Yazarlar
- Gul, Muhammet(35)
- Erten, Fusun(23)
- Zengin, Gokhan(23)
- Benzer, Fulya(22)
- Dal, Nursel Alp(20)
- Sahin, Kazim(20)
- Orhan, Cemal(19)
- Yeşiltepe, Akgün(17)
- Topal, Murat(15)
- Yucesan, Melih(15)
- Yildirim, Ozal(13)
- Öbek, Erdal(13)
- Aksakal, B.(12)
- Gürarslan Baş, Nazan(12)
- Alp Dal, Nursel(11)
- Baloglu, Ulas Baran(11)
- Cakilcioglu, Ugur(11)
- Kandemir, Fatih Mehmet(11)
- Paksoy, Mehmet Yavuz(11)
- Talo, Muhammed(11)
- Celik, Erkan(10)
- Er, Besir(10)
- Say, Yakup(10)
- Yaman, Mine(10)
- Yüksekol, Özlem Doğan(10)
- Aksu, Önder(9)
- Aslan, N.(9)
- Aslan, Naim(9)
- Baş, Kazım(9)
- Erişir, Mine(9)
- Mahomoodally, Mohamad Fawzi(9)
- Acharya, U. Rajendra(8)
- Caprioli, Giovanni(8)
- Karatay, Gülnaz(8)
- Kocabaş, Mehmet(8)
- Macit, Arife(8)
- Parlak Ak, Tuba(8)
- İpek, Yeliz(8)
- Beydağ, Kerime Derya(7)
- Camas, Mustafa(7)
Yayınlar
- MakaleAçık Erişim2022Klinik Uygulamanın Hemşirelik Öğrencilerinin Problem Çözme ve Karar Verme Becerilerine Etkisi: Yarı Deneysel Çalışma
Şeker, Sevda Arslan; Erkus Kucukkelepce, Gulhan
Amaç: Bu araştırmada, klinik uygulamanın hemşirelik son sınıf öğrencilerinin problem çözme ve karar verme becerilerine etkisinin belirlenmesi amaçlanmıştır. Gereç ve Yöntemler: Kontrol grupsuz öntest ve son-test yarı deneysel türde yapılan bu araştırmanın örneklemini 77 öğrenci oluşturmuştur. Veriler, Tanıtıcı Özellikler Formu, Problem Çözme Envanteri (PÇE) ve Hemşirelikte Klinik Karar Verme Ölçeği (HKKVÖ) kullanılarak toplanmıştır. Verilerin analizinde tanımlayıcı istatistikler, bağımsız örneklem t-testi, bağımlı örneklem t-testi kullanılmıştır. Bulgular: Öğrencilerin ön-test PÇE puan ortalaması 85,97±18,29 iken son-test puan ortalaması 93,01±18,40’tır. HKKVÖ ön-test puan ortalaması 97,82±16,64 iken son-test puan ortalaması 138,14±15,13’tür. Öğrencilerin, ön-test ve son-test PÇE toplam, Düşünen yaklaşım, Kendine güvenli yaklaşım, Planlı yaklaşım alt boyut puan ortalamaları ile HKKVÖ ve alt boyutları arasında istatistiksel olarak anlamlı farklılık saptanmıştır (p<0,05). Yaş, cinsiyet, akademik ortalama değişkenlerine göre PÇE ve HKKVÖ toplam puan ortalamaları istatistiksel olarak anlamlı farklılık göstermemiştir (p>0,05). Sonuç: Hemşirelik öğrencilerinin problem çözme ve karar verme becerileri orta düzeydedir. Öğrencilerin problem çözme ve karar verme ile ilgili ders/kurs alma durumlarının son-testte problem çözme beceri algılarını azalttığı, erkek öğrencilerin ön-test Sonuçları değerlendirmek alt boyutu puan ortalamalarının kadın öğrencilerden anlamlı derecede daha fazla olduğu bulunmuştur. Problem çözme ve karar verme becerilerinin geliştirilmesinde klinik öğretim sürecine farklı öğretim yöntemlerinin eklenmesi önerilmektedir.
AtıfOpenAlex2TR Dizin1
İncele - MakaleAçık Erişim2022Immunomodulation function of Tunceli garlic (Allium tuncelianum) oil in Rainbow Trout (Oncorhynchus mykiss)
Ispır, Ünal; Özcan, Mikail; Şeker, Engin
The effects of injectable Tunceli garlic oil (Allium tuncelianum) on serum response of rainbow trout were examined. Influence of intraperitoneal (i.p.) injection administration of Tunceli garlic oil (TGO) was evaluated on some immunological factors of rainbow trout. Fish weight 40 g were i.p. injected TGO at doses of 1% and 10%. Serum lysozyme activity, bactericidal activity, myeloperoxidase, protein and immunoglobulin levels were measured on days 3, 7, 14 and 21 after the TGO administration. All the immune parameters assayed remained affected when TGO was i.p. administered. Serum bactericidal activity was consistently achieved by immunizing fish with TGO. Levels of serum myeloperoxidase activity were increased in the groups of fish injected with TGO. Myeloperoxidase and bactericidal activities peaked at 14 and 21 days post-injection, respectively. Lysozyme activity was significantly increased throughout experiment in the all groups. Total protein and immunoglobulin levels increased in the 21 days post-injection although no statistically significant differences. In conclusion, these results suggest that there are functionally effects of TGO on the immune mechanisms of rainbow trout.
AtıfOpenAlex2TR Dizin1İncele - MakaleAçık Erişim2022The relationship between perceived social support during pregnancy and postpartum comfort
Dal, Nursel Alp; Yetişmiş, Habibe Yaşar
This study was carried out to examine the relationship between perceived social support during pregnancy and postpartum comfort. The data for the cross-sectional study were collected from 544 puerperal women through face-to-face interview between 15.11.2019 and 15.03.2020, using a personal introduction form containing individual information, the Multidimensional Perceived Social Support Scale (MSPSS), and the Postpartum Comfort Questionnaire (PPCQ). Pearson correlation analysis and simple linear regression analysis were used together with descriptive statistics for statistical analysis. Results: 37.5% of the puerperal participants in the study were over 30 years old and 52% had more than three pregnancies. In our study, it was found that there was a positive significant correlation between the total MSPSAS and PPCQ total scores of the puerperal women (r = 0.140). As a result of the study, it was found that as the level of social support perceived by the puerperant during pregnancy increased, the postpartum comfort level increased. Midwives, who are an important part of social support, should determine the support level of pregnant women during pregnancy and birth, postpartum period, and provide support and information to women on all kinds of issues that will increase the comfort of women, such as education and counseling.
AtıfOpenAlex8TR Dizin5İncele - MakaleAçık Erişim2022Dijital medya çağında sosyal röntgencilik: ınstagram örneği
Hayir, Celal; Karahisar, Tüba
Yaşadığımız bu dönemde yoğunluklu olarak kullandığımız sosyal medya platformları günlük yaşam pratikleri içinde birer zorunlu ihtiyaca dönüşmüştür. İnternet kullanabilen her bireyin mutlaka (en az bir) sosyal medya hesabı bulunmaktadır. İnsanlar artık çeşitli konulardaki ihtiyaçlarına cevabı bu mecralarda aramaktadır. Tanıdık ya da tanımadık insanlar hakkında tutum, davranış ve yargılar, sosyal medya hesapları yakın takibe alınarak oluşmaktadır. Instagram bu bağlamda ele alınıp incelenmesi gereken en önemli sosyal mecradır. Bugün dünya genelinde 1 milyardan fazla, ülkemizde ise 39 milyon Instagram kullanıcısı bulunmaktadır. Türkiye, dünyada en çok Instagram kullanan ülkeler arasında altıncı sırada yer almaktadır. İstatistiki veriler ülkemizde oldukça yoğun bir şekilde Instagram kullanıldığını göstermektedir. Çalışmanın amacı; ülkemizde 18 yaş üstü bireylerin hangi amaçla Instagram kullandığını, Instagram’da paylaşımda bulunup bulunmadığı, takip ettiği kişilerin paylaşımlarına hangi saiklerle sürekli bakma gereği duyduğunu “sosyal röntgencilik” kavramı bağlamında araştırmaktır. Buna bağlı olarak Instagram kullanıcılarını sosyal röntgenciliğe iten davranışın ardındaki nedenler ankette yer alacak sorular ile tespit edilmeye çalışılmıştır. Çalışmada, demografik özelliklere yönelik beş, Instagram kullanım ve paylaşım nedenlerine ilişkin çoktan seçmeli altı, sosyal röntgencilik davranışına ilişkin beşli Likert tipte dokuz olmak üzere toplam 20 soru ve ifadeli anket formu oluşturulmuş ve 259 kişiye uygulanmıştır. Çalışma, anket formu ile toplanan veriler ile sınırlandırılmıştır ve anket verileri SPSS 26.0 programı ile analiz edilmiştir.
AtıfOpenAlex3TR Dizin1İncele - MakaleAçık Erişim2022Do healthy lifestyle behaviors affect COVID-19 vaccination attitudes in Generation Z?
Barut, Sümeyye; Baransel, Esra Sabancı; Can, Aylin
This study was carried out to determine the effects of healthy lifestyle behaviors on the COVID-19 vaccine attitude in the Z generation. The descriptive cross-sectional\rstudy was conducted in Turkey using web-based questionnaires, and 510 participants (348 women, 162 men, age 15-24) in the Z generation. The data were collected\rby using Personal Information Form and Health Lifestyle Behaviors Scale-II (HLBS-II). It was determined that 89.4% of the female participants and 85.8% of the male\rparticipants, who participated in the study, had the COVID-19 vaccine. It was determined that 84.2% of the women who had the COVID-19 vaccine received the second\rdose, while 76.3% of the men had the second dose. It was determined that the mean scores of women and men who had COVID-19 vaccine, found the COVID-19 vaccines\rsafe, and believed that it was more beneficial than harm, had higher mean scores from HLBS-II and the difference between the groups was statistically significant (p<0.05).\rAs a result of this study, it was determined that the healthy lifestyle behavior levels of the Z generation have an effective role on the COVID-19 vaccine attitudes during\rthe COVID-19 pandemic process.
AtıfOpenAlex7TR Dizin1İncele - BildiriYalnız künye2022Machine Learning-Based A Comparative Analysis for Air Quality Prediction
Utku, Anil; Can, Umit
Air pollution affects human life negatively, especially in terms of health, and causes the death of millions of people every year. Today, air pollution in many regions is still above the limits indicated by the World Health Organization. In this study, the prediction of the rate of PM2.5, which is an important air pollutant, in the Beijing region of China is emphasized. For this purpose, weather prediction models were created using Random Forest Algorithm, Support Vector Regression, XGBoost and K-Nearest Neighbor Algorithm, which are popular machine learning algorithms, and the results were compared using various metrics. The best prediction result in all the metrics used was obtained with the Support Vector Regression method.
AtıfWoS2OpenAlex8
İncele - MakaleAçık Erişim2022Scopus SJRQ3The Effectiveness Of Trigger Point Treatment In Chronic Pelvic Pain; A Pilot Randomised Controlled Trial; [Wirksamkeit der Triggerpunkt-Therapie bei chronischen Unterbauchschmerzen – eine randomisierte kontrollierte Pilotstudie]
Atas, Kubra; Mutlu, Ebru Kaya; Yasa, Cenk; Ugurlucan, Funda Gungor
Objective To investigate the effectiveness of ischemic compression and low-level laser therapy methods combined with exercise on the myofascial trigger points in women with Chronic Pelvic Pain and to determine which method is more effective. Methods It was a parallel designed, single-blind pilot randomized clinical trial. Patients were recruited at physiotherapy laboratory of the Istanbul University from September 2017 to June 2019. Twenty-eight women patients with Chronic Pelvic Pain were included into the trial. Patients were randomized into two groups. Group 1 received ischemic compression and Group 2 received low-level laser therapy twice a week for 6 weeks. Both groups received the same standard exercise program. Pain, range of motion, pelvic floor symptom severity, quality of life, satisfaction, anxiety, and depression were assessed after 6 weeks, and 1-year follow up. Results Following the treatment, significant differences were observed within both group subjects in pain, range of motion, symptom severity, quality of life, and anxiety-depression (p < 0.05). This significant improvement in pain, symptom severity, symptoms related quality of life and pain subgroup of Short Form 36, continued after 1-year follow up (p < 0.05). In comparison between group, Group 1 have more significant improvement than Group 2 in terms of symptoms related quality of life (p < 0.05). Conclusion Both methods have shown efficacy and can be used safely in chronic pelvic pain patients. Because it is more effective on symptoms related quality of life, the ıschemic compression method may be preferred for primary use.
AtıfScopus1WoS1OpenAlex2
İncele - MakaleAçık Erişim2022Scopus SJRQ2Effect of chlorpyrifos on some biochemical changes in Cyprinus carpio: the protective effect of ellagic acid
Mişe Yonar, Serpil; Yonar, Muhammet Enis; Ural, Mevlüt Şener; Pala, Ayşegül
In this study, ameliorative effects of ellagic acid (EA) on oxidative stress induced by chlorpyrifos (CPF) in carp, Cyprinus carpio, were investigated. Fish were divided into six groups: C (no treatment), EA (100 mg kg fish−1), CPF-1 (0.040 mg L−1), CPF-2 (0.080 mg L−1), CPF-1 + EA, and CPF-2 + EA. CPF and EA were applied simultaneously for 14 days and, at the end of the study, liver, kidney, and gill samples were collected from fish. On the taken tissue samples, malondialdehyde (MDA) level and some antioxidant enzyme (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione-S-transferase (GST)) activities were evaluated. The results demonstrated statistically significant increases in the MDA levels of the CPF-1 and CPF-2 groups. On the other hand, the MDA levels were significantly decreased by EA administration. Also, CPF exposure caused statistically significant increases in the SOD and GST activities and statistically significant decreases in the CAT and GPx activities. However, treatment with EA reversed negative alterations in the SOD, CAT, GPx, and GST activities. Therefore, the results of this study results showed that simultaneous treatment with EA alleviates CPF-induced oxidative stress in fish.
AtıfScopus8WoS10OpenAlex10
İncele - MakaleAçık Erişim2022Scopus SJRQ1Graphene reinforced hybrid-bioceramic coatings on porous-Ti6Al4V for biomedical applications: morphology, corrosion resistance, and cell viability
Aslan, N.; Aksakal, B.; Dikici, B.; Sinirlioglu, Z.A.
The effect of Hydroxyapatite (HA)-based coatings reinforced with reduced graphene oxide (rGO) on porous-Ti6Al4V (P-Ti6Al4V) alloys in terms of electrochemical corrosion and cell viability for potential biomedical applications was investigated in this study. The scaffold-porous surfaces of P-Ti6Al4V were coated by the biocomposite structure of HA and reduced graphene oxide (rGO) at various porosity rates (40, 50, and 60%) by using the sol–gel dip-coating method. The results of 0.5, 1.0, and 1.5 wt% rGO-HA coatings were compared to coatings that contained only HA (free-rGO). Raman spectroscopy, X-ray diffractometer, and scanning electron microscopy were used for structural and morphological characterizations. The coatings in vitro corrosion susceptibilities were tested in simulated body fluid at 37 °C. Compared to free-rGO coatings, the results showed that rGO reinforcements phases reduced the corrosion rate of the scaffolds. The corrosion rate increased as the porosity content of the scaffolds increased. In vitro cell viability tests revealed that samples of 0.5 and 1.0 wt% rGO-HA coating groups performed better than the control and 1.5 wt% rGO-HA samples. Graphical abstract: [Figure not available: see fulltext.]
AtıfScopus8WoS7OpenAlex6İncele - MakaleAçık Erişim2022Scopus SJRQ2Assessment of heavy metal accumulations and health risk potentials in tomatoes grown in the discharge area of a municipal wastewater treatment plant
Arslan Topal, E. Işıl; Topal, Murat; Öbek, Erdal
Some heavy metals were detected in organs of the tomatoes grown in the discharge area of effluents of a municipal wastewater treatment plant. Also, the health risk potentials of heavy metals in the tomatoes consumed by human were investigated. The highest concentrations for Cu, Ni, Cr, Mn and Pb were followed the order of root>leaf>stem>fruit. When the bioconcentration factors values calculated for bioconcentration of metals from effluent to stem and root were examined, the highest values were determined for Cu. When translocation factors values are examined, the highest translocation from root to leaf was determined for Cd. The highest translocation from stem to leaf was determined for Pb. The estimated total exposure dose for male, female and children was listed as Zn>Mn>Cu>Cr>Ni>Pb>Cd. In terms of dietary, we can list the non-carcinogenic risks of heavy metals as children> female> male. The highest carcinogenic risk was calculated for Cr via dietary intake.
AtıfScopus17WoS18OpenAlex20İncele - MakaleAçık Erişim2022Scopus SJRQ1Preliminary assessment of health risks associated with consumption of grapevines contaminated with mining effluents in Turkey: Persistent trace elements and critical raw materials
Topal, Murat; Arslan Topal, E.Işıl; Öbek, Erdal
In this study, some persistent trace elements and critical raw materials were investigated in grapevines contaminated with Pb–Zn mining effluents. The persistent trace elements under certain conditions remain without any change in form in the environment over long periods. The critical raw materials are the ones that have economic importance and have the risks associated with their supply. The health risks of persistent trace elements and critical raw materials in the leaves of grapevine that are consumed by humans were determined. The highest persistent trace elements concentrations followed the order of root > stem > leaf for Mn, Cu, Cd, Ni, and Cr while root > leaf > stem for Zn and leaf > root > stem for Pb. The maximum critical raw material concentrations for Co and V followed the order of root > stem > leaf. For Sb and La, these were leaf > root > stem and root > stem > leaf, respectively. The maximum critical raw materials concentrations for W was leaf > stem = root. The total maximum carcinogenic value was 0.146 for Cd while the total minimum carcinogenic value was 0.0054 for Pb. In this study, potential carcinogenic risk values in terms of ingestion of contaminated soil (Cr, Cd, and Ni) and dietary take of grapevine leaves (Ni, Cr, Cd, and Pb) are higher than acceptable levels (1 × 10−4 – 1 × 10−6). Maximum cancer risk on human health was determined as dietary intake of grapevine leaves. When hazard quotient for dietary (HQdie), hazard quotient for ingestion (HQing), and hazard quotient for inhalation (HQinh) values of critical raw materials were examined, the maximum values were observed for children. Also, the highest hazard quotient for dermal (HQder) value was determined for men. The hazard index and total hazard index values were >1 for critical raw materials. As a result, values >1 indicated potential non-carcinogenic human health risk associated with the consumption of grapevines contaminated with mining effluents. Actual region-specific exposure estimates for consumption of grapevines, however, were not evaluated. Integr Environ Assess Manag 2022;18:517–527.
AtıfScopus2WoS2OpenAlex3İncele - MakaleAçık Erişim2022Scopus SJRQ2A New Hybrid Fuzzy Multi-Criteria Decision Methodology for Prioritizing the Antivirus Mask over COVID-19 Pandemic
Kaya, Sema Kayapinar; Pamucar, Dragan; Aycin, Ejder
During the COVID-19 pandemic, masks have become essential items for all people to protect themselves from the virus. Because of considering multiple factors when selecting an antivirus mask, the decision-making process has become more complicated. This paper proposes an integrated approach that uses F-BWM-RAFSI methods for antivirus mask selection process with respect to the COVID-19 pandemic. Finally, sensitivity analysis was demonstrated by evaluating the effects of changing the weight coefficients of the criterion on the ranking results, simulating changes in Heronian operator parameters, and comparing the obtained solution to other MCDM approaches to ensure its robustness.
AtıfScopus21WoS15OpenAlex23İncele - MakaleAçık Erişim2022Job Satisfaction, Intent to Stay at Work, and Burnout Levels of Nurses Working in Coronavirus Disease 2019 Clinics: A Cross-Sectional Study
Erkuş Küçükkelepçe, Gülhan; Arslan Şeker, Sevda; Karaca, Türkan
Objective: It is thought that the fact that coronavirus disease 2019 pandemic process has been continuing for a long time, and the level of job satisfaction of nurses may have an impact on their intention to experience burnout and stay at work. This study aimed to determine the relationship between job satisfaction, intention to stay, and burnout levels of nurses working in coronavirus disease 2019 clinics. Methods: This descriptive and correlational study was conducted with 325 nurses who were working in coronavirus disease 2019 clinics. Data were collected using the sociodemographic characteristics form, the Minnesota Satisfaction Questionnaire, the Maslach Burnout Inventory, and the Intent to Leave Job Scale. Descriptive statistics, correlation analysis, and regression analysis were used in the analysis of the research data. Results: Emotional exhaustion, depersonalization, personal achievement, and intent to leave explain 45% of job satisfaction (F = 67.911, p =.000); job satisfaction and intent to leave explain 40% of emotional exhaustion (F = 111.470, p =.000), 16% of depersonalization (F = 33.785, p =.000), and 20% of personal achievement (F = 43.102, p =.000); job satisfaction, emotional exhaustion, depersonalization, and personal achievement explain 24% of intent to leave (F = 27.190, p =.000). Conclusion: The prolongation of the coronavirus disease 2019 pandemic, the uncertainty of the process, and the conditions related to the working environment of the nurses have an effect on job satisfaction, burnout, and intent to leave. The continuity of the well-being of employees is an important issue that needs to be emphasized and evaluated, as it will have a multi-faceted effect to be ready for different pandemics in the near/far future.
AtıfScopus1WoS1İncele - MakaleYalnız künye2022Scopus SJRQ2Integrated electron beam irradiation treatment with hydrogen peroxide aqueous solution to inactivate Salmonella on grape tomatoes
Omac, Basri; Moreira, Rosana G.; Castell-Perez, Elena M.
This study investigated the efficacy of integrated electron beam (e-beam) irradiation and hydrogen peroxide (H2O2) aqueous solution treatments to inactivate mixed strains of Salmonella inoculated in grape tomatoes. Whole grape tomatoes were inoculated with a mixed bacterial cocktail composed of five strains of Salmonella enterica corresponding to serotypes Rissen (SAL1449), Montevideo (SAL4599), Saintpaul (476398), and Typhimurium (ATCC 13311 and ATCC 700720), dried in a biological safety cabinet for 2 h at room temperature and then stored at 4°C for 24 h to facilitate bacterial attachment before treatment. Tomatoes in H2O2 (60 mg/L) aqueous solution were irradiated at 0.45, 0.60, 0.75, 1.0, and 1.25 kGy dose. The combined treatment of 1.0 kGy radiation dose and 60 mg/L H2O2 achieved 4-log reductions in Salmonella. The D10−average value of Salmonella in the present study was 0.25 ± 0.01 kGy. Regarding the effect of the treatment on tomato quality, the combined application of e-beam up to 1.25 kGy and H2O2 (60 mg/L) did not affect (p >.05) the color and texture of grape tomatoes compared to non-irradiated samples. Furthermore, the combined treatments of e-beam and H2O2 aqueous solution reduced the dose uniformity ratio (DUR) by 7%, a relevant finding regarding commercial applications of electron beam accelerators. Exposure of the tomatoes to e-beam and water wash with added H2O2 is a promising decontamination system for use in tomatoes and other produce processing. Further studies on the optimization of this integrated treatment are needed. Practical Applications: Electron beam irradiation of tomatoes immersed in hydrogen peroxide (H2O2) solution reduces the dose required to eliminate pathogens in the fresh produce. The integrated treatment ensures minimal changes to produce quality and increased treatment efficiency in terms of dose uniformity.
AtıfScopus5WoS5OpenAlex4İncele - MakaleAçık Erişim2022Scopus SJRQ1A Bayesian BWM and VIKOR-based model for assessing hospital preparedness in the face of disasters
Saner, Halit Serdar; Yucesan, Melih; Gul, Muhammet
Hospitals are the first point of contact for people in the face of disasters that interfere with the daily functioning of life and endanger health and social life. All preparations should be made considering the worst possible conditions and the provided service should continue without interruption. In this study, a multi-criteria decision-making model was developed to evaluate disaster preparedness of hospitals. This decision model includes Bayesian best–worst method (BBWM), the VlseKriterijumska Optimizacija I Kompromisno Resenje (VIKOR) and technique for order preference by similarity to ideal solution (TOPSIS) methods. With the proposed decision model, six main criteria and 34 sub-criteria related to disaster preparedness of hospitals were considered. The criteria and sub-criteria evaluated in pairwise comparison manner by the experts were weighted with BBWM. These weight values and the data obtained from the six Turkish hospitals were combined to provide inputs for VIKOR and TOPSIS. In addition, a comparative study and sensitivity analysis were carried out using weight vectors obtained by different tools. BBWM application results show that the “Personnel” criterion was determined as the most important criterion with an importance value of 26%. This criterion is followed by “Equipment” with 25%, “Transportation” with 14%, “Hospital building” and “Communication” with 12%, and “Flexibility” with 11%. Hospital-2 was determined as the most prepared hospital for disasters as a result of VIKOR application. The VIKOR Q value of this hospital was obtained as 0.000. According to the results of the comparative study, Hospital-2 was determined as the most disaster-ready hospital in all six different scenarios. This hospital is followed by Hospital-4 (Q = 0.5661) and Hospital-5 (Q = 0.7464). The remaining rankings were Hospital-6, Hospital-3 and Hospital-1. The solidity of the results was checked with TOPSIS. Based on TOPSIS application results, Hospital-2 was again found the most-ready hospital. The usage of BBWM in this study enabled the expert group’s views to be combined without loss of information and to determine the criteria and sub-criteria weights with less pairwise comparisons in a probabilistic perspective. Via the “Credal ranking”, which is the contribution of BBWM to the literature, the interpretation of the hierarchy between each criterion has been performed more precisely.
AtıfScopus48WoS37OpenAlex51İncele - MakaleAçık Erişim2022Scopus SJRQ2Chrysin and flunixin meglumine mitigate overloaded copper-induced testicular and spermatological damages via modulation of oxidative stress and apoptosis in rats
Parlak Ak, Tuba; Tatli Seven, Pinar; Gur, Seyfettin; Gul, Burcu; Yaman, Mine; Seven, Ismail
This study aimed to evaluate the possible protective actions of chrysin and flunixine meglumine on testicular and spermatological injuries experimentally stimulated by copper. We separated 36 male Sprague–Dawley rats into six equal groups: control, chrysin, flunixine meglumine, copper, copper +chrysin and copper +flunixine meglumine. Chrysin (50 mg/kg/bw/po), flunixine meglumine (2.2 mg/kg/bw/ip) and copper (500 mg/kg/bw/po) were administered day to day for 21 days. Copper administration caused significant morphological, physiological and biochemical alterations compared to the control group, which are as follows: production of oxidative stress, thanks to rise in testis lipid peroxidation and fall in antioxidant enzyme concentrations, decrease in sperm quality and increase in morphologic sperm abnormalities, suppression of spermatogenesis and prominent alterations in the testis histomorphology and induction of apoptosis in the testis tissues. On the other hand, compared to the copper group, treatment with chrysin or flunixine meglumine significantly attenuated these alterations. In conclusion, chrysin and flunixine meglumine have benefits such as antioxidant, antiapoptotic and anti-inflammatory against copper-induced testicular and spermatological damages in rats via the modulation of oxidative stress and apoptosis. Consequently, chrysin is a natural product which has comparable therapeutic actions to flunixine meglumine on the male reproductive system.
AtıfScopus4OpenAlex4İncele - MakaleAçık Erişim2022Scopus SJRQ2Effects of silver/selenium/chitosan doped hydroxyapatite coatings on REX-734 alloy: Morphology, antibacterial activity, and cell viability
Aksakal, B.; Say, Y.; Sinirlioglu, Z.A.
The goal of this study was to improve the antibacterial activity and cell viability of the Rex-734 alloy in biomedical applications. Various biocomposite coatings, such as single-layer hydroxyapatite (HAp), HAp/silver(Ag), and HAp/selenium(Se)/chitosan(Chit), were applied to Rex-734 alloy at various film thicknesses. The surface coatings were characterized by scanning electron microscopy, SEM, EDX, XRD and coating thickness and hardness of surface coatings were measured. The in vitro antibacterial activities of the coated and uncoated substrates were tested against Esherichia coli JM 103 and Staphylococcus aureus ATCC29293. In vitro cell–material interactions using Saos-2 osteoblast cells were characterized by the 3-(4,5-dimethylthiazol2-yl)− 2,5-diphenyltetrazolium bromide (MTT) assay for cell viability. The post-coating sintering parameters were shown to have a significant effect on the surface morphology. When compared to single HAp and HAp/Ag coatings, Se and Chit additions to HAp powders revealed good crack-free coating surfaces. Crack-free coating morphologies were achieved with a sintering speed of 3 °C/min. While single-HA coatings had an antimicrobial efficiency of 83% against E. coli, this value increased to 94% with Ag additive and to 85% with Se additive. Similarly, Ag and Se additives improved HAp's antimicrobial efficiency against Staphylococcus aureus. Cell viability decreased in the HAp/Ag coating at 86.5% and 90.93%, but increased significantly (p < 0.05) in the HA/Se-Chit coating at 137,43% and 158.23% at the end of the first and seventh days of incubation, respectively. The addition of Ag/Se/Chit to HAp increased the viability of the Rex-734 cells. Furthermore, it was revealed that the HAp-doped Se/Chit duplex biocomposite coating groups increased bone cell viability at much higher rates than the single-layer HAp coatings.
AtıfScopus12WoS8OpenAlex8İncele - MakaleAçık Erişim2022Scopus SJRQ1A multicriteria approach to integrating occupational safety & health performance and industry systems productivity in the context of aging workforce: A case study
Ortiz-Barrios, Miguel; Silvera-Natera, Esnela; Petrillo, Antonella; Gul, Muhammet; Yucesan, Melih
Aging represents one of the greatest challenges that mankind will have to face in the 21st century. In this regard, there is a need to deepen the technical and organizational aspects for rebalancing the job/employee relationship. Nevertheless, there are no robust approaches assisting decision-makers in the effective management of Occupational Safety & Health Performance (OSHP) and Industry Systems Productivity (ISP) convergence with a focus on Aging Workforce (AW). There is no single and unique solution. Therefore, in a win-to-win logic that favors the characteristic of the reference scenario, the aim of this paper is to propose a multicriteria approach to integrate OSHP and ISP in the context of AW. More specifically, Intuitionistic Fuzzy Analytic Hieararchy Process (IF-AHP) was used to elicit the criteria and sub-criteria under uncertainty considering degree of belongingness and non-belongingness. Decision Making Trial and Evaluation Laboratory (DEMATEL) was applied to evaluate the presence and strength of the interrelations and feedback among OSHP and ISP criteria and sub-criteria. Finally, Combined Compromise Solution (CoCoSo) was implemented to calculate a Working Suitability Index (WSI) per aging. Based on this index, interventions on each worker are proposed to underpin redesign of the company while to provide a flexible management propelling high performance in terms of OSHP and ISP. A real case study in Colombia is presented. The results revealed that Efficiency and Quality with 0.162 were found to be the most important factors in evaluating the performance of aging electrical engineers while Psychosocial risk and Occupational Safety were concluded to be the main drivers for a joint OSHP-ISP aging workforce management. The model can be an useful tool for policy and business decision-makers from the electrical sector and can be replicated with slight changes in other industries.
AtıfScopus17WoS11OpenAlex23İncele - MakaleAçık Erişim2022Scopus SJRQ3Electrochemical Detection of Ivermectin Used for the Treatment of COVID-19 with Glutardialdehyde-Modified Glassy Carbon Electrode
Koçak, Berna; İpek, Yeliz
In this study, the surface of the glassy carbon electrode was modified with glutardialdehyde. The modified glassy carbon electrode showed electrocatalytic activity against ivermectin. The glassy carbon electrode modified with glutardialdehyde showed high sensitivity, selectivity, and stability in the determination of ivermectin. The peak current of glutardialdehyde oxidation obtained by differential pulse voltammetry decreased inversely with the ivermectin concentration. Ivermectin inhibited the oxidation reaction of glutardialdehyde and caused a decrease in current. This change made the analysis of ivermectin electrochemically possible. In order to demonstrate the applicability of the developed method in real samples, recovery studies were carried out in tap water and urine. The highest sensitivity (0.45 µA/((µmol·L−1)(cm2))) was achieved with urine sample and the lowest detection limit as 2.66 × 10−6 mol·L−1 was obtained with BRT solution sample. Graphical abstract: [Figure not available: see fulltext.]
AtıfScopus14WoS13OpenAlex13İncele - MakaleYalnız künye2022Scopus SJRQ2Comparative Content, Biological and Anticancer Activities of Heracleum humile Extracts Obtained by Ultrasound-Assisted Extraction Method
Ocal, Mustafa; Altunoglu, Yasemin Celik; Angeloni, Simone; Mustafa, Ahmed M.; Caprioli, Giovanni; Zengin, Gokhan; Paksoy, Mehmet Yavuz; Baloglu, Mehmet Cengiz
As the safety and effectiveness of synthetic drugs remain in doubt, researchers are trying to develop natural medicines from medicinal plants. Herein, ethyl acetate, methanol and water extracts from the Heracleum humile plant were obtained by an ultrasonic-assisted extraction process and the aim was to evaluate some biological effects of the extracts due to the limited data on the pharmacological properties of Heracleum humile in the literature. Weak antibacterial activity was observed on tested bacterial species. The minimum inhibitory concentration and the minimum bactericidal concentration values ranged from 250 to 500 μg/mL. In addition, cytotoxic activity was determined using the MTT test. The strongest findings were determined for ethyl acetate extract on the MDA-MB-231 cell lines at the 48th hour (IC50:97.94 μg/mL), followed by the MCF-7 cell lines at the 24th hour (IC50:103.9 μg/mL). All extracts of Heracleum humile contained mainly flavonoids, phenolic acids and their derivatives, i. e., well-known compounds that possess numerous biological activities such as antioxidant, anti-inflammatory, anticancer, antimicrobial etc. The study results could provide important information that Heracleum humile could be a potential candidate as a natural enzyme inhibitor. It can be concluded that these extracts could be useful in the elementary step of improving novel plant-derived multifunctional pharmaceuticals.
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