Yazarlar
- Gul, Muhammet(35)
- Erten, Fusun(23)
- Zengin, Gokhan(23)
- Benzer, Fulya(22)
- Dal, Nursel Alp(20)
- Sahin, Kazim(20)
- Orhan, Cemal(19)
- Yeşiltepe, Akgün(17)
- Topal, Murat(15)
- Yucesan, Melih(15)
- Yildirim, Ozal(13)
- Öbek, Erdal(13)
- Aksakal, B.(12)
- Gürarslan Baş, Nazan(12)
- Alp Dal, Nursel(11)
- Baloglu, Ulas Baran(11)
- Cakilcioglu, Ugur(11)
- Kandemir, Fatih Mehmet(11)
- Paksoy, Mehmet Yavuz(11)
- Talo, Muhammed(11)
- Celik, Erkan(10)
- Er, Besir(10)
- Say, Yakup(10)
- Yaman, Mine(10)
- Yüksekol, Özlem Doğan(10)
- Aksu, Önder(9)
- Aslan, N.(9)
- Aslan, Naim(9)
- Baş, Kazım(9)
- Erişir, Mine(9)
- Mahomoodally, Mohamad Fawzi(9)
- Acharya, U. Rajendra(8)
- Caprioli, Giovanni(8)
- Karatay, Gülnaz(8)
- Kocabaş, Mehmet(8)
- Macit, Arife(8)
- Parlak Ak, Tuba(8)
- İpek, Yeliz(8)
- Beydağ, Kerime Derya(7)
- Camas, Mustafa(7)
Yayınlar
- MakaleAçık Erişim2021Scopus SJRQ4Presence of Neospora caninum DNA of Wild Birds from Turkey; [Türkiye’deki Vahşi Kuşlarda Neospora caninum DNA’sının Varlığı]
Karakavuk, Muhammet; Can, Hüseyin; Aldemir, Duygu; Döndüren, Ömer; Karakavuk, Tuğba; Karakavuk, Emrah; Özdemir, Hüseyin Gökhan; Muz, Mustafa Necati; Gürüz, Adnan Yüksel; Döşkaya, Mert
Objective: Neospora caninum is a protozoon parasite that has a worldwide distribution and mainly causes abortion in cattle and current serological evidence shows that the disease may be also zoonotic. Wild birds play a role as a reservoir of the disease in nature. The study aimed to determine the prensence of N. caninum in wild birds. Methods: In this study, the presence of neosporosis in wild birds (n=55) including 22 different species found in the western side of Turkey, was investigated by polymerase chain reaction (PCR). In addition, PCR positive samples were confirmed by sequencing, BLAST, and phylogenetic analysis using MEGA7. Results: Obtained results showed that the presence of N. caninum DNA was 5.45% (3/55) in brain-heart homogenates wild birds. The bird species which were found positive for N. caninum were little owl (Athene noctua), common buzzard (Buteo buteo), and little tern (Sternula albifrons). According to phylogenetic analysis and BLAST, all samples were compatible with reference N. caninum isolates. Conclusion: To the best of authors’ knowledge, this is the first study detecting N. caninum in little tern. In future studies, it may be interesting to investigate the prevalence of N. caninum in other wild animals to elucidate the transmission properties.
AtıfScopus3OpenAlex3
İncele - MakaleAçık Erişim2021Scopus SJRQ3Preliminary investigation on chemical composition and bioactivity of differently obtained extracts from Symphytum aintabicum Hub.- Mor. &Wickens
Zengin, Gokhan; Sinan, Kouadio Ibrahim; Ak, Gunes; Angeloni, Simone; Maggi, Filippo; Caprioli, Giovanni; Kaplan, Alevcan; Çakılcıoğlu, Uğur; Akan, Hasan; Jugreet, Sharmeen
Symphytum species, commonly known as comfrey, hold a long history of folk medicinal uses for healing wounds, bone fractures and other pain resulting from inflammation. However, many species belonging to this genus have not yet been scientifically investigated and hence investigation in this regard is warranted. In the present research, S. aintabicum extracts prepared by different extraction techniques (homogenizer assisted extraction, infusion and maceration) were assayed for their chemosystematic attributes (total phenolic, flavonoid) as well as bioactive compound contents, antioxidant and enzyme inhibition potentials. For instance, the extracts were found to possess phenolic and flavonoid levels ranging from 35.50 to 112.25 mg GAE/g and 2.54–25.12 mg RE/g, respectively. In general, the extracts displayed significant antioxidant activity. However, methanolic and infusion extracts were observed as the most potent radical scavengers and reducing agents, most likely related to their phenolic content. The extracts also showed metal chelating power and total antioxidant capacity in phosphomolybdenum assay. Moreover, while all extracts showed inhibition on amylase, only the methanolic extracts acted as inhibitors of cholinesterases and tyrosinase, most probably due to their relatively higher flavonoid content. The findings also indicated that the extraction method as well as the solvent type used to more or less affect the yield of the bioactive compounds and extracts’ bioactivity reported herein. Hence, as a first report highlighting the in vitro pharmacological properties of S. aintabicum, promising results were revealed from the quantitative chemosystematic analysis of bioactive components present and as sources of antioxidants and enzyme inhibitors against key human illnesses, thus providing scope for potential applications in phytomedicine development.
AtıfScopus15OpenAlex14
İncele - BildiriAçık Erişim2021Deep Neural Network Trained on Surface ECG Improves Diagnostic Accuracy of Prior Myocardial Infarction over Q Wave Analysis
Yildirim, Ozal; Baloglu, Ulas B; Talo, Muhammed; Ganesan, Prasanth; Tung, Jagteshwar S; Kang, Guson; Tooley, James; Alhusseini, Mahmood I.; Baykaner, Tina; Wang, Paul J.
Clinical screening of myocardial infarction is important for preventative treatment and risk stratification in cardiology practice, however current detection by electrocardiogram Q-wave analysis provides only modest accuracy for assessing prior cardiac events. We set out to evaluate the ability of a deep neural network trained on the electrocardiogram to identify patients with clinical history of myocardial infarction. We assessed 608 patients at two academic centers with adjudicated history of myocardial infarction. Surface electrocardiograms were used to train a neural network-based model that classifies patients with and without a history of infarction. Endpoints were assessed by clinical record review and accuracy of the model was compared against the manual assessment of pathologic Q waves. The neural network outperformed the accuracy of pathologic Q waves (62%). In training, the model accuracy converged to >98%. Validation was performed by cross-validation (k=5) with validation accuracy 71 ± 5%. Receiver-operator characteristics analysis resulted in a c-statistic of 0.730. Deep learning of a 12-lead ECG can identify features of prior myocardial injury more accurately than clinical Q-wave analysis and may serve as a valuable clinical screening tool.
AtıfScopus3OpenAlex3İncele - MakaleAçık Erişim2021Scopus SJRQ2Protective Effect of Lutein/Zeaxanthin Isomers in Traumatic Brain Injury in Mice
Gunal, Mehmet Yalcin; Sakul, Ayse Arzu; Caglayan, Ahmet Burak; Erten, Fusun; Kursun, Oznur Ece Durmaz; Kilic, Ertugrul; Sahin, Kazim
Previous studies revealed that oxidative stress and inflammation are the main contributors to secondary injury after traumatic brain injury (TBI). In an earlier study, we reported that lutein/zeaxanthin isomers (L/Zi) exert antioxidative and anti-inflammatory effects by activating the nuclear factor-kappa B (NF-κB) and nuclear factor-erythroid 2-related factor 2 (Nrf2) pathways. However, its precise role and underlying mechanisms were largely unknown after TBI. This study was conducted to investigate the potential mechanism of L/Zi isomers in a TBI model induced by a cold injury model in mice. To investigate the effects of L/Zi, male C57BL/6j mice-induced brain injury using the cold trauma model was allocated into two groups (n = 7): (i) TBI + vehicle group and (ii) TBI + L/Zi group (20 mg/kg BW). Brain samples were collected 24 h later for analyses. L/Zi given immediately after the injury decreased infarct volume and blood–brain barrier (BBB) permeability; L/Zi treatment also significantly reduced proinflammatory cytokines, including interleukin1 beta (IL-1β), interleukin 6 (IL-6), and NF-κB levels and increased growth-associated protein 43 (GAP-43), neural cell adhesion molecule (NCAM), brain-derived neurotrophic factor (BDNF), and Nrf2 levels compared with vehicle control. These data suggest that L/Zi improves mitochondrial function in TBI models, possibly decreasing inflammation and activating the Nrf2 pathway.
AtıfScopus39OpenAlex40İncele - MakaleYalnız künye2021Scopus SJRQ4Reflection of eating awareness and life engagement of university students on the coronavirus (COVID-19) pandemic
Önen, Cihan; Sandikçi, Muhammed Bahadır
Study Objectives: With the restrictions in the pandemic process and the distance education process, changes have occurred in the diet of students. In such periods, which affect human life in a significant way in terms of public health, nutrition must be managed well. The study was conducted to evaluate the eating awareness of university students during the COVID-19 pandemic period and to examine its relationship with their engagement in life. Methods: The population of the cross-sectional study consists of the students of Munzur University. As a precaution regarding the COVID-19 pandemic, the participants were reached on the internet. Results: Eating awareness was statistically higher in men, married people, those with normal weight, and older students. While the life engagement among university students was high, the mean scores of eating awareness and its sub-components were moderate. Life engagement was significantly higher in sports science students than students in other academic units. There was a weak but significant relationship between eating awareness and engagement in life. Conclusion: Eating awareness of university students during the pandemic is at a moderate level. Students with high eating awareness are attached to life more. The highest life engagement among academic units is among sports science students. There is a need for public health initiatives to increase the awareness of eating among the students, against COVID-19 and possible future pandemics.
AtıfScopus3WoS2OpenAlex3İncele - MakaleYalnız künye2021Scopus SJRQ2Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti-inflammatory, and antiapoptotic properties
Ileriturk, Mustafa; Benzer, Fulya; Aksu, Emrah Hicazi; Yildirim, Serkan; Kandemir, Fatih Mehmet; Dogan, Tuba; Dortbudak, Muhammet Bahaeddin; Genc, Aydin
In the present study, the protective effects of chrysin (CHR) against testicular damage caused by lead acetate (PbAc) were examined. In this way, 30 min after rats were given 25 and 50 mg/kg/b.w CHR orally for seven consecutive days, 30 mg/kg/b.w PbAc was administered orally. In biochemical analysis of testicular tissue, it was found that PbAc-reduced antioxidant parameters [glutathione peroxidase (GPx), glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT)], while it increased lipid peroxidation, inflammatory markers [nuclear factor kappa-B (NF-κB), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE-2), and inducible nitric oxide synthase (iNOS)], and 8-hydroxy-2′-deoxyguanosine (8-OHdG). In the immunohistochemical examination, it was determined that PbAc increased the expression of tumor necrosis factor-α (TNF-α) and caspase-3. Accordingly, PbAc was found to cause a decrease in sperm motility and an increase in the percentage of dead sperm. However, it has been observed that CHR relieves oxidative stress due to its antioxidant properties, thus protecting against inflammation and apoptosis. It also allowed the CHR sperm parameters to return to control group levels. The results revealed that CHR could be a natural substance to be used in Pb-induced testicular toxicity. Practical applications: Lead (Pb) is an important environmental contaminant heavy metal. Pb is believed to reduce fertility in men. Oxidative stress plays a significant role in the damage caused by Pb to testicular tissue. CHR is an antioxidant substance that occurs naturally in various plants and has various pharmacological properties. In the present study, it was investigated whether CHR has a protective effect against testicular toxicity induced by PbAc. The results revealed that in rats, CHR protects the testicular tissue from PbAc toxicity by showing antioxidant, anti-inflammatory and anti-apoptotic effects, thus bringing sperm parameters closer to normal.
AtıfScopus76WoS71OpenAlex81İncele - MakaleYalnız künye2021Scopus SJRQ2Developing Antibacterial Cotton Fabric with Zinc Borate Impregnation Process
İpek, Yeliz; Ertekin, Özlem
Cotton fabric is a commonly used textile because of its natural and healthy properties. The chemical structure of cotton consists cellulose with a ratio of over 90 %. Cellulose is a natural polymer and cotton fabric is a quiet useful textile because of its better moisture absorption, softness, and easy care properties. Moisture absorbtion property comes from the cellulosic structure of the fabric. However, its features such as being hydrophilic and inclinable to bacterial growth limits its application areas. Antibacterial cotton fabric may be used for hospital textiles such as hospital gowns, patient clothes, wound bandages; food packaging and storage textiles; home textiles like curtain, bed cover; clothing, etc. In this study, a novel environmentally friendly antibacterial cotton fabric was developed. Flame retardant zinc borate was used as antibacterial agent. For this purpose, zinc borate with a formula of ZnO·3B2O3·7H2O had been synthesized with wet chemical precipitation method and cotton fabric was treated with this material via sol-gel impregnation method. The impregnation method for cotton fabric provided a uniform distribution of zinc borate particles and processing the entire volume of the fiber. This method is also suitable for large quantity production processes. In the microbiological studies, Enterococcus which is commonly associated with the nosocomial infections and food spoilage was used. As a result, the antibacterial activity was observed in the fabrics treated with 0.1 mol·l−1 and 0.2 mol·l−1 concentration of zinc borate solutions.
AtıfScopus16WoS13OpenAlex14İncele - MakaleYalnız künye2021Scopus SJRQ1Protective Effects of Chrysin Against Oxidative Stress and Inflammation Induced by Lead Acetate in Rat Kidneys: a Biochemical and Histopathological Approach
Kucukler, Sefa; Benzer, Fulya; Yildirim, Serkan; Gur, Cihan; Kandemir, Fatih Mehmet; Bengu, Aydin Sukru; Ayna, Adnan; Caglayan, Cuneyt; Dortbudak, Muhammet Bahaeddin
In this study, the protective effects of chrysin (CR) on lead acetate (PbAc)-induced renal toxicity in Sprague-Dawley rats were investigated with biochemical, histopathological, and immunohistochemical methods. In the study, rats were given orally at 30 mg/kg/body weight (BW) PbAc after CR of 25 and 50 mg/kg/BW was administered to them orally (a total of 7 administrations for 7 days). The results showed that CR reduced urea and creatinine levels by alleviating PbAc-induced kidney damage. It was determined that CR decreases PbAc-induced lipid peroxidation due to its antioxidant properties and increases catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) activities, and glutathione (GSH) levels. It was also detected that CR protects DNA from the toxic effects of PbAc and reduces 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels. Biochemical and immunohistochemical findings demonstrated that CR had anti-inflammatory and antiapoptotic effects and reduced nuclear factor kappa-B (NF-κB), interleukin-33 (IL-33), prostaglandin-E2 (PGE-2), tumor necrosis factor-α (TNF-α), p53 levels, and the activities of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), which were increased with PbAc administration. Moreover, CR was found to increase the levels of aquaporin-1 (AQP-1) and nephrine in PbAc-induced kidney tissue. CR decreased the contents of lead (Pb), zinc (Zn), iron (Fe), sodium (Na), and copper (Cu) and increased those of potassium (K) calcium (Ca) in renal tissue. These results indicated that CR considerably alleviates kidney toxicity caused by PbAc.
AtıfScopus136WoS118OpenAlex145İncele - MakaleAçık Erişim2021Scopus SJRQ2Exposure to copper and risk assessment for human health via consumption of alcoholic beverages
Ince, Muharrem; Kaplan Ince, Olcay; Onal, Ali
Present study was performed using a Box–Behnken Design (BBD) combined with a response surface methodology (RSM). The ultimate goal of this research was to apply BBD for modeling of copper (Cu2+) ions from alcoholic beverages and evaluate health risk assessment of Cu2+ via consumption of alcoholic beverages. The importance of independent paramaters and their interactions were examined using analysis of variance (ANOVA). Natural clay was investigated to remove Cu2+ ions from some alcoholic beverage samples including beer and wine. X-ray diffraction (XRD), fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) coupled with energy dispersive X-ray (EDS) analysis were used for adsorbent characterization. Same analyzes were applied for Cu2+ loaded clay. In addition, experimental studies showed that Freundlich isotherm was better than Langmuir isotherm. Finally, optimized method was applied to alcoholic beverages. Besides target hazard quotients (THQ), estimated daily intake (EDI) values were calculated, to assess a health risk resulting from these alcoholic beverages regular consumption. The EDI values of Cu (µg/day/person) through consumption of investigated drinks were less than the recommended dietary allowance values. Also, the THQ values of Cu2+ were less than 1. According to estimated target hazard, it can be said no long life health concerns of Cu2+ is associated with the consumption of studied drinks. Obtained results were compared with the data from literature and levels set by regulatory authorities, it can be clearly stated that the consumption of mentioned alcoholic beverages do not pose a toxicological risk.
AtıfScopus14WoS10OpenAlex11İncele - MakaleAçık Erişim2021Scopus SJRQ1Evaluation of non-carcinogenic health risks of thallium in grapevine exposed to mine waters of an abandoned mining region in Turkey
Topal, Murat; Arslan Topal, E. Işıl; Öbek, Erdal
In this study, non-carcinogenic health risks of thallium in grapevine exposed to mine waters of an abandoned mining region in Turkey were evaluated. The values of thallium were investigated in leaves, stems, and roots. Translocation factors (TF) and bioaccumulation concentration factors (BCF) were determined. The maximum thallium value in grapevines (root) was 2.34 ± 0.12 mg/kg. Thallium values in grapevine were stem < leaf < root. The bioconcentration value calculated in our study is higher than 1 showing thallium bioaccumulation from the mine water to grapevines. Translocation factor value is calculated as 1.20. The high total estimated daily exposure dose (TED) in grapevines was determined as 1.10E-02 mg/kg day for children. TEDs values in grapevines were observed as male < female < children, respectively. The maximum HQ risk value for male was observed as 1060 for children. The non-carcinogenic risk values were children > female > male. Hazard index values of thallium in grapevines were ingestion < dietary. As a result, hazard and total hazard index values were > 1 for thallium in grapevines. Therefore, there are non-carcinogenic health risks of thallium in grapevine exposed to mine waters of an abandoned mining region.
AtıfScopus3WoS1OpenAlex2İncele - MakaleYalnız künye2021Scopus SJRQ2Two Medicinal Plants (Alkanna trichophila and Convolvulus galaticus) from Turkey: Chemical Characterization and Biological Perspectives
Mahomoodally, Mohamad Fawzi; Zengin, Gokhan; Sinan, Kouadio Ibrahime; Ak, Gunes; Sadeer, Nabeelah Bibi; Angeloni, Simone; Mustafa, Ahmed M.; Caprioli, Giovanni; Maggi, Filippo; Cakilcioglu, Ugur
The aim of the present study was to quantify selected phenolic compounds, determine antioxidant activity and enzyme inhibitory effects of the aerial parts of Alkanna trichophylla Hub.-Mor. (A. trichophylla) and Convolvulus galaticus Rost.ex Choisy (C. galaticus) extracts prepared by homogenizer-assisted extraction (HAE), maceration (MAC) and infusion techniques. This is the first time such study has been designed to validate the phytochemical composition and bioactivity of these plants. Multivariate analysis was conducted on collected data. Rutin and caffeoylquinic acid derivatives were the most significant compounds in A. trichophylla and C. galaticus, respectively. The highest antioxidant activity of A. trichophylla was mostly exhibited by HAE/methanolic extracts as determined by DPPH, ABTS, FRAP (51.39, 112.70 and 145.73 mg TE/g, respectively) and phosphomolybdenum (2.05 mmol TE/g) assays. However, significant antioxidant activities varied within the extracts of C. galaticus. HAE/methanolic extract of A. trichophylla significantly depressed AChE (2.70 mg GALAE/g), BChE (5.53 mg GALAE/g) and tyrosinase (26.34 mg KAE/g) activities and that of C. galaticus inhibited AChE (2.04 mg GALAE/g), tyrosinase (31.25 mg KAE/g) and α-amylase (0.53 mmol ACAE/g) activities significantly. We concluded that HAE was the most efficient extraction technique as high yield of compounds and promising bioactivities were recorded from extracts prepared. Multivariate analysis showed that types of solvents influenced recovery of compounds and biological activities. This research study can be used as one methodological starting point for further investigation on these plants as all results are clearly promising and open the door to further research challenges such as cytotoxicity evaluation, molecular docking analysis, and more screening of pharmacological actions.
AtıfScopus12OpenAlex10İncele - MakaleAçık Erişim2021Scopus SJRQ4Electrochemical Corrosion and Metal Ion Release Protective Efficiency of the Multilayer TaN Coatings on CoCrMo Biomedical Alloy
Aslan, Ali Kemal; Bahçe, Erkan; Güler, Mehmet Sami
CoCrMo alloy is widely used in artificial orthopedic joint applications due to its high mechanical properties. But, high levels of the metal ion release from alloy surfaces cause variable toxic and allergic effects on the patient in vivo use. This case restricts the lifetime of the implant and results in the failure of the artificial joint. In order to enhance the corrosion resistance and to decrease the metal ion release, alloy surface was multilayer-coated by closed field unbalanced magnetron system. The protective efficiency of the coatings was determined by potentiodynamic polarization tests and static immersion tests were performed for 45, 60 and 90 days in the simulated body fluid in order to understand the effect of the coatings on the metal ion release. The metal ion concentrations in the simulated body fluids were determined by using inductively coupled plasma mass spectrometry device. The electrochemical corrosion results showed that the multilayer coatings provided 93 % protective efficiency in terms of corrosion resistance. Multilayer coatings decreased the metal ions release levels significantly, especially Co leaking was decreased approximately 52 times compared to uncoated samples.
AtıfScopus2WoS3OpenAlex1İncele - MakaleAçık Erişim2021Scopus SJRQ2Comparative Toxicity of Alpha and Gamma Iron Oxide Nanoparticles in Rainbow Trout: Histopathology, Hematology, Accumulation, and Oxidative Stress
Gürkan, Mert; Gürkan, Selin Ertürk; Yılmaz, Sevdan; Ateş, Mehmet
In this study, alpha and gamma iron oxide nanoparticles, characterizations, toxic effects after being exposed to rainbow trout (Oncorhynchus mykiss) at 0, 1, 10 and 25 mg/L concentrations for 10 days, and then 10-day recovery period without any nanoparticle exposure were examined for histopathological (kidney, liver and gill), hematological, iron accumulation and potential for oxidative stress (TBARS and GSH). Histopathological damages significant at the exposure of increasing concentrations of both nanoparticles (increase in melanomacrophage aggregations, epithelial tissue deformations, cytoplasmic vacuolizations, fatty changes, necrosis, pyknosis, hyperplasia, hypertrophy, lamellar fusions, capillary dilatations). Gamma nanoparticles were determined to accumulate more than the alpha nanoparticles. The most Fe accumulation was detected in the liver. The findings of oxidative stress parameters showed that both nanoparticles have the potential to generate oxidative stress. It was concluded that the exposure of alpha and gamma nanoparticles at specified concentrations and durations had a toxic effect on rainbow trout and the toxicity of these nanoparticles was similar.
AtıfScopus18WoS12OpenAlex16İncele - MakaleAçık Erişim2021Scopus SJRQ2Hospital Preparedness Assessment against COVID-19 Pandemic: A Case Study in Turkish Tertiary Healthcare Services
Gul, Muhammet; Yucesan, Melih
Hospitals play a critical role in providing essential health services to people in the healthcare system. Healthcare systems around the world have faced some issues in responding to patients with various disease severity levels. Nowadays, the world as a whole is combating a pandemic called COVID-19. This pandemic causes an increase in the disease spread with fluctuated patient demand that may affect the hospitals' capacity and overall functioning and risks rising based on hospital site, medical staff, patient, and healthcare process. To deal with the challenges of the COVID-19 pandemic, hospitals must have completed their preparations before these events occur. Therefore, this study proposes an integrated approach based on the decision-making concept with interval-valued spherical fuzzy sets (IVSFSs) to the hospital preparedness assessment problem. A technique for order preference by similarity to ideal solution (TOPSIS) extended with IVSFSs is used to rank hospitals from Turkish tertiary healthcare services. A checklist reported by the World Health Organization (WHO) is adapted to conform to Turkey's COVID-19 pandemic management. Ninety-nine subcomponents of the adapted checklist under ten components are weighted by interval-valued spherical weighted arithmetic mean (IVSWAM) operator. The hospitals in the problem are then ranked concerning these weighted subcomponents. With the proposed approach, a COVID-19 pandemic preparedness index is determined for the observed hospitals. In addition, a separate index based on each main component (component-based ranking) is determined. These indexes are vital indicators in determining in which aspects hospitals are ready and in what aspects hospitals are not prepared for pandemics. The proposed approach can be adaptable and applied by national policymakers in assessing all hospitals of the country against the COVID-19 pandemic.
AtıfScopus45WoS33OpenAlex44İncele - MakaleYalnız künye2021Scopus SJRQ3Determination of the estimated amounts of discarded face masks due to COVID 19 in Turkey
Topal, Murat; Topal, Emine Işıl Arslan
In this study, the estimated amounts of discarded face masks due to COVID 19 were investigated. In this context, the amount of waste face masks was determined separately according to the mask types used (nonwoven, meltblown, and 3-ply, pleated) and the importance of waste face masks was revealed. According to obtained data, the estimated total daily face mask use in Turkey is 72,351,638. The highest amounts of nonwoven, meltblown, and 3-ply face mask waste were determined as 26.88, 36.29, and 43.68 tonnes/day for İstanbul city, respectively. Total amounts of nonwoven, meltblown and 3-ply face mask waste in Turkey were calculated as 144.7, 195.35, and 235.14 tonnes/day, respectively. The top 5 provinces with the highest amount of waste masks are listed as follows; İstanbul (nonwoven=26.88, meltblown=36.29, 3ply=43.68 tonnes/day), Ankara (nonwoven=9.91, meltblown=13.38, 3ply=16.11 tonnes/day), İzmir (nonwoven=7.76, meltblown=10.47, 3ply=12.61 tonnes/day), Bursa (nonwoven=5.40, meltblown=7.29, 3ply=8.78 tonnes/day), and Antalya (nonwoven=4.45, meltblown=6.01, 3ply=7.23 tonnes/day), respectively. In Turkey, 91.3% of medical waste collected in health institutions in 2019 (90,920 tonnes) was sterilized and disposed of in storage areas (83,010 tonnes). 8.7% of medical waste was sent to incineration facilities and disposed (7,910 tonnes). Considering these values, 132, 178.35, and 214.7 tonnes/day of nonwoven, meltblown, and 3-ply face mask wastes can be disposed by sterilization and the remaining 12.7, 17, and 20.44 tonnes/day by incineration, respectively.
AtıfScopus5OpenAlex4İncele - MakaleAçık Erişim2021Scopus SJRQ2Lycopene ameliorates propionic acid-induced autism spectrum disorders by inhibiting inflammation and oxidative stress in rats
Erten, Fusun
This study was conducted to study lycopene efficacy in brain-behavior, pro-inflammatory and apoptotic markers, and antioxidant levels in a rodent model. Rats were administered with propionic acid (PPA) (500 mg/kg BW) to induce autism-like disorders, then treated with different lycopene (L) concentrations (5, 10, 20 mg kg−1 day−1) for 35 days. The groups were: (i);control, (ii);PPA, (iii);PPA + L5, (iv);PPA + L10, and (v);PPA + L20. In this study, serum and brain malondialdehyde (MDA) levels decreased with lycopene supplements compared to the PPA group, similarly to the brain levels of inflammatory factors (IL-1α, IL-8, NF-κB, TNF-α; p <.05). Besides, brain levels of anti-apoptotic Bcl-2 decreased, whereas pro-apoptotic Bax, antioxidant Nrf2, and HO-1 levels in brain increased compared with PPA (p <.05). This study showed that lycopene might have therapeutic value to improve the dysfunctions in learning and memory in a dose-dependent way, along with the antioxidant, anti-inflammatory, and antiapoptotic molecular responses in a rat model of ASD-like disorders. Practical applications: This study suggested that lycopene can reduce propionic acid (PPA)-induced learning and memory impairment and oxidative damage by participating in multiple biological activities such as antioxidant, and anti-inflammatory effects. Lycopene protects serum and brain tissues against PPA induced oxidative damage in rats. These effects may be realized through up-regulation of the brain Nrf2/HO-1 pathway and down-regulation of the IL-1α, IL-8, TNF-α, and NF-κB levels. Lycopene may also contribute to memory and learning function, apoptotic/antiapoptotic modulation, and antioxidant and possible therapeutic efficacy in PPA-induced- Autism spectrum disorder cases.
AtıfScopus26WoS19OpenAlex26İncele - MakaleAçık Erişim2021Scopus SJRQ2In vitro biological activity of Salvia fruticosa Mill. infusion against amyloid β-peptide-induced toxicity and inhibition of GSK-3β, CK-1δ, and BACE-1 enzymes relevant to Alzheimer's disease
Gürbüz, Perihan; Dokumacı, Alim Hüseyin; Gündüz, Miyase Gözde; Perez, Concepcion; Göger, Fatih; Paksoy, Mehmet Yavuz; Yerer, Mükerrem Betül; Ömür Demirezer, L.
Salvia species have been traditionally used to improve cognition and have been proved to be a potential natural treatment for Alzheimer's disease. Salvia fruticosa Mill. (Turkish sage or Greek sage) demonstrated to have anticholinergic effects in vitro. The aim of this study was to understand the mechanism underlying the neuroprotective effects of S. fruticosa infusion and its representative compound rosmarinic acid, which was detected by LC-DAD-ESI-MS/MS. The protective effects of the S. fruticosa infusion (SFINF) and its major substance rosmarinic acid (RA) on amyloid beta 1–42 -induced cytotoxicity on SH-SY5Y cells together with p-GSK-3β activation were investigated. Their in vitro inhibitory effects against glycogen synthase kinase 3β, β-secretase, and casein kinase 1δ enzymes were also evaluated. The results showed that treatment with the all tested concentrations, SFINF significantly decreased Aβ 1–42-induced cytotoxicity and exhibited promising in vitro glycogen synthase kinase 3β inhibitory activity below 10 µg/mL (IC50 6.52 ± 1.14 µg/mL), in addition to β-secretase inhibition (IC50 86 ± 2.9 µg/mL) and casein kinase 1δ inhibition (IC50 121.57 ± 4.00). The SFINF (100 µg/mL and 250 µg/mL) also activated the expression of p-GSK-3β in amyloid beta 1–42 treated SH-SY5Y cells. The outcomes of this study demonstrated that the S. fruticosa infusion possessed activity to prevent amyloid beta 1–42 -induced neurotoxicity and provided proof that its mechanism may involve regulation of p-GSK-3β protein.
AtıfScopus18OpenAlex17İncele - MakaleAçık Erişim2021Scopus SJRQ1Ameliorative effect of Fennel (Foeniculum vulgare) essential oil on chlorpyrifos toxicity in Cyprinus carpio
Pala, Ayşegül; Serdar, Osman; Mişe Yonar, Serpil; Yonar, Muhammet Enis
Chlorpyrifos (CPF) is an organophosphate pesticide that is frequently and widely used to control both agricultural and domestic pests worldwide. In this study, the protective effect of Fennel (Foeniculum vulgare) essential oil (FEO) was investigated in carp (Cyprinus carpio) exposed to CPF. The fish were divided into six groups that one control group (no treatment) and five experimental groups (FEO (3ml/100g diet) group, CPF1 (0.023 mg/l) group CPF2 (0.046 mg/l) group, CPF1 (0.023 mg/l) plus FEO (3ml/100g diet) group, CPF2 (0.046 mg/l) plus FEO (3ml/100g diet) group). Blood and tissue (liver, kidney, gill, and brain) samples were taken from the fish at the end of 14 days of application. Hemoglobin (Hb) level, nitoblue tetrazolium (NBT) activity, and total immunoglobulin (TI) level were measured in blood samples of fish. Acetylcholinesterase (AChE) activity was determined in brain tissue while malondialdehyde (MDA) level, reduced glutathione (GSH) level, catalase (CAT), and glutathione peroxidase (GPx) activity were determined in liver, kidney, and gill tissues. The results showed that there was a significant decrease in Hb level, NBT activity, and TI levels in CPF-treated fish compared to the control group. In addition, increased in MDA levels and significant decreases in GSH level, AChE, CAT, and GPx activities were observed in CPF-treated groups. However, FEO-treated was showed a significant improvement in all parameters except AChE activity compared to CPF groups. These study findings showed that FEO could improve CPF-induced toxicity in C. carpio, except inhibition of AChE activity.
AtıfScopus6WoS6OpenAlex8İncele - MakaleYalnız künye2021Scopus SJRQ2The Effect of the Transtheoretical Model Based Walking Exercise Training and Follow-Up on Improving Exercise Behavior and Metabolic Control in Patients with Type 2 Diabetes
Kaplan Serin, Emine; Citlik Saritas, Seyhan
This study aims to determine the effects of transtheoretical model-based walking exercise training and follow-up on improving exercise behavior and metabolic control in patients with type 2 diabetes. This randomized controlled trial was conducted as a pre-test and post-test experimental model with 76 intervention and 76 control individuals. The intervention group received the transtheoretical model-based exercise training. Data were collected using patient identification form, transtheoretical model scales, pedometer and metabolic outcomes. Data were analyzed by Chi square, two-way ANOVA, Mauchly’s, Greenhouse-Geisser, Friedman, and McNamer test. The overall score means for the exercise change processes, decision-making balance and self-efficacy scales increased compared to the pre-test (p <.001). The mean HDL increased from 41.39 ± 10.35 to 49.18 ± 11.58, and average number of steps per day increased from 3264.31 ± 1933.03 to 5639.37 ± 2317.01. Consequently, this difference between the groups was significant (p <.05).
AtıfScopus11WoS8OpenAlex9İncele - MakaleYalnız künye2021Multivariate statistical evaluation of dissolved trace elements and water quality assessment in the Karaca dam, Turkey
Kutlu, Banu; Mutlu, Ekrem
This study was performed from January 2017 to December 2017 with taking samples every month from four stations to determine the water quality of Ka-raca Dam, located in Sinop. The guidelines of the World Health Organization for water quality index (WQI) and Turkey’s Ministry of Forestry and Water Affairs specifications for Surface Water Quality Regulations (SWQR) were used in the determination of water quality and 28 variables were analyzed. The quality of the irrigation water was also calculated. This objective, the sodium adsorption ratio (SAR), sodium percentage, permeability index (PI), and mag-nesium index were calculated. The average WQI value of the lake was found to be 19.23. It was observed that the water quality parameters did not exceed the restrictions in any stations during the period. According to the results of the research, Karaca Dam is in a good class in terms of drinking water quality and irrigation water. The health risk evaluation, using the hazard ratio and index (HI), was carried out as suggested by USEPA, and it was found that the water of Karaca Dam is not harmful to human health in terms of Pb, Cd, and Hg.
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