Yazarlar
- Gul, Muhammet(35)
- Erten, Fusun(23)
- Zengin, Gokhan(23)
- Benzer, Fulya(22)
- Dal, Nursel Alp(20)
- Sahin, Kazim(20)
- Orhan, Cemal(19)
- Yeşiltepe, Akgün(17)
- Topal, Murat(15)
- Yucesan, Melih(15)
- Yildirim, Ozal(13)
- Öbek, Erdal(13)
- Aksakal, B.(12)
- Gürarslan Baş, Nazan(12)
- Alp Dal, Nursel(11)
- Baloglu, Ulas Baran(11)
- Cakilcioglu, Ugur(11)
- Kandemir, Fatih Mehmet(11)
- Paksoy, Mehmet Yavuz(11)
- Talo, Muhammed(11)
- Celik, Erkan(10)
- Er, Besir(10)
- Say, Yakup(10)
- Yaman, Mine(10)
- Yüksekol, Özlem Doğan(10)
- Aksu, Önder(9)
- Aslan, N.(9)
- Aslan, Naim(9)
- Baş, Kazım(9)
- Erişir, Mine(9)
- Mahomoodally, Mohamad Fawzi(9)
- Acharya, U. Rajendra(8)
- Caprioli, Giovanni(8)
- Karatay, Gülnaz(8)
- Kocabaş, Mehmet(8)
- Macit, Arife(8)
- Parlak Ak, Tuba(8)
- İpek, Yeliz(8)
- Beydağ, Kerime Derya(7)
- Camas, Mustafa(7)
Yayınlar
- MakaleAçık Erişim2013Scopus SJRQ2Bioaccumulation, Subacute Toxicity, and Tissue Distribution of Engineered Titanium Dioxide Nanoparticles in Goldfish (Carassius auratus)
Ates, Mehmet; Demir, Veysel; Adiguzel, Ragip; Arslan, Zikri
The increased use of nanosized materials is likely to result in the release of these particles into the environment. It is, however, unclear if these materials are harmful to aquatic animals. In this study, the sublethal effects of exposure of low and high concentrations of titanium dioxide nanoparticles (TiO2 NPs) on goldfish (Carassius auratus) were investigated. Accumulation of TiO2 NPs increased from 42.71 to 110.68 ppb in the intestine and from 4.10 to 9.86 ppb in the gills of the goldfish with increasing exposure dose from 10 to 100mg/L TiO2 NPs. No significant accumulation in the muscle and brain of the fish was detected. Malondialdehyde as a biomarker of lipid oxidation was detected in the liver of the goldfish. Moreover, TiO2 NPs exposure inhibited growth of the goldfish. Although there was an increase (8.1%) in the body weights of the goldfish for the control group, in the low and high exposure groups 1.8% increase and 19.7% decrease were measured, respectively. The results of this study contribute to the current understanding of the potential ecotoxicological effects of nanoparticles and highlight the importance of characterization of NPs in understanding their behavior, uptake, and effects in aquatic systems and in fish.
AtıfWoS53OpenAlex80
İncele - MakaleAçık Erişim2013Scopus SJRQ3ANTIMICROBIAL ACTIVITIES OF SOME EUPHORBIA SPECIES
Kirbag, Sevda; Erecevit, Pinar; Zengin, Fikriye; Guvenc, Ayse Nilay
In this study, the antimicrobial activities of methanolic extracts and latex of some Euphorbia species used for medical purposes in Turkey were investigated. The extracts of Euphorbia aleppica L., Euphorbia szovitsii Fisch.&Mey. var. harputensis Aznav. ex M. S. Khan, Euphorbia falcata L. sub. falcata var. falcata, Euphorbia denticulata Lam., Euphorbia macroclada Boiss., Euphorbia cheiradenia Boiss.&Hohen, Euphorbia virgata Waldst.&Kit., Euphorbia petiolata Banks&Sol. were prepared with methanol. The antimicrobial activities of these extracts were examined on test microorganisms as follows: Staphylococcus aureus COWAN 1, Bacillus megaterium DSM 32, Proteus vulgaris FMC 1, Klebsiella pneumonia FMC 5, Escherichia coli ATCC 25922, Pseudomonas aeruginosa DSM 50071, Candida albicans FMC 17, Candida glabrata ATCC 66032, Epidermophyton sp. and Trichophyton sp. by the disc diffusion methods and well agar method. The MIC values of extracts were determined according to the broth microdulitions method. Results indicated that extracts of Euphorbia species inhibited the growth of tested microorganisms in the different ratio. Also, the MIC values of extracts were determined as 31,2-1000 mu g.
AtıfWoS29OpenAlex30
İncele - MakaleYalnız künye2013Scopus SJRQ2Relationship between fatigue and social support in hemodialysis patients
Karadag, Ezgi; Kilic, Serap Parlar; Metin, Ozgur
The aim of this study was to evaluate the relationship between fatigue and social support in hemodialysis patients in Turkey. This study was conducted on 73 patients receiving hemodialysis treatment in a hemodialysis unit in the province of Malatya between July and November 2011. A questionnaire consisting of 16 questions for sociodemographic and disease data was used together with the Multidimensional Scale of Perceived Social Support (MSPSS) and the Fatigue Severity Scale (FSS). In statistical evaluation, the Mann-Whitney U-test, independent t-test, Kruskal-Wallis test, and Pearson's correlation analysis were used. Correlation analysis between severity of fatigue in hemodialysis patients and social support revealed a significant relationship in the negative direction between fatigue severity and support from family (r=-0.404, P<0.05), support from friends (r=-0.635, P<0.05), support from a special person (r=-0.638, P<0.05) and overall support (r=-0.643, P<0.05). Patients with severe fatigue had low mean scores for support from family, friends, a special person and overall, whereas a high level of social support decreased the level of fatigue. When giving care to patients on hemodialysis, nurses should consider the effect of social support on fatigue and approach their patients from this perspective.
AtıfWoS27OpenAlex45İncele - MakaleAçık Erişim2013Scopus SJRQ3Determination of phytochemical characteristics of the extract of Zea mays with Saccharomyces boulardii
Erecevit, Pinar; Kirbag, Sevda; Yilmaz, Okkes
Fatty acid, vitamin, phytosterol, flavonoid, and resveratrol contents and antimicrobial activities of Zea mays L. (corn) extracts treated with Saccharomyces boulardii were determined and compared. The total fatty acid, vitamin, and phytosterol contents in corn extract were at certain levels. It was detected that total fatty acid levels and vitamin contents of corn extracts prepared with Saccharomyces boulardii increased; however, flavonoid contents decreased at different rates. In addition to this, it was observed that naringin, resveratrol, and myricetin flavonoids were present in the extracts that contained S. boulardii. In the study, it was noticed that Z. mays L. (corn) had antioxidant and antimicrobial activities at different rates. It was observed that S. boulardii developing in extracts obtained from plants affected bioactive compounds at different rates.
AtıfWoS3OpenAlex4İncele - MakaleAçık Erişim2013Scopus SJRQ3Mechanical and thermal properties of polyamide versus reinforced PMMA denture base materials
Soygun, Koray; Bolayir, Giray; Boztug, Ali
PURPOSE. This in vitro study intended to investigate the mechanical and thermal characteristics of Valplast, and of polymethyl methacrylate denture base resin in which different esthetic fibers (E-glass, nylon 6 or nylon 6.6) were added. MATERIALS AND METHODS. Five groups were formed: control (PMMA), PMMA-E glass, PMMA-nylon 6, PMMA-nylon 6.6 and Valplast resin. For the transverse strength test the specimens were prepared in accordance with ANSI/ADA specification No.12, and for the impact test ASTM D-256 standard were used. With the intent to evaluate the properties of transverse strength, the three-point bending (n=7) test instrument (Lloyd NK5, Lloyd Instruments Ltd, Fareham Hampshire, UK) was used at 5 mm/min. A Dynatup 9250 HV (Instron, UK) device was employed for the impact strength (n=7). All of the resin samples were tested by using thermo-mechanical analysis (Shimadzu TMA 50, Shimadzu, Japan). The data were analyzed by Kruskal-Wallis and Tukey tests for pairwise comparisons of the groups at the 0.05 level of significance. RESULTS. In all mechanical tests, the highest values were observed in Valplast group (transverse strength: 117.22 +/- 37.80 MPa, maximum deflection: 27.55 +/- 1.48 mm, impact strength: 0.76 +/- 0.03 kN). Upon examining the thermo-mechanical analysis data, it was seen that the E value of the control sample was 8.08 MPa, higher than that of the all other samples. CONCLUSION. Although Valplast denture material has good mechanical strength, its elastic modulus is not high enough to meet the standard of PMMA materials.
AtıfWoS67OpenAlex110İncele - MakaleAçık Erişim2012Scopus SJRQ3Determination of acute phase proteins aft er experimental Streptococcus iniae infection in tilapia (Oreochromis niloticus L.)
Güleç, Azime Kucukgul; Cengizler, Ibrahim
Tilapia (Oreochromis niloticus Linnaeus, 1758) were infected with Streptococcus iniae (Cat No: ATCC 29178) and the plasma changes in the acute phase protein (APP) members were examined at different time periods. A total of 72 fish with average body weights of 60 g were used. Fish in the infected group (group I) were intraperitoneally injected with S. iniae at 3.3 x 10(5) colony forming unit (CFU) in 0.1 mL level to the fish. The other group (group II) was subjected to handling stress near the infection. The control group was constituted by providing optimum conditions. On days 7, 14, and 21, blood samples were taken from the caudal veins of the fish under the appropriate anesthesia. The samples were examined on the basis of APPs, C-reactive protein (CRP), fibrinogen (FB), serum amyloid A (SAA), and transferrin (TF) and the changes in the plasma values were recorded. The internal and external symptoms seen during the examinations were detected as follows: the color concentration in 1-2 days in the infected groups, irregularity and retardation in the movements of the fish, hyperemic spots on the skin, and bloody effusion in the internal organs. In both of the infected groups, the CRP and SAA plasma values increased on days 7, 14, and 21 (P < 0.05). Remission was observed in the plasma TF levels in the first week; however, aft er the second week the levels reached normal values. Decreases in the FB levels of all of the samples were detected. Based on the data acquired in this study, it was concluded that changes in the plasma levels of the APP members can be used as a significant bioindicator in the pathogenesis of the disease in fish infections.
AtıfWoS9OpenAlex6İncele - MakaleYalnız künye2012Scopus SJRQ1Effectiveness of a Multistimulant Home-Based Program on Cognitive Function of Older Adults
Karatay, Gulnaz; Akkus, Yeliz
The purpose of this study was to test the effects of a multistimulant home-based program on cognitive function among older adults. This study was conducted in northeastern Turkey between March and June 2010. It was planned as an experimental versus control two-group design and carried out on 96 (intervention group = 48, control group = 48) participants. The intervention and control groups were similar regarding sex, education, partner status, and continuous drug use. Data were collected with a Standardized Mini Mental Test, the Geriatric Depression Scale (GDS), and the Beck Anxiety Scale. Each senior received a total of 10 home visits on a once-per-week basis. Results for the intervention group showed that the Mini Mental State Test scores of the participants had statistically increased, and the Beck Anxiety and the GDS scores showed a decrease. The study found an association between the multistimulant home-based intervention program and cognitive function.
AtıfWoS4OpenAlex5İncele - MakaleAçık Erişim2012Scopus SJRQ2Chemotherapeutic Agent-induced Nephrotoxicity in Rabbits: Protective Role of Grape Seed Extract
Benzer, Fulya; Kandemir, Fatih Mehmet; Ceribasi, Songul; Ozkaraca, Mustafa; Yildirim, Nuran Cikcikoglu; Ozan, Sema Temizer
Cisplatin (CP) is one of the most effective cancer chemotherapeutic agent used against various solid tumors. This study was designed to investigate the antioxidant effects of Grape Seed Extract (GSE) on CP induced oxidative damage in rabbit kidney. The material of study was consist of 18 male New Zealand rabbit. Animals were divided into 3 groups. The first group was administered a single intraperitoneal (i.p.) close of 0.9% saline. The second group of rabbits was treated with CP (a single i.p. dose of 5 mg kg(-1) body weight); The third group of rabbits was treated with GSE by gavage at the dose of 250 mg kg(-1) body weight for 6 consecutive days before and 6 consecutive days after a single i.p. CP injection. As a result of CP administration, kidney function tests; urea, BUN (Blood Urea Nitrogen) and creatinine levels were increased (p<0.001). It was observed that CP increase malondialdehide (MDA) levels, the most important indicator of oxidative damage and decreased the activity of catalasc (CAT). Administration of CP did not caused statically a change in glutathione (GSH) levels and glutathione peroxidase (GSH-P-x) activity (p>0.05). GSE treatment has high levels of MDA to compared to normal levels (p<0.001) but not an increase in CAT (p<0.05). In CP treatment group, severe acute tubular necrosis was seen. It was determined that in CP+GSE group mild degenerative changes were received instead of acute tubular necrosis. GSE has been found to be partially protective effect against CP induced biochemical and histopathological changes in rabbit kidney.
AtıfWoS7OpenAlex7İncele - MakaleAçık Erişim2012Scopus SJRQ2Changes in nitric oxide levels and erythrocyte arginase activities in patient with Down syndrome
Ozbey, Ulku; Seyran, Ayse; Erisir, Mine; Benzer, Fulya; Savucu, Yuksel
Down syndrome is a chromosome abnormality with specific clinical symptoms and mental retardation caused by trisomy of chromosome 21. There is evidence that oxygen free radicals play an important role in the pathophysiology of many neuropsychiatric disorders. Although, it has not been investigated yet, several recent studies proposed that nitric oxide related to oxidative stress and arginase may have a pathophysiological role in mental retardation. The purpose of this study was to determine plasma nitric oxide levels and erythrocyte arginase activities in patients with Down syndrome and in healthy children. Plasma nitric oxide levels and erythrocyte arginase activity were measured in 20 patients with Down syndrome (median age: 15.6 +/- 7.5) and 20 age-matched healthy subjects (median age: 16.2 +/- 7.4). Significant differences were found between erythrocyte arginase activity of the patients with Down syndrome (35.2 +/- 2.7 U/g hemoglobin (Hb)) and those of healthy children (43.5 +/- 2.9 U/g Hb), (P < 0.05). But we have not found any statistical difference between persons with Down syndrome and control group for nitric oxide (P > 0.05). It was concluded that the level of erythrocyte arginase activity could be considered as a useful marker for assessing the level of mental retardation in children with Down syndrome.
- MakaleAçık Erişim2012Scopus SJRQ2Investigation of Yersinia ruckeri Infection in Rainbow Trout (Oncorhynchus mykiss Walbaum 1792) Farms by Polymerase Chain Reaction (PCR) and Bacteriological Culture
Seker, Engin; Karahan, Murat; Ispir, Unal; Çetinkaya, Burhan; Saglam, Naim; Sarieyyüpoglu, Mustafa
This study has been carried out to investigate the presence of Yersinia ruckeri, the causative agent of Enteric Red Mouth (ERM) disease, in rainbow trout fish breeding farms located in Elazig and Malatya provinces in Eastern Turkey. For this purpose, bacteriological culture and a specific polymerase chain reaction (PCR) have been compare with examine blood and intestine samples collected from adult and young rainbow trout fish as well as water samples collected from all the farms. Y. ruckeri was isolated and identified from eight of the 17 fish farms giving a proportion of 52.9% at fish farm. The disease was noted in five of the rainbow trout farms located in Elazig and three of the 11 rainbow trout farms located in Malatya. The agent was detected in five of the six young fish breeding farms. The isolation percentages of the causative agent at fish level were calculated as 25.7% (131/510) in adult and 31.7% (19/60) in young fish, giving an overall proportion of 26.3% (150/570). All the isolates have been successfully identified as Y ruckeri by species-specific PCR. No isolation could be made from water samples. It is therefore concluded that Y. ruckeri infection poses a significant threat to the fish farms in the study area and necessary precautions should urgently be taken in order to minimize economical losses due to ERM disease. A specific PCR can be utilized successfully in aquaculture for rapid identification of bacterial agents which will help to prevent spread of infectious diseases and will therefore contribute to the productivity of fishery sector.
AtıfWoS6OpenAlex7İncele - MakaleAçık Erişim2011Assessment of Some Heavy Metals in Drinking Water Samples of Tunceli, Turkey
Kaplan, Olcay; Yildirim, Nuran Cikcikoglu; Yildirim, Numan; Tayhan, Nilgun
The drinking water quality is associated with the conditions of the water supply networks, the pollution and the contamination of groundwater with pollutants of both anthropogenic and natural origin. In this study, water samples were taken from four different waterworks in Tunceli, Turkey and heavy metals concentrations (As, Cu, Cd, Cr, Pb, Ni and Hg) were measured. Four sampling sites were pre-defined in different locations of the city. The obtained results showed that, the heavy metals concentrations in water samples did not exceed the values of WHO (World Health Organization), EC (Europe Community), EPA (Environment Protection Agency) and TSE-266 (Turkish Standard) guidelines.
AtıfWoS16OpenAlex28İncele - MakaleAçık Erişim2011Effects of Training on Womans Who Have High Risk in Terms of Indoor Environmental Air Pollution
Karatay, Gulnaz; Akkus, Yeliz
Aim: This study was conducted to determine the effects of training on women who have high risk in terms of indoor environmental air pollution in Kars. Methods: This study was planned as an intervention study and the data was collected between March 10, 2010 to March 10, 2011. The study was performed on 80 women who were trained by six visits made once in every other week at their home. Data were collected with socio-demographic form, health status information form, environmental tobacco exposure form, information form on dried cow dung usage and awareness of women, St. George Respiratory Questionnaire. Results: After the intervention, it was seen that knowledge level of women about use of dried cow dung was increased dramatically. The St. George Respiratory Questionnaire scores of these women at were 2.40 point lower in positive aspect, but the difference wasn't statistically significant. At the beginning 94.7% and after the study 72.4% of women have declared environmental smoke exposure. Conculation: After the study, it was seen that knowledge level of women about dried cow dung usage and it's harm to health as well as their efforts to improve respiratory system health were increased.
- MakaleYalnız künye2011Scopus SJRQ2Antibacterial Effects of Some Fermented Commercial and Homemade Dairy Products and 0.9% Lactic Acid against Selected Foodborne Pathogens
Yesillik, S.; Yildirim, N.; Dikici, A.; Yildiz, A.
In this study, the antibacterial effects of homemade yoghurt, commercial yoghurt, commercial kefir and probiotic yoghurt on viability of Salmonella typhimurium (ATCC 14028), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and Staphylococcus aureus (ATCC 25923) was investigated by using disc diffusion method. Antibaterial effects of the samples were tested at 24, 48 h and the 7 day intervals. Homemade yoghurt showed the maximum antibacterial effect against the pathogens. It was determined that the most sensitive pathogenic bacteria to dairy products were Salmonella typhimurium whereas the least sensitive pathogen was Pseudomonas aeruginosa. Comparing to the antimicrobial effect of 0.9% lactic acid which was used as positive control, our results concluded that the bacteria found in fermented dairy products have an antibacterial activity and this activity is not caused by only lactic acid.
AtıfWoS23OpenAlex38İncele - MakaleAçık Erişim2010Scopus SJRQ1The effect of adrenomedullin and cold stress on interleukin-6 levels in some rat tissues
Yildirim, N. C.; Yurekli, M.
P>Stress known to stimulate sympathetic activity, as well as the hypothalamic-pituitary-adrenal axis (HPA), produces a significant increase in adrenomedullin (AdM) levels, suggesting a regulatory or protective role for AdM in countering HPA activation that follows a variety of stressors. Stressors can modulate the secretion of proinflammatory cytokines. Interleukin (IL)-6 is a potent activator of the HPA and appears to play a pathogenic role in conditions related to stress. In the present study, we investigated the administration of AdM on IL-6 levels in cold exposed rats. Male Wistar rats were divided into four groups as control, adrenomedullin treatment, cold stress and cold stress+adrenomedullin-treated groups. In the adrenomedullin-treated group, animals received intraperitoneal (i.p.) injection of adrenomedullin (2000 ng/kg body weight) once a day for a week. For the cold stress exposure the rats were kept in separate cages at 10 degrees C for a week. Control group rats were kept in laboratory conditions. The concentration of IL-6 was determined using an enzyme-linked immunosorbent assay (ELISA) kit. When compared to control, IL-6 levels increased significantly in the cold stress- and adrenomedullin-treated groups (P < 0 center dot 05). Administration of AdM in addition to cold stress decreased IL-6 levels in lung and liver, but increased in brain and heart when compared to control (P < 0 center dot 05). The results suggest that cold stress may induce increase of rat proinflammatory cytokine IL-6 and adrenomedullin may play a regulatory or protective role for cold stress.
AtıfWoS24OpenAlex26İncele
