Yazarlar
- Gul, Muhammet(35)
- Erten, Fusun(23)
- Zengin, Gokhan(23)
- Benzer, Fulya(22)
- Dal, Nursel Alp(20)
- Sahin, Kazim(20)
- Orhan, Cemal(19)
- Yeşiltepe, Akgün(17)
- Topal, Murat(15)
- Yucesan, Melih(15)
- Yildirim, Ozal(13)
- Öbek, Erdal(13)
- Aksakal, B.(12)
- Gürarslan Baş, Nazan(12)
- Alp Dal, Nursel(11)
- Baloglu, Ulas Baran(11)
- Cakilcioglu, Ugur(11)
- Kandemir, Fatih Mehmet(11)
- Paksoy, Mehmet Yavuz(11)
- Talo, Muhammed(11)
- Celik, Erkan(10)
- Er, Besir(10)
- Say, Yakup(10)
- Yaman, Mine(10)
- Yüksekol, Özlem Doğan(10)
- Aksu, Önder(9)
- Aslan, N.(9)
- Aslan, Naim(9)
- Baş, Kazım(9)
- Erişir, Mine(9)
- Mahomoodally, Mohamad Fawzi(9)
- Acharya, U. Rajendra(8)
- Caprioli, Giovanni(8)
- Karatay, Gülnaz(8)
- Kocabaş, Mehmet(8)
- Macit, Arife(8)
- Parlak Ak, Tuba(8)
- İpek, Yeliz(8)
- Beydağ, Kerime Derya(7)
- Camas, Mustafa(7)
Yayınlar
- MakaleYalnız künye2023Scopus SJRQ2The effect of occupational training provided to workers in a glass factory on their use of ear protectors
Yeşiltepe, Akgün; Karadağ, Gülendam
Objectives. This study aimed to determine the effect of occupational training applied to workers working in noisy parts of a glass factory on the use of ear protectors. Methods. The study was a semi-experimental pre-test and post-test design. It was carried out with 45 workers determined by purposeful sampling and working in a glass production factory who accepted to participate in the study. The data were collected with an information form and noise-related symptom chart, hearing health information questionnaire and observation. In the analysis of the study data, the number/percentage, χ 2 test, Cohen κ test and analysis of variance were used. Results. It was determined that workers pre training did not use ear protectors (100%) and there were some noise-related health complaints. There was an increase in using ear protectors (57.8%) and a decrease in their health complaints post training. It was also found that the workers’ pre-training hearing health information questionnaire mean score was 11.46 ± 3.20, and post training was 13.77 ± 3.42 in the first month and 15.77 ± 2.88 in the fourth month. Conclusions. Occupational training provided to the workers increased the workers’ awareness level and their rate of wearing ear protectors, and health problems caused by work-related noise started to recover.
AtıfScopus1WoS1OpenAlex2
İncele - MakaleYalnız künye2023Scopus SJRQ3Nafion–Titanium (IV) Oxide-Graphene Modified Glassy Carbon Electrode (GCE) Based Electrochemical Sensor for the Voltammetric Determination of the β-blocker Bisoprolol Fumarate
Koçak, Berna; İpek, Yeliz
A Nafion–titanium (IV) oxide-graphene modified glassy carbon electrode (n-TiO2-GR/GCE) was used for the electrochemical determination of bisoprolol fumarate (BF). The modified electrode was prepared by depositing Nafion–titanium (IV) oxide-graphene onto the glassy carbon electrode by simple drop-casting. Differential pulse voltammetry (DPV) and square wave voltammetry (SWV) were used in the electrochemical determination of bisoprolol fumarate. The linear working range of bisoprolol fumarate for n-TiO2-GR/GCE DPV was from 3.0 × 10−7 to 5.0 × 10−6mol L−1 and the detection limit was 1.01 × 10−7mol L−1. In addition, with this developed method, the determination of bisoprolol fumarate in tablets was successfully performed with a recovery of 98.65%.
AtıfScopus3WoS2OpenAlex3İncele - MakaleYalnız künye2023Scopus SJRQ3Investigating the selfitis behaviors and self-esteem of nursing and medical technology students
Aslan, Sinan; Yeşiltepe, Akgün; Bülbüloğlu, Semra
Introduction: In this study, we aimed to investigate the selfitis behaviors and self-esteem of nursing and medical technology students. Material and Methods: This descriptive and cross-sectional study was conducted with the participation of 612 students studying in the departments of nursing and medical technology at a university in eastern Turkey. The non-parametric Mann-Whitney U test and Kruskal Wallis test were carried out. Results: The participants were between the ages of 18 and 24. Most of the participants in both department groups were women. More than 90% of the participants in both groups were using social media. It was determined that they used WhatsApp, Instagram, and Twitter most, and they took selfies for sharing these selfies with their friends on social media. A statistically significant negative correlation was found between the selfitis behaviors of the participants and their self-esteem levels. Conclusion: The nursing and medical technology students who participated in this study had moderate levels of selfitis behaviors and self-esteem, and there was a negative relationship between these two variables. To facilitate the socializing of students in real life, we recommend that their family and close circle support be increased. We recommend raising awareness on print and visual media regarding problematic social media usage behaviors.
AtıfOpenAlex2İncele - MakaleAçık Erişim2023Scopus SJRQ2Synthesis, structural characterizations and in vitro cytotoxic activities of new sulfonamide-based Schiff base derivatives
Şahal, Hakan; Öz, Samet; Tekin, Suat; Canpolat, Erdal
Synthesis of five different new compounds (1-5) were carried out. Their structures were characterized by spectroscopic methods such as Fourier transform infrared, Proton nuclear magnetic resonance, Carbon-13 nuclear magnetic resonance and Elemental analysis. Cytotoxic activities of five new sulfonamide based-Schiff base compounds were determined by MTT assay using A-2780 (human ovarian cancer) and MCF-7 (breast cancer) cell lines. LogIC50 values of the sulfonamide derivates compounds were calculated by Graphpad Prism 12 programme after a 24-hour treatment for A2780 and MCF-7 cells. Comet assay experiments were performed to determine DNA damage using LogIC50 concentrations of all compounds in A2780 and MCF-7 cells. All compounds significantly reduced A2780 and MCF-7 cell viability compared to control groups (p < 0.05). In addition, all compounds caused DNA damage in A2780 and MCF-7 cells (p < 0.05). These results show that the synthesized compounds exhibit cytotoxic effects against cancer cells and that the cause of cell death is due to DNA damage. Communicated by Ramaswamy H. Sarma.
AtıfScopus5WoS5OpenAlex5İncele - MakaleAçık Erişim2023Scopus SJRQ2Automated Hypertension Detection Using ConvMixer and Spectrogram Techniques with Ballistocardiograph Signals
Ozcelik, Salih T. A.; Uyanık, Hakan; Deniz, Erkan; Sengur, Abdulkadir
Blood pressure is the pressure exerted by the blood in the veins against the walls of the veins. If this value is above normal levels, it is known as high blood pressure (HBP) or hypertension (HPT). This health problem which often referred to as the “silent killer” reduces the quality of life and causes severe damage to many body parts in various ways. Besides, its mortality rate is very high. Hence, rapid and effective diagnosis of this health problem is crucial. In this study, an automatic diagnosis of HPT has been proposed using ballistocardiography (BCG) signals. The BCG signals were transformed to the time-frequency domain using the spectrogram method. While creating the spectrogram images, parameters such as window type, window length, overlapping rate, and fast Fourier transform size were adjusted. Then, these images were classified using ConvMixer architecture, similar to vision transformers (ViT) and multi-layer perceptron (MLP)-mixer structures, which have attracted a lot of attention. Its performance was compared with classical architectures such as ResNet18 and ResNet50. The results obtained showed that the ConvMixer structure gave very successful results and a very short operation time. Our proposed model has obtained an accuracy of 98.14%, 98.79%, and 97.69% for the ResNet18, ResNet50, and ConvMixer architectures, respectively. In addition, it has been observed that the processing time of the ConvMixer architecture is relatively short compared to these two architectures.
AtıfScopus21WoS16OpenAlex21İncele - Kitap BölümüYalnız künye2023An IT2FBWM Model to Highlight the Significance of Factors Utilized in Determining Pandemic Hospital Site Selection
Aycin, Ejder; Kayapinar Kaya, Sema; Ecer, Fatih
The COVID-19 pandemic has spread to the world in a short time since its emergence in Wuhan, China, and mobilized international health authorities with its effects, continues its development seriously. Due to the fast spread of COVID-19, governments have made some decisions to build new temporary hospitals for patients infected with COVID-19. This situation increased the importance of the site selection process for a pandemic hospital during the current critical time. Site selection of a hospital can be considered as multi-criteria decision-making (MCDM) problem since it includes multiple factors. This paper applies an analytical tool for evaluating the criteria of the site selection of a pandemic hospital. For this purpose, the extended best–worst method with trapezoidal interval type-2 fuzzy numbers (IT2FBWM) is employed to determine the importance weights of the pandemic hospital site selection criteria. The paper’s findings point out that the IT2FBWM model can help decision-makers determine the importance weights of the criteria used in the pandemic hospital siting decisions.
AtıfScopus1OpenAlex2İncele - MakaleAçık Erişim2023Scopus SJRQ4The Assessment of Health Risk from Heavy Metals with Water Indices for Irrigation and the Portability of Munzur Stream: A Case Study of the Ovaclk Area (Ramsar Site), Türkiye
Kutlu, Banu; Sarlgül, Ali
Surface water samples from the area of Munzur Stream in Türkiye (a Ramsar site) were evaluated for their suitability for irrigation and drinking purposes using different water quality indices. The human health risks were assessed as well. The study was conducted over a period of 24 months from January 2019 to December 2021 by taking samples from nine stations every month in order to determine the water quality of Munzur Stream, located in Tunceli. According to the results, Munzur Stream is in good condition in terms of the quality of drinking water and irrigation water. The concentrations of heavy metals such as Cu, Ni, Fe and Hg were high, though the water quality parameter according to Türkiye Ministry of Forestry and Water Affairs Surface Water Quality Regulations (TSWQR) was significantly lower than the permitted limits. In Munzur Stream, the irrigation water for all stations was reported to be excellent, good and suitable in terms of SAR, Na% and MH, respectively. The principal component analysis data formed the four principal components, explaining 98.22% of the total variance. The sources of pollution in this area include the rock types of the basin, soil erosion, domestic waste water discharge and agricultural flow of inorganic fertilisers.
AtıfWoS1OpenAlex3İncele - MakaleYalnız künye2023Scopus SJRQ2Analysis of awareness of gynaecological cancers İn women using social media
Alp Dal, Nursel; Gümüşsoy, Süreyya; Ertem, Gül
This study aimed to use social media to investigate the relationship between the demographic, obstetric and gynaecological characteristics and the awareness of gynaecological cancer among women. The data were collected between 1st March and May 2018 using an internet-baseline survey/surveymonkey/google form. The sample was consisted of 1227 women who were literate, active social media users and had volunteered to participate in the study via social media. The GCAS scores of women who were in the age range 20–24 years, primary school graduates, no social security, were not pregnant, had a miscarriage, did not examine their external genital organs, had not entered the menopause and who did not use any family planning methods, were lower than the other women. The GCA of the women was found to be high.
AtıfScopus3WoS2OpenAlex5İncele - MakaleYayıncıda açık erişim2023Scopus SJRQ4Family Physician’s Opinions and Recommendations on the Family Medicine Practices
Baş, Kazım
Objectives: This study aims to evaluate the opinions and recommendations of family physicians working in family health centers regarding the practices of family medicine. Methods: This descriptive research was conducted with 307 family physicians working in family health centers of Elazığ and Muş provinces located in the east of Turkey between September and November 2021. The sample of this study was comprised of 193 (62.9%) family physicians who were available during the study period. The questionnaire created by the researcher was used to collect with the face-to-face interview technique and/or Google Forms data. Results: A total of 193 family physicians were included in the study. The mean age of the family physicians was 41.4±8.5 years, and their mean population was 3138.1±534.1 people. Of the family physicians, 184 (95.3%) stated professional devaluation, 179 (92.7%) excessive workload, the problems arising from the legislation, 173 (89.6%) performance, 158 (81.9%) the excess of the population to be served, 155 (80.3%) financial problems, coordination problems with senior management, 132 (68.4%) inadequate with the physical structure of the building and equipment, and 125 (64.8%) stated the insufficient number of non-physician personnel were among the factors negatively affecting work in family health centers. In addition, 180 (93.2%) family physicians stated that changes are needed in existing family medicine practices. Conclusion: According to the study results, there are negative situations that affect the effective and efficient implementation of family medicine practices. The current policy needs to be revised to carry out family medicine practices effectively and efficiently.
AtıfScopus2OpenAlex2TR Dizin2
İncele - MakaleAçık Erişim2023Scopus SJRQ3The effect of different boron compounds on nutrient digestibility, intestinal nutrient transporters, and liver lipid metabolism
Şahin, Emre; Orhan, Cemal; Erten, Füsun; Şahin, Fikrettin; Şahin, Nurhan; Şahin, Kazim
Background/aim: Gastrointestinal health is essential for maintaining a healthy lifestyle. Improving nutrient absorption and energy metabolism are the critical targets for intestinal health. This study aimed to determine the effects of different boron (B) derivatives on nutrient digestibility, intestinal nutrient transporters, and lipid metabolism in rats. Materials and methods: Twenty-one rats were allocated to three groups (n = 7) as follows: (i) Control, (ii) Sodium pentaborate pentahy-drate (SPP), and (iii) boric acid (BA). The rats were fed a chow diet (AIN-93M) and supplemented with 8 mg/kg elemental B from SPP (45.2 mg/kg BW) and BA (42.7 mg/kg BW) via oral gavage every other day for 12 weeks. The nutrient digestibility of rats in each group was measured using the indigestible indicator (chromium oxide, Cr2 O3, 0.20%). At the end of the experiment, animals were decapitated by cervical dislocation and jejunum, and liver samples were taken from each animal. The nutrient transporters and lipid-regulated transcription factors were determined by RT-PCR. Results: The nutrient digestibility (except for ash) was increased by SPP and BA supplementation (p < 0.05). SPP and BA-supplemented rats had higher jejunal glucose transporter 1 (GLUT1), GLUT2, GLUT5, sodium-dependent glucose transporter 1 (SGLT1), fatty acid transport protein-1 (FATP1), and FATP4 mRNA expression levels compared to nonsupplemented rats (p < 0.0001). BA-supplemented rats had remarkably higher peroxisome proliferator-activated receptor gamma (PPARγ) levels than nonsupplemented rats (p < 0.0001). In contrast, sterol regulatory element-binding protein 1c (SREBP-1c), liver X receptor alpha (LxR-α), and fatty acid synthase (FAS) levels decreased by SPP supplementation compared to other groups (p < 0.05). Conclusion: SPP and BA administration enhanced nutrient digestibility, intestinal nutrient transporters, and liver lipid metabolism in rats.
AtıfScopus8WoS7OpenAlex9TR Dizin1İncele - MakaleAçık Erişim2023Scopus SJRQ2Expression of phoenixin-14 and nesfatin-1 in the hypothalamo–pituitary–gonadal axis in the phases of the estrous cycle
Parlak Ak, Tuba; Yaman, Mine; Bayrakdar, Ali; Bulmus, Ozgur
Phoenixin-14 (PNX-14) and nucleobindin 2 (NUCB2)/nesfatin-1 are regulatory neuropeptides expressed in the hypothalamus. These neuropeptides can be effective in hormonal regulation of the hypothalamo–pituitary–gonadal (HPG) axis and reproductive functions. In the present study, the distribution of PNX-14 and NUCB2/nesfatin-1 in the hypothalamus, pituitary, ovary, and uterus tissues during the phases of the estrous cycle in female rats was investigated. Eighteen Wistar Albino rats determined among animals showing regular estrous cycle by vaginal smear method were divided into three groups: proestrus (Group I), estrus (Group II) and diestrus (Group III). Serum gonadotropin-releasing hormone (GnRH), plasma PNX-14, and NUCB2/nesfatin-1 concentrations were the highest, moderate, and lowest in estrus, diestrus, and proestrus phases, respectively. PNX-14 immunoreactivity in the supraoptic and arcuate nuclei of the hypothalamus and NUCB2/nesfatin-1 immunoreactivity in the paraventricular nuclei were particularly evident in the estrus phase. These neuropeptide immunoreactivities were decreased in different cells of anterior pituitary during proestrus compared with those during estrus and diestrus. PNX-14 immunoreactivity in the ovary, especially during the estrus phase, was diffuse and intense in the granulosa and luteal cells and oocytes, and it was few and weak in theca cells. In addition, NUCB2/nesfatin-1 immunoreactivity was abundant and strong in granulosa and luteal cells, theca and interstitial cells, and oocytes during estrus. In the estrus phase, PNX-14 immunoreactivity was strong in the glandular epithelial cells and stromal cells of the endometrium, also NUCB2/nesfatin-1 immunoreactivity was strong in the epithelial and glandular epithelial cells. As a result, when the estrous cycle was evaluated, it was concluded that the changes in the distribution of PNX-14 and NUCB2/nesfatin-1 at all phases were related to GnRH and that these neuropeptides showed the highest immunoreactivity especially in the HPG axis and uterus tissues of estrus rats.
AtıfScopus21OpenAlex22İncele - MakaleYalnız künye2023Scopus SJRQ2A novel electrochemical sensor for metoprolol analysis based on glutardialdehyde–zinc oxide modified boron doped diamond electrode
Koçak, Berna; İpek, Yeliz; Keçeci, Ali
In this study, glutardialdehyde–zinc oxide modified boron doped diamond electrode (GA2–ZnO/BDDE) was developed as a new electrochemical sensor for the rapid, sensitive and selective determination of metoprolol (MTP). By using boron doped diamond electrode (BDDE), glutardialdehyde modified boron doped diamond electrode (GA2/BDDE) and glutardialdehyde–zinc oxide modified boron doped diamond electrode (GA2–ZnO/BDDE) separately, the electrochemical behavior of MTP on the surfaces of these electrodes was determined by applying cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. According to the results, the linear working range was 9.99 × 10−7–3.85 × 10−5 mol·L−1 and the limit of detection (LOD) was 7.53 × 10−8 mol·L−1 in pH 7 Britton–Robinson buffer solution. In addition, intraday reproducibility of peak current and peak potential were measured on the GA2–ZnO/BDDE surface and the results were calculated as 0.56 and 1 (RSD%), respectively. In order to investigate the reproducibility of GA2–ZnO/BDDE, 5 different modified electrodes were prepared with the same composition and conditions. The interday repeatability of the modified electrode was calculated as 3.13 (RSD%) and 1.05 (RSD%) for interday peak current and peak potential, respectively. The applicability of this method was confirmed by analysis of commercial drug tablets containing MTP as active ingredient. The mean recovery of the developed sensor was 95.6 % ± 1.7.
AtıfScopus14WoS12OpenAlex13İncele - MakaleAçık Erişim2023Scopus SJRQ1Effects of a Combination of Arginine Silicate Inositol Complex and a Novel Form of Biotin on Hair and Nail Growth in a Rodent Model
Demir, Betul; Cicek, Demet; Orhan, Cemal; Er, Besir; Erten, Fusun; Tuzcu, Mehmet; Ozercan, Ibrahim Hanifi; Sahin, Nurhan; Komorowski, James; Ojalvo, Sara Perez
The purpose of this study was to examine the effects of a combination of inositol-stabilized arginine silicate complex (ASI) and magnesium biotinate (MgB) on hair and nail growth in an animal model. Twenty-eight female Sprague–Dawley rats (8 weeks old) were randomized into one of the following groups: (i) group (control), shaved; (ii) group (ASI), shaved + ASI (4.14 mg/rat/day); (iii) group (ASI + MgB I), shaved + ASI (4.14 mg/rat/day) + MgB (48.7 μg/rat/day); and (iv) group (ASI + MgB II), shaved + ASI (4.14 mg/rat/day) + MgB (325 μg/rat/day). On day 42, compared with the control group, while hair density (p < 0.05, p < 0.01, and p < 0.0001, respectively) and anagen ratio (p < 0.01, p < 0.01, and p < 0.001) increased in the ASI, ASI + MgB I, and ASI + MgB II groups, telogen ratio decreased (p < 0.01, p < 0.01, and p < 0.001, respectively). In the molecular analysis, VEGF, HGF, and KGF-2 increased in the ASI (p < 0.01, p < 0.01, and p < 0.05, respectively), ASI + MgB I (p < 0.0001 for all), and ASI + MgB II (p < 0.0001 for all) groups when compared to the control group. FGF-2 (p < 0.01) and IGF-1 (p < 0.001) were found to be increased in the ASI + MgB I and ASI + MgB II groups. SIRT-1 and β-catenin increased in the ASI (p < 0.05 and p < 0.01), ASI + MgB I (p < 0.001 for both), and ASI + MgB II (p < 0.0001 for both) groups. Wnt-1 increased in the ASI + MgB I (p < 0.001) and ASI + MgB II (p < 0.0001) groups. In conclusion, the combination of ASI and MgB could promote hair growth by regulating IGF-1, FGF, KGF, HGF, VEGF, SIRT-1, Wnt, and β-catenin signal pathways. It was also established that ASI did not affect nail growth, whereas the MgB combination was effective using a higher dose of biotin.
AtıfScopus11WoS9OpenAlex11İncele - MakaleAçık Erişim2023Scopus SJRQ3Evaluation of the spiritual care needs of risky pregnants from the perspective of the patient and the clinician: A qualitative research
Yüksekol, Özlem Doğan; Ulucan, Mihriban; Baltacı, Nazlı; Nazik, Feyza
Objectives: Being diagnosed with a risky pregnancy and complications developing during pregnancy cause both stress and uncertainty for women and their families, so women with risky pregnancies need spiritual care more. For this reason, this research was conducted to determine the spiritual care needs of risky pregnant women which require a multidisciplinary approach. Methods: The research is a phenomenological descriptive type of qualitative research. The study was completed with 20 participants, including 10 pregnant women who were hospitalized in the obstetrics and gynecology clinic and diagnosed with risky pregnancy, and 10 clinicians who were responsible for the care and treatment of pregnant women in the clinic. Data were collected using a semi-structured interview form. Data analysis was supported by the MaxQda 2020 Pro package program. Results: The two themes that emerged in this study are the perspectives of pregnant women and the perspectives of clinicians. Each theme is categorized as spirituality and spiritual care perceptions, spiritual care needs and experiences, and barriers to spiritual care. Conclusion: According to the findings obtained from the study, it is seen that the views of pregnant women and clinicians on spiritual care are similar. Supportive relationships and providing respectful maternal care are among the spiritual care needs of women with risky pregnancies, and these help to maintain the spiritual well-being of pregnant women.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2023Scopus SJRQ1Evaluation of pea/rice and amylopectin/chromium as an alternative protein source to improve muscle protein synthesis in rats
Ozdemir, Oguzhan; Erten, Fusun; Er, Besir; Orhan, Cemal; Komorowski, James R.; Sylla, Sarah; Perez Ojalvo, Sara; Sahin, Kazim
Background: A preclinical study reported that the combination of an amylopectin/chromium complex (ACr) of branched-chain amino acids (BCAA) significantly enhanced muscle protein synthesis (MPS). This study was conducted to determine the effects of the addition of ACr complex to a pea/rice (PR) protein on MPS, insulin, muslin levels, and the mTOR pathway in exercised rats. Methods: Twenty-four rats were divided into three groups: (i) exercise (Ex); (ii) Ex + PR 1:1 blend (0.465 g/kg BW); (iii) Ex + PR + ACr (0.155 g/kg BW). On the day of single-dose administration, after the animals were exercised at 26/m/min for 2 h, the supplement was given by oral gavage. The rats were injected with a bolus dose (250 mg/kg BW, 25 g/L) of deuterium-labeled phenylalanine to determine the protein fractional synthesis rate (FSR) one h after consuming the study product. Results: The combination of PR and ACr enhanced MPS by 42.55% compared to the Ex group, while Ex + PR alone increased MPS by 30.2% over the Ex group (p < 0.0001) in exercised rats. Ex + PR plus ACr significantly enhanced phosphorylation of mTOR and S6K1 (p < 0.0001), and 4E-BP1 (p < 0.001) compared to the Ex (p < 0.0001). PR to ACr also significantly increased insulin and musclin levels (p < 0.0001) in exercised rats. Additionally, compared to Ex + PR alone, Ex + PR + ACr enhanced mTOR (p < 0.0001) and S6K1 (p < 0.0001) levels. Conclusion: These data suggested that PR + ACr may provide an alternative to animal proteins for remodeling and repairing muscle by stimulating MPS and mTOR signaling pathways in post-exercised rats. More preclinical and clinical human studies on combining pea/rice and amylopectin/chromium complex are required.
AtıfScopus4OpenAlex4İncele - MakaleAçık Erişim2023Scopus SJRQ2Unraveling the chemical profile, antioxidant, enzyme inhibitory, cytotoxic potential of different extracts from Astragalus caraganae
Kurt-Celep, İnci; Zengin, Gokhan; Uba, Abdullahi I.; Caprioli, Giovanni; Mustafa, Ahmed M.; Angeloni, Simone; Cakilcioglu, Ugur; Guler, Osman; Kaplan, Alevcan; Sharmeen, Jugreet
Six extracts (water, ethanol, ethanol-water, ethyl acetate, dichloromethane, and n-hexane) of Astragalus caraganae were studied for their biological activities and bioactive contents. Based on high-performance liquid chromatography-mass spectrometry (HPLC-MS), the ethanol-water extract yielded the highest total bioactive content (4242.90 µg g−1), followed by the ethanol and water extracts (3721.24 and 3661.37 µg g−1, respectively), while the least total bioactive content was yielded by the hexane extract, followed by the dichloromethane and ethyl acetate extracts (47.44, 274.68, and 688.89 µg g−1, respectively). Rutin, p-coumaric, chlorogenic, isoquercitrin, and delphindin-3,5-diglucoside were among the major components. Unlike the dichloromethane extracts, all the other extracts showed radical scavenging ability in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay (8.73–52.11 mg Trolox equivalent [TE]/g), while all extracts displayed scavenging property in the 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging assay (16.18–282.74 mg TE/g). The extracts showed antiacetylcholinesterase (1.27–2.73 mg galantamine equivalent [GALAE]/g), antibutyrylcholinesterase (0.20–5.57 mg GALAE/g) and antityrosinase (9.37–63.56 mg kojic acid equivalent [KAE]/g) effects. The molecular mechanism of the H2O2-induced oxidative stress pathway was aimed to be elucidated by applying ethanol, ethanol/water and water extracts at 200 µg/mL concentration to human dermal cells (HDFs). A. caraganae in HDF cells had neither a cytotoxic nor genotoxic effect but could have a cytostatic effect in increasing concentrations. The findings have allowed a better insight into the pharmacological potential of the plant, with respect to their chemical entities and bioactive contents, as well as extraction solvents and their polarity.
AtıfScopus31OpenAlex36İncele - MakaleAçık Erişim2023Investigation of the Level of Attachment of Fathers to the Fetus and Factors Affecting Such Attachment in the Prenatal Period; [Prenatal Dönemde Babaların Fetüse Bağlanma Düzeyi ve Bu Bağlanmayı Etkileyen Faktörler]
Gümüşsoy, Süreyya; Dönmez, Sevgül; Alp Dal, Nursel
Objective: The aim of this study was to determine the level of attachment of fathers to the fetus and the factors affecting such attachment in the prenatal period. Methods: This descriptive study was conducted on 463 fathers whose spouses were 24–38 weeks pregnant in the obstetrics outpatient clinic of the University Research and Practice Hospital Gynecology Department between December 2019 and April 2020. The “Information Form” and “Intrauterine Father Attachment Scale” (IFAS) were used as data collection tools for this study. Results: In this study, the total score of Intrauterine Father Attachment Scale was found to be 62.22 ± 10.66 (min = 34, max = 87). The mean Intrauterine Father Attachment Scale scores of the fathers who had a good income level had a less marriage period, had less children, had a high educational level, who want to have more children, and whose spouse’s pregnancy was not risky were found to be higher than those of the fathers who did not (p >.05). Furthermore, of the fathers those who were previously knowledgeable about baby care and were experienced in baby care thought that both of the parents should be responsible for the care of the baby, perceived the support given by his family as sufficient, thought that marriage means happiness, wanted to attend their wives’ childbirth in the delivery room, wanted to attend pregnancy schools, and thought that the social relations affect the baby positively obtained higher scores from the IFAS (p >.05). Conclusion: Regression results have shown that getting information about baby care, who is mostly responsible for a baby’s care, educational status, and status of wanting to join pregnant schools have a significant impact on Intrauterine Father Attachment Scale scores.
AtıfScopus5OpenAlex3TR Dizin2İncele - MakaleYalnız künye2023Scopus SJRQ2Chemical Characterization of Different Extracts from Artemisia annua and Their Antioxidant, Enzyme Inhibitory and Anti-Inflammatory Properties
Acquaviva, Alessandra; Nilofar; Bouyahya, Abdelhakim; Zengin, Gokhan; Di Simone, Simonetta Cristina; Recinella, Lucia; Leone, Sheila; Brunetti, Luigi; Uba, Abdullahi Ibrahim; Cakilcioğlu, Ugur
Artemisia annua L. (Asteraceae Family) is an important plant in Asia that has been used for treating different diseases, including fever due to malaria, wounds, tubercolisis, scabues, pain, convulsions, diabetes, and inflammation. In this study we aimed to evaluate the effects of different polarity extracts (hexane, dichloromethane, ethyl acetate, ethanol, ethanol/water (70 %) and water) from A. annua against the burden of inflammation and oxidative stress occurring in colon tissue exposed to LPS. In parallel, chemical composition, antiradical, and enzyme inhibition effects against α-amylase, α-glucosidase, tyrosinase, and cholinesterases were evaluated. The water extract contained the highest content of the total phenolic with 34.59 mg gallic acid equivalent (GAE)/g extract, while the hexane had the highest content of the total flavonoid (20.06 mg rutin equivalent (RE)/g extract). In antioxidant assays, the polar extracts (ethanol, ethanol/water and water) exhibited stronger radical scavenging and reducing power abilities when compared to non-polar extracts. The hexane extract showed the best AChE, tyrosinase and glucosidase inhibitory effects. All extracts revealed effective anti-inflammatory agents, as demonstrated by the blunting effects on COX-2 and TNFα gene expression. These effects seemed to be not related to the only phenolic content. However, it is worthy of interest to highlight how the higher potency against LPS-induced gene expression was shown by the water extract; thus suggesting a potential phytotherapy application in the management of clinical symptoms related to inflammatory colon diseases, although future in vivo studies are needed to confirm such in vitro and ex vivo observations.
AtıfScopus45OpenAlex43İncele - MakaleAçık Erişim2023Scopus SJRQ1Body appreciation around the world: Measurement invariance of the Body Appreciation Scale-2 (BAS-2) across 65 nations, 40 languages, gender identities, and age
Swami, Viren; Tran, Ulrich S.; Stieger, Stefan; Aavik, Toivo; Ranjbar, Hamed Abdollahpour; Adebayo, Sulaiman Olanrewaju; Afhami, Reza; Ahmed, Oli; Aimé, Annie; Akel, Marwan
The Body Appreciation Scale-2 (BAS-2) is a widely used measure of a core facet of the positive body image construct. However, extant research concerning measurement invariance of the BAS-2 across a large number of nations remains limited. Here, we utilised the Body Image in Nature (BINS) dataset – with data collected between 2020 and 2022 – to assess measurement invariance of the BAS-2 across 65 nations, 40 languages, gender identities, and age groups. Multi-group confirmatory factor analysis indicated that full scalar invariance was upheld across all nations, languages, gender identities, and age groups, suggesting that the unidimensional BAS-2 model has widespread applicability. There were large differences across nations and languages in latent body appreciation, while differences across gender identities and age groups were negligible-to-small. Additionally, greater body appreciation was significantly associated with higher life satisfaction, being single (versus being married or in a committed relationship), and greater rurality (versus urbanicity). Across a subset of nations where nation-level data were available, greater body appreciation was also significantly associated with greater cultural distance from the United States and greater relative income inequality. These findings suggest that the BAS-2 likely captures a near-universal conceptualisation of the body appreciation construct, which should facilitate further cross-cultural research.
AtıfScopus108OpenAlex109İncele - MakaleAçık Erişim2023Scopus SJRQ1The effect of oral administration of undenatured type II collagen on monosodium iodoacetate-induced osteoarthritis in young and old rats
Sahin, Emre; Orhan, Cemal; Erten, Fusun; Saiyed, Zainulabedin; Azari, Elnaz Karimian; Durkee, Shane; Sahin, Kazim
We investigated whether different doses of undenatured type II collagen (undenatured collagen, UC-II) help improve monosodium iodoacetate (MIA)-induced (osteoarthritis) OA in young and old rats. A total of 70 rats were divided into five groups: (1) control; (2) MIA (a single intra-articular injection of MIA); (3)–(5) MIA+ Undenatured Collagen with various oral doses (0.66, 1.33, and 2 mg/kg). The results showed that all doses of undenatured collagen in both age groups reduced knee diameter, while the two higher doses (1.33 mg/kg and 2 mg/kg) reduced the Mankin score and increased most gait measurements as early as day 14 compared to the MIA rats. However, the 2 mg/kg dose showed the best efficacy in improving Mankin score and gait measurements by 28 days post-OA induction. In young but not old rats, all doses of undenatured collagen reduced the Kellgren-Lawrence score compared to the MIA group. Undenatured collagen reduced the levels of most inflammatory and cartilage breakdown markers in serum and knee joint cartilage in both age groups. In conclusion, this data suggests that while all doses of undenatured collagen supplementation may ameliorate MIA-induced OA symptoms, the higher doses showed faster improvement in gait measurements and were more efficacious for overall joint health in rats.
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