolic compounds, especially rosmarinic acid. In parallel, ethanol, ethanol-water, and water extracts were also the most effective as scavenging/reducing and enzyme inhibition agents, especially towards cholinesterases and α-glucosidase, and in inhibiting the LPS-induced cyclooxygenase-2 (COX-2) and tumor necrosis factor α (TNFα) gene expression in mouse colon. This poses the basis for future in vivo investigations for confirming the protective effects of polar extracts of N. italica against inflammatory bowel diseases.
AtıfScopus31OpenAlex31İncele - MakaleAçık Erişim2023Scopus SJRQ1Lutein/Zeaxanthin Isomers and Quercetagetin Combination Safeguards the Retina from Photo-Oxidative Damage by Modulating Neuroplasticity Markers and the Nrf2 Pathway
Sahin, Emre; Orhan, Cemal; Sahin, Nurhan; Padigaru, Muralidhara; Morde, Abhijeet; Lal, Mohan; Dhavan, Nanasaheb; Erten, Fusun; Bilgic, Ahmet Alp; Ozercan, Ibrahim Hanifi
Exposure to light-emitting diode (LED) light is a primary cause of retinal damage, resulting in vision loss. Several plant-derived substances, such as lutein and quercetagetin (QCG), show promise in supporting eye health. In this study, the impact of lutein/zeaxanthin (L/Z, Lutemax 2020) and QCG were evaluated individually and together in a rat model of LED-induced retinal damage. A total of 63 Wistar rats were allocated into nine groups (n = 7). For 28 days, the rats received L/Z (10 or 20 mg/kg BW), quercetin (QC, 20 mg/kg BW), QCG (10 or 20 mg/kg BW), or a mixture of different lutein and QCG dosages, after which they were exposed to LED light for 48 h. LED exposure led to a spike in serum malondialdehyde (MDA) and inflammatory cytokines, as well as an increase in retinal NF-κB, ICAM, GFAP, and MCP-1 levels (p < 0.0001 for all). It also reduced serum antioxidant enzyme activities and retinal Nrf2, HO-1, GAP43, NCAM, and outer nuclear layer (ONL) thickness (p < 0.0001 for all). However, administering L/Z and QCG, particularly a 1:1 combination of L/Z and QCG at 20 mg/kg, effectively reversed these changes. The treatment suppressed NF-κB, ICAM, GFAP, and MCP-1 while enhancing Nrf2, HO-1, GAP43, and NCAM and preventing ONL thickness reduction in LED-induced retinal damage rats. In conclusion, while LED light exposure caused retinal damage, treatment with L/Z, QC, and QCG, particularly a combined L/Z and QCG regimen, exhibited protective effects on the retina. This is possibly due to the modulation of neuroplasticity markers and nuclear transcription factors in the rats’ retinal cells.
AtıfScopus22OpenAlex22İncele - MakaleYalnız künye2023Scopus SJRQ2Novel electrochemical sensor of nebivolol drug used for treatment of hypertension and chronic heart failure
İpek, Yeliz; Koçak, Berna
Nebivolol is a beta-blocker used to treat high blood pressure and heart failure. Nebivolol is a cardiovascular drug in the group of selective beta-blockers (with selective action on the cardiovascular system). It prevents the increase in heart rate and controls the pumping power of the heart. It also has a dilating effect on blood vessels and helps to lower blood pressure with this effect. The ability to analyze nebivolol quickly, simply, economically and reliably is of high importance in two cases. The first is to adjust the drug dosage to be used by the patients, and the second is to provide fast intervention in the drug production process as a result of fast and accurate quality control in drug production and to provide quality control of produced tablets. Since, the boric acid has a good catalytic activity and enhances the peak current intensity, a boric acid‒glutardialdehyde-modified glassy carbon electrode was designed for investigation of electrochemical behavior and quantitative determination of nebivolol (NBV) in this study. Electrochemical reaction peak and the peak current intensity changes with changing NBV concentration provide detection of NBV. The role of glutardialdehyde was to immobilize the boric acid on the electrode surface with its crosslinking ability. The designed electrode was achieved by dropping boric acid‒glutardialdehyde mixture on glassy carbon electrode and drying it at room conditions. By using boric acid‒glutardialdehyde-modified glassy carbon electrode (BA‒GA2/GCE), quantitative analysis of the active drug ingredient (NBV), which is widely used in the treatment of hypertension and chronic heart failure, was carried out sensitively, selectively and at low detection limits with low cost. This electrode exhibited good repeatability and stability for detection of the oxidation peak of NBV. In addition, the working ranges and detection limits of NBV were determined in the optimum experimental conditions. SWV technique was used and according to the results obtained, LOD values for NBV in BR buffer (pH 9) and in urine samples were 1.0 × 10−7 mol L−1 and 4.12 × 10−7 mol L−1, respectively. The feasibility of the developed novel sensor was demonstrated by performing recovery studies with tablet and urine samples containing NBV. The recovery results were 93.10% and 58.16% for urine and tablet samples, respectively. Graphical abstract: [Figure not available: see fulltext.]
AtıfScopus5WoS5OpenAlex5İncele - MakaleAçık Erişim2023Scopus SJRQ4Nurses’ Opinions About Patient Restraint Methods in a Psychiatric Hospital and Their Ethical Sensitivity
Durmaz, Yadigar Çevik; Ersöğütçü, Filiz
Methods of restraint can be used to prevent hospitalized psychiatric patients from injuring themselves or others, but use of restraints causes various ethical problems in psychiatric nursing. This study examined the relationship between nurses’ sociode-mographic characteristics, types of restraint methods used, nurses’ opinions about those methods, and their level of ethical sensitivity toward their use. We found the moral sensitivity of our participants to be moderate, and sta-tistically significant differences were found related to marital status, shift type, and restraint method used. Based on our results, we recommend improving nurses’ working conditions, increas-ing their level of ethical knowledge, and expanding the number of stud-ies on these issues.
AtıfScopus1WoS1OpenAlex2İncele - MakaleAçık Erişim2023Scopus SJRQ1Deep learning based hybrid prediction model for predicting the spread of COVID-19 in the world's most populous countries
Utku, Anil
COVID-19 has a disease and health phenomenon and has sociological and economic adverse effects. Accurate prediction of the spread of the epidemic will help in the planning of health management and the development of economic and sociological action plans. In the literature, there are many studies to analyse and predict the spread of COVID-19 in cities and countries. However, there is no study to predict and analyse the cross-country spread in the world's most populous countries. In this study, it was aimed to predict the spread of the COVID-19 epidemic. The motivation of this study is to reduce the workload of health workers, take preventive measures and optimize health processes by predicting the spread of the COVID-19 epidemic. A hybrid deep learning model was developed to predict and analyse COVID-19 cross-country spread and a case study was carried out for the world's most populous countries. The developed model was tested extensively using RMSE, MAE and R2. The experimental results showed that the developed model was more successful in predicting and analysis of COVID-19 cross-country spread in the world's most populous countries than LR, RF, SVM, MLP, CNN, GRU, LSTM and base CNN-GRU. In the developed model, CNN performs convolution and pooling operations to extract spatial features from the input data. GRU provides learning of long-term and non-linear relationships inferred by CNN. The developed hybrid model was more successful than the other models compared, as it enabled the effective features of the CNN and GRU models to be used together. The prediction and analysis of the cross-country spread of COVID-19 in the world's most populated countries can be presented as a novelty of this study.
AtıfScopus23WoS20OpenAlex31İncele - MakaleAçık Erişim2023Scopus SJRQ1DEEP LEARNING BASED AN EFFICIENT HYBRID PREDICTION MODEL FOR COVID-19 CROSS-COUNTRY SPREAD AMONG E7 AND G7 COUNTRIES
Utku, Anil
The COVID-19 pandemic has caused the death of many people around the world and has also caused economic problems for all countries in the world. In the literature, there are many studies to analyze and predict the spread of COVID-19 in cities and countries. However, there is no study to predict and analyze the cross-country spread in the world. In this study, a deep learning based hybrid model was developed to predict and analysis of COVID-19 cross-country spread and a case study was carried out for Emerging Seven (E7) and Group of Seven (G7) countries. It is aimed to reduce the workload of healthcare professionals and to make health plans by predicting the daily number of COVID-19 cases and deaths. Developed model was tested extensively using Mean Squared Error (MSE), Root Mean Squared Error (RMSE), Mean Absolute Error (MAE) and R Squared (R2). The experimental results showed that the developed model was more successful to predict and analysis of COVID-19 cross-country spread in E7 and G7 countries than Linear Regression (LR), Random Forest (RF), Support Vector Machine (SVM), Multilayer Perceptron (MLP), Convolutional Neural Network (CNN), Recurrent Neural Network (RNN) and Long Short-Term Memory (LSTM). The developed model has R2 value close to 0.9 in predicting the number of daily cases and deaths in the majority of E7 and G7 countries.
AtıfScopus9OpenAlex11İncele - MakaleYalnız künye2023Scopus SJRQ1Cytoprotective, antimutagenic/antirecombinogenic and antibacterial properties of Lallemantia iberica extracts
Yilmaz Kardas, Begumhan; Diken, Mehmet Emin; Bayhan, Hamza; Acar, Mikail; Dogan, Serap
BACKGROUND: Plants have important chemical compounds to protect organisms from many mutagens but they may also have dangerous toxic substances that must be tested before use. Lallemantia iberica has been used by local people for treatment of some diseases but it was never tested for its cell protective and antimutagenic/antirecombinogenic properties. In this study, it was aimed to determine the cytoprotective, antimutagenic/antirecombinogenic, antibacterial, antioxidant and phenolic profile of L. iberica by MTS assay, micronucleus test/somatic mutation recombination test (SMART), disc diffusion method, ABTS/DPPH tests and liquid chromatography (LC), respectively. RESULTS: MTS assay results showed that both of the extracts supported the normal growth of healthy human lymphocytes and there was no significant difference between extracts. Although there was no significant increase in micronucleus concentration (‰) of the cultures treated with ethanol or methanol extracts, methanol extract caused slightly lower micronucleus concentration (12.64 ± 3.65‰) than the ethanol extract (24.46 ± 4.50‰). SMART results showed that ethanol and methanol extracts prevented harmful mitotic recombination. Lallemantia iberica also showed antibacterial activity against all of the strains tested, and the largest inhibition zones were observed with Pseudomonas aeruginosa (17.9 mm) and Enterobacter aerogenes (13.8 mm). Methanol extracts showed better antioxidant activities (ABTS IC50: 104.07 μg mL−1, DPPH IC50: 58.8 μg mL−1) than ethanol extracts (ABTS IC50: 344.03 μg mL−1, DPPH IC50: 233.7 μg mL−1). According to the LC results, the most abundant phenolic compounds were rutin hydrate (1796.4 ± 62.9 mg kg−1) and p-coumaric acid (228.1 ± 7.60 mg kg−1). CONCLUSION: Lallemantia iberica extracts had cell-protective, antimutagenic/antirecombinogenic, antibacterial and strong antioxidant characteristics in relation to their rich phenolic content.
AtıfScopus7WoS5OpenAlex9İncele - MakaleAçık Erişim2023Scopus SJRQ4The Effects of Perineal Massage Performed During Labor on Childbirth Comfort, Perineal Pain, and Trauma in Nulliparous Women: A Quasi-Experimental Study
Yaşar Yetişmiş, Habibe; Aksoy Derya, Yeşim
Objective: The purpose of this study was to examine the effects of perineal massage performed during labor on childbirth comfort, perineal pain, and genital tract trauma in nulliparous women. Material and Methods: This is a quasi-experimental study with a control group. The sample consisted of a total of 182 pregnant women, including 91 in the experimental group and 91 in the control group. Perineal massage was performed in the experimental group two, four, and four to six times during the latent, active, and transition phases, respectively. The participants in the experimental group continued to receive perineal massage with every push throughout the second stage of labor. Data were collected using the “Personal Introductory Form”, “Visual Analog Scale (VAS)”, “REEDA Scale” and “Childbirth Comfort Questionnaire (CCQ)”. Results: There was a statistically significant difference between the groups in terms of labor conditions including duration of the second stage of labor, perineal trauma status, severity of perineal trauma, and episiotomy application status (p<0.05). After perineal massage, the CCQ mean score at the end of the active phase was 30.53±8.78 in the experimental group and 26.83±7.78 in the control group (p<0.05). Additionally, the postpartum VAS mean score was 3.04±2.08 in the experimental group and 5.72±2.64 in the control group (p<0.001). The REEDA mean total score was 3.23±0.53 in the experimental group and 5.50±1.70 in the control group (p<0.001). Conclusion: Perineal massage administered to nulliparous women during labor increased childbirth comfort and decreased perceptions of perineal pain, and it was associated with lower rates of genital tract trauma.
AtıfOpenAlex1İncele - MakaleYalnız künye2023Scopus SJRQ1The relationship between unemployment anxiety, job satisfaction and migration attitude among the next generation of Turkish nurses: A cross-sectional study
Öncü, Emine; Köksoy Vayısoğlu, Sümbüle; Karadağ, Gülendam; Şahin Orak, Nuray; Selçuk Tosun, Alime; Yüksekol, Özlem Doğan; Çatıker, Aslıhan; Yalçın, Gülcan Çiftçioğlu
Background: The global nursing shortage is complex and multifaceted. Despite the policy of increasing the number of nurses, concerns about the sustainability of the nursing workforce in Turkey continue. Aim: To evaluate the relationship between unemployment anxiety, job satisfaction, and migration attitudes among Turkish nursing candidates. Methods: A cross-sectional study was conducted with 1100 nursing candidates between April and June 2022. The data gathered from the “Personal Form, Job Satisfaction, and Brain Drain Attitudes Scale” were analyzed using logistic regression and decision tree analysis. Results: Of the participants, 67.1% were female, and the mean age was 22.6 ± 1.7 years. Being male (OR = 1.317, 95% Cl 0.994–1.743) having a low income (OR = 1.754, 95% Cl 1.334–2.306), feeling insecure about the future (OR = 2.340, 95% Cl 1.312–4.175), expecting a lower wage than desired (OR = 2.015, 95% Cl 1.132–3.586), and employment precariousness (OR = 1.786, 95% Cl 1.355–2.353) increase the possibility of experiencing high unemployment anxiety. On the other hand, family support for living abroad (OR = 0.579, 95% CI 0.408–0.821) and job satisfaction (OR = 0.799, 95% CI 0.692–0.921) decrease unemployment anxiety (p < 0.05). According to the results of the decision tree analysis, the host country's pull factors are the best predictors of the nursing candidates' intention to work abroad as nurses (p < 0.05). Conclusion: The increasing prevalence of unemployment anxiety and migration tendencies among nursing candidates requires the evaluation of policies aimed at increasing the number of nursing graduates in Turkey.
AtıfScopus9OpenAlex16İncele - MakaleYalnız künye2023Scopus SJRQ2Genotoxic effect of iron oxide (Fe2O3) nanoparticles on Triticum aestivum (wheat)
Tasar, Neslihan
Industrial activities and unconscious consumption of natural resources cause environmental pollution with the rapid increase in the world population. As a result of the widespread use of iron oxide nanoparticles (Fe2O3 NP) with nano-industrial activities, it is predicted that this NP will accumulate in the air, water, and soil. In the present study, the purpose was to find out the genotoxic effects on root meristem cells of the Triticum aestivum L. plant, which is an indicator organism exposed to 20–40 nm Fe2O3 NPs at different concentrations (100, 200, and 400 ppm). The amount of Fe2O3 NP accumulated in T. aestivum used in the study was determined with x-ray diffraction (XRD) spectroscopy, scanning electron microscopy (SEM), SEM element map, and EDS characteristic spectrum. All concentrations of Fe2O3 NP caused significant decreases in the mitotic index. Fe2O3 NPs significantly increased the frequency of mitotic abnormalities in T. aestivum root tip cells at all treatment times and all concentrations when compared to the control. Fe2O3 NPs were formed by various mitotic abnormalities such as loss of genetic material, deconstructed prophase, adhesion, chromosome groupings in metaphase, deconstructed metaphase, C-Metaphase, chromosomal loss, chromosomal fracture, polyploidy, deconstructed anaphase, lagging chromosome, fragment, polar deviation, bridging, propagation, asynchronous division, star anaphase, multipolarity, and deconstructed telophase. All these results show that Fe2O3 NPs are genotoxic and clastogenic and may also cause DNA damage. Briefly, these data show that Fe2O3 NPs taken by organisms may pose a danger to the organism and the upper consumer. These findings also show that the production and use of Fe2O3 NPs, which affect organisms, must be controlled, and ultimately, be safely disposed of to reduce their bioaccumulation. Research Highlights: In the present study, the purpose was to find out the genotoxic effects on root meristem cells of the Triticum aestivum L. (bread wheat) plant, which is an indicator organism exposed to 20–40 nm Fe2O3 NPs at different concentrations (100, 200, and 400 ppm). The amount of Fe2O3 NP accumulated in T. aestivum used in the study was determined with x-ray diffraction (XRD) spectroscopy, scanning electron microscopy (SEM), SEM element map, and EDS characteristic spectrum. The mitotic index was calculated to reveal the genotoxic effect. “Loss of genetic material, deconstructed prophase, adhesion, chromosome groupings in metaphase, deconstructed metaphase, C-Metaphase, chromosomal loss, chromosomal fracture, polyploidy, deconstructed anaphase, lagging chromosome, fragment, polar deviation, bridging, propagation, asynchronous division, star Chromosomal abnormalities such as anaphase, multipolarity, and deconstructed telophase” were visualized. Fe2O3 NPs are genotoxic and clastogenic and may also cause DNA damage.
AtıfScopus10WoS7OpenAlex11İncele - MakaleAçık Erişim2023Scopus SJRQ2Fabrication of hydroxyapatite-based nano-gold and nano-silver-doped bioceramic bone grafts: Enhanced mechanostructure, cell viability, and nuclear abnormality properties
Demirel, M.; Aslan, N.; Aksakal, B.; Arslan, M.E.
In this study, nano-gold (nAu) and nano-silver (nAg) were doped at the molar ratios of Molar5–Molar30 to the Hydroxyapatite (HAp)-based bioceramic bone graft synthesized by the sol–gel method. The effects of nAu and nAg on structural, mechanical, cell viability, and nuclear abnormality of the synthesized bioceramic grafts were evaluated. The chemical and morphological properties of the bone grafts after production were examined through XRD and SEM–EDX analyses and mechanical tests. To determine the biocompatibility of the bone grafts, cell viability tests were performed using human fibroblast cells. In the cytotoxicity analyses, only HAp and HAp-nAu5 grafts did not show toxicological properties at any concentration, while HAp-nAg5 among the nAg-containing grafts gave the best results at the 200–100 μg/mL concentrations and showed significant cytotoxicity in human fibroblast cells. The other nAu-containing grafts showed toxicological properties in the concentration range of 200–50 μg/mL and nAg-containing grafts in the concentration range of 200–100 μg/mL against the negative control. The micronucleus (MN) analyses showed that the lowest total MN and L (lobbed) amounts, while the lowest total N (notched) amount, was obtained from the only HAp graft. It was found that the nAg-doped bone grafts gave higher total MN, L, and N amounts compared to the nAu-doped bone grafts. Furthermore, while the mean nuclear abnormality (NA) values of all grafts gave close results, the highest values were again obtained from the nAg-doped bone grafts.
AtıfScopus7WoS6OpenAlex9İncele - MakaleAçık Erişim2023Scopus SJRQ3WEAR AND ADHESION PROPERTIES OF MULTILAYER Ti/TiN, (/TiC)/ TiCN/ TaN THIN FILMS DEPOSITED ON Ti13Nb13Zr ALLOY BY CLOSED FIELD UNBALANCED MAGNETRON SPUTTERING
Aslan, Ali Kemal; Bahçe, Erkan
Ti13Nb13Zr alloy stands out as an alternative to Ti6Al4V alloy for orthopaedic joint implant applications due to its low modulus of elasticity, high mechanical properties, high corrosion resistance, high biocompatibility and low modulus of elasticity, as well as con-taining no cytotoxic elements. In this study, Ti13Nb13Zr alloy was coated with TiN/TiC/TiCN/TaN multilayer thin films by pulsed-dc CFBUMS method to increase wear resistance and improve surface properties. Characterization of the deposited films were con-ducted by XRD, SEM, AFM, pin-on-disk, progressive scratch experiments. As a result, it is observed that all the coatings enhanced the tribological properties of the Ti13Nb13Zr alloy surface. The 20-layer TiN/TiC/TiCN/TaN multilayer coatings gave the best results for wear resistance and adhesion properties. Enhancing the interlayer number resulted in increased wear and adhesion resistance. In addition, it was determined that using TiC instead of TiN in the interlayers gave higher results regarding adhesion, wear, and mechanical properties.
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