Sürdürülebilir Kalkınma Amaçları

• 23
• 8
• 5
• 4
• 1

Yazarlar

• Serdar, Osman(15)
• Benzer, Fulya(10)
• Pala, Ayşegül(6)
• Erişir, Mine(5)
• Ates, Mehmet(4)
• Aydın, Ayşe Nur(4)
• Kocabaş, Mehmet(4)
• Mişe Yonar, Serpil(4)
• Orhan, Cemal(4)
• Seker, Engin(4)
• Yonar, Muhammet Enis(4)
• Yonar, Serpil Mise(4)
• Aksu, Önder(3)
• Arslan, Zikri(3)
• Aydin, Ayşe Nur(3)
• Erisir, Mine(3)
• Erten, Fusun(3)
• Kandemir, Fatih Mehmet(3)
• Kocabaş, Filiz Kutluyer(3)
• Sahin, Kazim(3)
• Yildirim, Nuran Cikcikoglu(3)
• Yonar, M. Enis(3)
• Ak, Kübra(2)
• Ak, Tuba Parlak(2)
• Baykara, Murat(2)
• Danabas, Durali(2)
• Demir, Veysel(2)
• Derman, Taner(2)
• Er, Akif(2)
• Er, Besir(2)
• Guler, Osman(2)
• Hanedan, Basak(2)
• Ispir, Unal(2)
• Juturu, Vijaya(2)
• Kandemir, F. M.(2)
• Kilic, Kubra(2)
• Kirbas, Akin(2)
• Kutluyer, Filiz(2)
• Minaz, Mert(2)
• Ozcelik, Mehtap(2)

• MakaleYalnız künye2011Scopus SJRQ2/r/munzur/4209
  Compensatory effects of curcumin on cisplatin-induced toxicity in rabbit testis

  Kandemir, F. M.; Benzer, F.; Yildirim, N. C.; Ozdemir, N.

  Curcumin, a widely used spice and colouring agent in food, has been shown to possess potent antioxidant, antitumor promoting and anti-inflammatory properties in vitro and in vivo. The present study was designed to investigate the protective effects of curcumin on changes in the levels of lipid peroxidation and endogenous antioxidants induced by cisplatin (cis-diamminedichloroplatinum II, CDDP) in the testiclular tissue of rabbits. 18 healthy male New Zealand white rabbits were equally divided into three groups of six rabbits each, control, cisplatin, and cisplatin+curcumin. The degree of protection produced by cisplatin was evaluated by determining the level of malondialdehyde (MDA) and glutathione (GSH), the activity of catalase (CAT), glutathione peroxidase (GSH-Px), were estimated from testes homogenates. MDA levels were increased with cisplatin compared to control but in cisplatin+curcumin group, MDA levels were found to be lower than cisplatin group (p<0.05). The activity of CAT and GSH-P-X was decreased in cisplatin and cisplatin+curcumin groups compared to control (p<0.05). In the case of cisplatin+curcumin CAT and GSH-Px activity were increased compared to cisplatin group (p<0.05). GSH levels were decreased with cisplatin but administration cisplatin+curcumin increased the levels of GSH comared to cisplatin group (p<0.05). In the present study, co-administration of curcumin with cisplatin prevented the damage to testes induced by this drug and may be considered as a potentially useful candidate in the combination chemotherapy with cisplatin.

  AtıfWoS22

  İncele
• MakaleAçık Erişim2010Scopus SJRQ3/r/munzur/4644
  Effects of cypermethrin on antioxidant status, oxidative stress biomarkers, behavior, and mortality in the freshwater mussel Unio elongatulus eucirrus

  Köprücü, Kenan; Yonar, Serpil Mise; Seker, Engin

  In this study, the effects of cypermethrin on antioxidant status, oxidative stress biomarkers, behavior, and mortality in the freshwater mussel Unto elongatulus eucirrus were examined. Cypermethrin was applied at concentrations of 5, 10, 20, 40, 80, and 160 mu g/L, for 1, 24, 48, 72, and 96 h. With increasing cypermethrin concentrations, the mussels showed significantly (P < 0.05) increased lipid peroxidation (MDA), which might be associated with decreased levels of reduced glutathione (GSH) and catalase (CAT) activity in the digestive glands and gills of the mussels. Negative correlations were observed between the MDA and the GSH and CAT levels after cypermethrin exposure, indicating a protective role of GSH and CAT against lipid peroxidation, and suggesting the use of these antioxidants as a potential biomarker of toxicity associated with contaminant exposure in freshwater mussels. In addition, at 5 mu g/L, cypermethrin had no effect on the duration of the active and rest periods. All higher concentrations caused inhibition of the filtration activity by reducing the active periods and lengthening the rest periods. The active periods shortened as the cypermethrin concentrations increased, the reduction being 90% of the control at 160 mu g/L. Rest periods were longest (237% longer than the control) at 160 mu g/L. The 48, 72, and 96 h LC50 values of cypermethrin for mussels were determined as 96.50, 77.96, and 59.20 mu g/L, respectively (P < 0.05). The results indicate that the insecticide cypermethrin has a harmful effect not only on nontarget aquatic arthropods and fish, but also on mollusks, although the sensitivity of mussels is less than that of fish. Being a general toxicant for aquatic life, cypermethrin should be used with great caution in agriculture to protect natural waters from contamination.

  AtıfWoS34

  İncele